id sid tid token lemma pos cord-287815-alv30uk5 1 1 key key NNP cord-287815-alv30uk5 1 2 : : : cord-287815-alv30uk5 1 3 cord-287815-alv30uk5 cord-287815-alv30uk5 NNP cord-287815-alv30uk5 2 1 authors author NNS cord-287815-alv30uk5 2 2 : : : cord-287815-alv30uk5 2 3 Mellman Mellman NNP cord-287815-alv30uk5 2 4 , , , cord-287815-alv30uk5 2 5 Ira Ira NNP cord-287815-alv30uk5 2 6 ; ; : cord-287815-alv30uk5 2 7 Simons Simons NNP cord-287815-alv30uk5 2 8 , , , cord-287815-alv30uk5 3 1 Kai Kai NNP cord-287815-alv30uk5 3 2 title title NN cord-287815-alv30uk5 3 3 : : : cord-287815-alv30uk5 4 1 The the DT cord-287815-alv30uk5 4 2 Golgi Golgi NNP cord-287815-alv30uk5 4 3 complex complex NN cord-287815-alv30uk5 4 4 : : : cord-287815-alv30uk5 5 1 In in IN cord-287815-alv30uk5 5 2 vitro vitro FW cord-287815-alv30uk5 5 3 veritas veritas FW cord-287815-alv30uk5 5 4 ? ? . cord-287815-alv30uk5 6 1 date date NN cord-287815-alv30uk5 6 2 : : : cord-287815-alv30uk5 6 3 1992 1992 CD cord-287815-alv30uk5 6 4 - - HYPH cord-287815-alv30uk5 6 5 03 03 CD cord-287815-alv30uk5 6 6 - - HYPH cord-287815-alv30uk5 6 7 06 06 CD cord-287815-alv30uk5 6 8 journal journal NN cord-287815-alv30uk5 6 9 : : : cord-287815-alv30uk5 7 1 Cell cell NN cord-287815-alv30uk5 7 2 DOI doi NN cord-287815-alv30uk5 7 3 : : : cord-287815-alv30uk5 7 4 10.1016/0092 10.1016/0092 CD cord-287815-alv30uk5 7 5 - - HYPH cord-287815-alv30uk5 7 6 8674(92)90027-a 8674(92)90027-a CD cord-287815-alv30uk5 7 7 sha sha NNP cord-287815-alv30uk5 7 8 : : : cord-287815-alv30uk5 8 1 a80bc93a9b4851d9f4925885f9436f3739781333 a80bc93a9b4851d9f4925885f9436f3739781333 NNP cord-287815-alv30uk5 8 2 doc_id doc_id CD cord-287815-alv30uk5 8 3 : : : cord-287815-alv30uk5 9 1 287815 287815 CD cord-287815-alv30uk5 9 2 cord_uid cord_uid NNS cord-287815-alv30uk5 9 3 : : : cord-287815-alv30uk5 10 1 alv30uk5 alv30uk5 NNP cord-287815-alv30uk5 10 2 nan nan NNP cord-287815-alv30uk5 10 3 iplex iplex NNP cord-287815-alv30uk5 10 4 has have VBZ cord-287815-alv30uk5 10 5 proved prove VBN cord-287815-alv30uk5 10 6 to to TO cord-287815-alv30uk5 10 7 be be VB cord-287815-alv30uk5 10 8 among among IN cord-287815-alv30uk5 10 9 the the DT cord-287815-alv30uk5 10 10 more more RBR cord-287815-alv30uk5 10 11 challenging challenging JJ cord-287815-alv30uk5 10 12 probllems probllem NNS cord-287815-alv30uk5 10 13 in in IN cord-287815-alv30uk5 10 14 cell cell NN cord-287815-alv30uk5 10 15 biology biology NN cord-287815-alv30uk5 10 16 . . . cord-287815-alv30uk5 11 1 The the DT cord-287815-alv30uk5 11 2 last last JJ cord-287815-alv30uk5 11 3 several several JJ cord-287815-alv30uk5 11 4 years year NNS cord-287815-alv30uk5 11 5 have have VBP cord-287815-alv30uk5 11 6 turned turn VBN cord-287815-alv30uk5 11 7 out out RP cord-287815-alv30uk5 11 8 Ito Ito NNP cord-287815-alv30uk5 11 9 be be VB cord-287815-alv30uk5 11 10 particularly particularly RB cord-287815-alv30uk5 11 11 exciting exciting JJ cord-287815-alv30uk5 11 12 in in IN cord-287815-alv30uk5 11 13 this this DT cord-287815-alv30uk5 11 14 respect respect NN cord-287815-alv30uk5 11 15 since since IN cord-287815-alv30uk5 11 16 they -PRON- PRP cord-287815-alv30uk5 11 17 have have VBP cord-287815-alv30uk5 11 18 Iyielded iyielde VBN cord-287815-alv30uk5 11 19 new new JJ cord-287815-alv30uk5 11 20 insights insight NNS cord-287815-alv30uk5 11 21 and and CC cord-287815-alv30uk5 11 22 ideas idea NNS cord-287815-alv30uk5 11 23 at at IN cord-287815-alv30uk5 11 24 an an DT cord-287815-alv30uk5 11 25 increasingly increasingly RB cord-287815-alv30uk5 11 26 rapid rapid JJ cord-287815-alv30uk5 11 27 ipace ipace NN cord-287815-alv30uk5 11 28 . . . cord-287815-alv30uk5 12 1 This this DT cord-287815-alv30uk5 12 2 period period NN cord-287815-alv30uk5 12 3 of of IN cord-287815-alv30uk5 12 4 advance advance NN cord-287815-alv30uk5 12 5 has have VBZ cord-287815-alv30uk5 12 6 largely largely RB cord-287815-alv30uk5 12 7 been be VBN cord-287815-alv30uk5 12 8 due due JJ cord-287815-alv30uk5 12 9 to to IN cord-287815-alv30uk5 12 10 the the DT cord-287815-alv30uk5 12 11 Idevelopment Idevelopment NNP cord-287815-alv30uk5 12 12 of of IN cord-287815-alv30uk5 12 13 powerful powerful JJ cord-287815-alv30uk5 12 14 new new JJ cord-287815-alv30uk5 12 15 biochemical biochemical JJ cord-287815-alv30uk5 12 16 , , , cord-287815-alv30uk5 12 17 morphological morphological JJ cord-287815-alv30uk5 12 18 , , , cord-287815-alv30uk5 12 19 # # NN cord-287815-alv30uk5 12 20 and and CC cord-287815-alv30uk5 12 21 genetic genetic JJ cord-287815-alv30uk5 12 22 approaches approach NNS cord-287815-alv30uk5 12 23 to to IN cord-287815-alv30uk5 12 24 unraveling unravel VBG cord-287815-alv30uk5 12 25 the the DT cord-287815-alv30uk5 12 26 complexities complexity NNS cord-287815-alv30uk5 12 27 of of IN cord-287815-alv30uk5 12 28 ' ' '' cord-287815-alv30uk5 12 29 this this DT cord-287815-alv30uk5 12 30 organelle organelle NN cord-287815-alv30uk5 12 31 . . . cord-287815-alv30uk5 13 1 While while IN cord-287815-alv30uk5 13 2 much much JJ cord-287815-alv30uk5 13 3 remains remain VBZ cord-287815-alv30uk5 13 4 to to TO cord-287815-alv30uk5 13 5 be be VB cord-287815-alv30uk5 13 6 discovered discover VBN cord-287815-alv30uk5 13 7 , , , cord-287815-alv30uk5 13 8 the the DT cord-287815-alv30uk5 13 9 Iproblem Iproblem NNP cord-287815-alv30uk5 13 10 now now RB cord-287815-alv30uk5 13 11 is be VBZ cord-287815-alv30uk5 13 12 how how WRB cord-287815-alv30uk5 13 13 to to TO cord-287815-alv30uk5 13 14 integrate integrate VB cord-287815-alv30uk5 13 15 this this DT cord-287815-alv30uk5 13 16 wealth wealth NN cord-287815-alv30uk5 13 17 of of IN cord-287815-alv30uk5 13 18 information information NN cord-287815-alv30uk5 13 19 . . . cord-287815-alv30uk5 13 20 ' ' '' cord-287815-alv30uk5 14 1 To to TO cord-287815-alv30uk5 14 2 see see VB cord-287815-alv30uk5 14 3 if if IN cord-287815-alv30uk5 14 4 this this DT cord-287815-alv30uk5 14 5 is be VBZ cord-287815-alv30uk5 14 6 possible possible JJ cord-287815-alv30uk5 14 7 , , , cord-287815-alv30uk5 14 8 we -PRON- PRP cord-287815-alv30uk5 14 9 will will MD cord-287815-alv30uk5 14 10 first first RB cord-287815-alv30uk5 14 11 summarize summarize VB cord-287815-alv30uk5 14 12 how how WRB cord-287815-alv30uk5 14 13 the the DT cord-287815-alv30uk5 14 14 lslolgi lslolgi NN cord-287815-alv30uk5 14 15 is be VBZ cord-287815-alv30uk5 14 16 commonly commonly RB cord-287815-alv30uk5 14 17 believed believe VBN cord-287815-alv30uk5 14 18 to to TO cord-287815-alv30uk5 14 19 work work VB cord-287815-alv30uk5 14 20 and and CC cord-287815-alv30uk5 14 21 then then RB cord-287815-alv30uk5 14 22 evaluate evaluate VB cord-287815-alv30uk5 14 23 the the DT cord-287815-alv30uk5 14 24 lstrength lstrength NN cord-287815-alv30uk5 14 25 of of IN cord-287815-alv30uk5 14 26 the the DT cord-287815-alv30uk5 14 27 evidence evidence NN cord-287815-alv30uk5 14 28 that that WDT cord-287815-alv30uk5 14 29 underlies underlie VBZ cord-287815-alv30uk5 14 30 these these DT cord-287815-alv30uk5 14 31 views view NNS cord-287815-alv30uk5 14 32 . . . cord-287815-alv30uk5 15 1 Present present JJ cord-287815-alv30uk5 15 2 View view NN cord-287815-alv30uk5 15 3 of of IN cord-287815-alv30uk5 15 4 the the DT cord-287815-alv30uk5 15 5 Golgi Golgi NNP cord-287815-alv30uk5 15 6 ' ' `` cord-287815-alv30uk5 15 7 The the DT cord-287815-alv30uk5 15 8 Golgi Golgi NNP cord-287815-alv30uk5 15 9 complex complex NN cord-287815-alv30uk5 15 10 is be VBZ cord-287815-alv30uk5 15 11 essentially essentially RB cord-287815-alv30uk5 15 12 a a DT cord-287815-alv30uk5 15 13 carbohydrate carbohydrate NN cord-287815-alv30uk5 15 14 factory factory NN cord-287815-alv30uk5 15 15 . . . cord-287815-alv30uk5 16 1 In in IN cord-287815-alv30uk5 16 2 < < NNP cord-287815-alv30uk5 16 3 animal animal NN cord-287815-alv30uk5 16 4 cells cell NNS cord-287815-alv30uk5 16 5 , , , cord-287815-alv30uk5 16 6 it -PRON- PRP cord-287815-alv30uk5 16 7 is be VBZ cord-287815-alv30uk5 16 8 engaged engage VBN cord-287815-alv30uk5 16 9 in in IN cord-287815-alv30uk5 16 10 the the DT cord-287815-alv30uk5 16 11 biosynthesisof biosynthesisof NNP cord-287815-alv30uk5 16 12 glycolipids glycolipid NNS cord-287815-alv30uk5 16 13 ( ( -LRB- cord-287815-alv30uk5 16 14 and and CC cord-287815-alv30uk5 16 15 of of IN cord-287815-alv30uk5 16 16 oligosaccharide oligosaccharide JJ cord-287815-alv30uk5 16 17 portions portion NNS cord-287815-alv30uk5 16 18 of of IN cord-287815-alv30uk5 16 19 glycoproteins glycoprotein NNS cord-287815-alv30uk5 16 20 and and CC cord-287815-alv30uk5 16 21 proteoglycans proteoglycan NNS cord-287815-alv30uk5 16 22 . . . cord-287815-alv30uk5 17 1 In in IN cord-287815-alv30uk5 17 2 plant plant NN cord-287815-alv30uk5 17 3 cells cell NNS cord-287815-alv30uk5 17 4 , , , cord-287815-alv30uk5 17 5 it -PRON- PRP cord-287815-alv30uk5 17 6 has have VBZ cord-287815-alv30uk5 17 7 the the DT cord-287815-alv30uk5 17 8 additional additional JJ cord-287815-alv30uk5 17 9 task task NN cord-287815-alv30uk5 17 10 of of IN cord-287815-alv30uk5 17 11 producing produce VBG cord-287815-alv30uk5 17 12 a a DT cord-287815-alv30uk5 17 13 wide wide JJ cord-287815-alv30uk5 17 14 range range NN cord-287815-alv30uk5 17 15 of of IN cord-287815-alv30uk5 17 16 extracellular extracellular JJ cord-287815-alv30uk5 17 17 polysaccharides polysaccharide NNS cord-287815-alv30uk5 17 18 . . . cord-287815-alv30uk5 18 1 The the DT cord-287815-alv30uk5 18 2 factory factory NN cord-287815-alv30uk5 18 3 receives receive VBZ cord-287815-alv30uk5 18 4 its -PRON- PRP$ cord-287815-alv30uk5 18 5 substrates substrate NNS cord-287815-alv30uk5 18 6 for for IN cord-287815-alv30uk5 18 7 glycosylation glycosylation NN cord-287815-alv30uk5 18 8 from from IN cord-287815-alv30uk5 18 9 the the DT cord-287815-alv30uk5 18 10 iendoplasmic iendoplasmic JJ cord-287815-alv30uk5 18 11 reticulum reticulum NN cord-287815-alv30uk5 18 12 ( ( -LRB- cord-287815-alv30uk5 18 13 ER ER NNP cord-287815-alv30uk5 18 14 ) ) -RRB- cord-287815-alv30uk5 18 15 , , , cord-287815-alv30uk5 18 16 transports transport VBZ cord-287815-alv30uk5 18 17 its -PRON- PRP$ cord-287815-alv30uk5 18 18 raw raw JJ cord-287815-alv30uk5 18 19 materials material NNS cord-287815-alv30uk5 18 20 ( ( -LRB- cord-287815-alv30uk5 18 21 monosaccharide monosaccharide NN cord-287815-alv30uk5 18 22 precursors precursor NNS cord-287815-alv30uk5 18 23 ) ) -RRB- cord-287815-alv30uk5 18 24 in in IN cord-287815-alv30uk5 18 25 from from IN cord-287815-alv30uk5 18 26 the the DT cord-287815-alv30uk5 18 27 cytosol cytosol NN cord-287815-alv30uk5 18 28 , , , cord-287815-alv30uk5 18 29 and and CC cord-287815-alv30uk5 18 30 dis-,tributes dis-,tribute VBZ cord-287815-alv30uk5 18 31 its -PRON- PRP$ cord-287815-alv30uk5 18 32 completed complete VBN cord-287815-alv30uk5 18 33 protein protein NN cord-287815-alv30uk5 18 34 , , , cord-287815-alv30uk5 18 35 lipid lipid NN cord-287815-alv30uk5 18 36 , , , cord-287815-alv30uk5 18 37 and and CC cord-287815-alv30uk5 18 38 polysaccharide polysaccharide NN cord-287815-alv30uk5 18 39 Iproducts Iproducts NNP cord-287815-alv30uk5 18 40 to to IN cord-287815-alv30uk5 18 41 a a DT cord-287815-alv30uk5 18 42 variety variety NN cord-287815-alv30uk5 18 43 of of IN cord-287815-alv30uk5 18 44 destinations destination NNS cord-287815-alv30uk5 18 45 . . . cord-287815-alv30uk5 18 46 ' ' '' cord-287815-alv30uk5 19 1 Transport transport NN cord-287815-alv30uk5 19 2 through through IN cord-287815-alv30uk5 19 3 the the DT cord-287815-alv30uk5 19 4 Golgi Golgi NNP cord-287815-alv30uk5 19 5 Is be VBZ cord-287815-alv30uk5 19 6 Directional directional JJ cord-287815-alv30uk5 20 1 ( ( -LRB- cord-287815-alv30uk5 20 2 One one CD cord-287815-alv30uk5 20 3 of of IN cord-287815-alv30uk5 20 4 the the DT cord-287815-alv30uk5 20 5 most most RBS cord-287815-alv30uk5 20 6 compelling compelling JJ cord-287815-alv30uk5 20 7 features feature NNS cord-287815-alv30uk5 20 8 of of IN cord-287815-alv30uk5 20 9 the the DT cord-287815-alv30uk5 20 10 Golgi Golgi NNP cord-287815-alv30uk5 20 11 complex complex NN cord-287815-alv30uk5 20 12 , , , cord-287815-alv30uk5 20 13 IS be VBZ cord-287815-alv30uk5 20 14 its -PRON- PRP$ cord-287815-alv30uk5 20 15 structure structure NN cord-287815-alv30uk5 20 16 . . . cord-287815-alv30uk5 21 1 In in IN cord-287815-alv30uk5 21 2 electron electron NN cord-287815-alv30uk5 21 3 micrographs micrograph NNS cord-287815-alv30uk5 21 4 , , , cord-287815-alv30uk5 21 5 the the DT cord-287815-alv30uk5 21 6 Golgi Golgi NNP cord-287815-alv30uk5 21 7 is be VBZ cord-287815-alv30uk5 21 8 seen see VBN cord-287815-alv30uk5 21 9 # # $ cord-287815-alv30uk5 21 10 as as IN cord-287815-alv30uk5 21 11 a a DT cord-287815-alv30uk5 21 12 set set NN cord-287815-alv30uk5 21 13 of of IN cord-287815-alv30uk5 21 14 flattened flatten VBN cord-287815-alv30uk5 21 15 cisternae cisternae NN cord-287815-alv30uk5 21 16 with with IN cord-287815-alv30uk5 21 17 dilated dilated JJ cord-287815-alv30uk5 21 18 rims rim NNS cord-287815-alv30uk5 21 19 arranged arrange VBN cord-287815-alv30uk5 21 20 llike llike VBP cord-287815-alv30uk5 21 21 a a DT cord-287815-alv30uk5 21 22 stack stack NN cord-287815-alv30uk5 21 23 . . . cord-287815-alv30uk5 22 1 The the DT cord-287815-alv30uk5 22 2 cisternae cisternae NN cord-287815-alv30uk5 22 3 are be VBP cord-287815-alv30uk5 22 4 also also RB cord-287815-alv30uk5 22 5 associated associate VBN cord-287815-alv30uk5 22 6 with with IN cord-287815-alv30uk5 22 7 an an DT cord-287815-alv30uk5 22 8 # # $ cord-287815-alv30uk5 22 9 array array NN cord-287815-alv30uk5 22 10 of of IN cord-287815-alv30uk5 22 11 small small JJ cord-287815-alv30uk5 22 12 vesicles vesicle NNS cord-287815-alv30uk5 22 13 , , , cord-287815-alv30uk5 22 14 as as RB cord-287815-alv30uk5 22 15 well well RB cord-287815-alv30uk5 22 16 as as IN cord-287815-alv30uk5 22 17 with with IN cord-287815-alv30uk5 22 18 a a DT cord-287815-alv30uk5 22 19 network network NN cord-287815-alv30uk5 22 20 of of IN cord-287815-alv30uk5 22 21 tubules tubule NNS cord-287815-alv30uk5 22 22 ( ( -LRB- cord-287815-alv30uk5 22 23 emanating emanate VBG cord-287815-alv30uk5 22 24 from from IN cord-287815-alv30uk5 22 25 both both DT cord-287815-alv30uk5 22 26 sides side NNS cord-287815-alv30uk5 22 27 of of IN cord-287815-alv30uk5 22 28 the the DT cord-287815-alv30uk5 22 29 stack stack NN cord-287815-alv30uk5 22 30 ( ( -LRB- cord-287815-alv30uk5 22 31 Figure figure NN cord-287815-alv30uk5 22 32 1 1 CD cord-287815-alv30uk5 22 33 ) ) -RRB- cord-287815-alv30uk5 22 34 . . . cord-287815-alv30uk5 23 1 Morphologically morphologically RB cord-287815-alv30uk5 23 2 and and CC cord-287815-alv30uk5 23 3 functionally functionally RB cord-287815-alv30uk5 23 4 , , , cord-287815-alv30uk5 23 5 the the DT cord-287815-alv30uk5 23 6 Golgi Golgi NNP cord-287815-alv30uk5 23 7 complex complex NN cord-287815-alv30uk5 23 8 has have VBZ cord-287815-alv30uk5 23 9 a a DT cord-287815-alv30uk5 23 10 distinct distinct JJ cord-287815-alv30uk5 23 11 , , , cord-287815-alv30uk5 23 12 polarity polarity NN cord-287815-alv30uk5 23 13 ( ( -LRB- cord-287815-alv30uk5 23 14 Farquhar Farquhar NNP cord-287815-alv30uk5 23 15 and and CC cord-287815-alv30uk5 23 16 Palade Palade NNP cord-287815-alv30uk5 23 17 , , , cord-287815-alv30uk5 23 18 1981 1981 CD cord-287815-alv30uk5 23 19 ) ) -RRB- cord-287815-alv30uk5 23 20 . . . cord-287815-alv30uk5 24 1 Newly newly RB cord-287815-alv30uk5 24 2 synthesized synthesize VBN cord-287815-alv30uk5 24 3 membrane membrane NN cord-287815-alv30uk5 24 4 and and CC cord-287815-alv30uk5 24 5 secretory secretory NN cord-287815-alv30uk5 24 6 proteins protein NNS cord-287815-alv30uk5 24 7 coming come VBG cord-287815-alv30uk5 24 8 from from IN cord-287815-alv30uk5 24 9 the the DT cord-287815-alv30uk5 24 10 ER ER NNP cord-287815-alv30uk5 24 11 enter enter VB cord-287815-alv30uk5 24 12 the the DT cord-287815-alv30uk5 24 13 Golgi Golgi NNP cord-287815-alv30uk5 24 14 through through IN cord-287815-alv30uk5 24 15 the the DT cord-287815-alv30uk5 24 16 cis cis NNP cord-287815-alv30uk5 24 17 face face NN cord-287815-alv30uk5 24 18 , , , cord-287815-alv30uk5 24 19 traverse traverse VB cord-287815-alv30uk5 24 20 across across IN cord-287815-alv30uk5 24 21 the the DT cord-287815-alv30uk5 24 22 stack stack NN cord-287815-alv30uk5 24 23 , , , cord-287815-alv30uk5 24 24 and and CC cord-287815-alv30uk5 24 25 leave leave VB cord-287815-alv30uk5 24 26 via via IN cord-287815-alv30uk5 24 27 the the DT cord-287815-alv30uk5 24 28 trans trans NNP cord-287815-alv30uk5 24 29 face face NN cord-287815-alv30uk5 24 30 . . . cord-287815-alv30uk5 25 1 A a DT cord-287815-alv30uk5 25 2 reticulum reticulum NN cord-287815-alv30uk5 25 3 of of IN cord-287815-alv30uk5 25 4 tubules tubule NNS cord-287815-alv30uk5 25 5 Iemanating Iemanating NNP cord-287815-alv30uk5 25 6 from from IN cord-287815-alv30uk5 25 7 the the DT cord-287815-alv30uk5 25 8 trans trans NNP cord-287815-alv30uk5 25 9 - - JJ cord-287815-alv30uk5 25 10 most most JJS cord-287815-alv30uk5 25 11 cisterna cisterna NNP cord-287815-alv30uk5 25 12 , , , cord-287815-alv30uk5 25 13 collectively collectively RB cord-287815-alv30uk5 25 14 referred refer VBD cord-287815-alv30uk5 25 15 to to IN cord-287815-alv30uk5 25 16 as as IN cord-287815-alv30uk5 25 17 the the DT cord-287815-alv30uk5 25 18 trans trans NNP cord-287815-alv30uk5 25 19 - - NNP cord-287815-alv30uk5 25 20 Golgi Golgi NNP cord-287815-alv30uk5 25 21 network network NN cord-287815-alv30uk5 25 22 ( ( -LRB- cord-287815-alv30uk5 25 23 TGN TGN NNP cord-287815-alv30uk5 25 24 ) ) -RRB- cord-287815-alv30uk5 25 25 or or CC cord-287815-alv30uk5 25 26 trans trans JJ cord-287815-alv30uk5 25 27 - - JJ cord-287815-alv30uk5 25 28 Golgi Golgi NNP cord-287815-alv30uk5 25 29 reticulum reticulum NN cord-287815-alv30uk5 25 30 , , , cord-287815-alv30uk5 25 31 probably probably RB cord-287815-alv30uk5 25 32 reflects reflect VBZ cord-287815-alv30uk5 25 33 the the DT cord-287815-alv30uk5 25 34 actual actual JJ cord-287815-alv30uk5 25 35 sites site NNS cord-287815-alv30uk5 25 36 of of IN cord-287815-alv30uk5 25 37 exit exit NN cord-287815-alv30uk5 25 38 ( ( -LRB- cord-287815-alv30uk5 25 39 Griffiths Griffiths NNP cord-287815-alv30uk5 25 40 , , , cord-287815-alv30uk5 25 41 and and CC cord-287815-alv30uk5 25 42 Simons Simons NNP cord-287815-alv30uk5 25 43 , , , cord-287815-alv30uk5 25 44 1986 1986 CD cord-287815-alv30uk5 25 45 ; ; : cord-287815-alv30uk5 25 46 Geuze Geuze NNP cord-287815-alv30uk5 25 47 and and CC cord-287815-alv30uk5 25 48 MorrB MorrB NNP cord-287815-alv30uk5 25 49 , , , cord-287815-alv30uk5 25 50 1991 1991 CD cord-287815-alv30uk5 25 51 ) ) -RRB- cord-287815-alv30uk5 25 52 . . . cord-287815-alv30uk5 26 1 On on IN cord-287815-alv30uk5 26 2 route route NN cord-287815-alv30uk5 26 3 , , , cord-287815-alv30uk5 26 4 through through IN cord-287815-alv30uk5 26 5 the the DT cord-287815-alv30uk5 26 6 Golgi Golgi NNP cord-287815-alv30uk5 26 7 , , , cord-287815-alv30uk5 26 8 newly newly RB cord-287815-alv30uk5 26 9 synthesized synthesize VBN cord-287815-alv30uk5 26 10 glycoproteins glycoprotein NNS cord-287815-alv30uk5 26 11 are be VBP cord-287815-alv30uk5 26 12 subjected subject VBN cord-287815-alv30uk5 26 13 to to IN cord-287815-alv30uk5 26 14 a a DT cord-287815-alv30uk5 26 15 series series NN cord-287815-alv30uk5 26 16 of of IN cord-287815-alv30uk5 26 17 posttranslational posttranslational JJ cord-287815-alv30uk5 26 18 modifications modification NNS cord-287815-alv30uk5 26 19 , , , cord-287815-alv30uk5 26 20 most most RBS cord-287815-alv30uk5 26 21 notably notably RB cord-287815-alv30uk5 26 22 the the DT cord-287815-alv30uk5 26 23 ordered order VBN cord-287815-alv30uk5 26 24 remodeling remodeling NN cord-287815-alv30uk5 26 25 of of IN cord-287815-alv30uk5 26 26 their -PRON- PRP$ cord-287815-alv30uk5 26 27 N n CD cord-287815-alv30uk5 26 28 - - HYPH cord-287815-alv30uk5 26 29 linked link VBN cord-287815-alv30uk5 26 30 oli oli NNP cord-287815-alv30uk5 26 31 - - HYPH cord-287815-alv30uk5 26 32 gosaccharide gosaccharide NNP cord-287815-alv30uk5 26 33 side side NN cord-287815-alv30uk5 26 34 chains chain NNS cord-287815-alv30uk5 26 35 and and CC cord-287815-alv30uk5 26 36 biosynthesis biosynthesis NN cord-287815-alv30uk5 26 37 of of IN cord-287815-alv30uk5 26 38 O o NN cord-287815-alv30uk5 26 39 - - HYPH cord-287815-alv30uk5 26 40 linked link VBN cord-287815-alv30uk5 26 41 glycans glycan NNS cord-287815-alv30uk5 26 42 . . . cord-287815-alv30uk5 27 1 Given give VBN cord-287815-alv30uk5 27 2 the the DT cord-287815-alv30uk5 27 3 directionality directionality NN cord-287815-alv30uk5 27 4 of of IN cord-287815-alv30uk5 27 5 transport transport NN cord-287815-alv30uk5 27 6 and and CC cord-287815-alv30uk5 27 7 the the DT cord-287815-alv30uk5 27 8 sequential sequential JJ cord-287815-alv30uk5 27 9 nature nature NN cord-287815-alv30uk5 27 10 of of IN cord-287815-alv30uk5 27 11 the the DT cord-287815-alv30uk5 27 12 glycosylation glycosylation NN cord-287815-alv30uk5 27 13 events event NNS cord-287815-alv30uk5 27 14 , , , cord-287815-alv30uk5 27 15 it -PRON- PRP cord-287815-alv30uk5 27 16 is be VBZ cord-287815-alv30uk5 27 17 commonly commonly RB cord-287815-alv30uk5 27 18 thought think VBN cord-287815-alv30uk5 27 19 that that IN cord-287815-alv30uk5 27 20 the the DT cord-287815-alv30uk5 27 21 Golgi Golgi NNP cord-287815-alv30uk5 27 22 consists consist VBZ cord-287815-alv30uk5 27 23 of of IN cord-287815-alv30uk5 27 24 a a DT cord-287815-alv30uk5 27 25 series series NN cord-287815-alv30uk5 27 26 of of IN cord-287815-alv30uk5 27 27 functionally functionally RB cord-287815-alv30uk5 27 28 distinct distinct JJ cord-287815-alv30uk5 27 29 compartmentscorresponding compartmentscorresponding NN cord-287815-alv30uk5 27 30 to to IN cord-287815-alv30uk5 27 31 structurally structurally RB cord-287815-alv30uk5 27 32 distinct distinct JJ cord-287815-alv30uk5 27 33 cisternae cisternae NN cord-287815-alv30uk5 27 34 or or CC cord-287815-alv30uk5 27 35 sets set NNS cord-287815-alv30uk5 27 36 of of IN cord-287815-alv30uk5 27 37 cisternae cisternae NN cord-287815-alv30uk5 27 38 ( ( -LRB- cord-287815-alv30uk5 27 39 Dunphy Dunphy NNP cord-287815-alv30uk5 27 40 et et FW cord-287815-alv30uk5 27 41 al al NNP cord-287815-alv30uk5 27 42 . . NNP cord-287815-alv30uk5 27 43 , , , cord-287815-alv30uk5 27 44 1985 1985 CD cord-287815-alv30uk5 27 45 ; ; : cord-287815-alv30uk5 27 46 Duden Duden NNP cord-287815-alv30uk5 27 47 et et NNP cord-287815-alv30uk5 27 48 al al NNP cord-287815-alv30uk5 27 49 . . NNP cord-287815-alv30uk5 27 50 , , , cord-287815-alv30uk5 27 51 1991 1991 CD cord-287815-alv30uk5 27 52 a a LS cord-287815-alv30uk5 27 53 ) ) -RRB- cord-287815-alv30uk5 27 54 . . . cord-287815-alv30uk5 28 1 Accordingly accordingly RB cord-287815-alv30uk5 28 2 , , , cord-287815-alv30uk5 28 3 enzymes enzyme NNS cord-287815-alv30uk5 28 4 involved involve VBN cord-287815-alv30uk5 28 5 in in IN cord-287815-alv30uk5 28 6 the the DT cord-287815-alv30uk5 28 7 early early JJ cord-287815-alv30uk5 28 8 Golgi Golgi NNP cord-287815-alv30uk5 28 9 events event NNS cord-287815-alv30uk5 28 10 in in IN cord-287815-alv30uk5 28 11 terminal terminal JJ cord-287815-alv30uk5 28 12 N n CD cord-287815-alv30uk5 28 13 - - HYPH cord-287815-alv30uk5 28 14 glycosylation glycosylation NN cord-287815-alv30uk5 28 15 - - , cord-287815-alv30uk5 28 16 such such JJ cord-287815-alv30uk5 28 17 as as IN cord-287815-alv30uk5 28 18 the the DT cord-287815-alv30uk5 28 19 trimming trimming NN cord-287815-alv30uk5 28 20 of of IN cord-287815-alv30uk5 28 21 the the DT cord-287815-alv30uk5 28 22 high high JJ cord-287815-alv30uk5 28 23 mannose mannose NN cord-287815-alv30uk5 28 24 chain chain NN cord-287815-alv30uk5 28 25 to to IN cord-287815-alv30uk5 28 26 its -PRON- PRP$ cord-287815-alv30uk5 28 27 mans mans JJ cord-287815-alv30uk5 28 28 form form NN cord-287815-alv30uk5 28 29 by by IN cord-287815-alv30uk5 28 30 mannosidase mannosidase NNP cord-287815-alv30uk5 28 31 l l NN cord-287815-alv30uk5 28 32 - - : cord-287815-alv30uk5 28 33 have have VBP cord-287815-alv30uk5 28 34 been be VBN cord-287815-alv30uk5 28 35 placed place VBN cord-287815-alv30uk5 28 36 in in IN cord-287815-alv30uk5 28 37 the the DT cord-287815-alv30uk5 28 38 cis cis NNP cord-287815-alv30uk5 28 39 Golgi Golgi NNP cord-287815-alv30uk5 28 40 ( ( -LRB- cord-287815-alv30uk5 28 41 Kornfeld Kornfeld NNP cord-287815-alv30uk5 28 42 and and CC cord-287815-alv30uk5 28 43 Kornfeld Kornfeld NNP cord-287815-alv30uk5 28 44 , , , cord-287815-alv30uk5 28 45 1985 1985 CD cord-287815-alv30uk5 28 46 ; ; : cord-287815-alv30uk5 28 47 Pelham Pelham NNP cord-287815-alv30uk5 28 48 , , , cord-287815-alv30uk5 28 49 1989 1989 CD cord-287815-alv30uk5 28 50 ) ) -RRB- cord-287815-alv30uk5 28 51 . . . cord-287815-alv30uk5 29 1 Enzymes enzyme NNS cord-287815-alv30uk5 29 2 involved involve VBN cord-287815-alv30uk5 29 3 in in IN cord-287815-alv30uk5 29 4 intermediate intermediate JJ cord-287815-alv30uk5 29 5 steps step NNS cord-287815-alv30uk5 29 6 , , , cord-287815-alv30uk5 29 7 such such JJ cord-287815-alv30uk5 29 8 as as IN cord-287815-alv30uk5 29 9 the the DT cord-287815-alv30uk5 29 10 transfer transfer NN cord-287815-alv30uk5 29 11 of of IN cord-287815-alv30uk5 29 12 N N NNP cord-287815-alv30uk5 29 13 - - HYPH cord-287815-alv30uk5 29 14 acetylglucosamine acetylglucosamine NNP cord-287815-alv30uk5 29 15 to to IN cord-287815-alv30uk5 29 16 the the DT cord-287815-alv30uk5 29 17 mans mans JJ cord-287815-alv30uk5 29 18 sugars sugar NNS cord-287815-alv30uk5 29 19 ( ( -LRB- cord-287815-alv30uk5 29 20 GlcNAc glcnac NN cord-287815-alv30uk5 29 21 transferase transferase NN cord-287815-alv30uk5 29 22 I I NNP cord-287815-alv30uk5 29 23 ) ) -RRB- cord-287815-alv30uk5 29 24 , , , cord-287815-alv30uk5 29 25 are be VBP cord-287815-alv30uk5 29 26 thought think VBN cord-287815-alv30uk5 29 27 to to TO cord-287815-alv30uk5 29 28 be be VB cord-287815-alv30uk5 29 29 restricted restrict VBN cord-287815-alv30uk5 29 30 to to IN cord-287815-alv30uk5 29 31 medial medial JJ cord-287815-alv30uk5 29 32 cisternae cisternae NN cord-287815-alv30uk5 29 33 ( ( -LRB- cord-287815-alv30uk5 29 34 Dunphy Dunphy NNP cord-287815-alv30uk5 29 35 et et FW cord-287815-alv30uk5 29 36 al al NNP cord-287815-alv30uk5 29 37 . . NNP cord-287815-alv30uk5 29 38 , , , cord-287815-alv30uk5 29 39 1985 1985 CD cord-287815-alv30uk5 29 40 ) ) -RRB- cord-287815-alv30uk5 29 41 . . . cord-287815-alv30uk5 30 1 Finally finally RB cord-287815-alv30uk5 30 2 , , , cord-287815-alv30uk5 30 3 enzymes enzyme NNS cord-287815-alv30uk5 30 4 that that WDT cord-287815-alv30uk5 30 5 catalyze catalyze VBP cord-287815-alv30uk5 30 6 the the DT cord-287815-alv30uk5 30 7 addition addition NN cord-287815-alv30uk5 30 8 of of IN cord-287815-alv30uk5 30 9 terminal terminal JJ cord-287815-alv30uk5 30 10 galactose galactose NN cord-287815-alv30uk5 30 11 and and CC cord-287815-alv30uk5 30 12 sialic sialic JJ cord-287815-alv30uk5 30 13 acid acid NN cord-287815-alv30uk5 30 14 moieties moiety NNS cord-287815-alv30uk5 30 15 ( ( -LRB- cord-287815-alv30uk5 30 16 such such JJ cord-287815-alv30uk5 30 17 as as IN cord-287815-alv30uk5 30 18 galactosyltransferase galactosyltransferase NNP cord-287815-alv30uk5 30 19 and and CC cord-287815-alv30uk5 30 20 sialyltransferase sialyltransferase NNP cord-287815-alv30uk5 30 21 ) ) -RRB- cord-287815-alv30uk5 30 22 are be VBP cord-287815-alv30uk5 30 23 placed place VBN cord-287815-alv30uk5 30 24 in in IN cord-287815-alv30uk5 30 25 trans trans NNP cord-287815-alv30uk5 30 26 cisternae cisternae NNP cord-287815-alv30uk5 30 27 and/or and/or CC cord-287815-alv30uk5 30 28 the the DT cord-287815-alv30uk5 30 29 TGN TGN NNP cord-287815-alv30uk5 30 30 ( ( -LRB- cord-287815-alv30uk5 30 31 Roth Roth NNP cord-287815-alv30uk5 30 32 and and CC cord-287815-alv30uk5 30 33 Berger Berger NNP cord-287815-alv30uk5 30 34 , , , cord-287815-alv30uk5 30 35 1982 1982 CD cord-287815-alv30uk5 30 36 ; ; : cord-287815-alv30uk5 30 37 Roth Roth NNP cord-287815-alv30uk5 30 38 et et FW cord-287815-alv30uk5 30 39 al al NNP cord-287815-alv30uk5 30 40 . . NNP cord-287815-alv30uk5 30 41 , , , cord-287815-alv30uk5 30 42 1985 1985 CD cord-287815-alv30uk5 30 43 ; ; : cord-287815-alv30uk5 30 44 Griffiths Griffiths NNP cord-287815-alv30uk5 30 45 and and CC cord-287815-alv30uk5 30 46 Simons Simons NNP cord-287815-alv30uk5 30 47 , , , cord-287815-alv30uk5 30 48 1986 1986 CD cord-287815-alv30uk5 30 49 ; ; : cord-287815-alv30uk5 30 50 Duncan Duncan NNP cord-287815-alv30uk5 30 51 and and CC cord-287815-alv30uk5 30 52 Kornfeld Kornfeld NNP cord-287815-alv30uk5 30 53 , , , cord-287815-alv30uk5 30 54 1988 1988 CD cord-287815-alv30uk5 30 55 ; ; : cord-287815-alv30uk5 30 56 Taatjes Taatjes NNP cord-287815-alv30uk5 30 57 et et NNP cord-287815-alv30uk5 30 58 al al NNP cord-287815-alv30uk5 30 59 . . NNP cord-287815-alv30uk5 30 60 , , , cord-287815-alv30uk5 30 61 1988 1988 CD cord-287815-alv30uk5 30 62 ) ) -RRB- cord-287815-alv30uk5 30 63 . . . cord-287815-alv30uk5 31 1 The the DT cord-287815-alv30uk5 31 2 scheme scheme NN cord-287815-alv30uk5 31 3 thus thus RB cord-287815-alv30uk5 31 4 predicts predict VBZ cord-287815-alv30uk5 31 5 that that IN cord-287815-alv30uk5 31 6 a a DT cord-287815-alv30uk5 31 7 series series NN cord-287815-alv30uk5 31 8 of of IN cord-287815-alv30uk5 31 9 sequential sequential JJ cord-287815-alv30uk5 31 10 biochemical biochemical JJ cord-287815-alv30uk5 31 11 reactions reaction NNS cord-287815-alv30uk5 31 12 occurs occur VBZ cord-287815-alv30uk5 31 13 within within IN cord-287815-alv30uk5 31 14 separate separate JJ cord-287815-alv30uk5 31 15 compartments compartment NNS cord-287815-alv30uk5 31 16 , , , cord-287815-alv30uk5 31 17 through through IN cord-287815-alv30uk5 31 18 which which WDT cord-287815-alv30uk5 31 19 glycoprotein glycoprotein NN cord-287815-alv30uk5 31 20 substrates substrate NNS cord-287815-alv30uk5 31 21 pass pass VBP cord-287815-alv30uk5 31 22 as as IN cord-287815-alv30uk5 31 23 if if IN cord-287815-alv30uk5 31 24 on on IN cord-287815-alv30uk5 31 25 an an DT cord-287815-alv30uk5 31 26 assembly assembly NN cord-287815-alv30uk5 31 27 line line NN cord-287815-alv30uk5 31 28 . . . cord-287815-alv30uk5 32 1 A a DT cord-287815-alv30uk5 32 2 consequence consequence NN cord-287815-alv30uk5 32 3 of of IN cord-287815-alv30uk5 32 4 this this DT cord-287815-alv30uk5 32 5 multicompartment multicompartment NN cord-287815-alv30uk5 32 6 arrangement arrangement NN cord-287815-alv30uk5 32 7 is be VBZ cord-287815-alv30uk5 32 8 that that IN cord-287815-alv30uk5 32 9 newly newly RB cord-287815-alv30uk5 32 10 synthesized synthesize VBN cord-287815-alv30uk5 32 11 proteins protein NNS cord-287815-alv30uk5 32 12 must must MD cord-287815-alv30uk5 32 13 be be VB cord-287815-alv30uk5 32 14 transferred transfer VBN cord-287815-alv30uk5 32 15 from from IN cord-287815-alv30uk5 32 16 one one CD cord-287815-alv30uk5 32 17 Golgi Golgi NNP cord-287815-alv30uk5 32 18 compartment compartment NN cord-287815-alv30uk5 32 19 to to IN cord-287815-alv30uk5 32 20 the the DT cord-287815-alv30uk5 32 21 next next JJ cord-287815-alv30uk5 32 22 . . . cord-287815-alv30uk5 33 1 The the DT cord-287815-alv30uk5 33 2 most most RBS cord-287815-alv30uk5 33 3 widely widely RB cord-287815-alv30uk5 33 4 held held JJ cord-287815-alv30uk5 33 5 view view NN cord-287815-alv30uk5 33 6 is be VBZ cord-287815-alv30uk5 33 7 that that IN cord-287815-alv30uk5 33 8 transport transport NN cord-287815-alv30uk5 33 9 vesicles vesicle NNS cord-287815-alv30uk5 33 10 bud bud NN cord-287815-alv30uk5 33 11 from from IN cord-287815-alv30uk5 33 12 the the DT cord-287815-alv30uk5 33 13 dilated dilated JJ cord-287815-alv30uk5 33 14 rims rim NNS cord-287815-alv30uk5 33 15 of of IN cord-287815-alv30uk5 33 16 cisternae cisternae NN cord-287815-alv30uk5 33 17 and and CC cord-287815-alv30uk5 33 18 then then RB cord-287815-alv30uk5 33 19 fuse fuse VB cord-287815-alv30uk5 33 20 with with IN cord-287815-alv30uk5 33 21 the the DT cord-287815-alv30uk5 33 22 next next JJ cord-287815-alv30uk5 33 23 . . . cord-287815-alv30uk5 34 1 Such such JJ cord-287815-alv30uk5 34 2 a a DT cord-287815-alv30uk5 34 3 mechanism mechanism NN cord-287815-alv30uk5 34 4 is be VBZ cord-287815-alv30uk5 34 5 consistent consistent JJ cord-287815-alv30uk5 34 6 with with IN cord-287815-alv30uk5 34 7 the the DT cord-287815-alv30uk5 34 8 existence existence NN cord-287815-alv30uk5 34 9 of of IN cord-287815-alv30uk5 34 10 the the DT cord-287815-alv30uk5 34 11 numerous numerous JJ cord-287815-alv30uk5 34 12 small small JJ cord-287815-alv30uk5 34 13 vesicles vesicle NNS cord-287815-alv30uk5 34 14 found find VBN cord-287815-alv30uk5 34 15 in in IN cord-287815-alv30uk5 34 16 the the DT cord-287815-alv30uk5 34 17 vicinity vicinity NN cord-287815-alv30uk5 34 18 of of IN cord-287815-alv30uk5 34 19 the the DT cord-287815-alv30uk5 34 20 Golgi Golgi NNP cord-287815-alv30uk5 34 21 ( ( -LRB- cord-287815-alv30uk5 34 22 Farquhar Farquhar NNP cord-287815-alv30uk5 34 23 and and CC cord-287815-alv30uk5 34 24 Palade Palade NNP cord-287815-alv30uk5 34 25 , , , cord-287815-alv30uk5 34 26 1981 1981 CD cord-287815-alv30uk5 34 27 ) ) -RRB- cord-287815-alv30uk5 34 28 . . . cord-287815-alv30uk5 35 1 Since since IN cord-287815-alv30uk5 35 2 transport transport NN cord-287815-alv30uk5 35 3 of of IN cord-287815-alv30uk5 35 4 proteins protein NNS cord-287815-alv30uk5 35 5 and and CC cord-287815-alv30uk5 35 6 small small JJ cord-287815-alv30uk5 35 7 molecules molecule NNS cord-287815-alv30uk5 35 8 through through IN cord-287815-alv30uk5 35 9 the the DT cord-287815-alv30uk5 35 10 secretory secretory JJ cord-287815-alv30uk5 35 11 pathway pathway NN cord-287815-alv30uk5 35 12 does do VBZ cord-287815-alv30uk5 35 13 not not RB cord-287815-alv30uk5 35 14 appear appear VB cord-287815-alv30uk5 35 15 to to TO cord-287815-alv30uk5 35 16 require require VB cord-287815-alv30uk5 35 17 any any DT cord-287815-alv30uk5 35 18 identifiable identifiable JJ cord-287815-alv30uk5 35 19 signals signal NNS cord-287815-alv30uk5 35 20 , , , cord-287815-alv30uk5 35 21 it -PRON- PRP cord-287815-alv30uk5 35 22 is be VBZ cord-287815-alv30uk5 35 23 also also RB cord-287815-alv30uk5 35 24 thought think VBN cord-287815-alv30uk5 35 25 that that DT cord-287815-alv30uk5 35 26 transit transit NN cord-287815-alv30uk5 35 27 through through IN cord-287815-alv30uk5 35 28 the the DT cord-287815-alv30uk5 35 29 Golgi Golgi NNP cord-287815-alv30uk5 35 30 occurs occur VBZ cord-287815-alv30uk5 35 31 by by IN cord-287815-alv30uk5 35 32 " " `` cord-287815-alv30uk5 35 33 bulk bulk JJ cord-287815-alv30uk5 35 34 flow flow NN cord-287815-alv30uk5 35 35 " " '' cord-287815-alv30uk5 35 36 ( ( -LRB- cord-287815-alv30uk5 35 37 Pfeffer Pfeffer NNP cord-287815-alv30uk5 35 38 and and CC cord-287815-alv30uk5 35 39 Rothman Rothman NNP cord-287815-alv30uk5 35 40 , , , cord-287815-alv30uk5 35 41 1987 1987 CD cord-287815-alv30uk5 35 42 ) ) -RRB- cord-287815-alv30uk5 35 43 . . . cord-287815-alv30uk5 36 1 In in IN cord-287815-alv30uk5 36 2 other other JJ cord-287815-alv30uk5 36 3 words word NNS cord-287815-alv30uk5 36 4 , , , cord-287815-alv30uk5 36 5 the the DT cord-287815-alv30uk5 36 6 intercisternal intercisternal JJ cord-287815-alv30uk5 36 7 transport transport NN cord-287815-alv30uk5 36 8 vesicles vesicle NNS cord-287815-alv30uk5 36 9 may may MD cord-287815-alv30uk5 36 10 not not RB cord-287815-alv30uk5 36 11 selectively selectively RB cord-287815-alv30uk5 36 12 include include VB cord-287815-alv30uk5 36 13 components component NNS cord-287815-alv30uk5 36 14 intended intend VBN cord-287815-alv30uk5 36 15 for for IN cord-287815-alv30uk5 36 16 transport transport NN cord-287815-alv30uk5 36 17 . . . cord-287815-alv30uk5 37 1 Rather rather RB cord-287815-alv30uk5 37 2 , , , cord-287815-alv30uk5 37 3 resident resident JJ cord-287815-alv30uk5 37 4 proteins protein NNS cord-287815-alv30uk5 37 5 of of IN cord-287815-alv30uk5 37 6 any any DT cord-287815-alv30uk5 37 7 one one CD cord-287815-alv30uk5 37 8 cisterna cisterna NN cord-287815-alv30uk5 37 9 must must MD cord-287815-alv30uk5 37 10 be be VB cord-287815-alv30uk5 37 11 selectively selectively RB cord-287815-alv30uk5 37 12 excluded exclude VBN cord-287815-alv30uk5 37 13 from from IN cord-287815-alv30uk5 37 14 entering enter VBG cord-287815-alv30uk5 37 15 these these DT cord-287815-alv30uk5 37 16 transport transport NN cord-287815-alv30uk5 37 17 vesicles vesicle NNS cord-287815-alv30uk5 37 18 , , , cord-287815-alv30uk5 37 19 most most RBS cord-287815-alv30uk5 37 20 likely likely RB cord-287815-alv30uk5 37 21 reflecting reflect VBG cord-287815-alv30uk5 37 22 the the DT cord-287815-alv30uk5 37 23 selective selective JJ cord-287815-alv30uk5 37 24 retention retention NN cord-287815-alv30uk5 37 25 of of IN cord-287815-alv30uk5 37 26 resident resident JJ cord-287815-alv30uk5 37 27 proteins protein NNS cord-287815-alv30uk5 37 28 in in IN cord-287815-alv30uk5 37 29 their -PRON- PRP$ cord-287815-alv30uk5 37 30 appropriate appropriate JJ cord-287815-alv30uk5 37 31 cisternae cisternae NN cord-287815-alv30uk5 37 32 . . . cord-287815-alv30uk5 38 1 A a DT cord-287815-alv30uk5 38 2 few few JJ cord-287815-alv30uk5 38 3 cellular cellular JJ cord-287815-alv30uk5 38 4 and and CC cord-287815-alv30uk5 38 5 viral viral JJ cord-287815-alv30uk5 38 6 glycoproteins glycoprotein NNS cord-287815-alv30uk5 38 7 are be VBP cord-287815-alv30uk5 38 8 known know VBN cord-287815-alv30uk5 38 9 that that WDT cord-287815-alv30uk5 38 10 appear appear VBP cord-287815-alv30uk5 38 11 to to TO cord-287815-alv30uk5 38 12 have have VB cord-287815-alv30uk5 38 13 such such JJ cord-287815-alv30uk5 38 14 retention retention NN cord-287815-alv30uk5 38 15 signals signal NNS cord-287815-alv30uk5 38 16 , , , cord-287815-alv30uk5 38 17 resulting result VBG cord-287815-alv30uk5 38 18 in in IN cord-287815-alv30uk5 38 19 their -PRON- PRP$ cord-287815-alv30uk5 38 20 accumulation accumulation NN cord-287815-alv30uk5 38 21 in in IN cord-287815-alv30uk5 38 22 the the DT cord-287815-alv30uk5 38 23 Golgi Golgi NNP cord-287815-alv30uk5 38 24 ( ( -LRB- cord-287815-alv30uk5 38 25 Colley Colley NNP cord-287815-alv30uk5 38 26 et et NNP cord-287815-alv30uk5 38 27 al al NNP cord-287815-alv30uk5 38 28 . . NNP cord-287815-alv30uk5 38 29 , , , cord-287815-alv30uk5 38 30 1989 1989 CD cord-287815-alv30uk5 38 31 ; ; : cord-287815-alv30uk5 38 32 Swift Swift NNP cord-287815-alv30uk5 38 33 and and CC cord-287815-alv30uk5 38 34 Machamer Machamer NNP cord-287815-alv30uk5 38 35 , , , cord-287815-alv30uk5 38 36 1991 1991 CD cord-287815-alv30uk5 38 37 ; ; : cord-287815-alv30uk5 38 38 Nilsson Nilsson NNP cord-287815-alv30uk5 38 39 et et NNP cord-287815-alv30uk5 38 40 al al NNP cord-287815-alv30uk5 38 41 . . NNP cord-287815-alv30uk5 38 42 , , , cord-287815-alv30uk5 38 43 1991 1991 CD cord-287815-alv30uk5 38 44 ; ; : cord-287815-alv30uk5 38 45 Munro Munro NNP cord-287815-alv30uk5 38 46 , , , cord-287815-alv30uk5 38 47 1991 1991 CD cord-287815-alv30uk5 38 48 ) ) -RRB- cord-287815-alv30uk5 38 49 . . . cord-287815-alv30uk5 39 1 Finally finally RB cord-287815-alv30uk5 39 2 , , , cord-287815-alv30uk5 39 3 at at IN cord-287815-alv30uk5 39 4 the the DT cord-287815-alv30uk5 39 5 level level NN cord-287815-alv30uk5 39 6 of of IN cord-287815-alv30uk5 39 7 the the DT cord-287815-alv30uk5 39 8 TGN TGN NNP cord-287815-alv30uk5 39 9 , , , cord-287815-alv30uk5 39 10 terminally terminally RB cord-287815-alv30uk5 39 11 glycosylated glycosylated JJ cord-287815-alv30uk5 39 12 proteins protein NNS cord-287815-alv30uk5 39 13 are be VBP cord-287815-alv30uk5 39 14 sorted sort VBN cord-287815-alv30uk5 39 15 to to IN cord-287815-alv30uk5 39 16 their -PRON- PRP$ cord-287815-alv30uk5 39 17 destinations destination NNS cord-287815-alv30uk5 39 18 ( ( -LRB- cord-287815-alv30uk5 39 19 Griffiths Griffiths NNP cord-287815-alv30uk5 39 20 and and CC cord-287815-alv30uk5 39 21 Simons Simons NNP cord-287815-alv30uk5 39 22 , , , cord-287815-alv30uk5 39 23 1986 1986 CD cord-287815-alv30uk5 39 24 ) ) -RRB- cord-287815-alv30uk5 39 25 . . . cord-287815-alv30uk5 40 1 Proteins protein NNS cord-287815-alv30uk5 40 2 intended intend VBN cord-287815-alv30uk5 40 3 for for IN cord-287815-alv30uk5 40 4 transport transport NN cord-287815-alv30uk5 40 5 to to IN cord-287815-alv30uk5 40 6 lysosomes lysosome NNS cord-287815-alv30uk5 40 7 Electron Electron NNP cord-287815-alv30uk5 40 8 micrograph micrograph NN cord-287815-alv30uk5 40 9 is be VBZ cord-287815-alv30uk5 40 10 taken take VBN cord-287815-alv30uk5 40 11 from from IN cord-287815-alv30uk5 40 12 Rambourg Rambourg NNP cord-287815-alv30uk5 40 13 and and CC cord-287815-alv30uk5 40 14 Clermont Clermont NNP cord-287815-alv30uk5 40 15 ( ( -LRB- cord-287815-alv30uk5 40 16 1990 1990 CD cord-287815-alv30uk5 40 17 ) ) -RRB- cord-287815-alv30uk5 40 18 with with IN cord-287815-alv30uk5 40 19 permission permission NN cord-287815-alv30uk5 40 20 . . . cord-287815-alv30uk5 41 1 The the DT cord-287815-alv30uk5 41 2 trans trans JJ cord-287815-alv30uk5 41 3 side side NN cord-287815-alv30uk5 41 4 is be VBZ cord-287815-alv30uk5 41 5 recognizable recognizable JJ cord-287815-alv30uk5 41 6 by by IN cord-287815-alv30uk5 41 7 maturing mature VBG cord-287815-alv30uk5 41 8 ( ( -LRB- cord-287815-alv30uk5 41 9 Pg Pg NNP cord-287815-alv30uk5 41 10 ) ) -RRB- cord-287815-alv30uk5 41 11 and and CC cord-287815-alv30uk5 41 12 mature mature VB cord-287815-alv30uk5 41 13 ( ( -LRB- cord-287815-alv30uk5 41 14 g g NN cord-287815-alv30uk5 41 15 ) ) -RRB- cord-287815-alv30uk5 41 16 secretory secretory NN cord-287815-alv30uk5 41 17 granules granule NNS cord-287815-alv30uk5 41 18 . . . cord-287815-alv30uk5 42 1 The the DT cord-287815-alv30uk5 42 2 discontinuous discontinuous JJ cord-287815-alv30uk5 42 3 profile profile NN cord-287815-alv30uk5 42 4 of of IN cord-287815-alv30uk5 42 5 the the DT cord-287815-alv30uk5 42 6 fenestrated fenestrated JJ cord-287815-alv30uk5 42 7 network network NN cord-287815-alv30uk5 42 8 is be VBZ cord-287815-alv30uk5 42 9 seen see VBN cord-287815-alv30uk5 42 10 on on IN cord-287815-alv30uk5 42 11 the the DT cord-287815-alv30uk5 42 12 cis cis NNP cord-287815-alv30uk5 42 13 side side NN cord-287815-alv30uk5 42 14 ( ( -LRB- cord-287815-alv30uk5 42 15 CE CE NNP cord-287815-alv30uk5 42 16 ) ) -RRB- cord-287815-alv30uk5 42 17 . . . cord-287815-alv30uk5 43 1 Small small JJ cord-287815-alv30uk5 43 2 vesicles vesicle NNS cord-287815-alv30uk5 43 3 are be VBP cord-287815-alv30uk5 43 4 marked mark VBN cord-287815-alv30uk5 43 5 V v NN cord-287815-alv30uk5 43 6 and and CC cord-287815-alv30uk5 43 7 the the DT cord-287815-alv30uk5 43 8 endoplasmic endoplasmic NN cord-287815-alv30uk5 43 9 reticulum reticulum NN cord-287815-alv30uk5 43 10 is be VBZ cord-287815-alv30uk5 43 11 marked mark VBN cord-287815-alv30uk5 43 12 ER er NN cord-287815-alv30uk5 43 13 . . . cord-287815-alv30uk5 44 1 Also also RB cord-287815-alv30uk5 44 2 notice notice VB cord-287815-alv30uk5 44 3 areas area NNS cord-287815-alv30uk5 44 4 where where WRB cord-287815-alv30uk5 44 5 the the DT cord-287815-alv30uk5 44 6 stack stack NN cord-287815-alv30uk5 44 7 is be VBZ cord-287815-alv30uk5 44 8 disrupted disrupt VBN cord-287815-alv30uk5 44 9 by by IN cord-287815-alv30uk5 44 10 discontinuities discontinuity NNS cord-287815-alv30uk5 44 11 ( ( -LRB- cord-287815-alv30uk5 44 12 48,500 48,500 CD cord-287815-alv30uk5 44 13 x x SYM cord-287815-alv30uk5 44 14 ) ) -RRB- cord-287815-alv30uk5 44 15 . . . cord-287815-alv30uk5 45 1 and and CC cord-287815-alv30uk5 45 2 endosomes endosome NNS cord-287815-alv30uk5 45 3 are be VBP cord-287815-alv30uk5 45 4 sequestered sequester VBN cord-287815-alv30uk5 45 5 into into IN cord-287815-alv30uk5 45 6 clathrin clathrin NN cord-287815-alv30uk5 45 7 - - HYPH cord-287815-alv30uk5 45 8 coated coat VBN cord-287815-alv30uk5 45 9 buds bud NNS cord-287815-alv30uk5 45 10 of of IN cord-287815-alv30uk5 45 11 the the DT cord-287815-alv30uk5 45 12 TGN TGN NNP cord-287815-alv30uk5 45 13 , , , cord-287815-alv30uk5 45 14 owing owe VBG cord-287815-alv30uk5 45 15 to to IN cord-287815-alv30uk5 45 16 specific specific JJ cord-287815-alv30uk5 45 17 recognition recognition NN cord-287815-alv30uk5 45 18 determinants determinant NNS cord-287815-alv30uk5 45 19 ( ( -LRB- cord-287815-alv30uk5 45 20 Kornfeld Kornfeld NNP cord-287815-alv30uk5 45 21 and and CC cord-287815-alv30uk5 45 22 Mellman Mellman NNP cord-287815-alv30uk5 45 23 , , , cord-287815-alv30uk5 45 24 1989 1989 CD cord-287815-alv30uk5 45 25 ; ; : cord-287815-alv30uk5 45 26 Pearse Pearse NNP cord-287815-alv30uk5 45 27 and and CC cord-287815-alv30uk5 45 28 Robinson Robinson NNP cord-287815-alv30uk5 45 29 , , , cord-287815-alv30uk5 45 30 1990 1990 CD cord-287815-alv30uk5 45 31 ) ) -RRB- cord-287815-alv30uk5 45 32 . . . cord-287815-alv30uk5 46 1 Proteins protein NNS cord-287815-alv30uk5 46 2 lacking lack VBG cord-287815-alv30uk5 46 3 these these DT cord-287815-alv30uk5 46 4 signals signal NNS cord-287815-alv30uk5 46 5 , , , cord-287815-alv30uk5 46 6 including include VBG cord-287815-alv30uk5 46 7 soluble soluble JJ cord-287815-alv30uk5 46 8 proteins protein NNS cord-287815-alv30uk5 46 9 destined destine VBN cord-287815-alv30uk5 46 10 for for IN cord-287815-alv30uk5 46 11 secretion secretion NN cord-287815-alv30uk5 46 12 , , , cord-287815-alv30uk5 46 13 are be VBP cord-287815-alv30uk5 46 14 by by IN cord-287815-alv30uk5 46 15 default default NN cord-287815-alv30uk5 46 16 packaged package VBN cord-287815-alv30uk5 46 17 into into IN cord-287815-alv30uk5 46 18 transport transport NN cord-287815-alv30uk5 46 19 vesicles vesicle NNS cord-287815-alv30uk5 46 20 of of IN cord-287815-alv30uk5 46 21 the the DT cord-287815-alv30uk5 46 22 constitutive constitutive JJ cord-287815-alv30uk5 46 23 pathway pathway NN cord-287815-alv30uk5 46 24 that that WDT cord-287815-alv30uk5 46 25 are be VBP cord-287815-alv30uk5 46 26 targeted target VBN cord-287815-alv30uk5 46 27 to to IN cord-287815-alv30uk5 46 28 the the DT cord-287815-alv30uk5 46 29 plasma plasma NN cord-287815-alv30uk5 46 30 membrane membrane NN cord-287815-alv30uk5 46 31 . . . cord-287815-alv30uk5 47 1 In in IN cord-287815-alv30uk5 47 2 the the DT cord-287815-alv30uk5 47 3 TGN TGN NNP cord-287815-alv30uk5 47 4 of of IN cord-287815-alv30uk5 47 5 polarized polarized JJ cord-287815-alv30uk5 47 6 or or CC cord-287815-alv30uk5 47 7 secretory secretory JJ cord-287815-alv30uk5 47 8 cells cell NNS cord-287815-alv30uk5 47 9 ( ( -LRB- cord-287815-alv30uk5 47 10 endocrine endocrine JJ cord-287815-alv30uk5 47 11 and and CC cord-287815-alv30uk5 47 12 exocrine exocrine JJ cord-287815-alv30uk5 47 13 secretory secretory NN cord-287815-alv30uk5 47 14 cells cell NNS cord-287815-alv30uk5 47 15 , , , cord-287815-alv30uk5 47 16 epithelial epithelial JJ cord-287815-alv30uk5 47 17 cells cell NNS cord-287815-alv30uk5 47 18 , , , cord-287815-alv30uk5 47 19 and and CC cord-287815-alv30uk5 47 20 neurons neuron NNS cord-287815-alv30uk5 47 21 ) ) -RRB- cord-287815-alv30uk5 47 22 , , , cord-287815-alv30uk5 47 23 other other JJ cord-287815-alv30uk5 47 24 routes route NNS cord-287815-alv30uk5 47 25 of of IN cord-287815-alv30uk5 47 26 exit exit NN cord-287815-alv30uk5 47 27 may may MD cord-287815-alv30uk5 47 28 occur occur VB cord-287815-alv30uk5 47 29 , , , cord-287815-alv30uk5 47 30 leading lead VBG cord-287815-alv30uk5 47 31 to to IN cord-287815-alv30uk5 47 32 inclusion inclusion NN cord-287815-alv30uk5 47 33 either either CC cord-287815-alv30uk5 47 34 within within IN cord-287815-alv30uk5 47 35 storage storage NN cord-287815-alv30uk5 47 36 granules granule NNS cord-287815-alv30uk5 47 37 ( ( -LRB- cord-287815-alv30uk5 47 38 Kelly Kelly NNP cord-287815-alv30uk5 47 39 , , , cord-287815-alv30uk5 47 40 1985 1985 CD cord-287815-alv30uk5 47 41 ; ; : cord-287815-alv30uk5 48 1 Huttner Huttner NNP cord-287815-alv30uk5 48 2 and and CC cord-287815-alv30uk5 48 3 Tooze Tooze NNP cord-287815-alv30uk5 48 4 , , , cord-287815-alv30uk5 48 5 1989 1989 CD cord-287815-alv30uk5 48 6 ) ) -RRB- cord-287815-alv30uk5 48 7 or or CC cord-287815-alv30uk5 48 8 within within IN cord-287815-alv30uk5 48 9 transport transport NN cord-287815-alv30uk5 48 10 vesicles vesicle NNS cord-287815-alv30uk5 48 11 targeted target VBN cord-287815-alv30uk5 48 12 specifically specifically RB cord-287815-alv30uk5 48 13 to to IN cord-287815-alv30uk5 48 14 the the DT cord-287815-alv30uk5 48 15 apical apical JJ cord-287815-alv30uk5 48 16 or or CC cord-287815-alv30uk5 48 17 basolateral basolateral JJ cord-287815-alv30uk5 48 18 plasma plasma NN cord-287815-alv30uk5 48 19 membranes membrane NNS cord-287815-alv30uk5 48 20 ( ( -LRB- cord-287815-alv30uk5 48 21 Bennett Bennett NNP cord-287815-alv30uk5 48 22 et et NNP cord-287815-alv30uk5 48 23 al al NNP cord-287815-alv30uk5 48 24 . . NNP cord-287815-alv30uk5 48 25 , , , cord-287815-alv30uk5 48 26 1988 1988 CD cord-287815-alv30uk5 48 27 ; ; : cord-287815-alv30uk5 48 28 Wandinger Wandinger NNP cord-287815-alv30uk5 48 29 - - HYPH cord-287815-alv30uk5 48 30 Ness Ness NNP cord-287815-alv30uk5 48 31 et et NNP cord-287815-alv30uk5 48 32 al al NNP cord-287815-alv30uk5 48 33 . . NNP cord-287815-alv30uk5 48 34 , , , cord-287815-alv30uk5 48 35 1990 1990 CD cord-287815-alv30uk5 48 36 ) ) -RRB- cord-287815-alv30uk5 48 37 or or CC cord-287815-alv30uk5 48 38 to to IN cord-287815-alv30uk5 48 39 the the DT cord-287815-alv30uk5 48 40 dendritic dendritic JJ cord-287815-alv30uk5 48 41 and and CC cord-287815-alv30uk5 48 42 axonal axonal JJ cord-287815-alv30uk5 48 43 cell cell NN cord-287815-alv30uk5 48 44 surfaces surface NNS cord-287815-alv30uk5 48 45 ( ( -LRB- cord-287815-alv30uk5 48 46 Dotti Dotti NNP cord-287815-alv30uk5 48 47 and and CC cord-287815-alv30uk5 48 48 Simons Simons NNP cord-287815-alv30uk5 48 49 , , , cord-287815-alv30uk5 48 50 1990 1990 CD cord-287815-alv30uk5 48 51 ) ) -RRB- cord-287815-alv30uk5 48 52 . . . cord-287815-alv30uk5 49 1 How how WRB cord-287815-alv30uk5 49 2 Good good JJ cord-287815-alv30uk5 49 3 Is be VBZ cord-287815-alv30uk5 49 4 the the DT cord-287815-alv30uk5 49 5 Evidence evidence NN cord-287815-alv30uk5 49 6 for for IN cord-287815-alv30uk5 49 7 the the DT cord-287815-alv30uk5 49 8 Current current JJ cord-287815-alv30uk5 49 9 View view NN cord-287815-alv30uk5 49 10 of of IN cord-287815-alv30uk5 49 11 the the DT cord-287815-alv30uk5 49 12 Golgi Golgi NNP cord-287815-alv30uk5 49 13 ? ? . cord-287815-alv30uk5 50 1 As as IN cord-287815-alv30uk5 50 2 we -PRON- PRP cord-287815-alv30uk5 50 3 have have VBP cord-287815-alv30uk5 50 4 seen see VBN cord-287815-alv30uk5 50 5 , , , cord-287815-alv30uk5 50 6 there there EX cord-287815-alv30uk5 50 7 are be VBP cord-287815-alv30uk5 50 8 three three CD cord-287815-alv30uk5 50 9 key key JJ cord-287815-alv30uk5 50 10 elements element NNS cord-287815-alv30uk5 50 11 underlying underlie VBG cord-287815-alv30uk5 50 12 our -PRON- PRP$ cord-287815-alv30uk5 50 13 general general JJ cord-287815-alv30uk5 50 14 view view NN cord-287815-alv30uk5 50 15 of of IN cord-287815-alv30uk5 50 16 the the DT cord-287815-alv30uk5 50 17 Golgi Golgi NNP cord-287815-alv30uk5 50 18 : : : cord-287815-alv30uk5 50 19 that that IN cord-287815-alv30uk5 50 20 the the DT cord-287815-alv30uk5 50 21 Golgi Golgi NNP cord-287815-alv30uk5 50 22 consists consist VBZ cord-287815-alv30uk5 50 23 of of IN cord-287815-alv30uk5 50 24 several several JJ cord-287815-alv30uk5 50 25 discrete discrete JJ cord-287815-alv30uk5 50 26 compartments compartment NNS cord-287815-alv30uk5 50 27 ( ( -LRB- cord-287815-alv30uk5 50 28 cis cis NNP cord-287815-alv30uk5 50 29 , , , cord-287815-alv30uk5 50 30 medial medial NNP cord-287815-alv30uk5 50 31 , , , cord-287815-alv30uk5 50 32 trans trans NNP cord-287815-alv30uk5 50 33 , , , cord-287815-alv30uk5 50 34 and and CC cord-287815-alv30uk5 50 35 TGN TGN NNP cord-287815-alv30uk5 50 36 ) ) -RRB- cord-287815-alv30uk5 50 37 corresponding correspond VBG cord-287815-alv30uk5 50 38 to to IN cord-287815-alv30uk5 50 39 individual individual JJ cord-287815-alv30uk5 50 40 or or CC cord-287815-alv30uk5 50 41 groups group NNS cord-287815-alv30uk5 50 42 of of IN cord-287815-alv30uk5 50 43 cisternae cisternae NNP cord-287815-alv30uk5 50 44 ; ; : cord-287815-alv30uk5 50 45 that that DT cord-287815-alv30uk5 50 46 transit transit NN cord-287815-alv30uk5 50 47 between between IN cord-287815-alv30uk5 50 48 these these DT cord-287815-alv30uk5 50 49 compartments compartment NNS cord-287815-alv30uk5 50 50 occurs occur VBZ cord-287815-alv30uk5 50 51 viavesicular viavesicular JJ cord-287815-alv30uk5 50 52 carriers carrier NNS cord-287815-alv30uk5 50 53 ; ; : cord-287815-alv30uk5 50 54 and and CC cord-287815-alv30uk5 50 55 that that IN cord-287815-alv30uk5 50 56 the the DT cord-287815-alv30uk5 50 57 transport transport NN cord-287815-alv30uk5 50 58 process process NN cord-287815-alv30uk5 50 59 is be VBZ cord-287815-alv30uk5 50 60 inherently inherently RB cord-287815-alv30uk5 50 61 nonselective nonselective JJ cord-287815-alv30uk5 50 62 with with IN cord-287815-alv30uk5 50 63 respect respect NN cord-287815-alv30uk5 50 64 to to IN cord-287815-alv30uk5 50 65 the the DT cord-287815-alv30uk5 50 66 passenger passenger NN cord-287815-alv30uk5 50 67 proteins protein NNS cord-287815-alv30uk5 50 68 . . . cord-287815-alv30uk5 51 1 Let let VB cord-287815-alv30uk5 51 2 us -PRON- PRP cord-287815-alv30uk5 51 3 examine examine VB cord-287815-alv30uk5 51 4 the the DT cord-287815-alv30uk5 51 5 strength strength NN cord-287815-alv30uk5 51 6 of of IN cord-287815-alv30uk5 51 7 the the DT cord-287815-alv30uk5 51 8 evidence evidence NN cord-287815-alv30uk5 51 9 in in IN cord-287815-alv30uk5 51 10 favor favor NN cord-287815-alv30uk5 51 11 of of IN cord-287815-alv30uk5 51 12 each each DT cord-287815-alv30uk5 51 13 of of IN cord-287815-alv30uk5 51 14 these these DT cord-287815-alv30uk5 51 15 propositions proposition NNS cord-287815-alv30uk5 51 16 and and CC cord-287815-alv30uk5 51 17 interpret interpret VB cord-287815-alv30uk5 51 18 the the DT cord-287815-alv30uk5 51 19 data datum NNS cord-287815-alv30uk5 51 20 accordingly accordingly RB cord-287815-alv30uk5 51 21 . . . cord-287815-alv30uk5 52 1 Are be VBP cord-287815-alv30uk5 52 2 There there EX cord-287815-alv30uk5 52 3 ? ? . cord-287815-alv30uk5 53 1 Although although IN cord-287815-alv30uk5 53 2 originally originally RB cord-287815-alv30uk5 53 3 thought think VBN cord-287815-alv30uk5 53 4 to to TO cord-287815-alv30uk5 53 5 be be VB cord-287815-alv30uk5 53 6 a a DT cord-287815-alv30uk5 53 7 " " `` cord-287815-alv30uk5 53 8 fixation fixation NN cord-287815-alv30uk5 53 9 artifact artifact NN cord-287815-alv30uk5 53 10 , , , cord-287815-alv30uk5 53 11 " " '' cord-287815-alv30uk5 53 12 the the DT cord-287815-alv30uk5 53 13 basic basic JJ cord-287815-alv30uk5 53 14 cisternal cisternal JJ cord-287815-alv30uk5 53 15 organization organization NN cord-287815-alv30uk5 53 16 of of IN cord-287815-alv30uk5 53 17 the the DT cord-287815-alv30uk5 53 18 Golgi Golgi NNP cord-287815-alv30uk5 53 19 complex complex NN cord-287815-alv30uk5 53 20 is be VBZ cord-287815-alv30uk5 53 21 now now RB cord-287815-alv30uk5 53 22 accepted accept VBN cord-287815-alv30uk5 53 23 as as IN cord-287815-alv30uk5 53 24 a a DT cord-287815-alv30uk5 53 25 certainty certainty NN cord-287815-alv30uk5 53 26 . . . cord-287815-alv30uk5 54 1 Similarly similarly RB cord-287815-alv30uk5 54 2 , , , cord-287815-alv30uk5 54 3 the the DT cord-287815-alv30uk5 54 4 cis cis NNP cord-287815-alv30uk5 54 5 to to IN cord-287815-alv30uk5 54 6 transdirectionality transdirectionality NN cord-287815-alv30uk5 54 7 of of IN cord-287815-alv30uk5 54 8 transport transport NN cord-287815-alv30uk5 54 9 is be VBZ cord-287815-alv30uk5 54 10 quite quite RB cord-287815-alv30uk5 54 11 clear clear JJ cord-287815-alv30uk5 54 12 from from IN cord-287815-alv30uk5 54 13 early early JJ cord-287815-alv30uk5 54 14 morphological morphological JJ cord-287815-alv30uk5 54 15 and and CC cord-287815-alv30uk5 54 16 autoradiographic autoradiographic JJ cord-287815-alv30uk5 54 17 analysis analysis NN cord-287815-alv30uk5 54 18 in in IN cord-287815-alv30uk5 54 19 exocrine exocrine JJ cord-287815-alv30uk5 54 20 cells cell NNS cord-287815-alv30uk5 54 21 where where WRB cord-287815-alv30uk5 54 22 the the DT cord-287815-alv30uk5 54 23 sidedness sidedness NN cord-287815-alv30uk5 54 24 of of IN cord-287815-alv30uk5 54 25 the the DT cord-287815-alv30uk5 54 26 Golgi Golgi NNP cord-287815-alv30uk5 54 27 is be VBZ cord-287815-alv30uk5 54 28 readily readily RB cord-287815-alv30uk5 54 29 identifiable identifiable JJ cord-287815-alv30uk5 54 30 ( ( -LRB- cord-287815-alv30uk5 54 31 Farquhar Farquhar NNP cord-287815-alv30uk5 54 32 and and CC cord-287815-alv30uk5 54 33 Palade Palade NNP cord-287815-alv30uk5 54 34 , , , cord-287815-alv30uk5 54 35 1981 1981 CD cord-287815-alv30uk5 54 36 ) ) -RRB- cord-287815-alv30uk5 54 37 as as RB cord-287815-alv30uk5 54 38 well well RB cord-287815-alv30uk5 54 39 as as IN cord-287815-alv30uk5 54 40 from from IN cord-287815-alv30uk5 54 41 immunoelectron immunoelectron NNP cord-287815-alv30uk5 54 42 microscopy microscopy NNP cord-287815-alv30uk5 54 43 studies study NNS cord-287815-alv30uk5 54 44 using use VBG cord-287815-alv30uk5 54 45 viral viral JJ cord-287815-alv30uk5 54 46 glycoproteins glycoprotein NNS cord-287815-alv30uk5 54 47 as as IN cord-287815-alv30uk5 54 48 markers marker NNS cord-287815-alv30uk5 54 49 ( ( -LRB- cord-287815-alv30uk5 54 50 Bergmann Bergmann NNP cord-287815-alv30uk5 54 51 and and CC cord-287815-alv30uk5 54 52 Singer Singer NNP cord-287815-alv30uk5 54 53 , , , cord-287815-alv30uk5 54 54 1983 1983 CD cord-287815-alv30uk5 54 55 ) ) -RRB- cord-287815-alv30uk5 54 56 . . . cord-287815-alv30uk5 55 1 What what WP cord-287815-alv30uk5 55 2 is be VBZ cord-287815-alv30uk5 55 3 less less JJR cord-287815-alv30uk5 55 4 than than IN cord-287815-alv30uk5 55 5 clear clear JJ cord-287815-alv30uk5 55 6 , , , cord-287815-alv30uk5 55 7 however however RB cord-287815-alv30uk5 55 8 , , , cord-287815-alv30uk5 55 9 is be VBZ cord-287815-alv30uk5 55 10 the the DT cord-287815-alv30uk5 55 11 extent extent NN cord-287815-alv30uk5 55 12 to to TO cord-287815-alv30uk5 55 13 which which WDT cord-287815-alv30uk5 55 14 the the DT cord-287815-alv30uk5 55 15 Golgi Golgi NNP cord-287815-alv30uk5 55 16 is be VBZ cord-287815-alv30uk5 55 17 divided divide VBN cord-287815-alv30uk5 55 18 into into IN cord-287815-alv30uk5 55 19 distinct distinct JJ cord-287815-alv30uk5 55 20 compartments compartment NNS cord-287815-alv30uk5 55 21 . . . cord-287815-alv30uk5 56 1 As as IN cord-287815-alv30uk5 56 2 mentioned mention VBN cord-287815-alv30uk5 56 3 earlier early RBR cord-287815-alv30uk5 56 4 , , , cord-287815-alv30uk5 56 5 some some DT cord-287815-alv30uk5 56 6 of of IN cord-287815-alv30uk5 56 7 the the DT cord-287815-alv30uk5 56 8 enzymes enzyme NNS cord-287815-alv30uk5 56 9 involved involve VBN cord-287815-alv30uk5 56 10 in in IN cord-287815-alv30uk5 56 11 early early JJ cord-287815-alv30uk5 56 12 , , , cord-287815-alv30uk5 56 13 intermediate intermediate JJ cord-287815-alv30uk5 56 14 , , , cord-287815-alv30uk5 56 15 and and CC cord-287815-alv30uk5 56 16 late late JJ cord-287815-alv30uk5 56 17 steps step NNS cord-287815-alv30uk5 56 18 in in IN cord-287815-alv30uk5 56 19 the the DT cord-287815-alv30uk5 56 20 terminal terminal JJ cord-287815-alv30uk5 56 21 glycosylation glycosylation NN cord-287815-alv30uk5 56 22 of of IN cord-287815-alv30uk5 56 23 N n NN cord-287815-alv30uk5 56 24 - - HYPH cord-287815-alv30uk5 56 25 linked link VBN cord-287815-alv30uk5 56 26 sugar sugar NN cord-287815-alv30uk5 56 27 chains chain NNS cord-287815-alv30uk5 56 28 have have VBP cord-287815-alv30uk5 56 29 been be VBN cord-287815-alv30uk5 56 30 localized localize VBN cord-287815-alv30uk5 56 31 to to IN cord-287815-alv30uk5 56 32 one one CD cord-287815-alv30uk5 56 33 to to TO cord-287815-alv30uk5 56 34 three three CD cord-287815-alv30uk5 56 35 individual individual JJ cord-287815-alv30uk5 56 36 cisternae cisternae NN cord-287815-alv30uk5 56 37 by by IN cord-287815-alv30uk5 56 38 electron electron NN cord-287815-alv30uk5 56 39 microscopy microscopy NNS cord-287815-alv30uk5 56 40 using use VBG cord-287815-alv30uk5 56 41 immunoperoxidase immunoperoxidase NNP cord-287815-alv30uk5 56 42 or or CC cord-287815-alv30uk5 56 43 immunogold immunogold NNP cord-287815-alv30uk5 56 44 cytochemistry cytochemistry NNP cord-287815-alv30uk5 56 45 ( ( -LRB- cord-287815-alv30uk5 56 46 Roth Roth NNP cord-287815-alv30uk5 56 47 and and CC cord-287815-alv30uk5 56 48 Berger Berger NNP cord-287815-alv30uk5 56 49 , , , cord-287815-alv30uk5 56 50 1982 1982 CD cord-287815-alv30uk5 56 51 ; ; : cord-287815-alv30uk5 56 52 Slot Slot NNP cord-287815-alv30uk5 56 53 and and CC cord-287815-alv30uk5 56 54 Geuze Geuze NNP cord-287815-alv30uk5 56 55 , , , cord-287815-alv30uk5 56 56 1983 1983 CD cord-287815-alv30uk5 56 57 ; ; : cord-287815-alv30uk5 56 58 Dunphy Dunphy NNP cord-287815-alv30uk5 56 59 et et NNP cord-287815-alv30uk5 56 60 al al NNP cord-287815-alv30uk5 56 61 . . . cord-287815-alv30uk5 57 1 , , , cord-287815-alv30uk5 57 2 1985 1985 CD cord-287815-alv30uk5 57 3 ; ; : cord-287815-alv30uk5 57 4 Roth Roth NNP cord-287815-alv30uk5 57 5 et et FW cord-287815-alv30uk5 57 6 al al NNP cord-287815-alv30uk5 57 7 . . NNP cord-287815-alv30uk5 57 8 , , , cord-287815-alv30uk5 57 9 1985 1985 CD cord-287815-alv30uk5 57 10 ) ) -RRB- cord-287815-alv30uk5 57 11 . . . cord-287815-alv30uk5 58 1 However however RB cord-287815-alv30uk5 58 2 , , , cord-287815-alv30uk5 58 3 a a DT cord-287815-alv30uk5 58 4 definitive definitive JJ cord-287815-alv30uk5 58 5 demonstration demonstration NN cord-287815-alv30uk5 58 6 that that WDT cord-287815-alv30uk5 58 7 these these DT cord-287815-alv30uk5 58 8 enzymes enzyme NNS cord-287815-alv30uk5 58 9 exist exist VBP cord-287815-alv30uk5 58 10 in in IN cord-287815-alv30uk5 58 11 separate separate JJ cord-287815-alv30uk5 58 12 cisternae cisternae NN cord-287815-alv30uk5 58 13 can can MD cord-287815-alv30uk5 58 14 only only RB cord-287815-alv30uk5 58 15 be be VB cord-287815-alv30uk5 58 16 provided provide VBN cord-287815-alv30uk5 58 17 by by IN cord-287815-alv30uk5 58 18 visualizing visualize VBG cord-287815-alv30uk5 58 19 two two CD cord-287815-alv30uk5 58 20 or or CC cord-287815-alv30uk5 58 21 more more JJR cord-287815-alv30uk5 58 22 enzymes enzyme NNS cord-287815-alv30uk5 58 23 simultaneously simultaneously RB cord-287815-alv30uk5 58 24 . . . cord-287815-alv30uk5 59 1 The the DT cord-287815-alv30uk5 59 2 Golgi Golgi NNP cord-287815-alv30uk5 59 3 complex complex NN cord-287815-alv30uk5 59 4 in in IN cord-287815-alv30uk5 59 5 the the DT cord-287815-alv30uk5 59 6 cell cell NN cord-287815-alv30uk5 59 7 is be VBZ cord-287815-alv30uk5 59 8 not not RB cord-287815-alv30uk5 59 9 the the DT cord-287815-alv30uk5 59 10 idealized idealized JJ cord-287815-alv30uk5 59 11 stack stack NN cord-287815-alv30uk5 59 12 that that IN cord-287815-alv30uk5 59 13 we -PRON- PRP cord-287815-alv30uk5 59 14 are be VBP cord-287815-alv30uk5 59 15 accustomed accustomed JJ cord-287815-alv30uk5 59 16 to to TO cord-287815-alv30uk5 59 17 recognize recognize VB cord-287815-alv30uk5 59 18 in in IN cord-287815-alv30uk5 59 19 diagrams diagram NNS cord-287815-alv30uk5 59 20 , , , cord-287815-alv30uk5 59 21 but but CC cord-287815-alv30uk5 59 22 it -PRON- PRP cord-287815-alv30uk5 59 23 may may MD cord-287815-alv30uk5 59 24 be be VB cord-287815-alv30uk5 59 25 subject subject JJ cord-287815-alv30uk5 59 26 to to IN cord-287815-alv30uk5 59 27 twists twist NNS cord-287815-alv30uk5 59 28 that that WDT cord-287815-alv30uk5 59 29 make make VBP cord-287815-alv30uk5 59 30 individual individual JJ cord-287815-alv30uk5 59 31 sections section NNS cord-287815-alv30uk5 59 32 difficult difficult JJ cord-287815-alv30uk5 59 33 to to TO cord-287815-alv30uk5 59 34 interpret interpret VB cord-287815-alv30uk5 59 35 . . . cord-287815-alv30uk5 60 1 To to IN cord-287815-alv30uk5 60 2 date date NN cord-287815-alv30uk5 60 3 , , , cord-287815-alv30uk5 60 4 simultaneous simultaneous JJ cord-287815-alv30uk5 60 5 localization localization NN cord-287815-alv30uk5 60 6 of of IN cord-287815-alv30uk5 60 7 two two CD cord-287815-alv30uk5 60 8 or or CC cord-287815-alv30uk5 60 9 more more JJR cord-287815-alv30uk5 60 10 enzymes enzyme NNS cord-287815-alv30uk5 60 11 has have VBZ cord-287815-alv30uk5 60 12 not not RB cord-287815-alv30uk5 60 13 been be VBN cord-287815-alv30uk5 60 14 accomplished accomplish VBN cord-287815-alv30uk5 60 15 . . . cord-287815-alv30uk5 61 1 In in IN cord-287815-alv30uk5 61 2 addition addition NN cord-287815-alv30uk5 61 3 , , , cord-287815-alv30uk5 61 4 the the DT cord-287815-alv30uk5 61 5 localization localization NN cord-287815-alv30uk5 61 6 of of IN cord-287815-alv30uk5 61 7 key key JJ cord-287815-alv30uk5 61 8 enzymes enzyme NNS cord-287815-alv30uk5 61 9 such such JJ cord-287815-alv30uk5 61 10 as as IN cord-287815-alv30uk5 61 11 mannosidase mannosidase NN cord-287815-alv30uk5 61 12 I -PRON- PRP cord-287815-alv30uk5 61 13 remains remain VBZ cord-287815-alv30uk5 61 14 to to TO cord-287815-alv30uk5 61 15 be be VB cord-287815-alv30uk5 61 16 established establish VBN cord-287815-alv30uk5 61 17 ; ; : cord-287815-alv30uk5 61 18 this this DT cord-287815-alv30uk5 61 19 is be VBZ cord-287815-alv30uk5 61 20 a a DT cord-287815-alv30uk5 61 21 critical critical JJ cord-287815-alv30uk5 61 22 unknown unknown NN cord-287815-alv30uk5 61 23 , , , cord-287815-alv30uk5 61 24 since since IN cord-287815-alv30uk5 61 25 mannosidase mannosidase NN cord-287815-alv30uk5 61 26 I -PRON- PRP cord-287815-alv30uk5 61 27 is be VBZ cord-287815-alv30uk5 61 28 thought think VBN cord-287815-alv30uk5 61 29 to to TO cord-287815-alv30uk5 61 30 be be VB cord-287815-alv30uk5 61 31 the the DT cord-287815-alv30uk5 61 32 first first JJ cord-287815-alv30uk5 61 33 glycosidase glycosidase NN cord-287815-alv30uk5 61 34 to to TO cord-287815-alv30uk5 61 35 modify modify VB cord-287815-alv30uk5 61 36 N n CD cord-287815-alv30uk5 61 37 - - HYPH cord-287815-alv30uk5 61 38 linked link VBN cord-287815-alv30uk5 61 39 oligosaccharides oligosaccharide NNS cord-287815-alv30uk5 61 40 upon upon IN cord-287815-alv30uk5 61 41 their -PRON- PRP$ cord-287815-alv30uk5 61 42 arrival arrival NN cord-287815-alv30uk5 61 43 in in IN cord-287815-alv30uk5 61 44 the the DT cord-287815-alv30uk5 61 45 Golgi Golgi NNP cord-287815-alv30uk5 61 46 . . . cord-287815-alv30uk5 62 1 A a DT cord-287815-alv30uk5 62 2 further further JJ cord-287815-alv30uk5 62 3 complication complication NN cord-287815-alv30uk5 62 4 is be VBZ cord-287815-alv30uk5 62 5 introduced introduce VBN cord-287815-alv30uk5 62 6 by by IN cord-287815-alv30uk5 62 7 the the DT cord-287815-alv30uk5 62 8 fact fact NN cord-287815-alv30uk5 62 9 that that IN cord-287815-alv30uk5 62 10 there there EX cord-287815-alv30uk5 62 11 appears appear VBZ cord-287815-alv30uk5 62 12 to to TO cord-287815-alv30uk5 62 13 be be VB cord-287815-alv30uk5 62 14 considerable considerable JJ cord-287815-alv30uk5 62 15 variation variation NN cord-287815-alv30uk5 62 16 between between IN cord-287815-alv30uk5 62 17 cell cell NN cord-287815-alv30uk5 62 18 types type NNS cord-287815-alv30uk5 62 19 . . . cord-287815-alv30uk5 63 1 For for IN cord-287815-alv30uk5 63 2 example example NN cord-287815-alv30uk5 63 3 , , , cord-287815-alv30uk5 63 4 in in IN cord-287815-alv30uk5 63 5 goblet goblet NN cord-287815-alv30uk5 63 6 cells cell NNS cord-287815-alv30uk5 63 7 of of IN cord-287815-alv30uk5 63 8 the the DT cord-287815-alv30uk5 63 9 intestine intestine NN cord-287815-alv30uk5 63 10 , , , cord-287815-alv30uk5 63 11 galactose galactose NN cord-287815-alv30uk5 63 12 a2,6-sialyltransferase a2,6-sialyltransferase . cord-287815-alv30uk5 63 13 ( ( -LRB- cord-287815-alv30uk5 63 14 the the DT cord-287815-alv30uk5 63 15 enzyme enzyme NN cord-287815-alv30uk5 63 16 responsible responsible JJ cord-287815-alv30uk5 63 17 for for IN cord-287815-alv30uk5 63 18 adding add VBG cord-287815-alv30uk5 63 19 l.erminal l.erminal DT cord-287815-alv30uk5 63 20 sialic sialic JJ cord-287815-alv30uk5 63 21 acid acid NN cord-287815-alv30uk5 63 22 residues residue NNS cord-287815-alv30uk5 63 23 to to IN cord-287815-alv30uk5 63 24 N n NN cord-287815-alv30uk5 63 25 - - HYPH cord-287815-alv30uk5 63 26 linked link VBN cord-287815-alv30uk5 63 27 sugars sugar NNS cord-287815-alv30uk5 63 28 ) ) -RRB- cord-287815-alv30uk5 63 29 has have VBZ cord-287815-alv30uk5 63 30 been be VBN cord-287815-alv30uk5 63 31 localized localize VBN cord-287815-alv30uk5 63 32 to to IN cord-287815-alv30uk5 63 33 trans trans NNP cord-287815-alv30uk5 63 34 cisternae cisternae NNP cord-287815-alv30uk5 63 35 , , , cord-287815-alv30uk5 63 36 as as IN cord-287815-alv30uk5 63 37 is be VBZ cord-287815-alv30uk5 63 38 the the DT cord-287815-alv30uk5 63 39 case case NN cord-287815-alv30uk5 63 40 in in IN cord-287815-alv30uk5 63 41 hepatocytes hepatocyte NNS cord-287815-alv30uk5 63 42 . . . cord-287815-alv30uk5 64 1 In in IN cord-287815-alv30uk5 64 2 neighboring neighboring JJ cord-287815-alv30uk5 64 3 absorptive absorptive JJ cord-287815-alv30uk5 64 4 cells cell NNS cord-287815-alv30uk5 64 5 of of IN cord-287815-alv30uk5 64 6 the the DT cord-287815-alv30uk5 64 7 gut gut NN cord-287815-alv30uk5 64 8 , , , cord-287815-alv30uk5 64 9 however however RB cord-287815-alv30uk5 64 10 , , , cord-287815-alv30uk5 64 11 almost almost RB cord-287815-alv30uk5 64 12 lhe lhe DT cord-287815-alv30uk5 64 13 entire entire JJ cord-287815-alv30uk5 64 14 Golgi Golgi NNP cord-287815-alv30uk5 64 15 stack stack NN cord-287815-alv30uk5 64 16 is be VBZ cord-287815-alv30uk5 64 17 labeled label VBN cord-287815-alv30uk5 64 18 ( ( -LRB- cord-287815-alv30uk5 64 19 except except IN cord-287815-alv30uk5 64 20 forthe forthe DT cord-287815-alv30uk5 64 21 cis cis NNP cord-287815-alv30uk5 64 22 cisterna cisterna NNP cord-287815-alv30uk5 64 23 ) ) -RRB- cord-287815-alv30uk5 65 1 ( ( -LRB- cord-287815-alv30uk5 65 2 Roth Roth NNP cord-287815-alv30uk5 65 3 et et FW cord-287815-alv30uk5 65 4 al al NNP cord-287815-alv30uk5 65 5 . . NNP cord-287815-alv30uk5 65 6 , , , cord-287815-alv30uk5 65 7 1986 1986 CD cord-287815-alv30uk5 65 8 ) ) -RRB- cord-287815-alv30uk5 65 9 . . . cord-287815-alv30uk5 66 1 It -PRON- PRP cord-287815-alv30uk5 66 2 has have VBZ cord-287815-alv30uk5 66 3 also also RB cord-287815-alv30uk5 66 4 recently recently RB cord-287815-alv30uk5 66 5 become become VBN cord-287815-alv30uk5 66 6 clear clear JJ cord-287815-alv30uk5 66 7 that that IN cord-287815-alv30uk5 66 8 Golgi Golgi NNP cord-287815-alv30uk5 66 9 glycosyltransferases glycosyltransferase NNS cord-287815-alv30uk5 66 10 may may MD cord-287815-alv30uk5 66 11 have have VB cord-287815-alv30uk5 66 12 multiple multiple JJ cord-287815-alv30uk5 66 13 isoforms isoform NNS cord-287815-alv30uk5 66 14 with with IN cord-287815-alv30uk5 66 15 either either CC cord-287815-alv30uk5 66 16 Golgi Golgi NNP cord-287815-alv30uk5 66 17 or or CC cord-287815-alv30uk5 66 18 plasma plasma NN cord-287815-alv30uk5 66 19 membrane membrane NN cord-287815-alv30uk5 66 20 distributions distribution NNS cord-287815-alv30uk5 66 21 . . . cord-287815-alv30uk5 67 1 For for IN cord-287815-alv30uk5 67 2 example example NN cord-287815-alv30uk5 67 3 , , , cord-287815-alv30uk5 67 4 two two CD cord-287815-alv30uk5 67 5 isoforms isoform NNS cord-287815-alv30uk5 67 6 of of IN cord-287815-alv30uk5 67 7 81 81 CD cord-287815-alv30uk5 67 8 - - SYM cord-287815-alv30uk5 67 9 4 4 CD cord-287815-alv30uk5 67 10 galactosyltransferase galactosyltransferase NN cord-287815-alv30uk5 67 11 have have VBP cord-287815-alv30uk5 67 12 been be VBN cord-287815-alv30uk5 67 13 found find VBN cord-287815-alv30uk5 67 14 that that IN cord-287815-alv30uk5 67 15 differ differ VBP cord-287815-alv30uk5 67 16 by by IN cord-287815-alv30uk5 67 17 a a DT cord-287815-alv30uk5 67 18 13 13 CD cord-287815-alv30uk5 67 19 amino amino NN cord-287815-alv30uk5 67 20 acid acid NN cord-287815-alv30uk5 67 21 addition addition NN cord-287815-alv30uk5 67 22 at at IN cord-287815-alv30uk5 67 23 the the DT cord-287815-alv30uk5 67 24 cytoplasmic cytoplasmic JJ cord-287815-alv30uk5 67 25 N n CD cord-287815-alv30uk5 67 26 - - HYPH cord-287815-alv30uk5 67 27 terminus terminus NN cord-287815-alv30uk5 68 1 ( ( -LRB- cord-287815-alv30uk5 68 2 Lopez Lopez NNP cord-287815-alv30uk5 68 3 et et NNP cord-287815-alv30uk5 68 4 al al NNP cord-287815-alv30uk5 68 5 . . NNP cord-287815-alv30uk5 68 6 , , , cord-287815-alv30uk5 68 7 1991 1991 CD cord-287815-alv30uk5 68 8 ) ) -RRB- cord-287815-alv30uk5 68 9 . . . cord-287815-alv30uk5 69 1 The the DT cord-287815-alv30uk5 69 2 short short JJ cord-287815-alv30uk5 69 3 galactosyltransferase galactosyltransferase NN cord-287815-alv30uk5 69 4 remains remain VBZ cord-287815-alv30uk5 69 5 in in IN cord-287815-alv30uk5 69 6 the the DT cord-287815-alv30uk5 69 7 Golgi Golgi NNP cord-287815-alv30uk5 69 8 , , , cord-287815-alv30uk5 69 9 while while IN cord-287815-alv30uk5 69 10 the the DT cord-287815-alv30uk5 69 11 long long JJ cord-287815-alv30uk5 69 12 form form NN cord-287815-alv30uk5 69 13 is be VBZ cord-287815-alv30uk5 69 14 directed direct VBN cord-287815-alv30uk5 69 15 to to IN cord-287815-alv30uk5 69 16 the the DT cord-287815-alv30uk5 69 17 plasma plasma NN cord-287815-alv30uk5 69 18 membrane membrane NN cord-287815-alv30uk5 69 19 . . . cord-287815-alv30uk5 70 1 Cell cell NN cord-287815-alv30uk5 70 2 fractionation fractionation NN cord-287815-alv30uk5 70 3 experiments experiment NNS cord-287815-alv30uk5 70 4 have have VBP cord-287815-alv30uk5 70 5 also also RB cord-287815-alv30uk5 70 6 contributed contribute VBN cord-287815-alv30uk5 70 7 to to IN cord-287815-alv30uk5 70 8 our -PRON- PRP$ cord-287815-alv30uk5 70 9 view view NN cord-287815-alv30uk5 70 10 of of IN cord-287815-alv30uk5 70 11 the the DT cord-287815-alv30uk5 70 12 Golgi Golgi NNP cord-287815-alv30uk5 70 13 as as IN cord-287815-alv30uk5 70 14 a a DT cord-287815-alv30uk5 70 15 multicompartment multicompartment NN cord-287815-alv30uk5 70 16 organelle organelle NN cord-287815-alv30uk5 70 17 , , , cord-287815-alv30uk5 70 18 since since IN cord-287815-alv30uk5 70 19 it -PRON- PRP cord-287815-alv30uk5 70 20 has have VBZ cord-287815-alv30uk5 70 21 been be VBN cord-287815-alv30uk5 70 22 possible possible JJ cord-287815-alv30uk5 70 23 to to TO cord-287815-alv30uk5 70 24 partly partly RB cord-287815-alv30uk5 70 25 separate separate JJ cord-287815-alv30uk5 70 26 membranes membrane NNS cord-287815-alv30uk5 70 27 containing contain VBG cord-287815-alv30uk5 70 28 several several JJ cord-287815-alv30uk5 70 29 of of IN cord-287815-alv30uk5 70 30 the the DT cord-287815-alv30uk5 70 31 enzymes enzyme NNS cord-287815-alv30uk5 70 32 involved involve VBN cord-287815-alv30uk5 70 33 in in IN cord-287815-alv30uk5 70 34 Golgi Golgi NNP cord-287815-alv30uk5 70 35 processing processing NN cord-287815-alv30uk5 70 36 events event NNS cord-287815-alv30uk5 70 37 ( ( -LRB- cord-287815-alv30uk5 70 38 Goldberg Goldberg NNP cord-287815-alv30uk5 70 39 and and CC cord-287815-alv30uk5 70 40 Kornfeld Kornfeld NNP cord-287815-alv30uk5 70 41 , , , cord-287815-alv30uk5 70 42 1983 1983 CD cord-287815-alv30uk5 70 43 ; ; : cord-287815-alv30uk5 70 44 Dunphy Dunphy NNP cord-287815-alv30uk5 70 45 and and CC cord-287815-alv30uk5 70 46 Hothman Hothman NNP cord-287815-alv30uk5 70 47 , , , cord-287815-alv30uk5 70 48 1983 1983 CD cord-287815-alv30uk5 70 49 ) ) -RRB- cord-287815-alv30uk5 70 50 . . . cord-287815-alv30uk5 71 1 However however RB cord-287815-alv30uk5 71 2 , , , cord-287815-alv30uk5 71 3 interpretation interpretation NN cord-287815-alv30uk5 71 4 of of IN cord-287815-alv30uk5 71 5 these these DT cord-287815-alv30uk5 71 6 data datum NNS cord-287815-alv30uk5 71 7 is be VBZ cord-287815-alv30uk5 71 8 limited limit VBN cord-287815-alv30uk5 71 9 on on IN cord-287815-alv30uk5 71 10 two two CD cord-287815-alv30uk5 71 11 accounts account NNS cord-287815-alv30uk5 71 12 . . . cord-287815-alv30uk5 72 1 First first RB cord-287815-alv30uk5 72 2 , , , cord-287815-alv30uk5 72 3 in in IN cord-287815-alv30uk5 72 4 the the DT cord-287815-alv30uk5 72 5 absence absence NN cord-287815-alv30uk5 72 6 of of IN cord-287815-alv30uk5 72 7 definitive definitive JJ cord-287815-alv30uk5 72 8 immunocytochemical immunocytochemical JJ cord-287815-alv30uk5 72 9 localization localization NN cord-287815-alv30uk5 72 10 , , , cord-287815-alv30uk5 72 11 it -PRON- PRP cord-287815-alv30uk5 72 12 is be VBZ cord-287815-alv30uk5 72 13 impossible impossible JJ cord-287815-alv30uk5 72 14 to to TO cord-287815-alv30uk5 72 15 know know VB cord-287815-alv30uk5 72 16 whether whether IN cord-287815-alv30uk5 72 17 the the DT cord-287815-alv30uk5 72 18 different different JJ cord-287815-alv30uk5 72 19 fractions fraction NNS cord-287815-alv30uk5 72 20 correspond correspond VBP cord-287815-alv30uk5 72 21 to to IN cord-287815-alv30uk5 72 22 different different JJ cord-287815-alv30uk5 72 23 sets set NNS cord-287815-alv30uk5 72 24 of of IN cord-287815-alv30uk5 72 25 cisternae cisternae NNP cord-287815-alv30uk5 72 26 . . . cord-287815-alv30uk5 73 1 Second second RB cord-287815-alv30uk5 73 2 , , , cord-287815-alv30uk5 73 3 the the DT cord-287815-alv30uk5 73 4 enzymes enzyme NNS cord-287815-alv30uk5 73 5 studied study VBN cord-287815-alv30uk5 73 6 have have VBP cord-287815-alv30uk5 73 7 been be VBN cord-287815-alv30uk5 73 8 separated separate VBN cord-287815-alv30uk5 73 9 into into IN cord-287815-alv30uk5 73 10 only only RB cord-287815-alv30uk5 73 11 three three CD cord-287815-alv30uk5 73 12 fractions fraction NNS cord-287815-alv30uk5 73 13 , , , cord-287815-alv30uk5 73 14 the the DT cord-287815-alv30uk5 73 15 highest high JJS cord-287815-alv30uk5 73 16 density density NN cord-287815-alv30uk5 73 17 fraclions fraclion NNS cord-287815-alv30uk5 73 18 containing contain VBG cord-287815-alv30uk5 73 19 enzymes enzyme NNS cord-287815-alv30uk5 73 20 acting act VBG cord-287815-alv30uk5 73 21 early early RB cord-287815-alv30uk5 73 22 in in IN cord-287815-alv30uk5 73 23 glycosylation glycosylation NN cord-287815-alv30uk5 73 24 ( ( -LRB- cord-287815-alv30uk5 73 25 glucosidase glucosidase NN cord-287815-alv30uk5 73 26 , , , cord-287815-alv30uk5 73 27 enzymes enzyme NNS cord-287815-alv30uk5 73 28 involved involve VBN cord-287815-alv30uk5 73 29 in in IN cord-287815-alv30uk5 73 30 generating generate VBG cord-287815-alv30uk5 73 31 mannose mannose JJ cord-287815-alv30uk5 73 32 6-phosphates 6-phosphates CD cord-287815-alv30uk5 73 33 on on IN cord-287815-alv30uk5 73 34 lysosomal lysosomal JJ cord-287815-alv30uk5 73 35 enzymes enzyme NNS cord-287815-alv30uk5 73 36 ) ) -RRB- cord-287815-alv30uk5 73 37 and and CC cord-287815-alv30uk5 73 38 the the DT cord-287815-alv30uk5 73 39 lightest light JJS cord-287815-alv30uk5 73 40 density density NN cord-287815-alv30uk5 73 41 fractions fraction NNS cord-287815-alv30uk5 73 42 containing contain VBG cord-287815-alv30uk5 73 43 terminally terminally RB cord-287815-alv30uk5 73 44 acting act VBG cord-287815-alv30uk5 73 45 glycosyltransferases glycosyltransferase NNS cord-287815-alv30uk5 73 46 ( ( -LRB- cord-287815-alv30uk5 73 47 galactosyl galactosyl NNP cord-287815-alv30uk5 73 48 and and CC cord-287815-alv30uk5 73 49 sialyltransferases sialyltransferases NNP cord-287815-alv30uk5 73 50 ) ) -RRB- cord-287815-alv30uk5 73 51 . . . cord-287815-alv30uk5 74 1 The the DT cord-287815-alv30uk5 74 2 five five CD cord-287815-alv30uk5 74 3 enzymes enzyme NNS cord-287815-alv30uk5 74 4 1 1 CD cord-287815-alv30uk5 74 5 hat hat NN cord-287815-alv30uk5 74 6 are be VBP cord-287815-alv30uk5 74 7 involved involve VBN cord-287815-alv30uk5 74 8 in in IN cord-287815-alv30uk5 74 9 " " `` cord-287815-alv30uk5 74 10 intermediate intermediate JJ cord-287815-alv30uk5 74 11 " " '' cord-287815-alv30uk5 74 12 processing processing NN cord-287815-alv30uk5 74 13 steps step NNS cord-287815-alv30uk5 74 14 ( ( -LRB- cord-287815-alv30uk5 75 1 manrnosidase manrnosidase NNP cord-287815-alv30uk5 75 2 I I NNP cord-287815-alv30uk5 75 3 and and CC cord-287815-alv30uk5 75 4 II II NNP cord-287815-alv30uk5 75 5 , , , cord-287815-alv30uk5 75 6 GlcNAc GlcNAc NNP cord-287815-alv30uk5 75 7 transferase transferase NN cord-287815-alv30uk5 75 8 I I NNP cord-287815-alv30uk5 75 9 , , , cord-287815-alv30uk5 75 10 II II NNP cord-287815-alv30uk5 75 11 , , , cord-287815-alv30uk5 75 12 and and CC cord-287815-alv30uk5 75 13 IV IV NNP cord-287815-alv30uk5 75 14 , , , cord-287815-alv30uk5 75 15 and and CC cord-287815-alv30uk5 75 16 fucosyltransferase fucosyltransferase NN cord-287815-alv30uk5 75 17 ) ) -RRB- cord-287815-alv30uk5 75 18 were be VBD cord-287815-alv30uk5 75 19 all all DT cord-287815-alv30uk5 75 20 found find VBN cord-287815-alv30uk5 75 21 to to TO cord-287815-alv30uk5 75 22 cosediment cosediment VB cord-287815-alv30uk5 75 23 in in IN cord-287815-alv30uk5 75 24 a a DT cord-287815-alv30uk5 75 25 single single JJ cord-287815-alv30uk5 75 26 peak peak NN cord-287815-alv30uk5 75 27 of of IN cord-287815-alv30uk5 75 28 intermediate intermediate JJ cord-287815-alv30uk5 75 29 density density NN cord-287815-alv30uk5 75 30 . . . cord-287815-alv30uk5 76 1 Thus thus RB cord-287815-alv30uk5 76 2 , , , cord-287815-alv30uk5 76 3 although although IN cord-287815-alv30uk5 76 4 consistent consistent JJ cord-287815-alv30uk5 76 5 with with IN cord-287815-alv30uk5 76 6 the the DT cord-287815-alv30uk5 76 7 existence existence NN cord-287815-alv30uk5 76 8 of of IN cord-287815-alv30uk5 76 9 at at RB cord-287815-alv30uk5 76 10 least least RBS cord-287815-alv30uk5 76 11 three three CD cord-287815-alv30uk5 76 12 physically physically RB cord-287815-alv30uk5 76 13 and and CC cord-287815-alv30uk5 76 14 functionally functionally RB cord-287815-alv30uk5 76 15 distinct distinct JJ cord-287815-alv30uk5 76 16 compartments compartment NNS cord-287815-alv30uk5 76 17 , , , cord-287815-alv30uk5 76 18 these these DT cord-287815-alv30uk5 76 19 observations observation NNS cord-287815-alv30uk5 76 20 also also RB cord-287815-alv30uk5 76 21 suggest suggest VBP cord-287815-alv30uk5 76 22 that that IN cord-287815-alv30uk5 76 23 many many JJ cord-287815-alv30uk5 76 24 of of IN cord-287815-alv30uk5 76 25 the the DT cord-287815-alv30uk5 76 26 carbohydrate carbohydrate NN cord-287815-alv30uk5 76 27 processing processing NN cord-287815-alv30uk5 76 28 steps step NNS cord-287815-alv30uk5 76 29 may may MD cord-287815-alv30uk5 76 30 occur occur VB cord-287815-alv30uk5 76 31 within within IN cord-287815-alv30uk5 76 32 a a DT cord-287815-alv30uk5 76 33 single single JJ cord-287815-alv30uk5 76 34 compartment compartment NN cord-287815-alv30uk5 76 35 . . . cord-287815-alv30uk5 77 1 Since since IN cord-287815-alv30uk5 77 2 the the DT cord-287815-alv30uk5 77 3 enzymes enzyme NNS cord-287815-alv30uk5 77 4 involved involve VBN cord-287815-alv30uk5 77 5 in in IN cord-287815-alv30uk5 77 6 N n CD cord-287815-alv30uk5 77 7 - - HYPH cord-287815-alv30uk5 77 8 glycosylation glycosylation NN cord-287815-alv30uk5 77 9 act act NN cord-287815-alv30uk5 77 10 sequentially sequentially RB cord-287815-alv30uk5 77 11 ( ( -LRB- cord-287815-alv30uk5 77 12 and and CC cord-287815-alv30uk5 77 13 specifically specifically RB cord-287815-alv30uk5 77 14 ) ) -RRB- cord-287815-alv30uk5 78 1 ( ( -LRB- cord-287815-alv30uk5 78 2 that that DT cord-287815-alv30uk5 78 3 is is RB cord-287815-alv30uk5 78 4 , , , cord-287815-alv30uk5 78 5 mannosidase mannosidase NN cord-287815-alv30uk5 78 6 I -PRON- PRP cord-287815-alv30uk5 78 7 creates create VBZ cord-287815-alv30uk5 78 8 the the DT cord-287815-alv30uk5 78 9 substrate substrate NN cord-287815-alv30uk5 78 10 for for IN cord-287815-alv30uk5 78 11 GlcNAc GlcNAc NNP cord-287815-alv30uk5 78 12 transferase transferase NN cord-287815-alv30uk5 78 13 , , , cord-287815-alv30uk5 78 14 which which WDT cord-287815-alv30uk5 78 15 creates create VBZ cord-287815-alv30uk5 78 16 the the DT cord-287815-alv30uk5 78 17 substrate substrate NN cord-287815-alv30uk5 78 18 for for IN cord-287815-alv30uk5 78 19 mannosidase mannosidase NNP cord-287815-alv30uk5 78 20 II II NNP cord-287815-alv30uk5 78 21 , , , cord-287815-alv30uk5 78 22 which which WDT cord-287815-alv30uk5 78 23 creates create VBZ cord-287815-alv30uk5 78 24 the the DT cord-287815-alv30uk5 78 25 substrate substrate NN cord-287815-alv30uk5 78 26 for for IN cord-287815-alv30uk5 78 27 galactosyltransferase galactosyltransferase NNP cord-287815-alv30uk5 78 28 , , , cord-287815-alv30uk5 78 29 etc etc FW cord-287815-alv30uk5 78 30 . . . cord-287815-alv30uk5 78 31 ) ) -RRB- cord-287815-alv30uk5 79 1 , , , cord-287815-alv30uk5 79 2 there there EX cord-287815-alv30uk5 79 3 is be VBZ cord-287815-alv30uk5 79 4 no no DT cord-287815-alv30uk5 79 5 a a FW cord-287815-alv30uk5 79 6 priori priori FW cord-287815-alv30uk5 79 7 need need NN cord-287815-alv30uk5 79 8 for for IN cord-287815-alv30uk5 79 9 physical physical JJ cord-287815-alv30uk5 79 10 separation separation NN cord-287815-alv30uk5 79 11 to to TO cord-287815-alv30uk5 79 12 ensure ensure VB cord-287815-alv30uk5 79 13 proper proper JJ cord-287815-alv30uk5 79 14 processing processing NN cord-287815-alv30uk5 79 15 . . . cord-287815-alv30uk5 80 1 Indeed indeed RB cord-287815-alv30uk5 80 2 , , , cord-287815-alv30uk5 80 3 having have VBG cord-287815-alv30uk5 80 4 GlcNAc GlcNAc NNP cord-287815-alv30uk5 80 5 transferase transferase NN cord-287815-alv30uk5 80 6 and and CC cord-287815-alv30uk5 80 7 galactosyltransferase galactosyltransferase NN cord-287815-alv30uk5 80 8 in in IN cord-287815-alv30uk5 80 9 a a DT cord-287815-alv30uk5 80 10 common common JJ cord-287815-alv30uk5 80 11 compartment compartment NN cord-287815-alv30uk5 80 12 would would MD cord-287815-alv30uk5 80 13 explain explain VB cord-287815-alv30uk5 80 14 the the DT cord-287815-alv30uk5 80 15 existence existence NN cord-287815-alv30uk5 80 16 of of IN cord-287815-alv30uk5 80 17 lactosamine lactosamine NNP cord-287815-alv30uk5 80 18 repeats repeat VBZ cord-287815-alv30uk5 80 19 in in IN cord-287815-alv30uk5 80 20 the the DT cord-287815-alv30uk5 80 21 terminal terminal JJ cord-287815-alv30uk5 80 22 chains chain NNS cord-287815-alv30uk5 80 23 of of IN cord-287815-alv30uk5 80 24 many many JJ cord-287815-alv30uk5 80 25 glycoproteins glycoprotein NNS cord-287815-alv30uk5 80 26 ( ( -LRB- cord-287815-alv30uk5 80 27 Cummings Cummings NNP cord-287815-alv30uk5 80 28 and and CC cord-287815-alv30uk5 80 29 Kornfeld Kornfeld NNP cord-287815-alv30uk5 80 30 , , , cord-287815-alv30uk5 80 31 1984 1984 CD cord-287815-alv30uk5 80 32 ; ; . cord-287815-alv30uk5 81 1 Howe Howe NNP cord-287815-alv30uk5 81 2 et et NNP cord-287815-alv30uk5 81 3 al al NNP cord-287815-alv30uk5 81 4 . . NNP cord-287815-alv30uk5 81 5 , , , cord-287815-alv30uk5 81 6 1988 1988 CD cord-287815-alv30uk5 81 7 ) ) -RRB- cord-287815-alv30uk5 81 8 . . . cord-287815-alv30uk5 82 1 A a DT cord-287815-alv30uk5 82 2 further further JJ cord-287815-alv30uk5 82 3 reason reason NN cord-287815-alv30uk5 82 4 for for IN cord-287815-alv30uk5 82 5 caution caution NN cord-287815-alv30uk5 82 6 in in IN cord-287815-alv30uk5 82 7 interpreting interpret VBG cord-287815-alv30uk5 82 8 existing exist VBG cord-287815-alv30uk5 82 9 imlmunocytochemistry imlmunocytochemistry NN cord-287815-alv30uk5 82 10 and and CC cord-287815-alv30uk5 82 11 fractionation fractionation NN cord-287815-alv30uk5 82 12 results result NNS cord-287815-alv30uk5 82 13 is be VBZ cord-287815-alv30uk5 82 14 the the DT cord-287815-alv30uk5 82 15 growing grow VBG cord-287815-alv30uk5 82 16 appreciation appreciation NN cord-287815-alv30uk5 82 17 of of IN cord-287815-alv30uk5 82 18 the the DT cord-287815-alv30uk5 82 19 fact fact NN cord-287815-alv30uk5 82 20 that that IN cord-287815-alv30uk5 82 21 the the DT cord-287815-alv30uk5 82 22 individual individual JJ cord-287815-alv30uk5 82 23 Golgi Golgi NNP cord-287815-alv30uk5 82 24 cister cister NN cord-287815-alv30uk5 83 1 -Inae -Inae NNP cord-287815-alv30uk5 83 2 - - : cord-287815-alv30uk5 83 3 and and CC cord-287815-alv30uk5 83 4 perhaps perhaps RB cord-287815-alv30uk5 83 5 even even RB cord-287815-alv30uk5 83 6 entire entire JJ cord-287815-alv30uk5 83 7 stacks stack NNS cord-287815-alv30uk5 83 8 - - : cord-287815-alv30uk5 83 9 may may MD cord-287815-alv30uk5 83 10 not not RB cord-287815-alv30uk5 83 11 be be VB cord-287815-alv30uk5 83 12 as as RB cord-287815-alv30uk5 83 13 datic datic JJ cord-287815-alv30uk5 83 14 and and CC cord-287815-alv30uk5 83 15 structurally structurally RB cord-287815-alv30uk5 83 16 distinct distinct JJ cord-287815-alv30uk5 83 17 as as IN cord-287815-alv30uk5 83 18 we -PRON- PRP cord-287815-alv30uk5 83 19 have have VBP cord-287815-alv30uk5 83 20 come come VBN cord-287815-alv30uk5 83 21 to to TO cord-287815-alv30uk5 83 22 believe believe VB cord-287815-alv30uk5 83 23 . . . cord-287815-alv30uk5 84 1 IExamination IExamination NNP cord-287815-alv30uk5 84 2 of of IN cord-287815-alv30uk5 84 3 the the DT cord-287815-alv30uk5 84 4 Golgi Golgi NNP cord-287815-alv30uk5 84 5 using use VBG cord-287815-alv30uk5 84 6 high high JJ cord-287815-alv30uk5 84 7 voltage voltage NN cord-287815-alv30uk5 84 8 electron electron NN cord-287815-alv30uk5 84 9 milcroscopy milcroscopy NN cord-287815-alv30uk5 84 10 has have VBZ cord-287815-alv30uk5 84 11 suggested suggest VBN cord-287815-alv30uk5 84 12 that that IN cord-287815-alv30uk5 84 13 adjacent adjacent JJ cord-287815-alv30uk5 84 14 stacks stack NNS cord-287815-alv30uk5 84 15 of of IN cord-287815-alv30uk5 84 16 cisternae cisternae NNP cord-287815-alv30uk5 84 17 ( ( -LRB- cord-287815-alv30uk5 84 18 are be VBP cord-287815-alv30uk5 84 19 joined join VBN cord-287815-alv30uk5 84 20 via via IN cord-287815-alv30uk5 84 21 extensive extensive JJ cord-287815-alv30uk5 84 22 tubular tubular JJ cord-287815-alv30uk5 84 23 interconnections interconnection NNS cord-287815-alv30uk5 84 24 ( ( -LRB- cord-287815-alv30uk5 84 25 Rambourg Rambourg NNP cord-287815-alv30uk5 84 26 and and CC cord-287815-alv30uk5 84 27 Clermont Clermont NNP cord-287815-alv30uk5 84 28 , , , cord-287815-alv30uk5 84 29 1990 1990 CD cord-287815-alv30uk5 84 30 ) ) -RRB- cord-287815-alv30uk5 84 31 . . . cord-287815-alv30uk5 85 1 Similarly similarly RB cord-287815-alv30uk5 85 2 , , , cord-287815-alv30uk5 85 3 real real JJ cord-287815-alv30uk5 85 4 - - HYPH cord-287815-alv30uk5 85 5 time time NN cord-287815-alv30uk5 85 6 imaging imaging NN cord-287815-alv30uk5 85 7 of of IN cord-287815-alv30uk5 85 8 Iliving Iliving NNP cord-287815-alv30uk5 85 9 cells cell NNS cord-287815-alv30uk5 85 10 labeled label VBN cord-287815-alv30uk5 85 11 with with IN cord-287815-alv30uk5 85 12 the the DT cord-287815-alv30uk5 85 13 fluorescent fluorescent JJ cord-287815-alv30uk5 85 14 lipid lipid NN cord-287815-alv30uk5 85 15 analog analog NN cord-287815-alv30uk5 85 16 NBD NBD NNP cord-287815-alv30uk5 85 17 - - HYPH cord-287815-alv30uk5 85 18 Iceramide Iceramide NNP cord-287815-alv30uk5 85 19 has have VBZ cord-287815-alv30uk5 85 20 revealed reveal VBN cord-287815-alv30uk5 85 21 that that IN cord-287815-alv30uk5 85 22 the the DT cord-287815-alv30uk5 85 23 Golgi Golgi NNP cord-287815-alv30uk5 85 24 is be VBZ cord-287815-alv30uk5 85 25 capable capable JJ cord-287815-alv30uk5 85 26 of of IN cord-287815-alv30uk5 85 27 forming form VBG cord-287815-alv30uk5 85 28 , , , cord-287815-alv30uk5 85 29 a a DT cord-287815-alv30uk5 85 30 large large JJ cord-287815-alv30uk5 85 31 number number NN cord-287815-alv30uk5 85 32 of of IN cord-287815-alv30uk5 85 33 tubules tubule NNS cord-287815-alv30uk5 85 34 that that WDT cord-287815-alv30uk5 85 35 may may MD cord-287815-alv30uk5 85 36 serve serve VB cord-287815-alv30uk5 85 37 to to TO cord-287815-alv30uk5 85 38 connect connect VB cord-287815-alv30uk5 85 39 other-'wise other-'wise RB cord-287815-alv30uk5 85 40 " " `` cord-287815-alv30uk5 85 41 separate separate JJ cord-287815-alv30uk5 85 42 " " '' cord-287815-alv30uk5 85 43 stacks stack NNS cord-287815-alv30uk5 85 44 of of IN cord-287815-alv30uk5 85 45 cisternae cisternae NN cord-287815-alv30uk5 85 46 ( ( -LRB- cord-287815-alv30uk5 85 47 Cooper Cooper NNP cord-287815-alv30uk5 85 48 et et NNP cord-287815-alv30uk5 85 49 al al NNP cord-287815-alv30uk5 85 50 . . NNP cord-287815-alv30uk5 85 51 , , , cord-287815-alv30uk5 85 52 1990 1990 CD cord-287815-alv30uk5 85 53 ) ) -RRB- cord-287815-alv30uk5 85 54 . . . cord-287815-alv30uk5 86 1 Whether whether IN cord-287815-alv30uk5 86 2 the the DT cord-287815-alv30uk5 86 3 tubules tubule NNS cord-287815-alv30uk5 86 4 form form VBP cord-287815-alv30uk5 86 5 connections connection NNS cord-287815-alv30uk5 86 6 between between IN cord-287815-alv30uk5 86 7 cisternae cisternae NNP cord-287815-alv30uk5 86 8 in in IN cord-287815-alv30uk5 86 9 register register NN cord-287815-alv30uk5 86 10 ( ( -LRB- cord-287815-alv30uk5 86 11 i.e. i.e. FW cord-287815-alv30uk5 86 12 , , , cord-287815-alv30uk5 86 13 cis cis NNP cord-287815-alv30uk5 86 14 to to IN cord-287815-alv30uk5 86 15 cis cis NNP cord-287815-alv30uk5 86 16 , , , cord-287815-alv30uk5 86 17 medial medial JJ cord-287815-alv30uk5 86 18 to to IN cord-287815-alv30uk5 86 19 medial medial JJ cord-287815-alv30uk5 86 20 ) ) -RRB- cord-287815-alv30uk5 86 21 or or CC cord-287815-alv30uk5 86 22 out out IN cord-287815-alv30uk5 86 23 of of IN cord-287815-alv30uk5 86 24 register register NN cord-287815-alv30uk5 87 1 ( ( -LRB- cord-287815-alv30uk5 87 2 cis cis NNP cord-287815-alv30uk5 87 3 to to IN cord-287815-alv30uk5 87 4 medial medial NNP cord-287815-alv30uk5 87 5 ) ) -RRB- cord-287815-alv30uk5 87 6 is be VBZ cord-287815-alv30uk5 87 7 unknown unknown JJ cord-287815-alv30uk5 87 8 . . . cord-287815-alv30uk5 88 1 The the DT cord-287815-alv30uk5 88 2 possibility possibility NN cord-287815-alv30uk5 88 3 must must MD cord-287815-alv30uk5 88 4 also also RB cord-287815-alv30uk5 88 5 be be VB cord-287815-alv30uk5 88 6 considered consider VBN cord-287815-alv30uk5 88 7 that that IN cord-287815-alv30uk5 88 8 even even RB cord-287815-alv30uk5 88 9 within within IN cord-287815-alv30uk5 88 10 a a DT cord-287815-alv30uk5 88 11 single single JJ cord-287815-alv30uk5 88 12 stack stack NN cord-287815-alv30uk5 88 13 , , , cord-287815-alv30uk5 88 14 adjacent adjacent JJ cord-287815-alv30uk5 88 15 cisternae cisternae NNP cord-287815-alv30uk5 88 16 might may MD cord-287815-alv30uk5 88 17 at at IN cord-287815-alv30uk5 88 18 least least RBS cord-287815-alv30uk5 88 19 transiently transiently RB cord-287815-alv30uk5 88 20 possess possess VB cord-287815-alv30uk5 88 21 similar similar JJ cord-287815-alv30uk5 88 22 tubular tubular JJ cord-287815-alv30uk5 88 23 interconnections interconnection NNS cord-287815-alv30uk5 88 24 . . . cord-287815-alv30uk5 89 1 Anyway anyway RB cord-287815-alv30uk5 89 2 ? ? . cord-287815-alv30uk5 90 1 A a DT cord-287815-alv30uk5 90 2 question question NN cord-287815-alv30uk5 90 3 that that WDT cord-287815-alv30uk5 90 4 clearly clearly RB cord-287815-alv30uk5 90 5 needs need VBZ cord-287815-alv30uk5 90 6 discussion discussion NN cord-287815-alv30uk5 90 7 at at IN cord-287815-alv30uk5 90 8 this this DT cord-287815-alv30uk5 90 9 point point NN cord-287815-alv30uk5 90 10 is be VBZ cord-287815-alv30uk5 90 11 what what WP cord-287815-alv30uk5 90 12 exactly exactly RB cord-287815-alv30uk5 90 13 defines define VBZ cord-287815-alv30uk5 90 14 a a DT cord-287815-alv30uk5 90 15 cellular cellular JJ cord-287815-alv30uk5 90 16 compartment compartment NN cord-287815-alv30uk5 90 17 . . . cord-287815-alv30uk5 91 1 Classically classically RB cord-287815-alv30uk5 91 2 , , , cord-287815-alv30uk5 91 3 membrane membrane NN cord-287815-alv30uk5 91 4 - - HYPH cord-287815-alv30uk5 91 5 bounded bound VBN cord-287815-alv30uk5 91 6 compartments compartment NNS cord-287815-alv30uk5 91 7 have have VBP cord-287815-alv30uk5 91 8 been be VBN cord-287815-alv30uk5 91 9 viewed view VBN cord-287815-alv30uk5 91 10 as as IN cord-287815-alv30uk5 91 11 comprising comprise VBG cord-287815-alv30uk5 91 12 physically physically RB cord-287815-alv30uk5 91 13 distinct distinct JJ cord-287815-alv30uk5 91 14 entities entity NNS cord-287815-alv30uk5 91 15 each each DT cord-287815-alv30uk5 91 16 with with IN cord-287815-alv30uk5 91 17 its -PRON- PRP$ cord-287815-alv30uk5 91 18 own own JJ cord-287815-alv30uk5 91 19 distinct distinct JJ cord-287815-alv30uk5 91 20 protein protein NN cord-287815-alv30uk5 91 21 compositions composition NNS cord-287815-alv30uk5 91 22 and and CC cord-287815-alv30uk5 91 23 , , , cord-287815-alv30uk5 91 24 presumably presumably RB cord-287815-alv30uk5 91 25 , , , cord-287815-alv30uk5 91 26 unique unique JJ cord-287815-alv30uk5 91 27 functions function NNS cord-287815-alv30uk5 91 28 . . . cord-287815-alv30uk5 92 1 Accordingly accordingly RB cord-287815-alv30uk5 92 2 , , , cord-287815-alv30uk5 92 3 all all DT cord-287815-alv30uk5 92 4 of of IN cord-287815-alv30uk5 92 5 any any DT cord-287815-alv30uk5 92 6 one one CD cord-287815-alv30uk5 92 7 type type NN cord-287815-alv30uk5 92 8 of of IN cord-287815-alv30uk5 92 9 organelle organelle NN cord-287815-alv30uk5 92 10 can can MD cord-287815-alv30uk5 92 11 be be VB cord-287815-alv30uk5 92 12 considered consider VBN cord-287815-alv30uk5 92 13 a a DT cord-287815-alv30uk5 92 14 compartment compartment NN cord-287815-alv30uk5 92 15 , , , cord-287815-alv30uk5 92 16 but but CC cord-287815-alv30uk5 92 17 so so RB cord-287815-alv30uk5 92 18 can can MD cord-287815-alv30uk5 92 19 a a DT cord-287815-alv30uk5 92 20 distinct distinct JJ cord-287815-alv30uk5 92 21 region region NN cord-287815-alv30uk5 92 22 ( ( -LRB- cord-287815-alv30uk5 92 23 or or CC cord-287815-alv30uk5 92 24 " " `` cord-287815-alv30uk5 92 25 subcompartment subcompartment JJ cord-287815-alv30uk5 92 26 " " '' cord-287815-alv30uk5 92 27 ) ) -RRB- cord-287815-alv30uk5 92 28 within within IN cord-287815-alv30uk5 92 29 an an DT cord-287815-alv30uk5 92 30 organelle organelle NN cord-287815-alv30uk5 92 31 . . . cord-287815-alv30uk5 93 1 By by IN cord-287815-alv30uk5 93 2 this this DT cord-287815-alv30uk5 93 3 criterion criterion NN cord-287815-alv30uk5 93 4 , , , cord-287815-alv30uk5 93 5 compartment compartment NN cord-287815-alv30uk5 93 6 boundaries boundary NNS cord-287815-alv30uk5 93 7 should should MD cord-287815-alv30uk5 93 8 be be VB cord-287815-alv30uk5 93 9 easily easily RB cord-287815-alv30uk5 93 10 delineated delineate VBN cord-287815-alv30uk5 93 11 by by IN cord-287815-alv30uk5 93 12 immunoelectron immunoelectron NNP cord-287815-alv30uk5 93 13 microscopic microscopic JJ cord-287815-alv30uk5 93 14 localization localization NN cord-287815-alv30uk5 93 15 of of IN cord-287815-alv30uk5 93 16 resident resident JJ cord-287815-alv30uk5 93 17 marker marker NN cord-287815-alv30uk5 93 18 proteins protein NNS cord-287815-alv30uk5 93 19 . . . cord-287815-alv30uk5 94 1 However however RB cord-287815-alv30uk5 94 2 , , , cord-287815-alv30uk5 94 3 this this DT cord-287815-alv30uk5 94 4 simple simple JJ cord-287815-alv30uk5 94 5 view view NN cord-287815-alv30uk5 94 6 is be VBZ cord-287815-alv30uk5 94 7 complicated complicate VBN cord-287815-alv30uk5 94 8 by by IN cord-287815-alv30uk5 94 9 several several JJ cord-287815-alv30uk5 94 10 factors factor NNS cord-287815-alv30uk5 94 11 . . . cord-287815-alv30uk5 95 1 For for IN cord-287815-alv30uk5 95 2 example example NN cord-287815-alv30uk5 95 3 , , , cord-287815-alv30uk5 95 4 even even RB cord-287815-alv30uk5 95 5 the the DT cord-287815-alv30uk5 95 6 localization localization NN cord-287815-alv30uk5 95 7 of of IN cord-287815-alv30uk5 95 8 two two CD cord-287815-alv30uk5 95 9 Golgi Golgi NNP cord-287815-alv30uk5 95 10 enzymes enzyme NNS cord-287815-alv30uk5 95 11 to to IN cord-287815-alv30uk5 95 12 different different JJ cord-287815-alv30uk5 95 13 cisternae cisternae NN cord-287815-alv30uk5 95 14 by by IN cord-287815-alv30uk5 95 15 double double JJ cord-287815-alv30uk5 95 16 label label NN cord-287815-alv30uk5 95 17 immunoelectron immunoelectron NNP cord-287815-alv30uk5 95 18 microscopy microscopy NN cord-287815-alv30uk5 95 19 might may MD cord-287815-alv30uk5 95 20 not not RB cord-287815-alv30uk5 95 21 unequivocally unequivocally RB cord-287815-alv30uk5 95 22 demonstrate demonstrate VB cord-287815-alv30uk5 95 23 that that IN cord-287815-alv30uk5 95 24 they -PRON- PRP cord-287815-alv30uk5 95 25 are be VBP cord-287815-alv30uk5 95 26 present present JJ cord-287815-alv30uk5 95 27 in in IN cord-287815-alv30uk5 95 28 physically physically RB cord-287815-alv30uk5 95 29 distinct distinct JJ cord-287815-alv30uk5 95 30 compartments compartment NNS cord-287815-alv30uk5 95 31 . . . cord-287815-alv30uk5 96 1 Such such JJ cord-287815-alv30uk5 96 2 a a DT cord-287815-alv30uk5 96 3 distribution distribution NN cord-287815-alv30uk5 96 4 of of IN cord-287815-alv30uk5 96 5 enzymes enzyme NNS cord-287815-alv30uk5 96 6 could could MD cord-287815-alv30uk5 96 7 reflect reflect VB cord-287815-alv30uk5 96 8 the the DT cord-287815-alv30uk5 96 9 existence existence NN cord-287815-alv30uk5 96 10 of of IN cord-287815-alv30uk5 96 11 subdomains subdomain NNS cord-287815-alv30uk5 96 12 in in IN cord-287815-alv30uk5 96 13 an an DT cord-287815-alv30uk5 96 14 otherwise otherwise RB cord-287815-alv30uk5 96 15 continuous continuous JJ cord-287815-alv30uk5 96 16 membrane membrane NN cord-287815-alv30uk5 96 17 array array NN cord-287815-alv30uk5 96 18 , , , cord-287815-alv30uk5 96 19 analogous analogous JJ cord-287815-alv30uk5 96 20 to to IN cord-287815-alv30uk5 96 21 the the DT cord-287815-alv30uk5 96 22 lateral lateral JJ cord-287815-alv30uk5 96 23 heterogeneity heterogeneity NN cord-287815-alv30uk5 96 24 found find VBN cord-287815-alv30uk5 96 25 between between IN cord-287815-alv30uk5 96 26 the the DT cord-287815-alv30uk5 96 27 rough rough JJ cord-287815-alv30uk5 96 28 and and CC cord-287815-alv30uk5 96 29 the the DT cord-287815-alv30uk5 96 30 smooth smooth JJ cord-287815-alv30uk5 96 31 ER er NN cord-287815-alv30uk5 96 32 . . . cord-287815-alv30uk5 97 1 Conversely conversely RB cord-287815-alv30uk5 97 2 , , , cord-287815-alv30uk5 97 3 markers marker NNS cord-287815-alv30uk5 97 4 may may MD cord-287815-alv30uk5 97 5 be be VB cord-287815-alv30uk5 97 6 segregated segregate VBN cord-287815-alv30uk5 97 7 into into IN cord-287815-alv30uk5 97 8 physically physically RB cord-287815-alv30uk5 97 9 distinct distinct JJ cord-287815-alv30uk5 97 10 membranes membrane NNS cord-287815-alv30uk5 97 11 that that WDT cord-287815-alv30uk5 97 12 nevertheless nevertheless RB cord-287815-alv30uk5 97 13 remain remain VBP cord-287815-alv30uk5 97 14 functionally functionally RB cord-287815-alv30uk5 97 15 continuous continuous JJ cord-287815-alv30uk5 97 16 by by IN cord-287815-alv30uk5 97 17 repeated repeat VBN cord-287815-alv30uk5 97 18 membrane membrane NN cord-287815-alv30uk5 97 19 fissions fission NNS cord-287815-alv30uk5 97 20 and and CC cord-287815-alv30uk5 97 21 fusions fusion NNS cord-287815-alv30uk5 97 22 or or CC cord-287815-alv30uk5 97 23 transient transient JJ cord-287815-alv30uk5 97 24 tubular tubular JJ cord-287815-alv30uk5 97 25 interconnections interconnection NNS cord-287815-alv30uk5 97 26 . . . cord-287815-alv30uk5 98 1 The the DT cord-287815-alv30uk5 98 2 existence existence NN cord-287815-alv30uk5 98 3 of of IN cord-287815-alv30uk5 98 4 such such JJ cord-287815-alv30uk5 98 5 homotypic homotypic JJ cord-287815-alv30uk5 98 6 interactions interaction NNS cord-287815-alv30uk5 98 7 - - : cord-287815-alv30uk5 98 8 interactions interaction NNS cord-287815-alv30uk5 98 9 among among IN cord-287815-alv30uk5 98 10 " " `` cord-287815-alv30uk5 98 11 like like IN cord-287815-alv30uk5 98 12 " " '' cord-287815-alv30uk5 98 13 elements element NNS cord-287815-alv30uk5 98 14 - - , cord-287815-alv30uk5 98 15 would would MD cord-287815-alv30uk5 98 16 play play VB cord-287815-alv30uk5 98 17 an an DT cord-287815-alv30uk5 98 18 important important JJ cord-287815-alv30uk5 98 19 role role NN cord-287815-alv30uk5 98 20 in in IN cord-287815-alv30uk5 98 21 preserving preserve VBG cord-287815-alv30uk5 98 22 continuity continuity NN cord-287815-alv30uk5 98 23 among among IN cord-287815-alv30uk5 98 24 equivalent equivalent JJ cord-287815-alv30uk5 98 25 but but CC cord-287815-alv30uk5 98 26 physically physically RB cord-287815-alv30uk5 98 27 separated separate VBN cord-287815-alv30uk5 98 28 organelles organelle NNS cord-287815-alv30uk5 98 29 . . . cord-287815-alv30uk5 99 1 Thus thus RB cord-287815-alv30uk5 99 2 , , , cord-287815-alv30uk5 99 3 the the DT cord-287815-alv30uk5 99 4 simple simple JJ cord-287815-alv30uk5 99 5 test test NN cord-287815-alv30uk5 99 6 of of IN cord-287815-alv30uk5 99 7 localizing localize VBG cord-287815-alv30uk5 99 8 different different JJ cord-287815-alv30uk5 99 9 markers marker NNS cord-287815-alv30uk5 99 10 to to IN cord-287815-alv30uk5 99 11 distinct distinct JJ cord-287815-alv30uk5 99 12 membranes membrane NNS cord-287815-alv30uk5 99 13 can can MD cord-287815-alv30uk5 99 14 not not RB cord-287815-alv30uk5 99 15 by by IN cord-287815-alv30uk5 99 16 itself -PRON- PRP cord-287815-alv30uk5 99 17 serve serve VBP cord-287815-alv30uk5 99 18 to to TO cord-287815-alv30uk5 99 19 identify identify VB cord-287815-alv30uk5 99 20 distinct distinct JJ cord-287815-alv30uk5 99 21 compartments compartment NNS cord-287815-alv30uk5 99 22 . . . cord-287815-alv30uk5 100 1 The the DT cord-287815-alv30uk5 100 2 definition definition NN cord-287815-alv30uk5 100 3 of of IN cord-287815-alv30uk5 100 4 a a DT cord-287815-alv30uk5 100 5 compartment compartment NN cord-287815-alv30uk5 100 6 is be VBZ cord-287815-alv30uk5 100 7 further further RB cord-287815-alv30uk5 100 8 confounded confound VBN cord-287815-alv30uk5 100 9 when when WRB cord-287815-alv30uk5 100 10 considering consider VBG cord-287815-alv30uk5 100 11 organelles organelle NNS cord-287815-alv30uk5 100 12 that that WDT cord-287815-alv30uk5 100 13 are be VBP cord-287815-alv30uk5 100 14 also also RB cord-287815-alv30uk5 100 15 involved involve VBN cord-287815-alv30uk5 100 16 in in IN cord-287815-alv30uk5 100 17 membrane membrane NN cord-287815-alv30uk5 100 18 traffic traffic NN cord-287815-alv30uk5 100 19 . . . cord-287815-alv30uk5 101 1 Given give VBN cord-287815-alv30uk5 101 2 that that IN cord-287815-alv30uk5 101 3 there there EX cord-287815-alv30uk5 101 4 is be VBZ cord-287815-alv30uk5 101 5 likely likely JJ cord-287815-alv30uk5 101 6 to to TO cord-287815-alv30uk5 101 7 be be VB cord-287815-alv30uk5 101 8 continuous continuous JJ cord-287815-alv30uk5 101 9 transport transport NN cord-287815-alv30uk5 101 10 and and CC cord-287815-alv30uk5 101 11 recycling recycling NN cord-287815-alv30uk5 101 12 of of IN cord-287815-alv30uk5 101 13 membrane membrane NN cord-287815-alv30uk5 101 14 components component NNS cord-287815-alv30uk5 101 15 between between IN cord-287815-alv30uk5 101 16 such such JJ cord-287815-alv30uk5 101 17 compartments compartment NNS cord-287815-alv30uk5 101 18 , , , cord-287815-alv30uk5 101 19 compartment compartment NN cord-287815-alv30uk5 101 20 identities identity NNS cord-287815-alv30uk5 101 21 are be VBP cord-287815-alv30uk5 101 22 not not RB cord-287815-alv30uk5 101 23 static static JJ cord-287815-alv30uk5 101 24 and and CC cord-287815-alv30uk5 101 25 therefore therefore RB cord-287815-alv30uk5 101 26 may may MD cord-287815-alv30uk5 101 27 not not RB cord-287815-alv30uk5 101 28 always always RB cord-287815-alv30uk5 101 29 be be VB cord-287815-alv30uk5 101 30 entirely entirely RB cord-287815-alv30uk5 101 31 biochemically biochemically RB cord-287815-alv30uk5 101 32 distinct distinct JJ cord-287815-alv30uk5 101 33 . . . cord-287815-alv30uk5 102 1 The the DT cord-287815-alv30uk5 102 2 object object NN cord-287815-alv30uk5 102 3 , , , cord-287815-alv30uk5 102 4 then then RB cord-287815-alv30uk5 102 5 , , , cord-287815-alv30uk5 102 6 is be VBZ cord-287815-alv30uk5 102 7 to to TO cord-287815-alv30uk5 102 8 identify identify VB cord-287815-alv30uk5 102 9 only only RB cord-287815-alv30uk5 102 10 those those DT cord-287815-alv30uk5 102 11 components component NNS cord-287815-alv30uk5 102 12 that that WDT cord-287815-alv30uk5 102 13 are be VBP cord-287815-alv30uk5 102 14 endogenous endogenous JJ cord-287815-alv30uk5 102 15 , , , cord-287815-alv30uk5 102 16 i.e. i.e. FW cord-287815-alv30uk5 102 17 , , , cord-287815-alv30uk5 102 18 not not RB cord-287815-alv30uk5 102 19 involved involve VBN cord-287815-alv30uk5 102 20 in in IN cord-287815-alv30uk5 102 21 recycling recycling NN cord-287815-alv30uk5 102 22 . . . cord-287815-alv30uk5 103 1 Conceivably conceivably RB cord-287815-alv30uk5 103 2 , , , cord-287815-alv30uk5 103 3 endogenous endogenous JJ cord-287815-alv30uk5 103 4 ( ( -LRB- cord-287815-alv30uk5 103 5 or or CC cord-287815-alv30uk5 103 6 resident resident NN cord-287815-alv30uk5 103 7 ) ) -RRB- cord-287815-alv30uk5 103 8 components component NNS cord-287815-alv30uk5 103 9 may may MD cord-287815-alv30uk5 103 10 be be VB cord-287815-alv30uk5 103 11 defined define VBN cord-287815-alv30uk5 103 12 by by IN cord-287815-alv30uk5 103 13 their -PRON- PRP$ cord-287815-alv30uk5 103 14 ability ability NN cord-287815-alv30uk5 103 15 to to TO cord-287815-alv30uk5 103 16 interact interact VB cord-287815-alv30uk5 103 17 with with IN cord-287815-alv30uk5 103 18 a a DT cord-287815-alv30uk5 103 19 compartment compartment NN cord-287815-alv30uk5 103 20 - - HYPH cord-287815-alv30uk5 103 21 specific specific JJ cord-287815-alv30uk5 103 22 structural structural JJ cord-287815-alv30uk5 103 23 framework framework NN cord-287815-alv30uk5 103 24 , , , cord-287815-alv30uk5 103 25 such such JJ cord-287815-alv30uk5 103 26 as as IN cord-287815-alv30uk5 103 27 a a DT cord-287815-alv30uk5 103 28 cytosolic cytosolic JJ cord-287815-alv30uk5 103 29 membrane membrane NN cord-287815-alv30uk5 103 30 coat coat NN cord-287815-alv30uk5 103 31 or or CC cord-287815-alv30uk5 103 32 skeleton skeleton NN cord-287815-alv30uk5 103 33 . . . cord-287815-alv30uk5 104 1 It -PRON- PRP cord-287815-alv30uk5 104 2 is be VBZ cord-287815-alv30uk5 104 3 clear clear JJ cord-287815-alv30uk5 104 4 that that IN cord-287815-alv30uk5 104 5 only only RB cord-287815-alv30uk5 104 6 by by IN cord-287815-alv30uk5 104 7 identifying identify VBG cord-287815-alv30uk5 104 8 the the DT cord-287815-alv30uk5 104 9 machinery machinery NN cord-287815-alv30uk5 104 10 responsible responsible JJ cord-287815-alv30uk5 104 11 for for IN cord-287815-alv30uk5 104 12 entry entry NN cord-287815-alv30uk5 104 13 into into IN cord-287815-alv30uk5 104 14 , , , cord-287815-alv30uk5 104 15 retention retention NN cord-287815-alv30uk5 104 16 within within IN cord-287815-alv30uk5 104 17 , , , cord-287815-alv30uk5 104 18 or or CC cord-287815-alv30uk5 104 19 exit exit NN cord-287815-alv30uk5 104 20 from from IN cord-287815-alv30uk5 104 21 a a DT cord-287815-alv30uk5 104 22 compartment compartment NN cord-287815-alv30uk5 104 23 will will MD cord-287815-alv30uk5 104 24 we -PRON- PRP cord-287815-alv30uk5 104 25 be be VB cord-287815-alv30uk5 104 26 able able JJ cord-287815-alv30uk5 104 27 to to TO cord-287815-alv30uk5 104 28 precisely precisely RB cord-287815-alv30uk5 104 29 and and CC cord-287815-alv30uk5 104 30 consistently consistently RB cord-287815-alv30uk5 104 31 determine determine VB cord-287815-alv30uk5 104 32 compartment compartment NN cord-287815-alv30uk5 104 33 boundaries boundary NNS cord-287815-alv30uk5 104 34 . . . cord-287815-alv30uk5 105 1 In in IN cord-287815-alv30uk5 105 2 the the DT cord-287815-alv30uk5 105 3 absence absence NN cord-287815-alv30uk5 105 4 of of IN cord-287815-alv30uk5 105 5 this this DT cord-287815-alv30uk5 105 6 information information NN cord-287815-alv30uk5 105 7 , , , cord-287815-alv30uk5 105 8 compartments compartment NNS cord-287815-alv30uk5 105 9 can can MD cord-287815-alv30uk5 105 10 only only RB cord-287815-alv30uk5 105 11 be be VB cord-287815-alv30uk5 105 12 tentatively tentatively RB cord-287815-alv30uk5 105 13 defined define VBN cord-287815-alv30uk5 105 14 as as IN cord-287815-alv30uk5 105 15 functionally functionally RB cord-287815-alv30uk5 105 16 equivalent equivalent JJ cord-287815-alv30uk5 105 17 and and CC cord-287815-alv30uk5 105 18 possibly possibly RB cord-287815-alv30uk5 105 19 physically physically RB cord-287815-alv30uk5 105 20 continuous continuous JJ cord-287815-alv30uk5 105 21 populations population NNS cord-287815-alv30uk5 105 22 of of IN cord-287815-alv30uk5 105 23 membrane membrane NN cord-287815-alv30uk5 105 24 - - HYPH cord-287815-alv30uk5 105 25 bounded bound VBN cord-287815-alv30uk5 105 26 structures structure NNS cord-287815-alv30uk5 105 27 that that WDT cord-287815-alv30uk5 105 28 are be VBP cord-287815-alv30uk5 105 29 both both DT cord-287815-alv30uk5 105 30 functionally functionally RB cord-287815-alv30uk5 105 31 and and CC cord-287815-alv30uk5 105 32 physically physically RB cord-287815-alv30uk5 105 33 distinct distinct JJ cord-287815-alv30uk5 105 34 from from IN cord-287815-alv30uk5 105 35 all all DT cord-287815-alv30uk5 105 36 other other JJ cord-287815-alv30uk5 105 37 compartments compartment NNS cord-287815-alv30uk5 105 38 . . . cord-287815-alv30uk5 106 1 Taken take VBN cord-287815-alv30uk5 106 2 from from IN cord-287815-alv30uk5 106 3 Rambourg Rambourg NNP cord-287815-alv30uk5 106 4 and and CC cord-287815-alv30uk5 106 5 Clermont Clermont NNP cord-287815-alv30uk5 106 6 ( ( -LRB- cord-287815-alv30uk5 106 7 1990 1990 CD cord-287815-alv30uk5 106 8 ) ) -RRB- cord-287815-alv30uk5 106 9 , , , cord-287815-alv30uk5 106 10 with with IN cord-287815-alv30uk5 106 11 permission permission NN cord-287815-alv30uk5 106 12 . . . cord-287815-alv30uk5 107 1 The the DT cord-287815-alv30uk5 107 2 osmiophilic osmiophilic NNP cord-287815-alv30uk5 107 3 cis cis NNP cord-287815-alv30uk5 107 4 compartment compartment NNP cord-287815-alv30uk5 107 5 , , , cord-287815-alv30uk5 107 6 the the DT cord-287815-alv30uk5 107 7 saccules saccules NNPS cord-287815-alv30uk5 107 8 ( ( -LRB- cord-287815-alv30uk5 107 9 cisternae cisternae NNP cord-287815-alv30uk5 107 10 ) ) -RRB- cord-287815-alv30uk5 107 11 of of IN cord-287815-alv30uk5 107 12 the the DT cord-287815-alv30uk5 107 13 medial medial JJ cord-287815-alv30uk5 107 14 compartment compartment NN cord-287815-alv30uk5 107 15 , , , cord-287815-alv30uk5 107 16 as as RB cord-287815-alv30uk5 107 17 well well RB cord-287815-alv30uk5 107 18 as as IN cord-287815-alv30uk5 107 19 the the DT cord-287815-alv30uk5 107 20 cisternae cisternae NN cord-287815-alv30uk5 107 21 and and CC cord-287815-alv30uk5 107 22 tubules tubule NNS cord-287815-alv30uk5 107 23 of of IN cord-287815-alv30uk5 107 24 the the DT cord-287815-alv30uk5 107 25 trans trans NNP cord-287815-alv30uk5 107 26 compartment compartment NNP cord-287815-alv30uk5 107 27 are be VBP cord-287815-alv30uk5 107 28 all all DT cord-287815-alv30uk5 107 29 indicated indicate VBN cord-287815-alv30uk5 107 30 . . . cord-287815-alv30uk5 108 1 scribe scribe NN cord-287815-alv30uk5 108 2 definitively definitively RB cord-287815-alv30uk5 108 3 the the DT cord-287815-alv30uk5 108 4 compartmentalization compartmentalization NN cord-287815-alv30uk5 108 5 of of IN cord-287815-alv30uk5 108 6 the the DT cord-287815-alv30uk5 108 7 Golgi Golgi NNP cord-287815-alv30uk5 108 8 complex complex NN cord-287815-alv30uk5 108 9 , , , cord-287815-alv30uk5 108 10 models model NNS cord-287815-alv30uk5 108 11 for for IN cord-287815-alv30uk5 108 12 the the DT cord-287815-alv30uk5 108 13 organization organization NN cord-287815-alv30uk5 108 14 of of IN cord-287815-alv30uk5 108 15 the the DT cord-287815-alv30uk5 108 16 Golgi Golgi NNP cord-287815-alv30uk5 108 17 should should MD cord-287815-alv30uk5 108 18 be be VB cord-287815-alv30uk5 108 19 kept keep VBN cord-287815-alv30uk5 108 20 as as RB cord-287815-alv30uk5 108 21 simple simple JJ cord-287815-alv30uk5 108 22 as as IN cord-287815-alv30uk5 108 23 possible possible JJ cord-287815-alv30uk5 108 24 , , , cord-287815-alv30uk5 108 25 adding add VBG cord-287815-alv30uk5 108 26 complexity complexity NN cord-287815-alv30uk5 108 27 only only RB