Questions

This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.

identifier question
cord-267046-ewnjgps5Virus Evolution: How Does an Enveloped Virus Make a Regular Structure?
cord-256156-mywhe6w9How good is automated protein docking?
cord-256156-mywhe6w9True Receptors or Adaptation Bias?
cord-255856-0xqllbzz( Bleil and Wassarman, 1980a; f?
cord-284609-1q75zw6bIs the process limited to picornaviruses?
cord-284609-1q75zw6bWhat purpose does RNA recombination serve?
cord-266480-u8o4eituThree family members charged in shooting death of security guard who told a customer to put on a face mask Should schools reopen?
cord-266480-u8o4eituWhy do some COVID-19 patients infect many others, whereas most do n't spread the virus at all?
cord-253259-hmn7mg8jOne pending question is, at what stage does VP4 assembly take place, before or after the assembly of VP7?
cord-253259-hmn7mg8jOne pertinent question is, to what advantage is this asymmetry?
cord-305173-95o5z685Finally, does dysregulation of cutaneous blood flow have any effect on body temperature homeostasis?
cord-263468-996kl9jzA Biased RNA Polymerase?
cord-263468-996kl9jzDoes the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA?
cord-263468-996kl9jzTo test this hypothesis, we sequenced the complete N gene and one third to one half of the f?
cord-279463-bli8hwdaHow can we possibly explain how the deletion of the cytoplasmic, hydrophilic segment from IyCAT reveals a cleavable signal sequence in a formerly membranespanning region?
cord-259681-k9cnikqkHSVI proteins were labeled for 10 min with?
cord-259681-k9cnikqkIn parallel, monolayers were labeled for 10 min with?
cord-318276-so5jooj0Borst, l?( 1986).
cord-318276-so5jooj0How do eucaryotic ribosomes select initiation regions in messenger RNA?
cord-307021-uppekume( C)[ 35S]proOmpA was renatured by dilution into translocation mixtures( without membranes) that contained the indicated amounts of purified trigger factor or o- aminopentyl agarose- isolated SRI?
cord-307021-uppekumeA close analogy can be drawn between trigger factor and the SRI?
cord-272520-7mci4mipWhat mechanisms cause the foamy viruses to bud at intracellular membranes, a site of maturation that is unusual among infectious retroviruses?
cord-271032-imc6wohtCOVID-19: a double- edged sword?
cord-271032-imc6wohtFighting on the Front 1761 Lines or Fanning the Flames of COVID-19?
cord-271032-imc6wohtShould we stimulate or suppress immune responses in COVID-19? 1663 Cytokine and anti- cytokine interventions Gene List to a Gene Regulatory Network Using Large Motif and Track Collections Heterogeneity among septic shock patients in a 1670 set of immunoregulatory markers Human suppressive neutrophils
cord-291790-z5rwznmvWhich Genetic 594 Mutations Are Antigenically Important?
cord-291790-z5rwznmvWhy are RNA virus mutation rates so damn high?
cord-327349-rxb6zfocIs checkpoint blockade a friend or foe in the context of COVID-19?
cord-252433-0e9lonq4But how do viruses use noncoding RNAs to promote their replication?
cord-252433-0e9lonq4So which factors are required for the export of cellular mRNAs?
cord-252433-0e9lonq4So, why is this uncapped viral mRNA translated more efficiently than capped cellular mRNAs?
cord-252433-0e9lonq4mRNAs reach the cytoplasm?
cord-270082-byxd4o4mKinetochore Aid the Understanding of Kinetochore Function in More Complex Eukaryotes?
cord-305290-xnjwv0d7Belcourt, M. F., and Farabaugh, I? J.( 1990).
cord-305290-xnjwv0d7Chang, L.-J., Pryciak, t?, Ganem, D.. and Varmus, H. E.( 1989.
cord-339093-mwxkvwazEngineered Autonomous Human Variable Domains Antiviral Monoclonal Antibodies: Can They Be More Than Simple Neutralizing Agents?
