id sid tid token lemma pos cord-328289-3h3kmjlz 1 1 key key JJ cord-328289-3h3kmjlz 1 2 : : : cord-328289-3h3kmjlz 1 3 cord-328289 cord-328289 NN cord-328289-3h3kmjlz 1 4 - - HYPH cord-328289-3h3kmjlz 1 5 3h3kmjlz 3h3kmjlz JJ cord-328289-3h3kmjlz 1 6 authors author NNS cord-328289-3h3kmjlz 1 7 : : : cord-328289-3h3kmjlz 1 8 Iadecola Iadecola NNP cord-328289-3h3kmjlz 1 9 , , , cord-328289-3h3kmjlz 1 10 Costantino Costantino NNP cord-328289-3h3kmjlz 1 11 ; ; : cord-328289-3h3kmjlz 1 12 Anrather Anrather NNP cord-328289-3h3kmjlz 1 13 , , , cord-328289-3h3kmjlz 1 14 Josef Josef NNP cord-328289-3h3kmjlz 1 15 ; ; : cord-328289-3h3kmjlz 1 16 Kamel Kamel NNP cord-328289-3h3kmjlz 1 17 , , , cord-328289-3h3kmjlz 1 18 Hooman Hooman NNP cord-328289-3h3kmjlz 1 19 title title NN cord-328289-3h3kmjlz 1 20 : : : cord-328289-3h3kmjlz 1 21 Effects effect NNS cord-328289-3h3kmjlz 1 22 of of IN cord-328289-3h3kmjlz 1 23 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 1 24 on on IN cord-328289-3h3kmjlz 1 25 the the DT cord-328289-3h3kmjlz 1 26 nervous nervous JJ cord-328289-3h3kmjlz 1 27 system system NN cord-328289-3h3kmjlz 1 28 date date NN cord-328289-3h3kmjlz 1 29 : : : cord-328289-3h3kmjlz 1 30 2020 2020 CD cord-328289-3h3kmjlz 1 31 - - HYPH cord-328289-3h3kmjlz 1 32 08 08 CD cord-328289-3h3kmjlz 1 33 - - SYM cord-328289-3h3kmjlz 1 34 19 19 CD cord-328289-3h3kmjlz 1 35 journal journal NN cord-328289-3h3kmjlz 1 36 : : : cord-328289-3h3kmjlz 2 1 Cell cell NN cord-328289-3h3kmjlz 2 2 DOI doi NN cord-328289-3h3kmjlz 2 3 : : : cord-328289-3h3kmjlz 2 4 10.1016 10.1016 CD cord-328289-3h3kmjlz 2 5 / / SYM cord-328289-3h3kmjlz 2 6 j.cell.2020.08.028 j.cell.2020.08.028 NN cord-328289-3h3kmjlz 2 7 sha sha XX cord-328289-3h3kmjlz 2 8 : : : cord-328289-3h3kmjlz 2 9 dd7b62b884f8b7228aee5fa24a41812a7e7f2c06 dd7b62b884f8b7228aee5fa24a41812a7e7f2c06 ADD cord-328289-3h3kmjlz 2 10 doc_id doc_id CD cord-328289-3h3kmjlz 2 11 : : : cord-328289-3h3kmjlz 3 1 328289 328289 CD cord-328289-3h3kmjlz 3 2 cord_uid cord_uid NNS cord-328289-3h3kmjlz 3 3 : : : cord-328289-3h3kmjlz 3 4 3h3kmjlz 3h3kmjlz NNP cord-328289-3h3kmjlz 3 5 Summary Summary NNP cord-328289-3h3kmjlz 3 6 Neurological Neurological NNP cord-328289-3h3kmjlz 3 7 complications complication NNS cord-328289-3h3kmjlz 3 8 have have VBP cord-328289-3h3kmjlz 3 9 emerged emerge VBN cord-328289-3h3kmjlz 3 10 as as IN cord-328289-3h3kmjlz 3 11 a a DT cord-328289-3h3kmjlz 3 12 significant significant JJ cord-328289-3h3kmjlz 3 13 cause cause NN cord-328289-3h3kmjlz 3 14 of of IN cord-328289-3h3kmjlz 3 15 morbidity morbidity NN cord-328289-3h3kmjlz 3 16 and and CC cord-328289-3h3kmjlz 3 17 mortality mortality NN cord-328289-3h3kmjlz 3 18 in in IN cord-328289-3h3kmjlz 3 19 the the DT cord-328289-3h3kmjlz 3 20 ongoing ongoing JJ cord-328289-3h3kmjlz 3 21 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 3 22 pandemic pandemic NN cord-328289-3h3kmjlz 3 23 . . . cord-328289-3h3kmjlz 4 1 Beside beside IN cord-328289-3h3kmjlz 4 2 respiratory respiratory JJ cord-328289-3h3kmjlz 4 3 insufficiency insufficiency NN cord-328289-3h3kmjlz 4 4 , , , cord-328289-3h3kmjlz 4 5 many many JJ cord-328289-3h3kmjlz 4 6 hospitalized hospitalize VBN cord-328289-3h3kmjlz 4 7 patients patient NNS cord-328289-3h3kmjlz 4 8 exhibit exhibit VBP cord-328289-3h3kmjlz 4 9 neurological neurological JJ cord-328289-3h3kmjlz 4 10 manifestations manifestation NNS cord-328289-3h3kmjlz 4 11 , , , cord-328289-3h3kmjlz 4 12 ranging range VBG cord-328289-3h3kmjlz 4 13 from from IN cord-328289-3h3kmjlz 4 14 headache headache NN cord-328289-3h3kmjlz 4 15 and and CC cord-328289-3h3kmjlz 4 16 loss loss NN cord-328289-3h3kmjlz 4 17 of of IN cord-328289-3h3kmjlz 4 18 smell smell NN cord-328289-3h3kmjlz 4 19 , , , cord-328289-3h3kmjlz 4 20 to to IN cord-328289-3h3kmjlz 4 21 confusion confusion NN cord-328289-3h3kmjlz 4 22 and and CC cord-328289-3h3kmjlz 4 23 disabling disable VBG cord-328289-3h3kmjlz 4 24 strokes stroke NNS cord-328289-3h3kmjlz 4 25 . . . cord-328289-3h3kmjlz 5 1 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 5 2 is be VBZ cord-328289-3h3kmjlz 5 3 also also RB cord-328289-3h3kmjlz 5 4 anticipated anticipate VBN cord-328289-3h3kmjlz 5 5 to to TO cord-328289-3h3kmjlz 5 6 take take VB cord-328289-3h3kmjlz 5 7 a a DT cord-328289-3h3kmjlz 5 8 toll toll NN cord-328289-3h3kmjlz 5 9 on on IN cord-328289-3h3kmjlz 5 10 the the DT cord-328289-3h3kmjlz 5 11 nervous nervous JJ cord-328289-3h3kmjlz 5 12 system system NN cord-328289-3h3kmjlz 5 13 in in IN cord-328289-3h3kmjlz 5 14 the the DT cord-328289-3h3kmjlz 5 15 long long JJ cord-328289-3h3kmjlz 5 16 term term NN cord-328289-3h3kmjlz 5 17 . . . cord-328289-3h3kmjlz 6 1 Here here RB cord-328289-3h3kmjlz 6 2 we -PRON- PRP cord-328289-3h3kmjlz 6 3 will will MD cord-328289-3h3kmjlz 6 4 provide provide VB cord-328289-3h3kmjlz 6 5 a a DT cord-328289-3h3kmjlz 6 6 critical critical JJ cord-328289-3h3kmjlz 6 7 appraisal appraisal NN cord-328289-3h3kmjlz 6 8 of of IN cord-328289-3h3kmjlz 6 9 the the DT cord-328289-3h3kmjlz 6 10 potential potential NN cord-328289-3h3kmjlz 6 11 for for IN cord-328289-3h3kmjlz 6 12 neurotropism neurotropism NN cord-328289-3h3kmjlz 6 13 and and CC cord-328289-3h3kmjlz 6 14 mechanisms mechanism NNS cord-328289-3h3kmjlz 6 15 of of IN cord-328289-3h3kmjlz 6 16 neuropathogenesis neuropathogenesis NN cord-328289-3h3kmjlz 6 17 of of IN cord-328289-3h3kmjlz 6 18 SARS SARS NNP cord-328289-3h3kmjlz 6 19 - - HYPH cord-328289-3h3kmjlz 6 20 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 6 21 , , , cord-328289-3h3kmjlz 6 22 as as IN cord-328289-3h3kmjlz 6 23 they -PRON- PRP cord-328289-3h3kmjlz 6 24 relate relate VBP cord-328289-3h3kmjlz 6 25 to to IN cord-328289-3h3kmjlz 6 26 the the DT cord-328289-3h3kmjlz 6 27 acute acute JJ cord-328289-3h3kmjlz 6 28 and and CC cord-328289-3h3kmjlz 6 29 chronic chronic JJ cord-328289-3h3kmjlz 6 30 neurological neurological JJ cord-328289-3h3kmjlz 6 31 consequences consequence NNS cord-328289-3h3kmjlz 6 32 of of IN cord-328289-3h3kmjlz 6 33 the the DT cord-328289-3h3kmjlz 6 34 infection infection NN cord-328289-3h3kmjlz 6 35 . . . cord-328289-3h3kmjlz 7 1 Finally finally RB cord-328289-3h3kmjlz 7 2 , , , cord-328289-3h3kmjlz 7 3 we -PRON- PRP cord-328289-3h3kmjlz 7 4 will will MD cord-328289-3h3kmjlz 7 5 examine examine VB cord-328289-3h3kmjlz 7 6 potential potential JJ cord-328289-3h3kmjlz 7 7 avenues avenue NNS cord-328289-3h3kmjlz 7 8 for for IN cord-328289-3h3kmjlz 7 9 future future JJ cord-328289-3h3kmjlz 7 10 research research NN cord-328289-3h3kmjlz 7 11 and and CC cord-328289-3h3kmjlz 7 12 therapeutic therapeutic JJ cord-328289-3h3kmjlz 7 13 development development NN cord-328289-3h3kmjlz 7 14 . . . cord-328289-3h3kmjlz 8 1 Neurological neurological JJ cord-328289-3h3kmjlz 8 2 complications complication NNS cord-328289-3h3kmjlz 8 3 have have VBP cord-328289-3h3kmjlz 8 4 emerged emerge VBN cord-328289-3h3kmjlz 8 5 as as IN cord-328289-3h3kmjlz 8 6 a a DT cord-328289-3h3kmjlz 8 7 significant significant JJ cord-328289-3h3kmjlz 8 8 cause cause NN cord-328289-3h3kmjlz 8 9 of of IN cord-328289-3h3kmjlz 8 10 morbidity morbidity NN cord-328289-3h3kmjlz 8 11 and and CC cord-328289-3h3kmjlz 8 12 mortality mortality NN cord-328289-3h3kmjlz 8 13 in in IN cord-328289-3h3kmjlz 8 14 the the DT cord-328289-3h3kmjlz 8 15 ongoing ongoing JJ cord-328289-3h3kmjlz 8 16 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 8 17 pandemic pandemic NN cord-328289-3h3kmjlz 8 18 . . . cord-328289-3h3kmjlz 9 1 Beside beside IN cord-328289-3h3kmjlz 9 2 respiratory respiratory JJ cord-328289-3h3kmjlz 9 3 insufficiency insufficiency NN cord-328289-3h3kmjlz 9 4 , , , cord-328289-3h3kmjlz 9 5 many many JJ cord-328289-3h3kmjlz 9 6 hospitalized hospitalize VBN cord-328289-3h3kmjlz 9 7 patients patient NNS cord-328289-3h3kmjlz 9 8 exhibit exhibit VBP cord-328289-3h3kmjlz 9 9 neurological neurological JJ cord-328289-3h3kmjlz 9 10 manifestations manifestation NNS cord-328289-3h3kmjlz 9 11 , , , cord-328289-3h3kmjlz 9 12 ranging range VBG cord-328289-3h3kmjlz 9 13 from from IN cord-328289-3h3kmjlz 9 14 headache headache NN cord-328289-3h3kmjlz 9 15 and and CC cord-328289-3h3kmjlz 9 16 loss loss NN cord-328289-3h3kmjlz 9 17 of of IN cord-328289-3h3kmjlz 9 18 smell smell NN cord-328289-3h3kmjlz 9 19 , , , cord-328289-3h3kmjlz 9 20 to to IN cord-328289-3h3kmjlz 9 21 confusion confusion NN cord-328289-3h3kmjlz 9 22 and and CC cord-328289-3h3kmjlz 9 23 disabling disable VBG cord-328289-3h3kmjlz 9 24 strokes stroke NNS cord-328289-3h3kmjlz 9 25 . . . cord-328289-3h3kmjlz 10 1 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 10 2 is be VBZ cord-328289-3h3kmjlz 10 3 also also RB cord-328289-3h3kmjlz 10 4 anticipated anticipate VBN cord-328289-3h3kmjlz 10 5 to to TO cord-328289-3h3kmjlz 10 6 take take VB cord-328289-3h3kmjlz 10 7 a a DT cord-328289-3h3kmjlz 10 8 toll toll NN cord-328289-3h3kmjlz 10 9 on on IN cord-328289-3h3kmjlz 10 10 the the DT cord-328289-3h3kmjlz 10 11 nervous nervous JJ cord-328289-3h3kmjlz 10 12 system system NN cord-328289-3h3kmjlz 10 13 in in IN cord-328289-3h3kmjlz 10 14 the the DT cord-328289-3h3kmjlz 10 15 long long JJ cord-328289-3h3kmjlz 10 16 term term NN cord-328289-3h3kmjlz 10 17 . . . cord-328289-3h3kmjlz 11 1 Here here RB cord-328289-3h3kmjlz 11 2 we -PRON- PRP cord-328289-3h3kmjlz 11 3 will will MD cord-328289-3h3kmjlz 11 4 provide provide VB cord-328289-3h3kmjlz 11 5 a a DT cord-328289-3h3kmjlz 11 6 critical critical JJ cord-328289-3h3kmjlz 11 7 appraisal appraisal NN cord-328289-3h3kmjlz 11 8 of of IN cord-328289-3h3kmjlz 11 9 the the DT cord-328289-3h3kmjlz 11 10 potential potential NN cord-328289-3h3kmjlz 11 11 for for IN cord-328289-3h3kmjlz 11 12 neurotropism neurotropism NN cord-328289-3h3kmjlz 11 13 and and CC cord-328289-3h3kmjlz 11 14 mechanisms mechanism NNS cord-328289-3h3kmjlz 11 15 of of IN cord-328289-3h3kmjlz 11 16 neuropathogenesis neuropathogenesis NN cord-328289-3h3kmjlz 11 17 of of IN cord-328289-3h3kmjlz 11 18 SARS SARS NNP cord-328289-3h3kmjlz 11 19 - - HYPH cord-328289-3h3kmjlz 11 20 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 11 21 , , , cord-328289-3h3kmjlz 11 22 as as IN cord-328289-3h3kmjlz 11 23 they -PRON- PRP cord-328289-3h3kmjlz 11 24 relate relate VBP cord-328289-3h3kmjlz 11 25 to to IN cord-328289-3h3kmjlz 11 26 the the DT cord-328289-3h3kmjlz 11 27 acute acute JJ cord-328289-3h3kmjlz 11 28 and and CC cord-328289-3h3kmjlz 11 29 chronic chronic JJ cord-328289-3h3kmjlz 11 30 neurological neurological JJ cord-328289-3h3kmjlz 11 31 consequences consequence NNS cord-328289-3h3kmjlz 11 32 of of IN cord-328289-3h3kmjlz 11 33 the the DT cord-328289-3h3kmjlz 11 34 infection infection NN cord-328289-3h3kmjlz 11 35 . . . cord-328289-3h3kmjlz 12 1 Finally finally RB cord-328289-3h3kmjlz 12 2 , , , cord-328289-3h3kmjlz 12 3 we -PRON- PRP cord-328289-3h3kmjlz 12 4 will will MD cord-328289-3h3kmjlz 12 5 examine examine VB cord-328289-3h3kmjlz 12 6 potential potential JJ cord-328289-3h3kmjlz 12 7 avenues avenue NNS cord-328289-3h3kmjlz 12 8 for for IN cord-328289-3h3kmjlz 12 9 future future JJ cord-328289-3h3kmjlz 12 10 research research NN cord-328289-3h3kmjlz 12 11 and and CC cord-328289-3h3kmjlz 12 12 therapeutic therapeutic JJ cord-328289-3h3kmjlz 12 13 development development NN cord-328289-3h3kmjlz 12 14 . . . cord-328289-3h3kmjlz 13 1 There there EX cord-328289-3h3kmjlz 13 2 is be VBZ cord-328289-3h3kmjlz 13 3 increasing increase VBG cord-328289-3h3kmjlz 13 4 evidence evidence NN cord-328289-3h3kmjlz 13 5 that that IN cord-328289-3h3kmjlz 13 6 the the DT cord-328289-3h3kmjlz 13 7 nervous nervous JJ cord-328289-3h3kmjlz 13 8 system system NN cord-328289-3h3kmjlz 13 9 is be VBZ cord-328289-3h3kmjlz 13 10 frequently frequently RB cord-328289-3h3kmjlz 13 11 involved involve VBN cord-328289-3h3kmjlz 13 12 in in IN cord-328289-3h3kmjlz 13 13 patients patient NNS cord-328289-3h3kmjlz 13 14 hospitalized hospitalize VBN cord-328289-3h3kmjlz 13 15 with with IN cord-328289-3h3kmjlz 13 16 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 