cord-287815-alv30uk5 108 28 as as IN cord-287815-alv30uk5 108 29 it -PRON- PRP cord-287815-alv30uk5 108 30 is be VBZ cord-287815-alv30uk5 108 31 necessitated necessitate VBN cord-287815-alv30uk5 108 32 by by IN cord-287815-alv30uk5 108 33 additional additional JJ cord-287815-alv30uk5 108 34 functional functional JJ cord-287815-alv30uk5 108 35 requirements requirement NNS cord-287815-alv30uk5 108 36 . . . cord-287815-alv30uk5 109 1 As as IN cord-287815-alv30uk5 109 2 we -PRON- PRP cord-287815-alv30uk5 109 3 have have VBP cord-287815-alv30uk5 109 4 discussed discuss VBN cord-287815-alv30uk5 109 5 , , , cord-287815-alv30uk5 109 6 there there EX cord-287815-alv30uk5 109 7 are be VBP cord-287815-alv30uk5 109 8 three three CD cord-287815-alv30uk5 109 9 minimal minimal JJ cord-287815-alv30uk5 109 10 functions function NNS cord-287815-alv30uk5 109 11 that that WDT cord-287815-alv30uk5 109 12 the the DT cord-287815-alv30uk5 109 13 Golgi Golgi NNP cord-287815-alv30uk5 109 14 must must MD cord-287815-alv30uk5 109 15 accomplish accomplish VB cord-287815-alv30uk5 109 16 : : : cord-287815-alv30uk5 109 17 first first RB cord-287815-alv30uk5 109 18 , , , cord-287815-alv30uk5 109 19 receipt receipt NN cord-287815-alv30uk5 109 20 and and CC cord-287815-alv30uk5 109 21 sorting sorting NN cord-287815-alv30uk5 109 22 of of IN cord-287815-alv30uk5 109 23 membrane membrane NN cord-287815-alv30uk5 109 24 and and CC cord-287815-alv30uk5 109 25 soluble soluble JJ cord-287815-alv30uk5 109 26 cargo cargo NN cord-287815-alv30uk5 109 27 arriving arrive VBG cord-287815-alv30uk5 109 28 at at IN cord-287815-alv30uk5 109 29 the the DT cord-287815-alv30uk5 109 30 cis cis NNP cord-287815-alv30uk5 109 31 Golgi Golgi NNP cord-287815-alv30uk5 109 32 from from IN cord-287815-alv30uk5 109 33 the the DT cord-287815-alv30uk5 109 34 ER er NN cord-287815-alv30uk5 109 35 ; ; : cord-287815-alv30uk5 109 36 second second RB cord-287815-alv30uk5 109 37 , , , cord-287815-alv30uk5 109 38 glycosylation glycosylation NN cord-287815-alv30uk5 109 39 and and CC cord-287815-alv30uk5 109 40 processing processing NN cord-287815-alv30uk5 109 41 of of IN cord-287815-alv30uk5 109 42 glycoproteins glycoprotein NNS cord-287815-alv30uk5 109 43 and and CC cord-287815-alv30uk5 109 44 glycolipids glycolipid NNS cord-287815-alv30uk5 109 45 ; ; : cord-287815-alv30uk5 109 46 and and CC cord-287815-alv30uk5 109 47 third third RB cord-287815-alv30uk5 109 48 , , , cord-287815-alv30uk5 109 49 sorting sort VBG cord-287815-alv30uk5 109 50 of of IN cord-287815-alv30uk5 109 51 membrane membrane NN cord-287815-alv30uk5 109 52 and and CC cord-287815-alv30uk5 109 53 soluble soluble JJ cord-287815-alv30uk5 109 54 cargo cargo NN cord-287815-alv30uk5 109 55 arriving arrive VBG cord-287815-alv30uk5 109 56 and and CC cord-287815-alv30uk5 109 57 exiting exit VBG cord-287815-alv30uk5 109 58 at at IN cord-287815-alv30uk5 109 59 the the DT cord-287815-alv30uk5 109 60 trans trans JJ cord-287815-alv30uk5 109 61 face face NN cord-287815-alv30uk5 109 62 of of IN cord-287815-alv30uk5 109 63 the the DT cord-287815-alv30uk5 109 64 Golgi Golgi NNP cord-287815-alv30uk5 109 65 . . . cord-287815-alv30uk5 110 1 Assuming assume VBG cord-287815-alv30uk5 110 2 that that IN cord-287815-alv30uk5 110 3 distinct distinct JJ cord-287815-alv30uk5 110 4 compartments compartment NNS cord-287815-alv30uk5 110 5 are be VBP cord-287815-alv30uk5 110 6 required require VBN cord-287815-alv30uk5 110 7 to to TO cord-287815-alv30uk5 110 8 accomplish accomplish VB cord-287815-alv30uk5 110 9 these these DT cord-287815-alv30uk5 110 10 functions function NNS cord-287815-alv30uk5 110 11 , , , cord-287815-alv30uk5 110 12 at at RB cord-287815-alv30uk5 110 13 least least RBS cord-287815-alv30uk5 110 14 three three CD cord-287815-alv30uk5 110 15 compartments compartment NNS cord-287815-alv30uk5 110 16 are be VBP cord-287815-alv30uk5 110 17 required require VBN cord-287815-alv30uk5 110 18 , , , cord-287815-alv30uk5 110 19 defined define VBN cord-287815-alv30uk5 110 20 here here RB cord-287815-alv30uk5 110 21 as as IN cord-287815-alv30uk5 110 22 the the DT cord-287815-alv30uk5 110 23 cis cis NNP cord-287815-alv30uk5 110 24 - - HYPH cord-287815-alv30uk5 110 25 Golgi Golgi NNP cord-287815-alv30uk5 110 26 network network NN cord-287815-alv30uk5 110 27 ( ( -LRB- cord-287815-alv30uk5 110 28 CGN CGN NNP cord-287815-alv30uk5 110 29 ) ) -RRB- cord-287815-alv30uk5 110 30 , , , cord-287815-alv30uk5 110 31 the the DT cord-287815-alv30uk5 110 32 medial medial JJ cord-287815-alv30uk5 110 33 Golgi Golgi NNP cord-287815-alv30uk5 110 34 , , , cord-287815-alv30uk5 110 35 and and CC cord-287815-alv30uk5 110 36 the the DT cord-287815-alv30uk5 110 37 TGN TGN NNP cord-287815-alv30uk5 110 38 , , , cord-287815-alv30uk5 110 39 respectively respectively RB cord-287815-alv30uk5 110 40 . . . cord-287815-alv30uk5 111 1 Although although IN cord-287815-alv30uk5 111 2 the the DT cord-287815-alv30uk5 111 3 details detail NNS cord-287815-alv30uk5 111 4 of of IN cord-287815-alv30uk5 111 5 Golgi Golgi NNP cord-287815-alv30uk5 111 6 morphology morphology NN cord-287815-alv30uk5 111 7 vary vary VBP cord-287815-alv30uk5 111 8 considerably considerably RB cord-287815-alv30uk5 111 9 between between IN cord-287815-alv30uk5 111 10 different different JJ cord-287815-alv30uk5 111 11 cell cell NN cord-287815-alv30uk5 111 12 types type NNS cord-287815-alv30uk5 111 13 , , , cord-287815-alv30uk5 111 14 such such PDT cord-287815-alv30uk5 111 15 a a DT cord-287815-alv30uk5 111 16 three three CD cord-287815-alv30uk5 111 17 compartment compartment NN cord-287815-alv30uk5 111 18 subdivision subdivision NN cord-287815-alv30uk5 111 19 is be VBZ cord-287815-alv30uk5 111 20 generally generally RB cord-287815-alv30uk5 111 21 consistent consistent JJ cord-287815-alv30uk5 111 22 with with IN cord-287815-alv30uk5 111 23 the the DT cord-287815-alv30uk5 111 24 overall overall JJ cord-287815-alv30uk5 111 25 structural structural JJ cord-287815-alv30uk5 111 26 organization organization NN cord-287815-alv30uk5 111 27 of of IN cord-287815-alv30uk5 111 28 the the DT cord-287815-alv30uk5 111 29 mammalian mammalian JJ cord-287815-alv30uk5 111 30 Golgi Golgi NNP cord-287815-alv30uk5 111 31 from from IN cord-287815-alv30uk5 111 32 threedimensional threedimensional JJ cord-287815-alv30uk5 111 33 reconstructions reconstruction NNS cord-287815-alv30uk5 111 34 ( ( -LRB- cord-287815-alv30uk5 111 35 Rambourg Rambourg NNP cord-287815-alv30uk5 111 36 and and CC cord-287815-alv30uk5 111 37 Clermont Clermont NNP cord-287815-alv30uk5 111 38 , , , cord-287815-alv30uk5 111 39 1990 1990 CD cord-287815-alv30uk5 111 40 ) ) -RRB- cord-287815-alv30uk5 112 1 ( ( -LRB- cord-287815-alv30uk5 112 2 Figures figure NNS cord-287815-alv30uk5 112 3 2 2 CD cord-287815-alv30uk5 112 4 and and CC cord-287815-alv30uk5 112 5 3 3 CD cord-287815-alv30uk5 112 6 ) ) -RRB- cord-287815-alv30uk5 112 7 . . . cord-287815-alv30uk5 113 1 It -PRON- PRP cord-287815-alv30uk5 113 2 is be VBZ cord-287815-alv30uk5 113 3 also also RB cord-287815-alv30uk5 113 4 consistent consistent JJ cord-287815-alv30uk5 113 5 with with IN cord-287815-alv30uk5 113 6 the the DT cord-287815-alv30uk5 113 7 functional functional JJ cord-287815-alv30uk5 113 8 organization organization NN cord-287815-alv30uk5 113 9 of of IN cord-287815-alv30uk5 113 10 the the DT cord-287815-alv30uk5 113 11 Golgi Golgi NNP cord-287815-alv30uk5 113 12 in in IN cord-287815-alv30uk5 113 13 Saccharomyces Saccharomyces NNP cord-287815-alv30uk5 113 14 cerevisiae cerevisiae NNS cord-287815-alv30uk5 113 15 , , , cord-287815-alv30uk5 113 16 which which WDT cord-287815-alv30uk5 113 17 , , , cord-287815-alv30uk5 113 18 on on IN cord-287815-alv30uk5 113 19 the the DT cord-287815-alv30uk5 113 20 basis basis NN cord-287815-alv30uk5 113 21 of of IN cord-287815-alv30uk5 113 22 mutations mutation NNS cord-287815-alv30uk5 113 23 affecting affect VBG cord-287815-alv30uk5 113 24 Golgi Golgi NNP cord-287815-alv30uk5 113 25 function function NN cord-287815-alv30uk5 113 26 , , , cord-287815-alv30uk5 113 27 has have VBZ cord-287815-alv30uk5 113 28 recently recently RB cord-287815-alv30uk5 113 29 been be VBN cord-287815-alv30uk5 113 30 proposed propose VBN cord-287815-alv30uk5 113 31 toconsist toconsist NN cord-287815-alv30uk5 113 32 of of IN cord-287815-alv30uk5 113 33 at at RB cord-287815-alv30uk5 113 34 least least RBS cord-287815-alv30uk5 113 35 three three CD cord-287815-alv30uk5 113 36 compartments compartment NNS cord-287815-alv30uk5 113 37 ( ( -LRB- cord-287815-alv30uk5 113 38 Graham Graham NNP cord-287815-alv30uk5 113 39 and and CC cord-287815-alv30uk5 113 40 Emr Emr NNP cord-287815-alv30uk5 113 41 , , , cord-287815-alv30uk5 113 42 1991 1991 CD cord-287815-alv30uk5 113 43 ) ) -RRB- cord-287815-alv30uk5 113 44 . . . cord-287815-alv30uk5 114 1 The the DT cord-287815-alv30uk5 114 2 CGN CGN NNP cord-287815-alv30uk5 115 1 At at IN cord-287815-alv30uk5 115 2 a a DT cord-287815-alv30uk5 115 3 minimum minimum NN cord-287815-alv30uk5 115 4 , , , cord-287815-alv30uk5 115 5 the the DT cord-287815-alv30uk5 115 6 cis cis NNP cord-287815-alv30uk5 115 7 side side NN cord-287815-alv30uk5 115 8 of of IN cord-287815-alv30uk5 115 9 the the DT cord-287815-alv30uk5 115 10 Golgi Golgi NNP cord-287815-alv30uk5 115 11 stack stack NN cord-287815-alv30uk5 115 12 must must MD cord-287815-alv30uk5 115 13 function function VB cord-287815-alv30uk5 115 14 in in IN cord-287815-alv30uk5 115 15 the the DT cord-287815-alv30uk5 115 16 receipt receipt NN cord-287815-alv30uk5 115 17 of of IN cord-287815-alv30uk5 115 18 newly newly RB cord-287815-alv30uk5 115 19 synthesized synthesize VBN cord-287815-alv30uk5 115 20 material material NN cord-287815-alv30uk5 115 21 from from IN cord-287815-alv30uk5 115 22 the the DT cord-287815-alv30uk5 115 23 ER ER NNP cord-287815-alv30uk5 115 24 . . . cord-287815-alv30uk5 116 1 Structurally structurally RB cord-287815-alv30uk5 116 2 , , , cord-287815-alv30uk5 116 3 however however RB cord-287815-alv30uk5 116 4 , , , cord-287815-alv30uk5 116 5 the the DT cord-287815-alv30uk5 116 6 cis cis NNP cord-287815-alv30uk5 116 7 - - HYPH cord-287815-alv30uk5 116 8 most most JJS cord-287815-alv30uk5 116 9 cisterna cisterna NNP cord-287815-alv30uk5 116 10 of of IN cord-287815-alv30uk5 116 11 the the DT cord-287815-alv30uk5 116 12 Golgi Golgi NNP cord-287815-alv30uk5 116 13 is be VBZ cord-287815-alv30uk5 116 14 typically typically RB cord-287815-alv30uk5 116 15 associated associate VBN cord-287815-alv30uk5 116 16 with with IN cord-287815-alv30uk5 116 17 a a DT cord-287815-alv30uk5 116 18 continuous continuous JJ cord-287815-alv30uk5 116 19 array array NN cord-287815-alv30uk5 116 20 of of IN cord-287815-alv30uk5 116 21 tubules tubule NNS cord-287815-alv30uk5 116 22 that that WDT cord-287815-alv30uk5 116 23 are be VBP cord-287815-alv30uk5 116 24 selectively selectively RB cord-287815-alv30uk5 116 25 stained stain VBN cord-287815-alv30uk5 116 26 after after IN cord-287815-alv30uk5 116 27 prolonged prolong VBN cord-287815-alv30uk5 116 28 osmication osmication NN cord-287815-alv30uk5 116 29 ( ( -LRB- cord-287815-alv30uk5 116 30 Lindsey Lindsey NNP cord-287815-alv30uk5 116 31 and and CC cord-287815-alv30uk5 116 32 Ellisman Ellisman NNP cord-287815-alv30uk5 116 33 , , , cord-287815-alv30uk5 116 34 1985 1985 CD cord-287815-alv30uk5 116 35 ; ; : cord-287815-alv30uk5 116 36 Rambourg Rambourg NNP cord-287815-alv30uk5 116 37 and and CC cord-287815-alv30uk5 116 38 Clermont Clermont NNP cord-287815-alv30uk5 116 39 , , , cord-287815-alv30uk5 116 40 1990 1990 CD cord-287815-alv30uk5 116 41 ) ) -RRB- cord-287815-alv30uk5 117 1 ( ( -LRB- cord-287815-alv30uk5 117 2 Figure figure NN cord-287815-alv30uk5 117 3 2 2 CD cord-287815-alv30uk5 117 4 ) ) -RRB- cord-287815-alv30uk5 117 5 . . . cord-287815-alv30uk5 118 1 Given give VBN cord-287815-alv30uk5 118 2 this this DT cord-287815-alv30uk5 118 3 distinctive distinctive JJ cord-287815-alv30uk5 118 4 morphology morphology NN cord-287815-alv30uk5 118 5 , , , cord-287815-alv30uk5 118 6 and and CC cord-287815-alv30uk5 118 7 by by IN cord-287815-alv30uk5 118 8 analogy analogy NN cord-287815-alv30uk5 118 9 to to IN cord-287815-alv30uk5 118 10 the the DT cord-287815-alv30uk5 118 11 TGN TGN NNP cord-287815-alv30uk5 118 12 , , , cord-287815-alv30uk5 118 13 it -PRON- PRP cord-287815-alv30uk5 118 14 seems seem VBZ cord-287815-alv30uk5 118 15 appropriate appropriate JJ cord-287815-alv30uk5 118 16 to to TO cord-287815-alv30uk5 118 17 refer refer VB cord-287815-alv30uk5 118 18 to to IN cord-287815-alv30uk5 118 19 this this DT cord-287815-alv30uk5 118 20 region region NN cord-287815-alv30uk5 118 21 as as IN cord-287815-alv30uk5 118 22 a a DT cord-287815-alv30uk5 118 23 distinct distinct JJ cord-287815-alv30uk5 118 24 compartment compartment NN cord-287815-alv30uk5 118 25 called call VBN cord-287815-alv30uk5 118 26 the the DT cord-287815-alv30uk5 118 27 CGN CGN NNP cord-287815-alv30uk5 118 28 ( ( -LRB- cord-287815-alv30uk5 118 29 Huttner Huttner NNP cord-287815-alv30uk5 118 30 and and CC cord-287815-alv30uk5 118 31 Tooze Tooze NNP cord-287815-alv30uk5 118 32 , , , cord-287815-alv30uk5 118 33 1989 1989 CD cord-287815-alv30uk5 118 34 ; ; : cord-287815-alv30uk5 118 35 Hsu Hsu NNP cord-287815-alv30uk5 118 36 et et NNP cord-287815-alv30uk5 118 37 al al NNP cord-287815-alv30uk5 118 38 . . NNP cord-287815-alv30uk5 118 39 , , , cord-287815-alv30uk5 118 40 1991 1991 CD cord-287815-alv30uk5 118 41 ; ; : cord-287815-alv30uk5 118 42 Pelham Pelham NNP cord-287815-alv30uk5 118 43 , , , cord-287815-alv30uk5 118 44 1991 1991 CD cord-287815-alv30uk5 118 45 ) ) -RRB- cord-287815-alv30uk5 118 46 . . . cord-287815-alv30uk5 119 1 For for IN cord-287815-alv30uk5 119 2 several several JJ cord-287815-alv30uk5 119 3 reasons reason NNS cord-287815-alv30uk5 119 4 , , , cord-287815-alv30uk5 119 5 it -PRON- PRP cord-287815-alv30uk5 119 6 also also RB cord-287815-alv30uk5 119 7 seems seem VBZ cord-287815-alv30uk5 119 8 reasonable reasonable JJ cord-287815-alv30uk5 119 9 to to TO cord-287815-alv30uk5 119 10 suggest suggest VB cord-287815-alv30uk5 119 11 that that IN cord-287815-alv30uk5 119 12 the the DT cord-287815-alv30uk5 119 13 CGN CGN NNP cord-287815-alv30uk5 119 14 also also RB cord-287815-alv30uk5 119 15 includes include VBZ cord-287815-alv30uk5 119 16 the the DT cord-287815-alv30uk5 119 17 poorly poorly RB cord-287815-alv30uk5 119 18 understood understand VBN cord-287815-alv30uk5 119 19 but but CC cord-287815-alv30uk5 119 20 possibly possibly RB cord-287815-alv30uk5 119 21 interconnected interconnected JJ cord-287815-alv30uk5 119 22 system system NN cord-287815-alv30uk5 119 23 of of IN cord-287815-alv30uk5 119 24 tubules tubule NNS cord-287815-alv30uk5 119 25 between between IN cord-287815-alv30uk5 119 26 the the DT cord-287815-alv30uk5 119 27 ER ER NNP cord-287815-alv30uk5 119 28 and and CC cord-287815-alv30uk5 119 29 the the DT cord-287815-alv30uk5 119 30 Golgi Golgi NNP cord-287815-alv30uk5 119 31 , , , cord-287815-alv30uk5 119 32 referred refer VBD cord-287815-alv30uk5 119 33 to to IN cord-287815-alv30uk5 119 34 as as IN cord-287815-alv30uk5 119 35 the the DT cord-287815-alv30uk5 119 36 " " `` cord-287815-alv30uk5 119 37 salvage salvage NN cord-287815-alv30uk5 119 38 compartment compartment NN cord-287815-alv30uk5 119 39 " " '' cord-287815-alv30uk5 119 40 ( ( -LRB- cord-287815-alv30uk5 119 41 Warren Warren NNP cord-287815-alv30uk5 119 42 , , , cord-287815-alv30uk5 119 43 1987 1987 CD cord-287815-alv30uk5 119 44 ; ; : cord-287815-alv30uk5 119 45 Pelham Pelham NNP cord-287815-alv30uk5 119 46 , , , cord-287815-alv30uk5 119 47 1991 1991 CD cord-287815-alv30uk5 119 48 ) ) -RRB- cord-287815-alv30uk5 119 49 ( ( -LRB- cord-287815-alv30uk5 119 50 Figure figure NN cord-287815-alv30uk5 119 51 3 3 CD cord-287815-alv30uk5 119 52 ) ) -RRB- cord-287815-alv30uk5 119 53 . . . cord-287815-alv30uk5 120 1 In in IN cord-287815-alv30uk5 120 2 addition addition NN cord-287815-alv30uk5 120 3 to to IN cord-287815-alv30uk5 120 4 serving serve VBG cord-287815-alv30uk5 120 5 as as IN cord-287815-alv30uk5 120 6 a a DT cord-287815-alv30uk5 120 7 site site NN cord-287815-alv30uk5 120 8 of of IN cord-287815-alv30uk5 120 9 entry entry NN cord-287815-alv30uk5 120 10 into into IN cord-287815-alv30uk5 120 11 the the DT cord-287815-alv30uk5 120 12 Golgi Golgi NNP cord-287815-alv30uk5 120 13 , , , cord-287815-alv30uk5 120 14 recent recent JJ cord-287815-alv30uk5 120 15 evidence evidence NN cord-287815-alv30uk5 120 16 suggests suggest VBZ cord-287815-alv30uk5 120 17 that that IN cord-287815-alv30uk5 120 18 the the DT cord-287815-alv30uk5 120 19 CGN CGN NNP cord-287815-alv30uk5 120 20 functions function NNS cord-287815-alv30uk5 120 21 in in IN cord-287815-alv30uk5 120 22 the the DT cord-287815-alv30uk5 120 23 recycling recycling NN cord-287815-alv30uk5 120 24 of of IN cord-287815-alv30uk5 120 25 protein protein NN cord-287815-alv30uk5 120 26 and and CC cord-287815-alv30uk5 120 27 lipid lipid NN cord-287815-alv30uk5 120 28 components component NNS cord-287815-alv30uk5 120 29 back back RB cord-287815-alv30uk5 120 30 to to IN cord-287815-alv30uk5 120 31 the the DT cord-287815-alv30uk5 120 32 ER ER NNP cord-287815-alv30uk5 120 33 , , , cord-287815-alv30uk5 120 34 while while IN cord-287815-alv30uk5 120 35 having have VBG cord-287815-alv30uk5 120 36 a a DT cord-287815-alv30uk5 120 37 relatively relatively RB cord-287815-alv30uk5 120 38 limited limited JJ cord-287815-alv30uk5 120 39 role role NN cord-287815-alv30uk5 120 40 in in IN cord-287815-alv30uk5 120 41 glycosylation glycosylation NN cord-287815-alv30uk5 120 42 . . . cord-287815-alv30uk5 121 1 Using use VBG cord-287815-alv30uk5 121 2 both both DT cord-287815-alv30uk5 121 3 animal animal NN cord-287815-alv30uk5 121 4 and and CC cord-287815-alv30uk5 121 5 yeast yeast NN cord-287815-alv30uk5 121 6 cells cell NNS cord-287815-alv30uk5 121 7 , , , cord-287815-alv30uk5 121 8 Pelham Pelham NNP cord-287815-alv30uk5 121 9 and and CC cord-287815-alv30uk5 121 10 colleagues colleague NNS cord-287815-alv30uk5 121 11 have have VBP cord-287815-alv30uk5 121 12 found find VBN cord-287815-alv30uk5 121 13 that that IN cord-287815-alv30uk5 121 14 soluble soluble JJ cord-287815-alv30uk5 121 15 ER ER NNP cord-287815-alv30uk5 121 16 proteins protein NNS cord-287815-alv30uk5 121 17 containing contain VBG cord-287815-alv30uk5 121 18 the the DT cord-287815-alv30uk5 121 19 KDEL KDEL NNP cord-287815-alv30uk5 121 20 ( ( -LRB- cord-287815-alv30uk5 121 21 or or CC cord-287815-alv30uk5 121 22 HDEL HDEL NNP cord-287815-alv30uk5 121 23 ) ) -RRB- cord-287815-alv30uk5 122 1 ER ER NNP cord-287815-alv30uk5 122 2 retention retention NN cord-287815-alv30uk5 122 3 marker marker NN cord-287815-alv30uk5 122 4 are be VBP cord-287815-alv30uk5 122 5 delivered deliver VBN cord-287815-alv30uk5 122 6 to to IN cord-287815-alv30uk5 122 7 a a DT cord-287815-alv30uk5 122 8 post post NN cord-287815-alv30uk5 122 9 - - JJ cord-287815-alv30uk5 122 10 ER er NN cord-287815-alv30uk5 123 1 The the DT cord-287815-alv30uk5 123 2 ports port NNS cord-287815-alv30uk5 123 3 of of IN cord-287815-alv30uk5 123 4 exit exit NN cord-287815-alv30uk5 123 5 are be VBP cord-287815-alv30uk5 123 6 the the DT cord-287815-alv30uk5 123 7 sites site NNS cord-287815-alv30uk5 123 8 from from IN cord-287815-alv30uk5 123 9 which which WDT cord-287815-alv30uk5 123 10 proteins protein NNS cord-287815-alv30uk5 123 11 leave leave VBP cord-287815-alv30uk5 123 12 the the DT cord-287815-alv30uk5 123 13 ER er NN cord-287815-alv30uk5 123 14 . . . cord-287815-alv30uk5 124 1 As as IN cord-287815-alv30uk5 124 2 discussed discuss VBN cord-287815-alv30uk5 124 3 in in IN cord-287815-alv30uk5 124 4 the the DT cord-287815-alv30uk5 124 5 text text NN cord-287815-alv30uk5 124 6 , , , cord-287815-alv30uk5 124 7 the the DT cord-287815-alv30uk5 124 8 " " `` cord-287815-alv30uk5 124 9 intermediate intermediate JJ cord-287815-alv30uk5 124 10 compartment compartment NN cord-287815-alv30uk5 124 11 " " '' cord-287815-alv30uk5 124 12 defined define VBN cord-287815-alv30uk5 124 13 by by IN cord-287815-alv30uk5 124 14 the the DT cord-287815-alv30uk5 124 15 p53 p53 NN cord-287815-alv30uk5 124 16 and and CC cord-287815-alv30uk5 124 17 ~58 ~58 NFP cord-287815-alv30uk5 124 18 antigens antigen NNS cord-287815-alv30uk5 124 19 probably probably RB cord-287815-alv30uk5 124 20 consists consist VBZ cord-287815-alv30uk5 124 21 both both DT cord-287815-alv30uk5 124 22 of of IN cord-287815-alv30uk5 124 23 the the DT cord-287815-alv30uk5 124 24 CGN CGN NNP cord-287815-alv30uk5 124 25 , , , cord-287815-alv30uk5 124 26 the the DT cord-287815-alv30uk5 124 27 ports port NNS cord-287815-alv30uk5 124 28 of of IN cord-287815-alv30uk5 124 29 exit exit NN cord-287815-alv30uk5 124 30 from from IN cord-287815-alv30uk5 124 31 the the DT cord-287815-alv30uk5 124 32 ER ER NNP cord-287815-alv30uk5 124 33 , , , cord-287815-alv30uk5 124 34 and and CC cord-287815-alv30uk5 124 35 the the DT cord-287815-alv30uk5 124 36 carrier carrier NN cord-287815-alv30uk5 124 37 elements element NNS cord-287815-alv30uk5 124 38 responsible responsible JJ cord-287815-alv30uk5 124 39 for for IN cord-287815-alv30uk5 124 40 bidirectional bidirectional JJ cord-287815-alv30uk5 124 41 transport transport NN cord-287815-alv30uk5 124 42 between between IN cord-287815-alv30uk5 124 43 the the DT cord-287815-alv30uk5 124 44 ER ER NNP cord-287815-alv30uk5 124 45 and and CC cord-287815-alv30uk5 124 46 the the DT cord-287815-alv30uk5 124 47 CGN CGN NNP cord-287815-alv30uk5 124 48 . . . cord-287815-alv30uk5 125 1 The the DT cord-287815-alv30uk5 125 2 lateral lateral JJ cord-287815-alv30uk5 125 3 arrows arrow NNS cord-287815-alv30uk5 125 4 would would MD cord-287815-alv30uk5 125 5 be be VB cord-287815-alv30uk5 125 6 sites site NNS cord-287815-alv30uk5 125 7 where where WRB cord-287815-alv30uk5 125 8 direct direct JJ cord-287815-alv30uk5 125 9 fusions fusion NNS cord-287815-alv30uk5 125 10 would would MD cord-287815-alv30uk5 125 11 interconnect interconnect VB cord-287815-alv30uk5 125 12 CGN CGN NNP cord-287815-alv30uk5 125 13 - - HYPH cord-287815-alv30uk5 125 14 CGN CGN NNP cord-287815-alv30uk5 125 15 , , , cord-287815-alv30uk5 125 16 medialmedial medialmedial JJ cord-287815-alv30uk5 125 17 , , , cord-287815-alv30uk5 125 18 and and CC cord-287815-alv30uk5 125 19 TGN TGN NNP cord-287815-alv30uk5 125 20 - - HYPH cord-287815-alv30uk5 125 21 TGN TGN NNP cord-287815-alv30uk5 125 22 compartments compartment NNS cord-287815-alv30uk5 125 23 of of IN cord-287815-alv30uk5 125 24 two two CD cord-287815-alv30uk5 125 25 adjacent adjacent JJ cord-287815-alv30uk5 125 26 stacks stack NNS cord-287815-alv30uk5 125 27 . . . cord-287815-alv30uk5 126 1 Compare compare VB cord-287815-alv30uk5 126 2 these these DT cord-287815-alv30uk5 126 3 sites site NNS cord-287815-alv30uk5 126 4 to to IN cord-287815-alv30uk5 126 5 the the DT cord-287815-alv30uk5 126 6 discontinuities discontinuity NNS cord-287815-alv30uk5 126 7 in in IN cord-287815-alv30uk5 126 8 Figure figure NN cord-287815-alv30uk5 126 9 1 1 CD cord-287815-alv30uk5 126 10 . . . cord-287815-alv30uk5 127 1 site site NN cord-287815-alv30uk5 127 2 , , , cord-287815-alv30uk5 127 3 in in IN cord-287815-alv30uk5 127 4 which which WDT cord-287815-alv30uk5 127 5 little little JJ cord-287815-alv30uk5 127 6 " " `` cord-287815-alv30uk5 127 7 Golgi golgi NN cord-287815-alv30uk5 127 8 - - HYPH cord-287815-alv30uk5 127 9 like like JJ cord-287815-alv30uk5 127 10 " " '' cord-287815-alv30uk5 127 11 oligosaccharide oligosaccharide NN cord-287815-alv30uk5 127 12 processing processing NN cord-287815-alv30uk5 127 13 oiccurs oiccur NNS cord-287815-alv30uk5 127 14 and and CC cord-287815-alv30uk5 127 15 from from IN cord-287815-alv30uk5 127 16 which which WDT cord-287815-alv30uk5 127 17 these these DT cord-287815-alv30uk5 127 18 proteins protein NNS cord-287815-alv30uk5 127 19 are be VBP cord-287815-alv30uk5 127 20 returned return VBN cord-287815-alv30uk5 127 21 to to IN cord-287815-alv30uk5 127 22 the the DT cord-287815-alv30uk5 127 23 ER ER NNP cord-287815-alv30uk5 127 24 ( ( -LRB- cord-287815-alv30uk5 127 25 Pelham Pelham NNP cord-287815-alv30uk5 127 26 , , , cord-287815-alv30uk5 127 27 1988 1988 CD cord-287815-alv30uk5 127 28 ( ( -LRB- cord-287815-alv30uk5 127 29 Pelham Pelham NNP cord-287815-alv30uk5 127 30 , , , cord-287815-alv30uk5 127 31 , , , cord-287815-alv30uk5 127 32 1989 1989 CD cord-287815-alv30uk5 127 33 Dean Dean NNP cord-287815-alv30uk5 127 34 and and CC cord-287815-alv30uk5 127 35 Pelham Pelham NNP cord-287815-alv30uk5 127 36 , , , cord-287815-alv30uk5 127 37 1990 1990 CD cord-287815-alv30uk5 127 38 ) ) -RRB- cord-287815-alv30uk5 127 39 . . . cord-287815-alv30uk5 128 1 In in IN cord-287815-alv30uk5 128 2 animal animal NN cord-287815-alv30uk5 128 3 cells cell NNS cord-287815-alv30uk5 128 4 , , , cord-287815-alv30uk5 128 5 the the DT cord-287815-alv30uk5 128 6 lysosomal lysosomal JJ cord-287815-alv30uk5 128 7 enzyme enzyme NN cord-287815-alv30uk5 128 8 cathepsin cathepsin NN cord-287815-alv30uk5 128 9 D D NNP cord-287815-alv30uk5 128 10 was be VBD cord-287815-alv30uk5 128 11 given give VBN cord-287815-alv30uk5 128 12 a a DT cord-287815-alv30uk5 128 13 C c NN cord-287815-alv30uk5 128 14 - - HYPH cord-287815-alv30uk5 128 15 terminal terminal NN cord-287815-alv30uk5 128 16 KDEL KDEL NNP cord-287815-alv30uk5 128 17 tag tag NN cord-287815-alv30uk5 128 18 and and CC cord-287815-alv30uk5 128 19 found find VBD cord-287815-alv30uk5 128 20 not not RB cord-287815-alv30uk5 128 21 to to TO cord-287815-alv30uk5 128 22 receive receive VB cord-287815-alv30uk5 128 23 any any DT cord-287815-alv30uk5 128 24 terminal terminal JJ cord-287815-alv30uk5 128 25 sugar sugar NN cord-287815-alv30uk5 128 26 modifications modification NNS cord-287815-alv30uk5 128 27 associated associate VBN cord-287815-alv30uk5 128 28 with with IN cord-287815-alv30uk5 128 29 Golgi Golgi NNP cord-287815-alv30uk5 128 30 - - HYPH cord-287815-alv30uk5 128 31 linked link VBN cord-287815-alv30uk5 128 32 glycosylation glycosylation NN cord-287815-alv30uk5 128 33 . . . cord-287815-alv30uk5 129 1 However however RB cord-287815-alv30uk5 129 2 , , , cord-287815-alv30uk5 129 3 mannose mannose NN cord-287815-alv30uk5 129 4 residues residue NNS cord-287815-alv30uk5 129 5 on on IN cord-287815-alv30uk5 129 6 the the DT cord-287815-alv30uk5 129 7 enzyme enzyme NN cord-287815-alv30uk5 129 8 did do VBD cord-287815-alv30uk5 129 9 receive receive VB cord-287815-alv30uk5 129 10 a a DT cord-287815-alv30uk5 129 11 GlcNAc glcnac NN cord-287815-alv30uk5 129 12 - - HYPH cord-287815-alv30uk5 129 13 phosphate phosphate NN cord-287815-alv30uk5 129 14 . . . cord-287815-alv30uk5 130 1 Thus thus RB cord-287815-alv30uk5 130 2 , , , cord-287815-alv30uk5 130 3 although although IN cord-287815-alv30uk5 130 4 the the DT cord-287815-alv30uk5 130 5 KDEL KDEL NNP cord-287815-alv30uk5 130 6 clonstruct clonstruct NNS cord-287815-alv30uk5 130 7 reached reach VBD cord-287815-alv30uk5 130 8 a a DT cord-287815-alv30uk5 130 9 GlcNAc GlcNAc NNP cord-287815-alv30uk5 130 10 - - HYPH cord-287815-alv30uk5 130 11 phosphotransferase phosphotransferase NN cord-287815-alv30uk5 130 12 - - HYPH cord-287815-alv30uk5 130 13 containing contain VBG cord-287815-alv30uk5 130 14 compartment compartment NN cord-287815-alv30uk5 130 15 , , , cord-287815-alv30uk5 130 16 it -PRON- PRP cord-287815-alv30uk5 130 17 did do VBD cord-287815-alv30uk5 130 18 not not RB cord-287815-alv30uk5 130 19 encounter encounter VB cord-287815-alv30uk5 130 20 mannosidase mannosidase NN cord-287815-alv30uk5 130 21 I -PRON- PRP cord-287815-alv30uk5 130 22 , , , cord-287815-alv30uk5 130 23 a a DT cord-287815-alv30uk5 130 24 glycosidase glycosidase NN cord-287815-alv30uk5 130 25 that that WDT cord-287815-alv30uk5 130 26 would would MD cord-287815-alv30uk5 130 27 remove remove VB cord-287815-alv30uk5 130 28 the the DT cord-287815-alv30uk5 130 29 phosphotransferase phosphotransferase NN cord-287815-alv30uk5 130 30 substrate substrate NN cord-287815-alv30uk5 130 31 . . . cord-287815-alv30uk5 131 1 Although although IN cord-287815-alv30uk5 131 2 it -PRON- PRP cord-287815-alv30uk5 131 3 may may MD cord-287815-alv30uk5 131 4 yet yet RB cord-287815-alv30uk5 131 5 turn turn VB cord-287815-alv30uk5 131 6 out out RP cord-287815-alv30uk5 131 7 that that IN cord-287815-alv30uk5 131 8 some some DT cord-287815-alv30uk5 131 9 KDEL KDEL NNP cord-287815-alv30uk5 131 10 proteins protein NNS cord-287815-alv30uk5 131 11 receive receive VBP cord-287815-alv30uk5 131 12 further further JJ cord-287815-alv30uk5 131 13 oligosaccharide oligosaccharide NN cord-287815-alv30uk5 131 14 modifications modification NNS cord-287815-alv30uk5 131 15 , , , cord-287815-alv30uk5 131 16 K.DEL k.del NN cord-287815-alv30uk5 131 17 receptors receptor NNS cord-287815-alv30uk5 131 18 can can MD cord-287815-alv30uk5 131 19 retrieve retrieve VB cord-287815-alv30uk5 131 20 these these DT cord-287815-alv30uk5 131 21 proteins protein NNS cord-287815-alv30uk5 131 22 before before IN cord-287815-alv30uk5 131 23 they -PRON- PRP cord-287815-alv30uk5 131 24 reach reach VBP cord-287815-alv30uk5 131 25 the the DT cord-287815-alv30uk5 131 26 bulk bulk NN cord-287815-alv30uk5 131 27 of of IN cord-287815-alv30uk5 131 28 the the DT cord-287815-alv30uk5 131 29 oligosaccharide oligosaccharide NN cord-287815-alv30uk5 131 30 transferases transferase NNS cord-287815-alv30uk5 131 31 ; ; : cord-287815-alv30uk5 131 32 thus thus RB cord-287815-alv30uk5 131 33 , , , cord-287815-alv30uk5 131 34 recycling recycling NN cord-287815-alv30uk5 131 35 is be VBZ cord-287815-alv30uk5 131 36 a a DT cord-287815-alv30uk5 131 37 function function NN cord-287815-alv30uk5 131 38 associated associate VBN cord-287815-alv30uk5 131 39 with with IN cord-287815-alv30uk5 131 40 a a DT cord-287815-alv30uk5 131 41 distinct distinct JJ cord-287815-alv30uk5 131 42 " " `` cord-287815-alv30uk5 131 43 early early JJ cord-287815-alv30uk5 131 44 " " '' cord-287815-alv30uk5 131 45 Golgi Golgi NNP cord-287815-alv30uk5 131 46 compartment compartment NN cord-287815-alv30uk5 131 47 . . . cord-287815-alv30uk5 132 1 Without without IN cord-287815-alv30uk5 132 2 immunocytochemical immunocytochemical JJ cord-287815-alv30uk5 132 3 localization localization NN cord-287815-alv30uk5 132 4 of of IN cord-287815-alv30uk5 132 5 these these DT cord-287815-alv30uk5 132 6 constructs construct NNS cord-287815-alv30uk5 132 7 ( ( -LRB- cord-287815-alv30uk5 132 8 the the DT cord-287815-alv30uk5 132 9 KDEL KDEL NNP cord-287815-alv30uk5 132 10 receptor receptor NN cord-287815-alv30uk5 132 11 or or CC cord-287815-alv30uk5 132 12 the the DT cord-287815-alv30uk5 132 13 phosphotransferase phosphotransferase NN cord-287815-alv30uk5 132 14 ) ) -RRB- cord-287815-alv30uk5 132 15 , , , cord-287815-alv30uk5 132 16 it -PRON- PRP cord-287815-alv30uk5 132 17 is be VBZ cord-287815-alv30uk5 132 18 impossible impossible JJ cord-287815-alv30uk5 132 19 to to TO cord-287815-alv30uk5 132 20 be be VB cord-287815-alv30uk5 132 21 certain certain JJ cord-287815-alv30uk5 132 22 that that IN cord-287815-alv30uk5 132 23 these these DT cord-287815-alv30uk5 132 24 events event NNS cord-287815-alv30uk5 132 25 occur occur VBP cord-287815-alv30uk5 132 26 in in IN cord-287815-alv30uk5 132 27 the the DT cord-287815-alv30uk5 132 28 CGN CGN NNP cord-287815-alv30uk5 132 29 . . . cord-287815-alv30uk5 133 1 However however RB cord-287815-alv30uk5 133 2 , , , cord-287815-alv30uk5 133 3 this this DT cord-287815-alv30uk5 133 4 appears appear VBZ cord-287815-alv30uk5 133 5 likely likely RB cord-287815-alv30uk5 133 6 , , , cord-287815-alv30uk5 133 7 given give VBN cord-287815-alv30uk5 133 8 that that IN cord-287815-alv30uk5 133 9 our -PRON- PRP$ cord-287815-alv30uk5 133 10 model model NN cord-287815-alv30uk5 133 11 assumes assume VBZ cord-287815-alv30uk5 133 12 that that IN cord-287815-alv30uk5 133 13 the the DT cord-287815-alv30uk5 133 14 tubules tubule NNS cord-287815-alv30uk5 133 15 and and CC cord-287815-alv30uk5 133 16 vesicles vesicle NNS cord-287815-alv30uk5 133 17 defining define VBG cord-287815-alv30uk5 133 18 the the DT cord-287815-alv30uk5 133 19 CGN CGN NNP cord-287815-alv30uk5 133 20 are be VBP cord-287815-alv30uk5 133 21 also also RB cord-287815-alv30uk5 133 22 associated associate VBN cord-287815-alv30uk5 133 23 with with IN cord-287815-alv30uk5 133 24 antigens antigen NNS cord-287815-alv30uk5 133 25 such such JJ cord-287815-alv30uk5 133 26 as as IN cord-287815-alv30uk5 133 27 ~53 ~53 CD cord-287815-alv30uk5 133 28 , , , cord-287815-alv30uk5 133 29 ~58 ~58 XX cord-287815-alv30uk5 133 30 , , , cord-287815-alv30uk5 133 31 and and CC cord-287815-alv30uk5 133 32 mb2 mb2 NNP cord-287815-alv30uk5 133 33 ( ( -LRB- cord-287815-alv30uk5 133 34 Saraste Saraste NNP cord-287815-alv30uk5 133 35 et et NNP cord-287815-alv30uk5 133 36 al al NNP cord-287815-alv30uk5 133 37 . . NNP cord-287815-alv30uk5 133 38 , , , cord-287815-alv30uk5 133 39 1987 1987 CD cord-287815-alv30uk5 133 40 ; ; : cord-287815-alv30uk5 133 41 Schweizer Schweizer NNP cord-287815-alv30uk5 133 42 et et NNP cord-287815-alv30uk5 133 43 al al NNP cord-287815-alv30uk5 133 44 . . NNP cord-287815-alv30uk5 133 45 , , , cord-287815-alv30uk5 133 46 1988 1988 CD cord-287815-alv30uk5 133 47 ; ; : cord-287815-alv30uk5 133 48 Chavrier Chavrier NNP cord-287815-alv30uk5 133 49 et et NNP cord-287815-alv30uk5 133 50 al al NNP cord-287815-alv30uk5 133 51 . . NNP cord-287815-alv30uk5 133 52 , , , cord-287815-alv30uk5 133 53 1990 1990 CD cord-287815-alv30uk5 133 54 ) ) -RRB- cord-287815-alv30uk5 133 55 which which WDT cord-287815-alv30uk5 133 56 have have VBP cord-287815-alv30uk5 133 57 been be VBN cord-287815-alv30uk5 133 58 used use VBN cord-287815-alv30uk5 133 59 to to TO cord-287815-alv30uk5 133 60 define define VB cord-287815-alv30uk5 133 61 the the DT cord-287815-alv30uk5 133 62 so so RB cord-287815-alv30uk5 133 63 - - HYPH cord-287815-alv30uk5 133 64 called call VBN cord-287815-alv30uk5 133 65 " " `` cord-287815-alv30uk5 133 66 intermediate intermediate JJ cord-287815-alv30uk5 133 67 compartment compartment NN cord-287815-alv30uk5 133 68 " " '' cord-287815-alv30uk5 133 69 . . . cord-287815-alv30uk5 134 1 These these DT cord-287815-alv30uk5 134 2 antigens antigen NNS cord-287815-alv30uk5 134 3 label label NN cord-287815-alv30uk5 134 4 structures structure NNS cord-287815-alv30uk5 134 5 that that WDT cord-287815-alv30uk5 134 6 appear appear VBP cord-287815-alv30uk5 134 7 to to TO cord-287815-alv30uk5 134 8 serve serve VB cord-287815-alv30uk5 134 9 as as IN cord-287815-alv30uk5 134 10 intermediates intermediate NNS cord-287815-alv30uk5 134 11 in in IN cord-287815-alv30uk5 134 12 transport transport NN cord-287815-alv30uk5 134 13 from from IN cord-287815-alv30uk5 134 14 the the DT cord-287815-alv30uk5 134 15 ER ER NNP cord-287815-alv30uk5 134 16 to to IN cord-287815-alv30uk5 134 17 the the DT cord-287815-alv30uk5 134 18 Golgi Golgi NNP cord-287815-alv30uk5 134 19 as as RB cord-287815-alv30uk5 134 20 well well RB cord-287815-alv30uk5 134 21 a.s a.s NNP cord-287815-alv30uk5 134 22 in in IN cord-287815-alv30uk5 134 23 the the DT cord-287815-alv30uk5 134 24 recycling recycling NN cord-287815-alv30uk5 134 25 of of IN cord-287815-alv30uk5 134 26 Golgi Golgi NNP cord-287815-alv30uk5 134 27 components component NNS cord-287815-alv30uk5 134 28 back back RB cord-287815-alv30uk5 134 29 to to IN cord-287815-alv30uk5 134 30 the the DT cord-287815-alv30uk5 134 31 ER er NN cord-287815-alv30uk5 135 1 ( ( -LRB- cord-287815-alv30uk5 135 2 I i NN cord-287815-alv30uk5 135 3 - - HYPH cord-287815-alv30uk5 135 4 ippincott- ippincott- NN cord-287815-alv30uk5 135 5 Schwartz Schwartz NNP cord-287815-alv30uk5 135 6 et et NNP cord-287815-alv30uk5 135 7 al al NNP cord-287815-alv30uk5 135 8 . . NNP cord-287815-alv30uk5 135 9 , , , cord-287815-alv30uk5 135 10 1990 1990 CD cord-287815-alv30uk5 135 11 ) ) -RRB- cord-287815-alv30uk5 135 12 . . . cord-287815-alv30uk5 136 1 The the DT cord-287815-alv30uk5 136 2 markers marker NNS cord-287815-alv30uk5 136 3 also also RB cord-287815-alv30uk5 136 4 label label VBP cord-287815-alv30uk5 136 5 presumed presume VBN cord-287815-alv30uk5 136 6 sites site NNS cord-287815-alv30uk5 136 7 of of IN cord-287815-alv30uk5 136 8 exit exit NN cord-287815-alv30uk5 136 9 from from IN cord-287815-alv30uk5 136 10 the the DT cord-287815-alv30uk5 136 11 ER er NN cord-287815-alv30uk5 136 12 ( ( -LRB- cord-287815-alv30uk5 136 13 " " `` cord-287815-alv30uk5 136 14 transitional transitional JJ cord-287815-alv30uk5 136 15 elements element NNS cord-287815-alv30uk5 136 16 , , , cord-287815-alv30uk5 136 17 " " `` cord-287815-alv30uk5 136 18 Palade Palade NNP cord-287815-alv30uk5 136 19 , , , cord-287815-alv30uk5 136 20 1975 1975 CD cord-287815-alv30uk5 136 21 ) ) -RRB- cord-287815-alv30uk5 136 22 as as RB cord-287815-alv30uk5 136 23 well well RB cord-287815-alv30uk5 136 24 as as IN cord-287815-alv30uk5 136 25 the the DT cord-287815-alv30uk5 136 26 cis cis NNP cord-287815-alv30uk5 136 27 - - HYPH cord-287815-alv30uk5 136 28 most most JJS cord-287815-alv30uk5 136 29 Golgi Golgi NNP cord-287815-alv30uk5 136 30 cisterna cisterna NN cord-287815-alv30uk5 136 31 ( ( -LRB- cord-287815-alv30uk5 136 32 Saraste Saraste NNP cord-287815-alv30uk5 136 33 and and CC cord-287815-alv30uk5 136 34 Svensson Svensson NNP cord-287815-alv30uk5 136 35 , , , cord-287815-alv30uk5 136 36 1991 1991 CD cord-287815-alv30uk5 136 37 ; ; : cord-287815-alv30uk5 136 38 Lotti Lotti NNP cord-287815-alv30uk5 136 39 et et NNP cord-287815-alv30uk5 136 40 al al NNP cord-287815-alv30uk5 136 41 . . NNP cord-287815-alv30uk5 136 42 , , , cord-287815-alv30uk5 136 43 1992 1992 CD cord-287815-alv30uk5 136 44 ) ) -RRB- cord-287815-alv30uk5 136 45 , , , cord-287815-alv30uk5 136 46 suggesting suggest VBG cord-287815-alv30uk5 136 47 that that IN cord-287815-alv30uk5 136 48 they -PRON- PRP cord-287815-alv30uk5 136 49 are be VBP cord-287815-alv30uk5 136 50 not not RB cord-287815-alv30uk5 136 51 endogenous endogenous JJ cord-287815-alv30uk5 136 52 CGN CGN NNP cord-287815-alv30uk5 136 53 components component NNS cord-287815-alv30uk5 136 54 , , , cord-287815-alv30uk5 136 55 but but CC cord-287815-alv30uk5 136 56 recycle recycle VB cord-287815-alv30uk5 136 57 between between IN cord-287815-alv30uk5 136 58 the the DT cord-287815-alv30uk5 136 59 ER ER NNP cord-287815-alv30uk5 136 60 and and CC cord-287815-alv30uk5 136 61 CGN CGN NNP cord-287815-alv30uk5 136 62 . . . cord-287815-alv30uk5 137 1 Thus thus RB cord-287815-alv30uk5 137 2 , , , cord-287815-alv30uk5 137 3 the the DT cord-287815-alv30uk5 137 4 intermediate intermediate JJ cord-287815-alv30uk5 137 5 compartment compartment NN cord-287815-alv30uk5 137 6 probably probably RB cord-287815-alv30uk5 137 7 comprises comprise VBZ cord-287815-alv30uk5 137 8 the the DT cord-287815-alv30uk5 137 9 exit exit NN cord-287815-alv30uk5 137 10 sites site NNS cord-287815-alv30uk5 137 11 from from IN cord-287815-alv30uk5 137 12 both both CC cord-287815-alv30uk5 137 13 the the DT cord-287815-alv30uk5 137 14 E.R E.R NNS cord-287815-alv30uk5 137 15 and and CC cord-287815-alv30uk5 137 16 the the DT cord-287815-alv30uk5 137 17 CGN CGN NNP cord-287815-alv30uk5 137 18 as as RB cord-287815-alv30uk5 137 19 well well RB cord-287815-alv30uk5 137 20 as as IN cord-287815-alv30uk5 137 21 the the DT cord-287815-alv30uk5 137 22 dynamic dynamic JJ cord-287815-alv30uk5 137 23 " " `` cord-287815-alv30uk5 137 24 pool pool NN cord-287815-alv30uk5 137 25 " " '' cord-287815-alv30uk5 137 26 of of IN cord-287815-alv30uk5 137 27 vesicles vesicle NNS cord-287815-alv30uk5 137 28 and and CC cord-287815-alv30uk5 137 29 tubules tubule NNS cord-287815-alv30uk5 137 30 that that WDT cord-287815-alv30uk5 137 31 reflects reflect VBZ cord-287815-alv30uk5 137 32 the the DT cord-287815-alv30uk5 137 33 continuous continuous JJ cord-287815-alv30uk5 137 34 recycling recycling NN cord-287815-alv30uk5 137 35 between between IN cord-287815-alv30uk5 137 36 tlhe tlhe NNP cord-287815-alv30uk5 137 37 two two CD cord-287815-alv30uk5 137 38 sites site NNS cord-287815-alv30uk5 137 39 ( ( -LRB- cord-287815-alv30uk5 137 40 Figure figure NN cord-287815-alv30uk5 137 41 3 3 CD cord-287815-alv30uk5 137 42 ) ) -RRB- cord-287815-alv30uk5 137 43 . . . cord-287815-alv30uk5 138 1 Although although IN cord-287815-alv30uk5 138 2 incubation incubation NN cord-287815-alv30uk5 138 3 at at IN cord-287815-alv30uk5 138 4 low low JJ cord-287815-alv30uk5 138 5 temperalture temperalture NN cord-287815-alv30uk5 138 6 has have VBZ cord-287815-alv30uk5 138 7 also also RB cord-287815-alv30uk5 138 8 been be VBN cord-287815-alv30uk5 138 9 used use VBN cord-287815-alv30uk5 138 10 to to TO cord-287815-alv30uk5 138 11 delineate delineate VB cord-287815-alv30uk5 138 12 boundaries boundary NNS cord-287815-alv30uk5 138 13 in in IN cord-287815-alv30uk5 138 14 this this DT cord-287815-alv30uk5 138 15 region region NN cord-287815-alv30uk5 138 16 , , , cord-287815-alv30uk5 138 17 like like IN cord-287815-alv30uk5 138 18 all all DT cord-287815-alv30uk5 138 19 temperature temperature NN cord-287815-alv30uk5 138 20 blocks block NNS cord-287815-alv30uk5 138 21 , , , cord-287815-alv30uk5 138 22 forward forward JJ cord-287815-alv30uk5 138 23 transport transport NN cord-287815-alv30uk5 138 24 is be VBZ cord-287815-alv30uk5 138 25 clependent clependent VBN cord-287815-alv30uk5 138 26 on on IN cord-287815-alv30uk5 138 27 length length NN cord-287815-alv30uk5 138 28 of of IN cord-287815-alv30uk5 138 29 incubation incubation NN cord-287815-alv30uk5 138 30 , , , cord-287815-alv30uk5 138 31 making make VBG cord-287815-alv30uk5 138 32 precise precise JJ cord-287815-alv30uk5 138 33 interpretation interpretation NN cord-287815-alv30uk5 138 34 even even RB cord-287815-alv30uk5 138 35 more more RBR cord-287815-alv30uk5 138 36 difficult difficult JJ cord-287815-alv30uk5 138 37 than than IN cord-287815-alv30uk5 138 38 usual usual JJ cord-287815-alv30uk5 138 39 . . . cord-287815-alv30uk5 139 1 We -PRON- PRP cord-287815-alv30uk5 139 2 thus thus RB cord-287815-alv30uk5 139 3 view view VBP cord-287815-alv30uk5 139 4 the the DT cord-287815-alv30uk5 139 5 CGN CGN NNP cord-287815-alv30uk5 139 6 as as IN cord-287815-alv30uk5 139 7 a a DT cord-287815-alv30uk5 139 8 unique unique JJ cord-287815-alv30uk5 139 9 Golgi Golgi NNP cord-287815-alv30uk5 139 10 compartment compartment NN cord-287815-alv30uk5 139 11 responsible responsible JJ cord-287815-alv30uk5 139 12 for for IN cord-287815-alv30uk5 139 13 receiving receive VBG cord-287815-alv30uk5 139 14 and and CC cord-287815-alv30uk5 139 15 sorting sort VBG cord-287815-alv30uk5 139 16 components component NNS cord-287815-alv30uk5 139 17 arriving arrive VBG cord-287815-alv30uk5 139 18 from from IN cord-287815-alv30uk5 139 19 the the DT cord-287815-alv30uk5 139 20 ER ER NNP cord-287815-alv30uk5 139 21 . . . cord-287815-alv30uk5 140 1 Structurally structurally RB cord-287815-alv30uk5 140 2 , , , cord-287815-alv30uk5 140 3 we -PRON- PRP cord-287815-alv30uk5 140 4 predict predict VBP cord-287815-alv30uk5 140 5 it -PRON- PRP cord-287815-alv30uk5 140 6 will will MD cord-287815-alv30uk5 140 7 ordinarily ordinarily RB cord-287815-alv30uk5 140 8 ( ( -LRB- cord-287815-alv30uk5 140 9 but but CC cord-287815-alv30uk5 140 10 perhaps perhaps RB cord-287815-alv30uk5 140 11 not not RB cord-287815-alv30uk5 140 12 always always RB cord-287815-alv30uk5 140 13 ) ) -RRB- cord-287815-alv30uk5 140 14 consist consist VBP cord-287815-alv30uk5 140 15 of of IN cord-287815-alv30uk5 140 16 the the DT cord-287815-alv30uk5 140 17 cis cis NNP cord-287815-alv30uk5 140 18 - - HYPH cord-287815-alv30uk5 140 19 most most JJS cord-287815-alv30uk5 140 20 Golgi Golgi NNP cord-287815-alv30uk5 140 21 cisterna cisterna NNP cord-287815-alv30uk5 140 22 and and CC cord-287815-alv30uk5 140 23 the the DT cord-287815-alv30uk5 140 24 associated associate VBN cord-287815-alv30uk5 140 25 vesicles vesicle NNS cord-287815-alv30uk5 140 26 and and CC cord-287815-alv30uk5 140 27 tubules tubule NNS cord-287815-alv30uk5 140 28 that that WDT cord-287815-alv30uk5 140 29 include include VBP cord-287815-alv30uk5 140 30 the the DT cord-287815-alv30uk5 140 31 intermediate intermediate JJ cord-287815-alv30uk5 140 32 compartment compartment NN cord-287815-alv30uk5 140 33 of of IN cord-287815-alv30uk5 140 34 Schweizer Schweizer NNP cord-287815-alv30uk5 140 35 et et NNP cord-287815-alv30uk5 140 36 al al NNP cord-287815-alv30uk5 140 37 . . . cord-287815-alv30uk5 141 1 ( ( -LRB- cord-287815-alv30uk5 141 2 1990 1990 CD cord-287815-alv30uk5 141 3 ) ) -RRB- cord-287815-alv30uk5 141 4 . . . cord-287815-alv30uk5 142 1 In in IN cord-287815-alv30uk5 142 2 addition addition NN cord-287815-alv30uk5 142 3 to to IN cord-287815-alv30uk5 142 4 the the DT cord-287815-alv30uk5 142 5 transport transport NN cord-287815-alv30uk5 142 6 of of IN cord-287815-alv30uk5 142 7 KDEL KDEL NNP cord-287815-alv30uk5 142 8 - - HYPH cord-287815-alv30uk5 142 9 tagged tag VBN cord-287815-alv30uk5 142 10 proteins protein NNS cord-287815-alv30uk5 142 11 to to IN cord-287815-alv30uk5 142 12 and and CC cord-287815-alv30uk5 142 13 from from IN cord-287815-alv30uk5 142 14 the the DT cord-287815-alv30uk5 142 15 Golgi Golgi NNP cord-287815-alv30uk5 142 16 and and CC cord-287815-alv30uk5 142 17 the the DT cord-287815-alv30uk5 142 18 limited limited JJ cord-287815-alv30uk5 142 19 post post JJ cord-287815-alv30uk5 142 20 - - JJ cord-287815-alv30uk5 142 21 ER er JJ cord-287815-alv30uk5 142 22 glycosylation glycosylation NN cord-287815-alv30uk5 142 23 events event NNS cord-287815-alv30uk5 142 24 to to TO cord-287815-alv30uk5 142 25 which which WDT cord-287815-alv30uk5 142 26 these these DT cord-287815-alv30uk5 142 27 proteins protein NNS cord-287815-alv30uk5 142 28 are be VBP cord-287815-alv30uk5 142 29 subjected subject VBN cord-287815-alv30uk5 142 30 , , , cord-287815-alv30uk5 142 31 the the DT cord-287815-alv30uk5 142 32 CGN CGN NNP cord-287815-alv30uk5 142 33 rnight rnight NN cord-287815-alv30uk5 142 34 also also RB cord-287815-alv30uk5 142 35 be be VB cord-287815-alv30uk5 142 36 predicted predict VBN cord-287815-alv30uk5 142 37 to to TO cord-287815-alv30uk5 142 38 include include VB cord-287815-alv30uk5 142 39 a a DT cord-287815-alv30uk5 142 40 variety variety NN cord-287815-alv30uk5 142 41 of of IN cord-287815-alv30uk5 142 42 other other JJ cord-287815-alv30uk5 142 43 activities activity NNS cord-287815-alv30uk5 142 44 that that WDT cord-287815-alv30uk5 142 45 have have VBP cord-287815-alv30uk5 142 46 been be VBN cord-287815-alv30uk5 142 47 relegated relegate VBN cord-287815-alv30uk5 142 48 to to IN cord-287815-alv30uk5 142 49 the the DT cord-287815-alv30uk5 142 50 purgatory purgatory NN cord-287815-alv30uk5 142 51 between between IN cord-287815-alv30uk5 142 52 the the DT cord-287815-alv30uk5 142 53 EIR EIR NNP cord-287815-alv30uk5 142 54 and and CC cord-287815-alv30uk5 142 55 the the DT cord-287815-alv30uk5 142 56 Golgi Golgi NNP cord-287815-alv30uk5 142 57 . . . cord-287815-alv30uk5 143 1 These these DT cord-287815-alv30uk5 143 2 would would MD cord-287815-alv30uk5 143 3 include include VB cord-287815-alv30uk5 143 4 the the DT cord-287815-alv30uk5 143 5 addition addition NN cord-287815-alv30uk5 143 6 of of IN cord-287815-alv30uk5 143 7 the the DT cord-287815-alv30uk5 143 8 first first JJ cord-287815-alv30uk5 143 9 N n CD cord-287815-alv30uk5 143 10 - - HYPH cord-287815-alv30uk5 143 11 acetylgalactosamine acetylgalactosamine JJ cord-287815-alv30uk5 143 12 residue residue NN cord-287815-alv30uk5 143 13 to to IN cord-287815-alv30uk5 143 14 O o NN cord-287815-alv30uk5 143 15 - - HYPH cord-287815-alv30uk5 143 16 linked link VBN cord-287815-alv30uk5 143 17 sugars sugar NNS cord-287815-alv30uk5 143 18 , , , cord-287815-alv30uk5 143 19 the the DT cord-287815-alv30uk5 143 20 assembly assembly NN cord-287815-alv30uk5 143 21 of of IN cord-287815-alv30uk5 143 22 coronavirus coronavirus NN cord-287815-alv30uk5 143 23 particles particle NNS cord-287815-alv30uk5 143 24 ( ( -LRB- cord-287815-alv30uk5 143 25 Tooze Tooze NNP cord-287815-alv30uk5 143 26 et et NNP cord-287815-alv30uk5 143 27 al al NNP cord-287815-alv30uk5 143 28 . . NNP cord-287815-alv30uk5 143 29 , , , cord-287815-alv30uk5 143 30 1988 1988 CD cord-287815-alv30uk5 143 31 ; ; : cord-287815-alv30uk5 143 32 Machamer Machamer NNP cord-287815-alv30uk5 143 33 et et NNP cord-287815-alv30uk5 143 34 al al NNP cord-287815-alv30uk5 143 35 . . NNP cord-287815-alv30uk5 143 36 , , , cord-287815-alv30uk5 143 37 1990 1990 CD cord-287815-alv30uk5 143 38 ) ) -RRB- cord-287815-alv30uk5 143 39 and and CC cord-287815-alv30uk5 143 40 fatty fatty JJ cord-287815-alv30uk5 143 41 acylation acylation NN cord-287815-alv30uk5 143 42 of of IN cord-287815-alv30uk5 143 43 membrane membrane NN cord-287815-alv30uk5 143 44 protein protein NN cord-287815-alv30uk5 143 45 cytoplasmic cytoplasmic JJ cord-287815-alv30uk5 143 46 domains domain NNS cord-287815-alv30uk5 143 47 ( ( -LRB- cord-287815-alv30uk5 143 48 Rizzolo Rizzolo NNP cord-287815-alv30uk5 143 49 and and CC cord-287815-alv30uk5 143 50 Kornfeld Kornfeld NNP cord-287815-alv30uk5 143 51 , , , cord-287815-alv30uk5 143 52 1988 1988 CD cord-287815-alv30uk5 143 53 ; ; : cord-287815-alv30uk5 144 1 E3onatti E3onatti NNP cord-287815-alv30uk5 144 2 et et FW cord-287815-alv30uk5 144 3 al al NNP cord-287815-alv30uk5 144 4 . . NNP cord-287815-alv30uk5 144 5 , , , cord-287815-alv30uk5 144 6 1989 1989 CD cord-287815-alv30uk5 144 7 ) ) -RRB- cord-287815-alv30uk5 144 8 . . . cord-287815-alv30uk5 145 1 Experiments experiment NNS cord-287815-alv30uk5 145 2 in in IN cord-287815-alv30uk5 145 3 yeast yeast NN cord-287815-alv30uk5 145 4 also also RB cord-287815-alv30uk5 145 5 give give VBP cord-287815-alv30uk5 145 6 at at IN cord-287815-alv30uk5 145 7 least least JJS cord-287815-alv30uk5 145 8 indirect indirect JJ cord-287815-alv30uk5 145 9 support support NN cord-287815-alv30uk5 145 10 to to IN cord-287815-alv30uk5 145 11 the the DT cord-287815-alv30uk5 145 12 existence existence NN cord-287815-alv30uk5 145 13 of of IN cord-287815-alv30uk5 145 14 lipid lipid NN cord-287815-alv30uk5 145 15 recycling recycling NN cord-287815-alv30uk5 145 16 to to IN cord-287815-alv30uk5 145 17 the the DT cord-287815-alv30uk5 145 18 ER ER NNP cord-287815-alv30uk5 145 19 from from IN cord-287815-alv30uk5 145 20 the the DT cord-287815-alv30uk5 145 21 CGN CGN NNP cord-287815-alv30uk5 145 22 as as RB cord-287815-alv30uk5 145 23 well well RB cord-287815-alv30uk5 145 24 ( ( -LRB- cord-287815-alv30uk5 145 25 Cleves Cleves NNP cord-287815-alv30uk5 145 26 et et NNP cord-287815-alv30uk5 145 27 al al NNP cord-287815-alv30uk5 145 28 . . NNP cord-287815-alv30uk5 145 29 , , , cord-287815-alv30uk5 145 30 1991 1991 CD cord-287815-alv30uk5 145 31 ) ) -RRB- cord-287815-alv30uk5 145 32 . . . cord-287815-alv30uk5 146 1 The the DT cord-287815-alv30uk5 146 2 medial medial JJ cord-287815-alv30uk5 146 3 Golgi Golgi NNP cord-287815-alv30uk5 146 4 would would MD cord-287815-alv30uk5 146 5 function function VB cord-287815-alv30uk5 146 6 primarily primarily RB cord-287815-alv30uk5 146 7 as as IN cord-287815-alv30uk5 146 8 a a DT cord-287815-alv30uk5 146 9 glycosylation glycosylation NN cord-287815-alv30uk5 146 10 device device NN cord-287815-alv30uk5 146 11 . . . cord-287815-alv30uk5 147 1 Structurally structurally RB cord-287815-alv30uk5 147 2 , , , cord-287815-alv30uk5 147 3 it -PRON- PRP cord-287815-alv30uk5 147 4 corresponds correspond VBZ cord-287815-alv30uk5 147 5 to to IN cord-287815-alv30uk5 147 6 the the DT cord-287815-alv30uk5 147 7 cisternae cisternae NN cord-287815-alv30uk5 147 8 and and CC cord-287815-alv30uk5 147 9 tubules tubule NNS cord-287815-alv30uk5 147 10 in in IN cord-287815-alv30uk5 147 11 the the DT cord-287815-alv30uk5 147 12 middle middle NN cord-287815-alv30uk5 147 13 of of IN cord-287815-alv30uk5 147 14 the the DT cord-287815-alv30uk5 147 15 Golgi Golgi NNP cord-287815-alv30uk5 147 16 stack stack NN cord-287815-alv30uk5 147 17 ( ( -LRB- cord-287815-alv30uk5 147 18 Figure figure NN cord-287815-alv30uk5 147 19 3 3 CD cord-287815-alv30uk5 147 20 ) ) -RRB- cord-287815-alv30uk5 147 21 whose whose WP$ cord-287815-alv30uk5 147 22 structures structure NNS cord-287815-alv30uk5 147 23 vary vary VBP cord-287815-alv30uk5 147 24 widely widely RB cord-287815-alv30uk5 147 25 in in IN cord-287815-alv30uk5 147 26 different different JJ cord-287815-alv30uk5 147 27 cells cell NNS cord-287815-alv30uk5 147 28 ( ( -LRB- cord-287815-alv30uk5 147 29 Rambourg Rambourg NNP cord-287815-alv30uk5 147 30 and and CC cord-287815-alv30uk5 147 31 Clermont Clermont NNP cord-287815-alv30uk5 147 32 , , , cord-287815-alv30uk5 147 33 1990 1990 CD cord-287815-alv30uk5 147 34 ) ) -RRB- cord-287815-alv30uk5 147 35 . . . cord-287815-alv30uk5 148 1 While while IN cord-287815-alv30uk5 148 2 distinct distinct JJ cord-287815-alv30uk5 148 3 from from IN cord-287815-alv30uk5 148 4 the the DT cord-287815-alv30uk5 148 5 CGN CGN NNP cord-287815-alv30uk5 148 6 or or CC cord-287815-alv30uk5 148 7 TGN TGN NNP cord-287815-alv30uk5 148 8 , , , cord-287815-alv30uk5 148 9 we -PRON- PRP cord-287815-alv30uk5 148 10 assume assume VBP cord-287815-alv30uk5 148 11 that that IN cord-287815-alv30uk5 148 12 the the DT cord-287815-alv30uk5 148 13 medial medial JJ cord-287815-alv30uk5 148 14 cisternae cisternae NNP cord-287815-alv30uk5 148 15 represent represent VBP cord-287815-alv30uk5 148 16 a a DT cord-287815-alv30uk5 148 17 single single JJ cord-287815-alv30uk5 148 18 functionally functionally RB cord-287815-alv30uk5 148 19 continuous continuous JJ cord-287815-alv30uk5 148 20 compartment compartment NN cord-287815-alv30uk5 148 21 , , , cord-287815-alv30uk5 148 22 irrespective irrespective RB cord-287815-alv30uk5 148 23 of of IN cord-287815-alv30uk5 148 24 the the DT cord-287815-alv30uk5 148 25 actual actual JJ cord-287815-alv30uk5 148 26 number number NN cord-287815-alv30uk5 148 27 of of IN cord-287815-alv30uk5 148 28 physically physically RB cord-287815-alv30uk5 148 29 separate separate JJ cord-287815-alv30uk5 148 30 cisternal cisternal JJ cord-287815-alv30uk5 148 31 elements element NNS cord-287815-alv30uk5 148 32 in in IN cord-287815-alv30uk5 148 33 any any DT cord-287815-alv30uk5 148 34 one one CD cord-287815-alv30uk5 148 35 Golgi Golgi NNP cord-287815-alv30uk5 148 36 complex complex NN cord-287815-alv30uk5 148 37 . . . cord-287815-alv30uk5 149 1 Nevertheless nevertheless RB cord-287815-alv30uk5 149 2 , , , cord-287815-alv30uk5 149 3 owing owe VBG cord-287815-alv30uk5 149 4 to to IN cord-287815-alv30uk5 149 5 the the DT cord-287815-alv30uk5 149 6 sidedness sidedness NN cord-287815-alv30uk5 149 7 of of IN cord-287815-alv30uk5 149 8 the the DT cord-287815-alv30uk5 149 9 Golgi Golgi NNP cord-287815-alv30uk5 149 10 , , , cord-287815-alv30uk5 149 11 the the DT cord-287815-alv30uk5 149 12 medial medial JJ cord-287815-alv30uk5 149 13 cisternae cisternae NNP cord-287815-alv30uk5 149 14 may may MD cord-287815-alv30uk5 149 15 appear appear VB cord-287815-alv30uk5 149 16 structurally structurally RB cord-287815-alv30uk5 149 17 distinct distinct JJ cord-287815-alv30uk5 149 18 . . . cord-287815-alv30uk5 150 1 For for IN cord-287815-alv30uk5 150 2 example example NN cord-287815-alv30uk5 150 3 , , , cord-287815-alv30uk5 150 4 since since IN cord-287815-alv30uk5 150 5 one one CD cord-287815-alv30uk5 150 6 face face NN cord-287815-alv30uk5 150 7 of of IN cord-287815-alv30uk5 150 8 a a DT cord-287815-alv30uk5 150 9 medial medial JJ cord-287815-alv30uk5 150 10 cisterna cisterna NN cord-287815-alv30uk5 150 11 is be VBZ cord-287815-alv30uk5 150 12 apposed appose VBN cord-287815-alv30uk5 150 13 to to IN cord-287815-alv30uk5 150 14 the the DT cord-287815-alv30uk5 150 15 CGN CGN NNP cord-287815-alv30uk5 150 16 while while IN cord-287815-alv30uk5 150 17 another another DT cord-287815-alv30uk5 150 18 face face NN cord-287815-alv30uk5 150 19 is be VBZ cord-287815-alv30uk5 150 20 apposed appose VBN cord-287815-alv30uk5 150 21 to to IN cord-287815-alv30uk5 150 22 the the DT cord-287815-alv30uk5 150 23 TGN TGN NNP cord-287815-alv30uk5 150 24 , , , cord-287815-alv30uk5 150 25 the the DT cord-287815-alv30uk5 150 26 two two CD cord-287815-alv30uk5 150 27 faces face NNS cord-287815-alv30uk5 150 28 may may MD cord-287815-alv30uk5 150 29 have have VB cord-287815-alv30uk5 150 30 different different JJ cord-287815-alv30uk5 150 31 compositions composition NNS cord-287815-alv30uk5 150 32 , , , cord-287815-alv30uk5 150 33 owing owe VBG cord-287815-alv30uk5 150 34 to to IN cord-287815-alv30uk5 150 35 their -PRON- PRP$ cord-287815-alv30uk5 150 36 interactions interaction NNS cord-287815-alv30uk5 150 37 with with IN cord-287815-alv30uk5 150 38 structurally structurally RB cord-287815-alv30uk5 150 39 distinct distinct JJ cord-287815-alv30uk5 150 40 compartments compartment NNS cord-287815-alv30uk5 150 41 . . . cord-287815-alv30uk5 151 1 Most Most JJS cord-287815-alv30uk5 151 2 of of IN cord-287815-alv30uk5 151 3 the the DT cord-287815-alv30uk5 151 4 glycosylation glycosylation NN cord-287815-alv30uk5 151 5 reactions reaction NNS cord-287815-alv30uk5 151 6 ( ( -LRB- cord-287815-alv30uk5 151 7 N n NN cord-287815-alv30uk5 151 8 - - HYPH cord-287815-alv30uk5 151 9 linked link VBN cord-287815-alv30uk5 151 10 , , , cord-287815-alv30uk5 151 11 O o NN cord-287815-alv30uk5 151 12 - - HYPH cord-287815-alv30uk5 151 13 linked link VBN cord-287815-alv30uk5 151 14 , , , cord-287815-alv30uk5 151 15 as as RB cord-287815-alv30uk5 151 16 well well RB cord-287815-alv30uk5 151 17 as as IN cord-287815-alv30uk5 151 18 glycolipid glycolipid NNP cord-287815-alv30uk5 151 19 synthesis synthesis NNP cord-287815-alv30uk5 151 20 ) ) -RRB- cord-287815-alv30uk5 151 21 , , , cord-287815-alv30uk5 151 22 aswell aswell RB cord-287815-alv30uk5 151 23 as as IN cord-287815-alv30uk5 151 24 polysaccharide polysaccharide NN cord-287815-alv30uk5 151 25 synthesis synthesis NN cord-287815-alv30uk5 151 26 normally normally