cord-312115-foy3dsq4CD8+ T cells with a naive- like profile upon yellow fever vaccination Targets of T Cell Responses to SARS- CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals Clinical Characteristics of Coronavirus Disease 2019 in China Has Sweden's controversial covid-19 strategy been successful?
cord-312115-foy3dsq4The key to harmonization in serological SARS- CoV-2 assays?
cord-312115-foy3dsq4Will antibody tests for the coronavirus really change everything?
cord-321308-rwxhdg8rDid SARS- CoV-2 evolve to become better adapted to humans?
cord-321308-rwxhdg8rMore deadly?
cord-321308-rwxhdg8rMore infectious or transmissible?
cord-328289-3h3kmjlzCan Covid Damage the Brain?
cord-328289-3h3kmjlzDoes the brain contribute to respiratory failure and hypertension?
cord-328289-3h3kmjlzDoes the brain contribute to the immune dysregulation?
cord-328289-3h3kmjlzHere are some of the outstanding questions: Do the neurological manifestations of COVID-19 reflect brain invasion?
cord-328289-3h3kmjlzWhat are the long- term neurological and neuropsychiatric consequences of COVID-19?
cord-321868-xk4yuibjGene 46, 145- 152.Donahue, T. F., Farabaugh, f? J., and Fink, G. R.( 1982).
cord-321868-xk4yuibjHow is this level of"inaccuracy"achieved?
cord-321868-xk4yuibjIf the AGG codon of the frameshift site induces a translational pause as a result of the low availability of its cognate tRNA, is it possible to induce a translational pause by substituting a codon recognized by other low- abundance tRNAs?
cord-321868-xk4yuibjIs frameshifting constrained to occur in only one direction, or can it occur in either direction?
cord-321868-xk4yuibjNature 288, 60- 63.Gafner, J., De Robertis, E. M., and Philippsen, f?
cord-321868-xk4yuibjTy element transposition: reverse transcriptase and virus- like particles, Cell 42, 507- 517.Guarente, L., Yocum, R., and Gifford, t?( 1982).
cord-321868-xk4yuibjWe thank i?
cord-321868-xk4yuibjWill frameshifting occur only when the TYA reading frame is being translated by the ribosome?
cord-287815-alv30uk5Anyway?
cord-287815-alv30uk5Are There?
cord-287815-alv30uk5Are compartment boundaries defined by specific protein frameworks?
cord-287815-alv30uk5Does Transport through the Golgi Require Vesicular Carriers?
cord-287815-alv30uk5Does transport between Golgi compartments require vesicular carriers?
cord-287815-alv30uk5How Good Is the Evidence for the Current View of the Golgi?
cord-287815-alv30uk5How do microtubules interact with the Golgi elements?
cord-287815-alv30uk5How does lipid composition and organization affect transport?
cord-287815-alv30uk5How does the machinery responsible for forward traffic relate to the machinery controlling homotypic fusion?
cord-287815-alv30uk5How is specificity of forward and backward traffic regulated?
cord-287815-alv30uk5How many Golgi compartments are there?
cord-287815-alv30uk5If so, how do they function and how are they regulated?
cord-287815-alv30uk5If the medial Golgi serves only to mediate glycosylation reactions, why the characteristic cisternal morphology?
cord-287815-alv30uk5If vesicles are not involved, is transfer from donor to acceptor Golgi mediated by direct fusion, perhaps via tubular extensions?
cord-287815-alv30uk5In vitro veritas?
cord-287815-alv30uk5Is Transport through the Golgi Selective or Nonselective?
cord-287815-alv30uk5Is transport in vitro ever completely dependent on vesicle formation, even in the absence of BFA?
cord-287815-alv30uk5The fact that"transport"( i.e., G protein glycosylation) can occur in the absence of vesicle formation raises a number of important questions: What transport step(s) is actually being measured in vitro?
cord-287815-alv30uk5Vesicular Transport or Golgi Fusion?