13 17 Disease Disease NNP cord-328289-3h3kmjlz 13 18 2019 2019 CD cord-328289-3h3kmjlz 13 19 . . . cord-328289-3h3kmjlz 14 1 This this DT cord-328289-3h3kmjlz 14 2 is be VBZ cord-328289-3h3kmjlz 14 3 not not RB cord-328289-3h3kmjlz 14 4 surprising surprising JJ cord-328289-3h3kmjlz 14 5 since since IN cord-328289-3h3kmjlz 14 6 neurological neurological JJ cord-328289-3h3kmjlz 14 7 manifestations manifestation NNS cord-328289-3h3kmjlz 14 8 have have VBP cord-328289-3h3kmjlz 14 9 long long RB cord-328289-3h3kmjlz 14 10 been be VBN cord-328289-3h3kmjlz 14 11 described describe VBN cord-328289-3h3kmjlz 14 12 also also RB cord-328289-3h3kmjlz 14 13 in in IN cord-328289-3h3kmjlz 14 14 infections infection NNS cord-328289-3h3kmjlz 14 15 from from IN cord-328289-3h3kmjlz 14 16 other other JJ cord-328289-3h3kmjlz 14 17 respiratory respiratory JJ cord-328289-3h3kmjlz 14 18 viruses virus NNS cord-328289-3h3kmjlz 14 19 , , , cord-328289-3h3kmjlz 14 20 including include VBG cord-328289-3h3kmjlz 14 21 coronaviruses coronaviruse NNS cord-328289-3h3kmjlz 14 22 ( ( -LRB- cord-328289-3h3kmjlz 14 23 Bergmann Bergmann NNP cord-328289-3h3kmjlz 14 24 et et NNP cord-328289-3h3kmjlz 14 25 al al NNP cord-328289-3h3kmjlz 14 26 . . NNP cord-328289-3h3kmjlz 14 27 , , , cord-328289-3h3kmjlz 14 28 2006 2006 CD cord-328289-3h3kmjlz 14 29 ) ) -RRB- cord-328289-3h3kmjlz 14 30 . . . cord-328289-3h3kmjlz 15 1 However however RB cord-328289-3h3kmjlz 15 2 , , , cord-328289-3h3kmjlz 15 3 the the DT cord-328289-3h3kmjlz 15 4 neurological neurological JJ cord-328289-3h3kmjlz 15 5 manifestations manifestation NNS cord-328289-3h3kmjlz 15 6 of of IN cord-328289-3h3kmjlz 15 7 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 15 8 are be VBP cord-328289-3h3kmjlz 15 9 common common JJ cord-328289-3h3kmjlz 15 10 and and CC cord-328289-3h3kmjlz 15 11 disabling disable VBG cord-328289-3h3kmjlz 15 12 enough enough RB cord-328289-3h3kmjlz 15 13 to to TO cord-328289-3h3kmjlz 15 14 have have VB cord-328289-3h3kmjlz 15 15 attracted attract VBN cord-328289-3h3kmjlz 15 16 widespread widespread JJ cord-328289-3h3kmjlz 15 17 attention attention NN cord-328289-3h3kmjlz 15 18 in in IN cord-328289-3h3kmjlz 15 19 the the DT cord-328289-3h3kmjlz 15 20 scientific scientific JJ cord-328289-3h3kmjlz 15 21 and and CC cord-328289-3h3kmjlz 15 22 lay lay JJ cord-328289-3h3kmjlz 15 23 press press NN cord-328289-3h3kmjlz 15 24 for for IN cord-328289-3h3kmjlz 15 25 their -PRON- PRP$ cord-328289-3h3kmjlz 15 26 short short JJ cord-328289-3h3kmjlz 15 27 - - HYPH cord-328289-3h3kmjlz 15 28 and and CC cord-328289-3h3kmjlz 15 29 long long JJ cord-328289-3h3kmjlz 15 30 - - HYPH cord-328289-3h3kmjlz 15 31 term term NN cord-328289-3h3kmjlz 15 32 impact impact NN cord-328289-3h3kmjlz 15 33 on on IN cord-328289-3h3kmjlz 15 34 population population NN cord-328289-3h3kmjlz 15 35 health health NN cord-328289-3h3kmjlz 16 1 ( ( -LRB- cord-328289-3h3kmjlz 16 2 Pleasure pleasure NN cord-328289-3h3kmjlz 16 3 et et FW cord-328289-3h3kmjlz 16 4 al al NNP cord-328289-3h3kmjlz 16 5 . . NNP cord-328289-3h3kmjlz 16 6 , , , cord-328289-3h3kmjlz 16 7 2020 2020 CD cord-328289-3h3kmjlz 16 8 ; ; : cord-328289-3h3kmjlz 16 9 Wenner Wenner NNP cord-328289-3h3kmjlz 16 10 Moyer Moyer NNP cord-328289-3h3kmjlz 16 11 , , , cord-328289-3h3kmjlz 16 12 2020 2020 CD cord-328289-3h3kmjlz 16 13 ) ) -RRB- cord-328289-3h3kmjlz 16 14 . . . cord-328289-3h3kmjlz 17 1 A a DT cord-328289-3h3kmjlz 17 2 large large JJ cord-328289-3h3kmjlz 17 3 body body NN cord-328289-3h3kmjlz 17 4 of of IN cord-328289-3h3kmjlz 17 5 clinical clinical JJ cord-328289-3h3kmjlz 17 6 data datum NNS cord-328289-3h3kmjlz 17 7 from from IN cord-328289-3h3kmjlz 17 8 tertiary tertiary JJ cord-328289-3h3kmjlz 17 9 referral referral NN cord-328289-3h3kmjlz 17 10 centers center NNS cord-328289-3h3kmjlz 17 11 is be VBZ cord-328289-3h3kmjlz 17 12 rapidly rapidly RB cord-328289-3h3kmjlz 17 13 accumulating accumulate VBG cord-328289-3h3kmjlz 17 14 on on IN cord-328289-3h3kmjlz 17 15 this this DT cord-328289-3h3kmjlz 17 16 topic topic NN cord-328289-3h3kmjlz 17 17 worldwide worldwide RB cord-328289-3h3kmjlz 17 18 , , , cord-328289-3h3kmjlz 17 19 often often RB cord-328289-3h3kmjlz 17 20 with with IN cord-328289-3h3kmjlz 17 21 conflicting conflicting JJ cord-328289-3h3kmjlz 17 22 observations observation NNS cord-328289-3h3kmjlz 17 23 , , , cord-328289-3h3kmjlz 17 24 partly partly RB cord-328289-3h3kmjlz 17 25 reflecting reflect VBG cord-328289-3h3kmjlz 17 26 the the DT cord-328289-3h3kmjlz 17 27 preliminary preliminary JJ cord-328289-3h3kmjlz 17 28 and and CC cord-328289-3h3kmjlz 17 29 incomplete incomplete JJ cord-328289-3h3kmjlz 17 30 nature nature NN cord-328289-3h3kmjlz 17 31 of of IN cord-328289-3h3kmjlz 17 32 the the DT cord-328289-3h3kmjlz 17 33 available available JJ cord-328289-3h3kmjlz 17 34 data datum NNS cord-328289-3h3kmjlz 17 35 . . . cord-328289-3h3kmjlz 18 1 Here here RB cord-328289-3h3kmjlz 18 2 , , , cord-328289-3h3kmjlz 18 3 we -PRON- PRP cord-328289-3h3kmjlz 18 4 provide provide VBP cord-328289-3h3kmjlz 18 5 a a DT cord-328289-3h3kmjlz 18 6 succinct succinct JJ cord-328289-3h3kmjlz 18 7 summary summary NN cord-328289-3h3kmjlz 18 8 of of IN cord-328289-3h3kmjlz 18 9 the the DT cord-328289-3h3kmjlz 18 10 nervous nervous JJ cord-328289-3h3kmjlz 18 11 system system NN cord-328289-3h3kmjlz 18 12 involvement involvement NN cord-328289-3h3kmjlz 18 13 in in IN cord-328289-3h3kmjlz 18 14 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 18 15 . . . cord-328289-3h3kmjlz 19 1 In in IN cord-328289-3h3kmjlz 19 2 particular particular JJ cord-328289-3h3kmjlz 19 3 , , , cord-328289-3h3kmjlz 19 4 we -PRON- PRP cord-328289-3h3kmjlz 19 5 will will MD cord-328289-3h3kmjlz 19 6 focus focus VB cord-328289-3h3kmjlz 19 7 on on IN cord-328289-3h3kmjlz 19 8 the the DT cord-328289-3h3kmjlz 19 9 mechanisms mechanism NNS cord-328289-3h3kmjlz 19 10 of of IN cord-328289-3h3kmjlz 19 11 pathogenicity pathogenicity NN cord-328289-3h3kmjlz 19 12 , , , cord-328289-3h3kmjlz 19 13 on on IN cord-328289-3h3kmjlz 19 14 the the DT cord-328289-3h3kmjlz 19 15 acute acute JJ cord-328289-3h3kmjlz 19 16 and and CC cord-328289-3h3kmjlz 19 17 delayed delayed JJ cord-328289-3h3kmjlz 19 18 neurological neurological JJ cord-328289-3h3kmjlz 19 19 manifestations manifestation NNS cord-328289-3h3kmjlz 19 20 reported report VBN cord-328289-3h3kmjlz 19 21 to to IN cord-328289-3h3kmjlz 19 22 date date NN cord-328289-3h3kmjlz 19 23 , , , cord-328289-3h3kmjlz 19 24 and and CC cord-328289-3h3kmjlz 19 25 on on IN cord-328289-3h3kmjlz 19 26 how how WRB cord-328289-3h3kmjlz 19 27 the the DT cord-328289-3h3kmjlz 19 28 nervous nervous JJ cord-328289-3h3kmjlz 19 29 system system NN cord-328289-3h3kmjlz 19 30 involvement involvement NN cord-328289-3h3kmjlz 19 31 compares compare VBZ cord-328289-3h3kmjlz 19 32 to to IN cord-328289-3h3kmjlz 19 33 that that DT cord-328289-3h3kmjlz 19 34 of of IN cord-328289-3h3kmjlz 19 35 other other JJ cord-328289-3h3kmjlz 19 36 respiratory respiratory JJ cord-328289-3h3kmjlz 19 37 viruses virus NNS cord-328289-3h3kmjlz 19 38 . . . cord-328289-3h3kmjlz 20 1 Finally finally RB cord-328289-3h3kmjlz 20 2 , , , cord-328289-3h3kmjlz 20 3 we -PRON- PRP cord-328289-3h3kmjlz 20 4 will will MD cord-328289-3h3kmjlz 20 5 attempt attempt VB cord-328289-3h3kmjlz 20 6 to to IN cord-328289-3h3kmjlz 20 7 flesh flesh NN cord-328289-3h3kmjlz 20 8 out out RP cord-328289-3h3kmjlz 20 9 caveats caveat NNS cord-328289-3h3kmjlz 20 10 and and CC cord-328289-3h3kmjlz 20 11 unanswered unanswered JJ cord-328289-3h3kmjlz 20 12 questions question NNS cord-328289-3h3kmjlz 20 13 that that WDT cord-328289-3h3kmjlz 20 14 may may MD cord-328289-3h3kmjlz 20 15 help help VB cord-328289-3h3kmjlz 20 16 gain gain VB cord-328289-3h3kmjlz 20 17 a a DT cord-328289-3h3kmjlz 20 18 better well JJR cord-328289-3h3kmjlz 20 19 appreciation appreciation NN cord-328289-3h3kmjlz 20 20 of of IN cord-328289-3h3kmjlz 20 21 this this DT cord-328289-3h3kmjlz 20 22 critical critical JJ cord-328289-3h3kmjlz 20 23 aspect aspect NN cord-328289-3h3kmjlz 20 24 of of IN cord-328289-3h3kmjlz 20 25 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 20 26 and and CC cord-328289-3h3kmjlz 20 27 chart chart VB cord-328289-3h3kmjlz 20 28 a a DT cord-328289-3h3kmjlz 20 29 path path NN cord-328289-3h3kmjlz 20 30 forward forward RB cord-328289-3h3kmjlz 20 31 to to TO cord-328289-3h3kmjlz 20 32 minimize minimize VB cord-328289-3h3kmjlz 20 33 its -PRON- PRP$ cord-328289-3h3kmjlz 20 34 harmful harmful JJ cord-328289-3h3kmjlz 20 35 nervous nervous JJ cord-328289-3h3kmjlz 20 36 system system NN cord-328289-3h3kmjlz 20 37 involvement involvement NN cord-328289-3h3kmjlz 20 38 . . . cord-328289-3h3kmjlz 21 1 an an DT cord-328289-3h3kmjlz 21 2 ACE2-dependent ACE2-dependent NNP cord-328289-3h3kmjlz 21 3 manner manner NN cord-328289-3h3kmjlz 21 4 ( ( -LRB- cord-328289-3h3kmjlz 21 5 Song Song NNP cord-328289-3h3kmjlz 21 6 et et FW cord-328289-3h3kmjlz 21 7 al al NNP cord-328289-3h3kmjlz 21 8 . . NNP cord-328289-3h3kmjlz 21 9 , , , cord-328289-3h3kmjlz 21 10 2020 2020 CD cord-328289-3h3kmjlz 21 11 ) ) -RRB- cord-328289-3h3kmjlz 21 12 . . . cord-328289-3h3kmjlz 22 1 In in IN cord-328289-3h3kmjlz 22 2 brain brain NN cord-328289-3h3kmjlz 22 3 cells cell NNS cord-328289-3h3kmjlz 22 4 derived derive VBN cord-328289-3h3kmjlz 22 5 from from IN cord-328289-3h3kmjlz 22 6 human human JJ cord-328289-3h3kmjlz 22 7 pluripotent pluripotent JJ cord-328289-3h3kmjlz 22 8 stem stem NN cord-328289-3h3kmjlz 22 9 cells cell NNS cord-328289-3h3kmjlz 22 10 , , , cord-328289-3h3kmjlz 22 11 dopaminergic dopaminergic JJ cord-328289-3h3kmjlz 22 12 neurons neuron NNS cord-328289-3h3kmjlz 22 13 , , , cord-328289-3h3kmjlz 22 14 but but CC cord-328289-3h3kmjlz 22 15 not not RB cord-328289-3h3kmjlz 22 16 cortical cortical JJ cord-328289-3h3kmjlz 22 17 neurons neuron NNS cord-328289-3h3kmjlz 22 18 or or CC cord-328289-3h3kmjlz 22 19 microglia microglia NNS cord-328289-3h3kmjlz 22 20 , , , cord-328289-3h3kmjlz 22 21 were be VBD cord-328289-3h3kmjlz 22 22 particularly particularly RB cord-328289-3h3kmjlz 22 23 susceptible susceptible JJ cord-328289-3h3kmjlz 22 24 to to IN cord-328289-3h3kmjlz 22 25 SARS SARS NNP cord-328289-3h3kmjlz 22 26 - - HYPH cord-328289-3h3kmjlz 22 27 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 22 28 infection infection NN cord-328289-3h3kmjlz 22 29 . . . cord-328289-3h3kmjlz 23 1 Clinical clinical JJ cord-328289-3h3kmjlz 23 2 - - HYPH cord-328289-3h3kmjlz 23 3 pathological pathological JJ cord-328289-3h3kmjlz 23 4 studies study NNS cord-328289-3h3kmjlz 23 5 that that WDT cord-328289-3h3kmjlz 23 6 have have VBP cord-328289-3h3kmjlz 23 7 tested test VBN cord-328289-3h3kmjlz 23 8 for for IN cord-328289-3h3kmjlz 23 9 the the DT cord-328289-3h3kmjlz 23 10 presence presence NN cord-328289-3h3kmjlz 23 11 of of IN cord-328289-3h3kmjlz 23 12 the the DT cord-328289-3h3kmjlz 23 13 virus virus NN cord-328289-3h3kmjlz 23 14 in in IN cord-328289-3h3kmjlz 23 15 the the DT cord-328289-3h3kmjlz 23 16 brain brain NN cord-328289-3h3kmjlz 23 17 or or CC cord-328289-3h3kmjlz 23 18 the the DT cord-328289-3h3kmjlz 23 19 cerebrospinal cerebrospinal JJ cord-328289-3h3kmjlz 23 20 fluid fluid NN cord-328289-3h3kmjlz 23 21 ( ( -LRB- cord-328289-3h3kmjlz 23 22 CSF CSF NNP cord-328289-3h3kmjlz 23 23 ) ) -RRB- cord-328289-3h3kmjlz 23 24 have have VBP cord-328289-3h3kmjlz 23 25 had have VBN cord-328289-3h3kmjlz 23 26 mixed mix VBN cord-328289-3h3kmjlz 23 27 results result NNS cord-328289-3h3kmjlz 23 28 . . . cord-328289-3h3kmjlz 24 1 Some some DT cord-328289-3h3kmjlz 24 2 studies study NNS cord-328289-3h3kmjlz 24 3 have have VBP cord-328289-3h3kmjlz 24 4 shown show VBN cord-328289-3h3kmjlz 24 5 SARS SARS NNP cord-328289-3h3kmjlz 24 6 - - HYPH cord-328289-3h3kmjlz 24 7 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 24 8 RNA RNA NNP cord-328289-3h3kmjlz 24 9 in in IN cord-328289-3h3kmjlz 24 10 brain brain NN cord-328289-3h3kmjlz 24 11 post post NN cord-328289-3h3kmjlz 24 12 - - JJ cord-328289-3h3kmjlz 24 13 mortem