RB cord-287815-alv30uk5 151 27 associated associate VBN cord-287815-alv30uk5 151 28 with with IN cord-287815-alv30uk5 151 29 the the DT cord-287815-alv30uk5 151 30 Golgi Golgi NNP cord-287815-alv30uk5 151 31 , , , cord-287815-alv30uk5 151 32 are be VBP cord-287815-alv30uk5 151 33 viewed view VBN cord-287815-alv30uk5 151 34 as as IN cord-287815-alv30uk5 151 35 occurring occur VBG cord-287815-alv30uk5 151 36 in in IN cord-287815-alv30uk5 151 37 the the DT cord-287815-alv30uk5 151 38 medial medial JJ cord-287815-alv30uk5 151 39 compartment compartment NN cord-287815-alv30uk5 151 40 . . . cord-287815-alv30uk5 152 1 This this DT cord-287815-alv30uk5 152 2 arrangement arrangement NN cord-287815-alv30uk5 152 3 would would MD cord-287815-alv30uk5 152 4 account account VB cord-287815-alv30uk5 152 5 for for IN cord-287815-alv30uk5 152 6 cell cell NN cord-287815-alv30uk5 152 7 type type NN cord-287815-alv30uk5 152 8 heterogeneity heterogeneity NN cord-287815-alv30uk5 152 9 in in IN cord-287815-alv30uk5 152 10 cisternal cisternal JJ cord-287815-alv30uk5 152 11 number number NN cord-287815-alv30uk5 152 12 and and CC cord-287815-alv30uk5 152 13 enzyme enzyme NN cord-287815-alv30uk5 152 14 distribution distribution NN cord-287815-alv30uk5 152 15 by by IN cord-287815-alv30uk5 152 16 placing place VBG cord-287815-alv30uk5 152 17 them -PRON- PRP cord-287815-alv30uk5 152 18 all all DT cord-287815-alv30uk5 152 19 in in IN cord-287815-alv30uk5 152 20 asingle asingle NNP cord-287815-alv30uk5 152 21 compartment compartment NNP cord-287815-alv30uk5 152 22 . . . cord-287815-alv30uk5 153 1 At at IN cord-287815-alv30uk5 153 2 present present JJ cord-287815-alv30uk5 153 3 , , , cord-287815-alv30uk5 153 4 there there EX cord-287815-alv30uk5 153 5 is be VBZ cord-287815-alv30uk5 153 6 insufficient insufficient JJ cord-287815-alv30uk5 153 7 data datum NNS cord-287815-alv30uk5 153 8 to to TO cord-287815-alv30uk5 153 9 know know VB cord-287815-alv30uk5 153 10 if if IN cord-287815-alv30uk5 153 11 this this DT cord-287815-alv30uk5 153 12 is be VBZ cord-287815-alv30uk5 153 13 really really RB cord-287815-alv30uk5 153 14 the the DT cord-287815-alv30uk5 153 15 case case NN cord-287815-alv30uk5 153 16 . . . cord-287815-alv30uk5 154 1 If if IN cord-287815-alv30uk5 154 2 the the DT cord-287815-alv30uk5 154 3 medial medial JJ cord-287815-alv30uk5 154 4 Golgi Golgi NNP cord-287815-alv30uk5 154 5 serves serve VBZ cord-287815-alv30uk5 154 6 only only RB cord-287815-alv30uk5 154 7 to to TO cord-287815-alv30uk5 154 8 mediate mediate VB cord-287815-alv30uk5 154 9 glycosylation glycosylation NN cord-287815-alv30uk5 154 10 reactions reaction NNS cord-287815-alv30uk5 154 11 , , , cord-287815-alv30uk5 154 12 why why WRB cord-287815-alv30uk5 154 13 the the DT cord-287815-alv30uk5 154 14 characteristic characteristic JJ cord-287815-alv30uk5 154 15 cisternal cisternal JJ cord-287815-alv30uk5 154 16 morphology morphology NN cord-287815-alv30uk5 154 17 ? ? . cord-287815-alv30uk5 155 1 One one CD cord-287815-alv30uk5 155 2 possibility possibility NN cord-287815-alv30uk5 155 3 might may MD cord-287815-alv30uk5 155 4 be be VB cord-287815-alv30uk5 155 5 simply simply RB cord-287815-alv30uk5 155 6 to to TO cord-287815-alv30uk5 155 7 enhance enhance VB cord-287815-alv30uk5 155 8 the the DT cord-287815-alv30uk5 155 9 efficiency efficiency NN cord-287815-alv30uk5 155 10 of of IN cord-287815-alv30uk5 155 11 glycosylation glycosylation NN cord-287815-alv30uk5 155 12 . . . cord-287815-alv30uk5 156 1 Although although IN cord-287815-alv30uk5 156 2 precise precise JJ cord-287815-alv30uk5 156 3 measurements measurement NNS cord-287815-alv30uk5 156 4 are be VBP cord-287815-alv30uk5 156 5 difficult difficult JJ cord-287815-alv30uk5 156 6 to to TO cord-287815-alv30uk5 156 7 make make VB cord-287815-alv30uk5 156 8 , , , cord-287815-alv30uk5 156 9 transport transport VB cord-287815-alv30uk5 156 10 systems system NNS cord-287815-alv30uk5 156 11 for for IN cord-287815-alv30uk5 156 12 sugar sugar NN cord-287815-alv30uk5 156 13 nucleotide nucleotide JJ cord-287815-alv30uk5 156 14 precursors precursor NNS cord-287815-alv30uk5 156 15 are be VBP cord-287815-alv30uk5 156 16 kinetically kinetically RB cord-287815-alv30uk5 156 17 inefficient inefficient JJ cord-287815-alv30uk5 157 1 ( ( -LRB- cord-287815-alv30uk5 157 2 Deutscher Deutscher NNP cord-287815-alv30uk5 157 3 et et NNP cord-287815-alv30uk5 157 4 al al NNP cord-287815-alv30uk5 157 5 . . NNP cord-287815-alv30uk5 157 6 , , , cord-287815-alv30uk5 157 7 1984 1984 CD cord-287815-alv30uk5 157 8 ) ) -RRB- cord-287815-alv30uk5 157 9 . . . cord-287815-alv30uk5 158 1 Moreover moreover RB cord-287815-alv30uk5 158 2 , , , cord-287815-alv30uk5 158 3 while while IN cord-287815-alv30uk5 158 4 the the DT cord-287815-alv30uk5 158 5 terminal terminal JJ cord-287815-alv30uk5 158 6 transferases transferase NNS cord-287815-alv30uk5 158 7 also also RB cord-287815-alv30uk5 158 8 have have VBP cord-287815-alv30uk5 158 9 relatively relatively RB cord-287815-alv30uk5 158 10 high high JJ cord-287815-alv30uk5 158 11 K K NNP cord-287815-alv30uk5 158 12 , , , cord-287815-alv30uk5 158 13 s s NNP cord-287815-alv30uk5 158 14 for for IN cord-287815-alv30uk5 158 15 substrate substrate NN cord-287815-alv30uk5 158 16 ( ( -LRB- cord-287815-alv30uk5 158 17 high high JJ cord-287815-alv30uk5 158 18 micromolar micromolar JJ cord-287815-alv30uk5 158 19 range range NN cord-287815-alv30uk5 158 20 ) ) -RRB- cord-287815-alv30uk5 158 21 , , , cord-287815-alv30uk5 158 22 they -PRON- PRP cord-287815-alv30uk5 158 23 may may MD cord-287815-alv30uk5 158 24 work work VB cord-287815-alv30uk5 158 25 at at IN cord-287815-alv30uk5 158 26 rates rate NNS cord-287815-alv30uk5 158 27 that that WDT cord-287815-alv30uk5 158 28 may may MD cord-287815-alv30uk5 158 29 exceed exceed VB cord-287815-alv30uk5 158 30 the the DT cord-287815-alv30uk5 158 31 rate rate NN cord-287815-alv30uk5 158 32 of of IN cord-287815-alv30uk5 158 33 sugar sugar NN cord-287815-alv30uk5 158 34 nucleotide nucleotide JJ cord-287815-alv30uk5 158 35 transport transport NN cord-287815-alv30uk5 158 36 ( ( -LRB- cord-287815-alv30uk5 158 37 Weinstein Weinstein NNP cord-287815-alv30uk5 158 38 et et NNP cord-287815-alv30uk5 158 39 al al NNP cord-287815-alv30uk5 158 40 . . NNP cord-287815-alv30uk5 158 41 , , , cord-287815-alv30uk5 158 42 1982 1982 CD cord-287815-alv30uk5 158 43 ; ; : cord-287815-alv30uk5 158 44 C. C. NNP cord-287815-alv30uk5 158 45 Hirschberg Hirschberg NNP cord-287815-alv30uk5 158 46 , , , cord-287815-alv30uk5 158 47 personal personal JJ cord-287815-alv30uk5 158 48 communication communication NN cord-287815-alv30uk5 158 49 ) ) -RRB- cord-287815-alv30uk5 158 50 . . . cord-287815-alv30uk5 159 1 Thus thus RB cord-287815-alv30uk5 159 2 , , , cord-287815-alv30uk5 159 3 the the DT cord-287815-alv30uk5 159 4 cisternal cisternal JJ cord-287815-alv30uk5 159 5 stack stack NN cord-287815-alv30uk5 159 6 by by IN cord-287815-alv30uk5 159 7 its -PRON- PRP$ cord-287815-alv30uk5 159 8 flattened flattened JJ cord-287815-alv30uk5 159 9 structure structure NN cord-287815-alv30uk5 159 10 may may MD cord-287815-alv30uk5 159 11 serve serve VB cord-287815-alv30uk5 159 12 to to TO cord-287815-alv30uk5 159 13 enhance enhance VB cord-287815-alv30uk5 159 14 the the DT cord-287815-alv30uk5 159 15 efficiency efficiency NN cord-287815-alv30uk5 159 16 of of IN cord-287815-alv30uk5 159 17 glycosylation glycosylation NN cord-287815-alv30uk5 159 18 by by IN cord-287815-alv30uk5 159 19 minimizing minimize VBG cord-287815-alv30uk5 159 20 lumenal lumenal JJ cord-287815-alv30uk5 159 21 volume volume NN cord-287815-alv30uk5 159 22 and and CC cord-287815-alv30uk5 159 23 increasing increase VBG cord-287815-alv30uk5 159 24 membrane membrane NN cord-287815-alv30uk5 159 25 surface surface NN cord-287815-alv30uk5 159 26 area area NN cord-287815-alv30uk5 159 27 . . . cord-287815-alv30uk5 160 1 The the DT cord-287815-alv30uk5 160 2 TGN TGN NNP cord-287815-alv30uk5 160 3 is be VBZ cord-287815-alv30uk5 160 4 viewed view VBN cord-287815-alv30uk5 160 5 as as IN cord-287815-alv30uk5 160 6 the the DT cord-287815-alv30uk5 160 7 compartment compartment NN cord-287815-alv30uk5 160 8 that that WDT cord-287815-alv30uk5 160 9 mediates mediate VBZ cord-287815-alv30uk5 160 10 the the DT cord-287815-alv30uk5 160 11 sorting sorting NN cord-287815-alv30uk5 160 12 and and CC cord-287815-alv30uk5 160 13 final final JJ cord-287815-alv30uk5 160 14 exit exit NN cord-287815-alv30uk5 160 15 of of IN cord-287815-alv30uk5 160 16 material material NN cord-287815-alv30uk5 160 17 from from IN cord-287815-alv30uk5 160 18 the the DT cord-287815-alv30uk5 160 19 Golgi Golgi NNP cord-287815-alv30uk5 160 20 . . . cord-287815-alv30uk5 161 1 Structurally structurally RB cord-287815-alv30uk5 161 2 , , , cord-287815-alv30uk5 161 3 it -PRON- PRP cord-287815-alv30uk5 161 4 is be VBZ cord-287815-alv30uk5 161 5 likely likely JJ cord-287815-alv30uk5 161 6 to to TO cord-287815-alv30uk5 161 7 be be VB cord-287815-alv30uk5 161 8 defined define VBN cord-287815-alv30uk5 161 9 by by IN cord-287815-alv30uk5 161 10 the the DT cord-287815-alv30uk5 161 11 sacculotubular sacculotubular NNP cord-287815-alv30uk5 161 12 network network NN cord-287815-alv30uk5 161 13 located locate VBN cord-287815-alv30uk5 161 14 on on IN cord-287815-alv30uk5 161 15 the the DT cord-287815-alv30uk5 161 16 trans trans JJ cord-287815-alv30uk5 161 17 side side NN cord-287815-alv30uk5 161 18 of of IN cord-287815-alv30uk5 161 19 the the DT cord-287815-alv30uk5 161 20 Golgi Golgi NNP cord-287815-alv30uk5 161 21 that that WDT cord-287815-alv30uk5 161 22 varies vary VBZ cord-287815-alv30uk5 161 23 in in IN cord-287815-alv30uk5 161 24 structure structure NN cord-287815-alv30uk5 161 25 in in IN cord-287815-alv30uk5 161 26 different different JJ cord-287815-alv30uk5 161 27 cell cell NN cord-287815-alv30uk5 161 28 types type NNS cord-287815-alv30uk5 161 29 ( ( -LRB- cord-287815-alv30uk5 161 30 Rambourg Rambourg NNP cord-287815-alv30uk5 161 31 and and CC cord-287815-alv30uk5 161 32 Clermont Clermont NNP cord-287815-alv30uk5 161 33 , , , cord-287815-alv30uk5 161 34 1990 1990 CD cord-287815-alv30uk5 161 35 ) ) -RRB- cord-287815-alv30uk5 162 1 ( ( -LRB- cord-287815-alv30uk5 162 2 Figures figure NNS cord-287815-alv30uk5 162 3 2 2 CD cord-287815-alv30uk5 162 4 and and CC cord-287815-alv30uk5 162 5 3 3 CD cord-287815-alv30uk5 162 6 ) ) -RRB- cord-287815-alv30uk5 162 7 . . . cord-287815-alv30uk5 163 1 The the DT cord-287815-alv30uk5 163 2 TGN TGN NNP cord-287815-alv30uk5 163 3 can can MD cord-287815-alv30uk5 163 4 be be VB cord-287815-alv30uk5 163 5 visualized visualize VBN cord-287815-alv30uk5 163 6 in in IN cord-287815-alv30uk5 163 7 the the DT cord-287815-alv30uk5 163 8 electron electron NN cord-287815-alv30uk5 163 9 microscope microscope NN cord-287815-alv30uk5 163 10 after after IN cord-287815-alv30uk5 163 11 labeling label VBG cord-287815-alv30uk5 163 12 cells cell NNS cord-287815-alv30uk5 163 13 with with IN cord-287815-alv30uk5 163 14 Cs Cs NNP cord-287815-alv30uk5 163 15 - - HYPH cord-287815-alv30uk5 163 16 NBD NBD NNP cord-287815-alv30uk5 163 17 - - HYPH cord-287815-alv30uk5 163 18 ceramide ceramide NN cord-287815-alv30uk5 163 19 ( ( -LRB- cord-287815-alv30uk5 163 20 Pagan0 Pagan0 NNP cord-287815-alv30uk5 163 21 et et FW cord-287815-alv30uk5 163 22 al al NNP cord-287815-alv30uk5 163 23 . . NNP cord-287815-alv30uk5 163 24 , , , cord-287815-alv30uk5 163 25 1989 1989 CD cord-287815-alv30uk5 163 26 ) ) -RRB- cord-287815-alv30uk5 163 27 with with IN cord-287815-alv30uk5 163 28 Cs Cs NNP cord-287815-alv30uk5 163 29 - - HYPH cord-287815-alv30uk5 163 30 DMB DMB NNP cord-287815-alv30uk5 163 31 - - HYPH cord-287815-alv30uk5 163 32 ceramide ceramide NN cord-287815-alv30uk5 163 33 ( ( -LRB- cord-287815-alv30uk5 163 34 Pagan0 Pagan0 NNP cord-287815-alv30uk5 163 35 et et FW cord-287815-alv30uk5 163 36 al al NNP cord-287815-alv30uk5 163 37 . . NNP cord-287815-alv30uk5 163 38 , , , cord-287815-alv30uk5 163 39 1991 1991 CD cord-287815-alv30uk5 163 40 ) ) -RRB- cord-287815-alv30uk5 163 41 or or CC cord-287815-alv30uk5 163 42 after after IN cord-287815-alv30uk5 163 43 accumulating accumulate VBG cord-287815-alv30uk5 163 44 vesicular vesicular JJ cord-287815-alv30uk5 163 45 stomatitis stomatitis NN cord-287815-alv30uk5 163 46 virus virus NN cord-287815-alv30uk5 163 47 ( ( -LRB- cord-287815-alv30uk5 163 48 VSV VSV NNP cord-287815-alv30uk5 163 49 ) ) -RRB- cord-287815-alv30uk5 163 50 G g NN cord-287815-alv30uk5 163 51 protein protein NN cord-287815-alv30uk5 163 52 at at IN cord-287815-alv30uk5 163 53 20 20 CD cord-287815-alv30uk5 163 54 % % NN cord-287815-alv30uk5 163 55 ( ( -LRB- cord-287815-alv30uk5 163 56 Griffiths Griffiths NNP cord-287815-alv30uk5 163 57 et et NNP cord-287815-alv30uk5 163 58 al al NNP cord-287815-alv30uk5 163 59 . . NNP cord-287815-alv30uk5 163 60 , , , cord-287815-alv30uk5 163 61 1985 1985 CD cord-287815-alv30uk5 163 62 ) ) -RRB- cord-287815-alv30uk5 163 63 . . . cord-287815-alv30uk5 164 1 The the DT cord-287815-alv30uk5 164 2 TGN TGN NNP cord-287815-alv30uk5 164 3 may may MD cord-287815-alv30uk5 164 4 also also RB cord-287815-alv30uk5 164 5 have have VB cord-287815-alv30uk5 164 6 a a DT cord-287815-alv30uk5 164 7 lower low JJR cord-287815-alv30uk5 164 8 pH ph NN cord-287815-alv30uk5 164 9 than than IN cord-287815-alv30uk5 164 10 preceding precede VBG cord-287815-alv30uk5 164 11 compartments compartment NNS cord-287815-alv30uk5 164 12 in in IN cord-287815-alv30uk5 164 13 the the DT cord-287815-alv30uk5 164 14 pathway pathway NN cord-287815-alv30uk5 164 15 ( ( -LRB- cord-287815-alv30uk5 164 16 Anderson Anderson NNP cord-287815-alv30uk5 164 17 and and CC cord-287815-alv30uk5 164 18 Pathak Pathak NNP cord-287815-alv30uk5 164 19 , , , cord-287815-alv30uk5 164 20 1985 1985 CD cord-287815-alv30uk5 164 21 ) ) -RRB- cord-287815-alv30uk5 164 22 . . . cord-287815-alv30uk5 165 1 The the DT cord-287815-alv30uk5 165 2 TGN TGN NNP cord-287815-alv30uk5 165 3 is be VBZ cord-287815-alv30uk5 165 4 known know VBN cord-287815-alv30uk5 165 5 to to TO cord-287815-alv30uk5 165 6 undergo undergo VB cord-287815-alv30uk5 165 7 dynamic dynamic JJ cord-287815-alv30uk5 165 8 changes change NNS cord-287815-alv30uk5 165 9 in in IN cord-287815-alv30uk5 165 10 size size NN cord-287815-alv30uk5 165 11 , , , cord-287815-alv30uk5 165 12 depending depend VBG cord-287815-alv30uk5 165 13 on on IN cord-287815-alv30uk5 165 14 the the DT cord-287815-alv30uk5 165 15 amount amount NN cord-287815-alv30uk5 165 16 of of IN cord-287815-alv30uk5 165 17 protein protein NN cord-287815-alv30uk5 165 18 traffic traffic NN cord-287815-alv30uk5 165 19 through through IN cord-287815-alv30uk5 165 20 the the DT cord-287815-alv30uk5 165 21 compartment compartment NN cord-287815-alv30uk5 165 22 ( ( -LRB- cord-287815-alv30uk5 165 23 Griffiths Griffiths NNP cord-287815-alv30uk5 165 24 et et NNP cord-287815-alv30uk5 165 25 al al NNP cord-287815-alv30uk5 165 26 . . NNP cord-287815-alv30uk5 165 27 , , , cord-287815-alv30uk5 165 28 1989 1989 CD cord-287815-alv30uk5 165 29 ) ) -RRB- cord-287815-alv30uk5 165 30 . . . cord-287815-alv30uk5 166 1 In in IN cord-287815-alv30uk5 166 2 glandular glandular JJ cord-287815-alv30uk5 166 3 cells cell NNS cord-287815-alv30uk5 166 4 producing produce VBG cord-287815-alv30uk5 166 5 secretion secretion NN cord-287815-alv30uk5 166 6 granules granule NNS cord-287815-alv30uk5 166 7 , , , cord-287815-alv30uk5 166 8 several several JJ cord-287815-alv30uk5 166 9 cisternae cisternae NN cord-287815-alv30uk5 166 10 on on IN cord-287815-alv30uk5 166 11 the the DT cord-287815-alv30uk5 166 12 trans trans NNP cord-287815-alv30uk5 166 13 side side NN cord-287815-alv30uk5 166 14 form form NN cord-287815-alv30uk5 166 15 condensing condense VBG cord-287815-alv30uk5 166 16 vacuoles vacuole NNS cord-287815-alv30uk5 166 17 , , , cord-287815-alv30uk5 166 18 presuming presume VBG cord-287815-alv30uk5 166 19 that that IN cord-287815-alv30uk5 166 20 all all PDT cord-287815-alv30uk5 166 21 these these DT cord-287815-alv30uk5 166 22 cisternae cisternae NNP cord-287815-alv30uk5 166 23 are be VBP cord-287815-alv30uk5 166 24 part part NN cord-287815-alv30uk5 166 25 of of IN cord-287815-alv30uk5 166 26 the the DT cord-287815-alv30uk5 166 27 TGN TGN NNP cord-287815-alv30uk5 166 28 ( ( -LRB- cord-287815-alv30uk5 166 29 Rambourg Rambourg NNP cord-287815-alv30uk5 166 30 and and CC cord-287815-alv30uk5 166 31 Clermont Clermont NNP cord-287815-alv30uk5 166 32 , , , cord-287815-alv30uk5 166 33 1990 1990 CD cord-287815-alv30uk5 166 34 ) ) -RRB- cord-287815-alv30uk5 166 35 . . . cord-287815-alv30uk5 167 1 The the DT cord-287815-alv30uk5 167 2 extreme extreme JJ cord-287815-alv30uk5 167 3 case case NN cord-287815-alv30uk5 167 4 is be VBZ cord-287815-alv30uk5 167 5 represented represent VBN cord-287815-alv30uk5 167 6 by by IN cord-287815-alv30uk5 167 7 the the DT cord-287815-alv30uk5 167 8 Golgi Golgi NNP cord-287815-alv30uk5 167 9 complex complex NN cord-287815-alv30uk5 167 10 of of IN cord-287815-alv30uk5 167 11 algae algae NN cord-287815-alv30uk5 167 12 where where WRB cord-287815-alv30uk5 167 13 flakes flake NNS cord-287815-alv30uk5 167 14 are be VBP cord-287815-alv30uk5 167 15 assembled assemble VBN cord-287815-alv30uk5 167 16 in in IN cord-287815-alv30uk5 167 17 the the DT cord-287815-alv30uk5 167 18 lumen lumen NN cord-287815-alv30uk5 167 19 of of IN cord-287815-alv30uk5 167 20 the the DT cord-287815-alv30uk5 167 21 Golgi Golgi NNP cord-287815-alv30uk5 167 22 cisternae cisternae NNP cord-287815-alv30uk5 168 1 ( ( -LRB- cord-287815-alv30uk5 168 2 Melkonian Melkonian NNP cord-287815-alv30uk5 168 3 et et FW cord-287815-alv30uk5 168 4 al al NNP cord-287815-alv30uk5 168 5 . . NNP cord-287815-alv30uk5 168 6 , , , cord-287815-alv30uk5 168 7 1991 1991 CD cord-287815-alv30uk5 168 8 ) ) -RRB- cord-287815-alv30uk5 168 9 . . . cord-287815-alv30uk5 169 1 Since since IN cord-287815-alv30uk5 169 2 these these DT cord-287815-alv30uk5 169 3 large large JJ cord-287815-alv30uk5 169 4 flakes flake NNS cord-287815-alv30uk5 169 5 are be VBP cord-287815-alv30uk5 169 6 first first RB cord-287815-alv30uk5 169 7 observed observe VBN cord-287815-alv30uk5 169 8 several several JJ cord-287815-alv30uk5 169 9 cisternae cisternae NN cord-287815-alv30uk5 169 10 away away RB cord-287815-alv30uk5 169 11 from from IN cord-287815-alv30uk5 169 12 the the DT cord-287815-alv30uk5 169 13 cis cis NNP cord-287815-alv30uk5 169 14 side side NN cord-287815-alv30uk5 169 15 , , , cord-287815-alv30uk5 169 16 it -PRON- PRP cord-287815-alv30uk5 169 17 seems seem VBZ cord-287815-alv30uk5 169 18 reasonable reasonable JJ cord-287815-alv30uk5 169 19 to to TO cord-287815-alv30uk5 169 20 assume assume VB cord-287815-alv30uk5 169 21 that that IN cord-287815-alv30uk5 169 22 the the DT cord-287815-alv30uk5 169 23 flakes flake NNS cord-287815-alv30uk5 169 24 assemble assemble VBP cord-287815-alv30uk5 169 25 in in IN cord-287815-alv30uk5 169 26 saccular saccular JJ cord-287815-alv30uk5 169 27 portions portion NNS cord-287815-alv30uk5 169 28 of of IN cord-287815-alv30uk5 169 29 the the DT cord-287815-alv30uk5 169 30 TGN TGN NNP cord-287815-alv30uk5 169 31 and and CC cord-287815-alv30uk5 169 32 that that IN cord-287815-alv30uk5 169 33 entire entire JJ cord-287815-alv30uk5 169 34 TGN TGN NNP cord-287815-alv30uk5 169 35 cisternae cisternae NNP cord-287815-alv30uk5 169 36 peel peel VB cord-287815-alv30uk5 169 37 off off RP cord-287815-alv30uk5 169 38 and and CC cord-287815-alv30uk5 169 39 are be VBP cord-287815-alv30uk5 169 40 transported transport VBN cord-287815-alv30uk5 169 41 to to IN cord-287815-alv30uk5 169 42 the the DT cord-287815-alv30uk5 169 43 cell cell NN cord-287815-alv30uk5 169 44 surface surface NN cord-287815-alv30uk5 169 45 . . . cord-287815-alv30uk5 170 1 The the DT cord-287815-alv30uk5 170 2 main main JJ cord-287815-alv30uk5 170 3 function function NN cord-287815-alv30uk5 170 4 of of IN cord-287815-alv30uk5 170 5 the the DT cord-287815-alv30uk5 170 6 TGN TGN NNP cord-287815-alv30uk5 170 7 is be VBZ cord-287815-alv30uk5 170 8 to to TO cord-287815-alv30uk5 170 9 sort sort VB cord-287815-alv30uk5 170 10 proteins protein NNS cord-287815-alv30uk5 170 11 and and CC cord-287815-alv30uk5 170 12 lipids lipid NNS cord-287815-alv30uk5 170 13 leaving leave VBG cord-287815-alv30uk5 170 14 for for IN cord-287815-alv30uk5 170 15 different different JJ cord-287815-alv30uk5 170 16 post post JJ cord-287815-alv30uk5 170 17 - - JJ cord-287815-alv30uk5 170 18 Golgi golgi JJ cord-287815-alv30uk5 170 19 destinations destination NNS cord-287815-alv30uk5 170 20 ( ( -LRB- cord-287815-alv30uk5 170 21 Griffiths Griffiths NNP cord-287815-alv30uk5 170 22 and and CC cord-287815-alv30uk5 170 23 Simons Simons NNP cord-287815-alv30uk5 170 24 , , , cord-287815-alv30uk5 170 25 1986 1986 CD cord-287815-alv30uk5 170 26 ; ; : cord-287815-alv30uk5 170 27 Simons Simons NNP cord-287815-alv30uk5 170 28 and and CC cord-287815-alv30uk5 170 29 van van NNP cord-287815-alv30uk5 170 30 Meer Meer NNP cord-287815-alv30uk5 170 31 , , , cord-287815-alv30uk5 170 32 1988 1988 CD cord-287815-alv30uk5 170 33 ) ) -RRB- cord-287815-alv30uk5 170 34 . . . cord-287815-alv30uk5 171 1 The the DT cord-287815-alv30uk5 171 2 TGN TGN NNP cord-287815-alv30uk5 171 3 also also RB cord-287815-alv30uk5 171 4 receives receive VBZ cord-287815-alv30uk5 171 5 membrane membrane NN cord-287815-alv30uk5 171 6 traffic traffic NN cord-287815-alv30uk5 171 7 from from IN cord-287815-alv30uk5 171 8 the the DT cord-287815-alv30uk5 171 9 endocytic endocytic JJ cord-287815-alv30uk5 171 10 pathway pathway NN cord-287815-alv30uk5 171 11 ( ( -LRB- cord-287815-alv30uk5 171 12 Farquhar Farquhar NNP cord-287815-alv30uk5 171 13 and and CC cord-287815-alv30uk5 171 14 Palade Palade NNP cord-287815-alv30uk5 171 15 , , , cord-287815-alv30uk5 171 16 1981 1981 CD cord-287815-alv30uk5 171 17 ; ; : cord-287815-alv30uk5 171 18 Kornfeld Kornfeld NNP cord-287815-alv30uk5 171 19 and and CC cord-287815-alv30uk5 171 20 Mellman Mellman NNP cord-287815-alv30uk5 171 21 , , , cord-287815-alv30uk5 171 22 1989 1989 CD cord-287815-alv30uk5 171 23 ) ) -RRB- cord-287815-alv30uk5 171 24 and and CC cord-287815-alv30uk5 171 25 , , , cord-287815-alv30uk5 171 26 unlike unlike IN cord-287815-alv30uk5 171 27 all all DT cord-287815-alv30uk5 171 28 other other JJ cord-287815-alv30uk5 171 29 Golgi Golgi NNP cord-287815-alv30uk5 171 30 subcompartments subcompartment NNS cord-287815-alv30uk5 171 31 , , , cord-287815-alv30uk5 171 32 its -PRON- PRP$ cord-287815-alv30uk5 171 33 degree degree NN cord-287815-alv30uk5 171 34 of of IN cord-287815-alv30uk5 171 35 continuity continuity NN cord-287815-alv30uk5 171 36 with with IN cord-287815-alv30uk5 171 37 the the DT cord-287815-alv30uk5 171 38 plasma plasma NN cord-287815-alv30uk5 171 39 membrane membrane NN cord-287815-alv30uk5 171 40 is be VBZ cord-287815-alv30uk5 171 41 increased increase VBN cord-287815-alv30uk5 171 42 following follow VBG cord-287815-alv30uk5 171 43 treatment treatment NN cord-287815-alv30uk5 171 44 with with IN cord-287815-alv30uk5 171 45 brefeldin brefeldin NNP cord-287815-alv30uk5 171 46 A A NNP cord-287815-alv30uk5 171 47 ( ( -LRB- cord-287815-alv30uk5 171 48 BFA BFA NNP cord-287815-alv30uk5 171 49 ) ) -RRB- cord-287815-alv30uk5 171 50 ( ( -LRB- cord-287815-alv30uk5 171 51 Lippincott- Lippincott- NNP cord-287815-alv30uk5 171 52 . . . cord-287815-alv30uk5 172 1 The the DT cord-287815-alv30uk5 172 2 TGN TGN NNP cord-287815-alv30uk5 172 3 is be VBZ cord-287815-alv30uk5 172 4 also also RB cord-287815-alv30uk5 172 5 the the DT cord-287815-alv30uk5 172 6 only only JJ cord-287815-alv30uk5 172 7 Golgi Golgi NNP cord-287815-alv30uk5 172 8 compartment compartment NN cord-287815-alv30uk5 172 9 that that WDT cord-287815-alv30uk5 172 10 fails fail VBZ cord-287815-alv30uk5 172 11 to to TO cord-287815-alv30uk5 172 12 enter enter VB cord-287815-alv30uk5 172 13 the the DT cord-287815-alv30uk5 172 14 ER ER NNP cord-287815-alv30uk5 172 15 following follow VBG cord-287815-alv30uk5 172 16 BFA BFA NNP cord-287815-alv30uk5 172 17 ( ( -LRB- cord-287815-alv30uk5 172 18 Chege Chege NNP cord-287815-alv30uk5 172 19 and and CC cord-287815-alv30uk5 172 20 Pfeffer Pfeffer NNP cord-287815-alv30uk5 172 21 , , , cord-287815-alv30uk5 172 22 1990 1990 CD cord-287815-alv30uk5 172 23 ; ; : cord-287815-alv30uk5 172 24 Ulmer Ulmer NNP cord-287815-alv30uk5 172 25 and and CC cord-287815-alv30uk5 172 26 Palade Palade NNP cord-287815-alv30uk5 172 27 , , , cord-287815-alv30uk5 172 28 1991 1991 CD cord-287815-alv30uk5 172 29 ; ; : cord-287815-alv30uk5 172 30 Reaves Reaves NNP cord-287815-alv30uk5 172 31 and and CC cord-287815-alv30uk5 172 32 Banting Banting NNP cord-287815-alv30uk5 172 33 , , , cord-287815-alv30uk5 172 34 1992 1992 CD cord-287815-alv30uk5 172 35 ) ) -RRB- cord-287815-alv30uk5 172 36 . . . cord-287815-alv30uk5 173 1 Certain certain JJ cord-287815-alv30uk5 173 2 " " `` cord-287815-alv30uk5 173 3 late late JJ cord-287815-alv30uk5 173 4 " " '' cord-287815-alv30uk5 173 5 protein protein NN cord-287815-alv30uk5 173 6 modification modification NN cord-287815-alv30uk5 173 7 events event NNS cord-287815-alv30uk5 173 8 also also RB cord-287815-alv30uk5 173 9 occur occur VBP cord-287815-alv30uk5 173 10 in in IN cord-287815-alv30uk5 173 11 the the DT cord-287815-alv30uk5 173 12 TGN TGN NNP cord-287815-alv30uk5 173 13 , , , cord-287815-alv30uk5 173 14 such such JJ cord-287815-alv30uk5 173 15 as as IN cord-287815-alv30uk5 173 16 galactose galactose NN cord-287815-alv30uk5 173 17 a2,6 a2,6 NN cord-287815-alv30uk5 173 18 sialylation sialylation NN cord-287815-alv30uk5 173 19 ( ( -LRB- cord-287815-alv30uk5 173 20 Duncan Duncan NNP cord-287815-alv30uk5 173 21 and and CC cord-287815-alv30uk5 173 22 Kornfeld Kornfeld NNP cord-287815-alv30uk5 173 23 , , , cord-287815-alv30uk5 173 24 1988 1988 CD cord-287815-alv30uk5 173 25 ) ) -RRB- cord-287815-alv30uk5 173 26 tyrosine tyrosine NN cord-287815-alv30uk5 173 27 sulfation sulfation NN cord-287815-alv30uk5 173 28 ( ( -LRB- cord-287815-alv30uk5 173 29 Huttner Huttner NNP cord-287815-alv30uk5 173 30 and and CC cord-287815-alv30uk5 173 31 Baeuerle Baeuerle NNP cord-287815-alv30uk5 173 32 , , , cord-287815-alv30uk5 173 33 1988 1988 CD cord-287815-alv30uk5 173 34 ) ) -RRB- cord-287815-alv30uk5 173 35 and and CC cord-287815-alv30uk5 173 36 proteolytic proteolytic JJ cord-287815-alv30uk5 173 37 cleavage cleavage NN cord-287815-alv30uk5 173 38 at at IN cord-287815-alv30uk5 173 39 dibasic dibasic NN cord-287815-alv30uk5 173 40 residues residue NNS cord-287815-alv30uk5 173 41 on on IN cord-287815-alv30uk5 173 42 viral viral JJ cord-287815-alv30uk5 173 43 glycoproteins glycoprotein NNS cord-287815-alv30uk5 173 44 and and CC cord-287815-alv30uk5 173 45 cellular cellular JJ cord-287815-alv30uk5 173 46 precursor precursor NN cord-287815-alv30uk5 173 47 proteins protein NNS cord-287815-alv30uk5 173 48 ( ( -LRB- cord-287815-alv30uk5 173 49 Sossin Sossin NNP cord-287815-alv30uk5 173 50 et et NNP cord-287815-alv30uk5 173 51 al al NNP cord-287815-alv30uk5 173 52 . . NNP cord-287815-alv30uk5 173 53 , , , cord-287815-alv30uk5 173 54 1990 1990 CD cord-287815-alv30uk5 173 55 ) ) -RRB- cord-287815-alv30uk5 173 56 . . . cord-287815-alv30uk5 174 1 We -PRON- PRP cord-287815-alv30uk5 174 2 propose propose VBP cord-287815-alv30uk5 174 3 that that IN cord-287815-alv30uk5 174 4 the the DT cord-287815-alv30uk5 174 5 TGN TGN NNP cord-287815-alv30uk5 174 6 also also RB cord-287815-alv30uk5 174 7 operates operate VBZ cord-287815-alv30uk5 174 8 as as IN cord-287815-alv30uk5 174 9 a a DT cord-287815-alv30uk5 174 10 directional directional JJ cord-287815-alv30uk5 174 11 valve valve NN cord-287815-alv30uk5 174 12 to to TO cord-287815-alv30uk5 174 13 control control VB cord-287815-alv30uk5 174 14 the the DT cord-287815-alv30uk5 174 15 flow flow NN cord-287815-alv30uk5 174 16 of of IN cord-287815-alv30uk5 174 17 membrane membrane NN cord-287815-alv30uk5 174 18 proteins protein NNS cord-287815-alv30uk5 174 19 and and CC cord-287815-alv30uk5 174 20 lipids lipid NNS cord-287815-alv30uk5 174 21 in in IN cord-287815-alv30uk5 174 22 biosynthetic biosynthetic JJ cord-287815-alv30uk5 174 23 transport transport NN cord-287815-alv30uk5 174 24 ( ( -LRB- cord-287815-alv30uk5 174 25 Figure figure NN cord-287815-alv30uk5 174 26 3 3 CD cord-287815-alv30uk5 174 27 ) ) -RRB- cord-287815-alv30uk5 174 28 . . . cord-287815-alv30uk5 175 1 Such such JJ cord-287815-alv30uk5 175 2 a a DT cord-287815-alv30uk5 175 3 function function NN cord-287815-alv30uk5 175 4 would would MD cord-287815-alv30uk5 175 5 contribute contribute VB cord-287815-alv30uk5 175 6 to to IN cord-287815-alv30uk5 175 7 the the DT cord-287815-alv30uk5 175 8 efficiency efficiency NN cord-287815-alv30uk5 175 9 of of IN cord-287815-alv30uk5 175 10 forward forward JJ cord-287815-alv30uk5 175 11 transport transport NN cord-287815-alv30uk5 175 12 by by IN cord-287815-alv30uk5 175 13 preventing prevent VBG cord-287815-alv30uk5 175 14 passenger passenger NN cord-287815-alv30uk5 175 15 proteins protein NNS cord-287815-alv30uk5 175 16 and and CC cord-287815-alv30uk5 175 17 lipids lipid NNS cord-287815-alv30uk5 175 18 from from IN cord-287815-alv30uk5 175 19 returning return VBG cord-287815-alv30uk5 175 20 to to IN cord-287815-alv30uk5 175 21 the the DT cord-287815-alv30uk5 175 22 medial medial JJ cord-287815-alv30uk5 175 23 Golgi Golgi NNP cord-287815-alv30uk5 175 24 after after IN cord-287815-alv30uk5 175 25 reaching reach VBG cord-287815-alv30uk5 175 26 the the DT cord-287815-alv30uk5 175 27 TGN TGN NNP cord-287815-alv30uk5 175 28 . . . cord-287815-alv30uk5 176 1 In in IN cord-287815-alv30uk5 176 2 practice practice NN cord-287815-alv30uk5 176 3 , , , cord-287815-alv30uk5 176 4 this this DT cord-287815-alv30uk5 176 5 would would MD cord-287815-alv30uk5 176 6 predict predict VB cord-287815-alv30uk5 176 7 that that IN cord-287815-alv30uk5 176 8 there there EX cord-287815-alv30uk5 176 9 is be VBZ cord-287815-alv30uk5 176 10 no no DT cord-287815-alv30uk5 176 11 recycling recycling NN cord-287815-alv30uk5 176 12 from from IN cord-287815-alv30uk5 176 13 the the DT cord-287815-alv30uk5 176 14 TGN TGN NNP cord-287815-alv30uk5 176 15 to to IN cord-287815-alv30uk5 176 16 the the DT cord-287815-alv30uk5 176 17 medial medial JJ cord-287815-alv30uk5 176 18 Golgi Golgi NNP cord-287815-alv30uk5 176 19 . . . cord-287815-alv30uk5 177 1 The the DT cord-287815-alv30uk5 177 2 need need NN cord-287815-alv30uk5 177 3 for for IN cord-287815-alv30uk5 177 4 this this DT cord-287815-alv30uk5 177 5 function function NN cord-287815-alv30uk5 177 6 is be VBZ cord-287815-alv30uk5 177 7 best well RBS cord-287815-alv30uk5 177 8 illustrated illustrate VBN cord-287815-alv30uk5 177 9 by by IN cord-287815-alv30uk5 177 10 considering consider VBG cord-287815-alv30uk5 177 11 the the DT cord-287815-alv30uk5 177 12 transport transport NN cord-287815-alv30uk5 177 13 and and CC cord-287815-alv30uk5 177 14 distribution distribution NN cord-287815-alv30uk5 177 15 of of IN cord-287815-alv30uk5 177 16 membrane membrane NN cord-287815-alv30uk5 177 17 lipids lipid NNS cord-287815-alv30uk5 177 18 through through IN cord-287815-alv30uk5 177 19 the the DT cord-287815-alv30uk5 177 20 Golgi Golgi NNP cord-287815-alv30uk5 177 21 . . . cord-287815-alv30uk5 178 1 Several several JJ cord-287815-alv30uk5 178 2 lipids lipid NNS cord-287815-alv30uk5 178 3 such such JJ cord-287815-alv30uk5 178 4 as as IN cord-287815-alv30uk5 178 5 cholesterol cholesterol NN cord-287815-alv30uk5 178 6 , , , cord-287815-alv30uk5 178 7 glycolipids glycolipid NNS cord-287815-alv30uk5 178 8 , , , cord-287815-alv30uk5 178 9 and and CC cord-287815-alv30uk5 178 10 sphingomyelin sphingomyelin NN cord-287815-alv30uk5 178 11 are be VBP cord-287815-alv30uk5 178 12 present present JJ cord-287815-alv30uk5 178 13 in in IN cord-287815-alv30uk5 178 14 very very RB cord-287815-alv30uk5 178 15 low low JJ cord-287815-alv30uk5 178 16 concentrations concentration NNS cord-287815-alv30uk5 178 17 in in IN cord-287815-alv30uk5 178 18 the the DT cord-287815-alv30uk5 178 19 ER er NN cord-287815-alv30uk5 178 20 , , , cord-287815-alv30uk5 178 21 although although IN cord-287815-alv30uk5 178 22 they -PRON- PRP cord-287815-alv30uk5 178 23 are be VBP cord-287815-alv30uk5 178 24 abundant abundant JJ cord-287815-alv30uk5 178 25 in in IN cord-287815-alv30uk5 178 26 the the DT cord-287815-alv30uk5 178 27 Golgi Golgi NNP cord-287815-alv30uk5 178 28 ( ( -LRB- cord-287815-alv30uk5 178 29 van van NNP cord-287815-alv30uk5 178 30 Meer Meer NNP cord-287815-alv30uk5 178 31 , , , cord-287815-alv30uk5 178 32 1989 1989 CD cord-287815-alv30uk5 178 33 ) ) -RRB- cord-287815-alv30uk5 178 34 . . . cord-287815-alv30uk5 179 1 If if IN cord-287815-alv30uk5 179 2 there there EX cord-287815-alv30uk5 179 3 were be VBD cord-287815-alv30uk5 179 4 lipid lipid NN cord-287815-alv30uk5 179 5 recycling recycling NN cord-287815-alv30uk5 179 6 from from IN cord-287815-alv30uk5 179 7 each each DT cord-287815-alv30uk5 179 8 Golgi Golgi NNP cord-287815-alv30uk5 179 9 compartment compartment NN cord-287815-alv30uk5 179 10 , , , cord-287815-alv30uk5 179 11 it -PRON- PRP cord-287815-alv30uk5 179 12 would would MD cord-287815-alv30uk5 179 13 be be VB cord-287815-alv30uk5 179 14 difficult difficult JJ cord-287815-alv30uk5 179 15 to to TO cord-287815-alv30uk5 179 16 account account VB cord-287815-alv30uk5 179 17 for for IN cord-287815-alv30uk5 179 18 these these DT cord-287815-alv30uk5 179 19 differences difference NNS cord-287815-alv30uk5 179 20 in in IN cord-287815-alv30uk5 179 21 lipid lipid NN cord-287815-alv30uk5 179 22 composition composition NN cord-287815-alv30uk5 179 23 . . . cord-287815-alv30uk5 180 1 Placing place VBG cord-287815-alv30uk5 180 2 a a DT cord-287815-alv30uk5 180 3 valve valve NN cord-287815-alv30uk5 180 4 in in IN cord-287815-alv30uk5 180 5 the the DT cord-287815-alv30uk5 180 6 pathway pathway NN cord-287815-alv30uk5 180 7 makes make VBZ cord-287815-alv30uk5 180 8 the the DT cord-287815-alv30uk5 180 9 lipid lipid NN cord-287815-alv30uk5 180 10 sorting sorting NN cord-287815-alv30uk5 180 11 problem problem NN cord-287815-alv30uk5 180 12 easier easy JJR cord-287815-alv30uk5 180 13 to to TO cord-287815-alv30uk5 180 14 solve solve VB cord-287815-alv30uk5 180 15 . . . cord-287815-alv30uk5 181 1 Several several JJ cord-287815-alv30uk5 181 2 studies study NNS cord-287815-alv30uk5 181 3 have have VBP cord-287815-alv30uk5 181 4 demonstrated demonstrate VBN cord-287815-alv30uk5 181 5 directly directly RB cord-287815-alv30uk5 181 6 that that IN cord-287815-alv30uk5 181 7 there there EX cord-287815-alv30uk5 181 8 is be VBZ cord-287815-alv30uk5 181 9 little little JJ cord-287815-alv30uk5 181 10 backflow backflow NN cord-287815-alv30uk5 181 11 of of IN cord-287815-alv30uk5 181 12 glycoproteins glycoprotein NNS cord-287815-alv30uk5 181 13 from from IN cord-287815-alv30uk5 181 14 the the DT cord-287815-alv30uk5 181 15 TGN TGN NNP cord-287815-alv30uk5 181 16 into into IN cord-287815-alv30uk5 181 17 proximal proximal JJ cord-287815-alv30uk5 181 18 Golgi Golgi NNP cord-287815-alv30uk5 181 19 compartments compartment NNS cord-287815-alv30uk5 181 20 ( ( -LRB- cord-287815-alv30uk5 181 21 Duncan Duncan NNP cord-287815-alv30uk5 181 22 and and CC cord-287815-alv30uk5 181 23 Kornfeld Kornfeld NNP cord-287815-alv30uk5 181 24 , , , cord-287815-alv30uk5 181 25 1988 1988 CD cord-287815-alv30uk5 181 26 ; ; : cord-287815-alv30uk5 181 27 Neefjes Neefjes NNP cord-287815-alv30uk5 181 28 et et NNP cord-287815-alv30uk5 181 29 al al NNP cord-287815-alv30uk5 181 30 . . NNP cord-287815-alv30uk5 181 31 , , , cord-287815-alv30uk5 181 32 1988 1988 CD cord-287815-alv30uk5 181 33 ; ; : cord-287815-alv30uk5 181 34 Chege Chege NNP cord-287815-alv30uk5 181 35 and and CC cord-287815-alv30uk5 181 36 Pfeffer Pfeffer NNP cord-287815-alv30uk5 181 37 , , , cord-287815-alv30uk5 181 38 1990 1990 CD cord-287815-alv30uk5 181 39 ) ) -RRB- cord-287815-alv30uk5 181 40 . . . cord-287815-alv30uk5 182 1 Also also RB cord-287815-alv30uk5 182 2 , , , cord-287815-alv30uk5 182 3 recycling recycling NN cord-287815-alv30uk5 182 4 of of IN cord-287815-alv30uk5 182 5 glycosphingolipids glycosphingolipid NNS cord-287815-alv30uk5 182 6 through through IN cord-287815-alv30uk5 182 7 the the DT cord-287815-alv30uk5 182 8 TGN TGN NNP cord-287815-alv30uk5 182 9 ( ( -LRB- cord-287815-alv30uk5 182 10 Schwartzmann Schwartzmann NNP cord-287815-alv30uk5 182 11 and and CC cord-287815-alv30uk5 182 12 Sandhoff Sandhoff NNP cord-287815-alv30uk5 182 13 , , , cord-287815-alv30uk5 182 14 1990 1990 CD cord-287815-alv30uk5 182 15 ) ) -RRB- cord-287815-alv30uk5 182 16 would would MD cord-287815-alv30uk5 182 17 be be VB cord-287815-alv30uk5 182 18 easier easy JJR cord-287815-alv30uk5 182 19 to to TO cord-287815-alv30uk5 182 20 explain explain VB cord-287815-alv30uk5 182 21 if if IN cord-287815-alv30uk5 182 22 these these DT cord-287815-alv30uk5 182 23 plasma plasma NN cord-287815-alv30uk5 182 24 membrane membrane NN cord-287815-alv30uk5 182 25 lipids lipid NNS cord-287815-alv30uk5 182 26 would would MD cord-287815-alv30uk5 182 27 not not RB cord-287815-alv30uk5 182 28 encouter encouter VB cord-287815-alv30uk5 182 29 medial medial JJ cord-287815-alv30uk5 182 30 Golgi Golgi NNP cord-287815-alv30uk5 182 31 enzymes enzyme NNS cord-287815-alv30uk5 182 32 ; ; : cord-287815-alv30uk5 182 33 otherwise otherwise RB cord-287815-alv30uk5 182 34 , , , cord-287815-alv30uk5 182 35 with with IN cord-287815-alv30uk5 182 36 time time NN cord-287815-alv30uk5 182 37 , , , cord-287815-alv30uk5 182 38 only only RB cord-287815-alv30uk5 182 39 complex complex JJ cord-287815-alv30uk5 182 40 glycolipids glycolipid NNS cord-287815-alv30uk5 182 41 would would MD cord-287815-alv30uk5 182 42 be be VB cord-287815-alv30uk5 182 43 present present JJ cord-287815-alv30uk5 182 44 on on IN cord-287815-alv30uk5 182 45 the the DT cord-287815-alv30uk5 182 46 cell cell NN cord-287815-alv30uk5 182 47 surface surface NN cord-287815-alv30uk5 182 48 . . . cord-287815-alv30uk5 183 1 Does do VBZ cord-287815-alv30uk5 183 2 Transport transport VB cord-287815-alv30uk5 183 3 through through IN cord-287815-alv30uk5 183 4 the the DT cord-287815-alv30uk5 183 5 Golgi Golgi NNP cord-287815-alv30uk5 183 6 Require Require NNP cord-287815-alv30uk5 183 7 Vesicular Vesicular NNP cord-287815-alv30uk5 183 8 Carriers carrier NNS cord-287815-alv30uk5 183 9 ? ? . cord-287815-alv30uk5 184 1 The the DT cord-287815-alv30uk5 184 2 second second JJ cord-287815-alv30uk5 184 3 key key JJ cord-287815-alv30uk5 184 4 element element NN cord-287815-alv30uk5 184 5 underlying underlie VBG cord-287815-alv30uk5 184 6 our -PRON- PRP$ cord-287815-alv30uk5 184 7 current current JJ cord-287815-alv30uk5 184 8 view view NN cord-287815-alv30uk5 184 9 of of IN cord-287815-alv30uk5 184 10 the the DT cord-287815-alv30uk5 184 11 Golgi Golgi NNP cord-287815-alv30uk5 184 12 concerns concern VBZ cord-287815-alv30uk5 184 13 the the DT cord-287815-alv30uk5 184 14 role role NN cord-287815-alv30uk5 184 15 of of IN cord-287815-alv30uk5 184 16 carrier carrier NN cord-287815-alv30uk5 184 17 vesicles vesicle NNS cord-287815-alv30uk5 184 18 in in IN cord-287815-alv30uk5 184 19 mediating mediate VBG cord-287815-alv30uk5 184 20 transport transport NN cord-287815-alv30uk5 184 21 through through IN cord-287815-alv30uk5 184 22 the the DT cord-287815-alv30uk5 184 23 Golgi Golgi NNP cord-287815-alv30uk5 184 24 complex complex NN cord-287815-alv30uk5 184 25 . . . cord-287815-alv30uk5 185 1 While while IN cord-287815-alv30uk5 185 2 transport transport NN cord-287815-alv30uk5 185 3 vesicles vesicle NNS cord-287815-alv30uk5 185 4 may may MD cord-287815-alv30uk5 185 5 represent represent VB cord-287815-alv30uk5 185 6 the the DT cord-287815-alv30uk5 185 7 most most RBS cord-287815-alv30uk5 185 8 likely likely JJ cord-287815-alv30uk5 185 9 mechanism mechanism NN cord-287815-alv30uk5 185 10 to to TO cord-287815-alv30uk5 185 11 accomplish accomplish VB cord-287815-alv30uk5 185 12 transfer transfer NN cord-287815-alv30uk5 185 13 between between IN cord-287815-alv30uk5 185 14 compartments compartment NNS cord-287815-alv30uk5 185 15 and/or and/or CC cord-287815-alv30uk5 185 16 individual individual JJ cord-287815-alv30uk5 185 17 cisternae cisternae NN cord-287815-alv30uk5 185 18 , , , cord-287815-alv30uk5 185 19 how how WRB cord-287815-alv30uk5 185 20 strong strong JJ cord-287815-alv30uk5 185 21 is be VBZ cord-287815-alv30uk5 185 22 the the DT cord-287815-alv30uk5 185 23 evidence evidence NN cord-287815-alv30uk5 185 24 that that IN cord-287815-alv30uk5 185 25 they -PRON- PRP cord-287815-alv30uk5 185 26 actually actually RB cord-287815-alv30uk5 185 27 perform perform VBP cord-287815-alv30uk5 185 28 this this DT cord-287815-alv30uk5 185 29 function function NN cord-287815-alv30uk5 185 30 ? ? . cord-287815-alv30uk5 186 1 In in IN cord-287815-alv30uk5 186 2 intact intact JJ cord-287815-alv30uk5 186 3 cells cell NNS cord-287815-alv30uk5 186 4 , , , cord-287815-alv30uk5 186 5 perhaps perhaps RB cord-287815-alv30uk5 186 6 the the DT cord-287815-alv30uk5 186 7 best good JJS cord-287815-alv30uk5 186 8 argument argument NN cord-287815-alv30uk5 186 9 comes come VBZ cord-287815-alv30uk5 186 10 from from IN cord-287815-alv30uk5 186 11 the the DT cord-287815-alv30uk5 186 12 early early JJ cord-287815-alv30uk5 186 13 cell cell NN cord-287815-alv30uk5 186 14 - - HYPH cord-287815-alv30uk5 186 15 cell cell NN cord-287815-alv30uk5 186 16 fusion fusion NN cord-287815-alv30uk5 186 17 experiments experiment NNS cord-287815-alv30uk5 186 18 of of IN cord-287815-alv30uk5 186 19 Rothman Rothman NNP cord-287815-alv30uk5 186 20 and and CC cord-287815-alv30uk5 186 21 colleagues colleague NNS cord-287815-alv30uk5 187 1 ( ( -LRB- cord-287815-alv30uk5 187 2 Rothman Rothman NNP cord-287815-alv30uk5 187 3 et et NNP cord-287815-alv30uk5 187 4 al al NNP cord-287815-alv30uk5 187 5 . . . cord-287815-alv30uk5 188 1 , , , cord-287815-alv30uk5 188 2 1984a 1984a CD cord-287815-alv30uk5 189 1 ( ( -LRB- cord-287815-alv30uk5 189 2 Rothman Rothman NNP cord-287815-alv30uk5 189 3 et et NNP cord-287815-alv30uk5 189 4 al al NNP cord-287815-alv30uk5 189 5 . . . cord-287815-alv30uk5 190 1 , , , cord-287815-alv30uk5 190 2 , , , cord-287815-alv30uk5 190 3 1984b 1984b CD cord-287815-alv30uk5 190 4 . . . cord-287815-alv30uk5 191 1 Here here RB cord-287815-alv30uk5 191 2 , , , cord-287815-alv30uk5 191 3 CHO CHO NNP cord-287815-alv30uk5 191 4 cell cell NN cord-287815-alv30uk5 191 5 glycosylation glycosylation NN cord-287815-alv30uk5 191 6 mutants mutant NNS cord-287815-alv30uk5 191 7 were be VBD cord-287815-alv30uk5 191 8 infected infect VBN cord-287815-alv30uk5 191 9 with with IN cord-287815-alv30uk5 191 10 VSV VSV NNP cord-287815-alv30uk5 191 11 and and CC cord-287815-alv30uk5 191 12 then then RB cord-287815-alv30uk5 191 13 fused fuse VBD cord-287815-alv30uk5 191 14 with with IN cord-287815-alv30uk5 191 15 uninfected uninfected JJ cord-287815-alv30uk5 191 16 cells cell NNS cord-287815-alv30uk5 191 17 . . . cord-287815-alv30uk5 192 1 Transfer transfer NN cord-287815-alv30uk5 192 2 of of IN cord-287815-alv30uk5 192 3 the the DT cord-287815-alv30uk5 192 4 VSV VSV NNP cord-287815-alv30uk5 192 5 G G NNP cord-287815-alv30uk5 192 6 protein protein NN cord-287815-alv30uk5 192 7 from from IN cord-287815-alv30uk5 192 8 Golgi Golgi NNP cord-287815-alv30uk5 192 9 membranes membrane NNS cord-287815-alv30uk5 192 10 in in IN cord-287815-alv30uk5 192 11 the the DT cord-287815-alv30uk5 192 12 infected infect VBN cord-287815-alv30uk5 192 13 to to IN cord-287815-alv30uk5 192 14 the the DT cord-287815-alv30uk5 192 15 uninfected uninfected JJ cord-287815-alv30uk5 192 16 cells cell NNS cord-287815-alv30uk5 192 17 was be VBD cord-287815-alv30uk5 192 18 monitored monitor VBN cord-287815-alv30uk5 192 19 by by IN cord-287815-alv30uk5 192 20 a a DT cord-287815-alv30uk5 192 21 glycosylation glycosylation NN cord-287815-alv30uk5 192 22 event event NN cord-287815-alv30uk5 192 23 that that WDT cord-287815-alv30uk5 192 24 could could MD cord-287815-alv30uk5 192 25 be be VB cord-287815-alv30uk5 192 26 carried carry VBN cord-287815-alv30uk5 192 27 out out RP cord-287815-alv30uk5 192 28 by by IN cord-287815-alv30uk5 192 29 only only RB cord-287815-alv30uk5 192 30 the the DT cord-287815-alv30uk5 192 31 uninfected uninfected JJ cord-287815-alv30uk5 192 32 recipient recipient NN cord-287815-alv30uk5 192 33 , , , cord-287815-alv30uk5 192 34 which which WDT cord-287815-alv30uk5 192 35 was be VBD cord-287815-alv30uk5 192 36 chosen choose VBN cord-287815-alv30uk5 192 37 to to TO cord-287815-alv30uk5 192 38 complement complement VB cord-287815-alv30uk5 192 39 the the DT cord-287815-alv30uk5 192 40 glycosylation glycosylation NN cord-287815-alv30uk5 192 41 defect defect NN cord-287815-alv30uk5 192 42 of of IN cord-287815-alv30uk5 192 43 the the DT cord-287815-alv30uk5 192 44 infected infected JJ cord-287815-alv30uk5 192 45 cell cell NN cord-287815-alv30uk5 192 46 . . . cord-287815-alv30uk5 193 1 These these DT cord-287815-alv30uk5 193 2 observations observation NNS cord-287815-alv30uk5 193 3 indicated indicate VBD cord-287815-alv30uk5 193 4 that that IN cord-287815-alv30uk5 193 5 efficient efficient JJ cord-287815-alv30uk5 193 6 transfer transfer NN cord-287815-alv30uk5 193 7 of of IN cord-287815-alv30uk5 193 8 VSV VSV NNP cord-287815-alv30uk5 193 9 G G NNP cord-287815-alv30uk5 193 10 protein protein NN cord-287815-alv30uk5 193 11 occurs occur VBZ cord-287815-alv30uk5 193 12 between between IN cord-287815-alv30uk5 193 13 spatially spatially RB cord-287815-alv30uk5 193 14 distinct distinct JJ cord-287815-alv30uk5 193 15 Golgi Golgi NNP cord-287815-alv30uk5 193 16 stacks stack NNS cord-287815-alv30uk5 193 17 . . . cord-287815-alv30uk5 194 1 This this DT cord-287815-alv30uk5 194 2 is be VBZ cord-287815-alv30uk5 194 3 most most RBS cord-287815-alv30uk5 194 4 easily easily RB cord-287815-alv30uk5 194 5 explained explain VBN cord-287815-alv30uk5 194 6 byamechanism byamechanism NN cord-287815-alv30uk5 194 7 involving involve VBG cord-287815-alv30uk5 194 8 VSVG VSVG NNP cord-287815-alv30uk5 194 9 proteincontaining proteincontaine VBG cord-287815-alv30uk5 194 10 transport transport NN cord-287815-alv30uk5 194 11 vesicles vesicle NNS cord-287815-alv30uk5 194 12 that that WDT cord-287815-alv30uk5 194 13 form form VBP cord-287815-alv30uk5 194 14 from from IN cord-287815-alv30uk5 194 15 the the DT cord-287815-alv30uk5 194 16 infected infected JJ cord-287815-alv30uk5 194 17 cell cell NN cord-287815-alv30uk5 194 18 Golgi golgi NN cord-287815-alv30uk5 194 19 , , , cord-287815-alv30uk5 194 20 diffuse diffuse VB cord-287815-alv30uk5 194 21 through through IN cord-287815-alv30uk5 194 22 the the DT cord-287815-alv30uk5 194 23 heterokaryon heterokaryon NN cord-287815-alv30uk5 194 24 's 's POS cord-287815-alv30uk5 194 25 cytosol cytosol NN cord-287815-alv30uk5 194 26 , , , cord-287815-alv30uk5 194 27 and and CC cord-287815-alv30uk5 194 28 fuse fuse VB cord-287815-alv30uk5 194 29 with with IN cord-287815-alv30uk5 194 30 Golgi Golgi NNP cord-287815-alv30uk5 194 31 membranes membrane NNS cord-287815-alv30uk5 194 32 in in IN cord-287815-alv30uk5 194 33 the the DT cord-287815-alv30uk5 194 34 uninfected uninfected JJ cord-287815-alv30uk5 194 35 cell cell NN cord-287815-alv30uk5 194 36 . . . cord-287815-alv30uk5 195 1 Conceivably conceivably RB cord-287815-alv30uk5 195 2 , , , cord-287815-alv30uk5 195 3 the the DT cord-287815-alv30uk5 195 4 same same JJ cord-287815-alv30uk5 195 5 transport transport NN cord-287815-alv30uk5 195 6 vesicles vesicle NNS cord-287815-alv30uk5 195 7 could could MD cord-287815-alv30uk5 195 8 mediate mediate VB cord-287815-alv30uk5 195 9 intercisternal intercisternal JJ cord-287815-alv30uk5 195 10 transport transport NN cord-287815-alv30uk5 195 11 within within IN cord-287815-alv30uk5 195 12 a a DT cord-287815-alv30uk5 195 13 single single JJ cord-287815-alv30uk5 195 14 Golgi Golgi NNP cord-287815-alv30uk5 195 15 stack stack NN cord-287815-alv30uk5 195 16 . . . cord-287815-alv30uk5 196 1 The the DT cord-287815-alv30uk5 196 2 major major JJ cord-287815-alv30uk5 196 3 limitation limitation NN cord-287815-alv30uk5 196 4 of of IN cord-287815-alv30uk5 196 5 these these DT cord-287815-alv30uk5 196 6 data datum NNS cord-287815-alv30uk5 196 7 is be VBZ cord-287815-alv30uk5 196 8 that that IN cord-287815-alv30uk5 196 9 they -PRON- PRP cord-287815-alv30uk5 196 10 are be VBP cord-287815-alv30uk5 196 11 indirect indirect JJ cord-287815-alv30uk5 196 12 . . . cord-287815-alv30uk5 197 1 They -PRON- PRP cord-287815-alv30uk5 197 2 do do VBP cord-287815-alv30uk5 197 3 not not RB cord-287815-alv30uk5 197 4 identify identify VB cord-287815-alv30uk5 197 5 the the DT cord-287815-alv30uk5 197 6 vesicles vesicle NNS cord-287815-alv30uk5 197 7 nor nor CC cord-287815-alv30uk5 197 8 do do VBP cord-287815-alv30uk5 197 9 they -PRON- PRP cord-287815-alv30uk5 197 10 definitely definitely RB cord-287815-alv30uk5 197 11 establish establish VB cord-287815-alv30uk5 197 12 their -PRON- PRP$ cord-287815-alv30uk5 197 13 site site NN cord-287815-alv30uk5 197 14 of of IN cord-287815-alv30uk5 197 15 origin origin NN cord-287815-alv30uk5 197 16 . . . cord-287815-alv30uk5 198 1 One one PRP cord-287815-alv30uk5 198 2 can can MD cord-287815-alv30uk5 198 3 not not RB cord-287815-alv30uk5 198 4 exclude exclude VB cord-287815-alv30uk5 198 5 the the DT cord-287815-alv30uk5 198 6 possibility possibility NN cord-287815-alv30uk5 198 7 that that IN cord-287815-alv30uk5 198 8 the the DT cord-287815-alv30uk5 198 9 G G NNP cord-287815-alv30uk5 198 10 protein protein NN cord-287815-alv30uk5 198 11 moved move VBN cord-287815-alv30uk5 198 12 by by IN cord-287815-alv30uk5 198 13 lateral lateral JJ cord-287815-alv30uk5 198 14 diffusion diffusion NN cord-287815-alv30uk5 198 15 through through IN cord-287815-alv30uk5 198 16 tubules tubule NNS cord-287815-alv30uk5 198 17 connecting connect VBG cord-287815-alv30uk5 198 18 the the DT cord-287815-alv30uk5 198 19 heterologous heterologous JJ cord-287815-alv30uk5 198 20 Golgi Golgi NNP cord-287815-alv30uk5 198 21 stacks stack NNS cord-287815-alv30uk5 198 22 , , , cord-287815-alv30uk5 198 23 which which WDT cord-287815-alv30uk5 198 24 otherwise otherwise RB cord-287815-alv30uk5 198 25 remain remain VBP cord-287815-alv30uk5 198 26 separated separated JJ cord-287815-alv30uk5 198 27 during during IN cord-287815-alv30uk5 198 28 the the DT cord-287815-alv30uk5 198 29 assay assay NN cord-287815-alv30uk5 198 30 . . . cord-287815-alv30uk5 199 1 Furthermore furthermore RB cord-287815-alv30uk5 199 2 , , , cord-287815-alv30uk5 199 3 even even RB cord-287815-alv30uk5 199 4 the the DT cord-287815-alv30uk5 199 5 existence existence NN cord-287815-alv30uk5 199 6 of of IN cord-287815-alv30uk5 199 7 vesicles vesicle NNS cord-287815-alv30uk5 199 8 involved involve VBN cord-287815-alv30uk5 199 9 in in IN cord-287815-alv30uk5 199 10 inter inter JJ cord-287815-alv30uk5 199 11 - - JJ cord-287815-alv30uk5 199 12 Golgi golgi JJ cord-287815-alv30uk5 199 13 transport transport NN cord-287815-alv30uk5 199 14 does do VBZ cord-287815-alv30uk5 199 15 not not RB cord-287815-alv30uk5 199 16 demonstrate demonstrate VB cord-287815-alv30uk5 199 17 that that IN cord-287815-alv30uk5 199 18 they -PRON- PRP cord-287815-alv30uk5 199 19 have have VBP cord-287815-alv30uk5 199 20 a a DT cord-287815-alv30uk5 199 21 similar similar JJ cord-287815-alv30uk5 199 22 role role NN cord-287815-alv30uk5 199 23 in in IN cord-287815-alv30uk5 199 24 intercisternal intercisternal JJ cord-287815-alv30uk5 199 25 transport transport NN cord-287815-alv30uk5 199 26 within within IN cord-287815-alv30uk5 199 27 a a DT cord-287815-alv30uk5 199 28 single single JJ cord-287815-alv30uk5 199 29 stack stack NN cord-287815-alv30uk5 199 30 , , , cord-287815-alv30uk5 199 31 as as IN cord-287815-alv30uk5 199 32 is be VBZ cord-287815-alv30uk5 199 33 assumed assume VBN cord-287815-alv30uk5 199 34 by by IN cord-287815-alv30uk5 199 35 our -PRON- PRP$ cord-287815-alv30uk5 199 36 current current JJ cord-287815-alv30uk5 199 37 view view NN cord-287815-alv30uk5 199 38 of of IN cord-287815-alv30uk5 199 39 the the DT cord-287815-alv30uk5 199 40 Golgi Golgi NNP cord-287815-alv30uk5 199 41 . . . cord-287815-alv30uk5 200 1 In in IN cord-287815-alv30uk5 200 2 Vitro Vitro NNP cord-287815-alv30uk5 200 3 Transport Transport NNP cord-287815-alv30uk5 200 4 through through IN cord-287815-alv30uk5 200 5 the the DT cord-287815-alv30uk5 200 6 Golgi Golgi NNP cord-287815-alv30uk5 200 7 and and CC cord-287815-alv30uk5 200 8 the the DT cord-287815-alv30uk5 200 9 Role role NN cord-287815-alv30uk5 200 10 of of IN cord-287815-alv30uk5 200 11 Carrier Carrier NNP cord-287815-alv30uk5 200 12 Vesicles Vesicles NNP cord-287815-alv30uk5 201 1 The the DT cord-287815-alv30uk5 201 2 most most RBS cord-287815-alv30uk5 201 3 extensive extensive JJ cord-287815-alv30uk5 201 4 series series NN cord-287815-alv30uk5 201 5 of of IN cord-287815-alv30uk5 201 6 considerations consideration NNS cord-287815-alv30uk5 201 7 favoring favor VBG cord-287815-alv30uk5 201 8 the the DT cord-287815-alv30uk5 201 9 role role NN cord-287815-alv30uk5 201 10 of of IN cord-287815-alv30uk5 201 11 transport transport NN cord-287815-alv30uk5 201 12 vesicles vesicle NNS cord-287815-alv30uk5 201 13 in in IN cord-287815-alv30uk5 201 14 intra intra JJ cord-287815-alv30uk5 201 15 - - JJ cord-287815-alv30uk5 201 16 Golgi golgi JJ cord-287815-alv30uk5 201 17 transport transport NN cord-287815-alv30uk5 201 18 comes come VBZ cord-287815-alv30uk5 201 19 from from IN cord-287815-alv30uk5 201 20 experiments experiment NNS cord-287815-alv30uk5 201 21 designed design VBN cord-287815-alv30uk5 201 22 to to TO cord-287815-alv30uk5 201 23 reconstitute reconstitute VB cord-287815-alv30uk5 201 24 transport transport NN cord-287815-alv30uk5 201 25 in in IN cord-287815-alv30uk5 201 26 vitro vitro FW cord-287815-alv30uk5 201 27 . . . cord-287815-alv30uk5 202 1 That that IN cord-287815-alv30uk5 202 2 such such JJ cord-287815-alv30uk5 202 3 transport transport NN cord-287815-alv30uk5 202 4 can can MD cord-287815-alv30uk5 202 5 be be VB cord-287815-alv30uk5 202 6 achieved achieve VBN cord-287815-alv30uk5 202 7 has have VBZ cord-287815-alv30uk5 202 8 been be VBN cord-287815-alv30uk5 202 9 demonstrated demonstrate VBN cord-287815-alv30uk5 202 10 over over IN cord-287815-alv30uk5 202 11 the the DT cord-287815-alv30uk5 202 12 past past JJ cord-287815-alv30uk5 202 13 several several JJ cord-287815-alv30uk5 202 14 years year NNS cord-287815-alv30uk5 202 15 by by IN cord-287815-alv30uk5 202 16 the the DT cord-287815-alv30uk5 202 17 pioneering pioneering JJ cord-287815-alv30uk5 202 18 work work NN cord-287815-alv30uk5 202 19 of of IN cord-287815-alv30uk5 202 20 Rothman Rothman NNP cord-287815-alv30uk5 202 21 and and CC cord-287815-alv30uk5 202 22 coworkers coworker NNS cord-287815-alv30uk5 202 23 . . . cord-287815-alv30uk5 203 1 In in IN cord-287815-alv30uk5 203 2 their -PRON- PRP$ cord-287815-alv30uk5 203 3 approach approach NN cord-287815-alv30uk5 203 4 , , , cord-287815-alv30uk5 203 5 Golgi Golgi NNP cord-287815-alv30uk5 203 6 fractions fraction NNS cord-287815-alv30uk5 203 7 prepared prepare VBN cord-287815-alv30uk5 203 8 from from IN cord-287815-alv30uk5 203 9 VSV VSV NNP cord-287815-alv30uk5 203 10 - - HYPH cord-287815-alv30uk5 203 11 infected infect VBN cord-287815-alv30uk5 203 12 GlcNAc GlcNAc NNP cord-287815-alv30uk5 203 13 transferase transferase NN cord-287815-alv30uk5 203 14 - - HYPH cord-287815-alv30uk5 203 15 deficient deficient JJ cord-287815-alv30uk5 203 16 158 158 CD cord-287815-alv30uk5 203 17 cells cell NNS cord-287815-alv30uk5 203 18 ( ( -LRB- cord-287815-alv30uk5 203 19 " " `` cord-287815-alv30uk5 203 20 donor donor NN cord-287815-alv30uk5 203 21 Golgi Golgi NNP cord-287815-alv30uk5 203 22 " " '' cord-287815-alv30uk5 203 23 ) ) -RRB- cord-287815-alv30uk5 203 24 are be VBP cord-287815-alv30uk5 203 25 incubated incubate VBN cord-287815-alv30uk5 203 26 with with IN cord-287815-alv30uk5 203 27 similar similar JJ cord-287815-alv30uk5 203 28 fractions fraction NNS cord-287815-alv30uk5 203 29 from from IN cord-287815-alv30uk5 203 30 uninfected uninfected JJ cord-287815-alv30uk5 203 31 wild wild JJ cord-287815-alv30uk5 203 32 - - HYPH cord-287815-alv30uk5 203 33 type type NN cord-287815-alv30uk5 203 34 cells cell NNS cord-287815-alv30uk5 203 35 ( ( -LRB- cord-287815-alv30uk5 203 36 ' ' `` cord-287815-alv30uk5 203 37 acceptor acceptor NN cord-287815-alv30uk5 203 38 Golgi Golgi NNP cord-287815-alv30uk5 203 39 " " '' cord-287815-alv30uk5 203 40 ) ) -RRB- cord-287815-alv30uk5 203 41 . . . cord-287815-alv30uk5 204 1 Upon upon IN cord-287815-alv30uk5 204 2 the the DT cord-287815-alv30uk5 204 3 addition addition NN cord-287815-alv30uk5 204 4 of of IN cord-287815-alv30uk5 204 5 ATP ATP NNP cord-287815-alv30uk5 204 6 and and CC cord-287815-alv30uk5 204 7 cytosolderived cytosolderive VBN cord-287815-alv30uk5 204 8 factors factor NNS cord-287815-alv30uk5 204 9 , , , cord-287815-alv30uk5 204 10 there there EX cord-287815-alv30uk5 204 11 is be VBZ cord-287815-alv30uk5 204 12 a a DT cord-287815-alv30uk5 204 13 progressive progressive JJ cord-287815-alv30uk5 204 14 appearance appearance NN cord-287815-alv30uk5 204 15 of of IN cord-287815-alv30uk5 204 16 [ [ -LRB- cord-287815-alv30uk5 204 17 3H]GlcNAc 3h]glcnac CD cord-287815-alv30uk5 204 18 - - HYPH cord-287815-alv30uk5 204 19 labeled label VBN cord-287815-alv30uk5 204 20 ( ( -LRB- cord-287815-alv30uk5 204 21 Balch Balch NNP cord-287815-alv30uk5 204 22 et et NNP cord-287815-alv30uk5 204 23 al al NNP cord-287815-alv30uk5 204 24 . . NNP cord-287815-alv30uk5 204 25 , , , cord-287815-alv30uk5 204 26 1984 1984 CD cord-287815-alv30uk5 204 27 ) ) -RRB- cord-287815-alv30uk5 205 1 and and CC cord-287815-alv30uk5 205 2 endo endo NNP cord-287815-alv30uk5 