id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353731-7xn7m662	Heaton, Brook E.	SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2	2020-08-18		.txt	text/plain	2233	139	51	sgRNA sequencing data indicated that the host gene with the highest probability of being 125 required for SARS-CoV-2 infection was the serine/arginine-rich protein kinase, SRPK1 126 ( Figure 1B) . We next wanted to define the degree to which inhibition of SRPK1 mediated N 141 phosphorylation would affect viral replication, especially since other non-SRPK1 kinases 142 have been predicted to be responsible for SARS-CoV-2 protein phosphorylation 12,13 . SRPIN340 treatment of cells infected with the 183 alphacoronavirus 229E (which is only distantly related to betacoronavirus SARS-CoV-2) 184 inhibited the virus by more than 1,000-fold at non-toxic concentrations of the drug ( Figure 185 2G-H). Human papillomavirus type 1 E1^E4 protein is a potent 533 inhibitor of the serine-arginine (SR) protein kinase SRPK1 and inhibits 534 phosphorylation of host SR proteins and of the viral transcription and replication 535 regulator E2	./cache/cord-353731-7xn7m662.txt	./txt/cord-353731-7xn7m662.txt