mortem JJ cord-328289-3h3kmjlz 24 14 or or CC cord-328289-3h3kmjlz 24 15 in in IN cord-328289-3h3kmjlz 24 16 the the DT cord-328289-3h3kmjlz 24 17 CSF CSF NNP cord-328289-3h3kmjlz 24 18 in in IN cord-328289-3h3kmjlz 24 19 patients patient NNS cord-328289-3h3kmjlz 24 20 with with IN cord-328289-3h3kmjlz 24 21 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 24 22 or or CC cord-328289-3h3kmjlz 24 23 encephalitis encephalitis JJ cord-328289-3h3kmjlz 24 24 , , , cord-328289-3h3kmjlz 24 25 but but CC cord-328289-3h3kmjlz 24 26 at at IN cord-328289-3h3kmjlz 24 27 very very RB cord-328289-3h3kmjlz 24 28 low low JJ cord-328289-3h3kmjlz 24 29 levels level NNS cord-328289-3h3kmjlz 24 30 ( ( -LRB- cord-328289-3h3kmjlz 24 31 Moriguchi Moriguchi NNP cord-328289-3h3kmjlz 24 32 et et NNP cord-328289-3h3kmjlz 24 33 al al NNP cord-328289-3h3kmjlz 24 34 . . NNP cord-328289-3h3kmjlz 24 35 , , , cord-328289-3h3kmjlz 24 36 2020 2020 CD cord-328289-3h3kmjlz 24 37 ; ; : cord-328289-3h3kmjlz 24 38 Solomon Solomon NNP cord-328289-3h3kmjlz 24 39 et et NNP cord-328289-3h3kmjlz 24 40 al al NNP cord-328289-3h3kmjlz 24 41 . . NNP cord-328289-3h3kmjlz 24 42 , , , cord-328289-3h3kmjlz 24 43 2020 2020 CD cord-328289-3h3kmjlz 24 44 ) ) -RRB- cord-328289-3h3kmjlz 24 45 . . . cord-328289-3h3kmjlz 25 1 Other other JJ cord-328289-3h3kmjlz 25 2 studies study NNS cord-328289-3h3kmjlz 25 3 could could MD cord-328289-3h3kmjlz 25 4 not not RB cord-328289-3h3kmjlz 25 5 detect detect VB cord-328289-3h3kmjlz 25 6 viral viral JJ cord-328289-3h3kmjlz 25 7 invasion invasion NN cord-328289-3h3kmjlz 25 8 , , , cord-328289-3h3kmjlz 25 9 even even RB cord-328289-3h3kmjlz 25 10 though though IN cord-328289-3h3kmjlz 25 11 there there EX cord-328289-3h3kmjlz 25 12 was be VBD cord-328289-3h3kmjlz 25 13 evidence evidence NN cord-328289-3h3kmjlz 25 14 of of IN cord-328289-3h3kmjlz 25 15 CSF CSF NNP cord-328289-3h3kmjlz 25 16 inflammation inflammation NN cord-328289-3h3kmjlz 25 17 ( ( -LRB- cord-328289-3h3kmjlz 25 18 Bernard Bernard NNP cord-328289-3h3kmjlz 25 19 - - HYPH cord-328289-3h3kmjlz 25 20 Valnet Valnet NNP cord-328289-3h3kmjlz 25 21 et et NNP cord-328289-3h3kmjlz 25 22 al al NNP cord-328289-3h3kmjlz 25 23 . . NNP cord-328289-3h3kmjlz 25 24 , , , cord-328289-3h3kmjlz 25 25 2020 2020 CD cord-328289-3h3kmjlz 25 26 ; ; : cord-328289-3h3kmjlz 25 27 Ye Ye NNP cord-328289-3h3kmjlz 25 28 et et NNP cord-328289-3h3kmjlz 25 29 al al NNP cord-328289-3h3kmjlz 25 30 . . NNP cord-328289-3h3kmjlz 25 31 , , , cord-328289-3h3kmjlz 25 32 2020 2020 CD cord-328289-3h3kmjlz 25 33 ) ) -RRB- cord-328289-3h3kmjlz 25 34 . . . cord-328289-3h3kmjlz 26 1 Considering consider VBG cord-328289-3h3kmjlz 26 2 the the DT cord-328289-3h3kmjlz 26 3 inconsistent inconsistent JJ cord-328289-3h3kmjlz 26 4 data datum NNS cord-328289-3h3kmjlz 26 5 and and CC cord-328289-3h3kmjlz 26 6 the the DT cord-328289-3h3kmjlz 26 7 low low JJ cord-328289-3h3kmjlz 26 8 levels level NNS cord-328289-3h3kmjlz 26 9 of of IN cord-328289-3h3kmjlz 26 10 viral viral JJ cord-328289-3h3kmjlz 26 11 RNA RNA NNP cord-328289-3h3kmjlz 26 12 , , , cord-328289-3h3kmjlz 26 13 when when WRB cord-328289-3h3kmjlz 26 14 detected detect VBN cord-328289-3h3kmjlz 26 15 , , , cord-328289-3h3kmjlz 26 16 the the DT cord-328289-3h3kmjlz 26 17 possibility possibility NN cord-328289-3h3kmjlz 26 18 of of IN cord-328289-3h3kmjlz 26 19 artifact artifact NN cord-328289-3h3kmjlz 26 20 or or CC cord-328289-3h3kmjlz 26 21 contamination contamination NN cord-328289-3h3kmjlz 26 22 has have VBZ cord-328289-3h3kmjlz 26 23 been be VBN cord-328289-3h3kmjlz 26 24 raised raise VBN cord-328289-3h3kmjlz 26 25 ( ( -LRB- cord-328289-3h3kmjlz 26 26 Solomon Solomon NNP cord-328289-3h3kmjlz 26 27 et et NNP cord-328289-3h3kmjlz 26 28 al al NNP cord-328289-3h3kmjlz 26 29 . . NNP cord-328289-3h3kmjlz 26 30 , , , cord-328289-3h3kmjlz 26 31 2020 2020 CD cord-328289-3h3kmjlz 26 32 ) ) -RRB- cord-328289-3h3kmjlz 26 33 . . . cord-328289-3h3kmjlz 27 1 Potential potential JJ cord-328289-3h3kmjlz 27 2 Routes route NNS cord-328289-3h3kmjlz 27 3 of of IN cord-328289-3h3kmjlz 27 4 brain brain NN cord-328289-3h3kmjlz 27 5 entry entry NN cord-328289-3h3kmjlz 27 6 : : : cord-328289-3h3kmjlz 27 7 Examination examination NN cord-328289-3h3kmjlz 27 8 of of IN cord-328289-3h3kmjlz 27 9 how how WRB cord-328289-3h3kmjlz 27 10 the the DT cord-328289-3h3kmjlz 27 11 virus virus NN cord-328289-3h3kmjlz 27 12 could could MD cord-328289-3h3kmjlz 27 13 enter enter VB cord-328289-3h3kmjlz 27 14 the the DT cord-328289-3h3kmjlz 27 15 nervous nervous JJ cord-328289-3h3kmjlz 27 16 system system NN cord-328289-3h3kmjlz 27 17 may may MD cord-328289-3h3kmjlz 27 18 help help VB cord-328289-3h3kmjlz 27 19 assess assess VB cord-328289-3h3kmjlz 27 20 the the DT cord-328289-3h3kmjlz 27 21 likelihood likelihood NN cord-328289-3h3kmjlz 27 22 for for IN cord-328289-3h3kmjlz 27 23 direct direct JJ cord-328289-3h3kmjlz 27 24 invasion invasion NN cord-328289-3h3kmjlz 27 25 and and CC cord-328289-3h3kmjlz 27 26 pathogenicity pathogenicity NN cord-328289-3h3kmjlz 27 27 . . . cord-328289-3h3kmjlz 28 1 Based base VBN cord-328289-3h3kmjlz 28 2 on on IN cord-328289-3h3kmjlz 28 3 other other JJ cord-328289-3h3kmjlz 28 4 coronaviruses coronaviruse NNS cord-328289-3h3kmjlz 28 5 , , , cord-328289-3h3kmjlz 28 6 several several JJ cord-328289-3h3kmjlz 28 7 potential potential JJ cord-328289-3h3kmjlz 28 8 routes route NNS cord-328289-3h3kmjlz 28 9 of of IN cord-328289-3h3kmjlz 28 10 entry entry NN cord-328289-3h3kmjlz 28 11 for for IN cord-328289-3h3kmjlz 28 12 SARS SARS NNP cord-328289-3h3kmjlz 28 13 - - HYPH cord-328289-3h3kmjlz 28 14 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 28 15 have have VBP cord-328289-3h3kmjlz 28 16 been be VBN cord-328289-3h3kmjlz 28 17 proposed propose VBN cord-328289-3h3kmjlz 28 18 ( ( -LRB- cord-328289-3h3kmjlz 28 19 Bergmann Bergmann NNP cord-328289-3h3kmjlz 28 20 et et NNP cord-328289-3h3kmjlz 28 21 al al NNP cord-328289-3h3kmjlz 28 22 . . NNP cord-328289-3h3kmjlz 28 23 , , , cord-328289-3h3kmjlz 28 24 2006 2006 CD cord-328289-3h3kmjlz 28 25 ) ) -RRB- cord-328289-3h3kmjlz 28 26 . . . cord-328289-3h3kmjlz 29 1 Olfactory olfactory JJ cord-328289-3h3kmjlz 29 2 route route NN cord-328289-3h3kmjlz 29 3 : : : cord-328289-3h3kmjlz 29 4 Infection infection NN cord-328289-3h3kmjlz 29 5 of of IN cord-328289-3h3kmjlz 29 6 olfactory olfactory JJ cord-328289-3h3kmjlz 29 7 system system NN cord-328289-3h3kmjlz 29 8 is be VBZ cord-328289-3h3kmjlz 29 9 consistent consistent JJ cord-328289-3h3kmjlz 29 10 with with IN cord-328289-3h3kmjlz 29 11 the the DT cord-328289-3h3kmjlz 29 12 observation observation NN cord-328289-3h3kmjlz 29 13 that that IN cord-328289-3h3kmjlz 29 14 loss loss NN cord-328289-3h3kmjlz 29 15 of of IN cord-328289-3h3kmjlz 29 16 smell smell NN cord-328289-3h3kmjlz 29 17 is be VBZ cord-328289-3h3kmjlz 29 18 a a DT cord-328289-3h3kmjlz 29 19 frequent frequent JJ cord-328289-3h3kmjlz 29 20 neurological neurological JJ cord-328289-3h3kmjlz 29 21 manifestation manifestation NN cord-328289-3h3kmjlz 29 22 in in IN cord-328289-3h3kmjlz 29 23 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 29 24 ( ( -LRB- cord-328289-3h3kmjlz 29 25 see see VB cord-328289-3h3kmjlz 29 26 Neurological neurological JJ cord-328289-3h3kmjlz 29 27 manifestations manifestation NNS cord-328289-3h3kmjlz 29 28 of of IN cord-328289-3h3kmjlz 29 29 and and CC cord-328289-3h3kmjlz 29 30 with with IN cord-328289-3h3kmjlz 29 31 evidence evidence NN cord-328289-3h3kmjlz 29 32 of of IN cord-328289-3h3kmjlz 29 33 increased increase VBN cord-328289-3h3kmjlz 29 34 MRI MRI NNP cord-328289-3h3kmjlz 29 35 signal signal NN cord-328289-3h3kmjlz 29 36 in in IN cord-328289-3h3kmjlz 29 37 the the DT cord-328289-3h3kmjlz 29 38 olfactory olfactory JJ cord-328289-3h3kmjlz 29 39 cortex cortex NN cord-328289-3h3kmjlz 29 40 suggestive suggestive JJ cord-328289-3h3kmjlz 29 41 of of IN cord-328289-3h3kmjlz 29 42 infection infection NN cord-328289-3h3kmjlz 30 1 ( ( -LRB- cord-328289-3h3kmjlz 30 2 Politi Politi NNP cord-328289-3h3kmjlz 30 3 et et FW cord-328289-3h3kmjlz 30 4 al al NNP cord-328289-3h3kmjlz 30 5 . . NNP cord-328289-3h3kmjlz 30 6 , , , cord-328289-3h3kmjlz 30 7 2020 2020 CD cord-328289-3h3kmjlz 30 8 ) ) -RRB- cord-328289-3h3kmjlz 30 9 . . . cord-328289-3h3kmjlz 31 1 The the DT cord-328289-3h3kmjlz 31 2 virus virus NN cord-328289-3h3kmjlz 31 3 could could MD cord-328289-3h3kmjlz 31 4 be be VB cord-328289-3h3kmjlz 31 5 internalized internalize VBN cord-328289-3h3kmjlz 31 6 in in IN cord-328289-3h3kmjlz 31 7 nerve nerve NN cord-328289-3h3kmjlz 31 8 terminals terminal NNS cord-328289-3h3kmjlz 31 9 by by IN cord-328289-3h3kmjlz 31 10 endocytosis endocytosis NN cord-328289-3h3kmjlz 31 11 , , , cord-328289-3h3kmjlz 31 12 transported transport VBN cord-328289-3h3kmjlz 31 13 retrogradely retrogradely RB cord-328289-3h3kmjlz 31 14 , , , cord-328289-3h3kmjlz 31 15 and and CC cord-328289-3h3kmjlz 31 16 spread spread VB cord-328289-3h3kmjlz 31 17 trans trans NNP cord-328289-3h3kmjlz 31 18 - - NN cord-328289-3h3kmjlz 31 19 synaptically synaptically RB cord-328289-3h3kmjlz 31 20 to to IN cord-328289-3h3kmjlz 31 21 other other JJ cord-328289-3h3kmjlz 31 22 brain brain NN cord-328289-3h3kmjlz 31 23 regions region NNS cord-328289-3h3kmjlz 31 24 , , , cord-328289-3h3kmjlz 31 25 as as IN cord-328289-3h3kmjlz 31 26 described describe VBN cord-328289-3h3kmjlz 31 27 for for IN cord-328289-3h3kmjlz 31 28 other other JJ cord-328289-3h3kmjlz 31 29 coronaviruses coronaviruse NNS cord-328289-3h3kmjlz 31 30 ( ( -LRB- cord-328289-3h3kmjlz 31 31 Dubé Dubé NNP cord-328289-3h3kmjlz 31 32 et et FW cord-328289-3h3kmjlz 31 33 al al NNP cord-328289-3h3kmjlz 31 34 . . NNP cord-328289-3h3kmjlz 31 35 , , , cord-328289-3h3kmjlz 31 36 2018 2018 CD cord-328289-3h3kmjlz 31 37 ) ) -RRB- cord-328289-3h3kmjlz 31 38 . . . cord-328289-3h3kmjlz 32 1 ACE2 ACE2 NNP cord-328289-3h3kmjlz 32 2 and and CC cord-328289-3h3kmjlz 32 3 TMPRSS2 TMPRSS2 NNP cord-328289-3h3kmjlz 32 4 have have VBP cord-328289-3h3kmjlz 32 5 been be VBN cord-328289-3h3kmjlz 32 6 detected detect VBN cord-328289-3h3kmjlz 32 7 in in IN cord-328289-3h3kmjlz 32 8 the the DT cord-328289-3h3kmjlz 32 9 nasal nasal NN cord-328289-3h3kmjlz 32 10 mucosa mucosa JJ cord-328289-3h3kmjlz 32 11 at at IN cord-328289-3h3kmjlz 32 12 the the DT cord-328289-3h3kmjlz 32 13 RNA RNA NNP cord-328289-3h3kmjlz 32 14 and and CC cord-328289-3h3kmjlz 32 15 protein protein NN cord-328289-3h3kmjlz 32 16 levels level NNS cord-328289-3h3kmjlz 32 17 , , , cord-328289-3h3kmjlz 32 18 but but CC cord-328289-3h3kmjlz 32 19 they -PRON- PRP cord-328289-3h3kmjlz 32 20 seem seem VBP cord-328289-3h3kmjlz 32 21 to to TO cord-328289-3h3kmjlz 32 22 be be VB cord-328289-3h3kmjlz 32 23 localized localize VBN cord-328289-3h3kmjlz 32 24 to to IN cord-328289-3h3kmjlz 32 25 epithelial epithelial JJ cord-328289-3h3kmjlz 32 26 cells cell NNS cord-328289-3h3kmjlz 32 27 ( ( -LRB- cord-328289-3h3kmjlz 32 28 sustentacular sustentacular NNP cord-328289-3h3kmjlz 32 29 cells cell NNS cord-328289-3h3kmjlz 32 30 ) ) -RRB- cord-328289-3h3kmjlz 32 31 , , , cord-328289-3h3kmjlz 32 32 not not RB cord-328289-3h3kmjlz 32 33 olfactory olfactory JJ cord-328289-3h3kmjlz 32 34 neurons neuron NNS cord-328289-3h3kmjlz 32 35 ( ( -LRB- cord-328289-3h3kmjlz 32 36 Brann Brann NNP cord-328289-3h3kmjlz 32 37 et et NNP cord-328289-3h3kmjlz 32 38 al al NNP cord-328289-3h3kmjlz 32 39 . . NNP cord-328289-3h3kmjlz 32 40 , , , cord-328289-3h3kmjlz 32 41 2020 2020 CD cord-328289-3h3kmjlz 32 42 ) ) -RRB- cord-328289-3h3kmjlz 32 43 , , , cord-328289-3h3kmjlz 32 44 although although IN cord-328289-3h3kmjlz 32 45 another another DT cord-328289-3h3kmjlz 32 46 report report NN cord-328289-3h3kmjlz 32 47 suggests suggest VBZ cord-328289-3h3kmjlz 32 48 neuronal neuronal JJ cord-328289-3h3kmjlz 32 49 involvement involvement NN cord-328289-3h3kmjlz 32 50 ( ( -LRB- cord-328289-3h3kmjlz 32 51 Nampoothiri Nampoothiri NNP cord-328289-3h3kmjlz 32 52 et et NNP cord-328289-3h3kmjlz 32 53 al al NNP cord-328289-3h3kmjlz 32 54 . . NNP