id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253259-hmn7mg8j	Shaw, A. L.	Three-dimensional visualization of the rotavirus hemagglutinin structure	1993-08-27		.txt	text/plain	5986	332	52	Abstract Three-dimensional structures of a native simian and reassortant rotavirus have been determined by electron cryomicroscopy and computer image processing. The structural features of the native virus confirm that the hemagglutinin spike is a dimer of VP4, substantiated by in vivo radiolabeling studies. The difference map between the two structures reveals a novel large globular domain of VP4 buried within the virion that interacts extensively with the intermediate shell protein, VP6. Our results suggest that assembly of VP4 precedes that of VP7, the major outer shell protein, and that VP4 may play an important role in the receptor recognition and budding process through the rough endoplasmic reticulum during virus maturation. Figure 3A shows a surface representation of the The reconstructed density map of SAI 1-4F reveals the complex organization of the outer shell of rotavirus.	./cache/cord-253259-hmn7mg8j.txt	./txt/cord-253259-hmn7mg8j.txt