cord-287815-alv30uk5What function does the stack structure have?
cord-287815-alv30uk5What is the relationship of the events reconstituted in vitro to those found in intact cells?
cord-287815-alv30uk5What is the role of tubules?
cord-287815-alv30uk5While transport vesicles may represent the most likely mechanism to accomplish transfer between compartments and/or individual cisternae, how strong is the evidence that they actually perform this function?
cord-269023-g21a9ik2A dwindling, dispensable, involuting organ; how could it possibly be essential for human ll lives?
cord-269023-g21a9ik2And could such re- infected individuals carry enough virus to infect the immunologically naive population?
cord-269023-g21a9ik2And second: is it infected with a virus or a bacterium?
cord-269023-g21a9ik2And so this essay looks back at history- of virology, vaccinations, and immunology- and asks: what have we learned, and what must be revisited?
cord-269023-g21a9ik2And what about T cells?
cord-269023-g21a9ik2Are there host factors that predict severe disease?
cord-269023-g21a9ik2But how did inoculation generate immunity, particularly longterm immunity?
cord-269023-g21a9ik2But how does a CD8 cell find a self- cell with a virus embedded within it?
cord-269023-g21a9ik2But if B cells generate antibodies to kill microbes, what do T cells do( Miller, 2020)?
cord-269023-g21a9ik2But might it have a function during fetal development?
cord-269023-g21a9ik2Can they be re- infected- and if so, would they suffer milder disease?
cord-269023-g21a9ik2Could these people be partially protected?
cord-269023-g21a9ik2Do individuals with low- titer antibodies have fewer memory B cells to combat a future infection?
cord-269023-g21a9ik2Does it influence the efficacy or durability of the vaccine?
cord-269023-g21a9ik2Does it matter?
cord-269023-g21a9ik2Edward Jenner or Benjamin Jesty?
cord-269023-g21a9ik2Finally: what about the diffuse, systemic manifestations of SARS- CoV-2 infection?
cord-269023-g21a9ik2First: does the cell that I am surveying belong to my body?
cord-269023-g21a9ik2First: what determines the strength and durability of an immune response to the virus?
cord-269023-g21a9ik2How could you detect a resident inside one of these houses, unless the resident happened to poke his head outside?''
cord-269023-g21a9ik2How does the coronavirus behave inside a patient?
cord-269023-g21a9ik2How, then, was the T cell detecting NP?
cord-269023-g21a9ik2I interferon activity and inflammatory responses in severe COVID-19 patients Who discovered smallpox vaccination?
cord-269023-g21a9ik2In other words, is there a difference between the infected and the infectious( if so, more stringent isolation protocols might be deployed on those that are infectious until they clear the virus)?
cord-269023-g21a9ik2More generally, why do infections by some viruses, or inoculation with some vaccines, precipitate durable, long- term responses, while the immunity to others wanes over time, causing re- infections, and requiring''boosters''for continuous immunity?
cord-269023-g21a9ik2Novel Virus and Novel Case Do Antigens Bear Instructions for antibody specificity, or do they select cell lines that arise by mutation?
cord-269023-g21a9ik2Or take an even more basic question that has enormous epidemiological and public policy significance: is there a level, or threshold, of viral load that a patient must carry in order to infect others?
cord-269023-g21a9ik2Second: why do some people recover from infection, while others progress to a fulminant, deadly disease?
cord-269023-g21a9ik2What if he stuck a thorn in one of the starfish's feet?
cord-269023-g21a9ik2What if, Burnet reasoned, every B cell expressed only one antibody?
cord-269023-g21a9ik2What words does one use- what phrases- to adequately capture the difference in living in the BV versus the AV- Before Virus and After Virus?
cord-269023-g21a9ik2Where did these antibodies come from?
cord-269023-g21a9ik2Why?
cord-269023-g21a9ik2do they select cell lines[ that are specific for the antigen- i.e. by clonal selection]''?