cord-328289-3h3kmjlz 32 55 , , , cord-328289-3h3kmjlz 32 56 2020 2020 CD cord-328289-3h3kmjlz 32 57 ) ) -RRB- cord-328289-3h3kmjlz 32 58 . . . cord-328289-3h3kmjlz 33 1 Therefore therefore RB cord-328289-3h3kmjlz 33 2 , , , cord-328289-3h3kmjlz 33 3 it -PRON- PRP cord-328289-3h3kmjlz 33 4 is be VBZ cord-328289-3h3kmjlz 33 5 unclear unclear JJ cord-328289-3h3kmjlz 33 6 if if IN cord-328289-3h3kmjlz 33 7 the the DT cord-328289-3h3kmjlz 33 8 virus virus NN cord-328289-3h3kmjlz 33 9 is be VBZ cord-328289-3h3kmjlz 33 10 restricted restrict VBN cord-328289-3h3kmjlz 33 11 to to IN cord-328289-3h3kmjlz 33 12 the the DT cord-328289-3h3kmjlz 33 13 olfactory olfactory JJ cord-328289-3h3kmjlz 33 14 epithelium epithelium NN cord-328289-3h3kmjlz 33 15 or or CC cord-328289-3h3kmjlz 33 16 reaches reach VBZ cord-328289-3h3kmjlz 33 17 olfactory olfactory JJ cord-328289-3h3kmjlz 33 18 neurons neuron NNS cord-328289-3h3kmjlz 33 19 . . . cord-328289-3h3kmjlz 34 1 Blood blood NN cord-328289-3h3kmjlz 34 2 - - HYPH cord-328289-3h3kmjlz 34 3 brain brain NN cord-328289-3h3kmjlz 34 4 barrier barrier NN cord-328289-3h3kmjlz 34 5 : : : cord-328289-3h3kmjlz 34 6 The the DT cord-328289-3h3kmjlz 34 7 BBB BBB NNP cord-328289-3h3kmjlz 34 8 is be VBZ cord-328289-3h3kmjlz 34 9 a a DT cord-328289-3h3kmjlz 34 10 common common JJ cord-328289-3h3kmjlz 34 11 route route NN cord-328289-3h3kmjlz 34 12 of of IN cord-328289-3h3kmjlz 34 13 entry entry NN cord-328289-3h3kmjlz 34 14 of of IN cord-328289-3h3kmjlz 34 15 blood blood NN cord-328289-3h3kmjlz 34 16 - - HYPH cord-328289-3h3kmjlz 34 17 borne bear VBN cord-328289-3h3kmjlz 34 18 viruses virus NNS cord-328289-3h3kmjlz 34 19 into into IN cord-328289-3h3kmjlz 34 20 the the DT cord-328289-3h3kmjlz 34 21 brain brain NN cord-328289-3h3kmjlz 35 1 ( ( -LRB- cord-328289-3h3kmjlz 35 2 Bergmann Bergmann NNP cord-328289-3h3kmjlz 35 3 et et NNP cord-328289-3h3kmjlz 35 4 al al NNP cord-328289-3h3kmjlz 35 5 . . NNP cord-328289-3h3kmjlz 35 6 , , , cord-328289-3h3kmjlz 35 7 2006 2006 CD cord-328289-3h3kmjlz 35 8 ) ) -RRB- cord-328289-3h3kmjlz 35 9 . . . cord-328289-3h3kmjlz 36 1 In in IN cord-328289-3h3kmjlz 36 2 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 36 3 , , , cord-328289-3h3kmjlz 36 4 dissemination dissemination NN cord-328289-3h3kmjlz 36 5 of of IN cord-328289-3h3kmjlz 36 6 the the DT cord-328289-3h3kmjlz 36 7 virus virus NN cord-328289-3h3kmjlz 36 8 into into IN cord-328289-3h3kmjlz 36 9 the the DT cord-328289-3h3kmjlz 36 10 blood blood NN cord-328289-3h3kmjlz 36 11 has have VBZ cord-328289-3h3kmjlz 36 12 been be VBN cord-328289-3h3kmjlz 36 13 described describe VBN cord-328289-3h3kmjlz 36 14 , , , cord-328289-3h3kmjlz 36 15 albeit albeit IN cord-328289-3h3kmjlz 36 16 with with IN cord-328289-3h3kmjlz 36 17 widely widely RB cord-328289-3h3kmjlz 36 18 ranging range VBG cord-328289-3h3kmjlz 36 19 frequencies frequency NNS cord-328289-3h3kmjlz 36 20 ( ( -LRB- cord-328289-3h3kmjlz 36 21 1 1 CD cord-328289-3h3kmjlz 36 22 % % NN cord-328289-3h3kmjlz 36 23 to to IN cord-328289-3h3kmjlz 36 24 41 41 CD cord-328289-3h3kmjlz 36 25 % % NN cord-328289-3h3kmjlz 36 26 ) ) -RRB- cord-328289-3h3kmjlz 37 1 ( ( -LRB- cord-328289-3h3kmjlz 37 2 Wang Wang NNP cord-328289-3h3kmjlz 37 3 et et NNP cord-328289-3h3kmjlz 37 4 al al NNP cord-328289-3h3kmjlz 37 5 . . NNP cord-328289-3h3kmjlz 37 6 , , , cord-328289-3h3kmjlz 37 7 2020c 2020c CD cord-328289-3h3kmjlz 37 8 ; ; : cord-328289-3h3kmjlz 37 9 Zheng Zheng NNP cord-328289-3h3kmjlz 37 10 et et NNP cord-328289-3h3kmjlz 37 11 al al NNP cord-328289-3h3kmjlz 37 12 . . NNP cord-328289-3h3kmjlz 37 13 , , , cord-328289-3h3kmjlz 37 14 2020 2020 CD cord-328289-3h3kmjlz 37 15 ) ) -RRB- cord-328289-3h3kmjlz 37 16 , , , cord-328289-3h3kmjlz 37 17 and and CC cord-328289-3h3kmjlz 37 18 the the DT cord-328289-3h3kmjlz 37 19 virus virus NN cord-328289-3h3kmjlz 37 20 could could MD cord-328289-3h3kmjlz 37 21 access access VB cord-328289-3h3kmjlz 37 22 the the DT cord-328289-3h3kmjlz 37 23 brain brain NN cord-328289-3h3kmjlz 37 24 by by IN cord-328289-3h3kmjlz 37 25 crossing cross VBG cord-328289-3h3kmjlz 37 26 the the DT cord-328289-3h3kmjlz 37 27 BBB BBB NNP cord-328289-3h3kmjlz 37 28 . . . cord-328289-3h3kmjlz 38 1 Crossing cross VBG cord-328289-3h3kmjlz 38 2 the the DT cord-328289-3h3kmjlz 38 3 intact intact JJ cord-328289-3h3kmjlz 38 4 BBB BBB NNP cord-328289-3h3kmjlz 38 5 would would MD cord-328289-3h3kmjlz 38 6 require require VB cord-328289-3h3kmjlz 38 7 internalization internalization NN cord-328289-3h3kmjlz 38 8 and and CC cord-328289-3h3kmjlz 38 9 transport transport NN cord-328289-3h3kmjlz 38 10 of of IN cord-328289-3h3kmjlz 38 11 the the DT cord-328289-3h3kmjlz 38 12 virus virus NN cord-328289-3h3kmjlz 38 13 across across IN cord-328289-3h3kmjlz 38 14 the the DT cord-328289-3h3kmjlz 38 15 cerebral cerebral JJ cord-328289-3h3kmjlz 38 16 endothelium endothelium NN cord-328289-3h3kmjlz 38 17 , , , cord-328289-3h3kmjlz 38 18 in in IN cord-328289-3h3kmjlz 38 19 which which WDT cord-328289-3h3kmjlz 38 20 the the DT cord-328289-3h3kmjlz 38 21 expression expression NN cord-328289-3h3kmjlz 38 22 of of IN cord-328289-3h3kmjlz 38 23 SARS SARS NNP cord-328289-3h3kmjlz 38 24 - - HYPH cord-328289-3h3kmjlz 38 25 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 38 26 docking docking NN cord-328289-3h3kmjlz 38 27 proteins protein NNS cord-328289-3h3kmjlz 38 28 remains remain VBZ cord-328289-3h3kmjlz 38 29 unclear unclear JJ cord-328289-3h3kmjlz 38 30 ( ( -LRB- cord-328289-3h3kmjlz 38 31 Figure figure NN cord-328289-3h3kmjlz 38 32 1 1 CD cord-328289-3h3kmjlz 38 33 ) ) -RRB- cord-328289-3h3kmjlz 38 34 . . . cord-328289-3h3kmjlz 39 1 ACE2 ACE2 NNP cord-328289-3h3kmjlz 39 2 immunoreactivity immunoreactivity NN cord-328289-3h3kmjlz 39 3 was be VBD cord-328289-3h3kmjlz 39 4 observed observe VBN cord-328289-3h3kmjlz 39 5 in in IN cord-328289-3h3kmjlz 39 6 brain brain NN cord-328289-3h3kmjlz 39 7 vessels vessel NNS cord-328289-3h3kmjlz 39 8 of of IN cord-328289-3h3kmjlz 39 9 a a DT cord-328289-3h3kmjlz 39 10 patient patient NN cord-328289-3h3kmjlz 39 11 who who WP cord-328289-3h3kmjlz 39 12 died die VBD cord-328289-3h3kmjlz 39 13 with with IN cord-328289-3h3kmjlz 39 14 multiple multiple JJ cord-328289-3h3kmjlz 39 15 ischemic ischemic JJ cord-328289-3h3kmjlz 39 16 infarcts infarct NNS cord-328289-3h3kmjlz 39 17 but but CC cord-328289-3h3kmjlz 39 18 the the DT cord-328289-3h3kmjlz 39 19 cellular cellular JJ cord-328289-3h3kmjlz 39 20 localization localization NN cord-328289-3h3kmjlz 39 21 was be VBD cord-328289-3h3kmjlz 39 22 not not RB cord-328289-3h3kmjlz 39 23 determined determine VBN cord-328289-3h3kmjlz 39 24 ( ( -LRB- cord-328289-3h3kmjlz 39 25 Bryce Bryce NNP cord-328289-3h3kmjlz 39 26 et et NNP cord-328289-3h3kmjlz 39 27 al al NNP cord-328289-3h3kmjlz 39 28 . . NNP cord-328289-3h3kmjlz 39 29 , , , cord-328289-3h3kmjlz 39 30 2020 2020 CD cord-328289-3h3kmjlz 39 31 ) ) -RRB- cord-328289-3h3kmjlz 39 32 . . . cord-328289-3h3kmjlz 40 1 The the DT cord-328289-3h3kmjlz 40 2 possibility possibility NN cord-328289-3h3kmjlz 40 3 of of IN cord-328289-3h3kmjlz 40 4 entry entry NN cord-328289-3h3kmjlz 40 5 through through IN cord-328289-3h3kmjlz 40 6 other other JJ cord-328289-3h3kmjlz 40 7 putative putative JJ cord-328289-3h3kmjlz 40 8 SARS SARS NNP cord-328289-3h3kmjlz 40 9 - - HYPH cord-328289-3h3kmjlz 40 10 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 40 11 receptors receptor NNS cord-328289-3h3kmjlz 40 12 expressed express VBD cord-328289-3h3kmjlz 40 13 more more RBR cord-328289-3h3kmjlz 40 14 widely widely RB cord-328289-3h3kmjlz 40 15 in in IN cord-328289-3h3kmjlz 40 16 the the DT cord-328289-3h3kmjlz 40 17 cerebral cerebral JJ cord-328289-3h3kmjlz 40 18 vasculature vasculature NN cord-328289-3h3kmjlz 40 19 , , , cord-328289-3h3kmjlz 40 20 such such JJ cord-328289-3h3kmjlz 40 21 as as IN cord-328289-3h3kmjlz 40 22 NRP1 NRP1 NNP cord-328289-3h3kmjlz 40 23 and and CC cord-328289-3h3kmjlz 40 24 BSG BSG NNP cord-328289-3h3kmjlz 40 25 , , , cord-328289-3h3kmjlz 40 26 can can MD cord-328289-3h3kmjlz 40 27 not not RB cord-328289-3h3kmjlz 40 28 be be VB cord-328289-3h3kmjlz 40 29 ruled rule VBN cord-328289-3h3kmjlz 40 30 out out RP cord-328289-3h3kmjlz 40 31 ( ( -LRB- cord-328289-3h3kmjlz 41 1 Cantuti Cantuti NNP cord-328289-3h3kmjlz 41 2 - - HYPH cord-328289-3h3kmjlz 41 3 Castelvetri Castelvetri NNP cord-328289-3h3kmjlz 41 4 et et FW cord-328289-3h3kmjlz 41 5 al al NNP cord-328289-3h3kmjlz 41 6 . . NNP cord-328289-3h3kmjlz 41 7 , , , cord-328289-3h3kmjlz 41 8 2020 2020 CD cord-328289-3h3kmjlz 41 9 ) ) -RRB- cord-328289-3h3kmjlz 41 10 . . . cord-328289-3h3kmjlz 42 1 On on IN cord-328289-3h3kmjlz 42 2 the the DT cord-328289-3h3kmjlz 42 3 other other JJ cord-328289-3h3kmjlz 42 4 hand hand NN cord-328289-3h3kmjlz 42 5 , , , cord-328289-3h3kmjlz 42 6 SARS SARS NNP cord-328289-3h3kmjlz 42 7 - - HYPH cord-328289-3h3kmjlz 42 8 CoV-2-associated cov-2-associate VBN cord-328289-3h3kmjlz 42 9 cytokines cytokine NNS cord-328289-3h3kmjlz 42 10 , , , cord-328289-3h3kmjlz 42 11 including include VBG cord-328289-3h3kmjlz 42 12 IL-6 IL-6 NNP cord-328289-3h3kmjlz 42 13 , , , cord-328289-3h3kmjlz 42 14 IL-1β IL-1β NNP cord-328289-3h3kmjlz 42 15 , , , cord-328289-3h3kmjlz 42 16 TNF TNF NNP cord-328289-3h3kmjlz 42 17 , , , cord-328289-3h3kmjlz 42 18 and and CC cord-328289-3h3kmjlz 42 19 IL-17 IL-17 NNP cord-328289-3h3kmjlz 42 20 disrupt disrupt VB cord-328289-3h3kmjlz 42 21 the the DT cord-328289-3h3kmjlz 42 22 BBB BBB NNP cord-328289-3h3kmjlz 42 23 ( ( -LRB- cord-328289-3h3kmjlz 42 24 Erickson Erickson NNP cord-328289-3h3kmjlz 42 25 and and CC cord-328289-3h3kmjlz 42 26 Banks Banks NNP cord-328289-3h3kmjlz 42 27 , , , cord-328289-3h3kmjlz 42 28 2018 2018 CD cord-328289-3h3kmjlz 42 29 ) ) -RRB- cord-328289-3h3kmjlz 42 30 and and CC cord-328289-3h3kmjlz 42 31 could could MD cord-328289-3h3kmjlz 42 32 facilitate facilitate VB cord-328289-3h3kmjlz 42 33 the the DT cord-328289-3h3kmjlz 42 34 entry entry NN cord-328289-3h3kmjlz 42 35 of of IN cord-328289-3h3kmjlz 42 36 the the DT cord-328289-3h3kmjlz 42 37 virus virus NN cord-328289-3h3kmjlz 42 38 ( ( -LRB- cord-328289-3h3kmjlz 42 39 Figure figure NN cord-328289-3h3kmjlz 42 40 2 2 CD cord-328289-3h3kmjlz 42 41 ) ) -RRB- cord-328289-3h3kmjlz 42 42 . . . cord-328289-3h3kmjlz 43 1 SARS SARS NNP cord-328289-3h3kmjlz 43 2 - - HYPH cord-328289-3h3kmjlz 43 3 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 43 4 has have VBZ cord-328289-3h3kmjlz 43 5 been be VBN cord-328289-3h3kmjlz 43 6 postulated postulate VBN cord-328289-3h3kmjlz 43 7 to to TO cord-328289-3h3kmjlz 43 8 induce induce VB cord-328289-3h3kmjlz 43 9 endothelial endothelial JJ cord-328289-3h3kmjlz 43 10 infection infection NN cord-328289-3h3kmjlz 43 11 and and CC cord-328289-3h3kmjlz 43 12 inflammation inflammation NN cord-328289-3h3kmjlz 43 13 in in IN cord-328289-3h3kmjlz 43 14 peripheral peripheral JJ cord-328289-3h3kmjlz 43 15 vessels vessel NNS cord-328289-3h3kmjlz 44 1 ( ( -LRB- cord-328289-3h3kmjlz 44 2 Teuwen Teuwen NNP cord-328289-3h3kmjlz 44 3 et et FW cord-328289-3h3kmjlz 44 4 al al NNP cord-328289-3h3kmjlz 44 5 . . . cord-328289-3h3kmjlz 45 1 , , , cord-328289-3h3kmjlz 45 2 2020 2020 CD cord-328289-3h3kmjlz 45 3 ) ) -RRB- cord-328289-3h3kmjlz 45 4 , , , cord-328289-3h3kmjlz 45 5 but but CC cord-328289-3h3kmjlz 45 6 direct direct JJ cord-328289-3h3kmjlz 45 7 evidence evidence NN cord-328289-3h3kmjlz 45 8 in in IN cord-328289-3h3kmjlz 45 9 cerebral cerebral JJ cord-328289-3h3kmjlz 45 10 endothelial endothelial JJ cord-328289-3h3kmjlz 45 11 cells cell NNS cord-328289-3h3kmjlz 45 12 has have VBZ cord-328289-3h3kmjlz 45 13 not not RB cord-328289-3h3kmjlz 45 14 been be VBN cord-328289-3h3kmjlz 45 15 thus thus RB cord-328289-3h3kmjlz 45 16 far far RB cord-328289-3h3kmjlz 45 17 provided provide VBN cord-328289-3h3kmjlz 45 18 . . . cord-328289-3h3kmjlz 46 1 Rather rather RB cord-328289-3h3kmjlz 46 2 , , , cord-328289-3h3kmjlz 46 3 a a DT cord-328289-3h3kmjlz 46 4 lack lack NN cord-328289-3h3kmjlz 46 5 of of IN cord-328289-3h3kmjlz 46 6 florid