id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355811-aq7p1uxo	Węglarz-Tomczak, Ewelina	Discovery of potent inhibitors of PLproCoV2 by screening a library of selenium-containing compounds	2020-05-21		.txt	text/plain	2008	151	57	A collection of twelve organoselenium compounds, structural analogues of antioxidant drug ebselen were screened for inhibition of the papain-like protease (PLpro) from the acute respiratory syndrome coronavirus 2 (SARS-CoV-2, CoV2). In recent studies, peptide analogues [11] and ebselen [12] have been identified as highly active inhibitors for PL pro . We show that some of them indeed possess higher activity than ebselen, that has been recently reported as PL pro CoV2 inhibitor [12] , and, thus, could be considered as novel potential drugs against COVID-19. In this work, we used the ebselen derivatives/analogues library and performed a comprehensive inhibition study of PL pro CoV2. In the case of PL pro SARS, none of the presented ebselen derivatives was able to block the enzyme. Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design Ebselen as a highly active inhibitor of PL pro CoV2	./cache/cord-355811-aq7p1uxo.txt	./txt/cord-355811-aq7p1uxo.txt