id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-356090-oj3d9ail	Gorgun, D.	Binding Mode of SARS-CoV2 Fusion Peptide to Human Cellular Membrane	2020-10-27		.txt	text/plain	6065	277	51	Here, we use an array of molecular dynamics (MD) simulations taking advantage of the Highly Mobile Membrane Mimetic (HMMM) model, to investigate the interaction of the SARS-CoV2 FP with a lipid bilayer representing mammalian cellular membranes at an atomic level, and to characterize the membrane-bound form of the peptide. Taken into account the sequence conservation among the viral FPs and the results of mutagenesis studies establishing the role of specific residues in the helical portion of the FP in membrane association, we propose that the helix-binding mode represents more closely the biologically relevant form. In this study, using molecular dynamics simulations, we describe how the fusion peptide from the SARS-CoV2 virus binds human cellular membranes and characterize, at an atomic level, lipid-protein interactions important for the stability of the bound state. In this study, using a large set of simulations, we describe how the SARS-CoV2 FP binds mammalian cellular membranes and characterize, at atomic details, lipid-protein interactions important for the stability of the bound state.	./cache/cord-356090-oj3d9ail.txt	./txt/cord-356090-oj3d9ail.txt