florid JJ cord-328289-3h3kmjlz 46 7 cerebrovascular cerebrovascular JJ cord-328289-3h3kmjlz 46 8 inflammation inflammation NN cord-328289-3h3kmjlz 46 9 has have VBZ cord-328289-3h3kmjlz 46 10 been be VBN cord-328289-3h3kmjlz 46 11 noted note VBN cord-328289-3h3kmjlz 46 12 in in IN cord-328289-3h3kmjlz 46 13 several several JJ cord-328289-3h3kmjlz 46 14 autopsy autopsy JJ cord-328289-3h3kmjlz 46 15 studies study NNS cord-328289-3h3kmjlz 46 16 ( ( -LRB- cord-328289-3h3kmjlz 46 17 Bryce Bryce NNP cord-328289-3h3kmjlz 46 18 et et NNP cord-328289-3h3kmjlz 46 19 al al NNP cord-328289-3h3kmjlz 46 20 . . NNP cord-328289-3h3kmjlz 46 21 , , , cord-328289-3h3kmjlz 46 22 2020 2020 CD cord-328289-3h3kmjlz 46 23 ; ; : cord-328289-3h3kmjlz 46 24 Kantonen Kantonen NNP cord-328289-3h3kmjlz 46 25 et et NNP cord-328289-3h3kmjlz 46 26 al al NNP cord-328289-3h3kmjlz 46 27 . . NNP cord-328289-3h3kmjlz 46 28 , , , cord-328289-3h3kmjlz 46 29 2020 2020 CD cord-328289-3h3kmjlz 46 30 ; ; . cord-328289-3h3kmjlz 47 1 Reichard Reichard NNP cord-328289-3h3kmjlz 47 2 et et NNP cord-328289-3h3kmjlz 47 3 al al NNP cord-328289-3h3kmjlz 47 4 . . NNP cord-328289-3h3kmjlz 47 5 , , , cord-328289-3h3kmjlz 47 6 2020 2020 CD cord-328289-3h3kmjlz 48 1 ; ; : cord-328289-3h3kmjlz 48 2 Solomon Solomon NNP cord-328289-3h3kmjlz 48 3 et et NNP cord-328289-3h3kmjlz 48 4 al al NNP cord-328289-3h3kmjlz 48 5 . . NNP cord-328289-3h3kmjlz 48 6 , , , cord-328289-3h3kmjlz 48 7 2020 2020 CD cord-328289-3h3kmjlz 48 8 ) ) -RRB- cord-328289-3h3kmjlz 48 9 . . . cord-328289-3h3kmjlz 49 1 Comorbidities comorbiditie NNS cord-328289-3h3kmjlz 49 2 often often RB cord-328289-3h3kmjlz 49 3 seen see VBN cord-328289-3h3kmjlz 49 4 in in IN cord-328289-3h3kmjlz 49 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 49 6 , , , cord-328289-3h3kmjlz 49 7 including include VBG cord-328289-3h3kmjlz 49 8 cardiovascular cardiovascular JJ cord-328289-3h3kmjlz 49 9 risk risk NN cord-328289-3h3kmjlz 49 10 factor factor NN cord-328289-3h3kmjlz 49 11 or or CC cord-328289-3h3kmjlz 49 12 pre pre JJ cord-328289-3h3kmjlz 49 13 - - JJ cord-328289-3h3kmjlz 49 14 existing existing JJ cord-328289-3h3kmjlz 49 15 neurological neurological JJ cord-328289-3h3kmjlz 49 16 diseases disease NNS cord-328289-3h3kmjlz 49 17 , , , cord-328289-3h3kmjlz 49 18 could could MD cord-328289-3h3kmjlz 49 19 , , , cord-328289-3h3kmjlz 49 20 alone alone RB cord-328289-3h3kmjlz 49 21 or or CC cord-328289-3h3kmjlz 49 22 in in IN cord-328289-3h3kmjlz 49 23 combination combination NN cord-328289-3h3kmjlz 49 24 with with IN cord-328289-3h3kmjlz 49 25 cytokines cytokine NNS cord-328289-3h3kmjlz 49 26 , , , cord-328289-3h3kmjlz 49 27 increase increase VB cord-328289-3h3kmjlz 49 28 BBB bbb NN cord-328289-3h3kmjlz 49 29 permeability permeability NN cord-328289-3h3kmjlz 49 30 ( ( -LRB- cord-328289-3h3kmjlz 49 31 Erickson Erickson NNP cord-328289-3h3kmjlz 49 32 and and CC cord-328289-3h3kmjlz 49 33 Banks Banks NNP cord-328289-3h3kmjlz 49 34 , , , cord-328289-3h3kmjlz 49 35 2018 2018 CD cord-328289-3h3kmjlz 49 36 ) ) -RRB- cord-328289-3h3kmjlz 49 37 . . . cord-328289-3h3kmjlz 50 1 For for IN cord-328289-3h3kmjlz 50 2 example example NN cord-328289-3h3kmjlz 50 3 , , , cord-328289-3h3kmjlz 50 4 in in IN cord-328289-3h3kmjlz 50 5 a a DT cord-328289-3h3kmjlz 50 6 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 50 7 patient patient NN cord-328289-3h3kmjlz 50 8 with with IN cord-328289-3h3kmjlz 50 9 Parkinson Parkinson NNP cord-328289-3h3kmjlz 50 10 's 's POS cord-328289-3h3kmjlz 50 11 disease disease NN cord-328289-3h3kmjlz 50 12 , , , cord-328289-3h3kmjlz 50 13 electron electron NN cord-328289-3h3kmjlz 50 14 microscopy microscopy NN cord-328289-3h3kmjlz 50 15 revealed reveal VBD cord-328289-3h3kmjlz 50 16 viral viral JJ cord-328289-3h3kmjlz 50 17 particles particle NNS cord-328289-3h3kmjlz 50 18 in in IN cord-328289-3h3kmjlz 50 19 frontal frontal JJ cord-328289-3h3kmjlz 50 20 lobe lobe NN cord-328289-3h3kmjlz 50 21 microvessels microvessel NNS cord-328289-3h3kmjlz 50 22 and and CC cord-328289-3h3kmjlz 50 23 neurons neuron NNS cord-328289-3h3kmjlz 50 24 , , , cord-328289-3h3kmjlz 50 25 suggesting suggest VBG cord-328289-3h3kmjlz 50 26 trans trans JJ cord-328289-3h3kmjlz 50 27 - - JJ cord-328289-3h3kmjlz 50 28 endothelial endothelial JJ cord-328289-3h3kmjlz 50 29 entry entry NN cord-328289-3h3kmjlz 51 1 ( ( -LRB- cord-328289-3h3kmjlz 51 2 Paniz Paniz NNP cord-328289-3h3kmjlz 51 3 - - HYPH cord-328289-3h3kmjlz 51 4 Mondolfi Mondolfi NNP cord-328289-3h3kmjlz 51 5 et et NNP cord-328289-3h3kmjlz 51 6 al al NNP cord-328289-3h3kmjlz 51 7 . . NNP cord-328289-3h3kmjlz 51 8 , , , cord-328289-3h3kmjlz 51 9 2020 2020 CD cord-328289-3h3kmjlz 51 10 ) ) -RRB- cord-328289-3h3kmjlz 51 11 . . . cord-328289-3h3kmjlz 52 1 Another another DT cord-328289-3h3kmjlz 52 2 Parkinson Parkinson NNP cord-328289-3h3kmjlz 52 3 's 's POS cord-328289-3h3kmjlz 52 4 disease disease NN cord-328289-3h3kmjlz 52 5 patient patient JJ cord-328289-3h3kmjlz 52 6 with with IN cord-328289-3h3kmjlz 52 7 obesity obesity NN cord-328289-3h3kmjlz 52 8 , , , cord-328289-3h3kmjlz 52 9 hypertension hypertension NN cord-328289-3h3kmjlz 52 10 and and CC cord-328289-3h3kmjlz 52 11 diabetes diabetes NN cord-328289-3h3kmjlz 52 12 , , , cord-328289-3h3kmjlz 52 13 exhibited exhibit VBN cord-328289-3h3kmjlz 52 14 at at IN cord-328289-3h3kmjlz 52 15 autopsy autopsy NN cord-328289-3h3kmjlz 52 16 , , , cord-328289-3h3kmjlz 52 17 in in IN cord-328289-3h3kmjlz 52 18 addition addition NN cord-328289-3h3kmjlz 52 19 to to IN cord-328289-3h3kmjlz 52 20 hypoxic hypoxic JJ cord-328289-3h3kmjlz 52 21 - - HYPH cord-328289-3h3kmjlz 52 22 ischemic ischemic JJ cord-328289-3h3kmjlz 52 23 neuronal neuronal JJ cord-328289-3h3kmjlz 52 24 damage damage NN cord-328289-3h3kmjlz 52 25 , , , cord-328289-3h3kmjlz 52 26 microhemorrhages microhemorrhages NNP cord-328289-3h3kmjlz 52 27 , , , cord-328289-3h3kmjlz 52 28 white white JJ cord-328289-3h3kmjlz 52 29 matter matter NN cord-328289-3h3kmjlz 52 30 lesions lesion NNS cord-328289-3h3kmjlz 52 31 and and CC cord-328289-3h3kmjlz 52 32 enlarged enlarged JJ cord-328289-3h3kmjlz 52 33 perivascular perivascular JJ cord-328289-3h3kmjlz 52 34 spaces space NNS cord-328289-3h3kmjlz 52 35 , , , cord-328289-3h3kmjlz 52 36 but but CC cord-328289-3h3kmjlz 52 37 no no DT cord-328289-3h3kmjlz 52 38 evidence evidence NN cord-328289-3h3kmjlz 52 39 of of IN cord-328289-3h3kmjlz 52 40 SARS SARS NNP cord-328289-3h3kmjlz 52 41 - - HYPH cord-328289-3h3kmjlz 52 42 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 52 43 in in IN cord-328289-3h3kmjlz 52 44 the the DT cord-328289-3h3kmjlz 52 45 brain brain NN cord-328289-3h3kmjlz 52 46 ( ( -LRB- cord-328289-3h3kmjlz 52 47 Kantonen Kantonen NNP cord-328289-3h3kmjlz 52 48 et et FW cord-328289-3h3kmjlz 52 49 al al NNP cord-328289-3h3kmjlz 52 50 . . NNP cord-328289-3h3kmjlz 52 51 , , , cord-328289-3h3kmjlz 52 52 2020 2020 CD cord-328289-3h3kmjlz 52 53 ) ) -RRB- cord-328289-3h3kmjlz 52 54 . . . cord-328289-3h3kmjlz 53 1 SARS SARS NNP cord-328289-3h3kmjlz 53 2 - - HYPH cord-328289-3h3kmjlz 53 3 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 53 4 could could MD cord-328289-3h3kmjlz 53 5 also also RB cord-328289-3h3kmjlz 53 6 enter enter VB cord-328289-3h3kmjlz 53 7 the the DT cord-328289-3h3kmjlz 53 8 brain brain NN cord-328289-3h3kmjlz 53 9 through through IN cord-328289-3h3kmjlz 53 10 the the DT cord-328289-3h3kmjlz 53 11 median median JJ cord-328289-3h3kmjlz 53 12 eminence eminence NN cord-328289-3h3kmjlz 53 13 of of IN cord-328289-3h3kmjlz 53 14 the the DT cord-328289-3h3kmjlz 53 15 hypothalamus hypothalamus NN cord-328289-3h3kmjlz 53 16 and and CC cord-328289-3h3kmjlz 53 17 other other JJ cord-328289-3h3kmjlz 53 18 circumventricular circumventricular JJ cord-328289-3h3kmjlz 53 19 organs organ NNS cord-328289-3h3kmjlz 53 20 , , , cord-328289-3h3kmjlz 53 21 brain brain NN cord-328289-3h3kmjlz 53 22 regions region NNS cord-328289-3h3kmjlz 53 23 with with IN cord-328289-3h3kmjlz 53 24 a a DT cord-328289-3h3kmjlz 53 25 leaky leaky JJ cord-328289-3h3kmjlz 53 26 BBB bbb NN cord-328289-3h3kmjlz 53 27 due due JJ cord-328289-3h3kmjlz 53 28 to to IN cord-328289-3h3kmjlz 53 29 openings opening NNS cord-328289-3h3kmjlz 53 30 ( ( -LRB- cord-328289-3h3kmjlz 53 31 fenestrae fenestra NNS cord-328289-3h3kmjlz 53 32 ) ) -RRB- cord-328289-3h3kmjlz 53 33 in in IN cord-328289-3h3kmjlz 53 34 the the DT cord-328289-3h3kmjlz 53 35 capillary capillary JJ cord-328289-3h3kmjlz 53 36 wall wall NN cord-328289-3h3kmjlz 53 37 ( ( -LRB- cord-328289-3h3kmjlz 53 38 Kaur Kaur NNP cord-328289-3h3kmjlz 53 39 and and CC cord-328289-3h3kmjlz 53 40 Ling Ling NNP cord-328289-3h3kmjlz 53 41 , , , cord-328289-3h3kmjlz 53 42 2017 2017 CD cord-328289-3h3kmjlz 53 43 ) ) -RRB- cord-328289-3h3kmjlz 53 44 . . . cord-328289-3h3kmjlz 54 1 Although although IN cord-328289-3h3kmjlz 54 2 the the DT cord-328289-3h3kmjlz 54 3 size size NN cord-328289-3h3kmjlz 54 4 of of IN cord-328289-3h3kmjlz 54 5 the the DT cord-328289-3h3kmjlz 54 6 viral viral JJ cord-328289-3h3kmjlz 54 7 particle particle NN cord-328289-3h3kmjlz 54 8 ( ( -LRB- cord-328289-3h3kmjlz 54 9 80 80 CD cord-328289-3h3kmjlz 54 10 - - SYM cord-328289-3h3kmjlz 54 11 120 120 CD cord-328289-3h3kmjlz 54 12 nm nm NN cord-328289-3h3kmjlz 54 13 ) ) -RRB- cord-328289-3h3kmjlz 54 14 is be VBZ cord-328289-3h3kmjlz 54 15 larger large JJR cord-328289-3h3kmjlz 54 16 than than IN cord-328289-3h3kmjlz 54 17 endothelial endothelial JJ cord-328289-3h3kmjlz 54 18 fenestrae fenestra NNS cord-328289-3h3kmjlz 54 19 ( ( -LRB- cord-328289-3h3kmjlz 54 20 Sarin Sarin NNP cord-328289-3h3kmjlz 54 21 , , , cord-328289-3h3kmjlz 54 22 2010 2010 CD cord-328289-3h3kmjlz 54 23 ) ) -RRB- cord-328289-3h3kmjlz 54 24 , , , cord-328289-3h3kmjlz 54 25 preliminary preliminary JJ cord-328289-3h3kmjlz 54 26 data datum NNS cord-328289-3h3kmjlz 54 27 suggest suggest VBP cord-328289-3h3kmjlz 54 28 J J NNP cord-328289-3h3kmjlz 54 29 o o NN cord-328289-3h3kmjlz 54 30 u u NN cord-328289-3h3kmjlz 54 31 r r NN cord-328289-3h3kmjlz 54 32 n n NN cord-328289-3h3kmjlz 54 33 a a DT cord-328289-3h3kmjlz 54 34 l l NN cord-328289-3h3kmjlz 54 35 P p NN cord-328289-3h3kmjlz 54 36 r r NN cord-328289-3h3kmjlz 54 37 e e NN cord-328289-3h3kmjlz 54 38 -p -p NN cord-328289-3h3kmjlz 55 1 r r LS cord-328289-3h3kmjlz 56 1 o o UH cord-328289-3h3kmjlz 57 1 o o UH cord-328289-3h3kmjlz 57 2 f f XX cord-328289-3h3kmjlz 57 3 that that IN cord-328289-3h3kmjlz 57 4 median median JJ cord-328289-3h3kmjlz 57 5 eminence eminence NN cord-328289-3h3kmjlz 57 6 capillaries capillary NNS cord-328289-3h3kmjlz 57 7 and and CC cord-328289-3h3kmjlz 57 8 tanycytes tanycyte NNS cord-328289-3h3kmjlz 57 9 express express VBP cord-328289-3h3kmjlz 57 10 ACE2 ACE2 NNP cord-328289-3h3kmjlz 57 11 and and CC cord-328289-3h3kmjlz 57 12 TMPRSS TMPRSS NNP cord-328289-3h3kmjlz 57 13 , , , cord-328289-3h3kmjlz 57 14 which which WDT cord-328289-3h3kmjlz 57 15 could could MD cord-328289-3h3kmjlz 57 16 allow allow VB cord-328289-3h3kmjlz 57 17 virus virus NN cord-328289-3h3kmjlz 57 18 entry entry NN cord-328289-3h3kmjlz 57 19 into into IN cord-328289-3h3kmjlz 57 20 the the DT cord-328289-3h3kmjlz 57 21 hypothalamus hypothalamus NN cord-328289-3h3kmjlz 58 1 ( ( -LRB- cord-328289-3h3kmjlz 58 2 Nampoothiri Nampoothiri NNP cord-328289-3h3kmjlz 58 3 et et NNP cord-328289-3h3kmjlz 58 4 al al NNP cord-328289-3h3kmjlz 58 5 . . NNP cord-328289-3h3kmjlz 58 6 , , , cord-328289-3h3kmjlz 58 7 2020 2020 CD cord-328289-3h3kmjlz 58 8 ) ) -RRB- cord-328289-3h3kmjlz 58 9 . . . cord-328289-3h3kmjlz 59 1 Owing owe VBG cord-328289-3h3kmjlz 59 2 to to IN cord-328289-3h3kmjlz 59 3 its -PRON- PRP$ cord-328289-3h3kmjlz 59 4 widespread widespread JJ cord-328289-3h3kmjlz 59 5 connection connection NN cord-328289-3h3kmjlz 59 6 , , , cord-328289-3h3kmjlz 59 7 the the DT cord-328289-3h3kmjlz 59 8 hypothalamus hypothalamus NN cord-328289-3h3kmjlz 59 9 could could MD cord-328289-3h3kmjlz 59 10 serve serve VB cord-328289-3h3kmjlz 59 11 as as IN cord-328289-3h3kmjlz 59 12 a a DT cord-328289-3h3kmjlz 59 