id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353742-k4gxww2c	Arévalo, AP	Ivermectin reduces coronavirus infection in vivo: a mouse experimental model	2020-11-02		.txt	text/plain	721	66	48	SARS-CoV2 is a single strand RNA virus member of the type 2 coronavirus family, responsible for causing COVID-19 disease in humans. The objective of this study was to test the ivermectin drug in a murine model of coronavirus infection using a type 2 family RNA coronavirus similar to SARS-CoV2, the mouse hepatitis virus (MHV). Overall results demonstrated that viral infection induces the typical MHV disease in infected animals, with livers showing severe hepatocellular necrosis surrounded by a severe lymphoplasmacytic inflammatory infiltration associated with a high hepatic viral load (52,158 AU), while ivermectin administration showed a better health status with lower viral load (23,192 AU; p<0.05) and few livers with histopathological damage (p<0.05), not showing statistical differences with control mice (P=NS). In conclusion, ivermectin seems to be effective to diminish MHV viral load and disease in mice, being a useful model for further understanding new therapies against coronavirus diseases.	./cache/cord-353742-k4gxww2c.txt	./txt/cord-353742-k4gxww2c.txt