205 3 H H NNP cord-287815-alv30uk5 205 4 - - HYPH cord-287815-alv30uk5 205 5 resistant resistant JJ cord-287815-alv30uk5 206 1 ( ( -LRB- cord-287815-alv30uk5 206 2 Fries Fries NNP cord-287815-alv30uk5 206 3 and and CC cord-287815-alv30uk5 206 4 Rothman Rothman NNP cord-287815-alv30uk5 206 5 , , , cord-287815-alv30uk5 206 6 1981 1981 CD cord-287815-alv30uk5 206 7 ) ) -RRB- cord-287815-alv30uk5 207 1 VSV VSV NNP cord-287815-alv30uk5 207 2 G G NNP cord-287815-alv30uk5 207 3 protein protein NN cord-287815-alv30uk5 207 4 , , , cord-287815-alv30uk5 207 5 reflecting reflect VBG cord-287815-alv30uk5 207 6 its -PRON- PRP$ cord-287815-alv30uk5 207 7 transfer transfer NN cord-287815-alv30uk5 207 8 from from IN cord-287815-alv30uk5 207 9 mutant mutant JJ cord-287815-alv30uk5 207 10 " " `` cord-287815-alv30uk5 207 11 donor donor NN cord-287815-alv30uk5 207 12 " " '' cord-287815-alv30uk5 207 13 to to IN cord-287815-alv30uk5 207 14 wild wild JJ cord-287815-alv30uk5 207 15 - - HYPH cord-287815-alv30uk5 207 16 type type NN cord-287815-alv30uk5 207 17 " " `` cord-287815-alv30uk5 207 18 acceptor acceptor NN cord-287815-alv30uk5 207 19 " " '' cord-287815-alv30uk5 207 20 membranes membrane NNS cord-287815-alv30uk5 207 21 . . . cord-287815-alv30uk5 208 1 This this DT cord-287815-alv30uk5 208 2 transfer transfer NN cord-287815-alv30uk5 208 3 has have VBZ cord-287815-alv30uk5 208 4 also also RB cord-287815-alv30uk5 208 5 been be VBN cord-287815-alv30uk5 208 6 dissected dissect VBN cord-287815-alv30uk5 208 7 kinetically kinetically RB cord-287815-alv30uk5 208 8 into into IN cord-287815-alv30uk5 208 9 two two CD cord-287815-alv30uk5 208 10 major major JJ cord-287815-alv30uk5 208 11 stages stage NNS cord-287815-alv30uk5 208 12 : : : cord-287815-alv30uk5 208 13 an an DT cord-287815-alv30uk5 208 14 early early JJ cord-287815-alv30uk5 208 15 stage stage NN cord-287815-alv30uk5 208 16 presumed presume VBN cord-287815-alv30uk5 208 17 to to TO cord-287815-alv30uk5 208 18 correlate correlate VB cord-287815-alv30uk5 208 19 with with IN cord-287815-alv30uk5 208 20 the the DT cord-287815-alv30uk5 208 21 budding budding NN cord-287815-alv30uk5 208 22 of of IN cord-287815-alv30uk5 208 23 transport transport NN cord-287815-alv30uk5 208 24 vesicles vesicle NNS cord-287815-alv30uk5 208 25 from from IN cord-287815-alv30uk5 208 26 the the DT cord-287815-alv30uk5 208 27 donor donor NN cord-287815-alv30uk5 208 28 Golgi Golgi NNP cord-287815-alv30uk5 208 29 , , , cord-287815-alv30uk5 208 30 and and CC cord-287815-alv30uk5 208 31 a a DT cord-287815-alv30uk5 208 32 late late JJ cord-287815-alv30uk5 208 33 stage stage NN cord-287815-alv30uk5 208 34 reflecting reflect VBG cord-287815-alv30uk5 208 35 the the DT cord-287815-alv30uk5 208 36 docking docking NN cord-287815-alv30uk5 208 37 and and CC cord-287815-alv30uk5 208 38 subsequent subsequent JJ cord-287815-alv30uk5 208 39 fusion fusion NN cord-287815-alv30uk5 208 40 of of IN cord-287815-alv30uk5 208 41 the the DT cord-287815-alv30uk5 208 42 vesicles vesicle NNS cord-287815-alv30uk5 208 43 with with IN cord-287815-alv30uk5 208 44 the the DT cord-287815-alv30uk5 208 45 acceptor acceptor NN cord-287815-alv30uk5 208 46 Golgi Golgi NNP cord-287815-alv30uk5 208 47 . . . cord-287815-alv30uk5 209 1 The the DT cord-287815-alv30uk5 209 2 early early JJ cord-287815-alv30uk5 209 3 and and CC cord-287815-alv30uk5 209 4 late late JJ cord-287815-alv30uk5 209 5 stages stage NNS cord-287815-alv30uk5 209 6 also also RB cord-287815-alv30uk5 209 7 differ differ VBP cord-287815-alv30uk5 209 8 in in IN cord-287815-alv30uk5 209 9 their -PRON- PRP$ cord-287815-alv30uk5 209 10 requirements requirement NNS cord-287815-alv30uk5 209 11 and and CC cord-287815-alv30uk5 209 12 inhibitor inhibitor NN cord-287815-alv30uk5 209 13 sensitivities sensitivity NNS cord-287815-alv30uk5 209 14 ( ( -LRB- cord-287815-alv30uk5 209 15 Balch Balch NNP cord-287815-alv30uk5 209 16 et et NNP cord-287815-alv30uk5 209 17 al al NNP cord-287815-alv30uk5 209 18 . . NNP cord-287815-alv30uk5 209 19 , , , cord-287815-alv30uk5 209 20 1984 1984 CD cord-287815-alv30uk5 209 21 ; ; : cord-287815-alv30uk5 209 22 Rothman Rothman NNP cord-287815-alv30uk5 209 23 and and CC cord-287815-alv30uk5 209 24 Orci Orci NNP cord-287815-alv30uk5 209 25 , , , cord-287815-alv30uk5 209 26 1990 1990 CD cord-287815-alv30uk5 209 27 ) ) -RRB- cord-287815-alv30uk5 209 28 . . . cord-287815-alv30uk5 210 1 Given give VBN cord-287815-alv30uk5 210 2 that that IN cord-287815-alv30uk5 210 3 VSV VSV NNP cord-287815-alv30uk5 210 4 G G NNP cord-287815-alv30uk5 210 5 protein protein NN cord-287815-alv30uk5 210 6 in in IN cord-287815-alv30uk5 210 7 early early JJ cord-287815-alv30uk5 210 8 Golgi Golgi NNP cord-287815-alv30uk5 210 9 compartments compartment NNS cord-287815-alv30uk5 210 10 was be VBD cord-287815-alv30uk5 210 11 transported transport VBN cord-287815-alv30uk5 210 12 with with IN cord-287815-alv30uk5 210 13 the the DT cord-287815-alv30uk5 210 14 highest high JJS cord-287815-alv30uk5 210 15 efficiency efficiency NN cord-287815-alv30uk5 210 16 ( ( -LRB- cord-287815-alv30uk5 210 17 Fries Fries NNP cord-287815-alv30uk5 210 18 and and CC cord-287815-alv30uk5 210 19 Rothman Rothman NNP cord-287815-alv30uk5 210 20 , , , cord-287815-alv30uk5 210 21 1981 1981 CD cord-287815-alv30uk5 210 22 ) ) -RRB- cord-287815-alv30uk5 211 1 the the DT cord-287815-alv30uk5 211 2 transport transport NN cord-287815-alv30uk5 211 3 event event NN cord-287815-alv30uk5 211 4 assayed assay VBN cord-287815-alv30uk5 211 5 was be VBD cord-287815-alv30uk5 211 6 postulated postulate VBN cord-287815-alv30uk5 211 7 to to TO cord-287815-alv30uk5 211 8 reflect reflect VB cord-287815-alv30uk5 211 9 the the DT cord-287815-alv30uk5 211 10 formation formation NN cord-287815-alv30uk5 211 11 of of IN cord-287815-alv30uk5 211 12 vesicles vesicle NNS cord-287815-alv30uk5 211 13 from from IN cord-287815-alv30uk5 211 14 cis cis NNP cord-287815-alv30uk5 211 15 ( ( -LRB- cord-287815-alv30uk5 211 16 early early JJ cord-287815-alv30uk5 211 17 ) ) -RRB- cord-287815-alv30uk5 211 18 cisternae cisternae NNP cord-287815-alv30uk5 211 19 and and CC cord-287815-alv30uk5 211 20 the the DT cord-287815-alv30uk5 211 21 fusion fusion NN cord-287815-alv30uk5 211 22 of of IN cord-287815-alv30uk5 211 23 these these DT cord-287815-alv30uk5 211 24 vesicles vesicle NNS cord-287815-alv30uk5 211 25 with with IN cord-287815-alv30uk5 211 26 medial medial JJ cord-287815-alv30uk5 211 27 cisternae cisternae NN cord-287815-alv30uk5 211 28 ( ( -LRB- cord-287815-alv30uk5 211 29 which which WDT cord-287815-alv30uk5 211 30 contain contain VBP cord-287815-alv30uk5 211 31 the the DT cord-287815-alv30uk5 211 32 GlcNAc GlcNAc NNP cord-287815-alv30uk5 211 33 transferase transferase NN cord-287815-alv30uk5 211 34 ) ) -RRB- cord-287815-alv30uk5 212 1 ( ( -LRB- cord-287815-alv30uk5 212 2 Rothman Rothman NNP cord-287815-alv30uk5 212 3 and and CC cord-287815-alv30uk5 212 4 Orci Orci NNP cord-287815-alv30uk5 212 5 , , , cord-287815-alv30uk5 212 6 1990 1990 CD cord-287815-alv30uk5 212 7 ) ) -RRB- cord-287815-alv30uk5 213 1 ( ( -LRB- cord-287815-alv30uk5 213 2 Figure figure NN cord-287815-alv30uk5 213 3 4 4 CD cord-287815-alv30uk5 213 4 ) ) -RRB- cord-287815-alv30uk5 213 5 . . . cord-287815-alv30uk5 214 1 However however RB cord-287815-alv30uk5 214 2 , , , cord-287815-alv30uk5 214 3 the the DT cord-287815-alv30uk5 214 4 identi identi JJ cord-287815-alv30uk5 214 5 - - HYPH cord-287815-alv30uk5 214 6 DONOR DONOR NNP cord-287815-alv30uk5 214 7 ACCEPTOR ACCEPTOR NNP cord-287815-alv30uk5 214 8 Fllgure Fllgure NNP cord-287815-alv30uk5 214 9 4 4 CD cord-287815-alv30uk5 214 10 . . . cord-287815-alv30uk5 215 1 Two two CD cord-287815-alv30uk5 215 2 Models model NNS cord-287815-alv30uk5 215 3 to to TO cord-287815-alv30uk5 215 4 Account account VB cord-287815-alv30uk5 215 5 for for IN cord-287815-alv30uk5 215 6 Donor Donor NNP cord-287815-alv30uk5 215 7 - - HYPH cord-287815-alv30uk5 215 8 Acceptor Acceptor NNP cord-287815-alv30uk5 215 9 Connections Connections NNPS cord-287815-alv30uk5 215 10 in in IN cord-287815-alv30uk5 215 11 Inter Inter NNP cord-287815-alv30uk5 215 12 - - HYPH cord-287815-alv30uk5 215 13 Golgi Golgi NNP cord-287815-alv30uk5 215 14 Transport Transport NNP cord-287815-alv30uk5 216 1 In in IN cord-287815-alv30uk5 216 2 Vitro Vitro NNP cord-287815-alv30uk5 216 3 ( ( -LRB- cord-287815-alv30uk5 216 4 A A NNP cord-287815-alv30uk5 216 5 ) ) -RRB- cord-287815-alv30uk5 216 6 Vesicular vesicular JJ cord-287815-alv30uk5 216 7 transport transport NN cord-287815-alv30uk5 216 8 , , , cord-287815-alv30uk5 216 9 as as IN cord-287815-alv30uk5 216 10 predicted predict VBN cord-287815-alv30uk5 216 11 by by IN cord-287815-alv30uk5 216 12 the the DT cord-287815-alv30uk5 216 13 current current JJ cord-287815-alv30uk5 216 14 view view NN cord-287815-alv30uk5 216 15 of of IN cord-287815-alv30uk5 216 16 the the DT cord-287815-alv30uk5 216 17 Golgi Golgi NNP cord-287815-alv30uk5 216 18 alid alid NN cord-287815-alv30uk5 216 19 by by IN cord-287815-alv30uk5 216 20 the the DT cord-287815-alv30uk5 216 21 work work NN cord-287815-alv30uk5 216 22 of of IN cord-287815-alv30uk5 216 23 Rothman Rothman NNP cord-287815-alv30uk5 216 24 and and CC cord-287815-alv30uk5 216 25 colleagues colleague NNS cord-287815-alv30uk5 216 26 ( ( -LRB- cord-287815-alv30uk5 216 27 Rothman Rothman NNP cord-287815-alv30uk5 216 28 and and CC cord-287815-alv30uk5 216 29 Orci Orci NNP cord-287815-alv30uk5 216 30 . . . cord-287815-alv30uk5 216 31 1990 1990 CD cord-287815-alv30uk5 216 32 ) ) -RRB- cord-287815-alv30uk5 216 33 . . . cord-287815-alv30uk5 217 1 ( ( -LRB- cord-287815-alv30uk5 217 2 ES ES NNP cord-287815-alv30uk5 217 3 ) ) -RRB- cord-287815-alv30uk5 217 4 Vesicle Vesicle NNP cord-287815-alv30uk5 217 5 - - HYPH cord-287815-alv30uk5 217 6 independent independent JJ cord-287815-alv30uk5 217 7 direct direct JJ cord-287815-alv30uk5 217 8 fusions fusion NNS cord-287815-alv30uk5 217 9 between between IN cord-287815-alv30uk5 217 10 donor donor NN cord-287815-alv30uk5 217 11 and and CC cord-287815-alv30uk5 217 12 acceptor acceptor NN cord-287815-alv30uk5 217 13 compartments compartment NNS cord-287815-alv30uk5 217 14 ( ( -LRB- cord-287815-alv30uk5 217 15 CGN CGN NNP cord-287815-alv30uk5 217 16 - - HYPH cord-287815-alv30uk5 217 17 CGN CGN NNP cord-287815-alv30uk5 217 18 , , , cord-287815-alv30uk5 217 19 medial medial JJ cord-287815-alv30uk5 217 20 - - HYPH cord-287815-alv30uk5 217 21 medial medial JJ cord-287815-alv30uk5 217 22 , , , cord-287815-alv30uk5 217 23 and and CC cord-287815-alv30uk5 217 24 TGN TGN NNP cord-287815-alv30uk5 217 25 - - HYPH cord-287815-alv30uk5 217 26 TGN TGN NNP cord-287815-alv30uk5 217 27 ) ) -RRB- cord-287815-alv30uk5 217 28 , , , cord-287815-alv30uk5 217 29 perhaps perhaps RB cord-287815-alv30uk5 217 30 mediated mediate VBN cord-287815-alv30uk5 217 31 by by IN cord-287815-alv30uk5 217 32 tubular tubular JJ cord-287815-alv30uk5 217 33 extensions extension NNS cord-287815-alv30uk5 217 34 . . . cord-287815-alv30uk5 218 1 While while IN cord-287815-alv30uk5 218 2 these these DT cord-287815-alv30uk5 218 3 tubules tubule NNS cord-287815-alv30uk5 218 4 may may MD cord-287815-alv30uk5 218 5 be be VB cord-287815-alv30uk5 218 6 amplified amplify VBN cord-287815-alv30uk5 218 7 by by IN cord-287815-alv30uk5 218 8 BFA BFA NNP cord-287815-alv30uk5 218 9 . . . cord-287815-alv30uk5 219 1 as as IN cord-287815-alv30uk5 219 2 described describe VBN cord-287815-alv30uk5 219 3 in in IN cord-287815-alv30uk5 219 4 the the DT cord-287815-alv30uk5 219 5 text text NN cord-287815-alv30uk5 219 6 , , , cord-287815-alv30uk5 219 7 they -PRON- PRP cord-287815-alv30uk5 219 8 may may MD cord-287815-alv30uk5 219 9 exist exist VB cord-287815-alv30uk5 219 10 and and CC cord-287815-alv30uk5 219 11 function function VB cord-287815-alv30uk5 219 12 even even RB cord-287815-alv30uk5 219 13 in in IN cord-287815-alv30uk5 219 14 the the DT cord-287815-alv30uk5 219 15 absence absence NN cord-287815-alv30uk5 219 16 of of IN cord-287815-alv30uk5 219 17 the the DT cord-287815-alv30uk5 219 18 drug drug NN cord-287815-alv30uk5 219 19 . . . cord-287815-alv30uk5 220 1 ties tie NNS cord-287815-alv30uk5 220 2 of of IN cord-287815-alv30uk5 220 3 the the DT cord-287815-alv30uk5 220 4 donor donor NN cord-287815-alv30uk5 220 5 and and CC cord-287815-alv30uk5 220 6 acceptor acceptor NN cord-287815-alv30uk5 220 7 cisternae cisternae NNP cord-287815-alv30uk5 220 8 have have VBP cord-287815-alv30uk5 220 9 not not RB cord-287815-alv30uk5 220 10 yet yet RB cord-287815-alv30uk5 220 11 been be VBN cord-287815-alv30uk5 220 12 established establish VBN cord-287815-alv30uk5 220 13 , , , cord-287815-alv30uk5 220 14 nor nor CC cord-287815-alv30uk5 220 15 can can MD cord-287815-alv30uk5 220 16 kinetic kinetic JJ cord-287815-alv30uk5 220 17 analysis analysis NN cord-287815-alv30uk5 220 18 alone alone RB cord-287815-alv30uk5 220 19 provide provide VBP cord-287815-alv30uk5 220 20 a a DT cord-287815-alv30uk5 220 21 unique unique JJ cord-287815-alv30uk5 220 22 interpretation interpretation NN cord-287815-alv30uk5 220 23 , , , cord-287815-alv30uk5 220 24 especially especially RB cord-287815-alv30uk5 220 25 when when WRB cord-287815-alv30uk5 220 26 transport transport NN cord-287815-alv30uk5 220 27 is be VBZ cord-287815-alv30uk5 220 28 monitored monitor VBN cord-287815-alv30uk5 220 29 indirectly indirectly RB cord-287815-alv30uk5 220 30 by by IN cord-287815-alv30uk5 220 31 linkage linkage NN cord-287815-alv30uk5 220 32 to to IN cord-287815-alv30uk5 220 33 glycosylation glycosylation NN cord-287815-alv30uk5 220 34 , , , cord-287815-alv30uk5 220 35 which which WDT cord-287815-alv30uk5 220 36 itself -PRON- PRP cord-287815-alv30uk5 220 37 is be VBZ cord-287815-alv30uk5 220 38 a a DT cord-287815-alv30uk5 220 39 kinetically kinetically RB cord-287815-alv30uk5 220 40 complex complex JJ cord-287815-alv30uk5 220 41 series series NN cord-287815-alv30uk5 220 42 of of IN cord-287815-alv30uk5 220 43 reactions reaction NNS cord-287815-alv30uk5 220 44 ( ( -LRB- cord-287815-alv30uk5 220 45 see see VB cord-287815-alv30uk5 220 46 above above RB cord-287815-alv30uk5 220 47 ) ) -RRB- cord-287815-alv30uk5 220 48 . . . cord-287815-alv30uk5 221 1 Analysis analysis NN cord-287815-alv30uk5 221 2 of of IN cord-287815-alv30uk5 221 3 this this DT cord-287815-alv30uk5 221 4 Golgi Golgi NNP cord-287815-alv30uk5 221 5 transport transport NN cord-287815-alv30uk5 221 6 system system NN cord-287815-alv30uk5 221 7 has have VBZ cord-287815-alv30uk5 221 8 already already RB cord-287815-alv30uk5 221 9 led lead VBN cord-287815-alv30uk5 221 10 to to IN cord-287815-alv30uk5 221 11 the the DT cord-287815-alv30uk5 221 12 discovery discovery NN cord-287815-alv30uk5 221 13 of of IN cord-287815-alv30uk5 221 14 several several JJ cord-287815-alv30uk5 221 15 discrete discrete JJ cord-287815-alv30uk5 221 16 protein protein NN cord-287815-alv30uk5 221 17 factors factor NNS cord-287815-alv30uk5 221 18 whose whose WP$ cord-287815-alv30uk5 221 19 a.ctivities a.ctivitie NNS cord-287815-alv30uk5 221 20 are be VBP cord-287815-alv30uk5 221 21 required require VBN cord-287815-alv30uk5 221 22 to to TO cord-287815-alv30uk5 221 23 mediate mediate VB cord-287815-alv30uk5 221 24 the the DT cord-287815-alv30uk5 221 25 assay assay NN cord-287815-alv30uk5 221 26 ( ( -LRB- cord-287815-alv30uk5 221 27 Rothman Rothman NNP cord-287815-alv30uk5 221 28 and and CC cord-287815-alv30uk5 221 29 Orci Orci NNP cord-287815-alv30uk5 221 30 , , , cord-287815-alv30uk5 221 31 1990 1990 CD cord-287815-alv30uk5 221 32 ) ) -RRB- cord-287815-alv30uk5 221 33 . . . cord-287815-alv30uk5 222 1 Some some DT cord-287815-alv30uk5 222 2 of of IN cord-287815-alv30uk5 222 3 these these DT cord-287815-alv30uk5 222 4 represent represent VBP cord-287815-alv30uk5 222 5 the the DT cord-287815-alv30uk5 222 6 mammalian mammalian JJ cord-287815-alv30uk5 222 7 homologs homolog NNS cord-287815-alv30uk5 222 8 of of IN cord-287815-alv30uk5 222 9 yeast yeast NN cord-287815-alv30uk5 222 10 genes gene NNS cord-287815-alv30uk5 222 11 known know VBN cord-287815-alv30uk5 222 12 to to TO cord-287815-alv30uk5 222 13 be be VB cord-287815-alv30uk5 222 14 involved involve VBN cord-287815-alv30uk5 222 15 in in IN cord-287815-alv30uk5 222 16 intracellular intracellular JJ cord-287815-alv30uk5 222 17 transport transport NN cord-287815-alv30uk5 222 18 in in IN cord-287815-alv30uk5 222 19 intact intact JJ cord-287815-alv30uk5 222 20 cells cell NNS cord-287815-alv30uk5 223 1 ( ( -LRB- cord-287815-alv30uk5 223 2 Wilson Wilson NNP cord-287815-alv30uk5 223 3 et et NNP cord-287815-alv30uk5 223 4 al al NNP cord-287815-alv30uk5 223 5 . . . cord-287815-alv30uk5 224 1 , , , cord-287815-alv30uk5 224 2 1989 1989 CD cord-287815-alv30uk5 224 3 ; ; : cord-287815-alv30uk5 224 4 Clary Clary NNP cord-287815-alv30uk5 224 5 et et NNP cord-287815-alv30uk5 224 6 al al NNP cord-287815-alv30uk5 224 7 . . NNP cord-287815-alv30uk5 224 8 , , , cord-287815-alv30uk5 224 9 1990 1990 CD cord-287815-alv30uk5 224 10 ) ) -RRB- cord-287815-alv30uk5 224 11 . . . cord-287815-alv30uk5 225 1 One one CD cord-287815-alv30uk5 225 2 important important JJ cord-287815-alv30uk5 225 3 factor factor NN cord-287815-alv30uk5 225 4 , , , cord-287815-alv30uk5 225 5 designated designate VBN cord-287815-alv30uk5 225 6 NSF NSF NNP cord-287815-alv30uk5 225 7 ( ( -LRB- cord-287815-alv30uk5 225 8 NEM-.sensitive nem-.sensitive JJ cord-287815-alv30uk5 225 9 fusion fusion NN cord-287815-alv30uk5 225 10 protein protein NN cord-287815-alv30uk5 225 11 ) ) -RRB- cord-287815-alv30uk5 225 12 , , , cord-287815-alv30uk5 225 13 is be VBZ cord-287815-alv30uk5 225 14 homologous homologous JJ cord-287815-alv30uk5 225 15 to to IN cord-287815-alv30uk5 225 16 the the DT cord-287815-alv30uk5 225 17 yeast yeast NN cord-287815-alv30uk5 225 18 sec78 sec78 CD cord-287815-alv30uk5 225 19 gene gene NN cord-287815-alv30uk5 225 20 product product NN cord-287815-alv30uk5 225 21 and and CC cord-287815-alv30uk5 225 22 is be VBZ cord-287815-alv30uk5 225 23 thought think VBN cord-287815-alv30uk5 225 24 to to TO cord-287815-alv30uk5 225 25 act act VB cord-287815-alv30uk5 225 26 at at IN cord-287815-alv30uk5 225 27 a a DT cord-287815-alv30uk5 225 28 late late JJ cord-287815-alv30uk5 225 29 stage stage NN cord-287815-alv30uk5 225 30 in in IN cord-287815-alv30uk5 225 31 transport transport NN cord-287815-alv30uk5 225 32 , , , cord-287815-alv30uk5 225 33 at at IN cord-287815-alv30uk5 225 34 the the DT cord-287815-alv30uk5 225 35 time time NN cord-287815-alv30uk5 225 36 when when WRB cord-287815-alv30uk5 225 37 transport transport NN cord-287815-alv30uk5 225 38 vesicles vesicle NNS cord-287815-alv30uk5 225 39 fuse fuse VBP cord-287815-alv30uk5 225 40 with with IN cord-287815-alv30uk5 225 41 the the DT cord-287815-alv30uk5 225 42 acceptor acceptor NN cord-287815-alv30uk5 225 43 membranes membrane NNS cord-287815-alv30uk5 225 44 Orci Orci NNP cord-287815-alv30uk5 225 45 et et NNP cord-287815-alv30uk5 225 46 al al NNP cord-287815-alv30uk5 225 47 . . NNP cord-287815-alv30uk5 225 48 , , , cord-287815-alv30uk5 225 49 1989 1989 CD cord-287815-alv30uk5 225 50 ; ; : cord-287815-alv30uk5 225 51 Rexach Rexach NNP cord-287815-alv30uk5 225 52 and and CC cord-287815-alv30uk5 225 53 Schekman Schekman NNP cord-287815-alv30uk5 225 54 , , , cord-287815-alv30uk5 225 55 1991 1991 CD cord-287815-alv30uk5 225 56 ) ) -RRB- cord-287815-alv30uk5 225 57 both both CC cord-287815-alv30uk5 225 58 in in IN cord-287815-alv30uk5 225 59 ER ER NNP cord-287815-alv30uk5 225 60 to to IN cord-287815-alv30uk5 225 61 Golgi Golgi NNP cord-287815-alv30uk5 225 62 and and CC cord-287815-alv30uk5 225 63 in in IN cord-287815-alv30uk5 225 64 Golgi Golgi NNP cord-287815-alv30uk5 225 65 as as RB cord-287815-alv30uk5 225 66 well well RB cord-287815-alv30uk5 225 67 as as IN cord-287815-alv30uk5 225 68 in in IN cord-287815-alv30uk5 225 69 post post JJ cord-287815-alv30uk5 225 70 - - JJ cord-287815-alv30uk5 225 71 Golgi golgi JJ cord-287815-alv30uk5 225 72 transport transport NN cord-287815-alv30uk5 225 73 ( ( -LRB- cord-287815-alv30uk5 225 74 Graham Graham NNP cord-287815-alv30uk5 225 75 and and CC cord-287815-alv30uk5 225 76 Emr Emr NNP cord-287815-alv30uk5 225 77 , , , cord-287815-alv30uk5 225 78 1991 1991 CD cord-287815-alv30uk5 225 79 ) ) -RRB- cord-287815-alv30uk5 225 80 . . . cord-287815-alv30uk5 226 1 The the DT cord-287815-alv30uk5 226 2 precise precise JJ cord-287815-alv30uk5 226 3 function function NN cord-287815-alv30uk5 226 4 of of IN cord-287815-alv30uk5 226 5 NSF NSF NNP cord-287815-alv30uk5 226 6 , , , cord-287815-alv30uk5 226 7 however however RB cord-287815-alv30uk5 226 8 , , , cord-287815-alv30uk5 226 9 remains remain VBZ cord-287815-alv30uk5 226 10 unknown unknown JJ cord-287815-alv30uk5 226 11 . . . cord-287815-alv30uk5 227 1 Another another DT cord-287815-alv30uk5 227 2 factor factor NN cord-287815-alv30uk5 227 3 , , , cord-287815-alv30uk5 227 4 designated designate VBN cord-287815-alv30uk5 227 5 SNAP SNAP NNP cord-287815-alv30uk5 227 6 ( ( -LRB- cord-287815-alv30uk5 227 7 for for IN cord-287815-alv30uk5 227 8 soluble soluble JJ cord-287815-alv30uk5 227 9 NSF NSF NNP cord-287815-alv30uk5 227 10 attachment attachment NN cord-287815-alv30uk5 227 11 protein protein NN cord-287815-alv30uk5 227 12 ) ) -RRB- cord-287815-alv30uk5 227 13 , , , cord-287815-alv30uk5 227 14 is be VBZ cord-287815-alv30uk5 227 15 homologous homologous JJ cord-287815-alv30uk5 227 16 to to IN cord-287815-alv30uk5 227 17 the the DT cord-287815-alv30uk5 227 18 yeast yeast NN cord-287815-alv30uk5 227 19 sec77 sec77 NNS cord-287815-alv30uk5 227 20 gene gene NN cord-287815-alv30uk5 227 21 product product NN cord-287815-alv30uk5 227 22 and and CC cord-287815-alv30uk5 227 23 is be VBZ cord-287815-alv30uk5 227 24 thought think VBN cord-287815-alv30uk5 227 25 to to TO cord-287815-alv30uk5 227 26 be be VB cord-287815-alv30uk5 227 27 involved involve VBN cord-287815-alv30uk5 227 28 in in IN cord-287815-alv30uk5 227 29 NSF NSF NNP cord-287815-alv30uk5 227 30 binding bind VBG cord-287815-alv30uk5 227 31 to to IN cord-287815-alv30uk5 227 32 membranes membrane NNS cord-287815-alv30uk5 227 33 ( ( -LRB- cord-287815-alv30uk5 227 34 Clary Clary NNP cord-287815-alv30uk5 227 35 et et NNP cord-287815-alv30uk5 227 36 al al NNP cord-287815-alv30uk5 227 37 . . NNP cord-287815-alv30uk5 227 38 , , , cord-287815-alv30uk5 227 39 1990 1990 CD cord-287815-alv30uk5 227 40 ) ) -RRB- cord-287815-alv30uk5 227 41 . . . cord-287815-alv30uk5 228 1 The the DT cord-287815-alv30uk5 228 2 strongest strong JJS cord-287815-alv30uk5 228 3 evidence evidence NN cord-287815-alv30uk5 228 4 for for IN cord-287815-alv30uk5 228 5 the the DT cord-287815-alv30uk5 228 6 existence existence NN cord-287815-alv30uk5 228 7 of of IN cord-287815-alv30uk5 228 8 a a DT cord-287815-alv30uk5 228 9 vesicular vesicular JJ cord-287815-alv30uk5 228 10 intermediate intermediate NN cord-287815-alv30uk5 228 11 in in IN cord-287815-alv30uk5 228 12 the the DT cord-287815-alv30uk5 228 13 in in FW cord-287815-alv30uk5 228 14 vitro vitro FW cord-287815-alv30uk5 228 15 transport transport NN cord-287815-alv30uk5 228 16 reaction reaction NN cord-287815-alv30uk5 228 17 has have VBZ cord-287815-alv30uk5 228 18 been be VBN cord-287815-alv30uk5 228 19 provided provide VBN cord-287815-alv30uk5 228 20 by by IN cord-287815-alv30uk5 228 21 the the DT cord-287815-alv30uk5 228 22 identification identification NN cord-287815-alv30uk5 228 23 and and CC cord-287815-alv30uk5 228 24 isolation isolation NN cord-287815-alv30uk5 228 25 of of IN cord-287815-alv30uk5 228 26 the the DT cord-287815-alv30uk5 228 27 presumed presume VBN cord-287815-alv30uk5 228 28 carrier carrier NN cord-287815-alv30uk5 228 29 vesicles vesicle VBZ cord-287815-alv30uk5 228 30 themselves -PRON- PRP cord-287815-alv30uk5 228 31 . . . cord-287815-alv30uk5 229 1 During during IN cord-287815-alv30uk5 229 2 the the DT cord-287815-alv30uk5 229 3 early early JJ cord-287815-alv30uk5 229 4 stagesof stagesof NNP cord-287815-alv30uk5 229 5 the the DT cord-287815-alv30uk5 229 6 reaction reaction NN cord-287815-alv30uk5 229 7 , , , cord-287815-alv30uk5 229 8 isolated isolate VBN cord-287815-alv30uk5 229 9 Golgi Golgi NNP cord-287815-alv30uk5 229 10 membranes membrane NNS cord-287815-alv30uk5 229 11 generate generate VBP cord-287815-alv30uk5 229 12 an an DT cord-287815-alv30uk5 229 13 array array NN cord-287815-alv30uk5 229 14 of of IN cord-287815-alv30uk5 229 15 coated coated JJ cord-287815-alv30uk5 229 16 tubules tubule NNS cord-287815-alv30uk5 229 17 , , , cord-287815-alv30uk5 229 18 buds bud NNS cord-287815-alv30uk5 229 19 , , , cord-287815-alv30uk5 229 20 and and CC cord-287815-alv30uk5 229 21 vesicles vesicle NNS cord-287815-alv30uk5 229 22 ( ( -LRB- cord-287815-alv30uk5 229 23 Orci Orci NNP cord-287815-alv30uk5 229 24 et et NNP cord-287815-alv30uk5 229 25 al al NNP cord-287815-alv30uk5 229 26 . . NNP cord-287815-alv30uk5 229 27 , , , cord-287815-alv30uk5 229 28 ' ' '' cord-287815-alv30uk5 229 29 1986 1986 CD cord-287815-alv30uk5 229 30 ) ) -RRB- cord-287815-alv30uk5 229 31 . . . cord-287815-alv30uk5 230 1 The the DT cord-287815-alv30uk5 230 2 vesicles vesicle NNS cord-287815-alv30uk5 230 3 have have VBP cord-287815-alv30uk5 230 4 been be VBN cord-287815-alv30uk5 230 5 isolated isolate VBN cord-287815-alv30uk5 230 6 ( ( -LRB- cord-287815-alv30uk5 230 7 after after IN cord-287815-alv30uk5 230 8 elution elution NN cord-287815-alv30uk5 230 9 from from IN cord-287815-alv30uk5 230 10 l l NN cord-287815-alv30uk5 230 11 : : : cord-287815-alv30uk5 230 12 heir heir NN cord-287815-alv30uk5 230 13 membrane membrane NN cord-287815-alv30uk5 230 14 - - HYPH cord-287815-alv30uk5 230 15 bound bind VBN cord-287815-alv30uk5 230 16 state state NN cord-287815-alv30uk5 230 17 by by IN cord-287815-alv30uk5 230 18 high high JJ cord-287815-alv30uk5 230 19 salt salt NN cord-287815-alv30uk5 230 20 ) ) -RRB- cord-287815-alv30uk5 230 21 , , , cord-287815-alv30uk5 230 22 and and CC cord-287815-alv30uk5 230 23 their -PRON- PRP$ cord-287815-alv30uk5 230 24 coats coat NNS cord-287815-alv30uk5 230 25 have have VBP cord-287815-alv30uk5 230 26 been be VBN cord-287815-alv30uk5 230 27 found find VBN cord-287815-alv30uk5 230 28 to to TO cord-287815-alv30uk5 230 29 contain contain VB cord-287815-alv30uk5 230 30 several several JJ cord-287815-alv30uk5 230 31 unique unique JJ cord-287815-alv30uk5 230 32 components component NNS cord-287815-alv30uk5 230 33 . . . cord-287815-alv30uk5 231 1 One one CD cord-287815-alv30uk5 231 2 of of IN cord-287815-alv30uk5 231 3 these these DT cord-287815-alv30uk5 231 4 , , , cord-287815-alv30uk5 231 5 B b NN cord-287815-alv30uk5 231 6 - - HYPH cord-287815-alv30uk5 231 7 COP cop NN cord-287815-alv30uk5 231 8 , , , cord-287815-alv30uk5 231 9 was be VBD cord-287815-alv30uk5 231 10 previously previously RB cord-287815-alv30uk5 231 11 identified identify VBN cord-287815-alv30uk5 231 12 by by IN cord-287815-alv30uk5 231 13 Kreis Kreis NNP cord-287815-alv30uk5 231 14 and and CC cord-287815-alv30uk5 231 15 coworkers coworker NNS cord-287815-alv30uk5 231 16 as as IN cord-287815-alv30uk5 231 17 a a DT cord-287815-alv30uk5 231 18 110 110 CD cord-287815-alv30uk5 231 19 kd kd NNP cord-287815-alv30uk5 231 20 peripheral peripheral JJ cord-287815-alv30uk5 231 21 protein protein NN cord-287815-alv30uk5 231 22 tightly tightly RB cord-287815-alv30uk5 231 23 associated associate VBN cord-287815-alv30uk5 231 24 with with IN cord-287815-alv30uk5 231 25 the the DT cord-287815-alv30uk5 231 26 Golgi Golgi NNP cord-287815-alv30uk5 231 27 ( ( -LRB- cord-287815-alv30uk5 231 28 Allan Allan NNP cord-287815-alv30uk5 231 29 and and CC cord-287815-alv30uk5 231 30 IKreis IKreis NNP cord-287815-alv30uk5 231 31 , , , cord-287815-alv30uk5 231 32 1986 1986 CD cord-287815-alv30uk5 231 33 ; ; : cord-287815-alv30uk5 231 34 Duden Duden NNP cord-287815-alv30uk5 231 35 et et NNP cord-287815-alv30uk5 231 36 al al NNP cord-287815-alv30uk5 231 37 . . NNP cord-287815-alv30uk5 231 38 , , , cord-287815-alv30uk5 231 39 1991b 1991b CD cord-287815-alv30uk5 231 40 ; ; : cord-287815-alv30uk5 232 1 Serafini Serafini NNP cord-287815-alv30uk5 232 2 et et NNP cord-287815-alv30uk5 232 3 al al NNP cord-287815-alv30uk5 232 4 . . NNP cord-287815-alv30uk5 232 5 , , , cord-287815-alv30uk5 232 6 1991 1991 CD cord-287815-alv30uk5 232 7 ) ) -RRB- cord-287815-alv30uk5 232 8 . . . cord-287815-alv30uk5 233 1 These these DT cord-287815-alv30uk5 233 2 non non JJ cord-287815-alv30uk5 233 3 - - JJ cord-287815-alv30uk5 233 4 clathrin clathrin JJ cord-287815-alv30uk5 233 5 - - HYPH cord-287815-alv30uk5 233 6 coated coat VBN cord-287815-alv30uk5 233 7 vesicles vesicle NNS cord-287815-alv30uk5 233 8 are be VBP cord-287815-alv30uk5 233 9 good good JJ cord-287815-alv30uk5 233 10 candidates candidate NNS cord-287815-alv30uk5 233 11 , , , cord-287815-alv30uk5 233 12 for for IN cord-287815-alv30uk5 233 13 carrier carrier NN cord-287815-alv30uk5 233 14 vesicles vesicle NNS cord-287815-alv30uk5 233 15 . . . cord-287815-alv30uk5 234 1 First first RB cord-287815-alv30uk5 234 2 , , , cord-287815-alv30uk5 234 3 they -PRON- PRP cord-287815-alv30uk5 234 4 contain contain VBP cord-287815-alv30uk5 234 5 VSV VSV NNP cord-287815-alv30uk5 234 6 G G NNP cord-287815-alv30uk5 234 7 protein protein NN cord-287815-alv30uk5 234 8 , , , cord-287815-alv30uk5 234 9 the the DT cord-287815-alv30uk5 234 10 iprotein iprotein NNP cord-287815-alv30uk5 234 11 being be VBG cord-287815-alv30uk5 234 12 transported transport VBN cord-287815-alv30uk5 234 13 ( ( -LRB- cord-287815-alv30uk5 234 14 Orci Orci NNP cord-287815-alv30uk5 234 15 et et NNP cord-287815-alv30uk5 234 16 al al NNP cord-287815-alv30uk5 234 17 . . NNP cord-287815-alv30uk5 234 18 , , , cord-287815-alv30uk5 234 19 1986 1986 CD cord-287815-alv30uk5 235 1 Serafini Serafini NNP cord-287815-alv30uk5 235 2 let let VBD cord-287815-alv30uk5 235 3 al al NNP cord-287815-alv30uk5 235 4 . . NNP cord-287815-alv30uk5 235 5 , , , cord-287815-alv30uk5 235 6 1991 1991 CD cord-287815-alv30uk5 235 7 ) ) -RRB- cord-287815-alv30uk5 235 8 . . . cord-287815-alv30uk5 236 1 Next next RB cord-287815-alv30uk5 236 2 , , , cord-287815-alv30uk5 236 3 conditions condition NNS cord-287815-alv30uk5 236 4 that that WDT cord-287815-alv30uk5 236 5 block block VBP cord-287815-alv30uk5 236 6 the the DT cord-287815-alv30uk5 236 7 transport transport NN cord-287815-alv30uk5 236 8 reac reac NN cord-287815-alv30uk5 236 9 - - HYPH cord-287815-alv30uk5 236 10 tion tion NN cord-287815-alv30uk5 236 11 in in IN cord-287815-alv30uk5 236 12 general general JJ cord-287815-alv30uk5 236 13 result result NN cord-287815-alv30uk5 236 14 in in IN cord-287815-alv30uk5 236 15 the the DT cord-287815-alv30uk5 236 16 accumulation accumulation NN cord-287815-alv30uk5 236 17 or or CC cord-287815-alv30uk5 236 18 lack lack NN cord-287815-alv30uk5 236 19 of of IN cord-287815-alv30uk5 236 20 formation formation NN cord-287815-alv30uk5 236 21 of of IN cord-287815-alv30uk5 236 22 vesicles vesicle NNS cord-287815-alv30uk5 236 23 . . . cord-287815-alv30uk5 237 1 Most most RBS cord-287815-alv30uk5 237 2 interestingly interestingly RB cord-287815-alv30uk5 237 3 , , , cord-287815-alv30uk5 237 4 treatment treatment NN cord-287815-alv30uk5 237 5 of of IN cord-287815-alv30uk5 237 6 cells cell NNS cord-287815-alv30uk5 237 7 or or CC cord-287815-alv30uk5 237 8 isolated isolate VBN cord-287815-alv30uk5 237 9 membranes membrane NNS cord-287815-alv30uk5 237 10 with with IN cord-287815-alv30uk5 237 11 the the DT cord-287815-alv30uk5 237 12 nonhydrolyzable nonhydrolyzable JJ cord-287815-alv30uk5 237 13 GTP GTP NNP cord-287815-alv30uk5 237 14 analog analog NN cord-287815-alv30uk5 237 15 , , , cord-287815-alv30uk5 237 16 GTPyS gtpys CD cord-287815-alv30uk5 237 17 , , , cord-287815-alv30uk5 237 18 both both DT cord-287815-alv30uk5 237 19 blocks block VBZ cord-287815-alv30uk5 237 20 glycosylation glycosylation NN cord-287815-alv30uk5 237 21 of of IN cord-287815-alv30uk5 237 22 the the DT cord-287815-alv30uk5 237 23 VSV VSV NNP cord-287815-alv30uk5 237 24 G G NNP cord-287815-alv30uk5 237 25 protein protein NN cord-287815-alv30uk5 237 26 and and CC cord-287815-alv30uk5 237 27 results result NNS cord-287815-alv30uk5 237 28 in in IN cord-287815-alv30uk5 237 29 the the DT cord-287815-alv30uk5 237 30 accumulation accumulation NN cord-287815-alv30uk5 237 31 of of IN cord-287815-alv30uk5 237 32 VSV VSV NNP cord-287815-alv30uk5 237 33 G G NNP cord-287815-alv30uk5 237 34 protein protein NN cord-287815-alv30uk5 237 35 - - HYPH cord-287815-alv30uk5 237 36 containing contain VBG cord-287815-alv30uk5 237 37 coated coated JJ cord-287815-alv30uk5 237 38 buds bud NNS cord-287815-alv30uk5 237 39 and and CC cord-287815-alv30uk5 237 40 vesicles vesicle NNS cord-287815-alv30uk5 237 41 . . . cord-287815-alv30uk5 238 1 Similar similar JJ cord-287815-alv30uk5 238 2 results result NNS cord-287815-alv30uk5 238 3 were be VBD cord-287815-alv30uk5 238 4 obtained obtain VBN cord-287815-alv30uk5 238 5 using use VBG cord-287815-alv30uk5 238 6 AIF4 AIF4 NNP cord-287815-alv30uk5 238 7 , , , cord-287815-alv30uk5 238 8 an an DT cord-287815-alv30uk5 238 9 inhibitor inhibitor NN cord-287815-alv30uk5 238 10 of of IN cord-287815-alv30uk5 238 11 conventional conventional JJ cord-287815-alv30uk5 238 12 GTP gtp NN cord-287815-alv30uk5 238 13 - - HYPH cord-287815-alv30uk5 238 14 binding bind VBG cord-287815-alv30uk5 238 15 " " `` cord-287815-alv30uk5 238 16 G g NN cord-287815-alv30uk5 238 17 proteins protein NNS cord-287815-alv30uk5 238 18 " " '' cord-287815-alv30uk5 238 19 Kahn Kahn NNP cord-287815-alv30uk5 238 20 , , , cord-287815-alv30uk5 238 21 1991 1991 CD cord-287815-alv30uk5 238 22 ) ) -RRB- cord-287815-alv30uk5 238 23 . . . cord-287815-alv30uk5 239 1 The the DT cord-287815-alv30uk5 239 2 stage stage NN cord-287815-alv30uk5 239 3 at at IN cord-287815-alv30uk5 239 4 which which WDT cord-287815-alv30uk5 239 5 these these DT cord-287815-alv30uk5 239 6 inhibitors inhibitor NNS cord-287815-alv30uk5 239 7 act act NNP cord-287815-alv30uk5 239 8 remains remain VBZ cord-287815-alv30uk5 239 9 unknown unknown JJ cord-287815-alv30uk5 240 1 ( ( -LRB- cord-287815-alv30uk5 240 2 Donaldson Donaldson NNP cord-287815-alv30uk5 240 3 et et NNP cord-287815-alv30uk5 240 4 al al NNP cord-287815-alv30uk5 240 5 . . NNP cord-287815-alv30uk5 240 6 , , , cord-287815-alv30uk5 240 7 1991 1991 CD cord-287815-alv30uk5 240 8 b b NN cord-287815-alv30uk5 240 9 ) ) -RRB- cord-287815-alv30uk5 240 10 . . . cord-287815-alv30uk5 241 1 In in IN cord-287815-alv30uk5 241 2 spite spite NN cord-287815-alv30uk5 241 3 of of IN cord-287815-alv30uk5 241 4 this this DT cord-287815-alv30uk5 241 5 large large JJ cord-287815-alv30uk5 241 6 amount amount NN cord-287815-alv30uk5 241 7 of of IN cord-287815-alv30uk5 241 8 correlative correlative JJ cord-287815-alv30uk5 241 9 evidence evidence NN cord-287815-alv30uk5 241 10 , , , cord-287815-alv30uk5 241 11 additional additional JJ cord-287815-alv30uk5 241 12 data datum NNS cord-287815-alv30uk5 241 13 will will MD cord-287815-alv30uk5 241 14 be be VB cord-287815-alv30uk5 241 15 required require VBN cord-287815-alv30uk5 241 16 before before IN cord-287815-alv30uk5 241 17 it -PRON- PRP cord-287815-alv30uk5 241 18 is be VBZ cord-287815-alv30uk5 241 19 certain certain JJ cord-287815-alv30uk5 241 20 that that IN cord-287815-alv30uk5 241 21 the the DT cord-287815-alv30uk5 241 22 coated coat VBN cord-287815-alv30uk5 241 23 vesicles vesicle NNS cord-287815-alv30uk5 241 24 serve serve VBP cord-287815-alv30uk5 241 25 as as IN cord-287815-alv30uk5 241 26 unique unique JJ cord-287815-alv30uk5 241 27 and and CC cord-287815-alv30uk5 241 28 obligatory obligatory JJ cord-287815-alv30uk5 241 29 transport transport NN cord-287815-alv30uk5 241 30 intermediates intermediate NNS cord-287815-alv30uk5 241 31 either either CC cord-287815-alv30uk5 241 32 in in IN cord-287815-alv30uk5 241 33 vitro vitro FW cord-287815-alv30uk5 241 34 or or CC cord-287815-alv30uk5 241 35 in in IN cord-287815-alv30uk5 241 36 intact intact JJ cord-287815-alv30uk5 241 37 cells cell NNS cord-287815-alv30uk5 241 38 . . . cord-287815-alv30uk5 242 1 Perhaps perhaps RB cord-287815-alv30uk5 242 2 the the DT cord-287815-alv30uk5 242 3 most most RBS cord-287815-alv30uk5 242 4 important important JJ cord-287815-alv30uk5 242 5 piece piece NN cord-287815-alv30uk5 242 6 of of IN cord-287815-alv30uk5 242 7 missing miss VBG cord-287815-alv30uk5 242 8 information information NN cord-287815-alv30uk5 242 9 pertains pertain VBZ cord-287815-alv30uk5 242 10 to to IN cord-287815-alv30uk5 242 11 whether whether IN cord-287815-alv30uk5 242 12 the the DT cord-287815-alv30uk5 242 13 vesicles vesicle NNS cord-287815-alv30uk5 242 14 have have VBP cord-287815-alv30uk5 242 15 a a DT cord-287815-alv30uk5 242 16 composition composition NN cord-287815-alv30uk5 242 17 consistent consistent JJ cord-287815-alv30uk5 242 18 with with IN cord-287815-alv30uk5 242 19 their -PRON- PRP$ cord-287815-alv30uk5 242 20 presumed presume VBN cord-287815-alv30uk5 242 21 transport transport NN cord-287815-alv30uk5 242 22 function function NN cord-287815-alv30uk5 242 23 . . . cord-287815-alv30uk5 243 1 For for IN cord-287815-alv30uk5 243 2 example example NN cord-287815-alv30uk5 243 3 , , , cord-287815-alv30uk5 243 4 it -PRON- PRP cord-287815-alv30uk5 243 5 will will MD cord-287815-alv30uk5 243 6 be be VB cord-287815-alv30uk5 243 7 important important JJ cord-287815-alv30uk5 243 8 to to TO cord-287815-alv30uk5 243 9 confirm confirm VB cord-287815-alv30uk5 243 10 that that IN cord-287815-alv30uk5 243 11 the the DT cord-287815-alv30uk5 243 12 Golgi Golgi NNP cord-287815-alv30uk5 243 13 vesicles vesicle NNS cord-287815-alv30uk5 243 14 do do VBP cord-287815-alv30uk5 243 15 not not RB cord-287815-alv30uk5 243 16 contain contain VB cord-287815-alv30uk5 243 17 resident resident JJ cord-287815-alv30uk5 243 18 proteins protein NNS cord-287815-alv30uk5 243 19 , , , cord-287815-alv30uk5 243 20 e.g. e.g. RB cord-287815-alv30uk5 243 21 , , , cord-287815-alv30uk5 243 22 glycosyltransferases glycosyltransferase NNS cord-287815-alv30uk5 243 23 , , , cord-287815-alv30uk5 243 24 that that WDT cord-287815-alv30uk5 243 25 are be VBP cord-287815-alv30uk5 243 26 not not RB cord-287815-alv30uk5 243 27 intended intend VBN cord-287815-alv30uk5 243 28 for for IN cord-287815-alv30uk5 243 29 transport transport NN cord-287815-alv30uk5 243 30 . . . cord-287815-alv30uk5 244 1 The the DT cord-287815-alv30uk5 244 2 analogous analogous JJ cord-287815-alv30uk5 244 3 point point NN cord-287815-alv30uk5 244 4 is be VBZ cord-287815-alv30uk5 244 5 well well RB cord-287815-alv30uk5 244 6 established establish VBN cord-287815-alv30uk5 244 7 for for IN cord-287815-alv30uk5 244 8 plasma plasma NN cord-287815-alv30uk5 244 9 membrane membrane NN cord-287815-alv30uk5 244 10 clathrin clathrin NN cord-287815-alv30uk5 244 11 - - HYPH cord-287815-alv30uk5 244 12 coated coat VBN cord-287815-alv30uk5 244 13 vesicles vesicle NNS cord-287815-alv30uk5 244 14 . . . cord-287815-alv30uk5 245 1 Many many JJ cord-287815-alv30uk5 245 2 examples example NNS cord-287815-alv30uk5 245 3 are be VBP cord-287815-alv30uk5 245 4 known know VBN cord-287815-alv30uk5 245 5 where where WRB cord-287815-alv30uk5 245 6 proteins protein NNS cord-287815-alv30uk5 245 7 destined destine VBN cord-287815-alv30uk5 245 8 for for IN cord-287815-alv30uk5 245 9 coated coated JJ cord-287815-alv30uk5 245 10 vesicle vesicle NN cord-287815-alv30uk5 245 11 - - HYPH cord-287815-alv30uk5 245 12 mediated mediate VBN cord-287815-alv30uk5 245 13 endocytosis endocytosis NN cord-287815-alv30uk5 245 14 accumulate accumulate VBP cord-287815-alv30uk5 245 15 at at IN cord-287815-alv30uk5 245 16 coated coated JJ cord-287815-alv30uk5 245 17 pits pit NNS cord-287815-alv30uk5 245 18 , , , cord-287815-alv30uk5 245 19 while while IN cord-287815-alv30uk5 245 20 those those DT cord-287815-alv30uk5 245 21 that that WDT cord-287815-alv30uk5 245 22 are be VBP cord-287815-alv30uk5 245 23 not not RB cord-287815-alv30uk5 245 24 efficiently efficiently RB cord-287815-alv30uk5 245 25 internalized internalize VBN cord-287815-alv30uk5 245 26 do do VBP cord-287815-alv30uk5 245 27 not not RB cord-287815-alv30uk5 245 28 enter enter VB cord-287815-alv30uk5 245 29 coated coated JJ cord-287815-alv30uk5 245 30 pits pit NNS cord-287815-alv30uk5 245 31 ( ( -LRB- cord-287815-alv30uk5 245 32 Pearse Pearse NNP cord-287815-alv30uk5 245 33 and and CC cord-287815-alv30uk5 245 34 Robinson Robinson NNP cord-287815-alv30uk5 245 35 , , , cord-287815-alv30uk5 245 36 1990 1990 CD cord-287815-alv30uk5 245 37 ) ) -RRB- cord-287815-alv30uk5 245 38 . . . cord-287815-alv30uk5 246 1 Another another DT cord-287815-alv30uk5 246 2 critical critical JJ cord-287815-alv30uk5 246 3 unknown unknown NN cord-287815-alv30uk5 246 4 is be VBZ cord-287815-alv30uk5 246 5 a a DT cord-287815-alv30uk5 246 6 demonstration demonstration NN cord-287815-alv30uk5 246 7 that that WDT cord-287815-alv30uk5 246 8 the the DT cord-287815-alv30uk5 246 9 Golgi Golgi NNP cord-287815-alv30uk5 246 10 coated coat VBN cord-287815-alv30uk5 246 11 vesicles vesicle NNS cord-287815-alv30uk5 246 12 are be VBP cord-287815-alv30uk5 246 13 functional functional JJ cord-287815-alv30uk5 246 14 in in IN cord-287815-alv30uk5 246 15 vitro vitro FW cord-287815-alv30uk5 246 16 , , , cord-287815-alv30uk5 246 17 i.e. i.e. FW cord-287815-alv30uk5 246 18 , , , cord-287815-alv30uk5 246 19 that that IN cord-287815-alv30uk5 246 20 VSV VSV NNP cord-287815-alv30uk5 246 21 G G NNP cord-287815-alv30uk5 246 22 protein protein NN cord-287815-alv30uk5 246 23 - - HYPH cord-287815-alv30uk5 246 24 containing contain VBG cord-287815-alv30uk5 246 25 vesicle vesicle NN cord-287815-alv30uk5 246 26 fractions fraction NNS cord-287815-alv30uk5 246 27 can can MD cord-287815-alv30uk5 246 28 be be VB cord-287815-alv30uk5 246 29 used use VBN cord-287815-alv30uk5 246 30 to to TO cord-287815-alv30uk5 246 31 reconstitute reconstitute VB cord-287815-alv30uk5 246 32 transport transport NN cord-287815-alv30uk5 246 33 when when WRB cord-287815-alv30uk5 246 34 added add VBN cord-287815-alv30uk5 246 35 to to IN cord-287815-alv30uk5 246 36 acceptor acceptor NN cord-287815-alv30uk5 246 37 Golgi Golgi NNP cord-287815-alv30uk5 246 38 . . . cord-287815-alv30uk5 247 1 The the DT cord-287815-alv30uk5 247 2 analogous analogous JJ cord-287815-alv30uk5 247 3 experiment experiment NN cord-287815-alv30uk5 247 4 has have VBZ cord-287815-alv30uk5 247 5 recently recently RB cord-287815-alv30uk5 247 6 been be VBN cord-287815-alv30uk5 247 7 accomplished accomplish VBN cord-287815-alv30uk5 247 8 for for IN cord-287815-alv30uk5 247 9 a a DT cord-287815-alv30uk5 247 10 less less RBR cord-287815-alv30uk5 247 11 well well RB cord-287815-alv30uk5 247 12 - - HYPH cord-287815-alv30uk5 247 13 characterized characterize VBN cord-287815-alv30uk5 247 14 vesicle vesicle NN cord-287815-alv30uk5 247 15 fraction fraction NN cord-287815-alv30uk5 247 16 that that WDT cord-287815-alv30uk5 247 17 mediates mediate VBZ cord-287815-alv30uk5 247 18 transport transport NN cord-287815-alv30uk5 247 19 from from IN cord-287815-alv30uk5 247 20 the the DT cord-287815-alv30uk5 247 21 ER ER NNP cord-287815-alv30uk5 247 22 to to IN cord-287815-alv30uk5 247 23 the the DT cord-287815-alv30uk5 247 24 Golgi Golgi NNP cord-287815-alv30uk5 247 25 in in IN cord-287815-alv30uk5 247 26 yeast yeast NN cord-287815-alv30uk5 248 1 ( ( -LRB- cord-287815-alv30uk5 248 2 Groesch Groesch NNP cord-287815-alv30uk5 248 3 et et NNP cord-287815-alv30uk5 248 4 al al NNP cord-287815-alv30uk5 248 5 . . NNP cord-287815-alv30uk5 248 6 , , , cord-287815-alv30uk5 248 7 1990 1990 CD cord-287815-alv30uk5 248 8 ; ; : cord-287815-alv30uk5 248 9 Rexach Rexach NNP cord-287815-alv30uk5 248 10 and and CC cord-287815-alv30uk5 248 11 Schekman Schekman NNP cord-287815-alv30uk5 248 12 , , , cord-287815-alv30uk5 248 13 1991 1991 CD cord-287815-alv30uk5 248 14 ) ) -RRB- cord-287815-alv30uk5 248 15 . . . cord-287815-alv30uk5 249 1 Thus thus RB cord-287815-alv30uk5 249 2 , , , cord-287815-alv30uk5 249 3 in in IN cord-287815-alv30uk5 249 4 principle principle NN cord-287815-alv30uk5 249 5 , , , cord-287815-alv30uk5 249 6 this this DT cord-287815-alv30uk5 249 7 approach approach NN cord-287815-alv30uk5 249 8 should should MD cord-287815-alv30uk5 249 9 be be VB cord-287815-alv30uk5 249 10 possible possible JJ cord-287815-alv30uk5 249 11 . . . cord-287815-alv30uk5 250 1 However however RB cord-287815-alv30uk5 250 2 , , , cord-287815-alv30uk5 250 3 with with IN cord-287815-alv30uk5 250 4 all all DT cord-287815-alv30uk5 250 5 such such JJ cord-287815-alv30uk5 250 6 experiments experiment NNS cord-287815-alv30uk5 250 7 , , , cord-287815-alv30uk5 250 8 it -PRON- PRP cord-287815-alv30uk5 250 9 will will MD cord-287815-alv30uk5 250 10 be be VB cord-287815-alv30uk5 250 11 important important JJ cord-287815-alv30uk5 250 12 to to TO cord-287815-alv30uk5 250 13 ensure ensure VB cord-287815-alv30uk5 250 14 that that IN cord-287815-alv30uk5 250 15 the the DT cord-287815-alv30uk5 250 16 coated coated JJ cord-287815-alv30uk5 250 17 vesicle vesicle NN cord-287815-alv30uk5 250 18 fractions fraction NNS cord-287815-alv30uk5 250 19 used use VBN cord-287815-alv30uk5 250 20 are be VBP cord-287815-alv30uk5 250 21 not not RB cord-287815-alv30uk5 250 22 contaminated contaminate VBN cord-287815-alv30uk5 250 23 with with IN cord-287815-alv30uk5 250 24 uncoated uncoated JJ cord-287815-alv30uk5 250 25 , , , cord-287815-alv30uk5 250 26 fusion fusion NN cord-287815-alv30uk5 250 27 - - HYPH cord-287815-alv30uk5 250 28 competent competent JJ cord-287815-alv30uk5 250 29 membranes membrane NNS cord-287815-alv30uk5 250 30 . . . cord-287815-alv30uk5 251 1 BFA BFA NNP cord-287815-alv30uk5 251 2 Blocks Blocks NNP cord-287815-alv30uk5 251 3 Vesicle Vesicle NNP cord-287815-alv30uk5 251 4 Formation Formation NNP cord-287815-alv30uk5 251 5 without without IN cord-287815-alv30uk5 251 6 Blocking Blocking NNP cord-287815-alv30uk5 251 7 Transport Transport NNP cord-287815-alv30uk5 251 8 A a DT cord-287815-alv30uk5 251 9 reason reason NN cord-287815-alv30uk5 251 10 for for IN cord-287815-alv30uk5 251 11 examining examine VBG cord-287815-alv30uk5 251 12 the the DT cord-287815-alv30uk5 251 13 features feature NNS cord-287815-alv30uk5 251 14 of of IN cord-287815-alv30uk5 251 15 the the DT cord-287815-alv30uk5 251 16 Golgi Golgi NNP cord-287815-alv30uk5 251 17 vesicles vesicle NNS cord-287815-alv30uk5 252 1 so so CC cord-287815-alv30uk5 252 2 carefully carefully RB cord-287815-alv30uk5 252 3 is be VBZ cord-287815-alv30uk5 252 4 indicated indicate VBN cord-287815-alv30uk5 252 5 by by IN cord-287815-alv30uk5 252 6 a a DT cord-287815-alv30uk5 252 7 recent recent JJ cord-287815-alv30uk5 252 8 paper paper NN cord-287815-alv30uk5 252 9 that that WDT cord-287815-alv30uk5 252 10 raises raise VBZ cord-287815-alv30uk5 252 11 the the DT cord-287815-alv30uk5 252 12 possibility possibility NN cord-287815-alv30uk5 252 13 that that IN cord-287815-alv30uk5 252 14 , , , cord-287815-alv30uk5 252 15 at at IN cord-287815-alv30uk5 252 16 least least JJS cord-287815-alv30uk5 252 17 under under IN cord-287815-alv30uk5 252 18 certain certain JJ cord-287815-alv30uk5 252 19 conditions condition NNS cord-287815-alv30uk5 252 20 , , , cord-287815-alv30uk5 252 21 these these DT cord-287815-alv30uk5 252 22 vesicles vesicle NNS cord-287815-alv30uk5 252 23 may may MD cord-287815-alv30uk5 252 24 not not RB cord-287815-alv30uk5 252 25 be be VB cord-287815-alv30uk5 252 26 required require VBN cord-287815-alv30uk5 252 27 for for IN cord-287815-alv30uk5 252 28 transport transport NN cord-287815-alv30uk5 252 29 in in IN cord-287815-alv30uk5 252 30 vitro vitro FW cord-287815-alv30uk5 252 31 . . . cord-287815-alv30uk5 253 1 In in IN cord-287815-alv30uk5 253 2 this this DT cord-287815-alv30uk5 253 3 work work NN cord-287815-alv30uk5 253 4 , , , cord-287815-alv30uk5 253 5 the the DT cord-287815-alv30uk5 253 6 effect effect NN cord-287815-alv30uk5 253 7 of of IN cord-287815-alv30uk5 253 8 BFA BFA NNP cord-287815-alv30uk5 253 9 on on IN cord-287815-alv30uk5 253 10 the the DT cord-287815-alv30uk5 253 11 Golgi Golgi NNP cord-287815-alv30uk5 253 12 transport transport NN cord-287815-alv30uk5 253 13 assay assay NN cord-287815-alv30uk5 253 14 was be VBD cord-287815-alv30uk5 253 15 determined determine VBN cord-287815-alv30uk5 253 16 . . . cord-287815-alv30uk5 254 1 BFA BFA NNP cord-287815-alv30uk5 254 2 is be VBZ cord-287815-alv30uk5 254 3 a a DT cord-287815-alv30uk5 254 4 macrocyclic macrocyclic JJ cord-287815-alv30uk5 254 5 fungal fungal NN cord-287815-alv30uk5 254 6 antibiotic antibiotic NN cord-287815-alv30uk5 254 7 that that WDT cord-287815-alv30uk5 254 8 blocks block VBZ cord-287815-alv30uk5 254 9 the the DT cord-287815-alv30uk5 254 10 transport transport NN cord-287815-alv30uk5 254 11 of of IN cord-287815-alv30uk5 254 12 membrane membrane NN cord-287815-alv30uk5 254 13 and and CC cord-287815-alv30uk5 254 14 secretory secretory NN cord-287815-alv30uk5 254 15 proteins protein NNS cord-287815-alv30uk5 254 16 through through IN cord-287815-alv30uk5 254 17 the the DT cord-287815-alv30uk5 254 18 Golgi Golgi NNP cord-287815-alv30uk5 254 19 ( ( -LRB- cord-287815-alv30uk5 254 20 Takatsuki Takatsuki NNP cord-287815-alv30uk5 254 21 and and CC cord-287815-alv30uk5 254 22 Tamura Tamura NNP cord-287815-alv30uk5 254 23 , , , cord-287815-alv30uk5 254 24 1985 1985 CD cord-287815-alv30uk5 254 25 ; ; : cord-287815-alv30uk5 255 1 Misumi Misumi NNP cord-287815-alv30uk5 255 2 et et NNP cord-287815-alv30uk5 255 3 al al NNP cord-287815-alv30uk5 255 4 . . NNP cord-287815-alv30uk5 255 5 , , , cord-287815-alv30uk5 255 6 1986 1986 CD cord-287815-alv30uk5 255 7 ) ) -RRB- cord-287815-alv30uk5 255 8 . . . cord-287815-alv30uk5 256 1 In in IN cord-287815-alv30uk5 256 2 intact intact JJ cord-287815-alv30uk5 256 3 cells cell NNS cord-287815-alv30uk5 256 4 , , , cord-287815-alv30uk5 256 5 the the DT cord-287815-alv30uk5 256 6 drug drug NN cord-287815-alv30uk5 256 7 causes cause VBZ cord-287815-alv30uk5 256 8 a a DT cord-287815-alv30uk5 256 9 dramatic dramatic JJ cord-287815-alv30uk5 256 10 and and CC cord-287815-alv30uk5 256 11 rapid rapid JJ cord-287815-alv30uk5 256 12 retrograde retrograde JJ cord-287815-alv30uk5 256 13 transport transport NN cord-287815-alv30uk5 256 14 of of IN cord-287815-alv30uk5 256 15 Golgi Golgi NNP cord-287815-alv30uk5 256 16 components component NNS cord-287815-alv30uk5 256 17 back back RB cord-287815-alv30uk5 256 18 to to IN cord-287815-alv30uk5 256 19 the the DT cord-287815-alv30uk5 256 20 ER ER NNP cord-287815-alv30uk5 256 21 via via IN cord-287815-alv30uk5 256 22 a a DT cord-287815-alv30uk5 256 23 system system NN cord-287815-alv30uk5 256 24 of of IN cord-287815-alv30uk5 256 25 tubular tubular JJ cord-287815-alv30uk5 256 26 extensions extension NNS cord-287815-alv30uk5 256 27 ( ( -LRB- cord-287815-alv30uk5 256 28 Lippincott- Lippincott- NNP cord-287815-alv30uk5 256 29 Schwartz Schwartz NNP cord-287815-alv30uk5 256 30 et et NNP cord-287815-alv30uk5 256 31 al al NNP cord-287815-alv30uk5 256 32 . . NNP cord-287815-alv30uk5 256 33 , , , cord-287815-alv30uk5 256 34 1990 1990 CD cord-287815-alv30uk5 256 35 ) ) -RRB- cord-287815-alv30uk5 256 36 . . . cord-287815-alv30uk5 257 1 The the DT cord-287815-alv30uk5 257 2 mechanism mechanism NN cord-287815-alv30uk5 257 3 of of IN cord-287815-alv30uk5 257 4 BFA BFA NNP cord-287815-alv30uk5 257 5 action action NN cord-287815-alv30uk5 257 6 is be VBZ cord-287815-alv30uk5 257 7 unknown unknown JJ cord-287815-alv30uk5 257 8 , , , cord-287815-alv30uk5 257 9 but but CC cord-287815-alv30uk5 257 10 one one CD cord-287815-alv30uk5 257 11 intriguing intriguing JJ cord-287815-alv30uk5 257 12 property property NN cord-287815-alv30uk5 257 13 is be VBZ cord-287815-alv30uk5 257 14 its -PRON- PRP$ cord-287815-alv30uk5 257 15 ability ability NN cord-287815-alv30uk5 257 16 to to TO cord-287815-alv30uk5 257 17 rapidly rapidly RB cord-287815-alv30uk5 257 18 , , , cord-287815-alv30uk5 257 19 and and CC cord-287815-alv30uk5 257 20 reversibly reversibly RB cord-287815-alv30uk5 257 21 , , , cord-287815-alv30uk5 257 22 trigger trigger VB cord-287815-alv30uk5 257 23 the the DT cord-287815-alv30uk5 257 24 dissociation dissociation NN cord-287815-alv30uk5 257 25 of of IN cord-287815-alv30uk5 257 26 B b NN cord-287815-alv30uk5 257 27 - - HYPH cord-287815-alv30uk5 257 28 COP cop NN cord-287815-alv30uk5 258 1 ( ( -LRB- cord-287815-alv30uk5 258 2 Donaldson Donaldson NNP cord-287815-alv30uk5 258 3 et et NNP cord-287815-alv30uk5 258 4 al al NNP cord-287815-alv30uk5 258 5 . . . cord-287815-alv30uk5 259 1 , , , cord-287815-alv30uk5 259 2 1991a 1991a CD cord-287815-alv30uk5 259 3 ; ; : cord-287815-alv30uk5 259 4 Klausner Klausner NNP cord-287815-alv30uk5 259 5 et et NNP cord-287815-alv30uk5 259 6 al al NNP cord-287815-alv30uk5 259 7 . . NNP cord-287815-alv30uk5 259 8 , , , cord-287815-alv30uk5 259 9 1992 1992 CD cord-287815-alv30uk5 259 10 ) ) -RRB- cord-287815-alv30uk5 259 11 . . . cord-287815-alv30uk5 260 1 When when WRB cord-287815-alv30uk5 260 2 isolated isolate VBN cord-287815-alv30uk5 260 3 Golgi Golgi NNP cord-287815-alv30uk5 260 4 was be VBD cord-287815-alv30uk5 260 5 treated treat VBN cord-287815-alv30uk5 260 6 with with IN cord-287815-alv30uk5 260 7 BFA BFA NNP cord-287815-alv30uk5 260 8 , , , cord-287815-alv30uk5 260 9 P p NN cord-287815-alv30uk5 260 10 - - HYPH cord-287815-alv30uk5 260 11 COP cop NN cord-287815-alv30uk5 260 12 was be VBD cord-287815-alv30uk5 260 13 no no RB cord-287815-alv30uk5 260 14 longer long RBR cord-287815-alv30uk5 260 15 associated associate VBN cord-287815-alv30uk5 260 16 with with IN cord-287815-alv30uk5 260 17 the the DT cord-287815-alv30uk5 260 18 membranes membrane NNS cord-287815-alv30uk5 260 19 nor nor CC cord-287815-alv30uk5 260 20 were be VBD cord-287815-alv30uk5 260 21 any any DT cord-287815-alv30uk5 260 22 coated coated JJ cord-287815-alv30uk5 260 23 buds bud NNS cord-287815-alv30uk5 260 24 or or CC cord-287815-alv30uk5 260 25 vesicles vesicle NNS cord-287815-alv30uk5 260 26 detected detect VBN cord-287815-alv30uk5 260 27 . . . cord-287815-alv30uk5 261 1 Nevertheless nevertheless RB cord-287815-alv30uk5 261 2 , , , cord-287815-alv30uk5 261 3 the the DT cord-287815-alv30uk5 261 4 transfer transfer NN cord-287815-alv30uk5 261 5 of of IN cord-287815-alv30uk5 261 6 VSV VSV NNP cord-287815-alv30uk5 261 7 G G NNP cord-287815-alv30uk5 261 8 protein protein NN cord-287815-alv30uk5 261 9 from from IN cord-287815-alv30uk5 261 10 donor donor NN cord-287815-alv30uk5 261 11 to to IN cord-287815-alv30uk5 261 12 acceptor acceptor NN cord-287815-alv30uk5 261 13 Golgi Golgi NNP cord-287815-alv30uk5 261 14 continued continue VBN cord-287815-alv30uk5 261 15 with with IN cord-287815-alv30uk5 261 16 similar similar JJ cord-287815-alv30uk5 261 17 kinetics kinetic NNS cord-287815-alv30uk5 261 18 and and CC cord-287815-alv30uk5 261 19 efficiency efficiency NN cord-287815-alv30uk5 261 20 as as IN cord-287815-alv30uk5 261 21 in in IN cord-287815-alv30uk5 261 22 untreated untreated JJ cord-287815-alv30uk5 261 23 controls control NNS cord-287815-alv30uk5 261 24 . . . cord-287815-alv30uk5 262 1 The the DT cord-287815-alv30uk5 262 2 only only JJ cord-287815-alv30uk5 262 3 difference difference NN cord-287815-alv30uk5 262 4 was be VBD cord-287815-alv30uk5 262 5 that that DT cord-287815-alv30uk5 262 6 transfer transfer NN cord-287815-alv30uk5 262 7 in in IN cord-287815-alv30uk5 262 8 BFA BFA NNP cord-287815-alv30uk5 262 9 - - HYPH cord-287815-alv30uk5 262 10 treated treat VBN cord-287815-alv30uk5 262 11 Golgi Golgi NNP cord-287815-alv30uk5 262 12 lost lose VBD cord-287815-alv30uk5 262 13 its -PRON- PRP$ cord-287815-alv30uk5 262 14 sensitivity sensitivity NN cord-287815-alv30uk5 262 15 to to IN cord-287815-alv30uk5 262 16 GTPyS gtpys NN cord-287815-alv30uk5 262 17 inhibition inhibition NN cord-287815-alv30uk5 262 18 . . . cord-287815-alv30uk5 263 1 There there EX cord-287815-alv30uk5 263 2 are be VBP cord-287815-alv30uk5 263 3 two two CD cord-287815-alv30uk5 263 4 possible possible JJ cord-287815-alv30uk5 263 5 interpretations interpretation NNS cord-287815-alv30uk5 263 6 of of IN cord-287815-alv30uk5 263 7 these these DT cord-287815-alv30uk5 263 8 results result NNS cord-287815-alv30uk5 263 9 . . . cord-287815-alv30uk5 264 1 The the DT cord-287815-alv30uk5 264 2 first first JJ cord-287815-alv30uk5 264 3 is be VBZ cord-287815-alv30uk5 264 4 that that IN cord-287815-alv30uk5 264 5 coated coat VBN cord-287815-alv30uk5 264 6 vesicles vesicle NNS cord-287815-alv30uk5 264 7 that that WDT cord-287815-alv30uk5 264 8 form form VBP cord-287815-alv30uk5 264 9 in in IN cord-287815-alv30uk5 264 10 the the DT cord-287815-alv30uk5 264 11 assay assay NN cord-287815-alv30uk5 264 12 system system NN cord-287815-alv30uk5 264 13 are be VBP cord-287815-alv30uk5 264 14 not not RB cord-287815-alv30uk5 264 15 obligatory obligatory JJ cord-287815-alv30uk5 264 16 intermediates intermediate NNS cord-287815-alv30uk5 264 17 in in IN cord-287815-alv30uk5 264 18 the the DT cord-287815-alv30uk5 264 19 transport transport NN cord-287815-alv30uk5 264 20 event event NN cord-287815-alv30uk5 264 21 , , , cord-287815-alv30uk5 264 22 even even RB cord-287815-alv30uk5 264 23 in in IN cord-287815-alv30uk5 264 24 the the DT cord-287815-alv30uk5 264 25 absence absence NN cord-287815-alv30uk5 264 26 of of IN cord-287815-alv30uk5 264 27 the the DT cord-287815-alv30uk5 264 28 drug drug NN cord-287815-alv30uk5 264 29 . . . cord-287815-alv30uk5 265 1 Alternatively alternatively RB cord-287815-alv30uk5 265 2 , , , cord-287815-alv30uk5 265 3 BFA BFA NNP cord-287815-alv30uk5 265 4 may may MD cord-287815-alv30uk5 265 5 induce induce VB cord-287815-alv30uk5 265 6 an an DT cord-287815-alv30uk5 265 7 aberrant aberrant JJ cord-287815-alv30uk5 265 8 form form NN