13 gateway gateway NN cord-328289-3h3kmjlz 59 14 to to IN cord-328289-3h3kmjlz 59 15 the the DT cord-328289-3h3kmjlz 59 16 entire entire JJ cord-328289-3h3kmjlz 59 17 brain brain NN cord-328289-3h3kmjlz 59 18 . . . cord-328289-3h3kmjlz 60 1 Infiltration infiltration NN cord-328289-3h3kmjlz 60 2 of of IN cord-328289-3h3kmjlz 60 3 infected infected JJ cord-328289-3h3kmjlz 60 4 immune immune JJ cord-328289-3h3kmjlz 60 5 cells cell NNS cord-328289-3h3kmjlz 60 6 : : : cord-328289-3h3kmjlz 60 7 Viruses virus NNS cord-328289-3h3kmjlz 60 8 can can MD cord-328289-3h3kmjlz 60 9 enter enter VB cord-328289-3h3kmjlz 60 10 the the DT cord-328289-3h3kmjlz 60 11 brain brain NN cord-328289-3h3kmjlz 60 12 carried carry VBN cord-328289-3h3kmjlz 60 13 by by IN cord-328289-3h3kmjlz 60 14 infected infected JJ cord-328289-3h3kmjlz 60 15 immune immune JJ cord-328289-3h3kmjlz 60 16 cells cell NNS cord-328289-3h3kmjlz 60 17 , , , cord-328289-3h3kmjlz 60 18 which which WDT cord-328289-3h3kmjlz 60 19 can can MD cord-328289-3h3kmjlz 60 20 also also RB cord-328289-3h3kmjlz 60 21 serve serve VB cord-328289-3h3kmjlz 60 22 as as IN cord-328289-3h3kmjlz 60 23 reservoir reservoir NN cord-328289-3h3kmjlz 60 24 ( ( -LRB- cord-328289-3h3kmjlz 60 25 Bergmann Bergmann NNP cord-328289-3h3kmjlz 60 26 et et NNP cord-328289-3h3kmjlz 60 27 al al NNP cord-328289-3h3kmjlz 60 28 . . NNP cord-328289-3h3kmjlz 60 29 , , , cord-328289-3h3kmjlz 60 30 2006 2006 CD cord-328289-3h3kmjlz 60 31 ) ) -RRB- cord-328289-3h3kmjlz 60 32 . . . cord-328289-3h3kmjlz 61 1 Monocytes monocyte NNS cord-328289-3h3kmjlz 61 2 , , , cord-328289-3h3kmjlz 61 3 neutrophils neutrophil NNS cord-328289-3h3kmjlz 61 4 and and CC cord-328289-3h3kmjlz 61 5 Tcells Tcells NNP cord-328289-3h3kmjlz 61 6 traffic traffic NN cord-328289-3h3kmjlz 61 7 into into IN cord-328289-3h3kmjlz 61 8 the the DT cord-328289-3h3kmjlz 61 9 brain brain NN cord-328289-3h3kmjlz 61 10 through through IN cord-328289-3h3kmjlz 61 11 the the DT cord-328289-3h3kmjlz 61 12 vasculature vasculature NN cord-328289-3h3kmjlz 61 13 , , , cord-328289-3h3kmjlz 61 14 the the DT cord-328289-3h3kmjlz 61 15 meninges meninge NNS cord-328289-3h3kmjlz 61 16 and and CC cord-328289-3h3kmjlz 61 17 the the DT cord-328289-3h3kmjlz 61 18 choroid choroid JJ cord-328289-3h3kmjlz 61 19 plexus plexus NN cord-328289-3h3kmjlz 61 20 ( ( -LRB- cord-328289-3h3kmjlz 61 21 Engelhardt Engelhardt NNP cord-328289-3h3kmjlz 61 22 et et NNP cord-328289-3h3kmjlz 61 23 al al NNP cord-328289-3h3kmjlz 61 24 . . NNP cord-328289-3h3kmjlz 61 25 , , , cord-328289-3h3kmjlz 61 26 2017 2017 CD cord-328289-3h3kmjlz 61 27 ) ) -RRB- cord-328289-3h3kmjlz 61 28 , , , cord-328289-3h3kmjlz 61 29 and and CC cord-328289-3h3kmjlz 61 30 these these DT cord-328289-3h3kmjlz 61 31 sites site NNS cord-328289-3h3kmjlz 61 32 could could MD cord-328289-3h3kmjlz 61 33 be be VB cord-328289-3h3kmjlz 61 34 entry entry NN cord-328289-3h3kmjlz 61 35 points point NNS cord-328289-3h3kmjlz 61 36 for for IN cord-328289-3h3kmjlz 61 37 infected infected JJ cord-328289-3h3kmjlz 61 38 immune immune JJ cord-328289-3h3kmjlz 61 39 cells cell NNS cord-328289-3h3kmjlz 61 40 . . . cord-328289-3h3kmjlz 62 1 Conclusive conclusive JJ cord-328289-3h3kmjlz 62 2 evidence evidence NN cord-328289-3h3kmjlz 62 3 of of IN cord-328289-3h3kmjlz 62 4 infection infection NN cord-328289-3h3kmjlz 62 5 of of IN cord-328289-3h3kmjlz 62 6 immune immune JJ cord-328289-3h3kmjlz 62 7 cells cell NNS cord-328289-3h3kmjlz 62 8 by by IN cord-328289-3h3kmjlz 62 9 SARS SARS NNP cord-328289-3h3kmjlz 62 10 - - HYPH cord-328289-3h3kmjlz 62 11 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 62 12 has have VBZ cord-328289-3h3kmjlz 62 13 not not RB cord-328289-3h3kmjlz 62 14 been be VBN cord-328289-3h3kmjlz 62 15 provided provide VBN cord-328289-3h3kmjlz 62 16 thus thus RB cord-328289-3h3kmjlz 62 17 far far RB cord-328289-3h3kmjlz 63 1 ( ( -LRB- cord-328289-3h3kmjlz 63 2 Merad Merad NNP cord-328289-3h3kmjlz 63 3 and and CC cord-328289-3h3kmjlz 63 4 Martin Martin NNP cord-328289-3h3kmjlz 63 5 , , , cord-328289-3h3kmjlz 63 6 2020 2020 CD cord-328289-3h3kmjlz 63 7 ) ) -RRB- cord-328289-3h3kmjlz 63 8 . . . cord-328289-3h3kmjlz 64 1 SARS SARS NNP cord-328289-3h3kmjlz 64 2 - - HYPH cord-328289-3h3kmjlz 64 3 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 64 4 envelope envelope NN cord-328289-3h3kmjlz 65 1 NP NP NNP cord-328289-3h3kmjlz 65 2 protein protein NN cord-328289-3h3kmjlz 65 3 immunoreactivity immunoreactivity NN cord-328289-3h3kmjlz 65 4 was be VBD cord-328289-3h3kmjlz 65 5 observed observe VBN cord-328289-3h3kmjlz 65 6 in in IN cord-328289-3h3kmjlz 65 7 CD68 CD68 NNP cord-328289-3h3kmjlz 65 8 + + CC cord-328289-3h3kmjlz 65 9 cells cell NNS cord-328289-3h3kmjlz 65 10 in in IN cord-328289-3h3kmjlz 65 11 lymphoid lymphoid JJ cord-328289-3h3kmjlz 65 12 organs organ NNS cord-328289-3h3kmjlz 66 1 ( ( -LRB- cord-328289-3h3kmjlz 66 2 Chen Chen NNP cord-328289-3h3kmjlz 66 3 et et NNP cord-328289-3h3kmjlz 66 4 al al NNP cord-328289-3h3kmjlz 66 5 . . NNP cord-328289-3h3kmjlz 66 6 , , , cord-328289-3h3kmjlz 66 7 2020a 2020a CD cord-328289-3h3kmjlz 66 8 ) ) -RRB- cord-328289-3h3kmjlz 66 9 , , , cord-328289-3h3kmjlz 66 10 while while IN cord-328289-3h3kmjlz 66 11 single single JJ cord-328289-3h3kmjlz 66 12 - - HYPH cord-328289-3h3kmjlz 66 13 cell cell NN cord-328289-3h3kmjlz 66 14 RNA RNA NNP cord-328289-3h3kmjlz 66 15 seq seq NN cord-328289-3h3kmjlz 66 16 data datum NNS cord-328289-3h3kmjlz 66 17 showed show VBD cord-328289-3h3kmjlz 66 18 viral viral JJ cord-328289-3h3kmjlz 66 19 RNA RNA NNP cord-328289-3h3kmjlz 66 20 in in IN cord-328289-3h3kmjlz 66 21 macrophages macrophage NNS cord-328289-3h3kmjlz 66 22 in in IN cord-328289-3h3kmjlz 66 23 bronchoalveolar bronchoalveolar NNP cord-328289-3h3kmjlz 66 24 lavage lavage NN cord-328289-3h3kmjlz 66 25 of of IN cord-328289-3h3kmjlz 66 26 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 66 27 patients patient NNS cord-328289-3h3kmjlz 67 1 ( ( -LRB- cord-328289-3h3kmjlz 67 2 Bost Bost NNP cord-328289-3h3kmjlz 67 3 et et NNP cord-328289-3h3kmjlz 67 4 al al NNP cord-328289-3h3kmjlz 67 5 . . NNP cord-328289-3h3kmjlz 67 6 , , , cord-328289-3h3kmjlz 67 7 2020 2020 CD cord-328289-3h3kmjlz 67 8 ) ) -RRB- cord-328289-3h3kmjlz 67 9 . . . cord-328289-3h3kmjlz 68 1 But but CC cord-328289-3h3kmjlz 68 2 it -PRON- PRP cord-328289-3h3kmjlz 68 3 remains remain VBZ cord-328289-3h3kmjlz 68 4 unclear unclear JJ cord-328289-3h3kmjlz 68 5 if if IN cord-328289-3h3kmjlz 68 6 this this DT cord-328289-3h3kmjlz 68 7 is be VBZ cord-328289-3h3kmjlz 68 8 due due JJ cord-328289-3h3kmjlz 68 9 to to IN cord-328289-3h3kmjlz 68 10 actual actual JJ cord-328289-3h3kmjlz 68 11 virus virus NN cord-328289-3h3kmjlz 68 12 propagation propagation NN cord-328289-3h3kmjlz 68 13 in in IN cord-328289-3h3kmjlz 68 14 macrophages macrophage NNS cord-328289-3h3kmjlz 68 15 or or CC cord-328289-3h3kmjlz 68 16 to to TO cord-328289-3h3kmjlz 68 17 phagocytic phagocytic VB cord-328289-3h3kmjlz 68 18 uptake uptake NN cord-328289-3h3kmjlz 68 19 of of IN cord-328289-3h3kmjlz 68 20 virus virus NN cord-328289-3h3kmjlz 68 21 infected infect VBN cord-328289-3h3kmjlz 68 22 cells cell NNS cord-328289-3h3kmjlz 68 23 or or CC cord-328289-3h3kmjlz 68 24 extracellular extracellular JJ cord-328289-3h3kmjlz 68 25 virions virion NNS cord-328289-3h3kmjlz 68 26 ( ( -LRB- cord-328289-3h3kmjlz 68 27 Bost Bost NNP cord-328289-3h3kmjlz 68 28 et et NNP cord-328289-3h3kmjlz 68 29 al al NNP cord-328289-3h3kmjlz 68 30 . . NNP cord-328289-3h3kmjlz 68 31 , , , cord-328289-3h3kmjlz 68 32 2020 2020 CD cord-328289-3h3kmjlz 68 33 ; ; : cord-328289-3h3kmjlz 68 34 Merad Merad NNP cord-328289-3h3kmjlz 68 35 and and CC cord-328289-3h3kmjlz 68 36 Martin Martin NNP cord-328289-3h3kmjlz 68 37 , , , cord-328289-3h3kmjlz 68 38 2020 2020 CD cord-328289-3h3kmjlz 68 39 ) ) -RRB- cord-328289-3h3kmjlz 68 40 . . . cord-328289-3h3kmjlz 69 1 Furthermore furthermore RB cord-328289-3h3kmjlz 69 2 , , , cord-328289-3h3kmjlz 69 3 several several JJ cord-328289-3h3kmjlz 69 4 autopsy autopsy JJ cord-328289-3h3kmjlz 69 5 series series NN cord-328289-3h3kmjlz 69 6 have have VBP cord-328289-3h3kmjlz 69 7 revealed reveal VBN cord-328289-3h3kmjlz 69 8 a a DT cord-328289-3h3kmjlz 69 9 notable notable JJ cord-328289-3h3kmjlz 69 10 lack lack NN cord-328289-3h3kmjlz 69 11 of of IN cord-328289-3h3kmjlz 69 12 immune immune JJ cord-328289-3h3kmjlz 69 13 cell cell NN cord-328289-3h3kmjlz 69 14 infiltration infiltration NN cord-328289-3h3kmjlz 69 15 ( ( -LRB- cord-328289-3h3kmjlz 69 16 Kantonen Kantonen NNP cord-328289-3h3kmjlz 69 17 et et FW cord-328289-3h3kmjlz 69 18 al al NNP cord-328289-3h3kmjlz 69 19 . . NNP cord-328289-3h3kmjlz 69 20 , , , cord-328289-3h3kmjlz 69 21 2020 2020 CD cord-328289-3h3kmjlz 69 22 ; ; : cord-328289-3h3kmjlz 69 23 Reichard Reichard NNP cord-328289-3h3kmjlz 69 24 et et NNP cord-328289-3h3kmjlz 69 25 al al NNP cord-328289-3h3kmjlz 69 26 . . NNP cord-328289-3h3kmjlz 69 27 , , , cord-328289-3h3kmjlz 69 28 2020 2020 CD cord-328289-3h3kmjlz 69 29 ; ; . cord-328289-3h3kmjlz 70 1 Solomon Solomon NNP cord-328289-3h3kmjlz 70 2 et et NNP cord-328289-3h3kmjlz 70 3 al al NNP cord-328289-3h3kmjlz 70 4 . . NNP cord-328289-3h3kmjlz 70 5 , , , cord-328289-3h3kmjlz 70 6 2020 2020 CD cord-328289-3h3kmjlz 70 7 ) ) -RRB- cord-328289-3h3kmjlz 70 8 . . . cord-328289-3h3kmjlz 71 1 In in IN cord-328289-3h3kmjlz 71 2 summary summary NN cord-328289-3h3kmjlz 71 3 , , , cord-328289-3h3kmjlz 71 4 SARS SARS NNP cord-328289-3h3kmjlz 71 5 - - HYPH cord-328289-3h3kmjlz 71 6 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 71 7 can can MD cord-328289-3h3kmjlz 71 8 infect infect VB cord-328289-3h3kmjlz 71 9 neurons neuron NNS cord-328289-3h3kmjlz 71 10 in in IN cord-328289-3h3kmjlz 71 11 vitro vitro FW cord-328289-3h3kmjlz 71 12 and and CC cord-328289-3h3kmjlz 71 13 cause cause VB cord-328289-3h3kmjlz 71 14 neuronal neuronal JJ cord-328289-3h3kmjlz 71 15 death death NN cord-328289-3h3kmjlz 71 16 , , , cord-328289-3h3kmjlz 71 17 but but CC cord-328289-3h3kmjlz 71 18 data datum NNS cord-328289-3h3kmjlz 71 19 from from IN cord-328289-3h3kmjlz 71 20 CSF CSF NNP cord-328289-3h3kmjlz 71 21 and and CC cord-328289-3h3kmjlz 71 22 autopsy autopsy JJ cord-328289-3h3kmjlz 71 23 studies study NNS cord-328289-3h3kmjlz 71 24 do do VBP cord-328289-3h3kmjlz 71 25 not not RB cord-328289-3h3kmjlz 71 26 provide provide VB cord-328289-3h3kmjlz 71 27 consistent consistent JJ cord-328289-3h3kmjlz 71 28 evidence evidence NN cord-328289-3h3kmjlz 71 29 of of IN cord-328289-3h3kmjlz 71 30 direct direct JJ cord-328289-3h3kmjlz 71 31 CNS CNS NNP cord-328289-3h3kmjlz 71 32 invasion invasion NN cord-328289-3h3kmjlz 71 33 . . . cord-328289-3h3kmjlz 72 1 However however RB cord-328289-3h3kmjlz 72 2 , , , cord-328289-3h3kmjlz 72 3 effects effect NNS cord-328289-3h3kmjlz 72 4 on on IN cord-328289-3h3kmjlz 72 5 the the DT cord-328289-3h3kmjlz 72 6 median median JJ cord-328289-3h3kmjlz 72 7 eminence eminence NN cord-328289-3h3kmjlz 72 8 and and CC cord-328289-3h3kmjlz 72 9 other other JJ cord-328289-3h3kmjlz 72 10 circumventricular circumventricular JJ cord-328289-3h3kmjlz 72 11 organs organ NNS cord-328289-3h3kmjlz 72 12 , , , cord-328289-3h3kmjlz 72 13 can can MD cord-328289-3h3kmjlz 72 14 not not RB cord-328289-3h3kmjlz 72 15 be be VB cord-328289-3h3kmjlz 72 16 ruled rule VBN cord-328289-3h3kmjlz 72 17 out out RP cord-328289-3h3kmjlz 72 18 and and CC cord-328289-3h3kmjlz 72 19 may may MD cord-328289-3h3kmjlz 72 20 play play VB cord-328289-3h3kmjlz 72 21 a a DT cord-328289-3h3kmjlz 72 22 role role NN cord-328289-3h3kmjlz 72 23 in in IN cord-328289-3h3kmjlz 72 24 the the DT cord-328289-3h3kmjlz 72 25 systemic systemic JJ cord-328289-3h3kmjlz 72 26 manifestations manifestation NNS cord-328289-3h3kmjlz 72 27 of of IN cord-328289-3h3kmjlz 72 28 the the DT cord-328289-3h3kmjlz 72 29 disease disease NN cord-328289-3h3kmjlz 72 30 . . . cord-328289-3h3kmjlz 73 1 Lung lung NN cord-328289-3h3kmjlz 73 2 damage damage NN cord-328289-3h3kmjlz 73 3 and and CC cord-328289-3h3kmjlz 73 4 respiratory