id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355758-tk7eturq	Berrio, Alejandro	Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function	2020-09-22		.txt	text/plain	2175	156	49	Background The emergence of a novel coronavirus (SARS-CoV-2) associated with severe acute respiratory disease (COVID-19) has prompted efforts to understand the genetic basis for its unique characteristics and its jump from non-primate hosts to humans. Tests for positive selection can identify apparently nonrandom patterns of mutation accumulation within genomes, highlighting regions where molecular function may have changed during the origin of a species. Several recent studies of the SARS-CoV-2 genome have identified signals of conservation and positive selection within the gene encoding Spike protein based on the ratio of synonymous to nonsynonymous substitution. In addition, we find other likely targets of positive selection within the genome of SARS-CoV-2, specifically within the genes encoding Nsp4 and Nsp16. In Importantly, we also detected signals of positive selection in two additional regions of the 414 SARS-CoV-2 genome, specifically within the genes encoding Nsp4 and Nsp16 (Fig 1A) . Comparative analysis of coronavirus genomic RNA structure reveals 718 conservation in SARS-like coronaviruses.	./cache/cord-355758-tk7eturq.txt	./txt/cord-355758-tk7eturq.txt