cord-287815-alv30uk5 265 9 of of IN cord-287815-alv30uk5 265 10 transport transport NN cord-287815-alv30uk5 265 11 that that WDT cord-287815-alv30uk5 265 12 nevertheless nevertheless RB cord-287815-alv30uk5 265 13 utilizes utilize VBZ cord-287815-alv30uk5 265 14 enzymatic enzymatic JJ cord-287815-alv30uk5 265 15 machinery machinery NN cord-287815-alv30uk5 265 16 required require VBN cord-287815-alv30uk5 265 17 for for IN cord-287815-alv30uk5 265 18 vesicular vesicular JJ cord-287815-alv30uk5 265 19 transport transport NN cord-287815-alv30uk5 265 20 in in IN cord-287815-alv30uk5 265 21 the the DT cord-287815-alv30uk5 265 22 absence absence NN cord-287815-alv30uk5 265 23 of of IN cord-287815-alv30uk5 265 24 the the DT cord-287815-alv30uk5 265 25 drug drug NN cord-287815-alv30uk5 265 26 . . . cord-287815-alv30uk5 266 1 It -PRON- PRP cord-287815-alv30uk5 266 2 is be VBZ cord-287815-alv30uk5 266 3 at at IN cord-287815-alv30uk5 266 4 present present JJ cord-287815-alv30uk5 266 5 impossible impossible JJ cord-287815-alv30uk5 266 6 to to TO cord-287815-alv30uk5 266 7 distinguish distinguish VB cord-287815-alv30uk5 266 8 between between IN cord-287815-alv30uk5 266 9 these these DT cord-287815-alv30uk5 266 10 two two CD cord-287815-alv30uk5 266 11 possibilities possibility NNS cord-287815-alv30uk5 266 12 . . . cord-287815-alv30uk5 267 1 However however RB cord-287815-alv30uk5 267 2 , , , cord-287815-alv30uk5 267 3 BFA BFA NNP cord-287815-alv30uk5 267 4 - - HYPH cord-287815-alv30uk5 267 5 treated treat VBN cord-287815-alv30uk5 267 6 Golgi Golgi NNP cord-287815-alv30uk5 267 7 in in IN cord-287815-alv30uk5 267 8 vitro vitro FW cord-287815-alv30uk5 267 9 appear appear VBP cord-287815-alv30uk5 267 10 to to TO cord-287815-alv30uk5 267 11 form form VB cord-287815-alv30uk5 267 12 tubular tubular JJ cord-287815-alv30uk5 267 13 extensions extension NNS cord-287815-alv30uk5 267 14 that that WDT cord-287815-alv30uk5 267 15 may may MD cord-287815-alv30uk5 267 16 serve serve VB cord-287815-alv30uk5 267 17 to to TO cord-287815-alv30uk5 267 18 interconnect interconnect VB cord-287815-alv30uk5 267 19 donor donor NN cord-287815-alv30uk5 267 20 and and CC cord-287815-alv30uk5 267 21 acceptor acceptor NN cord-287815-alv30uk5 267 22 Golgi Golgi NNP cord-287815-alv30uk5 267 23 stacks stack NNS cord-287815-alv30uk5 267 24 , , , cord-287815-alv30uk5 267 25 thus thus RB cord-287815-alv30uk5 267 26 resulting result VBG cord-287815-alv30uk5 267 27 in in IN cord-287815-alv30uk5 267 28 transfer transfer NN cord-287815-alv30uk5 267 29 to to IN cord-287815-alv30uk5 267 30 the the DT cord-287815-alv30uk5 267 31 acceptor acceptor NN cord-287815-alv30uk5 267 32 across across IN cord-287815-alv30uk5 267 33 these these DT cord-287815-alv30uk5 267 34 tubular tubular JJ cord-287815-alv30uk5 267 35 bridges bridge NNS cord-287815-alv30uk5 267 36 . . . cord-287815-alv30uk5 268 1 This this DT cord-287815-alv30uk5 268 2 possibility possibility NN cord-287815-alv30uk5 268 3 is be VBZ cord-287815-alv30uk5 268 4 appealing appeal VBG cord-287815-alv30uk5 268 5 since since IN cord-287815-alv30uk5 268 6 it -PRON- PRP cord-287815-alv30uk5 268 7 could could MD cord-287815-alv30uk5 268 8 reflect reflect VB cord-287815-alv30uk5 268 9 the the DT cord-287815-alv30uk5 268 10 BFA BFA NNP cord-287815-alv30uk5 268 11 - - HYPH cord-287815-alv30uk5 268 12 induced induce VBN cord-287815-alv30uk5 268 13 tubulation tubulation NN cord-287815-alv30uk5 268 14 of of IN cord-287815-alv30uk5 268 15 the the DT cord-287815-alv30uk5 268 16 Golgi Golgi NNP cord-287815-alv30uk5 268 17 seen see VBN cord-287815-alv30uk5 268 18 in in IN cord-287815-alv30uk5 268 19 intact intact JJ cord-287815-alv30uk5 268 20 cells cell NNS cord-287815-alv30uk5 268 21 . . . cord-287815-alv30uk5 269 1 However however RB cord-287815-alv30uk5 269 2 , , , cord-287815-alv30uk5 269 3 additional additional JJ cord-287815-alv30uk5 269 4 electron electron NN cord-287815-alv30uk5 269 5 microscope microscope NN cord-287815-alv30uk5 269 6 immunocytochemistry immunocytochemistry NN cord-287815-alv30uk5 269 7 will will MD cord-287815-alv30uk5 269 8 be be VB cord-287815-alv30uk5 269 9 required require VBN cord-287815-alv30uk5 269 10 to to TO cord-287815-alv30uk5 269 11 establish establish VB cord-287815-alv30uk5 269 12 continuous continuous JJ cord-287815-alv30uk5 269 13 interconnections interconnection NNS cord-287815-alv30uk5 269 14 between between IN cord-287815-alv30uk5 269 15 antigenically antigenically RB cord-287815-alv30uk5 269 16 distinct distinct JJ cord-287815-alv30uk5 269 17 Golgi Golgi NNP cord-287815-alv30uk5 269 18 elements element NNS cord-287815-alv30uk5 269 19 . . . cord-287815-alv30uk5 270 1 Vesicular Vesicular NNP cord-287815-alv30uk5 270 2 Transport Transport NNP cord-287815-alv30uk5 270 3 or or CC cord-287815-alv30uk5 270 4 Golgi Golgi NNP cord-287815-alv30uk5 270 5 Fusion Fusion NNP cord-287815-alv30uk5 270 6 ? ? . cord-287815-alv30uk5 271 1 The the DT cord-287815-alv30uk5 271 2 fact fact NN cord-287815-alv30uk5 271 3 that that IN cord-287815-alv30uk5 271 4 " " `` cord-287815-alv30uk5 271 5 transport transport NN cord-287815-alv30uk5 271 6 " " '' cord-287815-alv30uk5 271 7 ( ( -LRB- cord-287815-alv30uk5 271 8 i.e. i.e. FW cord-287815-alv30uk5 271 9 , , , cord-287815-alv30uk5 271 10 G g NN cord-287815-alv30uk5 271 11 protein protein NN cord-287815-alv30uk5 271 12 glycosylation glycosylation NN cord-287815-alv30uk5 271 13 ) ) -RRB- cord-287815-alv30uk5 271 14 can can MD cord-287815-alv30uk5 271 15 occur occur VB cord-287815-alv30uk5 271 16 in in IN cord-287815-alv30uk5 271 17 the the DT cord-287815-alv30uk5 271 18 absence absence NN cord-287815-alv30uk5 271 19 of of IN cord-287815-alv30uk5 271 20 vesicle vesicle NN cord-287815-alv30uk5 271 21 formation formation NN cord-287815-alv30uk5 271 22 raises raise VBZ cord-287815-alv30uk5 271 23 a a DT cord-287815-alv30uk5 271 24 number number NN cord-287815-alv30uk5 271 25 of of IN cord-287815-alv30uk5 271 26 important important JJ cord-287815-alv30uk5 271 27 questions question NNS cord-287815-alv30uk5 271 28 : : : cord-287815-alv30uk5 271 29 What what WDT cord-287815-alv30uk5 271 30 transport transport NN cord-287815-alv30uk5 271 31 step(s step(s NNP cord-287815-alv30uk5 271 32 ) ) -RRB- cord-287815-alv30uk5 271 33 is be VBZ cord-287815-alv30uk5 271 34 actually actually RB cord-287815-alv30uk5 271 35 being be VBG cord-287815-alv30uk5 271 36 measured measure VBN cord-287815-alv30uk5 271 37 in in IN cord-287815-alv30uk5 271 38 vitro vitro FW cord-287815-alv30uk5 271 39 ? ? . cord-287815-alv30uk5 272 1 What what WP cord-287815-alv30uk5 272 2 is be VBZ cord-287815-alv30uk5 272 3 the the DT cord-287815-alv30uk5 272 4 relationship relationship NN cord-287815-alv30uk5 272 5 of of IN cord-287815-alv30uk5 272 6 the the DT cord-287815-alv30uk5 272 7 events event NNS cord-287815-alv30uk5 272 8 reconstituted reconstitute VBN cord-287815-alv30uk5 272 9 in in IN cord-287815-alv30uk5 272 10 vitro vitro FW cord-287815-alv30uk5 272 11 to to IN cord-287815-alv30uk5 272 12 those those DT cord-287815-alv30uk5 272 13 found find VBN cord-287815-alv30uk5 272 14 in in IN cord-287815-alv30uk5 272 15 intact intact JJ cord-287815-alv30uk5 272 16 cells cell NNS cord-287815-alv30uk5 272 17 ? ? . cord-287815-alv30uk5 273 1 Is be VBZ cord-287815-alv30uk5 273 2 transport transport NN cord-287815-alv30uk5 273 3 in in IN cord-287815-alv30uk5 273 4 vitro vitro FW cord-287815-alv30uk5 273 5 ever ever RB cord-287815-alv30uk5 273 6 completely completely RB cord-287815-alv30uk5 273 7 dependent dependent JJ cord-287815-alv30uk5 273 8 on on IN cord-287815-alv30uk5 273 9 vesicle vesicle NN cord-287815-alv30uk5 273 10 formation formation NN cord-287815-alv30uk5 273 11 , , , cord-287815-alv30uk5 273 12 even even RB cord-287815-alv30uk5 273 13 in in IN cord-287815-alv30uk5 273 14 the the DT cord-287815-alv30uk5 273 15 absence absence NN cord-287815-alv30uk5 273 16 of of IN cord-287815-alv30uk5 273 17 BFA BFA NNP cord-287815-alv30uk5 273 18 ? ? . cord-287815-alv30uk5 274 1 If if IN cord-287815-alv30uk5 274 2 vesicles vesicle NNS cord-287815-alv30uk5 274 3 are be VBP cord-287815-alv30uk5 274 4 not not RB cord-287815-alv30uk5 274 5 involved involve VBN cord-287815-alv30uk5 274 6 , , , cord-287815-alv30uk5 274 7 is be VBZ cord-287815-alv30uk5 274 8 transfer transfer NN cord-287815-alv30uk5 274 9 from from IN cord-287815-alv30uk5 274 10 donor donor NN cord-287815-alv30uk5 274 11 to to IN cord-287815-alv30uk5 274 12 acceptor acceptor NN cord-287815-alv30uk5 274 13 Golgi Golgi NNP cord-287815-alv30uk5 274 14 mediated mediate VBN cord-287815-alv30uk5 274 15 by by IN cord-287815-alv30uk5 274 16 direct direct JJ cord-287815-alv30uk5 274 17 fusion fusion NN cord-287815-alv30uk5 274 18 , , , cord-287815-alv30uk5 274 19 perhaps perhaps RB cord-287815-alv30uk5 274 20 via via IN cord-287815-alv30uk5 274 21 tubular tubular JJ cord-287815-alv30uk5 274 22 extensions extension NNS cord-287815-alv30uk5 274 23 ? ? . cord-287815-alv30uk5 275 1 As as IN cord-287815-alv30uk5 275 2 mentioned mention VBN cord-287815-alv30uk5 275 3 above above RB cord-287815-alv30uk5 275 4 , , , cord-287815-alv30uk5 275 5 it -PRON- PRP cord-287815-alv30uk5 275 6 is be VBZ cord-287815-alv30uk5 275 7 unclear unclear JJ cord-287815-alv30uk5 275 8 whether whether IN cord-287815-alv30uk5 275 9 the the DT cord-287815-alv30uk5 275 10 G g NN cord-287815-alv30uk5 275 11 protein protein NN cord-287815-alv30uk5 275 12 is be VBZ cord-287815-alv30uk5 275 13 transferred transfer VBN cord-287815-alv30uk5 275 14 across across IN cord-287815-alv30uk5 275 15 a a DT cord-287815-alv30uk5 275 16 predicted predict VBN cord-287815-alv30uk5 275 17 compartment compartment NN cord-287815-alv30uk5 275 18 boundary boundary NN cord-287815-alv30uk5 275 19 ( ( -LRB- cord-287815-alv30uk5 275 20 donor donor NN cord-287815-alv30uk5 275 21 CGN CGN NNP cord-287815-alv30uk5 275 22 to to TO cord-287815-alv30uk5 275 23 acceptor acceptor NN cord-287815-alv30uk5 275 24 medial medial NN cord-287815-alv30uk5 275 25 ) ) -RRB- cord-287815-alv30uk5 275 26 or or CC cord-287815-alv30uk5 275 27 within within IN cord-287815-alv30uk5 275 28 a a DT cord-287815-alv30uk5 275 29 single single JJ cord-287815-alv30uk5 275 30 compartment compartment NN cord-287815-alv30uk5 275 31 ( ( -LRB- cord-287815-alv30uk5 275 32 donor donor NN cord-287815-alv30uk5 275 33 medial medial NN cord-287815-alv30uk5 275 34 to to IN cord-287815-alv30uk5 275 35 acceptor acceptor NN cord-287815-alv30uk5 275 36 medial medial NN cord-287815-alv30uk5 275 37 ) ) -RRB- cord-287815-alv30uk5 275 38 . . . cord-287815-alv30uk5 276 1 It -PRON- PRP cord-287815-alv30uk5 276 2 is be VBZ cord-287815-alv30uk5 276 3 becoming become VBG cord-287815-alv30uk5 276 4 increasingly increasingly RB cord-287815-alv30uk5 276 5 clear clear JJ cord-287815-alv30uk5 276 6 that that IN cord-287815-alv30uk5 276 7 all all DT cord-287815-alv30uk5 276 8 membranebound membranebound JJ cord-287815-alv30uk5 276 9 organelles organelle NNS cord-287815-alv30uk5 276 10 have have VBP cord-287815-alv30uk5 276 11 a a DT cord-287815-alv30uk5 276 12 propensity propensity NN cord-287815-alv30uk5 276 13 to to TO cord-287815-alv30uk5 276 14 form form VB cord-287815-alv30uk5 276 15 tubules tubule NNS cord-287815-alv30uk5 276 16 in in IN cord-287815-alv30uk5 276 17 intact intact JJ cord-287815-alv30uk5 276 18 cells cell NNS cord-287815-alv30uk5 276 19 and and CC cord-287815-alv30uk5 276 20 in in IN cord-287815-alv30uk5 276 21 vitro vitro FW cord-287815-alv30uk5 276 22 , , , cord-287815-alv30uk5 276 23 with with IN cord-287815-alv30uk5 276 24 or or CC cord-287815-alv30uk5 276 25 without without IN cord-287815-alv30uk5 276 26 BFA BFA NNP cord-287815-alv30uk5 276 27 treatment treatment NN cord-287815-alv30uk5 276 28 . . . cord-287815-alv30uk5 277 1 For for IN cord-287815-alv30uk5 277 2 example example NN cord-287815-alv30uk5 277 3 , , , cord-287815-alv30uk5 277 4 the the DT cord-287815-alv30uk5 277 5 ER ER NNP cord-287815-alv30uk5 277 6 ( ( -LRB- cord-287815-alv30uk5 277 7 Lee Lee NNP cord-287815-alv30uk5 277 8 and and CC cord-287815-alv30uk5 277 9 Chen Chen NNP cord-287815-alv30uk5 277 10 , , , cord-287815-alv30uk5 277 11 1988 1988 CD cord-287815-alv30uk5 277 12 ) ) -RRB- cord-287815-alv30uk5 277 13 , , , cord-287815-alv30uk5 277 14 mitochondria mitochondrion NNS cord-287815-alv30uk5 277 15 ( ( -LRB- cord-287815-alv30uk5 277 16 Johnson Johnson NNP cord-287815-alv30uk5 277 17 et et NNP cord-287815-alv30uk5 277 18 al al NNP cord-287815-alv30uk5 277 19 . . NNP cord-287815-alv30uk5 277 20 , , , cord-287815-alv30uk5 277 21 1980 1980 CD cord-287815-alv30uk5 277 22 ) ) -RRB- cord-287815-alv30uk5 277 23 peroxisomes peroxisome NNS cord-287815-alv30uk5 277 24 ( ( -LRB- cord-287815-alv30uk5 277 25 Yamamoto Yamamoto NNP cord-287815-alv30uk5 277 26 and and CC cord-287815-alv30uk5 277 27 Fahimi Fahimi NNP cord-287815-alv30uk5 277 28 , , , cord-287815-alv30uk5 277 29 1987 1987 CD cord-287815-alv30uk5 277 30 ) ) -RRB- cord-287815-alv30uk5 277 31 endosomes endosome NNS cord-287815-alv30uk5 277 32 ( ( -LRB- cord-287815-alv30uk5 277 33 Hopkins Hopkins NNP cord-287815-alv30uk5 277 34 et et NNP cord-287815-alv30uk5 277 35 al al NNP cord-287815-alv30uk5 277 36 . . NNP cord-287815-alv30uk5 277 37 , , , cord-287815-alv30uk5 277 38 1990 1990 CD cord-287815-alv30uk5 277 39 ; ; : cord-287815-alv30uk5 277 40 Tooze Tooze NNP cord-287815-alv30uk5 277 41 and and CC cord-287815-alv30uk5 277 42 Hollinshead Hollinshead NNP cord-287815-alv30uk5 277 43 , , , cord-287815-alv30uk5 277 44 1991 1991 CD cord-287815-alv30uk5 277 45 ; ; : cord-287815-alv30uk5 277 46 Hunziker Hunziker NNP cord-287815-alv30uk5 277 47 et et NNP cord-287815-alv30uk5 277 48 al al NNP cord-287815-alv30uk5 277 49 . . NNP cord-287815-alv30uk5 277 50 , , , cord-287815-alv30uk5 277 51 1991b 1991b CD cord-287815-alv30uk5 277 52 ; ; : cord-287815-alv30uk5 277 53 Lippincott Lippincott NNP cord-287815-alv30uk5 277 54 - - HYPH cord-287815-alv30uk5 277 55 Schwartz Schwartz NNP cord-287815-alv30uk5 277 56 et et NNP cord-287815-alv30uk5 277 57 al al NNP cord-287815-alv30uk5 277 58 . . NNP cord-287815-alv30uk5 277 59 , , , cord-287815-alv30uk5 277 60 1991 1991 CD cord-287815-alv30uk5 277 61 ) ) -RRB- cord-287815-alv30uk5 277 62 , , , cord-287815-alv30uk5 277 63 and and CC cord-287815-alv30uk5 277 64 lysosomes lysosome NNS cord-287815-alv30uk5 277 65 ( ( -LRB- cord-287815-alv30uk5 277 66 Swanson Swanson NNP cord-287815-alv30uk5 277 67 et et NNP cord-287815-alv30uk5 277 68 al al NNP cord-287815-alv30uk5 277 69 . . NNP cord-287815-alv30uk5 277 70 , , , cord-287815-alv30uk5 277 71 1987 1987 CD cord-287815-alv30uk5 277 72 ; ; : cord-287815-alv30uk5 277 73 Lippincott Lippincott NNP cord-287815-alv30uk5 277 74 - - HYPH cord-287815-alv30uk5 277 75 Schwartz Schwartz NNP cord-287815-alv30uk5 277 76 et et NNP cord-287815-alv30uk5 277 77 al al NNP cord-287815-alv30uk5 277 78 . . NNP cord-287815-alv30uk5 277 79 , , , cord-287815-alv30uk5 277 80 1991 1991 CD cord-287815-alv30uk5 277 81 ) ) -RRB- cord-287815-alv30uk5 277 82 are be VBP cord-287815-alv30uk5 277 83 all all DT cord-287815-alv30uk5 277 84 capable capable JJ cord-287815-alv30uk5 277 85 of of IN cord-287815-alv30uk5 277 86 forming form VBG cord-287815-alv30uk5 277 87 dynamic dynamic JJ cord-287815-alv30uk5 277 88 tubular tubular JJ cord-287815-alv30uk5 277 89 membrane membrane NN cord-287815-alv30uk5 277 90 networks network NNS cord-287815-alv30uk5 277 91 . . . cord-287815-alv30uk5 278 1 One one CD cord-287815-alv30uk5 278 2 wellstudied wellstudied JJ cord-287815-alv30uk5 278 3 example example NN cord-287815-alv30uk5 278 4 is be VBZ cord-287815-alv30uk5 278 5 the the DT cord-287815-alv30uk5 278 6 early early JJ cord-287815-alv30uk5 278 7 endosome endosome NN cord-287815-alv30uk5 278 8 , , , cord-287815-alv30uk5 278 9 the the DT cord-287815-alv30uk5 278 10 structure structure NN cord-287815-alv30uk5 278 11 of of IN cord-287815-alv30uk5 278 12 which which WDT cord-287815-alv30uk5 278 13 varies vary VBZ cord-287815-alv30uk5 278 14 in in IN cord-287815-alv30uk5 278 15 different different JJ cord-287815-alv30uk5 278 16 cell cell NN cord-287815-alv30uk5 278 17 types type NNS cord-287815-alv30uk5 278 18 ( ( -LRB- cord-287815-alv30uk5 278 19 Marsh Marsh NNP cord-287815-alv30uk5 278 20 et et NNP cord-287815-alv30uk5 278 21 al al NNP cord-287815-alv30uk5 278 22 . . NNP cord-287815-alv30uk5 278 23 , , , cord-287815-alv30uk5 278 24 1986 1986 CD cord-287815-alv30uk5 278 25 ; ; . cord-287815-alv30uk5 279 1 Tooze Tooze NNP cord-287815-alv30uk5 279 2 et et NNP cord-287815-alv30uk5 279 3 al al NNP cord-287815-alv30uk5 279 4 . . NNP cord-287815-alv30uk5 279 5 , , , cord-287815-alv30uk5 279 6 1991 1991 CD cord-287815-alv30uk5 279 7 ) ) -RRB- cord-287815-alv30uk5 279 8 . . . cord-287815-alv30uk5 280 1 Cell cell NN cord-287815-alv30uk5 280 2 - - HYPH cord-287815-alv30uk5 280 3 free free JJ cord-287815-alv30uk5 280 4 assays assay NNS cord-287815-alv30uk5 280 5 have have VBP cord-287815-alv30uk5 280 6 documented document VBN cord-287815-alv30uk5 280 7 that that IN cord-287815-alv30uk5 280 8 the the DT cord-287815-alv30uk5 280 9 early early JJ cord-287815-alv30uk5 280 10 endosome endosome NN cord-287815-alv30uk5 280 11 elements element NNS cord-287815-alv30uk5 280 12 can can MD cord-287815-alv30uk5 280 13 fuse fuse VB cord-287815-alv30uk5 280 14 avidly avidly RB cord-287815-alv30uk5 280 15 with with IN cord-287815-alv30uk5 280 16 each each DT cord-287815-alv30uk5 280 17 other other JJ cord-287815-alv30uk5 280 18 ( ( -LRB- cord-287815-alv30uk5 280 19 Gruenberg Gruenberg NNP cord-287815-alv30uk5 280 20 and and CC cord-287815-alv30uk5 280 21 Howell Howell NNP cord-287815-alv30uk5 280 22 , , , cord-287815-alv30uk5 280 23 1989 1989 CD cord-287815-alv30uk5 280 24 ) ) -RRB- cord-287815-alv30uk5 280 25 . . . cord-287815-alv30uk5 281 1 Other other JJ cord-287815-alv30uk5 281 2 examples example NNS cord-287815-alv30uk5 281 3 of of IN cord-287815-alv30uk5 281 4 processes process NNS cord-287815-alv30uk5 281 5 involving involve VBG cord-287815-alv30uk5 281 6 homotypic homotypic JJ cord-287815-alv30uk5 281 7 fusion fusion NN cord-287815-alv30uk5 281 8 in in IN cord-287815-alv30uk5 281 9 vitro vitro FW cord-287815-alv30uk5 281 10 are be VBP cord-287815-alv30uk5 281 11 the the DT cord-287815-alv30uk5 281 12 assembly assembly NN cord-287815-alv30uk5 281 13 of of IN cord-287815-alv30uk5 281 14 the the DT cord-287815-alv30uk5 281 15 nuclear nuclear JJ cord-287815-alv30uk5 281 16 envelope envelope NN cord-287815-alv30uk5 281 17 ( ( -LRB- cord-287815-alv30uk5 281 18 Burke Burke NNP cord-287815-alv30uk5 281 19 and and CC cord-287815-alv30uk5 281 20 Gerace Gerace NNP cord-287815-alv30uk5 281 21 , , , cord-287815-alv30uk5 281 22 1986 1986 CD cord-287815-alv30uk5 281 23 ) ) -RRB- cord-287815-alv30uk5 281 24 and and CC cord-287815-alv30uk5 281 25 the the DT cord-287815-alv30uk5 281 26 formation formation NN cord-287815-alv30uk5 281 27 of of IN cord-287815-alv30uk5 281 28 ER ER NNP cord-287815-alv30uk5 281 29 ( ( -LRB- cord-287815-alv30uk5 281 30 Dabora Dabora NNP cord-287815-alv30uk5 281 31 and and CC cord-287815-alv30uk5 281 32 Sheetz Sheetz NNP cord-287815-alv30uk5 281 33 , , , cord-287815-alv30uk5 281 34 1988 1988 CD cord-287815-alv30uk5 281 35 ) ) -RRB- cord-287815-alv30uk5 281 36 . . . cord-287815-alv30uk5 282 1 The the DT cord-287815-alv30uk5 282 2 Golgi Golgi NNP cord-287815-alv30uk5 282 3 complex complex NN cord-287815-alv30uk5 282 4 is be VBZ cord-287815-alv30uk5 282 5 also also RB cord-287815-alv30uk5 282 6 a a DT cord-287815-alv30uk5 282 7 dynamic dynamic JJ cord-287815-alv30uk5 282 8 structure structure NN cord-287815-alv30uk5 282 9 that that WDT cord-287815-alv30uk5 282 10 can can MD cord-287815-alv30uk5 282 11 be be VB cord-287815-alv30uk5 282 12 disassembled disassemble VBN cord-287815-alv30uk5 282 13 by by IN cord-287815-alv30uk5 282 14 microtubule microtubule JJ cord-287815-alv30uk5 282 15 depolymerization depolymerization NN cord-287815-alv30uk5 282 16 into into IN cord-287815-alv30uk5 282 17 fragments fragment NNS cord-287815-alv30uk5 282 18 that that WDT cord-287815-alv30uk5 282 19 remain remain VBP cord-287815-alv30uk5 282 20 functional functional JJ cord-287815-alv30uk5 282 21 despite despite IN cord-287815-alv30uk5 282 22 being be VBG cord-287815-alv30uk5 282 23 dispersed disperse VBN cord-287815-alv30uk5 282 24 throughout throughout IN cord-287815-alv30uk5 282 25 the the DT cord-287815-alv30uk5 282 26 cytoplasm cytoplasm NN cord-287815-alv30uk5 282 27 ( ( -LRB- cord-287815-alv30uk5 282 28 Thyberg Thyberg NNP cord-287815-alv30uk5 282 29 and and CC cord-287815-alv30uk5 282 30 Moskalewski Moskalewski NNP cord-287815-alv30uk5 282 31 , , , cord-287815-alv30uk5 282 32 1985 1985 CD cord-287815-alv30uk5 282 33 ) ) -RRB- cord-287815-alv30uk5 282 34 . . . cord-287815-alv30uk5 283 1 Upon upon IN cord-287815-alv30uk5 283 2 microtubule microtubule NN cord-287815-alv30uk5 283 3 reassembly reassembly RB cord-287815-alv30uk5 283 4 , , , cord-287815-alv30uk5 283 5 the the DT cord-287815-alv30uk5 283 6 Golgi Golgi NNP cord-287815-alv30uk5 283 7 fragments fragment NNS cord-287815-alv30uk5 283 8 rapidly rapidly RB cord-287815-alv30uk5 283 9 reassemble reassemble VBP cord-287815-alv30uk5 283 10 and and CC cord-287815-alv30uk5 283 11 assume assume VBP cord-287815-alv30uk5 283 12 their -PRON- PRP$ cord-287815-alv30uk5 283 13 characteristic characteristic JJ cord-287815-alv30uk5 283 14 cisternal cisternal JJ cord-287815-alv30uk5 283 15 organization organization NN cord-287815-alv30uk5 283 16 ( ( -LRB- cord-287815-alv30uk5 283 17 Ho Ho NNP cord-287815-alv30uk5 283 18 et et FW cord-287815-alv30uk5 283 19 al al NNP cord-287815-alv30uk5 283 20 . . NNP cord-287815-alv30uk5 283 21 , , , cord-287815-alv30uk5 283 22 1989 1989 CD cord-287815-alv30uk5 283 23 ) ) -RRB- cord-287815-alv30uk5 283 24 . . . cord-287815-alv30uk5 284 1 A a DT cord-287815-alv30uk5 284 2 similar similar JJ cord-287815-alv30uk5 284 3 series series NN cord-287815-alv30uk5 284 4 of of IN cord-287815-alv30uk5 284 5 events event NNS cord-287815-alv30uk5 284 6 must must MD cord-287815-alv30uk5 284 7 occur occur VB cord-287815-alv30uk5 284 8 during during IN cord-287815-alv30uk5 284 9 mitosis mitosis NN cord-287815-alv30uk5 284 10 when when WRB cord-287815-alv30uk5 284 11 the the DT cord-287815-alv30uk5 284 12 Golgi Golgi NNP cord-287815-alv30uk5 284 13 fragments fragment NNS cord-287815-alv30uk5 284 14 into into IN cord-287815-alv30uk5 284 15 populations population NNS cord-287815-alv30uk5 284 16 of of IN cord-287815-alv30uk5 284 17 small small JJ cord-287815-alv30uk5 284 18 vesicles vesicle NNS cord-287815-alv30uk5 284 19 and and CC cord-287815-alv30uk5 284 20 tubules tubule NNS cord-287815-alv30uk5 284 21 ( ( -LRB- cord-287815-alv30uk5 284 22 Lucocq Lucocq NNP cord-287815-alv30uk5 284 23 et et FW cord-287815-alv30uk5 284 24 al al NNP cord-287815-alv30uk5 284 25 . . NNP cord-287815-alv30uk5 284 26 , , , cord-287815-alv30uk5 284 27 1989 1989 CD cord-287815-alv30uk5 284 28 ) ) -RRB- cord-287815-alv30uk5 284 29 . . . cord-287815-alv30uk5 285 1 During during IN cord-287815-alv30uk5 285 2 telophase telophase NN cord-287815-alv30uk5 285 3 , , , cord-287815-alv30uk5 285 4 these these DT cord-287815-alv30uk5 285 5 fragments fragment NNS cord-287815-alv30uk5 285 6 reassemble reassemble VBP cord-287815-alv30uk5 285 7 . . . cord-287815-alv30uk5 286 1 Given give VBN cord-287815-alv30uk5 286 2 that that IN cord-287815-alv30uk5 286 3 homotypic homotypic JJ cord-287815-alv30uk5 286 4 fusion fusion NN cord-287815-alv30uk5 286 5 occurs occur VBZ cord-287815-alv30uk5 286 6 so so RB cord-287815-alv30uk5 286 7 commonly commonly RB cord-287815-alv30uk5 286 8 , , , cord-287815-alv30uk5 286 9 it -PRON- PRP cord-287815-alv30uk5 286 10 would would MD cord-287815-alv30uk5 286 11 be be VB cord-287815-alv30uk5 286 12 premature premature JJ cord-287815-alv30uk5 286 13 to to TO cord-287815-alv30uk5 286 14 dismiss dismiss VB cord-287815-alv30uk5 286 15 the the DT cord-287815-alv30uk5 286 16 possibility possibility NN cord-287815-alv30uk5 286 17 that that IN cord-287815-alv30uk5 286 18 the the DT cord-287815-alv30uk5 286 19 intra intra JJ cord-287815-alv30uk5 286 20 - - JJ cord-287815-alv30uk5 286 21 Golgi golgi JJ cord-287815-alv30uk5 286 22 transport transport NN cord-287815-alv30uk5 286 23 activity activity NN cord-287815-alv30uk5 286 24 observed observe VBN cord-287815-alv30uk5 286 25 in in IN cord-287815-alv30uk5 286 26 vitro vitro FW cord-287815-alv30uk5 286 27 actually actually RB cord-287815-alv30uk5 286 28 reflects reflect VBZ cord-287815-alv30uk5 286 29 a a DT cord-287815-alv30uk5 286 30 process process NN cord-287815-alv30uk5 286 31 of of IN cord-287815-alv30uk5 286 32 regulated regulated JJ cord-287815-alv30uk5 286 33 tubule tubule NN cord-287815-alv30uk5 286 34 formation formation NN cord-287815-alv30uk5 286 35 and/or and/or CC cord-287815-alv30uk5 286 36 direct direct JJ cord-287815-alv30uk5 286 37 fusion fusion NN cord-287815-alv30uk5 286 38 of of IN cord-287815-alv30uk5 286 39 donor donor NN cord-287815-alv30uk5 286 40 and and CC cord-287815-alv30uk5 286 41 acceptor acceptor NN cord-287815-alv30uk5 286 42 Golgi Golgi NNP cord-287815-alv30uk5 286 43 elements element NNS cord-287815-alv30uk5 286 44 ( ( -LRB- cord-287815-alv30uk5 286 45 Figure figure NN cord-287815-alv30uk5 286 46 4 4 CD cord-287815-alv30uk5 286 47 ) ) -RRB- cord-287815-alv30uk5 286 48 . . . cord-287815-alv30uk5 287 1 Indeed indeed RB cord-287815-alv30uk5 287 2 , , , cord-287815-alv30uk5 287 3 even even RB cord-287815-alv30uk5 287 4 in in IN cord-287815-alv30uk5 287 5 untreated untreated JJ cord-287815-alv30uk5 287 6 Golgi Golgi NNP cord-287815-alv30uk5 287 7 , , , cord-287815-alv30uk5 287 8 both both DT cord-287815-alv30uk5 287 9 in in IN cord-287815-alv30uk5 287 10 vitro vitro FW cord-287815-alv30uk5 287 11 and and CC cord-287815-alv30uk5 287 12 in in IN cord-287815-alv30uk5 287 13 intact intact JJ cord-287815-alv30uk5 287 14 cells cell NNS cord-287815-alv30uk5 287 15 , , , cord-287815-alv30uk5 287 16 tubules tubule NNS cord-287815-alv30uk5 287 17 can can MD cord-287815-alv30uk5 287 18 be be VB cord-287815-alv30uk5 287 19 found find VBN cord-287815-alv30uk5 287 20 that that WDT cord-287815-alv30uk5 287 21 are be VBP cord-287815-alv30uk5 287 22 similar similar JJ cord-287815-alv30uk5 287 23 to to IN cord-287815-alv30uk5 287 24 those those DT cord-287815-alv30uk5 287 25 observed observe VBN cord-287815-alv30uk5 287 26 in in IN cord-287815-alv30uk5 287 27 BFA BFA NNP cord-287815-alv30uk5 287 28 - - HYPH cord-287815-alv30uk5 287 29 treated treat VBN cord-287815-alv30uk5 287 30 Golgi Golgi NNP cord-287815-alv30uk5 288 1 ( ( -LRB- cord-287815-alv30uk5 288 2 Hermo Hermo NNP cord-287815-alv30uk5 288 3 et et NNP cord-287815-alv30uk5 288 4 al al NNP cord-287815-alv30uk5 288 5 . . NNP cord-287815-alv30uk5 288 6 , , , cord-287815-alv30uk5 288 7 1980 1980 CD cord-287815-alv30uk5 289 1 ; ; : cord-287815-alv30uk5 289 2 Braell Braell NNP cord-287815-alv30uk5 289 3 et et NNP cord-287815-alv30uk5 289 4 al al NNP cord-287815-alv30uk5 289 5 . . . cord-287815-alv30uk5 290 1 , , , cord-287815-alv30uk5 290 2 1984 1984 CD cord-287815-alv30uk5 290 3 [ [ -LRB- cord-287815-alv30uk5 290 4 see see VB cord-287815-alv30uk5 290 5 Figure figure NN cord-287815-alv30uk5 290 6 8b 8b NN cord-287815-alv30uk5 290 7 in in IN cord-287815-alv30uk5 290 8 this this DT cord-287815-alv30uk5 290 9 reference reference NN cord-287815-alv30uk5 290 10 ] ] -RRB- cord-287815-alv30uk5 290 11 ; ; . cord-287815-alv30uk5 291 1 Griffiths Griffiths NNP cord-287815-alv30uk5 291 2 et et NNP cord-287815-alv30uk5 291 3 al al NNP cord-287815-alv30uk5 291 4 . . NNP cord-287815-alv30uk5 291 5 , , , cord-287815-alv30uk5 291 6 1985 1985 CD cord-287815-alv30uk5 291 7 ) ) -RRB- cord-287815-alv30uk5 291 8 . . . cord-287815-alv30uk5 292 1 That that IN cord-287815-alv30uk5 292 2 a a DT cord-287815-alv30uk5 292 3 direct direct JJ cord-287815-alv30uk5 292 4 fusion fusion NN cord-287815-alv30uk5 292 5 event event NN cord-287815-alv30uk5 292 6 is be VBZ cord-287815-alv30uk5 292 7 possible possible JJ cord-287815-alv30uk5 292 8 is be VBZ cord-287815-alv30uk5 292 9 also also RB cord-287815-alv30uk5 292 10 suggested suggest VBN cord-287815-alv30uk5 292 11 by by IN cord-287815-alv30uk5 292 12 the the DT cord-287815-alv30uk5 292 13 fact fact NN cord-287815-alv30uk5 292 14 that that IN cord-287815-alv30uk5 292 15 the the DT cord-287815-alv30uk5 292 16 predicted predict VBN cord-287815-alv30uk5 292 17 diffusion diffusion NN cord-287815-alv30uk5 292 18 coefficient coefficient NN cord-287815-alv30uk5 292 19 of of IN cord-287815-alv30uk5 292 20 intact intact JJ cord-287815-alv30uk5 292 21 Golgi Golgi NNP cord-287815-alv30uk5 292 22 stacks stack NNS cord-287815-alv30uk5 292 23 is be VBZ cord-287815-alv30uk5 292 24 ~1 ~1 DT cord-287815-alv30uk5 292 25 O o UH cord-287815-alv30uk5 292 26 - - RB cord-287815-alv30uk5 292 27 fold fold VB cord-287815-alv30uk5 292 28 less less RBR cord-287815-alv30uk5 292 29 than than IN cord-287815-alv30uk5 292 30 that that DT cord-287815-alv30uk5 292 31 of of IN cord-287815-alv30uk5 292 32 the the DT cord-287815-alv30uk5 292 33 much much RB cord-287815-alv30uk5 292 34 smaller small JJR cord-287815-alv30uk5 292 35 coated coat VBN cord-287815-alv30uk5 292 36 vesicles vesicle NNS cord-287815-alv30uk5 292 37 ( ( -LRB- cord-287815-alv30uk5 292 38 N. N. NNP cord-287815-alv30uk5 292 39 Ktistakis Ktistakis NNP cord-287815-alv30uk5 292 40 , , , cord-287815-alv30uk5 292 41 unpublished unpublished JJ cord-287815-alv30uk5 292 42 data datum NNS cord-287815-alv30uk5 292 43 ) ) -RRB- cord-287815-alv30uk5 292 44 . . . cord-287815-alv30uk5 293 1 Thus thus RB cord-287815-alv30uk5 293 2 , , , cord-287815-alv30uk5 293 3 one one PRP cord-287815-alv30uk5 293 4 might may MD cord-287815-alv30uk5 293 5 expect expect VB cord-287815-alv30uk5 293 6 a a DT cord-287815-alv30uk5 293 7 decrease decrease NN cord-287815-alv30uk5 293 8 in in IN cord-287815-alv30uk5 293 9 the the DT cord-287815-alv30uk5 293 10 kinetics kinetic NNS cord-287815-alv30uk5 293 11 of of IN cord-287815-alv30uk5 293 12 VSV VSV NNP cord-287815-alv30uk5 293 13 G G NNP cord-287815-alv30uk5 293 14 protein protein NN cord-287815-alv30uk5 293 15 transfer transfer NN cord-287815-alv30uk5 293 16 if if IN cord-287815-alv30uk5 293 17 BFA BFA NNP cord-287815-alv30uk5 293 18 were be VBD cord-287815-alv30uk5 293 19 to to TO cord-287815-alv30uk5 293 20 switch switch VB cord-287815-alv30uk5 293 21 the the DT cord-287815-alv30uk5 293 22 signal signal NN cord-287815-alv30uk5 293 23 generated generate VBN cord-287815-alv30uk5 293 24 in in IN cord-287815-alv30uk5 293 25 vitro vitro FW cord-287815-alv30uk5 293 26 from from IN cord-287815-alv30uk5 293 27 a a DT cord-287815-alv30uk5 293 28 vesicle vesicle NN cord-287815-alv30uk5 293 29 - - HYPH cord-287815-alv30uk5 293 30 dependent dependent JJ cord-287815-alv30uk5 293 31 phenomenon phenomenon NN cord-287815-alv30uk5 293 32 ( ( -LRB- cord-287815-alv30uk5 293 33 as as IN cord-287815-alv30uk5 293 34 is be VBZ cord-287815-alv30uk5 293 35 presumed presume VBN cord-287815-alv30uk5 293 36 to to TO cord-287815-alv30uk5 293 37 occur occur VB cord-287815-alv30uk5 293 38 in in IN cord-287815-alv30uk5 293 39 the the DT cord-287815-alv30uk5 293 40 absence absence NN cord-287815-alv30uk5 293 41 of of IN cord-287815-alv30uk5 293 42 the the DT cord-287815-alv30uk5 293 43 drug drug NN cord-287815-alv30uk5 293 44 ) ) -RRB- cord-287815-alv30uk5 293 45 to to IN cord-287815-alv30uk5 293 46 a a DT cord-287815-alv30uk5 293 47 direct direct JJ cord-287815-alv30uk5 293 48 , , , cord-287815-alv30uk5 293 49 tubule tubule NN cord-287815-alv30uk5 293 50 - - HYPH cord-287815-alv30uk5 293 51 mediated mediate VBN cord-287815-alv30uk5 293 52 fusion fusion NN cord-287815-alv30uk5 293 53 event event NN cord-287815-alv30uk5 293 54 . . . cord-287815-alv30uk5 294 1 However however RB cord-287815-alv30uk5 294 2 , , , cord-287815-alv30uk5 294 3 G g NN cord-287815-alv30uk5 294 4 protein protein NN cord-287815-alv30uk5 294 5 is be VBZ cord-287815-alv30uk5 294 6 transported transport VBN cord-287815-alv30uk5 294 7 from from IN cord-287815-alv30uk5 294 8 donor donor NN cord-287815-alv30uk5 294 9 to to IN cord-287815-alv30uk5 294 10 acceptor acceptor NN cord-287815-alv30uk5 294 11 with with IN cord-287815-alv30uk5 294 12 the the DT cord-287815-alv30uk5 294 13 same same JJ cord-287815-alv30uk5 294 14 kinetics kinetic NNS cord-287815-alv30uk5 294 15 in in IN cord-287815-alv30uk5 294 16 the the DT cord-287815-alv30uk5 294 17 presence presence NN cord-287815-alv30uk5 294 18 or or CC cord-287815-alv30uk5 294 19 absence absence NN cord-287815-alv30uk5 294 20 of of IN cord-287815-alv30uk5 294 21 BFA BFA NNP cord-287815-alv30uk5 294 22 . . . cord-287815-alv30uk5 295 1 Finally finally RB cord-287815-alv30uk5 295 2 , , , cord-287815-alv30uk5 295 3 the the DT cord-287815-alv30uk5 295 4 fact fact NN cord-287815-alv30uk5 295 5 that that IN cord-287815-alv30uk5 295 6 the the DT cord-287815-alv30uk5 295 7 two two CD cord-287815-alv30uk5 295 8 N n NN cord-287815-alv30uk5 295 9 - - HYPH cord-287815-alv30uk5 295 10 linked link VBN cord-287815-alv30uk5 295 11 chains chain NNS cord-287815-alv30uk5 295 12 of of IN cord-287815-alv30uk5 295 13 VSV VSV NNP cord-287815-alv30uk5 295 14 G G NNP cord-287815-alv30uk5 295 15 protein protein NN cord-287815-alv30uk5 295 16 are be VBP cord-287815-alv30uk5 295 17 processed process VBN cord-287815-alv30uk5 295 18 simultaneously simultaneously RB cord-287815-alv30uk5 295 19 in in IN cord-287815-alv30uk5 295 20 vitro vitro FW cord-287815-alv30uk5 295 21 as as IN cord-287815-alv30uk5 295 22 opposed oppose VBN cord-287815-alv30uk5 295 23 to to IN cord-287815-alv30uk5 295 24 sequentially sequentially RB cord-287815-alv30uk5 295 25 in in IN cord-287815-alv30uk5 295 26 permeabilized permeabilized JJ cord-287815-alv30uk5 295 27 cells cell NNS cord-287815-alv30uk5 295 28 may may MD cord-287815-alv30uk5 295 29 also also RB cord-287815-alv30uk5 295 30 indicate indicate VB cord-287815-alv30uk5 295 31 that that IN cord-287815-alv30uk5 295 32 compartmental compartmental JJ cord-287815-alv30uk5 295 33 boundaries boundary NNS cord-287815-alv30uk5 295 34 may may MD cord-287815-alv30uk5 295 35 not not RB cord-287815-alv30uk5 295 36 be be VB cord-287815-alv30uk5 295 37 strictly strictly RB cord-287815-alv30uk5 295 38 preserved preserve VBN cord-287815-alv30uk5 295 39 , , , cord-287815-alv30uk5 295 40 i.e. i.e. FW cord-287815-alv30uk5 295 41 , , , cord-287815-alv30uk5 295 42 that that IN cord-287815-alv30uk5 295 43 direct direct JJ cord-287815-alv30uk5 295 44 fusion fusion NN cord-287815-alv30uk5 295 45 may may MD cord-287815-alv30uk5 295 46 occur occur VB cord-287815-alv30uk5 295 47 , , , cord-287815-alv30uk5 295 48 during during IN cord-287815-alv30uk5 295 49 the the DT cord-287815-alv30uk5 295 50 cell cell NN cord-287815-alv30uk5 295 51 - - HYPH cord-287815-alv30uk5 295 52 free free JJ cord-287815-alv30uk5 295 53 assay assay NN cord-287815-alv30uk5 295 54 ( ( -LRB- cord-287815-alv30uk5 295 55 Schwaninger Schwaninger NNP cord-287815-alv30uk5 295 56 et et NNP cord-287815-alv30uk5 295 57 al al NNP cord-287815-alv30uk5 295 58 . . NNP cord-287815-alv30uk5 295 59 , , , cord-287815-alv30uk5 295 60 1991 1991 CD cord-287815-alv30uk5 295 61 ) ) -RRB- cord-287815-alv30uk5 295 62 . . . cord-287815-alv30uk5 296 1 The the DT cord-287815-alv30uk5 296 2 minimal minimal JJ cord-287815-alv30uk5 296 3 model model NN cord-287815-alv30uk5 296 4 that that WDT cord-287815-alv30uk5 296 5 we -PRON- PRP cord-287815-alv30uk5 296 6 discussed discuss VBD cord-287815-alv30uk5 296 7 ( ( -LRB- cord-287815-alv30uk5 296 8 see see VB cord-287815-alv30uk5 296 9 Figure figure NN cord-287815-alv30uk5 296 10 3 3 CD cord-287815-alv30uk5 296 11 ) ) -RRB- cord-287815-alv30uk5 296 12 predicts predict VBZ cord-287815-alv30uk5 296 13 only only RB cord-287815-alv30uk5 296 14 two two CD cord-287815-alv30uk5 296 15 functional functional JJ cord-287815-alv30uk5 296 16 and and CC cord-287815-alv30uk5 296 17 presumably presumably RB cord-287815-alv30uk5 296 18 physical physical JJ cord-287815-alv30uk5 296 19 discontinuities discontinuity NNS cord-287815-alv30uk5 296 20 in in IN cord-287815-alv30uk5 296 21 theGolgi thegolgi NN cord-287815-alv30uk5 296 22 : : : cord-287815-alv30uk5 296 23 from from IN cord-287815-alv30uk5 296 24 theCGN theCGN NNP cord-287815-alv30uk5 296 25 to to IN cord-287815-alv30uk5 296 26 the the DT cord-287815-alv30uk5 296 27 medial medial JJ cord-287815-alv30uk5 296 28 Golgi Golgi NNP cord-287815-alv30uk5 296 29 , , , cord-287815-alv30uk5 296 30 and and CC cord-287815-alv30uk5 296 31 from from IN cord-287815-alv30uk5 296 32 the the DT cord-287815-alv30uk5 296 33 medial medial JJ cord-287815-alv30uk5 296 34 Golgi Golgi NNP cord-287815-alv30uk5 296 35 to to IN cord-287815-alv30uk5 296 36 the the DT cord-287815-alv30uk5 296 37 TGN TGN NNP cord-287815-alv30uk5 296 38 . . . cord-287815-alv30uk5 297 1 Thus thus RB cord-287815-alv30uk5 297 2 , , , cord-287815-alv30uk5 297 3 according accord VBG cord-287815-alv30uk5 297 4 to to IN cord-287815-alv30uk5 297 5 this this DT cord-287815-alv30uk5 297 6 view view NN cord-287815-alv30uk5 297 7 , , , cord-287815-alv30uk5 297 8 transport transport NN cord-287815-alv30uk5 297 9 through through IN cord-287815-alv30uk5 297 10 the the DT cord-287815-alv30uk5 297 11 Golgi Golgi NNP cord-287815-alv30uk5 297 12 involves involve VBZ cord-287815-alv30uk5 297 13 two two CD cord-287815-alv30uk5 297 14 intercompartmental intercompartmental JJ cord-287815-alv30uk5 297 15 transfers transfer NNS cord-287815-alv30uk5 297 16 , , , cord-287815-alv30uk5 297 17 reflecting reflect VBG cord-287815-alv30uk5 297 18 transfer transfer NN cord-287815-alv30uk5 297 19 from from IN cord-287815-alv30uk5 297 20 the the DT cord-287815-alv30uk5 297 21 site site NN cord-287815-alv30uk5 297 22 of of IN cord-287815-alv30uk5 297 23 entry entry NN cord-287815-alv30uk5 297 24 to to IN cord-287815-alv30uk5 297 25 the the DT cord-287815-alv30uk5 297 26 site site NN cord-287815-alv30uk5 297 27 of of IN cord-287815-alv30uk5 297 28 glycosylation glycosylation NN cord-287815-alv30uk5 297 29 , , , cord-287815-alv30uk5 297 30 and and CC cord-287815-alv30uk5 297 31 from from IN cord-287815-alv30uk5 297 32 the the DT cord-287815-alv30uk5 297 33 site site NN cord-287815-alv30uk5 297 34 of of IN cord-287815-alv30uk5 297 35 glycosylation glycosylation NN cord-287815-alv30uk5 297 36 to to IN cord-287815-alv30uk5 297 37 the the DT cord-287815-alv30uk5 297 38 site site NN cord-287815-alv30uk5 297 39 of of IN cord-287815-alv30uk5 297 40 exit exit NN cord-287815-alv30uk5 297 41 . . . cord-287815-alv30uk5 298 1 Considering consider VBG cord-287815-alv30uk5 298 2 available available JJ cord-287815-alv30uk5 298 3 data datum NNS cord-287815-alv30uk5 298 4 , , , cord-287815-alv30uk5 298 5 we -PRON- PRP cord-287815-alv30uk5 298 6 consider consider VBP cord-287815-alv30uk5 298 7 it -PRON- PRP cord-287815-alv30uk5 298 8 likely likely JJ cord-287815-alv30uk5 298 9 that that IN cord-287815-alv30uk5 298 10 the the DT cord-287815-alv30uk5 298 11 intercompartmental intercompartmental JJ cord-287815-alv30uk5 298 12 transfers transfer NNS cord-287815-alv30uk5 298 13 between between IN cord-287815-alv30uk5 298 14 CGNlmedial cgnlmedial JJ cord-287815-alv30uk5 298 15 and and CC cord-287815-alv30uk5 298 16 medial medial JJ cord-287815-alv30uk5 298 17 / / SYM cord-287815-alv30uk5 298 18 TGN TGN NNP cord-287815-alv30uk5 298 19 boundaries boundary NNS cord-287815-alv30uk5 298 20 occur occur VBP cord-287815-alv30uk5 298 21 in in IN cord-287815-alv30uk5 298 22 vivo vivo NN cord-287815-alv30uk5 298 23 via via IN cord-287815-alv30uk5 298 24 vesicular vesicular JJ cord-287815-alv30uk5 298 25 carriers carrier NNS cord-287815-alv30uk5 298 26 While while IN cord-287815-alv30uk5 298 27 the the DT cord-287815-alv30uk5 298 28 putative putative JJ cord-287815-alv30uk5 298 29 transporters transporter NNS cord-287815-alv30uk5 298 30 remain remain VBP cord-287815-alv30uk5 298 31 to to TO cord-287815-alv30uk5 298 32 be be VB cord-287815-alv30uk5 298 33 identified identify VBN cord-287815-alv30uk5 298 34 , , , cord-287815-alv30uk5 298 35 the the DT cord-287815-alv30uk5 298 36 P p NN cord-287815-alv30uk5 298 37 - - HYPH cord-287815-alv30uk5 298 38 COP cop NN cord-287815-alv30uk5 298 39 - - HYPH cord-287815-alv30uk5 298 40 containing contain VBG cord-287815-alv30uk5 298 41 vesicles vesicle NNS cord-287815-alv30uk5 298 42 Serafini Serafini NNP cord-287815-alv30uk5 298 43 et et NNP cord-287815-alv30uk5 298 44 al al NNP cord-287815-alv30uk5 298 45 . . NNP cord-287815-alv30uk5 298 46 , , , cord-287815-alv30uk5 298 47 1991 1991 CD cord-287815-alv30uk5 298 48 ) ) -RRB- cord-287815-alv30uk5 298 49 are be VBP cord-287815-alv30uk5 298 50 obvious obvious JJ cord-287815-alv30uk5 298 51 but but CC cord-287815-alv30uk5 298 52 unconfirmed unconfirmed JJ cord-287815-alv30uk5 298 53 candidates candidate NNS cord-287815-alv30uk5 298 54 , , , cord-287815-alv30uk5 298 55 whether whether IN cord-287815-alv30uk5 298 56 or or CC cord-287815-alv30uk5 298 57 not not RB cord-287815-alv30uk5 298 58 they -PRON- PRP cord-287815-alv30uk5 298 59 are be VBP cord-287815-alv30uk5 298 60 ultimately ultimately RB cord-287815-alv30uk5 298 61 found find VBN cord-287815-alv30uk5 298 62 to to TO cord-287815-alv30uk5 298 63 function function VB cord-287815-alv30uk5 298 64 as as IN cord-287815-alv30uk5 298 65 carrier carrier NN cord-287815-alv30uk5 298 66 vesicles vesicle NNS cord-287815-alv30uk5 298 67 in in IN cord-287815-alv30uk5 298 68 in in IN cord-287815-alv30uk5 298 69 vitro vitro FW cord-287815-alv30uk5 298 70 Golgi golgi NN cord-287815-alv30uk5 298 71 assays assay NNS cord-287815-alv30uk5 298 72 . . . cord-287815-alv30uk5 299 1 The the DT cord-287815-alv30uk5 299 2 tubular tubular JJ cord-287815-alv30uk5 299 3 interconnections interconnection NNS cord-287815-alv30uk5 299 4 known know VBN cord-287815-alv30uk5 299 5 to to TO cord-287815-alv30uk5 299 6 occur occur VB cord-287815-alv30uk5 299 7 in in IN cord-287815-alv30uk5 299 8 the the DT cord-287815-alv30uk5 299 9 Golgi Golgi NNP cord-287815-alv30uk5 299 10 may may MD cord-287815-alv30uk5 299 11 also also RB cord-287815-alv30uk5 299 12 play play VB cord-287815-alv30uk5 299 13 a a DT cord-287815-alv30uk5 299 14 role role NN cord-287815-alv30uk5 299 15 in in IN cord-287815-alv30uk5 299 16 intercompartmental intercompartmental JJ cord-287815-alv30uk5 299 17 transfer transfer NN cord-287815-alv30uk5 299 18 , , , cord-287815-alv30uk5 299 19 but but CC cord-287815-alv30uk5 299 20 we -PRON- PRP cord-287815-alv30uk5 299 21 view view VBP cord-287815-alv30uk5 299 22 these these DT cord-287815-alv30uk5 299 23 as as IN cord-287815-alv30uk5 299 24 probably probably RB cord-287815-alv30uk5 299 25 being be VBG cord-287815-alv30uk5 299 26 more more RBR cord-287815-alv30uk5 299 27 important important JJ cord-287815-alv30uk5 299 28 for for IN cord-287815-alv30uk5 299 29 establishing establish VBG cord-287815-alv30uk5 299 30 and and CC cord-287815-alv30uk5 299 31 maintaining maintain VBG cord-287815-alv30uk5 299 32 intracompartmental intracompartmental JJ cord-287815-alv30uk5 299 33 links link NNS cord-287815-alv30uk5 299 34 that that WDT cord-287815-alv30uk5 299 35 serve serve VBP cord-287815-alv30uk5 299 36 to to TO cord-287815-alv30uk5 299 37 interconnect interconnect VB cord-287815-alv30uk5 299 38 functionally functionally RB cord-287815-alv30uk5 299 39 identical identical JJ cord-287815-alv30uk5 299 40 Golgi Golgi NNP cord-287815-alv30uk5 299 41 compartments compartment NNS cord-287815-alv30uk5 299 42 and and CC cord-287815-alv30uk5 299 43 to to TO cord-287815-alv30uk5 299 44 mix mix VB cord-287815-alv30uk5 299 45 their -PRON- PRP$ cord-287815-alv30uk5 299 46 contents content NNS cord-287815-alv30uk5 299 47 . . . cord-287815-alv30uk5 300 1 These these DT cord-287815-alv30uk5 300 2 tubular tubular JJ cord-287815-alv30uk5 300 3 connections connection NNS cord-287815-alv30uk5 300 4 may may MD cord-287815-alv30uk5 300 5 break break VB cord-287815-alv30uk5 300 6 and and CC cord-287815-alv30uk5 300 7 fuse fuse VB cord-287815-alv30uk5 300 8 continuously continuously RB cord-287815-alv30uk5 300 9 , , , cord-287815-alv30uk5 300 10 accounting account VBG cord-287815-alv30uk5 300 11 for for IN cord-287815-alv30uk5 300 12 the the DT cord-287815-alv30uk5 300 13 dynamic dynamic JJ cord-287815-alv30uk5 300 14 behavior behavior NN cord-287815-alv30uk5 300 15 of of IN cord-287815-alv30uk5 300 16 the the DT cord-287815-alv30uk5 300 17 Golgi Golgi NNP cord-287815-alv30uk5 300 18 complex complex NN cord-287815-alv30uk5 300 19 after after IN cord-287815-alv30uk5 300 20 microtubule microtubule JJ cord-287815-alv30uk5 300 21 disassembly disassembly NN cord-287815-alv30uk5 300 22 and and CC cord-287815-alv30uk5 300 23 reassembly reassembly NN cord-287815-alv30uk5 300 24 . . . cord-287815-alv30uk5 301 1 However however RB cord-287815-alv30uk5 301 2 , , , cord-287815-alv30uk5 301 3 if if IN cord-287815-alv30uk5 301 4 their -PRON- PRP$ cord-287815-alv30uk5 301 5 formation formation NN cord-287815-alv30uk5 301 6 is be VBZ cord-287815-alv30uk5 301 7 tightly tightly RB cord-287815-alv30uk5 301 8 controlled control VBN cord-287815-alv30uk5 301 9 by by IN cord-287815-alv30uk5 301 10 a a DT cord-287815-alv30uk5 301 11 regulated regulated JJ cord-287815-alv30uk5 301 12 process process NN cord-287815-alv30uk5 301 13 of of IN cord-287815-alv30uk5 301 14 assembly assembly NN cord-287815-alv30uk5 301 15 and and CC cord-287815-alv30uk5 301 16 disassembly disassembly NN cord-287815-alv30uk5 301 17 of of IN cord-287815-alv30uk5 301 18 the the DT cord-287815-alv30uk5 301 19 f&COP f&COP NNP cord-287815-alv30uk5 301 20 - - HYPH cord-287815-alv30uk5 301 21 containing contain VBG cord-287815-alv30uk5 301 22 Golgi Golgi NNP cord-287815-alv30uk5 301 23 coat coat NN cord-287815-alv30uk5 301 24 , , , cord-287815-alv30uk5 301 25 even even RB cord-287815-alv30uk5 301 26 tubule tubule NN cord-287815-alv30uk5 301 27 - - HYPH cord-287815-alv30uk5 301 28 based base VBN cord-287815-alv30uk5 301 29 intercompartmental intercompartmental JJ cord-287815-alv30uk5 301 30 transfer transfer NN cord-287815-alv30uk5 301 31 is be VBZ cord-287815-alv30uk5 301 32 not not RB cord-287815-alv30uk5 301 33 inconceivable inconceivable JJ cord-287815-alv30uk5 301 34 . . . cord-287815-alv30uk5 302 1 Moreover moreover RB cord-287815-alv30uk5 302 2 , , , cord-287815-alv30uk5 302 3 whether whether IN cord-287815-alv30uk5 302 4 cell cell NN cord-287815-alv30uk5 302 5 - - HYPH cord-287815-alv30uk5 302 6 free free JJ cord-287815-alv30uk5 302 7 assays assay NNS cord-287815-alv30uk5 302 8 of of IN cord-287815-alv30uk5 302 9 Golgi Golgi NNP cord-287815-alv30uk5 302 10 function function NN cord-287815-alv30uk5 302 11 reflect reflect VBP cord-287815-alv30uk5 302 12 such such PDT cord-287815-alv30uk5 302 13 an an DT cord-287815-alv30uk5 302 14 intercompartmental intercompartmental JJ cord-287815-alv30uk5 302 15 transfer transfer NN cord-287815-alv30uk5 302 16 , , , cord-287815-alv30uk5 302 17 or or CC cord-287815-alv30uk5 302 18 intracompartmental intracompartmental JJ cord-287815-alv30uk5 302 19 transfer transfer NN cord-287815-alv30uk5 302 20 between between IN cord-287815-alv30uk5 302 21 wild wild JJ cord-287815-alv30uk5 302 22 - - HYPH cord-287815-alv30uk5 302 23 type type NN cord-287815-alv30uk5 302 24 and and CC cord-287815-alv30uk5 302 25 mutant mutant JJ cord-287815-alv30uk5 302 26 Golgi Golgi NNP cord-287815-alv30uk5 302 27 , , , cord-287815-alv30uk5 302 28 remains remain VBZ cord-287815-alv30uk5 302 29 to to TO cord-287815-alv30uk5 302 30 be be VB cord-287815-alv30uk5 302 31 solved solve VBN cord-287815-alv30uk5 302 32 . . . cord-287815-alv30uk5 303 1 Only only RB cord-287815-alv30uk5 303 2 further further JJ cord-287815-alv30uk5 303 3 characterization characterization NN cord-287815-alv30uk5 303 4 of of IN cord-287815-alv30uk5 303 5 the the DT cord-287815-alv30uk5 303 6 machinery machinery NN cord-287815-alv30uk5 303 7 responsible responsible JJ cord-287815-alv30uk5 303 8 for for IN cord-287815-alv30uk5 303 9 intra intra JJ cord-287815-alv30uk5 303 10 - - JJ cord-287815-alv30uk5 303 11 Golgi golgi JJ cord-287815-alv30uk5 303 12 transport transport NN cord-287815-alv30uk5 303 13 will will MD cord-287815-alv30uk5 303 14 decide decide VB cord-287815-alv30uk5 303 15 between between IN cord-287815-alv30uk5 303 16 these these DT cord-287815-alv30uk5 303 17 two two CD cord-287815-alv30uk5 303 18 possibilities possibility NNS cord-287815-alv30uk5 303 19 . . . cord-287815-alv30uk5 304 1 Nevertheless nevertheless RB cord-287815-alv30uk5 304 2 , , , cord-287815-alv30uk5 304 3 based base VBN cord-287815-alv30uk5 304 4 on on IN cord-287815-alv30uk5 304 5 the the DT cord-287815-alv30uk5 304 6 evidence evidence NN cord-287815-alv30uk5 304 7 both both CC cord-287815-alv30uk5 304 8 from from IN cord-287815-alv30uk5 304 9 the the DT cord-287815-alv30uk5 304 10 in in FW cord-287815-alv30uk5 304 11 vitro vitro FW cord-287815-alv30uk5 304 12 assays assay NNS cord-287815-alv30uk5 304 13 and and CC cord-287815-alv30uk5 304 14 from from IN cord-287815-alv30uk5 304 15 yeast yeast NN cord-287815-alv30uk5 304 16 genetics genetic NNS cord-287815-alv30uk5 304 17 , , , cord-287815-alv30uk5 304 18 it -PRON- PRP cord-287815-alv30uk5 304 19 is be VBZ cord-287815-alv30uk5 304 20 clear clear JJ cord-287815-alv30uk5 304 21 that that IN cord-287815-alv30uk5 304 22 the the DT cord-287815-alv30uk5 304 23 few few JJ cord-287815-alv30uk5 304 24 proteins protein NNS cord-287815-alv30uk5 304 25 identified identify VBN cord-287815-alv30uk5 304 26 thus thus RB cord-287815-alv30uk5 304 27 far far RB cord-287815-alv30uk5 304 28 , , , cord-287815-alv30uk5 304 29 such such JJ cord-287815-alv30uk5 304 30 as as IN cord-287815-alv30uk5 304 31 NSF NSF NNP cord-287815-alv30uk5 304 32 and and CC cord-287815-alv30uk5 304 33 SNAP snap VB cord-287815-alv30uk5 304 34 , , , cord-287815-alv30uk5 304 35 are be VBP cord-287815-alv30uk5 304 36 generally generally RB cord-287815-alv30uk5 304 37 important important JJ cord-287815-alv30uk5 304 38 elements element NNS cord-287815-alv30uk5 304 39 , , , cord-287815-alv30uk5 304 40 irrespective irrespective RB cord-287815-alv30uk5 304 41 of of IN cord-287815-alv30uk5 304 42 the the DT cord-287815-alv30uk5 304 43 precise precise JJ cord-287815-alv30uk5 304 44 pathways pathway NNS cord-287815-alv30uk5 304 45 or or CC cord-287815-alv30uk5 304 46 whether whether IN cord-287815-alv30uk5 304 47 transport transport NN cord-287815-alv30uk5 304 48 occurs occur VBZ cord-287815-alv30uk5 304 49 via via IN cord-287815-alv30uk5 304 50 vesicles vesicle NNS cord-287815-alv30uk5 304 51 or or CC cord-287815-alv30uk5 304 52 tubules tubule NNS cord-287815-alv30uk5 304 53 . . . cord-287815-alv30uk5 305 1 Is be VBZ cord-287815-alv30uk5 305 2 Transport transport NN cord-287815-alv30uk5 305 3 through through IN cord-287815-alv30uk5 305 4 the the DT cord-287815-alv30uk5 305 5 Golgi Golgi NNP cord-287815-alv30uk5 305 6 Selective selective JJ cord-287815-alv30uk5 305 7 or or CC cord-287815-alv30uk5 305 8 Nonselective nonselective JJ cord-287815-alv30uk5 305 9 ? ? . cord-287815-alv30uk5 306 1 Having have VBG cord-287815-alv30uk5 306 2 considered consider VBN cord-287815-alv30uk5 306 3 the the DT cord-287815-alv30uk5 306 4 evidence evidence NN cord-287815-alv30uk5 306 5 for for IN cord-287815-alv30uk5 306 6 the the DT cord-287815-alv30uk5 306 7 compartmental compartmental JJ cord-287815-alv30uk5 306 8 organization organization NN cord-287815-alv30uk5 306 9 of of IN cord-287815-alv30uk5 306 10 the the DT cord-287815-alv30uk5 306 11 Golgi Golgi NNP cord-287815-alv30uk5 306 12 and and CC cord-287815-alv30uk5 306 13 for for IN cord-287815-alv30uk5 306 14 the the DT cord-287815-alv30uk5 306 15 role role NN cord-287815-alv30uk5 306 16 of of IN cord-287815-alv30uk5 306 17 carrier carrier NN cord-287815-alv30uk5 306 18 vesicles vesicle NNS cord-287815-alv30uk5 306 19 in in IN cord-287815-alv30uk5 306 20 transport transport NN cord-287815-alv30uk5 306 21 , , , cord-287815-alv30uk5 306 22 we -PRON- PRP cord-287815-alv30uk5 306 23 come come VBP cord-287815-alv30uk5 306 24 to to IN cord-287815-alv30uk5 306 25 the the DT cord-287815-alv30uk5 306 26 last last JJ cord-287815-alv30uk5 306 27 of of IN cord-287815-alv30uk5 306 28 the the DT cord-287815-alv30uk5 306 29 three three CD cord-287815-alv30uk5 306 30 general general JJ cord-287815-alv30uk5 306 31 elements element NNS cord-287815-alv30uk5 306 32 underlying underlie VBG cord-287815-alv30uk5 306 33 our -PRON- PRP$ cord-287815-alv30uk5 306 34 view view NN cord-287815-alv30uk5 306 35 of of IN cord-287815-alv30uk5 306 36 Golgi Golgi NNP cord-287815-alv30uk5 306 37 function function NN cord-287815-alv30uk5 306 38 , , , cord-287815-alv30uk5 306 39 namely namely RB cord-287815-alv30uk5 306 40 , , , cord-287815-alv30uk5 307 1 that that DT cord-287815-alv30uk5 307 2 transport transport NN cord-287815-alv30uk5 307 3 of of IN cord-287815-alv30uk5 307 4 passenger passenger NN cord-287815-alv30uk5 307 5 proteins protein NNS cord-287815-alv30uk5 307 6 through through IN cord-287815-alv30uk5 307 7 the the DT cord-287815-alv30uk5 307 8 Golgi Golgi NNP cord-287815-alv30uk5 307 9 is be VBZ cord-287815-alv30uk5 307 10 inherently inherently RB cord-287815-alv30uk5 307 11 nonselective nonselective JJ cord-287815-alv30uk5 307 12 ( ( -LRB- cord-287815-alv30uk5 307 13 Pfeffer Pfeffer NNP cord-287815-alv30uk5 307 14 and and CC cord-287815-alv30uk5 307 15 Rothman Rothman NNP cord-287815-alv30uk5 307 16 , , , cord-287815-alv30uk5 307 17 1987 1987 CD cord-287815-alv30uk5 307 18 ) ) -RRB- cord-287815-alv30uk5 307 19 . . . cord-287815-alv30uk5 308 1 The the DT cord-287815-alv30uk5 308 2 evidence evidence NN cord-287815-alv30uk5 308 3 for for IN cord-287815-alv30uk5 308 4 this this DT cord-287815-alv30uk5 308 5 view view NN cord-287815-alv30uk5 308 6 is be VBZ cord-287815-alv30uk5 308 7 largely largely RB cord-287815-alv30uk5 308 8 indirect indirect JJ cord-287815-alv30uk5 308 9 or or CC cord-287815-alv30uk5 308 10 negative negative JJ cord-287815-alv30uk5 308 11 , , , cord-287815-alv30uk5 308 12 in in IN cord-287815-alv30uk5 308 13 that that DT cord-287815-alv30uk5 308 14 efforts effort NNS cord-287815-alv30uk5 308 15 to to TO cord-287815-alv30uk5 308 16 identify identify VB cord-287815-alv30uk5 308 17 discrete discrete JJ cord-287815-alv30uk5 308 18 signals signal NNS cord-287815-alv30uk5 308 19 on on IN cord-287815-alv30uk5 308 20 proteins protein NNS cord-287815-alv30uk5 308 21 that that WDT cord-287815-alv30uk5 308 22 are be VBP cord-287815-alv30uk5 308 23 required require VBN cord-287815-alv30uk5 308 24 for for IN cord-287815-alv30uk5 308 25 forward forward JJ cord-287815-alv30uk5 308 26 transport transport NN cord-287815-alv30uk5 308 27 have have VBP cord-287815-alv30uk5 308 28 thus thus RB cord-287815-alv30uk5 308 29 far far RB cord-287815-alv30uk5 308 30 been be VBN cord-287815-alv30uk5 308 31 unsuccessful unsuccessful JJ cord-287815-alv30uk5 308 32 . . . cord-287815-alv30uk5 309 1 On on IN cord-287815-alv30uk5 309 2 the the DT cord-287815-alv30uk5 309 3 other other JJ cord-287815-alv30uk5 309 4 hand hand NN cord-287815-alv30uk5 309 5 , , , cord-287815-alv30uk5 309 6 as as IN cord-287815-alv30uk5 309 7 discussed discuss VBN cord-287815-alv30uk5 309 8 above above RB cord-287815-alv30uk5 309 9 , , , cord-287815-alv30uk5 309 10 there there EX cord-287815-alv30uk5 309 11 is be VBZ cord-287815-alv30uk5 309 12 now now RB cord-287815-alv30uk5 309 13 considerable considerable JJ cord-287815-alv30uk5 309 14 evidence evidence NN cord-287815-alv30uk5 309 15 in in IN cord-287815-alv30uk5 309 16 favor favor NN cord-287815-alv30uk5 309 17 of of IN cord-287815-alv30uk5 309 18 several several JJ cord-287815-alv30uk5 309 19 distinct distinct JJ cord-287815-alv30uk5 309 20 " " '' cord-287815-alv30uk5 309 21 retenlion retenlion NN cord-287815-alv30uk5 309 22 signals signal NNS cord-287815-alv30uk5 309 23 " " '' cord-287815-alv30uk5 309 24 that that WDT cord-287815-alv30uk5 309 25 effectively effectively RB cord-287815-alv30uk5 309 26 prevent prevent VBP cord-287815-alv30uk5 309 27 forward forward JJ cord-287815-alv30uk5 309 28 transport transport NN cord-287815-alv30uk5 309 29 of of IN cord-287815-alv30uk5 309 30 membrane membrane NN cord-287815-alv30uk5 309 31 or or CC cord-287815-alv30uk5 309 32 lumenal lumenal JJ cord-287815-alv30uk5 309 33 proteins protein NNS cord-287815-alv30uk5 309 34 after after IN cord-287815-alv30uk5 309 35 reaching reach VBG cord-287815-alv30uk5 309 36 their -PRON- PRP$ cord-287815-alv30uk5 309 37 prescribed prescribed JJ cord-287815-alv30uk5 309 38 destinations destination NNS cord-287815-alv30uk5 309 39 in in IN cord-287815-alv30uk5 309 40 the the DT cord-287815-alv30uk5 309 41 ER ER NNP cord-287815-alv30uk5 309 42 or or CC cord-287815-alv30uk5 309 43 various various JJ cord-287815-alv30uk5 309 44 Golgi Golgi NNP cord-287815-alv30uk5 309 45 compartments compartment NNS cord-287815-alv30uk5 309 46 ( ( -LRB- cord-287815-alv30uk5 309 47 Pelham Pelham NNP cord-287815-alv30uk5 309 48 , , , cord-287815-alv30uk5 309 49 1991 1991 CD cord-287815-alv30uk5 309 50 ) ) -RRB- cord-287815-alv30uk5 309 51 . . . cord-287815-alv30uk5 310 1 If if IN cord-287815-alv30uk5 310 2 this this DT cord-287815-alv30uk5 310 3 view view NN cord-287815-alv30uk5 310 4 is be VBZ cord-287815-alv30uk5 310 5 correct correct JJ cord-287815-alv30uk5 310 6 , , , cord-287815-alv30uk5 310 7 selectivity selectivity NN cord-287815-alv30uk5 310 8 in in IN cord-287815-alv30uk5 310 9 I.ransport i.ransport NN cord-287815-alv30uk5 310 10 through through IN cord-287815-alv30uk5 310 11 the the DT cord-287815-alv30uk5 310 12 secretory secretory JJ cord-287815-alv30uk5 310 13 pathway pathway NN cord-287815-alv30uk5 310 14 may may MD cord-287815-alv30uk5 310 15 occur occur VB cord-287815-alv30uk5 310 16 by by IN cord-287815-alv30uk5 310 17 " " `` cord-287815-alv30uk5 310 18 default default NN cord-287815-alv30uk5 310 19 , , , cord-287815-alv30uk5 310 20 " " '' cord-287815-alv30uk5 310 21 i.e. i.e. FW cord-287815-alv30uk5 310 22 , , , cord-287815-alv30uk5 310 23 transport transport NN cord-287815-alv30uk5 310 24 of of IN cord-287815-alv30uk5 310 25 passenger passenger NN cord-287815-alv30uk5 310 26 proteins protein NNS cord-287815-alv30uk5 310 27 proceeds proceed NNS cord-287815-alv30uk5 310 28 owing owe VBG cord-287815-alv30uk5 310 29 to to IN cord-287815-alv30uk5 310 30 the the DT cord-287815-alv30uk5 310 31 absence absence NN cord-287815-alv30uk5 310 32 of of IN cord-287815-alv30uk5 310 33 a a DT cord-287815-alv30uk5 310 34 retention retention NN cord-287815-alv30uk5 310 35 signal signal NN cord-287815-alv30uk5 310 36 . . . cord-287815-alv30uk5 311 1 This this DT cord-287815-alv30uk5 311 2 concept concept NN cord-287815-alv30uk5 311 3 , , , cord-287815-alv30uk5 311 4 however however RB cord-287815-alv30uk5 311 5 , , , cord-287815-alv30uk5 311 6 is be VBZ cord-287815-alv30uk5 311 7 not not RB cord-287815-alv30uk5 311 8 necessarily necessarily RB cord-287815-alv30uk5 311 9 incompatible incompatible JJ cord-287815-alv30uk5 311 10 with with IN cord-287815-alv30uk5 311 11 the the DT cord-287815-alv30uk5 311 12 existence existence NN cord-287815-alv30uk5 311 13 of of IN cord-287815-alv30uk5 311 14 selective selective JJ cord-287815-alv30uk5 311 15 signals signal NNS cord-287815-alv30uk5 311 16 for for IN cord-287815-alv30uk5 311 17 forward forward JJ cord-287815-alv30uk5 311 18 transport transport NN cord-287815-alv30uk5 311 19 . . . cord-287815-alv30uk5 312 1 It -PRON- PRP cord-287815-alv30uk5 312 2 is be VBZ cord-287815-alv30uk5 312 3 clear clear JJ cord-287815-alv30uk5 312 4 that that IN cord-287815-alv30uk5 312 5 such such JJ cord-287815-alv30uk5 312 6 signals signal NNS cord-287815-alv30uk5 312 7 exist exist VBP cord-287815-alv30uk5 312 8 and and CC cord-287815-alv30uk5 312 9 play play VBP cord-287815-alv30uk5 312 10 an an DT cord-287815-alv30uk5 312 11 important important JJ cord-287815-alv30uk5 312 12 role role NN cord-287815-alv30uk5 312 13 in in IN cord-287815-alv30uk5 312 14 directing direct VBG cord-287815-alv30uk5 312 15 the the DT cord-287815-alv30uk5 312 16 traffic traffic NN cord-287815-alv30uk5 312 17 of of IN cord-287815-alv30uk5 312 18 proteins protein NNS cord-287815-alv30uk5 312 19 as as IN cord-287815-alv30uk5 312 20 they -PRON- PRP cord-287815-alv30uk5 312 21 leave leave VBP cord-287815-alv30uk5 312 22 the the DT cord-287815-alv30uk5 312 23 TGN TGN NNP cord-287815-alv30uk5 312 24 . . . cord-287815-alv30uk5 313 1 Examples example NNS cord-287815-alv30uk5 313 2 include include VBP cord-287815-alv30uk5 313 3 the the DT cord-287815-alv30uk5 313 4 mannose mannose NN cord-287815-alv30uk5 313 5 g g NN cord-287815-alv30uk5 313 6 - - HYPH cord-287815-alv30uk5 313 7 phosphate phosphate NN cord-287815-alv30uk5 313 8 residues residue NNS cord-287815-alv30uk5 313 9 that that WDT cord-287815-alv30uk5 313 10 specify specify VBP cord-287815-alv30uk5 313 11 transport transport NN cord-287815-alv30uk5 313 12 of of IN cord-287815-alv30uk5 313 13 hydrolytic hydrolytic JJ cord-287815-alv30uk5 313 14 enzymes enzyme NNS cord-287815-alv30uk5 313 15 to to IN cord-287815-alv30uk5 313 16 lysosomes lysosome NNS cord-287815-alv30uk5 313 17 and and CC cord-287815-alv30uk5 313 18 Mellman Mellman NNP cord-287815-alv30uk5 313 19 , , , cord-287815-alv30uk5 313 20 1989 1989 CD cord-287815-alv30uk5 313 21 ) ) -RRB- cord-287815-alv30uk5 313 22 and and CC cord-287815-alv30uk5 313 23 the the DT cord-287815-alv30uk5 313 24 cytoplasmic cytoplasmic JJ cord-287815-alv30uk5 313 25 domain domain NN cord-287815-alv30uk5 313 26 determiinants determiinant NNS cord-287815-alv30uk5 313 27 that that WDT cord-287815-alv30uk5 313 28 target target VBP cord-287815-alv30uk5 313 29 newly newly RB cord-287815-alv30uk5 313 30 synthesized synthesize VBN cord-287815-alv30uk5 313 31 membrane membrane NN cord-287815-alv30uk5 313 32 proteins protein NNS cord-287815-alv30uk5 313 33 to to IN cord-287815-alv30uk5 313 34 ithe ithe DT cord-287815-alv30uk5 313 35 basolateral basolateral JJ cord-287815-alv30uk5 313 36 surface surface NN cord-287815-alv30uk5 313 37 of of IN cord-287815-alv30uk5 313 38 polarized polarized JJ cord-287815-alv30uk5 313 39 cells cell NNS cord-287815-alv30uk5 313 40 ( ( -LRB- cord-287815-alv30uk5 313 41 Hunziker Hunziker NNP cord-287815-alv30uk5 313 42 et et NNP cord-287815-alv30uk5 313 43 al al NNP cord-287815-alv30uk5 313 44 . . NNP cord-287815-alv30uk5 313 45 , , , cord-287815-alv30uk5 313 46 1991a 1991a CD cord-287815-alv30uk5 313 47 ; ; : cord-287815-alv30uk5 313 48 Brewer Brewer NNP cord-287815-alv30uk5 313 49 and and CC cord-287815-alv30uk5 313 50 Roth Roth NNP cord-287815-alv30uk5 313 51 , , , cord-287815-alv30uk5 313 52 1991 1991 CD cord-287815-alv30uk5 313 53 ) ) -RRB- cord-287815-alv30uk5 313 54 . . . cord-287815-alv30uk5 314 1 Since since IN cord-287815-alv30uk5 314 2 the the DT cord-287815-alv30uk5 314 3 transport transport NN cord-287815-alv30uk5 314 4 of of IN cord-287815-alv30uk5 314 5 , , , cord-287815-alv30uk5 314 6 fluorescent fluorescent JJ cord-287815-alv30uk5 314 7 lipids lipid NNS cord-287815-alv30uk5 314 8 from from IN cord-287815-alv30uk5 314 9 the the DT cord-287815-alv30uk5 314 10 Golgi Golgi NNP cord-287815-alv30uk5 314 11 to to IN cord-287815-alv30uk5 314 12 the the DT cord-287815-alv30uk5 314 13 plasma plasma NN cord-287815-alv30uk5 314 14 membrane membrane NN cord-287815-alv30uk5 314 15 Iin Iin NNP cord-287815-alv30uk5 314 16 nonpolarized nonpolarized JJ cord-287815-alv30uk5 314 17 cells cell NNS cord-287815-alv30uk5 314 18 occurs occur VBZ cord-287815-alv30uk5 314 19 very very RB cord-287815-alv30uk5 314 20 rapidly rapidly RB cord-287815-alv30uk5 314 21 , , , cord-287815-alv30uk5 314 22 it -PRON- PRP cord-287815-alv30uk5 314 23 is be VBZ cord-287815-alv30uk5 314 24 thought think VBN cord-287815-alv30uk5 314 25 that that IN cord-287815-alv30uk5 314 26 " " `` cord-287815-alv30uk5 314 27 constitutive constitutive JJ cord-287815-alv30uk5 314 28 " " '' cord-287815-alv30uk5 314 29 transport transport NN cord-287815-alv30uk5 314 30 from from IN cord-287815-alv30uk5 314 31 the the DT cord-287815-alv30uk5 314 32 Golgi Golgi NNP cord-287815-alv30uk5 314 33 to to IN cord-287815-alv30uk5 314 34 the the DT cord-287815-alv30uk5 314 35 cell cell NN cord-287815-alv30uk5 314 36 surface surface NN cord-287815-alv30uk5 314 37 may may MD cord-287815-alv30uk5 314 38 not not RB cord-287815-alv30uk5 314 39 require require VB cord-287815-alv30uk5 314 40 specific specific JJ cord-287815-alv30uk5 314 41 signals signal NNS cord-287815-alv30uk5 314 42 . . . cord-287815-alv30uk5 315 1 , , , cord-287815-alv30uk5 315 2 Analogous analogous JJ cord-287815-alv30uk5 315 3 results result NNS cord-287815-alv30uk5 315 4 were be VBD cord-287815-alv30uk5 315 5 obtained obtain VBN cord-287815-alv30uk5 315 6 in in IN cord-287815-alv30uk5 315 7 experiments experiment NNS cord-287815-alv30uk5 315 8 in in IN cord-287815-alv30uk5 315 9 which which WDT cord-287815-alv30uk5 315 10 a a DT cord-287815-alv30uk5 315 11 tripeptide tripeptide NN cord-287815-alv30uk5 315 12 containing contain VBG cord-287815-alv30uk5 315 13 a a DT cord-287815-alv30uk5 315 14 cognate cognate JJ cord-287815-alv30uk5 315 15 site site NN cord-287815-alv30uk5 315 16 for for IN cord-287815-alv30uk5 315 17 N n CD cord-287815-alv30uk5 315 18 - - HYPH cord-287815-alv30uk5 315 19 linked link VBN cord-287815-alv30uk5 315 20 glycosylation glycosylation NN cord-287815-alv30uk5 315 21 presumably presumably RB cord-287815-alv30uk5 315 22 also also RB cord-287815-alv30uk5 315 23 involved involve VBD cord-287815-alv30uk5 315 24 transport transport NN cord-287815-alv30uk5 315 25 from from IN cord-287815-alv30uk5 315 26 the the DT cord-287815-alv30uk5 315 27 ER ER NNP cord-287815-alv30uk5 316 1 ( ( -LRB- cord-287815-alv30uk5 316 2 Wieland Wieland NNP cord-287815-alv30uk5 316 3 et et NNP cord-287815-alv30uk5 316 4 al al NNP cord-287815-alv30uk5 316 5 . . NNP cord-287815-alv30uk5 316 6 , , , cord-287815-alv30uk5 316 7 1987 1987 CD cord-287815-alv30uk5 316 8 ; ; : cord-287815-alv30uk5 316 9 Helms Helms NNP cord-287815-alv30uk5 316 10 et et NNP cord-287815-alv30uk5 316 11 al al NNP cord-287815-alv30uk5 316 12 . . NNP cord-287815-alv30uk5 316 13 , , , cord-287815-alv30uk5 316 14 1990 1990 CD cord-287815-alv30uk5 316 15 ) ) -RRB- cord-287815-alv30uk5 316 16 . . . cord-287815-alv30uk5 317 1 While while IN cord-287815-alv30uk5 317 2 these these DT cord-287815-alv30uk5 317 3 experiments experiment NNS cord-287815-alv30uk5 317 4 suggest suggest VBP cord-287815-alv30uk5 317 5 that that IN cord-287815-alv30uk5 317 6 signals signal NNS cord-287815-alv30uk5 317 7 are be VBP cord-287815-alv30uk5 317 8 not not RB cord-287815-alv30uk5 317 9 necessary necessary JJ cord-287815-alv30uk5 317 10 for for IN cord-287815-alv30uk5 317 11 transport transport NN cord-287815-alv30uk5 317 12 , , , cord-287815-alv30uk5 317 13 the the DT cord-287815-alv30uk5 317 14 fact fact NN cord-287815-alv30uk5 317 15 that that IN cord-287815-alv30uk5 317 16 they -PRON- PRP cord-287815-alv30uk5 317 17 are be VBP cord-287815-alv30uk5 317 18 released release VBN cord-287815-alv30uk5 317 19 with with IN cord-287815-alv30uk5 317 20 rapid rapid JJ cord-287815-alv30uk5 317 21 kinetics kinetics NNP cord-287815-alv30uk5 317 22 does do VBZ cord-287815-alv30uk5 317 23 not not RB cord-287815-alv30uk5 317 24 alone alone RB cord-287815-alv30uk5 317 25 establish establish VB cord-287815-alv30uk5 317 26 the the DT cord-287815-alv30uk5 317 27 absence absence NN cord-287815-alv30uk5 317 28 of of IN cord-287815-alv30uk5 317 29 such such JJ cord-287815-alv30uk5 317 30 signals signal NNS cord-287815-alv30uk5 317 31 . . . cord-287815-alv30uk5 318 1 Experiments experiment NNS cord-287815-alv30uk5 318 2 showing show VBG cord-287815-alv30uk5 318 3 that that IN cord-287815-alv30uk5 318 4 different different JJ cord-287815-alv30uk5 318 5 secretory secretory NN cord-287815-alv30uk5 318 6 and and CC cord-287815-alv30uk5 318 7 membrane membrane NN cord-287815-alv30uk5 318 8 proteins protein NNS cord-287815-alv30uk5 318 9 are be VBP cord-287815-alv30uk5 318 10 transported transport VBN cord-287815-alv30uk5 318 11 with with IN cord-287815-alv30uk5 318 12 different different JJ cord-287815-alv30uk5 318 13 kinetics kinetic NNS cord-287815-alv30uk5 318 14 may may MD cord-287815-alv30uk5 318 15 indicate indicate VB cord-287815-alv30uk5 318 16 that that IN cord-287815-alv30uk5 318 17 signals signal NNS cord-287815-alv30uk5 318 18 or or CC cord-287815-alv30uk5 318 19 receptors receptor NNS cord-287815-alv30uk5 318 20 are be VBP cord-287815-alv30uk5 318 21 involved involve VBN cord-287815-alv30uk5 318 22 in in IN cord-287815-alv30uk5 318 23 forward forward JJ cord-287815-alv30uk5 318 24 transport transport NN cord-287815-alv30uk5 319 1 ( ( -LRB- cord-287815-alv30uk5 319 2 Lodish Lodish NNP cord-287815-alv30uk5 319 3 et et NNP cord-287815-alv30uk5 319 4 al al NNP cord-287815-alv30uk5 319 5 . . NNP cord-287815-alv30uk5 319 6 , , , cord-287815-alv30uk5 319 7 1983 1983 CD cord-287815-alv30uk5 319 8 ; ; : cord-287815-alv30uk5 319 9 Lodish Lodish NNP cord-287815-alv30uk5 319 10 , , , cord-287815-alv30uk5 319 11 1988 1988 CD cord-287815-alv30uk5 319 12 ) ) -RRB- cord-287815-alv30uk5 319 13 . . . cord-287815-alv30uk5 320 1 Similarly similarly RB cord-287815-alv30uk5 320 2 , , , cord-287815-alv30uk5 320 3 the the DT cord-287815-alv30uk5 320 4 suggestion suggestion NN cord-287815-alv30uk5 320 5 that that WDT cord-287815-alv30uk5 320 6 newly newly RB cord-287815-alv30uk5 320 7 synthesized synthesize VBN cord-287815-alv30uk5 320 8 viral viral JJ cord-287815-alv30uk5 320 9 spike spike NN cord-287815-alv30uk5 320 10 glycoproteins glycoprotein NNS cord-287815-alv30uk5 320 11 are be VBP cord-287815-alv30uk5 320 12 present present JJ cord-287815-alv30uk5 320 13 in in IN cord-287815-alv30uk5 320 14 Golgi Golgi NNP cord-287815-alv30uk5 320 15 membranes membrane NNS cord-287815-alv30uk5 320 16 at at IN cord-287815-alv30uk5 320 17 a a DT cord-287815-alv30uk5 320 18 density density NN cord-287815-alv30uk5 320 19 severalfold severalfold RB cord-287815-alv30uk5 320 20 greater great JJR cord-287815-alv30uk5 320 21 than than IN cord-287815-alv30uk5 320 22 in in IN cord-287815-alv30uk5 320 23 the the DT cord-287815-alv30uk5 320 24 ER ER NNP cord-287815-alv30uk5 320 25 is be VBZ cord-287815-alv30uk5 320 26 also also RB cord-287815-alv30uk5 320 27 consistent consistent JJ cord-287815-alv30uk5 320 28 with with IN cord-287815-alv30uk5 320 29 the the DT cord-287815-alv30uk5 320 30 existence existence NN cord-287815-alv30uk5 320 31 of of IN cord-287815-alv30uk5 320 32 signal signal NN cord-287815-alv30uk5 320 33 - - HYPH cord-287815-alv30uk5 320 34 driven drive VBN cord-287815-alv30uk5 320 35 forward forward JJ cord-287815-alv30uk5 320 36 transport transport NN cord-287815-alv30uk5 321 1 ( ( -LRB- cord-287815-alv30uk5 321 2 Griffiths Griffiths NNP cord-287815-alv30uk5 321 3 et et NNP cord-287815-alv30uk5 321 4 al al NNP cord-287815-alv30uk5 321 5 . . NNP cord-287815-alv30uk5 321 6 , , , cord-287815-alv30uk5 321 7 1984 1984 CD cord-287815-alv30uk5 321 8 ) ) -RRB- cord-287815-alv30uk5 321 9 . . . cord-287815-alv30uk5 322 1 However however RB cord-287815-alv30uk5 322 2 , , , cord-287815-alv30uk5 322 3 both both DT cord-287815-alv30uk5 322 4 of of IN cord-287815-alv30uk5 322 5 these these DT cord-287815-alv30uk5 322 6 observations observation NNS cord-287815-alv30uk5 322 7 might may MD cord-287815-alv30uk5 322 8 also also RB cord-287815-alv30uk5 322 9 be be VB cord-287815-alv30uk5 322 10 reconciled reconcile VBN cord-287815-alv30uk5 322 11 with with IN cord-287815-alv30uk5 322 12 a a DT cord-287815-alv30uk5 322 13 nonselective nonselective JJ cord-287815-alv30uk5 322 14 mechanism mechanism NN cord-287815-alv30uk5 322 15 of of IN cord-287815-alv30uk5 322 16 transport transport NN cord-287815-alv30uk5 322 17 . . . cord-287815-alv30uk5 323 1 Given give VBN cord-287815-alv30uk5 323 2 recent recent JJ cord-287815-alv30uk5 323 3 evidence evidence NN cord-287815-alv30uk5 323 4 that that DT cord-287815-alv30uk5 323 5 exit exit NN cord-287815-alv30uk5 323 6 from from IN cord-287815-alv30uk5 323 7 the the DT cord-287815-alv30uk5 323 8 ER ER NNP cord-287815-alv30uk5 323 9 is be VBZ cord-287815-alv30uk5 323 10 linked link VBN cord-287815-alv30uk5 323 11 to to IN cord-287815-alv30uk5 323 12 the the DT cord-287815-alv30uk5 323 13 folding folding NN cord-287815-alv30uk5 323 14 of of IN cord-287815-alv30uk5 323 15 newly newly RB cord-287815-alv30uk5 323 16 synthesized synthesize VBN cord-287815-alv30uk5 323 17 proteins protein NNS cord-287815-alv30uk5 323 18 , , , cord-287815-alv30uk5 323 19 differential differential JJ cord-287815-alv30uk5 323 20 folding folding NN cord-287815-alv30uk5 323 21 rates rate NNS cord-287815-alv30uk5 323 22 among among IN cord-287815-alv30uk5 323 23 proteins protein NNS cord-287815-alv30uk5 323 24 may may MD cord-287815-alv30uk5 323 25 indirectly indirectly RB cord-287815-alv30uk5 323 26 affect affect VB cord-287815-alv30uk5 323 27 their -PRON- PRP$ cord-287815-alv30uk5 323 28 transport transport NN cord-287815-alv30uk5 323 29 kinetics kinetic NNS cord-287815-alv30uk5 323 30 . . . cord-287815-alv30uk5 324 1 Moreover moreover RB cord-287815-alv30uk5 324 2 , , , cord-287815-alv30uk5 324 3 if if IN cord-287815-alv30uk5 324 4 the the DT cord-287815-alv30uk5 324 5 intrinsic intrinsic JJ cord-287815-alv30uk5 324 6 rate rate NN cord-287815-alv30uk5 324 7 of of IN cord-287815-alv30uk5 324 8 transport transport NN cord-287815-alv30uk5 324 9 of of IN cord-287815-alv30uk5 324 10 glycoproteins glycoprotein NNS cord-287815-alv30uk5 324 11 through through IN cord-287815-alv30uk5 324 12 the the DT cord-287815-alv30uk5 324 13 Golgi Golgi NNP cord-287815-alv30uk5 324 14 is be VBZ cord-287815-alv30uk5 324 15 slow slow JJ cord-287815-alv30uk5 324 16 relative relative JJ cord-287815-alv30uk5 324 17 to to IN cord-287815-alv30uk5 324 18 the the DT cord-287815-alv30uk5 324 19 rate rate NN cord-287815-alv30uk5 324 20 of of IN cord-287815-alv30uk5 324 21 ER ER NNP cord-287815-alv30uk5 324 22 exit exit NN cord-287815-alv30uk5 324 23 , , , cord-287815-alv30uk5 324 24 then then RB cord-287815-alv30uk5 324 25 one one PRP cord-287815-alv30uk5 324 26 might may MD cord-287815-alv30uk5 324 27 also also RB cord-287815-alv30uk5 324 28 expect expect VB cord-287815-alv30uk5 324 29 a a DT cord-287815-alv30uk5 324 30 higher high JJR cord-287815-alv30uk5 324 31 concentration concentration NN cord-287815-alv30uk5 324 32 of of IN cord-287815-alv30uk5 324 33 certain certain JJ cord-287815-alv30uk5 324 34 passenger passenger NN cord-287815-alv30uk5 324 35 proteins protein NNS cord-287815-alv30uk5 324 36 in in IN cord-287815-alv30uk5 324 37 the the DT cord-287815-alv30uk5 324 38 Golgi Golgi NNP cord-287815-alv30uk5 324 39 . . . cord-287815-alv30uk5 325 1 At at IN cord-287815-alv30uk5 325 2 present present JJ cord-287815-alv30uk5 325 3 , , , cord-287815-alv30uk5 325 4 most most JJS cord-287815-alv30uk5 325 5 of of IN cord-287815-alv30uk5 325 6 the the DT cord-287815-alv30uk5 325 7 attention attention NN cord-287815-alv30uk5 325 8 paid pay VBN cord-287815-alv30uk5 325 9 to to IN cord-287815-alv30uk5 325 10 the the DT cord-287815-alv30uk5 325 11 question question NN cord-287815-alv30uk5 325 12 of of IN cord-287815-alv30uk5 325 13 signals signal NNS cord-287815-alv30uk5 325 14 in in IN cord-287815-alv30uk5 325 15 transport transport NN cord-287815-alv30uk5 325 16 concerns concern NNS cord-287815-alv30uk5 325 17 ER ER NNP cord-287815-alv30uk5 325 18 to to IN cord-287815-alv30uk5 325 19 Golgi Golgi NNP cord-287815-alv30uk5 325 20 or or CC cord-287815-alv30uk5 325 21 postQolgi postqolgi JJ cord-287815-alv30uk5 325 22 transport transport NN cord-287815-alv30uk5 325 23 . . . cord-287815-alv30uk5 326 1 Whether whether IN cord-287815-alv30uk5 326 2 transport transport NN cord-287815-alv30uk5 326 3 through through IN cord-287815-alv30uk5 326 4 the the DT cord-287815-alv30uk5 326 5 Golgi Golgi NNP cord-287815-alv30uk5 326 6 complex complex NN cord-287815-alv30uk5 326 7 itself -PRON- PRP cord-287815-alv30uk5 326 8 is be VBZ cord-287815-alv30uk5 326 9 selective selective JJ cord-287815-alv30uk5 326 10 or or CC cord-287815-alv30uk5 326 11 nonselective nonselective JJ cord-287815-alv30uk5 326 12 is be VBZ cord-287815-alv30uk5 326 13 still still RB cord-287815-alv30uk5 326 14 an an DT cord-287815-alv30uk5 326 15 open open JJ cord-287815-alv30uk5 326 16 question question NN cord-287815-alv30uk5 326 17 . . . cord-287815-alv30uk5 327 1 After after IN cord-287815-alv30uk5 327 2 years year NNS cord-287815-alv30uk5 327 3 of of IN cord-287815-alv30uk5 327 4 descriptive descriptive JJ cord-287815-alv30uk5 327 5 work work NN cord-287815-alv30uk5 327 6 , , , cord-287815-alv30uk5 327 7 the the DT cord-287815-alv30uk5 327 8 Golgi Golgi NNP cord-287815-alv30uk5 327 9 complex complex NN cord-287815-alv30uk5 327 10 is be VBZ cord-287815-alv30uk5 327 11 slowly slowly RB cord-287815-alv30uk5 327 12 starting start VBG cord-287815-alv30uk5 327 13 to to TO cord-287815-alv30uk5 327 14 reveal reveal VB cord-287815-alv30uk5 327 15 its -PRON- PRP$ cord-287815-alv30uk5 327 16 secrets secret NNS cord-287815-alv30uk5 327 17 . . . cord-287815-alv30uk5 328 1 We -PRON- PRP cord-287815-alv30uk5 328 2 have have VBP cord-287815-alv30uk5 328 3 now now RB cord-287815-alv30uk5 328 4 entered enter VBN cord-287815-alv30uk5 328 5 an an DT cord-287815-alv30uk5 328 6 exciting exciting JJ cord-287815-alv30uk5 328 7 period period NN cord-287815-alv30uk5 328 8 of of IN cord-287815-alv30uk5 328 9 research research NN cord-287815-alv30uk5 328 10 , , , cord-287815-alv30uk5 328 11 during during IN cord-287815-alv30uk5 328 12 which which WDT cord-287815-alv30uk5 328 13 it -PRON- PRP cord-287815-alv30uk5 328 14 will will MD cord-287815-alv30uk5 328 15 become become VB cord-287815-alv30uk5 328 16 possible possible JJ cord-287815-alv30uk5 328 17 to to TO cord-287815-alv30uk5 328 18 define define VB cord-287815-alv30uk5 328 19 the the DT cord-287815-alv30uk5 328 20 molecular molecular JJ cord-287815-alv30uk5 328 21 mechanisms mechanism NNS cord-287815-alv30uk5 328 22 responsible responsible JJ cord-287815-alv30uk5 328 23 for for IN cord-287815-alv30uk5 328 24 generating generate VBG cord-287815-alv30uk5 328 25 and and CC cord-287815-alv30uk5 328 26 maintaining maintain VBG cord-287815-alv30uk5 328 27 Golgi Golgi NNP cord-287815-alv30uk5 328 28 structure structure NN cord-287815-alv30uk5 328 29 and and CC cord-287815-alv30uk5 328 30 function function NN cord-287815-alv30uk5 328 31 . . . cord-287815-alv30uk5 329 1 The the DT cord-287815-alv30uk5 329 2 first first JJ cord-287815-alv30uk5 329 3 phase phase NN cord-287815-alv30uk5 329 4 is be VBZ cord-287815-alv30uk5 329 5 already already RB cord-287815-alv30uk5 329 6 well well RB cord-287815-alv30uk5 329 7 under under IN cord-287815-alv30uk5 329 8 way way NN cord-287815-alv30uk5 329 9 and and CC cord-287815-alv30uk5 329 10 has have VBZ cord-287815-alv30uk5 329 11 been be VBN cord-287815-alv30uk5 329 12 characterized characterize VBN cord-287815-alv30uk5 329 13 by by IN cord-287815-alv30uk5 329 14 a a DT cord-287815-alv30uk5 329 15 search search NN cord-287815-alv30uk5 329 16 for for IN cord-287815-alv30uk5 329 17 essential essential JJ cord-287815-alv30uk5 329 18 bits bit NNS cord-287815-alv30uk5 329 19 and and CC cord-287815-alv30uk5 329 20 pieces piece NNS cord-287815-alv30uk5 329 21 of of IN cord-287815-alv30uk5 329 22 the the DT cord-287815-alv30uk5 329 23 Golgi Golgi NNP cord-287815-alv30uk5 329 24 machinery machinery NN cord-287815-alv30uk5 329 25 , , , cord-287815-alv30uk5 329 26 a a DT cord-287815-alv30uk5 329 27 number number NN cord-287815-alv30uk5 329 28 of of IN cord-287815-alv30uk5 329 29 which which WDT cord-287815-alv30uk5 329 30 have have VBP cord-287815-alv30uk5 329 31 already already RB cord-287815-alv30uk5 329 32 been be VBN cord-287815-alv30uk5 329 33 found find VBN cord-287815-alv30uk5 329 34 ( ( -LRB- cord-287815-alv30uk5 329 35 NSFlsecl8 NSFlsecl8 NNP cord-287815-alv30uk5 329 36 , , , cord-287815-alv30uk5 329 37 aSNAPlsecl7 asnaplsecl7 RB cord-287815-alv30uk5 329 38 , , , cord-287815-alv30uk5 329 39 ( ( -LRB- cord-287815-alv30uk5 329 40 J J NNP cord-287815-alv30uk5 329 41 - - HYPH cord-287815-alv30uk5 329 42 COP COP NNP cord-287815-alv30uk5 329 43 , , , cord-287815-alv30uk5 329 44 ARF[Stearnsetal ARF[Stearnsetal NNP cord-287815-alv30uk5 329 45 . . NNP cord-287815-alv30uk5 329 46 , , , cord-287815-alv30uk5 329 47 19901 19901 CD cord-287815-alv30uk5 329 48 , , , cord-287815-alv30uk5 329 49 rab6p[Goudetal rab6p[Goudetal NNP cord-287815-alv30uk5 329 50 . . NNP cord-287815-alv30uk5 329 51 , , , cord-287815-alv30uk5 329 52 1990 1990 CD cord-287815-alv30uk5 329 53 ] ] -RRB- cord-287815-alv30uk5 329 54 , , . cord-287815-alv30uk5 330 1 sec7p sec7p NNP cord-287815-alv30uk5 331 1 [ [ -LRB- cord-287815-alv30uk5 331 2 Achstetter Achstetter NNP cord-287815-alv30uk5 331 3 et et NNP cord-287815-alv30uk5 331 4 al al NNP cord-287815-alv30uk5 331 5 . . NNP cord-287815-alv30uk5 331 6 , , , cord-287815-alv30uk5 331 7 19881 19881 CD cord-287815-alv30uk5 331 8 , , , cord-287815-alv30uk5 331 9 and and CC cord-287815-alv30uk5 331 10 secl4p secl4p NNP cord-287815-alv30uk5 332 1 [ [ -LRB- cord-287815-alv30uk5 332 2 Bankaitis Bankaitis NNP cord-287815-alv30uk5 332 3 et et NNP cord-287815-alv30uk5 332 4 al al NNP cord-287815-alv30uk5 332 5 . . NNP cord-287815-alv30uk5 332 6 , , , cord-287815-alv30uk5 332 7 199Oj 199oj CD cord-287815-alv30uk5 332 8 ) ) -RRB- cord-287815-alv30uk5 332 9 . . . cord-287815-alv30uk5 333 1 As as IN cord-287815-alv30uk5 333 2 we -PRON- PRP cord-287815-alv30uk5 333 3 have have VBP cord-287815-alv30uk5 333 4 seen see VBN cord-287815-alv30uk5 333 5 , , , cord-287815-alv30uk5 333 6 however however RB cord-287815-alv30uk5 333 7 , , , cord-287815-alv30uk5 333 8 it -PRON- PRP cord-287815-alv30uk5 333 9 is be VBZ cord-287815-alv30uk5 333 10 at at IN cord-287815-alv30uk5 333 11 present present JJ cord-287815-alv30uk5 333 12 difficult difficult JJ cord-287815-alv30uk5 333 13 to to TO cord-287815-alv30uk5 333 14 know know VB cord-287815-alv30uk5 333 15 precisely precisely RB cord-287815-alv30uk5 333 16 what what WP cord-287815-alv30uk5 333 17 steps step NNS cord-287815-alv30uk5 333 18 are be VBP cord-287815-alv30uk5 333 19 controlled control VBN cord-287815-alv30uk5 333 20 by by IN cord-287815-alv30uk5 333 21 each each DT cord-287815-alv30uk5 333 22 of of IN cord-287815-alv30uk5 333 23 these these DT cord-287815-alv30uk5 333 24 components component NNS cord-287815-alv30uk5 333 25 . . . cord-287815-alv30uk5 334 1 Nevertheless nevertheless RB cord-287815-alv30uk5 334 2 , , , cord-287815-alv30uk5 334 3 the the DT cord-287815-alv30uk5 334 4 observed observed JJ cord-287815-alv30uk5 334 5 conservation conservation NN cord-287815-alv30uk5 334 6 of of IN cord-287815-alv30uk5 334 7 Golgi Golgi NNP cord-287815-alv30uk5 334 8 proteins protein NNS cord-287815-alv30uk5 334 9 between between IN cord-287815-alv30uk5 334 10 S. S. NNP cord-287815-alv30uk5 334 11 cerevisiae cerevisiae NNS cord-287815-alv30uk5 334 12 and and CC cord-287815-alv30uk5 334 13 mammals mammal NNS cord-287815-alv30uk5 334 14 is be VBZ cord-287815-alv30uk5 334 15 most most RBS cord-287815-alv30uk5 334 16 encouraging encouraging JJ cord-287815-alv30uk5 334 17 for for IN cord-287815-alv30uk5 334 18 our -PRON- PRP$ cord-287815-alv30uk5 334 19 ability ability NN cord-287815-alv30uk5 334 20 to to TO cord-287815-alv30uk5 334 21 confirm confirm VB cord-287815-alv30uk5 334 22 in in IN cord-287815-alv30uk5 334 23 living living NN cord-287815-alv30uk5 334 24 cells cell NNS cord-287815-alv30uk5 334 25 the the DT cord-287815-alv30uk5 334 26 function function NN cord-287815-alv30uk5 334 27 of of IN cord-287815-alv30uk5 334 28 components component NNS cord-287815-alv30uk5 334 29 identified identify VBN cord-287815-alv30uk5 334 30 in in IN cord-287815-alv30uk5 334 31 vitro vitro FW cord-287815-alv30uk5 334 32 . . . cord-287815-alv30uk5 335 1 The the DT cord-287815-alv30uk5 335 2 combination combination NN cord-287815-alv30uk5 335 3 of of IN cord-287815-alv30uk5 335 4 cell cell NN cord-287815-alv30uk5 335 5 - - HYPH cord-287815-alv30uk5 335 6 free free JJ cord-287815-alv30uk5 335 7 analysis analysis NN cord-287815-alv30uk5 335 8 and and CC cord-287815-alv30uk5 335 9 genetics genetics NN cord-287815-alv30uk5 335 10 has have VBZ cord-287815-alv30uk5 335 11 proven prove VBN cord-287815-alv30uk5 335 12 its -PRON- PRP$ cord-287815-alv30uk5 335 13 worth worth NN cord-287815-alv30uk5 335 14 . . . cord-287815-alv30uk5 336 1 The the DT cord-287815-alv30uk5 336 2 next next JJ cord-287815-alv30uk5 336 3 phase phase NN cord-287815-alv30uk5 336 4 will will MD cord-287815-alv30uk5 336 5 have have VB cord-287815-alv30uk5 336 6 to to TO cord-287815-alv30uk5 336 7 deal deal VB cord-287815-alv30uk5 336 8 with with IN cord-287815-alv30uk5 336 9 the the DT cord-287815-alv30uk5 336 10 questions question NNS cord-287815-alv30uk5 336 11 that that WDT cord-287815-alv30uk5 336 12 have have VBP cord-287815-alv30uk5 336 13 arisen arise VBN cord-287815-alv30uk5 336 14 . . . cord-287815-alv30uk5 337 1 How how WRB cord-287815-alv30uk5 337 2 many many JJ cord-287815-alv30uk5 337 3 Golgi Golgi NNP cord-287815-alv30uk5 337 4 compartments compartment NNS cord-287815-alv30uk5 337 5 are be VBP cord-287815-alv30uk5 337 6 there there RB cord-287815-alv30uk5 337 7 ? ? . cord-287815-alv30uk5 338 1 Are be VBP cord-287815-alv30uk5 338 2 compartment compartment NN cord-287815-alv30uk5 338 3 boundaries boundary NNS cord-287815-alv30uk5 338 4 defined define VBN cord-287815-alv30uk5 338 5 by by IN cord-287815-alv30uk5 338 6 specific specific JJ cord-287815-alv30uk5 338 7 protein protein NN cord-287815-alv30uk5 338 8 frameworks framework NNS cord-287815-alv30uk5 338 9 ? ? . cord-287815-alv30uk5 339 1 If if IN cord-287815-alv30uk5 339 2 so so RB cord-287815-alv30uk5 339 3 , , , cord-287815-alv30uk5 339 4 how how WRB cord-287815-alv30uk5 339 5 do do VBP cord-287815-alv30uk5 339 6 they -PRON- PRP cord-287815-alv30uk5 339 7 function function VB cord-287815-alv30uk5 339 8 and and CC cord-287815-alv30uk5 339 9 how how WRB cord-287815-alv30uk5 339 10 are be VBP cord-287815-alv30uk5 339 11 they -PRON- PRP cord-287815-alv30uk5 339 12 regulated regulate VBN cord-287815-alv30uk5 339 13 ? ? . cord-287815-alv30uk5 340 1 Does do VBZ cord-287815-alv30uk5 340 2 transport transport NN cord-287815-alv30uk5 340 3 between between IN cord-287815-alv30uk5 340 4 Golgi Golgi NNP cord-287815-alv30uk5 340 5 compartments compartment NNS cord-287815-alv30uk5 340 6 require require VBP cord-287815-alv30uk5 340 7 vesicular vesicular JJ cord-287815-alv30uk5 340 8 carriers carrier NNS cord-287815-alv30uk5 340 9 ? ? . cord-287815-alv30uk5 341 1 What what WP cord-287815-alv30uk5 341 2 is be VBZ cord-287815-alv30uk5 341 3 the the DT cord-287815-alv30uk5 341 4 role role NN cord-287815-alv30uk5 341 5 of of IN cord-287815-alv30uk5 341 6 tubules tubule NNS cord-287815-alv30uk5 341 7 ? ? . cord-287815-alv30uk5 342 1 How how WRB cord-287815-alv30uk5 342 2 does do VBZ cord-287815-alv30uk5 342 3 the the DT cord-287815-alv30uk5 342 4 machinery machinery NN cord-287815-alv30uk5 342 5 responsible responsible JJ cord-287815-alv30uk5 342 6 for for IN cord-287815-alv30uk5 342 7 forward forward JJ cord-287815-alv30uk5 342 8 traffic traffic NN cord-287815-alv30uk5 342 9 relate relate VBP cord-287815-alv30uk5 342 10 to to IN cord-287815-alv30uk5 342 11 the the DT cord-287815-alv30uk5 342 12 machinery machinery NN cord-287815-alv30uk5 342 13 controlling control VBG cord-287815-alv30uk5 342 14 homotypic homotypic JJ cord-287815-alv30uk5 342 15 fusion fusion NN cord-287815-alv30uk5 342 16 ? ? . cord-287815-alv30uk5 343 1 How how WRB cord-287815-alv30uk5 343 2 is be VBZ cord-287815-alv30uk5 343 3 specificity specificity NN cord-287815-alv30uk5 343 4 of of IN cord-287815-alv30uk5 343 5 forward forward JJ cord-287815-alv30uk5 343 6 and and CC cord-287815-alv30uk5 343 7 backward backward JJ cord-287815-alv30uk5 343 8 traffic traffic NN cord-287815-alv30uk5 343 9 regulated regulate VBN cord-287815-alv30uk5 343 10 ? ? . cord-287815-alv30uk5 344 1 How how WRB cord-287815-alv30uk5 344 2 does do VBZ cord-287815-alv30uk5 344 3 lipid lipid NN cord-287815-alv30uk5 344 4 composition composition NN cord-287815-alv30uk5 344 5 and and CC cord-287815-alv30uk5 344 6 organization organization NN cord-287815-alv30uk5 344 7 affect affect VBP cord-287815-alv30uk5 344 8 transport transport NN cord-287815-alv30uk5 344 9 ? ? . cord-287815-alv30uk5 345 1 What what WP cord-287815-alv30uk5 345 2 function function NN cord-287815-alv30uk5 345 3 does do VBZ cord-287815-alv30uk5 345 4 the the DT cord-287815-alv30uk5 345 5 stack stack JJ cord-287815-alv30uk5 345 6 structure structure NN cord-287815-alv30uk5 345 7 have have VB cord-287815-alv30uk5 345 8 ? ? . cord-287815-alv30uk5 346 1 How how WRB cord-287815-alv30uk5 346 2 do do VBP cord-287815-alv30uk5 346 3 microtubules microtubule NNS cord-287815-alv30uk5 346 4 interact interact VB cord-287815-alv30uk5 346 5 with with IN cord-287815-alv30uk5 346 6 the the DT cord-287815-alv30uk5 346 7 Golgi Golgi NNP cord-287815-alv30uk5 346 8 elements element NNS cord-287815-alv30uk5 346 9 ? ? . cord-287815-alv30uk5 347 1 The the DT cord-287815-alv30uk5 347 2 challenge challenge NN cord-287815-alv30uk5 347 3 will will MD cord-287815-alv30uk5 347 4 be be VB cord-287815-alv30uk5 347 5 to to TO cord-287815-alv30uk5 347 6 integrate integrate VB cord-287815-alv30uk5 347 7 the the DT cord-287815-alv30uk5 347 8 information information NN cord-287815-alv30uk5 347 9 we -PRON- PRP cord-287815-alv30uk5 347 10 are be VBP cord-287815-alv30uk5 347 11 now now RB cord-287815-alv30uk5 347 12 collecting collect VBG cord-287815-alv30uk5 347 13 in in IN cord-287815-alv30uk5 347 14 the the DT cord-287815-alv30uk5 347 15 context context NN cord-287815-alv30uk5 347 16 of of IN cord-287815-alv30uk5 347 17 how how WRB cord-287815-alv30uk5 347 18 the the DT cord-287815-alv30uk5 347 19 Golgi Golgi NNP cord-287815-alv30uk5 347 20 complex complex NN cord-287815-alv30uk5 347 21 works work VBZ cord-287815-alv30uk5 347 22 as as IN cord-287815-alv30uk5 347 23 a a DT cord-287815-alv30uk5 347 24 whole whole NN cord-287815-alv30uk5 347 25 . . . cord-287815-alv30uk5 348 1 SEC7 SEC7 NNP cord-287815-alv30uk5 348 2 encodes encode VBZ cord-287815-alv30uk5 348 3 an an DT cord-287815-alv30uk5 348 4 unusual unusual JJ cord-287815-alv30uk5 348 5 , , , cord-287815-alv30uk5 348 6 high high JJ cord-287815-alv30uk5 348 7 molecular molecular JJ cord-287815-alv30uk5 348 8 weight weight NN cord-287815-alv30uk5 348 9 protein protein NN cord-287815-alv30uk5 348 10 required require VBN cord-287815-alv30uk5 348 11 for for IN cord-287815-alv30uk5 348 12 membrane membrane NN cord-287815-alv30uk5 348 13 traffic traffic NN cord-287815-alv30uk5 348 14 from from IN cord-287815-alv30uk5 348 15 the the DT cord-287815-alv30uk5 348 16 yeast yeast NN cord-287815-alv30uk5 348 17 Golgi Golgi NNP cord-287815-alv30uk5 348 18 apparatus apparatus NN cord-287815-alv30uk5 348 19 A a DT cord-287815-alv30uk5 348 20 microtubule microtubule NN cord-287815-alv30uk5 348 21 - - HYPH cord-287815-alv30uk5 348 22 binding bind VBG cord-287815-alv30uk5 348 23 protein protein NN cord-287815-alv30uk5 348 24 associated associate VBN cord-287815-alv30uk5 348 25 with with IN cord-287815-alv30uk5 348 26 membranes membrane NNS cord-287815-alv30uk5 348 27 of of IN cord-287815-alv30uk5 348 28 the the DT cord-287815-alv30uk5 348 29 Golgi Golgi NNP cord-287815-alv30uk5 348 30 apparatus apparatus NN cord-287815-alv30uk5 348 31 Vesicles Vesicles NNP cord-287815-alv30uk5 348 32 and and CC cord-287815-alv30uk5 348 33 cisternae cisternae NNP cord-287815-alv30uk5 348 34 in in IN cord-287815-alv30uk5 348 35 the the DT cord-287815-alv30uk5 348 36 trans trans NNP cord-287815-alv30uk5 348 37 Golgi Golgi NNP cord-287815-alv30uk5 348 38 apparatus apparatus NN cord-287815-alv30uk5 348 39 of of IN cord-287815-alv30uk5 348 40 human human JJ cord-287815-alv30uk5 348 41 fibroblasts fibroblast NNS cord-287815-alv30uk5 348 42 are be VBP cord-287815-alv30uk5 348 43 acidic acidic JJ cord-287815-alv30uk5 348 44 compartments compartment NNS cord-287815-alv30uk5 348 45 Reconstitution reconstitution NN cord-287815-alv30uk5 348 46 of of IN cord-287815-alv30uk5 348 47 the the DT cord-287815-alv30uk5 348 48 transport transport NN cord-287815-alv30uk5 348 49 of of IN cord-287815-alv30uk5 348 50 protein protein NN cord-287815-alv30uk5 348 51 between between IN cord-287815-alv30uk5 348 52 successive successive JJ cord-287815-alv30uk5 348 53 compartments compartment NNS cord-287815-alv30uk5 348 54 of of IN cord-287815-alv30uk5 348 55 the the DT cord-287815-alv30uk5 348 56 Golgi Golgi NNP cord-287815-alv30uk5 348 57 measured measure VBN cord-287815-alv30uk5 348 58 by by IN cord-287815-alv30uk5 348 59 the the DT cord-287815-alv30uk5 348 60 coupled coupled JJ cord-287815-alv30uk5 348 61 incorporation incorporation NN cord-287815-alv30uk5 348 62 of of IN cord-287815-alv30uk5 348 63 N N NNP cord-287815-alv30uk5 348 64 - - HYPH cord-287815-alv30uk5 348 65 acetylglucosamine acetylglucosamine NNP cord-287815-alv30uk5 348 66 An an DT cord-287815-alv30uk5 348 67 essential essential JJ cord-287815-alv30uk5 348 68 role role NN cord-287815-alv30uk5 348 69 for for IN cord-287815-alv30uk5 348 70 a a DT cord-287815-alv30uk5 348 71 phospholipid phospholipid NN cord-287815-alv30uk5 348 72 transfer transfer NN cord-287815-alv30uk5 348 73 protein protein NN cord-287815-alv30uk5 348 74 in in IN cord-287815-alv30uk5 348 75 yeast yeast NN cord-287815-alv30uk5 348 76 Golgi Golgi NNP cord-287815-alv30uk5 348 77 function function NN cord-287815-alv30uk5 348 78 Release Release NNP cord-287815-alv30uk5 348 79 of of IN cord-287815-alv30uk5 348 80 putative putative JJ cord-287815-alv30uk5 348 81 exocytic exocytic JJ cord-287815-alv30uk5 348 82 transport transport NN cord-287815-alv30uk5 348 83 vesicles vesicle NNS cord-287815-alv30uk5 348 84 from from IN cord-287815-alv30uk5 348 85 perforated perforate VBN cord-287815-alv30uk5 348 86 MDCK MDCK NNP cord-287815-alv30uk5 348 87 cells cell NNS cord-287815-alv30uk5 349 1 lmmunoelectron lmmunoelectron NNP cord-287815-alv30uk5 349 2 microscopic microscopic JJ cord-287815-alv30uk5 349 3 studies study NNS cord-287815-alv30uk5 349 4 of of IN cord-287815-alv30uk5 349 5 the the DT cord-287815-alv30uk5 349 6 intracellular intracellular JJ cord-287815-alv30uk5 349 7 transport transport NN cord-287815-alv30uk5 349 8 of of IN cord-287815-alv30uk5 349 9 the the DT cord-287815-alv30uk5 349 10 membrane membrane NN cord-287815-alv30uk5 349 11 glycoprotein glycoprotein NN cord-287815-alv30uk5 349 12 ( ( -LRB- cord-287815-alv30uk5 349 13 G g NN cord-287815-alv30uk5 349 14 ) ) -RRB- cord-287815-alv30uk5 349 15 of of IN cord-287815-alv30uk5 349 16 vesicular vesicular JJ cord-287815-alv30uk5 349 17 stomatitis stomatitis NN cord-287815-alv30uk5 349 18 virus virus NN cord-287815-alv30uk5 349 19 in in IN cord-287815-alv30uk5 349 20 infected infected JJ cord-287815-alv30uk5 349 21 Chinese chinese JJ cord-287815-alv30uk5 349 22 hamster hamster NN cord-287815-alv30uk5 349 23 ovary ovary NN cord-287815-alv30uk5 349 24 cells cell NNS cord-287815-alv30uk5 349 25 Palmitylation Palmitylation NNP cord-287815-alv30uk5 349 26 of of IN cord-287815-alv30uk5 349 27 viral viral JJ cord-287815-alv30uk5 349 28 membrane membrane NN cord-287815-alv30uk5 349 29 glycoproteins glycoprotein NNS cord-287815-alv30uk5 349 30 takes take VBZ cord-287815-alv30uk5 349 31 place place NN cord-287815-alv30uk5 349 32 after after IN cord-287815-alv30uk5 349 33 exit exit NN cord-287815-alv30uk5 349 34 from from IN cord-287815-alv30uk5 349 35 the the DT cord-287815-alv30uk5 349 36 endoplasmic endoplasmic NN cord-287815-alv30uk5 349 37 reticulum reticulum NN cord-287815-alv30uk5 350 1 The the DT cord-287815-alv30uk5 350 2 glycoprotein glycoprotein NN cord-287815-alv30uk5 350 3 that that WDT cord-287815-alv30uk5 350 4 is be VBZ cord-287815-alv30uk5 350 5 transported transport VBN cord-287815-alv30uk5 350 6 between between IN cord-287815-alv30uk5 350 7 successive successive JJ cord-287815-alv30uk5 350 8 compartments compartment NNS cord-287815-alv30uk5 350 9 of of IN cord-287815-alv30uk5 350 10 the the DT cord-287815-alv30uk5 350 11 Golgi Golgi NNP cord-287815-alv30uk5 350 12 in in IN cord-287815-alv30uk5 350 13 a a DT cord-287815-alv30uk5 350 14 cell cell NN cord-287815-alv30uk5 350 15 - - HYPH cord-287815-alv30uk5 350 16 free free JJ cord-287815-alv30uk5 350 17 system system NN cord-287815-alv30uk5 350 18 resides reside VBZ cord-287815-alv30uk5 350 19 in in IN cord-287815-alv30uk5 350 20 stacks stack NNS cord-287815-alv30uk5 350 21 of of IN cord-287815-alv30uk5 350 22 cisternae cisternae NN cord-287815-alv30uk5 351 1 A a DT cord-287815-alv30uk5 351 2 single single JJ cord-287815-alv30uk5 351 3 amino amino NN cord-287815-alv30uk5 351 4 acid acid NN cord-287815-alv30uk5 351 5 change change NN cord-287815-alv30uk5 351 6 rn rn NN cord-287815-alv30uk5 352 1 the the DT cord-287815-alv30uk5 352 2 cytoplasmic cytoplasmic JJ cord-287815-alv30uk5 352 3 domain domain NN cord-287815-alv30uk5 352 4 alters alter VBZ cord-287815-alv30uk5 352 5 the the DT cord-287815-alv30uk5 352 6 polarized polarized JJ cord-287815-alv30uk5 352 7 delivery delivery NN cord-287815-alv30uk5 352 8 of of IN cord-287815-alv30uk5 352 9 influenza influenza NN cord-287815-alv30uk5 352 10 virus virus NN cord-287815-alv30uk5 352 11 hemagglutinin hemagglutinin VBD cord-287815-alv30uk5 352 12 A a DT cord-287815-alv30uk5 352 13 cell cell NN cord-287815-alv30uk5 352 14 free free JJ cord-287815-alv30uk5 352 15 system system NN cord-287815-alv30uk5 352 16 to to TO cord-287815-alv30uk5 352 17 study study VB cord-287815-alv30uk5 352 18 reassembly reassembly RB cord-287815-alv30uk5 352 19 of of IN cord-287815-alv30uk5 352 20 the the DT cord-287815-alv30uk5 352 21 nuclear nuclear JJ cord-287815-alv30uk5 352 22 envelope envelope NN cord-287815-alv30uk5 352 23 at at IN cord-287815-alv30uk5 352 24 the the DT cord-287815-alv30uk5 352 25 end end NN cord-287815-alv30uk5 352 26 of of IN cord-287815-alv30uk5 352 27 mitosis mitosis NN cord-287815-alv30uk5 352 28 Localization localization NN cord-287815-alv30uk5 352 29 of of IN cord-287815-alv30uk5 352 30 low low JJ cord-287815-alv30uk5 352 31 molecular molecular JJ cord-287815-alv30uk5 352 32 weight weight NN cord-287815-alv30uk5 352 33 GTP GTP NNP cord-287815-alv30uk5 352 34 binding bind VBG cord-287815-alv30uk5 352 35 proteins protein NNS cord-287815-alv30uk5 352 36 to to IN cord-287815-alv30uk5 352 37 exocytic exocytic JJ cord-287815-alv30uk5 352 38 and and CC cord-287815-alv30uk5 352 39 endocytic endocytic JJ cord-287815-alv30uk5 352 40 compartments compartment NNS cord-287815-alv30uk5 352 41 Compartmentation Compartmentation NNP cord-287815-alv30uk5 352 42 of of IN cord-287815-alv30uk5 352 43 the the DT cord-287815-alv30uk5 352 44 Golgi Golgi NNP cord-287815-alv30uk5 352 45 complex complex NN cord-287815-alv30uk5 352 46 : : : cord-287815-alv30uk5 352 47 brefeldin brefeldin NNP cord-287815-alv30uk5 352 48 - - HYPH cord-287815-alv30uk5 352 49 A A NNP cord-287815-alv30uk5 352 50 distinguishes distinguish VBZ cord-287815-alv30uk5 352 51 bans ban VBZ cord-287815-alv30uk5 352 52 - - : cord-287815-alv30uk5 352 53 Golgi Golgi NNP cord-287815-alv30uk5 352 54 cisternae cisternae NN cord-287815-alv30uk5 352 55 from from IN cord-287815-alv30uk5 352 56 the the DT cord-287815-alv30uk5 352 57 trans trans NNP cord-287815-alv30uk5 352 58 - - NNP cord-287815-alv30uk5 352 59 Golgi Golgi NNP cord-287815-alv30uk5 352 60 network network NN cord-287815-alv30uk5 352 61 SNAPS snap NNS cord-287815-alv30uk5 352 62 , , , cord-287815-alv30uk5 352 63 a a DT cord-287815-alv30uk5 352 64 family family NN cord-287815-alv30uk5 352 65 of of IN cord-287815-alv30uk5 352 66 NSF NSF NNP cord-287815-alv30uk5 352 67 attachment attachment NN cord-287815-alv30uk5 352 68 proteins protein NNS cord-287815-alv30uk5 352 69 involved involve VBN cord-287815-alv30uk5 352 70 in in IN cord-287815-alv30uk5 352 71 intracellular intracellular JJ cord-287815-alv30uk5 352 72 membrane membrane NN cord-287815-alv30uk5 352 73 fusion fusion NN cord-287815-alv30uk5 352 74 in in IN cord-287815-alv30uk5 352 75 animals animal NNS cord-287815-alv30uk5 352 76 and and CC cord-287815-alv30uk5 352 77 yeast yeast NN cord-287815-alv30uk5 352 78 Mutations Mutations NNPS cord-287815-alv30uk5 352 79 in in IN cord-287815-alv30uk5 352 80 the the DT cord-287815-alv30uk5 352 81 CDP CDP NNP cord-287815-alv30uk5 352 82 - - HYPH cord-287815-alv30uk5 352 83 choline choline NN cord-287815-alv30uk5 352 84 pathway pathway NN cord-287815-alv30uk5 352 85 for for IN cord-287815-alv30uk5 352 86 phospholipid phospholipid NN cord-287815-alv30uk5 352 87 biosynthesis biosynthesis NN cord-287815-alv30uk5 352 88 bypass bypass VBP cord-287815-alv30uk5 352 89 the the DT cord-287815-alv30uk5 352 90 requirement requirement NN cord-287815-alv30uk5 352 91 for for IN cord-287815-alv30uk5 352 92 an an DT cord-287815-alv30uk5 352 93 essential essential JJ cord-287815-alv30uk5 352 94 phospholipid phospholipid NN cord-287815-alv30uk5 352 95 transfer transfer NN cord-287815-alv30uk5 352 96 protein protein NN cord-287815-alv30uk5 352 97 Conversion conversion NN cord-287815-alv30uk5 352 98 of of IN cord-287815-alv30uk5 352 99 a a DT cord-287815-alv30uk5 352 100 Golgi Golgi NNP cord-287815-alv30uk5 352 101 apparatus apparatus NN cord-287815-alv30uk5 352 102 sialyltransferase sialyltransferase NN cord-287815-alv30uk5 352 103 to to IN cord-287815-alv30uk5 352 104 a a DT cord-287815-alv30uk5 352 105 secretory secretory JJ cord-287815-alv30uk5 352 106 protein protein NN cord-287815-alv30uk5 352 107 by by IN cord-287815-alv30uk5 352 108 replacement replacement NN cord-287815-alv30uk5 352 109 of of IN cord-287815-alv30uk5 352 110 the the DT cord-287815-alv30uk5 352 111 NH?-terminal NH?-terminal NNP cord-287815-alv30uk5 352 112 signal signal NNP cord-287815-alv30uk5 352 113 anchor anchor NN cord-287815-alv30uk5 352 114 with with IN cord-287815-alv30uk5 352 115 a a DT cord-287815-alv30uk5 352 116 signal signal NN cord-287815-alv30uk5 352 117 peptide peptide NN cord-287815-alv30uk5 352 118 Tubulovesicular Tubulovesicular NNP cord-287815-alv30uk5 352 119 processes process NNS cord-287815-alv30uk5 352 120 emerge emerge VBP cord-287815-alv30uk5 352 121 from from IN cord-287815-alv30uk5 352 122 tram tram NN cord-287815-alv30uk5 352 123 - - HYPH cord-287815-alv30uk5 352 124 Golgi Golgi NNP cord-287815-alv30uk5 352 125 cisternae cisternae NNP cord-287815-alv30uk5 352 126 , , , cord-287815-alv30uk5 352 127 extend extend VBP cord-287815-alv30uk5 352 128 along along IN cord-287815-alv30uk5 352 129 microtubules microtubule NNS cord-287815-alv30uk5 352 130 , , , cord-287815-alv30uk5 352 131 and and CC cord-287815-alv30uk5 352 132 interlink interlink VBP cord-287815-alv30uk5 352 133 adjacent adjacent JJ cord-287815-alv30uk5 352 134 frans frans NNP cord-287815-alv30uk5 352 135 - - HYPH cord-287815-alv30uk5 352 136 Golgi Golgi NNP cord-287815-alv30uk5 352 137 elements element NNS cord-287815-alv30uk5 352 138 into into IN cord-287815-alv30uk5 352 139 a a DT cord-287815-alv30uk5 352 140 reticulum reticulum NN cord-287815-alv30uk5 353 1 The the DT cord-287815-alv30uk5 353 2 distribution distribution NN cord-287815-alv30uk5 353 3 of of IN cord-287815-alv30uk5 353 4 repeating repeat VBG cord-287815-alv30uk5 353 5 [ [ -LRB- cord-287815-alv30uk5 353 6 Gal81,4GlcNAchl,3 Gal81,4GlcNAchl,3 NNP cord-287815-alv30uk5 353 7 ] ] -RRB- cord-287815-alv30uk5 353 8 sequences sequence NNS cord-287815-alv30uk5 353 9 in in IN cord-287815-alv30uk5 353 10 asparatine asparatine NN cord-287815-alv30uk5 353 11 - - HYPH cord-287815-alv30uk5 353 12 linked link VBN cord-287815-alv30uk5 353 13 oligosaccharides oligosaccharide NNS cord-287815-alv30uk5 353 14 of of IN cord-287815-alv30uk5 353 15 the the DT cord-287815-alv30uk5 353 16 mouse mouse NN cord-287815-alv30uk5 353 17 lymphomacell lymphomacell NNP cord-287815-alv30uk5 353 18 lines line NNS cord-287815-alv30uk5 354 1 BW5147and BW5147and NNP cord-287815-alv30uk5 354 2 PHAk2.1 PHAk2.1 NNP cord-287815-alv30uk5 355 1 The the DT cord-287815-alv30uk5 355 2 microtubule microtubule NN cord-287815-alv30uk5 355 3 - - HYPH cord-287815-alv30uk5 355 4 dependent dependent JJ cord-287815-alv30uk5 355 5 formation formation NN cord-287815-alv30uk5 355 6 of of IN cord-287815-alv30uk5 355 7 a a DT cord-287815-alv30uk5 355 8 tubulovesicular tubulovesicular JJ cord-287815-alv30uk5 355 9 network network NN cord-287815-alv30uk5 355 10 with with IN cord-287815-alv30uk5 355 11 characteristics characteristic NNS cord-287815-alv30uk5 355 12 of of IN cord-287815-alv30uk5 355 13 the the DT cord-287815-alv30uk5 355 14 ER ER NNP cord-287815-alv30uk5 355 15 from from IN cord-287815-alv30uk5 355 16 cultured cultured JJ cord-287815-alv30uk5 355 17 cell cell NN cord-287815-alv30uk5 355 18 extracts extract NNS cord-287815-alv30uk5 355 19 Recycling Recycling NNP cord-287815-alv30uk5 355 20 of of IN cord-287815-alv30uk5 355 21 proteins protein NNS cord-287815-alv30uk5 355 22 from from IN cord-287815-alv30uk5 355 23 the the DT cord-287815-alv30uk5 355 24 Golgi Golgi NNP cord-287815-alv30uk5 355 25 compartment compartment NN cord-287815-alv30uk5 355 26 to to IN cord-287815-alv30uk5 355 27 the the DT cord-287815-alv30uk5 355 28 ER ER NNP cord-287815-alv30uk5 355 29 in in IN cord-287815-alv30uk5 355 30 yeast yeast NN cord-287815-alv30uk5 355 31 Translocation translocation NN cord-287815-alv30uk5 355 32 across across IN cord-287815-alv30uk5 355 33 Golgi Golgi NNP cord-287815-alv30uk5 355 34 vesicle vesicle NN cord-287815-alv30uk5 355 35 membranes membrane NNS cord-287815-alv30uk5 355 36 : : : cord-287815-alv30uk5 356 1 aCH0 aCH0 NNP cord-287815-alv30uk5 356 2 glycosylation glycosylation NN cord-287815-alv30uk5 356 3 mutant mutant NN cord-287815-alv30uk5 356 4 deficient deficient JJ cord-287815-alv30uk5 356 5 in in IN cord-287815-alv30uk5 356 6 CMP cmp NN cord-287815-alv30uk5 356 7 - - HYPH cord-287815-alv30uk5 356 8 sialic sialic NN cord-287815-alv30uk5 356 9 acid acid NN cord-287815-alv30uk5 356 10 transport transport NN cord-287815-alv30uk5 356 11 Guanine guanine NN cord-287815-alv30uk5 356 12 nucleotides nucleotide NNS cord-287815-alv30uk5 356 13 modulate modulate VBP cord-287815-alv30uk5 356 14 the the DT cord-287815-alv30uk5 356 15 effects effect NNS cord-287815-alv30uk5 356 16 of of IN cord-287815-alv30uk5 356 17 brefeldin brefeldin NNS cord-287815-alv30uk5 356 18 A A NNP cord-287815-alv30uk5 356 19 In in IN cord-287815-alv30uk5 356 20 semipermeable semipermeable JJ cord-287815-alv30uk5 356 21 cells cell NNS cord-287815-alv30uk5 356 22 : : : cord-287815-alv30uk5 356 23 regulation regulation NN cord-287815-alv30uk5 356 24 of of IN cord-287815-alv30uk5 356 25 the the DT cord-287815-alv30uk5 356 26 association association NN cord-287815-alv30uk5 356 27 of of IN cord-287815-alv30uk5 356 28 a a DT cord-287815-alv30uk5 356 29 11 11 CD cord-287815-alv30uk5 356 30 0-kD 0-kd CD cord-287815-alv30uk5 356 31 peripheral peripheral JJ cord-287815-alv30uk5 356 32 membrane membrane NN cord-287815-alv30uk5 356 33 protein protein NN cord-287815-alv30uk5 356 34 with with IN cord-287815-alv30uk5 356 35 the the DT cord-287815-alv30uk5 356 36 Golgi Golgi NNP cord-287815-alv30uk5 356 37 apparatus apparatus NN cord-287815-alv30uk5 356 38 Binding Binding NNP cord-287815-alv30uk5 356 39 of of IN cord-287815-alv30uk5 356 40 ARF ARF NNP cord-287815-alv30uk5 356 41 and and CC cord-287815-alv30uk5 356 42 5COP 5COP NNP cord-287815-alv30uk5 356 43 to to IN cord-287815-alv30uk5 356 44 Golgi Golgi NNP cord-287815-alv30uk5 356 45 membranes membrane NNS cord-287815-alv30uk5 356 46 : : : cord-287815-alv30uk5 356 47 possible possible JJ cord-287815-alv30uk5 356 48 regulation regulation NN cord-287815-alv30uk5 356 49 by by IN cord-287815-alv30uk5 356 50 a a DT cord-287815-alv30uk5 356 51 trimeric trimeric JJ cord-287815-alv30uk5 356 52 G g NN cord-287815-alv30uk5 356 53 protein protein NN cord-287815-alv30uk5 356 54 Polarized polarized JJ cord-287815-alv30uk5 356 55 sorting sorting NN cord-287815-alv30uk5 356 56 of of IN cord-287815-alv30uk5 356 57 viral viral JJ cord-287815-alv30uk5 356 58 glycoproteins glycoprotein NNS cord-287815-alv30uk5 356 59 to to IN cord-287815-alv30uk5 356 60 the the DT cord-287815-alv30uk5 356 61 axon axon NN cord-287815-alv30uk5 356 62 and and CC cord-287815-alv30uk5 356 63 dendrites dendrite NNS cord-287815-alv30uk5 356 64 of of IN cord-287815-alv30uk5 356 65 hippocampal hippocampal JJ cord-287815-alv30uk5 356 66 neurons neuron NNS cord-287815-alv30uk5 356 67 in in IN cord-287815-alv30uk5 356 68 culture culture NN cord-287815-alv30uk5 356 69 Involvement Involvement NNP cord-287815-alv30uk5 356 70 of of IN cord-287815-alv30uk5 356 71 5.COP 5.cop CD cord-287815-alv30uk5 356 72 rn rn NN cord-287815-alv30uk5 356 73 membrane membrane NN cord-287815-alv30uk5 356 74 traffic traffic NN cord-287815-alv30uk5 356 75 through through IN cord-287815-alv30uk5 356 76 the the DT cord-287815-alv30uk5 356 77 Golgi Golgi NNP cord-287815-alv30uk5 356 78 complex complex NN cord-287815-alv30uk5 356 79 110 110 CD cord-287815-alv30uk5 356 80 kd kd NNP cord-287815-alv30uk5 356 81 protein protein NN cord-287815-alv30uk5 356 82 associated associate VBN cord-287815-alv30uk5 356 83 with with IN cord-287815-alv30uk5 356 84 non non JJ cord-287815-alv30uk5 356 85 - - JJ cord-287815-alv30uk5 356 86 clathrin clathrin JJ cord-287815-alv30uk5 356 87 - - HYPH cord-287815-alv30uk5 356 88 coated coat VBN cord-287815-alv30uk5 356 89 vesicles vesicle NNS cord-287815-alv30uk5 356 90 and and CC cord-287815-alv30uk5 356 91 the the DT cord-287815-alv30uk5 356 92 Golgi Golgi NNP cord-287815-alv30uk5 356 93 complex complex NN cord-287815-alv30uk5 356 94 , , , cord-287815-alv30uk5 356 95 shows show VBZ cord-287815-alv30uk5 356 96 homology homology NN cord-287815-alv30uk5 356 97 to to IN cord-287815-alv30uk5 356 98 5.adaptin 5.adaptin CD cord-287815-alv30uk5 356 99 Intracellular Intracellular NNP cord-287815-alv30uk5 356 100 movement movement NN cord-287815-alv30uk5 356 101 of of IN cord-287815-alv30uk5 356 102 two two CD cord-287815-alv30uk5 356 103 mannose mannose JJ cord-287815-alv30uk5 356 104 8-phosphate 8-phosphate CD cord-287815-alv30uk5 356 105 receptors receptor NNS cord-287815-alv30uk5 356 106 : : : cord-287815-alv30uk5 357 1 return return VB cord-287815-alv30uk5 357 2 to to IN cord-287815-alv30uk5 357 3 the the DT cord-287815-alv30uk5 357 4 Golgi Golgi NNP cord-287815-alv30uk5 357 5 apparatus apparatus NN cord-287815-alv30uk5 357 6 Compartmentation compartmentation NN cord-287815-alv30uk5 357 7 of of IN cord-287815-alv30uk5 357 8 asparagine asparagine NN cord-287815-alv30uk5 357 9 - - HYPH cord-287815-alv30uk5 357 10 linked link VBN cord-287815-alv30uk5 357 11 oligosaccharide oligosaccharide NN cord-287815-alv30uk5 357 12 processing processing NN cord-287815-alv30uk5 357 13 in in IN cord-287815-alv30uk5 357 14 the the DT cord-287815-alv30uk5 357 15 Golgi Golgi NNP cord-287815-alv30uk5 357 16 apparatus apparatus NN cord-287815-alv30uk5 357 17 Attachment Attachment NNP cord-287815-alv30uk5 357 18 of of IN cord-287815-alv30uk5 357 19 terminal terminal JJ cord-287815-alv30uk5 357 20 N n CD cord-287815-alv30uk5 357 21 - - HYPH cord-287815-alv30uk5 357 22 acetylglucosamine acetylglucosamine NNP cord-287815-alv30uk5 357 23 to to IN cord-287815-alv30uk5 357 24 asparagine asparagine NN cord-287815-alv30uk5 357 25 - - HYPH cord-287815-alv30uk5 357 26 linked link VBN cord-287815-alv30uk5 357 27 oligosaccharides oligosaccharide NNS cord-287815-alv30uk5 357 28 occurs occur VBZ cord-287815-alv30uk5 357 29 in in IN cord-287815-alv30uk5 357 30 central central JJ cord-287815-alv30uk5 357 31 cisternae cisternae NN cord-287815-alv30uk5 357 32 of of IN cord-287815-alv30uk5 357 33 the the DT cord-287815-alv30uk5 357 34 Golgi Golgi NNP cord-287815-alv30uk5 357 35 stack stack NN cord-287815-alv30uk5 357 36 The the DT cord-287815-alv30uk5 357 37 Golgl Golgl NNP cord-287815-alv30uk5 357 38 apparatus apparatus NN cord-287815-alv30uk5 357 39 ( ( -LRB- cord-287815-alv30uk5 357 40 complex)-(1954 complex)-(1954 XX cord-287815-alv30uk5 357 41 - - HYPH cord-287815-alv30uk5 357 42 1981)from 1981)from CD cord-287815-alv30uk5 357 43 artifact artifact NN cord-287815-alv30uk5 357 44 to to IN cord-287815-alv30uk5 357 45 center center NN cord-287815-alv30uk5 357 46 stage stage NN cord-287815-alv30uk5 358 1 Transrent Transrent NNP cord-287815-alv30uk5 358 2 activity activity NN cord-287815-alv30uk5 358 3 of of IN cord-287815-alv30uk5 358 4 Golgl Golgl NNP cord-287815-alv30uk5 358 5 - - HYPH cord-287815-alv30uk5 358 6 like like JJ cord-287815-alv30uk5 358 7 membranes membrane NNS cord-287815-alv30uk5 358 8 as as IN cord-287815-alv30uk5 358 9 donors donor NNS cord-287815-alv30uk5 358 10 of of IN cord-287815-alv30uk5 358 11 vesicular vesicular JJ cord-287815-alv30uk5 358 12 stomatitis stomatitis NN cord-287815-alv30uk5 358 13 viral viral JJ cord-287815-alv30uk5 358 14 glycoprotein glycoprotein NN cord-287815-alv30uk5 358 15 in in IN cord-287815-alv30uk5 358 16 vitro vitro FW cord-287815-alv30uk5 358 17 Small small JJ cord-287815-alv30uk5 358 18 GTP GTP NNP cord-287815-alv30uk5 358 19 - - HYPH cord-287815-alv30uk5 358 20 binding bind VBG cord-287815-alv30uk5 358 21 protem protem NN cord-287815-alv30uk5 358 22 associated associate VBN cord-287815-alv30uk5 358 23 with with IN cord-287815-alv30uk5 358 24 Golgi Golgi NNP cord-287815-alv30uk5 358 25 cisternae cisternae JJ cord-287815-alv30uk5 358 26 Evidence evidence NN cord-287815-alv30uk5 358 27 for for IN cord-287815-alv30uk5 358 28 extensive extensive JJ cord-287815-alv30uk5 358 29 subcellular subcellular JJ cord-287815-alv30uk5 358 30 organization organization NN cord-287815-alv30uk5 358 31 of of IN cord-287815-alv30uk5 358 32 asparagine asparagine NN cord-287815-alv30uk5 358 33 - - HYPH cord-287815-alv30uk5 358 34 linked link VBN cord-287815-alv30uk5 358 35 oligosaccharide oligosaccharide NN cord-287815-alv30uk5 358 36 processing processing NN cord-287815-alv30uk5 358 37 and and CC cord-287815-alv30uk5 358 38 lysosomal lysosomal JJ cord-287815-alv30uk5 358 39 enzyme enzyme NN cord-287815-alv30uk5 359 1 phosphorylation phosphorylation NN cord-287815-alv30uk5 359 2 Compartmental Compartmental NNP cord-287815-alv30uk5 359 3 organization organization NN cord-287815-alv30uk5 359 4 of of IN cord-287815-alv30uk5 359 5 Golgi Golgi NNP cord-287815-alv30uk5 359 6 - - HYPH cord-287815-alv30uk5 359 7 specific specific JJ cord-287815-alv30uk5 359 8 protein protein NN cord-287815-alv30uk5 359 9 modification modification NN cord-287815-alv30uk5 359 10 and and CC cord-287815-alv30uk5 359 11 vacuolar vacuolar NNP cord-287815-alv30uk5 359 12 protein protein NN cord-287815-alv30uk5 359 13 sorting sort VBG cord-287815-alv30uk5 359 14 events event NNS cord-287815-alv30uk5 359 15 defined define VBN cord-287815-alv30uk5 359 16 in in IN cord-287815-alv30uk5 359 17 a a DT cord-287815-alv30uk5 359 18 yeast yeast NN cord-287815-alv30uk5 359 19 secl8 secl8 NN cord-287815-alv30uk5 359 20 ( ( -LRB- cord-287815-alv30uk5 359 21 NSF NSF NNP cord-287815-alv30uk5 359 22 ) ) -RRB- cord-287815-alv30uk5 359 23 mutant mutant NN cord-287815-alv30uk5 360 1 The the DT cord-287815-alv30uk5 