respiratory JJ cord-328289-3h3kmjlz 73 5 failure failure NN cord-328289-3h3kmjlz 73 6 : : : cord-328289-3h3kmjlz 73 7 The the DT cord-328289-3h3kmjlz 73 8 lung lung NN cord-328289-3h3kmjlz 73 9 is be VBZ cord-328289-3h3kmjlz 73 10 the the DT cord-328289-3h3kmjlz 73 11 organ organ NN cord-328289-3h3kmjlz 73 12 most most RBS cord-328289-3h3kmjlz 73 13 affected affect VBN cord-328289-3h3kmjlz 73 14 in in IN cord-328289-3h3kmjlz 73 15 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 73 16 , , , cord-328289-3h3kmjlz 73 17 with with IN cord-328289-3h3kmjlz 73 18 massive massive JJ cord-328289-3h3kmjlz 73 19 alveolar alveolar JJ cord-328289-3h3kmjlz 73 20 damage damage NN cord-328289-3h3kmjlz 73 21 , , , cord-328289-3h3kmjlz 73 22 edema edema NN cord-328289-3h3kmjlz 73 23 , , , cord-328289-3h3kmjlz 73 24 inflammatory inflammatory JJ cord-328289-3h3kmjlz 73 25 cell cell NN cord-328289-3h3kmjlz 73 26 infiltration infiltration NN cord-328289-3h3kmjlz 73 27 , , , cord-328289-3h3kmjlz 73 28 microvascular microvascular JJ cord-328289-3h3kmjlz 73 29 thrombosis thrombosis NN cord-328289-3h3kmjlz 73 30 , , , cord-328289-3h3kmjlz 73 31 microvascular microvascular JJ cord-328289-3h3kmjlz 73 32 damage damage NN cord-328289-3h3kmjlz 73 33 and and CC cord-328289-3h3kmjlz 73 34 hemorrhage hemorrhage NN cord-328289-3h3kmjlz 73 35 ( ( -LRB- cord-328289-3h3kmjlz 73 36 Carsana Carsana NNP cord-328289-3h3kmjlz 73 37 et et FW cord-328289-3h3kmjlz 73 38 al al NNP cord-328289-3h3kmjlz 73 39 . . NNP cord-328289-3h3kmjlz 73 40 , , , cord-328289-3h3kmjlz 73 41 2020 2020 CD cord-328289-3h3kmjlz 73 42 ) ) -RRB- cord-328289-3h3kmjlz 73 43 . . . cord-328289-3h3kmjlz 74 1 SARS SARS NNP cord-328289-3h3kmjlz 74 2 - - HYPH cord-328289-3h3kmjlz 74 3 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 74 4 has have VBZ cord-328289-3h3kmjlz 74 5 been be VBN cord-328289-3h3kmjlz 74 6 detected detect VBN cord-328289-3h3kmjlz 74 7 mainly mainly RB cord-328289-3h3kmjlz 74 8 in in IN cord-328289-3h3kmjlz 74 9 pneumocytes pneumocyte NNS cord-328289-3h3kmjlz 74 10 and and CC cord-328289-3h3kmjlz 74 11 epithelial epithelial JJ cord-328289-3h3kmjlz 74 12 progenitors progenitor NNS cord-328289-3h3kmjlz 74 13 ( ( -LRB- cord-328289-3h3kmjlz 74 14 Bost Bost NNP cord-328289-3h3kmjlz 74 15 et et NNP cord-328289-3h3kmjlz 74 16 al al NNP cord-328289-3h3kmjlz 74 17 . . . cord-328289-3h3kmjlz 75 1 , , , cord-328289-3h3kmjlz 75 2 2020 2020 CD cord-328289-3h3kmjlz 75 3 ; ; : cord-328289-3h3kmjlz 75 4 Carsana Carsana NNP cord-328289-3h3kmjlz 75 5 et et FW cord-328289-3h3kmjlz 75 6 al al NNP cord-328289-3h3kmjlz 75 7 . . NNP cord-328289-3h3kmjlz 75 8 , , , cord-328289-3h3kmjlz 75 9 2020 2020 CD cord-328289-3h3kmjlz 75 10 ) ) -RRB- cord-328289-3h3kmjlz 75 11 . . . cord-328289-3h3kmjlz 76 1 The the DT cord-328289-3h3kmjlz 76 2 respiratory respiratory JJ cord-328289-3h3kmjlz 76 3 failure failure NN cord-328289-3h3kmjlz 76 4 resulting result VBG cord-328289-3h3kmjlz 76 5 from from IN cord-328289-3h3kmjlz 76 6 lung lung NN cord-328289-3h3kmjlz 76 7 damage damage NN cord-328289-3h3kmjlz 76 8 leads lead VBZ cord-328289-3h3kmjlz 76 9 to to IN cord-328289-3h3kmjlz 76 10 severe severe JJ cord-328289-3h3kmjlz 76 11 hypoxia hypoxia NN cord-328289-3h3kmjlz 76 12 ( ( -LRB- cord-328289-3h3kmjlz 76 13 adult adult NN cord-328289-3h3kmjlz 76 14 respiratory respiratory JJ cord-328289-3h3kmjlz 76 15 distress distress NN cord-328289-3h3kmjlz 76 16 syndrome syndrome NN cord-328289-3h3kmjlz 76 17 , , , cord-328289-3h3kmjlz 76 18 ARDS ARDS NNP cord-328289-3h3kmjlz 76 19 ) ) -RRB- cord-328289-3h3kmjlz 76 20 , , , cord-328289-3h3kmjlz 76 21 requiring require VBG cord-328289-3h3kmjlz 76 22 assisted assist VBN cord-328289-3h3kmjlz 76 23 ventilation ventilation NN cord-328289-3h3kmjlz 77 1 ( ( -LRB- cord-328289-3h3kmjlz 77 2 Grasselli Grasselli NNP cord-328289-3h3kmjlz 77 3 et et NNP cord-328289-3h3kmjlz 77 4 al al NNP cord-328289-3h3kmjlz 77 5 . . NNP cord-328289-3h3kmjlz 77 6 , , , cord-328289-3h3kmjlz 77 7 2020 2020 CD cord-328289-3h3kmjlz 77 8 ) ) -RRB- cord-328289-3h3kmjlz 77 9 . . . cord-328289-3h3kmjlz 78 1 Consistent consistent JJ cord-328289-3h3kmjlz 78 2 with with IN cord-328289-3h3kmjlz 78 3 hypoxic hypoxic JJ cord-328289-3h3kmjlz 78 4 brain brain NN cord-328289-3h3kmjlz 78 5 injury injury NN cord-328289-3h3kmjlz 78 6 , , , cord-328289-3h3kmjlz 78 7 autopsy autopsy JJ cord-328289-3h3kmjlz 78 8 studies study NNS cord-328289-3h3kmjlz 78 9 in in IN cord-328289-3h3kmjlz 78 10 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 78 11 have have VBP cord-328289-3h3kmjlz 78 12 shown show VBN cord-328289-3h3kmjlz 78 13 neuronal neuronal JJ cord-328289-3h3kmjlz 78 14 damage damage NN cord-328289-3h3kmjlz 78 15 in in IN cord-328289-3h3kmjlz 78 16 brain brain NN cord-328289-3h3kmjlz 78 17 regions region NNS cord-328289-3h3kmjlz 78 18 most most RBS cord-328289-3h3kmjlz 78 19 vulnerable vulnerable JJ cord-328289-3h3kmjlz 78 20 to to IN cord-328289-3h3kmjlz 78 21 hypoxia hypoxia NN cord-328289-3h3kmjlz 78 22 , , , cord-328289-3h3kmjlz 78 23 including include VBG cord-328289-3h3kmjlz 78 24 neocortex neocortex NN cord-328289-3h3kmjlz 78 25 , , , cord-328289-3h3kmjlz 78 26 hippocampus hippocampus NN cord-328289-3h3kmjlz 78 27 and and CC cord-328289-3h3kmjlz 78 28 cerebellum cerebellum NN cord-328289-3h3kmjlz 78 29 ( ( -LRB- cord-328289-3h3kmjlz 78 30 Kantonen Kantonen NNP cord-328289-3h3kmjlz 78 31 et et NNP cord-328289-3h3kmjlz 78 32 al al NNP cord-328289-3h3kmjlz 78 33 . . NNP cord-328289-3h3kmjlz 78 34 , , , cord-328289-3h3kmjlz 78 35 2020 2020 CD cord-328289-3h3kmjlz 78 36 ; ; . cord-328289-3h3kmjlz 79 1 Reichard Reichard NNP cord-328289-3h3kmjlz 79 2 et et NNP cord-328289-3h3kmjlz 79 3 al al NNP cord-328289-3h3kmjlz 79 4 . . NNP cord-328289-3h3kmjlz 79 5 , , , cord-328289-3h3kmjlz 79 6 2020 2020 CD cord-328289-3h3kmjlz 80 1 ; ; : cord-328289-3h3kmjlz 80 2 Solomon Solomon NNP cord-328289-3h3kmjlz 80 3 et et NNP cord-328289-3h3kmjlz 80 4 al al NNP cord-328289-3h3kmjlz 80 5 . . NNP cord-328289-3h3kmjlz 80 6 , , , cord-328289-3h3kmjlz 80 7 2020 2020 CD cord-328289-3h3kmjlz 80 8 ) ) -RRB- cord-328289-3h3kmjlz 80 9 . . . cord-328289-3h3kmjlz 81 1 A a DT cord-328289-3h3kmjlz 81 2 key key JJ cord-328289-3h3kmjlz 81 3 feature feature NN cord-328289-3h3kmjlz 81 4 of of IN cord-328289-3h3kmjlz 81 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 81 6 is be VBZ cord-328289-3h3kmjlz 81 7 a a DT cord-328289-3h3kmjlz 81 8 maladaptive maladaptive JJ cord-328289-3h3kmjlz 81 9 immune immune JJ cord-328289-3h3kmjlz 81 10 response response NN cord-328289-3h3kmjlz 81 11 characterized characterize VBN cord-328289-3h3kmjlz 81 12 by by IN cord-328289-3h3kmjlz 81 13 hyperactivity hyperactivity NN cord-328289-3h3kmjlz 81 14 of of IN cord-328289-3h3kmjlz 81 15 innate innate JJ cord-328289-3h3kmjlz 81 16 immunity immunity NN cord-328289-3h3kmjlz 81 17 followed follow VBN cord-328289-3h3kmjlz 81 18 by by IN cord-328289-3h3kmjlz 81 19 immunosuppression immunosuppression NN cord-328289-3h3kmjlz 82 1 ( ( -LRB- cord-328289-3h3kmjlz 82 2 Diao Diao NNP cord-328289-3h3kmjlz 82 3 et et FW cord-328289-3h3kmjlz 82 4 al al NNP cord-328289-3h3kmjlz 82 5 . . . cord-328289-3h3kmjlz 83 1 , , , cord-328289-3h3kmjlz 83 2 2020 2020 CD cord-328289-3h3kmjlz 83 3 ; ; : cord-328289-3h3kmjlz 83 4 Qin Qin NNP cord-328289-3h3kmjlz 83 5 et et FW cord-328289-3h3kmjlz 83 6 al al NNP cord-328289-3h3kmjlz 83 7 . . NNP cord-328289-3h3kmjlz 83 8 , , , cord-328289-3h3kmjlz 83 9 2020 2020 CD cord-328289-3h3kmjlz 83 10 ; ; : cord-328289-3h3kmjlz 83 11 Vabret Vabret NNP cord-328289-3h3kmjlz 83 12 et et NNP cord-328289-3h3kmjlz 83 13 al al NNP cord-328289-3h3kmjlz 84 1 . . . cord-328289-3h3kmjlz 85 1 , , , cord-328289-3h3kmjlz 85 2 2020 2020 CD cord-328289-3h3kmjlz 85 3 ; ; : cord-328289-3h3kmjlz 85 4 Zhou Zhou NNP cord-328289-3h3kmjlz 85 5 et et NNP cord-328289-3h3kmjlz 85 6 al al NNP cord-328289-3h3kmjlz 85 7 . . NNP cord-328289-3h3kmjlz 85 8 , , , cord-328289-3h3kmjlz 85 9 2020 2020 CD cord-328289-3h3kmjlz 85 10 ) ) -RRB- cord-328289-3h3kmjlz 85 11 . . . cord-328289-3h3kmjlz 86 1 Improvement improvement NN cord-328289-3h3kmjlz 86 2 of of IN cord-328289-3h3kmjlz 86 3 T t NN cord-328289-3h3kmjlz 86 4 - - HYPH cord-328289-3h3kmjlz 86 5 cell cell NN cord-328289-3h3kmjlz 86 6 function function NN cord-328289-3h3kmjlz 86 7 coincides coincide VBZ cord-328289-3h3kmjlz 86 8 with with IN cord-328289-3h3kmjlz 86 9 remission remission NN cord-328289-3h3kmjlz 86 10 of of IN cord-328289-3h3kmjlz 86 11 symptoms symptom NNS cord-328289-3h3kmjlz 86 12 and and CC cord-328289-3h3kmjlz 86 13 declining decline VBG cord-328289-3h3kmjlz 86 14 viral viral JJ cord-328289-3h3kmjlz 86 15 loads load NNS cord-328289-3h3kmjlz 86 16 ( ( -LRB- cord-328289-3h3kmjlz 86 17 Thevarajan Thevarajan NNP cord-328289-3h3kmjlz 86 18 et et FW cord-328289-3h3kmjlz 86 19 al al NNP cord-328289-3h3kmjlz 86 20 . . NNP cord-328289-3h3kmjlz 86 21 , , , cord-328289-3h3kmjlz 86 22 2020 2020 CD cord-328289-3h3kmjlz 86 23 ) ) -RRB- cord-328289-3h3kmjlz 86 24 , , , cord-328289-3h3kmjlz 86 25 attesting attest VBG cord-328289-3h3kmjlz 86 26 to to IN cord-328289-3h3kmjlz 86 27 the the DT cord-328289-3h3kmjlz 86 28 link link NN cord-328289-3h3kmjlz 86 29 between between IN cord-328289-3h3kmjlz 86 30 immuno immuno JJ cord-328289-3h3kmjlz 86 31 - - JJ cord-328289-3h3kmjlz 86 32 suppression suppression NN cord-328289-3h3kmjlz 86 33 and and CC cord-328289-3h3kmjlz 86 34 disease disease NN cord-328289-3h3kmjlz 86 35 severity severity NN cord-328289-3h3kmjlz 86 36 . . . cord-328289-3h3kmjlz 87 1 In in IN cord-328289-3h3kmjlz 87 2 patients patient NNS cord-328289-3h3kmjlz 87 3 with with IN cord-328289-3h3kmjlz 87 4 severe severe JJ cord-328289-3h3kmjlz 87 5 disease disease NN cord-328289-3h3kmjlz 87 6 , , , cord-328289-3h3kmjlz 87 7 the the DT cord-328289-3h3kmjlz 87 8 cytokine cytokine NN cord-328289-3h3kmjlz 87 9 release release NN cord-328289-3h3kmjlz 87 10 syndrome syndrome NN cord-328289-3h3kmjlz 87 11 can can MD cord-328289-3h3kmjlz 87 12 develop develop VB cord-328289-3h3kmjlz 87 13 ( ( -LRB- cord-328289-3h3kmjlz 87 14 Qin Qin NNP cord-328289-3h3kmjlz 87 15 et et FW cord-328289-3h3kmjlz 87 16 al al NNP cord-328289-3h3kmjlz 87 17 . . NNP cord-328289-3h3kmjlz 87 18 , , , cord-328289-3h3kmjlz 87 19 2020 2020 CD cord-328289-3h3kmjlz 87 20 ; ; : cord-328289-3h3kmjlz 87 21 Xu Xu NNP cord-328289-3h3kmjlz 87 22 et et NNP cord-328289-3h3kmjlz 87 23 al al NNP cord-328289-3h3kmjlz 87 24 . . NNP cord-328289-3h3kmjlz 87 25 , , , cord-328289-3h3kmjlz 87 26 2020 2020 CD cord-328289-3h3kmjlz 87 27 ) ) -RRB- cord-328289-3h3kmjlz 87 28 . . . cord-328289-3h3kmjlz 88 1 Most Most JJS cord-328289-3h3kmjlz 88 2 COVID-19 covid-19 CD cord-328289-3h3kmjlz 88 3 patients patient NNS cord-328289-3h3kmjlz 88 4 exhibit exhibit VBP cord-328289-3h3kmjlz 88 5 increased increase VBN cord-328289-3h3kmjlz 88 6 circulating circulate VBG cord-328289-3h3kmjlz 88 7 levels level NNS cord-328289-3h3kmjlz 88 8 of of IN cord-328289-3h3kmjlz 88 9 IL-6 IL-6 NNP cord-328289-3h3kmjlz 88 10 IL-1β IL-1β NNP cord-328289-3h3kmjlz 88 11 , , , cord-328289-3h3kmjlz 88 12 and and CC cord-328289-3h3kmjlz 88 13 TNF TNF NNP cord-328289-3h3kmjlz 88 14 , , , cord-328289-3h3kmjlz 88 15 as as RB cord-328289-3h3kmjlz 88 16 well well RB cord-328289-3h3kmjlz 88 17 as as IN cord-328289-3h3kmjlz 88 18 IL-2 IL-2 NNP cord-328289-3h3kmjlz 88 19 , , , cord-328289-3h3kmjlz 88 20 IL-8 IL-8 NNP cord-328289-3h3kmjlz 88 21 , , , cord-328289-3h3kmjlz 88 22 IL-17 IL-17 NNP cord-328289-3h3kmjlz 88 23 , , , cord-328289-3h3kmjlz 88 24 G G NNP cord-328289-3h3kmjlz 88 25 - - HYPH cord-328289-3h3kmjlz 88 26 CSF CSF NNP cord-328289-3h3kmjlz 88 27 , , , cord-328289-3h3kmjlz 88 28 GM GM NNP cord-328289-3h3kmjlz 88 29 - - HYPH cord-328289-3h3kmjlz 88 30 CSF CSF NNP cord-328289-3h3kmjlz 88 31 , , , cord-328289-3h3kmjlz 88 32 IP10 IP10 NNP cord-328289-3h3kmjlz 88 33 , , , cord-328289-3h3kmjlz 88 34 MCP1 MCP1 NNP cord-328289-3h3kmjlz 88 35 , , , cord-328289-3h3kmjlz 88 36 and and CC cord-328289-3h3kmjlz 88 37 MIP1α2 MIP1α2 NNP