id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343165-la5sy0vq	Liu, Chuanmin	Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo	2017-02-21		.txt	text/plain	4857	256	56	This study was conducted to investigate the antiviral activity of NO generated from S-nitrosoglutathione (GSNO), during PCV2 infection of PK-15 cells and BALB/c mice. NO strongly inhibited PCV2 replication in PK-15 cells, and the antiviral effect was reversed by Hb. An in vivo assay indicated that GSNO treatment reduced the progression of PCV2 infection in mice, evident as reductions in the percentages of PCV2-positive sera and tissue samples and in the viral DNA copies in serum samples. CONCLUSIONS: Our data demonstrate that the NO-generating compound GSNO suppresses PCV2 infection in PK-15 cells and BALB/c mice, indicating that NO and its donor, GSNO, have potential value as antiviral drugs against PCV2 infection. The antiviral activity of GSNO was determined from the appearance of PCV2-infected cells, viral titers, and PCV2 DNA copy numbers. In this study, we verified the antiviral activity of the NOgenerating compound GSNO during PCV2 infection in PK-15 cells and BALB/c mice.	./cache/cord-343165-la5sy0vq.txt	./txt/cord-343165-la5sy0vq.txt