360 2 trans trans NNP cord-287815-alv30uk5 360 3 Golgi Golgi NNP cord-287815-alv30uk5 360 4 network network NN cord-287815-alv30uk5 360 5 : : : cord-287815-alv30uk5 360 6 sorting sort VBG cord-287815-alv30uk5 360 7 at at IN cord-287815-alv30uk5 360 8 the the DT cord-287815-alv30uk5 360 9 exit exit NN cord-287815-alv30uk5 360 10 site site NN cord-287815-alv30uk5 360 11 of of IN cord-287815-alv30uk5 360 12 the the DT cord-287815-alv30uk5 360 13 Golgr Golgr NNP cord-287815-alv30uk5 360 14 complex complex JJ cord-287815-alv30uk5 360 15 Density density NN cord-287815-alv30uk5 360 16 of of IN cord-287815-alv30uk5 360 17 newly newly RB cord-287815-alv30uk5 360 18 synthesized synthesize VBN cord-287815-alv30uk5 360 19 plasma plasma NN cord-287815-alv30uk5 360 20 membrane membrane NN cord-287815-alv30uk5 360 21 proteins protein NNS cord-287815-alv30uk5 360 22 in in IN cord-287815-alv30uk5 360 23 intracellular intracellular JJ cord-287815-alv30uk5 360 24 membranes membrane NNS cord-287815-alv30uk5 360 25 . . . cord-287815-alv30uk5 361 1 I. I. NNP cord-287815-alv30uk5 361 2 Stereological Stereological NNP cord-287815-alv30uk5 361 3 studies study NNS cord-287815-alv30uk5 361 4 Exit exit NN cord-287815-alv30uk5 361 5 of of IN cord-287815-alv30uk5 361 6 newly newly RB cord-287815-alv30uk5 361 7 synthesized synthesize VBN cord-287815-alv30uk5 361 8 membrane membrane NN cord-287815-alv30uk5 361 9 proteins protein NNS cord-287815-alv30uk5 361 10 from from IN cord-287815-alv30uk5 361 11 the the DT cord-287815-alv30uk5 361 12 trans trans NNP cord-287815-alv30uk5 361 13 cisterna cisterna NNP cord-287815-alv30uk5 361 14 of of IN cord-287815-alv30uk5 361 15 the the DT cord-287815-alv30uk5 361 16 Golgi Golgi NNP cord-287815-alv30uk5 361 17 complex complex NN cord-287815-alv30uk5 361 18 to to IN cord-287815-alv30uk5 361 19 the the DT cord-287815-alv30uk5 361 20 plasma plasma NN cord-287815-alv30uk5 361 21 membrane membrane NN cord-287815-alv30uk5 362 1 The the DT cord-287815-alv30uk5 362 2 dynamic dynamic JJ cord-287815-alv30uk5 362 3 nature nature NN cord-287815-alv30uk5 362 4 of of IN cord-287815-alv30uk5 362 5 the the DT cord-287815-alv30uk5 362 6 Golgi Golgi NNP cord-287815-alv30uk5 362 7 complex complex JJ cord-287815-alv30uk5 362 8 Isolation isolation NN cord-287815-alv30uk5 362 9 of of IN cord-287815-alv30uk5 362 10 a a DT cord-287815-alv30uk5 362 11 functional functional JJ cord-287815-alv30uk5 362 12 vesicular vesicular JJ cord-287815-alv30uk5 362 13 intermediate intermediate NN cord-287815-alv30uk5 362 14 that that WDT cord-287815-alv30uk5 362 15 mediates mediate VBZ cord-287815-alv30uk5 362 16 ER ER NNP cord-287815-alv30uk5 362 17 to to IN cord-287815-alv30uk5 362 18 Golgi Golgi NNP cord-287815-alv30uk5 362 19 transport transport NN cord-287815-alv30uk5 362 20 in in IN cord-287815-alv30uk5 362 21 yeast yeast NN cord-287815-alv30uk5 362 22 Membrane membrane NN cord-287815-alv30uk5 362 23 traffic traffic NN cord-287815-alv30uk5 362 24 in in IN cord-287815-alv30uk5 362 25 endocytosis endocytosis NN cord-287815-alv30uk5 362 26 : : : cord-287815-alv30uk5 363 1 insights insight NNS cord-287815-alv30uk5 363 2 from from IN cord-287815-alv30uk5 363 3 cell cell NN cord-287815-alv30uk5 363 4 - - HYPH cord-287815-alv30uk5 363 5 free free JJ cord-287815-alv30uk5 363 6 assays assay NNS cord-287815-alv30uk5 363 7 Reconstitution reconstitution NN cord-287815-alv30uk5 363 8 of of IN cord-287815-alv30uk5 363 9 steps step NNS cord-287815-alv30uk5 363 10 in in IN cord-287815-alv30uk5 363 11 the the DT cord-287815-alv30uk5 363 12 constitutive constitutive JJ cord-287815-alv30uk5 363 13 secretorypathwayin secretorypathwayin NNP cord-287815-alv30uk5 363 14 permeabilized permeabilized NNP cord-287815-alv30uk5 363 15 cells cell NNS cord-287815-alv30uk5 363 16 Three three CD cord-287815-alv30uk5 363 17 - - HYPH cord-287815-alv30uk5 363 18 dimensional dimensional JJ cord-287815-alv30uk5 363 19 architecture architecture NN cord-287815-alv30uk5 363 20 of of IN cord-287815-alv30uk5 363 21 the the DT cord-287815-alv30uk5 363 22 cortical cortical JJ cord-287815-alv30uk5 363 23 region region NN cord-287815-alv30uk5 363 24 of of IN cord-287815-alv30uk5 363 25 the the DT cord-287815-alv30uk5 363 26 Golgi Golgi NNP cord-287815-alv30uk5 363 27 - - HYPH cord-287815-alv30uk5 363 28 apparatus apparatus NN cord-287815-alv30uk5 363 29 in in IN cord-287815-alv30uk5 363 30 rat rat NN cord-287815-alv30uk5 363 31 spermatids spermatid NNS cord-287815-alv30uk5 363 32 Reclustering Reclustering NNP cord-287815-alv30uk5 363 33 of of IN cord-287815-alv30uk5 363 34 scattered scatter VBN cord-287815-alv30uk5 363 35 Golgi Golgi NNP cord-287815-alv30uk5 363 36 elementsoccurs elementsoccur NNS cord-287815-alv30uk5 363 37 along along IN cord-287815-alv30uk5 363 38 microtubules microtubule NNS cord-287815-alv30uk5 363 39 Movement Movement NNP cord-287815-alv30uk5 363 40 of of IN cord-287815-alv30uk5 363 41 internalized internalize VBN cord-287815-alv30uk5 363 42 ligand ligand NN cord-287815-alv30uk5 363 43 - - HYPH cord-287815-alv30uk5 363 44 receptor receptor NN cord-287815-alv30uk5 363 45 complexes complex NNS cord-287815-alv30uk5 363 46 along along IN cord-287815-alv30uk5 363 47 a a DT cord-287815-alv30uk5 363 48 continuous continuous JJ cord-287815-alv30uk5 363 49 endosomal endosomal NN cord-287815-alv30uk5 363 50 reticulum reticulum NN cord-287815-alv30uk5 363 51 Derived derive VBD cord-287815-alv30uk5 363 52 protein protein NN cord-287815-alv30uk5 363 53 sequence sequence NN cord-287815-alv30uk5 363 54 , , , cord-287815-alv30uk5 363 55 oligosaccharides oligosaccharide NNS cord-287815-alv30uk5 363 56 , , , cord-287815-alv30uk5 363 57 and and CC cord-287815-alv30uk5 363 58 membrane membrane NN cord-287815-alv30uk5 363 59 insertion insertion NN cord-287815-alv30uk5 363 60 of of IN cord-287815-alv30uk5 363 61 the the DT cord-287815-alv30uk5 363 62 120 120 CD cord-287815-alv30uk5 363 63 kD kd VBP cord-287815-alv30uk5 363 64 lysosomal lysosomal JJ cord-287815-alv30uk5 363 65 membrane membrane NN cord-287815-alv30uk5 363 66 protein protein NN cord-287815-alv30uk5 363 67 ( ( -LRB- cord-287815-alv30uk5 363 68 Igpl20 Igpl20 NNP cord-287815-alv30uk5 363 69 ) ) -RRB- cord-287815-alv30uk5 364 1 : : : cord-287815-alv30uk5 364 2 identification identification NN cord-287815-alv30uk5 364 3 of of IN cord-287815-alv30uk5 364 4 a a DT cord-287815-alv30uk5 364 5 highly highly RB cord-287815-alv30uk5 364 6 conserved conserve VBN cord-287815-alv30uk5 364 7 family family NN cord-287815-alv30uk5 364 8 of of IN cord-287815-alv30uk5 364 9 lysosomal lysosomal JJ cord-287815-alv30uk5 364 10 membrane membrane NN cord-287815-alv30uk5 364 11 glycoproteins glycoprotein VBZ cord-287815-alv30uk5 364 12 A a DT cord-287815-alv30uk5 364 13 recycling recycling NN cord-287815-alv30uk5 364 14 pathway pathway NN cord-287815-alv30uk5 364 15 between between IN cord-287815-alv30uk5 364 16 the the DT cord-287815-alv30uk5 364 17 endoplasmic endoplasmic NN cord-287815-alv30uk5 364 18 reticulum reticulum NN cord-287815-alv30uk5 364 19 and and CC cord-287815-alv30uk5 364 20 the the DT cord-287815-alv30uk5 364 21 Golgi Golgi NNP cord-287815-alv30uk5 364 22 apparatus apparatus NN cord-287815-alv30uk5 364 23 for for IN cord-287815-alv30uk5 364 24 retention retention NN cord-287815-alv30uk5 364 25 of of IN cord-287815-alv30uk5 364 26 unassembled unassembled JJ cord-287815-alv30uk5 364 27 MHC MHC NNP cord-287815-alv30uk5 364 28 class class NN cord-287815-alv30uk5 365 1 I -PRON- PRP cord-287815-alv30uk5 365 2 molecules molecule VBZ cord-287815-alv30uk5 365 3 Basolateral Basolateral NNP cord-287815-alv30uk5 365 4 sorting sort VBG cord-287815-alv30uk5 365 5 in in IN cord-287815-alv30uk5 365 6 MDCKcells MDCKcells NNP cord-287815-alv30uk5 365 7 requiresadistinct requiresadistinct NNP cord-287815-alv30uk5 365 8 cytoplasmicdomain cytoplasmicdomain NNP cord-287815-alv30uk5 365 9 determinant determinant NN cord-287815-alv30uk5 365 10 Selective selective JJ cord-287815-alv30uk5 365 11 inhibition inhibition NN cord-287815-alv30uk5 365 12 of of IN cord-287815-alv30uk5 365 13 transcytosis transcytosis NNP cord-287815-alv30uk5 365 14 by by IN cord-287815-alv30uk5 365 15 brefeldin brefeldin NNP cord-287815-alv30uk5 365 16 A A NNP cord-287815-alv30uk5 365 17 in in IN cord-287815-alv30uk5 365 18 MDCK MDCK NNP cord-287815-alv30uk5 365 19 cells cell NNS cord-287815-alv30uk5 365 20 Protein Protein NNP cord-287815-alv30uk5 365 21 sulfation sulfation NN cord-287815-alv30uk5 365 22 on on IN cord-287815-alv30uk5 365 23 tyrosine tyrosine NN cord-287815-alv30uk5 365 24 Biosynthetic biosynthetic JJ cord-287815-alv30uk5 365 25 protein protein NN cord-287815-alv30uk5 365 26 transport transport NN cord-287815-alv30uk5 365 27 in in IN cord-287815-alv30uk5 365 28 the the DT cord-287815-alv30uk5 365 29 secretory secretory JJ cord-287815-alv30uk5 365 30 pathway pathway NN cord-287815-alv30uk5 365 31 Localization Localization NNP cord-287815-alv30uk5 365 32 of of IN cord-287815-alv30uk5 365 33 mitochondria mitochondrion NNS cord-287815-alv30uk5 365 34 in in IN cord-287815-alv30uk5 365 35 living live VBG cord-287815-alv30uk5 365 36 cells cell NNS cord-287815-alv30uk5 365 37 with with IN cord-287815-alv30uk5 365 38 rhodamine rhodamine NN cord-287815-alv30uk5 365 39 123 123 CD cord-287815-alv30uk5 365 40 Fluoride fluoride NN cord-287815-alv30uk5 366 1 is be VBZ cord-287815-alv30uk5 366 2 not not RB cord-287815-alv30uk5 366 3 an an DT cord-287815-alv30uk5 366 4 activator activator NN cord-287815-alv30uk5 366 5 of of IN cord-287815-alv30uk5 366 6 the the DT cord-287815-alv30uk5 366 7 smaller small JJR cord-287815-alv30uk5 366 8 ( ( -LRB- cord-287815-alv30uk5 366 9 20 20 CD cord-287815-alv30uk5 366 10 - - SYM cord-287815-alv30uk5 366 11 25 25 CD cord-287815-alv30uk5 366 12 kDa kDa NNS cord-287815-alv30uk5 366 13 ) ) -RRB- cord-287815-alv30uk5 366 14 GTP GTP NNP cord-287815-alv30uk5 366 15 - - HYPH cord-287815-alv30uk5 366 16 binding bind VBG cord-287815-alv30uk5 366 17 proteins protein NNS cord-287815-alv30uk5 367 1 The the DT cord-287815-alv30uk5 367 2 rate rate NN cord-287815-alv30uk5 367 3 of of IN cord-287815-alv30uk5 367 4 bulk bulk JJ cord-287815-alv30uk5 367 5 flow flow NN cord-287815-alv30uk5 367 6 from from IN cord-287815-alv30uk5 367 7 the the DT cord-287815-alv30uk5 367 8 Golgi Golgi NNP cord-287815-alv30uk5 367 9 to to IN cord-287815-alv30uk5 367 10 the the DT cord-287815-alv30uk5 367 11 plasma plasma NN cord-287815-alv30uk5 367 12 membrane membrane NN cord-287815-alv30uk5 367 13 Pathways pathway NNS cord-287815-alv30uk5 367 14 of of IN cord-287815-alv30uk5 367 15 protein protein NN cord-287815-alv30uk5 367 16 secretion secretion NN cord-287815-alv30uk5 367 17 in in IN cord-287815-alv30uk5 367 18 eukaryotes eukaryote NNS cord-287815-alv30uk5 367 19 Elrefeldin Elrefeldin NNP cord-287815-alv30uk5 367 20 A A NNP cord-287815-alv30uk5 367 21 : : : cord-287815-alv30uk5 367 22 cytosolic cytosolic JJ cord-287815-alv30uk5 367 23 coat coat NN cord-287815-alv30uk5 367 24 protein protein NN cord-287815-alv30uk5 367 25 assembly assembly NNP cord-287815-alv30uk5 367 26 , , , cord-287815-alv30uk5 367 27 organelle organelle NN cord-287815-alv30uk5 367 28 structure structure NN cord-287815-alv30uk5 367 29 , , , cord-287815-alv30uk5 367 30 and and CC cord-287815-alv30uk5 367 31 membrane membrane NN cord-287815-alv30uk5 367 32 traffic traffic NN cord-287815-alv30uk5 367 33 Assembly Assembly NNP cord-287815-alv30uk5 367 34 of of IN cord-287815-alv30uk5 367 35 asparagine asparagine NN cord-287815-alv30uk5 367 36 - - HYPH cord-287815-alv30uk5 367 37 linked link VBN cord-287815-alv30uk5 367 38 a a DT cord-287815-alv30uk5 368 1 ~ligosaccharides ~ligosaccharides NFP cord-287815-alv30uk5 368 2 The the DT cord-287815-alv30uk5 368 3 biogenesis biogenesis NN cord-287815-alv30uk5 368 4 of of IN cord-287815-alv30uk5 368 5 lysosomes lysosomes JJ cord-287815-alv30uk5 368 6 Dynamic dynamic JJ cord-287815-alv30uk5 368 7 behavior behavior NN cord-287815-alv30uk5 368 8 of of IN cord-287815-alv30uk5 368 9 endoplasmic endoplasmic NN cord-287815-alv30uk5 368 10 reticulum reticulum NN cord-287815-alv30uk5 368 11 in in IN cord-287815-alv30uk5 368 12 living living NN cord-287815-alv30uk5 368 13 cells cell NNS cord-287815-alv30uk5 369 1 The the DT cord-287815-alv30uk5 369 2 neuronal neuronal JJ cord-287815-alv30uk5 369 3 endomembranesystem endomembranesystem NN cord-287815-alv30uk5 369 4 Microtubule Microtubule NNP cord-287815-alv30uk5 369 5 - - HYPH cord-287815-alv30uk5 369 6 dependent dependent JJ cord-287815-alv30uk5 369 7 retrograde retrograde JJ cord-287815-alv30uk5 369 8 transport transport NN cord-287815-alv30uk5 369 9 of of IN cord-287815-alv30uk5 369 10 proteins protein NNS cord-287815-alv30uk5 369 11 into into IN cord-287815-alv30uk5 369 12 the the DT cord-287815-alv30uk5 369 13 ER ER NNP cord-287815-alv30uk5 369 14 in in IN cord-287815-alv30uk5 369 15 the the DT cord-287815-alv30uk5 369 16 presence presence NN cord-287815-alv30uk5 369 17 of of IN cord-287815-alv30uk5 369 18 brefeldin brefeldin NNP cord-287815-alv30uk5 370 1 A a DT cord-287815-alv30uk5 370 2 suggests suggest VBZ cord-287815-alv30uk5 370 3 an an DT cord-287815-alv30uk5 370 4 ER ER NNP cord-287815-alv30uk5 370 5 recycling recycling NN cord-287815-alv30uk5 370 6 pathway pathway NN cord-287815-alv30uk5 370 7 Brefeldin Brefeldin NNP cord-287815-alv30uk5 370 8 A A NNP cord-287815-alv30uk5 370 9 's 's POS cord-287815-alv30uk5 370 10 effects effect NNS cord-287815-alv30uk5 370 11 on on IN cord-287815-alv30uk5 370 12 endosomes endosome NNS cord-287815-alv30uk5 370 13 , , , cord-287815-alv30uk5 370 14 lysosomes lysosome NNS cord-287815-alv30uk5 370 15 , , , cord-287815-alv30uk5 370 16 and and CC cord-287815-alv30uk5 370 17 the the DT cord-287815-alv30uk5 370 18 TGN TGN NNP cord-287815-alv30uk5 370 19 suggest suggest VBP cord-287815-alv30uk5 370 20 a a DT cord-287815-alv30uk5 370 21 general general JJ cord-287815-alv30uk5 370 22 mechanism mechanism NN cord-287815-alv30uk5 370 23 for for IN cord-287815-alv30uk5 370 24 regulating regulate VBG cord-287815-alv30uk5 370 25 organelle organelle NN cord-287815-alv30uk5 370 26 structure structure NN cord-287815-alv30uk5 370 27 and and CC cord-287815-alv30uk5 370 28 membrane membrane NN cord-287815-alv30uk5 370 29 traffic traffic NN cord-287815-alv30uk5 370 30 Transport transport NN cord-287815-alv30uk5 370 31 of of IN cord-287815-alv30uk5 370 32 secretory secretory NN cord-287815-alv30uk5 370 33 and and CC cord-287815-alv30uk5 370 34 membrane membrane NN cord-287815-alv30uk5 370 35 glycoproteins glycoprotein NNS cord-287815-alv30uk5 370 36 from from IN cord-287815-alv30uk5 370 37 the the DT cord-287815-alv30uk5 370 38 rough rough JJ cord-287815-alv30uk5 370 39 endoplasmic endoplasmic NN cord-287815-alv30uk5 370 40 reticulum reticulum NN cord-287815-alv30uk5 370 41 to to IN cord-287815-alv30uk5 370 42 the the DT cord-287815-alv30uk5 370 43 Golgi Golgi NNP cord-287815-alv30uk5 370 44 Hepatoma Hepatoma NNP cord-287815-alv30uk5 370 45 secretory secretory NN cord-287815-alv30uk5 370 46 proteins protein NNS cord-287815-alv30uk5 370 47 migrate migrate VBP cord-287815-alv30uk5 370 48 from from IN cord-287815-alv30uk5 370 49 the the DT cord-287815-alv30uk5 370 50 rough rough JJ cord-287815-alv30uk5 370 51 endoplasmic endoplasmic NN cord-287815-alv30uk5 370 52 reticulum reticulum NN cord-287815-alv30uk5 370 53 to to IN cord-287815-alv30uk5 370 54 Golgi Golgi NNP cord-287815-alv30uk5 370 55 at at IN cord-287815-alv30uk5 370 56 characteristic characteristic JJ cord-287815-alv30uk5 370 57 rates rate NNS cord-287815-alv30uk5 371 1 Evidence evidence NN cord-287815-alv30uk5 371 2 for for IN cord-287815-alv30uk5 371 3 a a DT cord-287815-alv30uk5 371 4 molecular molecular JJ cord-287815-alv30uk5 371 5 distinction distinction NN cord-287815-alv30uk5 371 6 between between IN cord-287815-alv30uk5 371 7 Golgi Golgi NNP cord-287815-alv30uk5 371 8 and and CC cord-287815-alv30uk5 371 9 cell cell NN cord-287815-alv30uk5 371 10 surface surface NN cord-287815-alv30uk5 371 11 forms form NNS cord-287815-alv30uk5 371 12 of of IN cord-287815-alv30uk5 371 13 Immunocytochemical Immunocytochemical NNP cord-287815-alv30uk5 371 14 analysis analysis NN cord-287815-alv30uk5 371 15 of of IN cord-287815-alv30uk5 371 16 the the DT cord-287815-alv30uk5 371 17 transfer transfer NN cord-287815-alv30uk5 371 18 from from IN cord-287815-alv30uk5 371 19 the the DT cord-287815-alv30uk5 371 20 intermediate intermediate JJ cord-287815-alv30uk5 371 21 compartment compartment NN cord-287815-alv30uk5 371 22 to to IN cord-287815-alv30uk5 371 23 the the DT cord-287815-alv30uk5 371 24 Golgi Golgi NNP cord-287815-alv30uk5 371 25 complex complex NN cord-287815-alv30uk5 371 26 of of IN cord-287815-alv30uk5 371 27 VSV VSV NNP cord-287815-alv30uk5 371 28 G G NNP cord-287815-alv30uk5 371 29 protein protein NN cord-287815-alv30uk5 372 1 The the DT cord-287815-alv30uk5 372 2 El El NNP cord-287815-alv30uk5 372 3 glycoprotein glycoprotein NN cord-287815-alv30uk5 372 4 of of IN cord-287815-alv30uk5 372 5 an an DT cord-287815-alv30uk5 372 6 avian avian JJ cord-287815-alv30uk5 372 7 coronavirus coronavirus NN cord-287815-alv30uk5 372 8 is be VBZ cord-287815-alv30uk5 372 9 targeted target VBN cord-287815-alv30uk5 372 10 to to IN cord-287815-alv30uk5 372 11 the the DT cord-287815-alv30uk5 372 12 cis cis NNP cord-287815-alv30uk5 372 13 Golgi Golgi NNP cord-287815-alv30uk5 372 14 complex complex JJ cord-287815-alv30uk5 372 15 Purification Purification NNP cord-287815-alv30uk5 372 16 of of IN cord-287815-alv30uk5 372 17 a a DT cord-287815-alv30uk5 372 18 novel novel JJ cord-287815-alv30uk5 372 19 class class NN cord-287815-alv30uk5 372 20 of of IN cord-287815-alv30uk5 372 21 coated coated JJ cord-287815-alv30uk5 372 22 vesicles vesicle NNS cord-287815-alv30uk5 372 23 mediating mediate VBG cord-287815-alv30uk5 372 24 biosynthetic biosynthetic JJ cord-287815-alv30uk5 372 25 protein protein NN cord-287815-alv30uk5 372 26 transport transport NN cord-287815-alv30uk5 372 27 through through IN cord-287815-alv30uk5 372 28 the the DT cord-287815-alv30uk5 372 29 Golgi Golgi NNP cord-287815-alv30uk5 372 30 stack stack VB cord-287815-alv30uk5 372 31 Three three CD cord-287815-alv30uk5 372 32 dimensional dimensional JJ cord-287815-alv30uk5 372 33 structure structure NN cord-287815-alv30uk5 372 34 of of IN cord-287815-alv30uk5 372 35 endosomes endosome NNS cord-287815-alv30uk5 372 36 in in IN cord-287815-alv30uk5 372 37 BHK-21 BHK-21 NNP cord-287815-alv30uk5 372 38 cells cell NNS cord-287815-alv30uk5 372 39 Scale scale VBP cord-287815-alv30uk5 372 40 formation formation NN cord-287815-alv30uk5 372 41 rn rn NN cord-287815-alv30uk5 372 42 algae algae NN cord-287815-alv30uk5 372 43 Novel Novel NNP cord-287815-alv30uk5 372 44 blockade blockade NN cord-287815-alv30uk5 372 45 by by IN cord-287815-alv30uk5 372 46 brefeldin brefeldin NNP cord-287815-alv30uk5 372 47 A A NNP cord-287815-alv30uk5 372 48 of of IN cord-287815-alv30uk5 372 49 intracellular intracellular JJ cord-287815-alv30uk5 372 50 transport transport NN cord-287815-alv30uk5 372 51 of of IN cord-287815-alv30uk5 372 52 secretory secretory JJ cord-287815-alv30uk5 372 53 transport transport NN cord-287815-alv30uk5 372 54 of of IN cord-287815-alv30uk5 372 55 secretory secretory JJ cord-287815-alv30uk5 372 56 proteins protein NNS cord-287815-alv30uk5 372 57 in in IN cord-287815-alv30uk5 372 58 cultured cultured JJ cord-287815-alv30uk5 372 59 rat rat NN cord-287815-alv30uk5 372 60 hepatocytes hepatocyte NNS cord-287815-alv30uk5 372 61 Sequences Sequences NNPS cord-287815-alv30uk5 372 62 within within IN cord-287815-alv30uk5 372 63 and and CC cord-287815-alv30uk5 372 64 adjacent adjacent JJ cord-287815-alv30uk5 372 65 to to IN cord-287815-alv30uk5 372 66 the the DT cord-287815-alv30uk5 372 67 transmembrane transmembrane NN cord-287815-alv30uk5 372 68 segment segment NN cord-287815-alv30uk5 372 69 of of IN cord-287815-alv30uk5 372 70 a-2,6sialyltransferase a-2,6sialyltransferase NNP cord-287815-alv30uk5 372 71 specify specify VB cord-287815-alv30uk5 372 72 Golgi Golgi NNP cord-287815-alv30uk5 372 73 retention retention NN cord-287815-alv30uk5 372 74 Recycling recycling NN cord-287815-alv30uk5 372 75 glycoproteins glycoprotein NNS cord-287815-alv30uk5 372 76 do do VBP cord-287815-alv30uk5 372 77 not not RB cord-287815-alv30uk5 372 78 return return VB cord-287815-alv30uk5 372 79 to to IN cord-287815-alv30uk5 372 80 the the DT cord-287815-alv30uk5 372 81 cis cis NNP cord-287815-alv30uk5 372 82 - - HYPH cord-287815-alv30uk5 372 83 Golgi Golgi NNP cord-287815-alv30uk5 373 1 The the DT cord-287815-alv30uk5 373 2 membrane membrane NN cord-287815-alv30uk5 373 3 spanning span VBG cord-287815-alv30uk5 373 4 domain domain NN cord-287815-alv30uk5 373 5 of of IN cord-287815-alv30uk5 373 6 8-l 8-l CD cord-287815-alv30uk5 373 7 , , , cord-287815-alv30uk5 373 8 4-galactosyltransferase 4-galactosyltransferase CD cord-287815-alv30uk5 374 1 specifies specify VBZ cord-287815-alv30uk5 374 2 rrans rrans NNP cord-287815-alv30uk5 374 3 Golgi Golgi NNP cord-287815-alv30uk5 374 4 localization localization NN cord-287815-alv30uk5 375 1 A a DT cord-287815-alv30uk5 375 2 new new JJ cord-287815-alv30uk5 375 3 type type NN cord-287815-alv30uk5 375 4 of of IN cord-287815-alv30uk5 375 5 coated coat VBN cord-287815-alv30uk5 375 6 vesicular vesicular JJ cord-287815-alv30uk5 375 7 carrier carrier NN cord-287815-alv30uk5 375 8 that that WDT cord-287815-alv30uk5 375 9 appears appear VBZ cord-287815-alv30uk5 375 10 not not RB cord-287815-alv30uk5 375 11 to to TO cord-287815-alv30uk5 375 12 contain contain VB cord-287815-alv30uk5 375 13 clathrin clathrin NN cord-287815-alv30uk5 375 14 : : : cord-287815-alv30uk5 375 15 its -PRON- PRP$ cord-287815-alv30uk5 375 16 possible possible JJ cord-287815-alv30uk5 375 17 role role NN cord-287815-alv30uk5 375 18 in in IN cord-287815-alv30uk5 375 19 protein protein NN cord-287815-alv30uk5 375 20 transport transport NN cord-287815-alv30uk5 375 21 within within IN cord-287815-alv30uk5 375 22 the the DT cord-287815-alv30uk5 375 23 Golgi Golgi NNP cord-287815-alv30uk5 375 24 stack stack NN cord-287815-alv30uk5 375 25 Dissection dissection NN cord-287815-alv30uk5 375 26 of of IN cord-287815-alv30uk5 375 27 a a DT cord-287815-alv30uk5 375 28 single single JJ cord-287815-alv30uk5 375 29 round round NN cord-287815-alv30uk5 375 30 of of IN cord-287815-alv30uk5 375 31 vesicular vesicular JJ cord-287815-alv30uk5 375 32 transport transport NN cord-287815-alv30uk5 375 33 : : : cord-287815-alv30uk5 375 34 sequential sequential JJ cord-287815-alv30uk5 375 35 intermediates intermediate NNS cord-287815-alv30uk5 375 36 for for IN cord-287815-alv30uk5 375 37 intercisternal intercisternal JJ cord-287815-alv30uk5 375 38 movement movement NN cord-287815-alv30uk5 375 39 in in IN cord-287815-alv30uk5 375 40 the the DT cord-287815-alv30uk5 375 41 Golgi Golgi NNP cord-287815-alv30uk5 375 42 stack stack NN cord-287815-alv30uk5 375 43 Brefeldin Brefeldin NNP cord-287815-alv30uk5 375 44 A A NNP cord-287815-alv30uk5 375 45 , , , cord-287815-alv30uk5 375 46 a a DT cord-287815-alv30uk5 375 47 drug drug NN cord-287815-alv30uk5 375 48 that that WDT cord-287815-alv30uk5 375 49 blocks block VBZ cord-287815-alv30uk5 375 50 secretion secretion NN cord-287815-alv30uk5 375 51 , , , cord-287815-alv30uk5 375 52 prevents prevent VBZ cord-287815-alv30uk5 375 53 the the DT cord-287815-alv30uk5 375 54 assembly assembly NN cord-287815-alv30uk5 375 55 of of IN cord-287815-alv30uk5 375 56 non non JJ cord-287815-alv30uk5 375 57 - - JJ cord-287815-alv30uk5 375 58 clathrin clathrin JJ cord-287815-alv30uk5 375 59 - - HYPH cord-287815-alv30uk5 375 60 coated coat VBN cord-287815-alv30uk5 375 61 buds bud NNS cord-287815-alv30uk5 375 62 on on IN cord-287815-alv30uk5 375 63 Golgi Golgi NNP cord-287815-alv30uk5 375 64 cisternae cisternae NNP cord-287815-alv30uk5 375 65 Molecular Molecular NNP cord-287815-alv30uk5 375 66 trapping trap VBG cord-287815-alv30uk5 375 67 of of IN cord-287815-alv30uk5 375 68 a a DT cord-287815-alv30uk5 375 69 fluorescent fluorescent JJ cord-287815-alv30uk5 375 70 ceramide ceramide NN cord-287815-alv30uk5 375 71 analogue analogue NN cord-287815-alv30uk5 375 72 at at IN cord-287815-alv30uk5 375 73 the the DT cord-287815-alv30uk5 375 74 Golgi Golgi NNP cord-287815-alv30uk5 375 75 apparatus apparatus NN cord-287815-alv30uk5 375 76 of of IN cord-287815-alv30uk5 375 77 fixed fix VBN cord-287815-alv30uk5 375 78 cells cell NNS cord-287815-alv30uk5 375 79 : : : cord-287815-alv30uk5 375 80 interaction interaction NN cord-287815-alv30uk5 375 81 with with IN cord-287815-alv30uk5 375 82 endogenous endogenous JJ cord-287815-alv30uk5 375 83 lipids lipid NNS cord-287815-alv30uk5 375 84 provides provide VBZ cord-287815-alv30uk5 375 85 a a DT cord-287815-alv30uk5 375 86 trans trans JJ cord-287815-alv30uk5 375 87 - - JJ cord-287815-alv30uk5 375 88 Golgi Golgi NNP cord-287815-alv30uk5 375 89 marker marker NN cord-287815-alv30uk5 375 90 for for IN cord-287815-alv30uk5 375 91 both both DT cord-287815-alv30uk5 375 92 light light NN cord-287815-alv30uk5 375 93 and and CC cord-287815-alv30uk5 375 94 electron electron NN cord-287815-alv30uk5 375 95 microscopy microscopy VBP cord-287815-alv30uk5 375 96 A a DT cord-287815-alv30uk5 375 97 novel novel JJ cord-287815-alv30uk5 375 98 fluorescent fluorescent NN cord-287815-alv30uk5 375 99 ceramide ceramide NN cord-287815-alv30uk5 375 100 analog analog NN cord-287815-alv30uk5 375 101 for for IN cord-287815-alv30uk5 375 102 studying study VBG cord-287815-alv30uk5 375 103 membrane membrane NN cord-287815-alv30uk5 375 104 traffic traffic NN cord-287815-alv30uk5 375 105 in in IN cord-287815-alv30uk5 375 106 animal animal NN cord-287815-alv30uk5 375 107 cells cell NNS cord-287815-alv30uk5 375 108 : : : cord-287815-alv30uk5 375 109 accumulation accumulation NN cord-287815-alv30uk5 375 110 at at IN cord-287815-alv30uk5 375 111 the the DT cord-287815-alv30uk5 375 112 Golgi Golgi NNP cord-287815-alv30uk5 375 113 apparatus apparatus NN cord-287815-alv30uk5 375 114 results result NNS cord-287815-alv30uk5 375 115 in in IN cord-287815-alv30uk5 375 116 altered alter VBN cord-287815-alv30uk5 375 117 spectral spectral JJ cord-287815-alv30uk5 375 118 properties property NNS cord-287815-alv30uk5 375 119 of of IN cord-287815-alv30uk5 375 120 the the DT cord-287815-alv30uk5 375 121 sphingolipid sphingolipid NN cord-287815-alv30uk5 375 122 precursor precursor NN cord-287815-alv30uk5 376 1 Intracellular Intracellular NNP cord-287815-alv30uk5 376 2 aspects aspect NNS cord-287815-alv30uk5 376 3 of of IN cord-287815-alv30uk5 376 4 the the DT cord-287815-alv30uk5 376 5 process process NN cord-287815-alv30uk5 376 6 of of IN cord-287815-alv30uk5 376 7 protein protein NN cord-287815-alv30uk5 376 8 secretion secretion NN cord-287815-alv30uk5 376 9 Clathnn Clathnn NNP cord-287815-alv30uk5 376 10 , , , cord-287815-alv30uk5 376 11 adaptors adaptor NNS cord-287815-alv30uk5 376 12 , , , cord-287815-alv30uk5 376 13 and and CC cord-287815-alv30uk5 376 14 sorting sort VBG cord-287815-alv30uk5 376 15 Evidence evidence NN cord-287815-alv30uk5 376 16 that that IN cord-287815-alv30uk5 376 17 luminal luminal JJ cord-287815-alv30uk5 376 18 ER er NN cord-287815-alv30uk5 376 19 proteins protein NNS cord-287815-alv30uk5 376 20 are be VBP cord-287815-alv30uk5 376 21 sorted sort VBN cord-287815-alv30uk5 376 22 from from IN cord-287815-alv30uk5 376 23 secreted secreted JJ cord-287815-alv30uk5 376 24 proteins protein NNS cord-287815-alv30uk5 376 25 in in IN cord-287815-alv30uk5 376 26 a a DT cord-287815-alv30uk5 376 27 post post JJ cord-287815-alv30uk5 376 28 - - JJ cord-287815-alv30uk5 376 29 ER er JJ cord-287815-alv30uk5 376 30 compartment compartment NN cord-287815-alv30uk5 376 31 Control control NN cord-287815-alv30uk5 376 32 of of IN cord-287815-alv30uk5 376 33 protein protein NN cord-287815-alv30uk5 376 34 exit exit NN cord-287815-alv30uk5 376 35 from from IN cord-287815-alv30uk5 376 36 the the DT cord-287815-alv30uk5 376 37 endoplasmic endoplasmic NN cord-287815-alv30uk5 376 38 reticulum reticulum NN cord-287815-alv30uk5 376 39 Recycling Recycling NNP cord-287815-alv30uk5 376 40 of of IN cord-287815-alv30uk5 376 41 proterns protern NNS cord-287815-alv30uk5 376 42 between between IN cord-287815-alv30uk5 376 43 the the DT cord-287815-alv30uk5 376 44 endoplasmic endoplasmic NN cord-287815-alv30uk5 376 45 reticulum reticulum NN cord-287815-alv30uk5 376 46 and and CC cord-287815-alv30uk5 376 47 Golgi Golgi NNP cord-287815-alv30uk5 376 48 complex complex JJ cord-287815-alv30uk5 376 49 Brosyntheticprotetn Brosyntheticprotetn NNP cord-287815-alv30uk5 376 50 transport transport NN cord-287815-alv30uk5 376 51 and and CC cord-287815-alv30uk5 376 52 sorting sorting NN cord-287815-alv30uk5 376 53 by by IN cord-287815-alv30uk5 376 54 the the DT cord-287815-alv30uk5 376 55 endoplasmic endoplasmic NN cord-287815-alv30uk5 376 56 reticulum reticulum NN cord-287815-alv30uk5 376 57 and and CC cord-287815-alv30uk5 376 58 Golgi Golgi NNP cord-287815-alv30uk5 376 59 Three Three NNP cord-287815-alv30uk5 376 60 - - HYPH cord-287815-alv30uk5 376 61 dimensional dimensional JJ cord-287815-alv30uk5 376 62 electron electron NN cord-287815-alv30uk5 376 63 microscopy microscopy NN cord-287815-alv30uk5 376 64 : : : cord-287815-alv30uk5 376 65 StructureoftheGolgr StructureoftheGolgr NNP cord-287815-alv30uk5 376 66 apparatus apparatus NN cord-287815-alv30uk5 376 67 Perturbation perturbation NN cord-287815-alv30uk5 376 68 of of IN cord-287815-alv30uk5 376 69 the the DT cord-287815-alv30uk5 376 70 morphology morphology NN cord-287815-alv30uk5 376 71 of of IN cord-287815-alv30uk5 376 72 the the DT cord-287815-alv30uk5 376 73 trans trans NNP cord-287815-alv30uk5 376 74 - - NNP cord-287815-alv30uk5 376 75 Golgi Golgi NNP cord-287815-alv30uk5 376 76 network network NN cord-287815-alv30uk5 376 77 following follow VBG cord-287815-alv30uk5 376 78 brefeldin brefeldin NNP cord-287815-alv30uk5 377 1 A a DT cord-287815-alv30uk5 377 2 treatment treatment NN cord-287815-alv30uk5 377 3 : : : cord-287815-alv30uk5 377 4 redistribution redistribution NN cord-287815-alv30uk5 377 5 of of IN cord-287815-alv30uk5 377 6 aTGN atgn JJ cord-287815-alv30uk5 377 7 - - HYPH cord-287815-alv30uk5 377 8 specific specific JJ cord-287815-alv30uk5 377 9 integral integral JJ cord-287815-alv30uk5 377 10 membrane membrane NN cord-287815-alv30uk5 377 11 protein protein NN cord-287815-alv30uk5 377 12 Distinct distinct JJ cord-287815-alv30uk5 377 13 biochemical biochemical JJ cord-287815-alv30uk5 377 14 requirements requirement NNS cord-287815-alv30uk5 377 15 for for IN cord-287815-alv30uk5 377 16 the the DT cord-287815-alv30uk5 377 17 budding budding NN cord-287815-alv30uk5 377 18 , , , cord-287815-alv30uk5 377 19 targeting target VBG cord-287815-alv30uk5 377 20 , , , cord-287815-alv30uk5 377 21 and and CC cord-287815-alv30uk5 377 22 fusion fusion NN cord-287815-alv30uk5 377 23 of of IN cord-287815-alv30uk5 377 24 ER er NN cord-287815-alv30uk5 377 25 - - HYPH cord-287815-alv30uk5 377 26 derived derive VBN cord-287815-alv30uk5 377 27 transport transport NN cord-287815-alv30uk5 377 28 vesicles vesicle NNS cord-287815-alv30uk5 377 29 Post post JJ cord-287815-alv30uk5 377 30 - - JJ cord-287815-alv30uk5 377 31 translational translational JJ cord-287815-alv30uk5 377 32 protein protein NN cord-287815-alv30uk5 377 33 modification modification NN cord-287815-alv30uk5 377 34 in in IN cord-287815-alv30uk5 377 35 the the DT cord-287815-alv30uk5 377 36 endoplasmic endoplasmic NN cord-287815-alv30uk5 377 37 reticulum reticulum NN cord-287815-alv30uk5 377 38 . . . cord-287815-alv30uk5 378 1 Demonstration demonstration NN cord-287815-alv30uk5 378 2 of of IN cord-287815-alv30uk5 378 3 fatty fatty JJ cord-287815-alv30uk5 378 4 acylase acylase NN cord-287815-alv30uk5 378 5 and and CC cord-287815-alv30uk5 378 6 deoxymannoiirimycin deoxymannoiirimycin NNS cord-287815-alv30uk5 378 7 - - HYPH cord-287815-alv30uk5 378 8 sensitive sensitive JJ cord-287815-alv30uk5 378 9 alpha alpha NN cord-287815-alv30uk5 378 10 - - HYPH cord-287815-alv30uk5 378 11 mannosidase mannosidase NN cord-287815-alv30uk5 378 12 activities activity NNS cord-287815-alv30uk5 378 13 lmmunocytochemical lmmunocytochemical JJ cord-287815-alv30uk5 378 14 localization localization NN cord-287815-alv30uk5 378 15 of of IN cord-287815-alv30uk5 378 16 galactosyltransferase galactosyltransferase NNP cord-287815-alv30uk5 378 17 in in IN cord-287815-alv30uk5 378 18 HeLa HeLa NNP cord-287815-alv30uk5 378 19 cells cell NNS cord-287815-alv30uk5 378 20 : : : cord-287815-alv30uk5 378 21 codistribution codistribution NN cord-287815-alv30uk5 378 22 with with IN cord-287815-alv30uk5 378 23 thiamine thiamine NN cord-287815-alv30uk5 378 24 pyrophosphatase pyrophosphatase NN cord-287815-alv30uk5 378 25 in in IN cord-287815-alv30uk5 378 26 the the DT cord-287815-alv30uk5 378 27 trans trans NNP cord-287815-alv30uk5 378 28 - - NNP cord-287815-alv30uk5 378 29 Golgi Golgi NNP cord-287815-alv30uk5 378 30 cisternae cisternae NNP cord-287815-alv30uk5 378 31 Demonstration Demonstration NNP cord-287815-alv30uk5 378 32 of of IN cord-287815-alv30uk5 378 33 an an DT cord-287815-alv30uk5 378 34 extensive extensive JJ cord-287815-alv30uk5 378 35 trans trans JJ cord-287815-alv30uk5 378 36 - - JJ cord-287815-alv30uk5 378 37 tubular tubular JJ cord-287815-alv30uk5 378 38 network network NN cord-287815-alv30uk5 378 39 continuous continuous JJ cord-287815-alv30uk5 378 40 with with IN cord-287815-alv30uk5 378 41 the the DT cord-287815-alv30uk5 378 42 Golgi Golgi NNP cord-287815-alv30uk5 378 43 apparatus apparatus NN cord-287815-alv30uk5 378 44 stack stack NN cord-287815-alv30uk5 378 45 that that WDT cord-287815-alv30uk5 378 46 may may MD cord-287815-alv30uk5 378 47 function function VB cord-287815-alv30uk5 378 48 in in IN cord-287815-alv30uk5 378 49 glycosylation glycosylation NN cord-287815-alv30uk5 378 50 Differential differential NN cord-287815-alv30uk5 378 51 subcompartmentation subcompartmentation NN cord-287815-alv30uk5 378 52 of of IN cord-287815-alv30uk5 378 53 terminal terminal JJ cord-287815-alv30uk5 378 54 glycosylation glycosylation NN cord-287815-alv30uk5 378 55 in in IN cord-287815-alv30uk5 378 56 the the DT cord-287815-alv30uk5 378 57 Golgi Golgi NNP cord-287815-alv30uk5 378 58 apparatus apparatus NN cord-287815-alv30uk5 378 59 of of IN cord-287815-alv30uk5 378 60 intestinal intestinal JJ cord-287815-alv30uk5 378 61 absorptive absorptive JJ cord-287815-alv30uk5 378 62 and and CC cord-287815-alv30uk5 378 63 goblet goblet NN cord-287815-alv30uk5 378 64 cells cell NNS cord-287815-alv30uk5 378 65 Movement Movement NNP cord-287815-alv30uk5 378 66 of of IN cord-287815-alv30uk5 378 67 proteinsthrough proteinsthrough NNP cord-287815-alv30uk5 378 68 the the DT cord-287815-alv30uk5 378 69 Golgi Golgi NNP cord-287815-alv30uk5 378 70 stack stack NN cord-287815-alv30uk5 378 71 : : : cord-287815-alv30uk5 378 72 a a DT cord-287815-alv30uk5 378 73 molecular molecular JJ cord-287815-alv30uk5 378 74 dissection dissection NN cord-287815-alv30uk5 378 75 of of IN cord-287815-alv30uk5 378 76 vesicular vesicular JJ cord-287815-alv30uk5 378 77 transport transport NN cord-287815-alv30uk5 378 78 Intercompartmental Intercompartmental NNP cord-287815-alv30uk5 378 79 transport transport NN cord-287815-alv30uk5 378 80 in in IN cord-287815-alv30uk5 378 81 the the DT cord-287815-alv30uk5 378 82 Golgi Golgi NNP cord-287815-alv30uk5 378 83 complex complex NN cord-287815-alv30uk5 378 84 is be VBZ cord-287815-alv30uk5 378 85 a a DT cord-287815-alv30uk5 378 86 dissociative dissociative JJ cord-287815-alv30uk5 378 87 process process NN cord-287815-alv30uk5 378 88 : : : cord-287815-alv30uk5 378 89 facile facile JJ cord-287815-alv30uk5 378 90 transfer transfer NN cord-287815-alv30uk5 378 91 of of IN cord-287815-alv30uk5 378 92 membrane membrane NN cord-287815-alv30uk5 378 93 protein protein NN cord-287815-alv30uk5 378 94 between between IN cord-287815-alv30uk5 378 95 two two CD cord-287815-alv30uk5 378 96 Golgi Golgi NNP cord-287815-alv30uk5 378 97 populations population NNS cord-287815-alv30uk5 378 98 Transport Transport NNP cord-287815-alv30uk5 378 99 of of IN cord-287815-alv30uk5 378 100 protein protein NN cord-287815-alv30uk5 378 101 between between IN cord-287815-alv30uk5 378 102 cytoplasmic cytoplasmic JJ cord-287815-alv30uk5 378 103 membranes membrane NNS cord-287815-alv30uk5 378 104 of of IN cord-287815-alv30uk5 378 105 fused fuse VBN cord-287815-alv30uk5 378 106 cells cell NNS cord-287815-alv30uk5 378 107 : : : cord-287815-alv30uk5 378 108 correspondence correspondence NN cord-287815-alv30uk5 378 109 to to IN cord-287815-alv30uk5 378 110 processes process NNS cord-287815-alv30uk5 378 111 reconstituted reconstitute VBN cord-287815-alv30uk5 378 112 in in IN cord-287815-alv30uk5 378 113 a a DT cord-287815-alv30uk5 378 114 cell cell NN cord-287815-alv30uk5 378 115 - - HYPH cord-287815-alv30uk5 378 116 free free JJ cord-287815-alv30uk5 378 117 system system NN cord-287815-alv30uk5 378 118 Distribution distribution NN cord-287815-alv30uk5 378 119 of of IN cord-287815-alv30uk5 378 120 the the DT cord-287815-alv30uk5 378 121 intermediate intermediate JJ cord-287815-alv30uk5 378 122 elements element NNS cord-287815-alv30uk5 378 123 operating operate VBG cord-287815-alv30uk5 378 124 in in IN cord-287815-alv30uk5 378 125 ER ER NNP cord-287815-alv30uk5 378 126 to to IN cord-287815-alv30uk5 378 127 Golgi Golgi NNP cord-287815-alv30uk5 378 128 transport transport NN cord-287815-alv30uk5 378 129 Antibodies antibody NNS cord-287815-alv30uk5 378 130 to to IN cord-287815-alv30uk5 378 131 rat rat NN cord-287815-alv30uk5 378 132 pancreas pancreas NN cord-287815-alv30uk5 378 133 Golgi Golgi NNP cord-287815-alv30uk5 378 134 subfractions subfraction NNS cord-287815-alv30uk5 378 135 : : : cord-287815-alv30uk5 378 136 identification identification NN cord-287815-alv30uk5 378 137 of of IN cord-287815-alv30uk5 378 138 a a DT cord-287815-alv30uk5 378 139 58-kD 58-kd CD cord-287815-alv30uk5 378 140 cis cis NNP cord-287815-alv30uk5 378 141 - - HYPH cord-287815-alv30uk5 378 142 Golgi Golgi NNP cord-287815-alv30uk5 378 143 protein protein NN cord-287815-alv30uk5 378 144 Sequential sequential JJ cord-287815-alv30uk5 378 145 transport transport NN cord-287815-alv30uk5 378 146 of of IN cord-287815-alv30uk5 378 147 protein protein NN cord-287815-alv30uk5 378 148 between between IN cord-287815-alv30uk5 378 149 the the DT cord-287815-alv30uk5 378 150 endoplasmic endoplasmic NN cord-287815-alv30uk5 378 151 reticulum reticulum NN cord-287815-alv30uk5 378 152 and and CC cord-287815-alv30uk5 378 153 successive successive JJ cord-287815-alv30uk5 378 154 Golgi Golgi NNP cord-287815-alv30uk5 378 155 compartments compartment NNS cord-287815-alv30uk5 378 156 in in IN cord-287815-alv30uk5 378 157 semi semi JJ cord-287815-alv30uk5 378 158 - - JJ cord-287815-alv30uk5 378 159 intact intact JJ cord-287815-alv30uk5 378 160 cells cell NNS cord-287815-alv30uk5 378 161 Metabolism metabolism NN cord-287815-alv30uk5 378 162 and and CC cord-287815-alv30uk5 378 163 intracellular intracellular JJ cord-287815-alv30uk5 378 164 transport transport NN cord-287815-alv30uk5 378 165 of of IN cord-287815-alv30uk5 378 166 glycosphingolipids glycosphingolipid NNS cord-287815-alv30uk5 378 167 Identification Identification NNP cord-287815-alv30uk5 378 168 , , , cord-287815-alv30uk5 378 169 by by IN cord-287815-alv30uk5 378 170 a a DT cord-287815-alv30uk5 378 171 monoclonal monoclonal JJ cord-287815-alv30uk5 378 172 antibody antibody NN cord-287815-alv30uk5 378 173 , , , cord-287815-alv30uk5 378 174 of of IN cord-287815-alv30uk5 378 175 a a DT cord-287815-alv30uk5 378 176 53 53 CD cord-287815-alv30uk5 378 177 kD kD NNP cord-287815-alv30uk5 378 178 protein protein NN cord-287815-alv30uk5 378 179 associated associate VBN cord-287815-alv30uk5 378 180 with with IN cord-287815-alv30uk5 378 181 a a DT cord-287815-alv30uk5 378 182 tubule tubule NN cord-287815-alv30uk5 378 183 - - HYPH cord-287815-alv30uk5 378 184 vesicular vesicular JJ cord-287815-alv30uk5 378 185 compartment compartment NN cord-287815-alv30uk5 378 186 at at IN cord-287815-alv30uk5 378 187 the the DT cord-287815-alv30uk5 378 188 c&side c&side NN cord-287815-alv30uk5 378 189 of of IN cord-287815-alv30uk5 378 190 the the DT cord-287815-alv30uk5 378 191 Golgi Golgi NNP cord-287815-alv30uk5 378 192 apparatus apparatus NN cord-287815-alv30uk5 378 193 Identification identification NN cord-287815-alv30uk5 378 194 of of IN cord-287815-alv30uk5 378 195 an an DT cord-287815-alv30uk5 378 196 intermediate intermediate JJ cord-287815-alv30uk5 378 197 compartment compartment NN cord-287815-alv30uk5 378 198 involved involve VBN cord-287815-alv30uk5 378 199 in in IN cord-287815-alv30uk5 378 200 protein protein NN cord-287815-alv30uk5 378 201 transport transport NN cord-287815-alv30uk5 378 202 from from IN cord-287815-alv30uk5 378 203 endoplasmic endoplasmic NN cord-287815-alv30uk5 378 204 reticulum reticulum NN cord-287815-alv30uk5 378 205 to to IN cord-287815-alv30uk5 378 206 Golgi Golgi NNP cord-287815-alv30uk5 378 207 apparatus apparatus NN cord-287815-alv30uk5 378 208 A a DT cord-287815-alv30uk5 378 209 coat coat NN cord-287815-alv30uk5 378 210 subunit subunit NN cord-287815-alv30uk5 378 211 of of IN cord-287815-alv30uk5 378 212 Golgi Golgi NNP cord-287815-alv30uk5 378 213 - - HYPH cord-287815-alv30uk5 378 214 derived derive VBN cord-287815-alv30uk5 378 215 nonclathrin nonclathrin NN cord-287815-alv30uk5 378 216 - - HYPH cord-287815-alv30uk5 378 217 coated coat VBN cord-287815-alv30uk5 378 218 vesicles vesicle NNS cord-287815-alv30uk5 378 219 with with IN cord-287815-alv30uk5 378 220 homology homology NN cord-287815-alv30uk5 378 221 to to IN cord-287815-alv30uk5 378 222 the the DT cord-287815-alv30uk5 378 223 clathrin clathrin NN cord-287815-alv30uk5 378 224 - - HYPH cord-287815-alv30uk5 378 225 coated coat VBN cord-287815-alv30uk5 378 226 vesicle vesicle NN cord-287815-alv30uk5 378 227 coat coat NN cord-287815-alv30uk5 378 228 protein protein NN cord-287815-alv30uk5 378 229 8-adaptin 8-adaptin CD cord-287815-alv30uk5 378 230 Lipid lipid NN cord-287815-alv30uk5 378 231 sorting sorting NN cord-287815-alv30uk5 378 232 in in IN cord-287815-alv30uk5 378 233 epithelial epithelial JJ cord-287815-alv30uk5 378 234 cells cell NNS cord-287815-alv30uk5 378 235 lmmunoelectron lmmunoelectron JJ cord-287815-alv30uk5 378 236 microscopic microscopic JJ cord-287815-alv30uk5 378 237 exploration exploration NN cord-287815-alv30uk5 378 238 of of IN cord-287815-alv30uk5 378 239 the the DT cord-287815-alv30uk5 378 240 Golgi Golgi NNP cord-287815-alv30uk5 378 241 complex complex NN cord-287815-alv30uk5 378 242 Sorting sorting NN cord-287815-alv30uk5 378 243 within within IN cord-287815-alv30uk5 378 244 the the DT cord-287815-alv30uk5 378 245 regulated regulate VBN cord-287815-alv30uk5 378 246 secretory secretory JJ cord-287815-alv30uk5 378 247 pathway pathway NN cord-287815-alv30uk5 378 248 occurs occur VBZ cord-287815-alv30uk5 378 249 in in IN cord-287815-alv30uk5 378 250 the the DT cord-287815-alv30uk5 378 251 rrans rrans NNP cord-287815-alv30uk5 378 252 - - HYPH cord-287815-alv30uk5 378 253 Golgi Golgi NNP cord-287815-alv30uk5 378 254 network network NN cord-287815-alv30uk5 378 255 ADP adp NN cord-287815-alv30uk5 378 256 - - HYPH cord-287815-alv30uk5 378 257 ribosylation ribosylation NN cord-287815-alv30uk5 378 258 factor factor NN cord-287815-alv30uk5 378 259 is be VBZ cord-287815-alv30uk5 378 260 functionally functionally RB cord-287815-alv30uk5 378 261 and and CC cord-287815-alv30uk5 378 262 physically physically RB cord-287815-alv30uk5 378 263 associated associate VBN cord-287815-alv30uk5 378 264 with with IN cord-287815-alv30uk5 378 265 the the DT cord-287815-alv30uk5 378 266 Golgi Golgi NNP cord-287815-alv30uk5 378 267 complex complex NN cord-287815-alv30uk5 378 268 Tubular tubular JJ cord-287815-alv30uk5 378 269 lysosome lysosome NN cord-287815-alv30uk5 378 270 morphology morphology NN cord-287815-alv30uk5 378 271 and and CC cord-287815-alv30uk5 378 272 distribution distribution NN cord-287815-alv30uk5 378 273 within within IN cord-287815-alv30uk5 378 274 macrophagesdepend macrophagesdepend NN cord-287815-alv30uk5 378 275 on on IN cord-287815-alv30uk5 378 276 the the DT cord-287815-alv30uk5 378 277 integrity integrity NN cord-287815-alv30uk5 378 278 of of IN cord-287815-alv30uk5 378 279 cytoplasmic cytoplasmic JJ cord-287815-alv30uk5 378 280 microtubules microtubule NNS cord-287815-alv30uk5 378 281 A a DT cord-287815-alv30uk5 378 282 Golgi Golgi NNP cord-287815-alv30uk5 378 283 retention retention NN cord-287815-alv30uk5 378 284 signal signal NN cord-287815-alv30uk5 378 285 in in IN cord-287815-alv30uk5 378 286 a a DT cord-287815-alv30uk5 378 287 membrane membrane NN cord-287815-alv30uk5 378 288 - - HYPH cord-287815-alv30uk5 378 289 spanning span VBG cord-287815-alv30uk5 378 290 domain domain NN cord-287815-alv30uk5 378 291 of of IN cord-287815-alv30uk5 378 292 coronavirus coronavirus NN cord-287815-alv30uk5 378 293 El El NNP cord-287815-alv30uk5 378 294 protein protein NN cord-287815-alv30uk5 378 295 Post Post NNP cord-287815-alv30uk5 378 296 - - NNP cord-287815-alv30uk5 378 297 Golgi Golgi NNP cord-287815-alv30uk5 378 298 apparatus apparatus NN cord-287815-alv30uk5 378 299 localization localization NN cord-287815-alv30uk5 378 300 and and CC cord-287815-alv30uk5 378 301 regional regional JJ cord-287815-alv30uk5 378 302 expression expression NN cord-287815-alv30uk5 378 303 of of IN cord-287815-alv30uk5 378 304 rat rat NN cord-287815-alv30uk5 378 305 intestinal intestinal JJ cord-287815-alv30uk5 378 306 sialyltransferase sialyltransferase NN cord-287815-alv30uk5 378 307 detected detect VBN cord-287815-alv30uk5 378 308 by by IN cord-287815-alv30uk5 378 309 immunoelectron immunoelectron NNP cord-287815-alv30uk5 378 310 microscopy microscopy NNP cord-287815-alv30uk5 378 311 with with IN cord-287815-alv30uk5 378 312 polypeptide polypeptide JJ cord-287815-alv30uk5 378 313 epitope epitope NN cord-287815-alv30uk5 378 314 - - HYPH cord-287815-alv30uk5 378 315 purified purify VBN cord-287815-alv30uk5 378 316 antibody antibody NN cord-287815-alv30uk5 378 317 Brefeldin Brefeldin NNP cord-287815-alv30uk5 378 318 A A NNP cord-287815-alv30uk5 378 319 , , , cord-287815-alv30uk5 378 320 a a DT cord-287815-alv30uk5 378 321 specific specific JJ cord-287815-alv30uk5 378 322 inhibitor inhibitor NN cord-287815-alv30uk5 378 323 of of IN cord-287815-alv30uk5 378 324 intracellular intracellular JJ cord-287815-alv30uk5 378 325 translocation translocation NN cord-287815-alv30uk5 378 326 of of IN cord-287815-alv30uk5 378 327 vesicular vesicular JJ cord-287815-alv30uk5 378 328 stomatitis stomatitis NN cord-287815-alv30uk5 378 329 virus virus NN cord-287815-alv30uk5 378 330 G g NN cord-287815-alv30uk5 378 331 protein protein NN cord-287815-alv30uk5 378 332 : : : cord-287815-alv30uk5 378 333 intracellular intracellular JJ cord-287815-alv30uk5 378 334 accumulation accumulation NN cord-287815-alv30uk5 378 335 of of IN cord-287815-alv30uk5 378 336 high high JJ cord-287815-alv30uk5 378 337 mannose mannose NN cord-287815-alv30uk5 378 338 type type NN cord-287815-alv30uk5 378 339 G g NN cord-287815-alv30uk5 378 340 protein protein NN cord-287815-alv30uk5 378 341 and and CC cord-287815-alv30uk5 378 342 inhibition inhibition NN cord-287815-alv30uk5 378 343 of of IN cord-287815-alv30uk5 378 344 its -PRON- PRP$ cord-287815-alv30uk5 378 345 cell cell NN cord-287815-alv30uk5 378 346 surface surface NN cord-287815-alv30uk5 378 347 expression expression NN cord-287815-alv30uk5 378 348 Microtubules microtubule NNS cord-287815-alv30uk5 378 349 and and CC cord-287815-alv30uk5 378 350 the the DT cord-287815-alv30uk5 378 351 organization organization NN cord-287815-alv30uk5 378 352 of of IN cord-287815-alv30uk5 378 353 the the DT cord-287815-alv30uk5 378 354 Golgi Golgi NNP cord-287815-alv30uk5 378 355 complex complex NN cord-287815-alv30uk5 378 356 Tubular tubular JJ cord-287815-alv30uk5 378 357 endosomal endosomal NN cord-287815-alv30uk5 378 358 networks network NNS cord-287815-alv30uk5 378 359 in in IN cord-287815-alv30uk5 378 360 AtTPO AtTPO NNP cord-287815-alv30uk5 378 361 and and CC cord-287815-alv30uk5 378 362 other other JJ cord-287815-alv30uk5 378 363 cells cell NNS cord-287815-alv30uk5 379 1 Replication replication NN cord-287815-alv30uk5 379 2 ofcoronavirus ofcoronavirus NN cord-287815-alv30uk5 379 3 MHV MHV NNP cord-287815-alv30uk5 379 4 - - HYPH cord-287815-alv30uk5 379 5 A59 A59 NNP cord-287815-alv30uk5 379 6 in in IN cord-287815-alv30uk5 379 7 sac(- sac(- NNP cord-287815-alv30uk5 379 8 ) ) -RRB- cord-287815-alv30uk5 379 9 cells cell NNS cord-287815-alv30uk5 379 10 : : : cord-287815-alv30uk5 379 11 determination determination NN cord-287815-alv30uk5 379 12 of of IN cord-287815-alv30uk5 379 13 the the DT cord-287815-alv30uk5 379 14 first first JJ cord-287815-alv30uk5 379 15 site site NN cord-287815-alv30uk5 379 16 of of IN cord-287815-alv30uk5 379 17 budding budding NN cord-287815-alv30uk5 379 18 of of IN cord-287815-alv30uk5 379 19 progeny progeny JJ cord-287815-alv30uk5 379 20 virions virion NNS cord-287815-alv30uk5 379 21 Site site NN cord-287815-alv30uk5 379 22 of of IN cord-287815-alv30uk5 379 23 addition addition NN cord-287815-alv30uk5 379 24 of of IN cord-287815-alv30uk5 379 25 N n NN cord-287815-alv30uk5 379 26 - - HYPH cord-287815-alv30uk5 379 27 acetyl acetyl NN cord-287815-alv30uk5 379 28 - - HYPH cord-287815-alv30uk5 379 29 galactosamine galactosamine NN cord-287815-alv30uk5 379 30 to to IN cord-287815-alv30uk5 379 31 the the DT cord-287815-alv30uk5 379 32 El El NNP cord-287815-alv30uk5 379 33 glycoprotein glycoprotein NN cord-287815-alv30uk5 379 34 of of IN cord-287815-alv30uk5 379 35 mouse mouse NN cord-287815-alv30uk5 379 36 hepatitis hepatitis NNP cord-287815-alv30uk5 379 37 virusA59 virusA59 . cord-287815-alv30uk5 379 38 Effects effect NNS cord-287815-alv30uk5 379 39 of of IN cord-287815-alv30uk5 379 40 brefeldin brefeldin NNS cord-287815-alv30uk5 379 41 A A NNP cord-287815-alv30uk5 379 42 on on IN cord-287815-alv30uk5 379 43 the the DT cord-287815-alv30uk5 379 44 processing processing NN cord-287815-alv30uk5 379 45 of of IN cord-287815-alv30uk5 379 46 viral viral JJ cord-287815-alv30uk5 379 47 envelope envelope NN cord-287815-alv30uk5 379 48 glycoproteins glycoprotein NNS cord-287815-alv30uk5 379 49 in in IN cord-287815-alv30uk5 379 50 murine murine JJ cord-287815-alv30uk5 379 51 erythroleukemia erythroleukemia NN cord-287815-alv30uk5 379 52 cells cell NNS cord-287815-alv30uk5 379 53 Lipid Lipid VBG cord-287815-alv30uk5 379 54 traffic traffic NN cord-287815-alv30uk5 379 55 in in IN cord-287815-alv30uk5 379 56 animal animal NN cord-287815-alv30uk5 379 57 cells cell NNS cord-287815-alv30uk5 380 1 Distinct distinct JJ cord-287815-alv30uk5 380 2 transport transport NN cord-287815-alv30uk5 380 3 vesicles vesicle NNS cord-287815-alv30uk5 380 4 mediate mediate VBP cord-287815-alv30uk5 380 5 the the DT cord-287815-alv30uk5 380 6 delivery delivery NN cord-287815-alv30uk5 380 7 of of IN cord-287815-alv30uk5 380 8 plasma plasma NN cord-287815-alv30uk5 380 9 membrane membrane NN cord-287815-alv30uk5 380 10 proteins protein NNS cord-287815-alv30uk5 380 11 to to IN cord-287815-alv30uk5 380 12 the the DT cord-287815-alv30uk5 380 13 apical apical JJ cord-287815-alv30uk5 380 14 and and CC cord-287815-alv30uk5 380 15 basolateral basolateral JJ cord-287815-alv30uk5 380 16 domains domain NNS cord-287815-alv30uk5 380 17 of of IN cord-287815-alv30uk5 380 18 MDCK MDCK NNP cord-287815-alv30uk5 380 19 cells cell NNS cord-287815-alv30uk5 380 20 Signals signal NNS cord-287815-alv30uk5 380 21 and and CC cord-287815-alv30uk5 380 22 salvage salvage NN cord-287815-alv30uk5 380 23 sequences sequence NNS cord-287815-alv30uk5 380 24 Purification purification NN cord-287815-alv30uk5 380 25 of of IN cord-287815-alv30uk5 380 26 a a DT cord-287815-alv30uk5 380 27 gal61 gal61 CD cord-287815-alv30uk5 380 28 - - SYM cord-287815-alv30uk5 380 29 4 4 CD cord-287815-alv30uk5 380 30 GlcNAc GlcNAc NNP cord-287815-alv30uk5 380 31 ~12 ~12 CD cord-287815-alv30uk5 380 32 - - HYPH cord-287815-alv30uk5 380 33 6 6 CD cord-287815-alv30uk5 380 34 sialyltransferase sialyltransferase NN cord-287815-alv30uk5 380 35 and and CC cord-287815-alv30uk5 380 36 a a DT cord-287815-alv30uk5 380 37 galpl-3 galpl-3 NNP cord-287815-alv30uk5 380 38 GlcNAc GlcNAc NNP cord-287815-alv30uk5 380 39 a2 a2 NN cord-287815-alv30uk5 380 40 - - HYPH cord-287815-alv30uk5 380 41 3 3 CD cord-287815-alv30uk5 380 42 sialyltransferase sialyltransferase NN cord-287815-alv30uk5 380 43 to to IN cord-287815-alv30uk5 380 44 homogeneity homogeneity NN cord-287815-alv30uk5 380 45 from from IN cord-287815-alv30uk5 380 46 rat rat NN cord-287815-alv30uk5 380 47 liver liver NN cord-287815-alv30uk5 381 1 The the DT cord-287815-alv30uk5 381 2 rate rate NN cord-287815-alv30uk5 381 3 of of IN cord-287815-alv30uk5 381 4 bulk bulk JJ cord-287815-alv30uk5 381 5 flow flow NN cord-287815-alv30uk5 381 6 from from IN cord-287815-alv30uk5 381 7 the the DT cord-287815-alv30uk5 381 8 endoplasmic endoplasmic NN cord-287815-alv30uk5 381 9 reticulum reticulum NN cord-287815-alv30uk5 381 10 to to IN cord-287815-alv30uk5 381 11 the the DT cord-287815-alv30uk5 381 12 cell cell NN cord-287815-alv30uk5 381 13 surface surface NN cord-287815-alv30uk5 381 14 A a DT cord-287815-alv30uk5 381 15 fusion fusion NN cord-287815-alv30uk5 381 16 protein protein NN cord-287815-alv30uk5 381 17 required require VBN cord-287815-alv30uk5 381 18 for for IN cord-287815-alv30uk5 381 19 vesicle vesicle NN cord-287815-alv30uk5 381 20 - - HYPH cord-287815-alv30uk5 381 21 mediated mediate VBN cord-287815-alv30uk5 381 22 transport transport NN cord-287815-alv30uk5 381 23 in in IN cord-287815-alv30uk5 381 24 both both DT cord-287815-alv30uk5 381 25 mammalian mammalian JJ cord-287815-alv30uk5 381 26 cells cell NNS cord-287815-alv30uk5 381 27 and and CC cord-287815-alv30uk5 381 28 yeast yeast NN cord-287815-alv30uk5 381 29 Three three CD cord-287815-alv30uk5 381 30 - - HYPH cord-287815-alv30uk5 381 31 dimensional dimensional JJ cord-287815-alv30uk5 381 32 reconstruction reconstruction NN cord-287815-alv30uk5 381 33 of of IN cord-287815-alv30uk5 381 34 a a DT cord-287815-alv30uk5 381 35 peroxisomal peroxisomal JJ cord-287815-alv30uk5 381 36 reticulum reticulum NN cord-287815-alv30uk5 381 37 in in IN cord-287815-alv30uk5 381 38 regenerating regenerate VBG cord-287815-alv30uk5 381 39 rat rat NN cord-287815-alv30uk5 381 40 liver liver NN cord-287815-alv30uk5 381 41 : : : cord-287815-alv30uk5 381 42 evidence evidence NN cord-287815-alv30uk5 381 43 of of IN cord-287815-alv30uk5 381 44 interconnections interconnection NNS cord-287815-alv30uk5 381 45 between between IN cord-287815-alv30uk5 381 46 heterogeneous heterogeneous JJ cord-287815-alv30uk5 381 47 segments segment NNS cord-287815-alv30uk5 381 48 We -PRON- PRP cord-287815-alv30uk5 381 49 are be VBP cord-287815-alv30uk5 381 50 indebted indebted JJ cord-287815-alv30uk5 381 51 to to IN cord-287815-alv30uk5 381 52 the the DT cord-287815-alv30uk5 381 53 many many JJ cord-287815-alv30uk5 381 54 friends friend NNS cord-287815-alv30uk5 381 55 and and CC cord-287815-alv30uk5 381 56 colleagues colleague NNS cord-287815-alv30uk5 381 57 who who WP cord-287815-alv30uk5 381 58 read read VBD cord-287815-alv30uk5 381 59 , , , cord-287815-alv30uk5 381 60 criticized criticize VBN cord-287815-alv30uk5 381 61 , , , cord-287815-alv30uk5 381 62 or or CC cord-287815-alv30uk5 381 63 otherwise otherwise RB cord-287815-alv30uk5 381 64 contributed contribute VBN cord-287815-alv30uk5 381 65 during during IN cord-287815-alv30uk5 381 66 the the DT cord-287815-alv30uk5 381 67 evolution evolution NN cord-287815-alv30uk5 381 68 of of IN cord-287815-alv30uk5 381 69 this this DT cord-287815-alv30uk5 381 70 review review NN cord-287815-alv30uk5 381 71 . . . cord-287815-alv30uk5 382 1 In in IN cord-287815-alv30uk5 382 2 particular particular JJ cord-287815-alv30uk5 382 3 , , , cord-287815-alv30uk5 382 4 wewould wewould NNP cord-287815-alv30uk5 382 5 liketo liketo VB cord-287815-alv30uk5 382 6 thanksuzannepfeffer thanksuzannepfeffer VB cord-287815-alv30uk5 382 7 , , , cord-287815-alv30uk5 382 8 Jim Jim NNP cord-287815-alv30uk5 382 9 Rothman Rothman NNP cord-287815-alv30uk5 382 10 , , , cord-287815-alv30uk5 382 11 Pietro Pietro NNP cord-287815-alv30uk5 382 12 De De NNP cord-287815-alv30uk5 382 13 Camilli Camilli NNP cord-287815-alv30uk5 382 14 , , , cord-287815-alv30uk5 382 15 Marylin Marylin NNP cord-287815-alv30uk5 382 16 Farquhar Farquhar NNP cord-287815-alv30uk5 382 17 , , , cord-287815-alv30uk5 382 18 Rick Rick NNP cord-287815-alv30uk5 382 19 Klausner Klausner NNP cord-287815-alv30uk5 382 20 , , , cord-287815-alv30uk5 382 21 Ari Ari NNP cord-287815-alv30uk5 382 22 Helenius Helenius NNP cord-287815-alv30uk5 382 23 , , , cord-287815-alv30uk5 382 24 Regis Regis NNP cord-287815-alv30uk5 382 25 Kelly Kelly NNP cord-287815-alv30uk5 382 26 , , , cord-287815-alv30uk5 382 27 and and CC cord-287815-alv30uk5 382 28 Graham Graham NNP cord-287815-alv30uk5 382 29 Warren Warren NNP cord-287815-alv30uk5 382 30 , , , cord-287815-alv30uk5 382 31 each each DT cord-287815-alv30uk5 382 32 of of IN cord-287815-alv30uk5 382 33 whom whom WP cord-287815-alv30uk5 382 34 devoted devote VBD cord-287815-alv30uk5 382 35 a a DT cord-287815-alv30uk5 382 36 considerable considerable JJ cord-287815-alv30uk5 382 37 amount amount NN cord-287815-alv30uk5 382 38 of of IN cord-287815-alv30uk5 382 39 time time NN cord-287815-alv30uk5 382 40 and and CC cord-287815-alv30uk5 382 41 effort effort NN cord-287815-alv30uk5 382 42 . . .