id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272520-7mci4mip	Goepfert, P. A.	Identification of an ER retrieval signal in a retroviral glycoprotein	1995-08-25		.txt	text/plain	1212	60	46	To mediate budding of infectious viral particles through intracellular membranes, viral glycoproteins must fulfill two requirements: a signal for sorting to an intracellular compartment and an interaction with the core proteins of the virus. Similar to certain classic oncoviruses, the foamy viruses utilize a B/D-type virus assembly strategy by which immature viral capsids assemble in the cytoplasm in advance of virion budding (Achong et al., 1971; Hooks and Gibbs, 1975) . We hypothesized that foamy virus glycoproteins must possess a specific signal for sorting to an intracellular compartment of the secretory pathway. Remarkably, we identified the dilysine ER retrieval signal at the cytoplasmic carboxyl termini of four of the five available foamy virus glycoprotein sequences ( Table 2 ). If the glycoprotein cytoplasmic tails interact with preassembled viral capsids, which may localize to the same intracellular site, coordinated budding of glycoprotein-bearing infectious virus particles into an early post-ER compartment results.	./cache/cord-272520-7mci4mip.txt	./txt/cord-272520-7mci4mip.txt