id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305290-xnjwv0d7	Atkins, John F.	Ribosome gymnastics—Degree of difficulty 9.5, style 10.0	1990-08-10		.txt	text/plain	7996	417	62	A single base change in the mouse mammary tumor virus (MMTV) gag-pro shift site, from the normal A AAA AAC to A AAA AAG, surprisingly leads from ~2% to 50% -1 frameshifting at this sequence (a 25-fold increase); and the lo-fold decrease between A AAA AAG and A AAA AAA affords an interesting glimpse at how the nuances of codon-anticodon interaction can govern the efficiency of this type of shifting. These results should be interpreted with caution, as all the higher eukaryotic frameshifting studies with altered sequences have been done with a reticulocyte lysate cell-free translation system; there are likely to be differences in the number of ribosomes loaded per message, and perhaps in the tRNA balance, from less specialized cells in vivo.	./cache/cord-305290-xnjwv0d7.txt	./txt/cord-305290-xnjwv0d7.txt