cord-328289-3h3kmjlz 88 38 , , , cord-328289-3h3kmjlz 88 39 and and CC cord-328289-3h3kmjlz 88 40 serum serum NN cord-328289-3h3kmjlz 88 41 levels level NNS cord-328289-3h3kmjlz 88 42 of of IN cord-328289-3h3kmjlz 88 43 IL-6 IL-6 NNP cord-328289-3h3kmjlz 88 44 and and CC cord-328289-3h3kmjlz 88 45 TNF TNF NNP cord-328289-3h3kmjlz 89 1 reflect reflect VB cord-328289-3h3kmjlz 89 2 disease disease NN cord-328289-3h3kmjlz 89 3 severity severity NN cord-328289-3h3kmjlz 89 4 ( ( -LRB- cord-328289-3h3kmjlz 89 5 Diao Diao NNP cord-328289-3h3kmjlz 89 6 et et FW cord-328289-3h3kmjlz 89 7 al al NNP cord-328289-3h3kmjlz 89 8 . . NNP cord-328289-3h3kmjlz 89 9 , , , cord-328289-3h3kmjlz 89 10 2020 2020 CD cord-328289-3h3kmjlz 89 11 ) ) -RRB- cord-328289-3h3kmjlz 89 12 . . . cord-328289-3h3kmjlz 90 1 Even even RB cord-328289-3h3kmjlz 90 2 in in IN cord-328289-3h3kmjlz 90 3 the the DT cord-328289-3h3kmjlz 90 4 absence absence NN cord-328289-3h3kmjlz 90 5 of of IN cord-328289-3h3kmjlz 90 6 SARS SARS NNP cord-328289-3h3kmjlz 90 7 - - HYPH cord-328289-3h3kmjlz 90 8 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 90 9 brain brain NN cord-328289-3h3kmjlz 90 10 invasion invasion NN cord-328289-3h3kmjlz 90 11 , , , cord-328289-3h3kmjlz 90 12 viral viral JJ cord-328289-3h3kmjlz 90 13 proteins protein NNS cord-328289-3h3kmjlz 90 14 shed shed VBN cord-328289-3h3kmjlz 90 15 in in IN cord-328289-3h3kmjlz 90 16 the the DT cord-328289-3h3kmjlz 90 17 circulation circulation NN cord-328289-3h3kmjlz 90 18 and and CC cord-328289-3h3kmjlz 90 19 molecular molecular JJ cord-328289-3h3kmjlz 90 20 complexes complex NNS cord-328289-3h3kmjlz 90 21 from from IN cord-328289-3h3kmjlz 90 22 damaged damaged JJ cord-328289-3h3kmjlz 90 23 cells cell NNS cord-328289-3h3kmjlz 90 24 , , , cord-328289-3h3kmjlz 90 25 such such JJ cord-328289-3h3kmjlz 90 26 as as IN cord-328289-3h3kmjlz 90 27 the the DT cord-328289-3h3kmjlz 90 28 nuclear nuclear JJ cord-328289-3h3kmjlz 90 29 protein protein NN cord-328289-3h3kmjlz 90 30 high high JJ cord-328289-3h3kmjlz 90 31 mobility mobility NN cord-328289-3h3kmjlz 90 32 group group NN cord-328289-3h3kmjlz 90 33 box box NN cord-328289-3h3kmjlz 90 34 1 1 CD cord-328289-3h3kmjlz 90 35 ( ( -LRB- cord-328289-3h3kmjlz 90 36 HMGB1 HMGB1 NNP cord-328289-3h3kmjlz 90 37 ) ) -RRB- cord-328289-3h3kmjlz 91 1 ( ( -LRB- cord-328289-3h3kmjlz 91 2 Chen Chen NNP cord-328289-3h3kmjlz 91 3 et et NNP cord-328289-3h3kmjlz 91 4 al al NNP cord-328289-3h3kmjlz 91 5 . . NNP cord-328289-3h3kmjlz 91 6 , , , cord-328289-3h3kmjlz 91 7 2020b 2020b CD cord-328289-3h3kmjlz 91 8 ) ) -RRB- cord-328289-3h3kmjlz 91 9 , , , cord-328289-3h3kmjlz 91 10 could could MD cord-328289-3h3kmjlz 91 11 enter enter VB cord-328289-3h3kmjlz 91 12 the the DT cord-328289-3h3kmjlz 91 13 brain brain NN cord-328289-3h3kmjlz 91 14 through through IN cord-328289-3h3kmjlz 91 15 a a DT cord-328289-3h3kmjlz 91 16 compromised compromised JJ cord-328289-3h3kmjlz 91 17 BBB bbb NN cord-328289-3h3kmjlz 91 18 ( ( -LRB- cord-328289-3h3kmjlz 91 19 Figure figure NN cord-328289-3h3kmjlz 91 20 2 2 CD cord-328289-3h3kmjlz 91 21 ) ) -RRB- cord-328289-3h3kmjlz 91 22 . . . cord-328289-3h3kmjlz 92 1 After after IN cord-328289-3h3kmjlz 92 2 brain brain NN cord-328289-3h3kmjlz 92 3 entry entry NN cord-328289-3h3kmjlz 92 4 , , , cord-328289-3h3kmjlz 92 5 these these DT cord-328289-3h3kmjlz 92 6 molecules molecule NNS cord-328289-3h3kmjlz 92 7 could could MD cord-328289-3h3kmjlz 92 8 act act VB cord-328289-3h3kmjlz 92 9 as as IN cord-328289-3h3kmjlz 92 10 pathogen pathogen NN cord-328289-3h3kmjlz 92 11 associated associate VBD cord-328289-3h3kmjlz 92 12 molecular molecular JJ cord-328289-3h3kmjlz 92 13 patterns pattern NNS cord-328289-3h3kmjlz 92 14 ( ( -LRB- cord-328289-3h3kmjlz 92 15 PAMPs PAMPs NNP cord-328289-3h3kmjlz 92 16 ) ) -RRB- cord-328289-3h3kmjlz 92 17 and and CC cord-328289-3h3kmjlz 92 18 damageassociated damageassociate VBN cord-328289-3h3kmjlz 92 19 molecular molecular JJ cord-328289-3h3kmjlz 92 20 patters patter NNS cord-328289-3h3kmjlz 92 21 ( ( -LRB- cord-328289-3h3kmjlz 92 22 DAMPs damp NNS cord-328289-3h3kmjlz 92 23 ) ) -RRB- cord-328289-3h3kmjlz 92 24 , , , cord-328289-3h3kmjlz 92 25 and and CC cord-328289-3h3kmjlz 92 26 induce induce VB cord-328289-3h3kmjlz 92 27 an an DT cord-328289-3h3kmjlz 92 28 innate innate JJ cord-328289-3h3kmjlz 92 29 immune immune JJ cord-328289-3h3kmjlz 92 30 response response NN cord-328289-3h3kmjlz 92 31 in in IN cord-328289-3h3kmjlz 92 32 pericytes pericyte NNS cord-328289-3h3kmjlz 92 33 , , , cord-328289-3h3kmjlz 92 34 brain brain NN cord-328289-3h3kmjlz 92 35 - - HYPH cord-328289-3h3kmjlz 92 36 resident resident NN cord-328289-3h3kmjlz 92 37 macrophages macrophage NNS cord-328289-3h3kmjlz 92 38 and and CC cord-328289-3h3kmjlz 92 39 microglia microglia NNS cord-328289-3h3kmjlz 92 40 , , , cord-328289-3h3kmjlz 92 41 which which WDT cord-328289-3h3kmjlz 92 42 express express VBP cord-328289-3h3kmjlz 92 43 toll toll NN cord-328289-3h3kmjlz 92 44 - - HYPH cord-328289-3h3kmjlz 92 45 like like JJ cord-328289-3h3kmjlz 92 46 receptors receptor NNS cord-328289-3h3kmjlz 92 47 ( ( -LRB- cord-328289-3h3kmjlz 92 48 TLR TLR NNP cord-328289-3h3kmjlz 92 49 ) ) -RRB- cord-328289-3h3kmjlz 92 50 ( ( -LRB- cord-328289-3h3kmjlz 92 51 Figure figure NN cord-328289-3h3kmjlz 92 52 2 2 CD cord-328289-3h3kmjlz 92 53 ) ) -RRB- cord-328289-3h3kmjlz 92 54 . . . cord-328289-3h3kmjlz 93 1 TLR2 TLR2 NNP cord-328289-3h3kmjlz 93 2 mediates mediate VBZ cord-328289-3h3kmjlz 93 3 the the DT cord-328289-3h3kmjlz 93 4 pro pro JJ cord-328289-3h3kmjlz 93 5 - - JJ cord-328289-3h3kmjlz 93 6 inflammatory inflammatory JJ cord-328289-3h3kmjlz 93 7 effects effect NNS cord-328289-3h3kmjlz 93 8 of of IN cord-328289-3h3kmjlz 93 9 SARS SARS NNP cord-328289-3h3kmjlz 93 10 - - HYPH cord-328289-3h3kmjlz 93 11 CoV CoV NNP cord-328289-3h3kmjlz 93 12 spike spike NN cord-328289-3h3kmjlz 93 13 protein protein NN cord-328289-3h3kmjlz 93 14 on on IN cord-328289-3h3kmjlz 93 15 human human JJ cord-328289-3h3kmjlz 93 16 macrophages macrophage NNS cord-328289-3h3kmjlz 93 17 through through IN cord-328289-3h3kmjlz 93 18 NF nf NN cord-328289-3h3kmjlz 93 19 - - HYPH cord-328289-3h3kmjlz 93 20 κB κB NNP cord-328289-3h3kmjlz 94 1 ( ( -LRB- cord-328289-3h3kmjlz 94 2 Dosch Dosch NNP cord-328289-3h3kmjlz 94 3 et et NNP cord-328289-3h3kmjlz 94 4 al al NNP cord-328289-3h3kmjlz 94 5 . . NNP cord-328289-3h3kmjlz 94 6 , , , cord-328289-3h3kmjlz 94 7 2009 2009 CD cord-328289-3h3kmjlz 94 8 ) ) -RRB- cord-328289-3h3kmjlz 94 9 . . . cord-328289-3h3kmjlz 95 1 Such such JJ cord-328289-3h3kmjlz 95 2 innate innate JJ cord-328289-3h3kmjlz 95 3 immune immune JJ cord-328289-3h3kmjlz 95 4 response response NN cord-328289-3h3kmjlz 95 5 increases increase VBZ cord-328289-3h3kmjlz 95 6 cytokine cytokine NN cord-328289-3h3kmjlz 95 7 production production NN cord-328289-3h3kmjlz 95 8 and and CC cord-328289-3h3kmjlz 95 9 impair impair VB cord-328289-3h3kmjlz 95 10 brain brain NN cord-328289-3h3kmjlz 95 11 function function NN cord-328289-3h3kmjlz 95 12 ( ( -LRB- cord-328289-3h3kmjlz 95 13 Dantzer Dantzer NNP cord-328289-3h3kmjlz 95 14 , , , cord-328289-3h3kmjlz 95 15 2018 2018 CD cord-328289-3h3kmjlz 95 16 ) ) -RRB- cord-328289-3h3kmjlz 95 17 . . . cord-328289-3h3kmjlz 96 1 In in IN cord-328289-3h3kmjlz 96 2 mice mouse NNS cord-328289-3h3kmjlz 96 3 , , , cord-328289-3h3kmjlz 96 4 viral viral JJ cord-328289-3h3kmjlz 96 5 infections infection NNS cord-328289-3h3kmjlz 96 6 increase increase VBP cord-328289-3h3kmjlz 96 7 circulating circulate VBG cord-328289-3h3kmjlz 96 8 levels level NNS cord-328289-3h3kmjlz 96 9 of of IN cord-328289-3h3kmjlz 96 10 IFNα IFNα NNP cord-328289-3h3kmjlz 96 11 / / SYM cord-328289-3h3kmjlz 96 12 β β NNP cord-328289-3h3kmjlz 96 13 leading lead VBG cord-328289-3h3kmjlz 96 14 to to TO cord-328289-3h3kmjlz 96 15 activation activation NN cord-328289-3h3kmjlz 96 16 IFNR1 ifnr1 NN cord-328289-3h3kmjlz 96 17 on on IN cord-328289-3h3kmjlz 96 18 cerebral cerebral JJ cord-328289-3h3kmjlz 96 19 endothelial endothelial JJ cord-328289-3h3kmjlz 96 20 cells cell NNS cord-328289-3h3kmjlz 96 21 and and CC cord-328289-3h3kmjlz 96 22 CXCL10-CXCR3-mediated cxcl10-cxcr3-mediated JJ cord-328289-3h3kmjlz 96 23 cognitive cognitive JJ cord-328289-3h3kmjlz 96 24 impairment impairment NN cord-328289-3h3kmjlz 96 25 ( ( -LRB- cord-328289-3h3kmjlz 96 26 cytokine cytokine NN cord-328289-3h3kmjlz 96 27 sickness sickness NN cord-328289-3h3kmjlz 96 28 behavior behavior NN cord-328289-3h3kmjlz 96 29 ) ) -RRB- cord-328289-3h3kmjlz 97 1 ( ( -LRB- cord-328289-3h3kmjlz 97 2 Dantzer Dantzer NNP cord-328289-3h3kmjlz 97 3 , , , cord-328289-3h3kmjlz 97 4 2018 2018 CD cord-328289-3h3kmjlz 97 5 ) ) -RRB- cord-328289-3h3kmjlz 97 6 . . . cord-328289-3h3kmjlz 98 1 An an DT cord-328289-3h3kmjlz 98 2 IFN IFN NNP cord-328289-3h3kmjlz 98 3 type type NN cord-328289-3h3kmjlz 98 4 I -PRON- PRP cord-328289-3h3kmjlz 98 5 response response NN cord-328289-3h3kmjlz 98 6 does do VBZ cord-328289-3h3kmjlz 98 7 occur occur VB cord-328289-3h3kmjlz 98 8 in in IN cord-328289-3h3kmjlz 98 9 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 98 10 and and CC cord-328289-3h3kmjlz 98 11 is be VBZ cord-328289-3h3kmjlz 98 12 thought think VBN cord-328289-3h3kmjlz 98 13 to to TO cord-328289-3h3kmjlz 98 14 be be VB cord-328289-3h3kmjlz 98 15 protective protective JJ cord-328289-3h3kmjlz 99 1 ( ( -LRB- cord-328289-3h3kmjlz 99 2 Merad Merad NNP cord-328289-3h3kmjlz 99 3 and and CC cord-328289-3h3kmjlz 99 4 Martin Martin NNP cord-328289-3h3kmjlz 99 5 , , , cord-328289-3h3kmjlz 99 6 2020 2020 CD cord-328289-3h3kmjlz 99 7 ) ) -RRB- cord-328289-3h3kmjlz 99 8 , , , cord-328289-3h3kmjlz 99 9 but but CC cord-328289-3h3kmjlz 99 10 could could MD cord-328289-3h3kmjlz 99 11 contribute contribute VB cord-328289-3h3kmjlz 99 12 to to IN cord-328289-3h3kmjlz 99 13 the the DT cord-328289-3h3kmjlz 99 14 alterations alteration NNS cord-328289-3h3kmjlz 99 15 in in IN cord-328289-3h3kmjlz 99 16 consciousness consciousness NN cord-328289-3h3kmjlz 100 1 ( ( -LRB- cord-328289-3h3kmjlz 100 2 see see VB cord-328289-3h3kmjlz 100 3 Neurological Neurological NNP cord-328289-3h3kmjlz 100 4 Manifestation Manifestation NNP cord-328289-3h3kmjlz 100 5 of of IN cord-328289-3h3kmjlz 100 6 The the DT cord-328289-3h3kmjlz 100 7 hypothalamus hypothalamus NN cord-328289-3h3kmjlz 100 8 : : : cord-328289-3h3kmjlz 101 1 target target NN cord-328289-3h3kmjlz 101 2 and and CC cord-328289-3h3kmjlz 101 3 culprit culprit NN cord-328289-3h3kmjlz 101 4 of of IN cord-328289-3h3kmjlz 101 5 immune immune JJ cord-328289-3h3kmjlz 101 6 dysregulation dysregulation NN cord-328289-3h3kmjlz 101 7 : : : cord-328289-3h3kmjlz 101 8 The the DT cord-328289-3h3kmjlz 101 9 brain brain NN cord-328289-3h3kmjlz 101 10 , , , cord-328289-3h3kmjlz 101 11 the the DT cord-328289-3h3kmjlz 101 12 hypothalamus hypothalamus NN cord-328289-3h3kmjlz 101 13 in in IN cord-328289-3h3kmjlz 101 14 particular particular JJ cord-328289-3h3kmjlz 101 15 , , , cord-328289-3h3kmjlz 101 16 could could MD cord-328289-3h3kmjlz 101 17 also also RB cord-328289-3h3kmjlz 101 18 contribute contribute VB cord-328289-3h3kmjlz 101 19 to to IN cord-328289-3h3kmjlz 101 20 the the DT cord-328289-3h3kmjlz 101 21 immune immune JJ cord-328289-3h3kmjlz 101 22 dysregulation dysregulation NN cord-328289-3h3kmjlz 101 23 ( ( -LRB- cord-328289-3h3kmjlz 101 24 Figure figure NN cord-328289-3h3kmjlz 101 25 3 3 CD cord-328289-3h3kmjlz 101 26 ) ) -RRB- cord-328289-3h3kmjlz 101 27 . . . cord-328289-3h3kmjlz 102 1 Several several JJ cord-328289-3h3kmjlz 102 2 cytokines cytokine NNS cord-328289-3h3kmjlz 102 3 upregulated upregulate VBN cord-328289-3h3kmjlz 102 4 in in IN cord-328289-3h3kmjlz 102 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 102 6 ( ( -LRB- cord-328289-3h3kmjlz 102 7 IL-6 IL-6 NNP cord-328289-3h3kmjlz 102 8 , , , cord-328289-3h3kmjlz 102 9 IL-1β IL-1β NNP cord-328289-3h3kmjlz 102 10 , , , cord-328289-3h3kmjlz 102 11 TNF TNF NNP cord-328289-3h3kmjlz 102 12 ) ) -RRB- cord-328289-3h3kmjlz 102 13 are be VBP cord-328289-3h3kmjlz 102 14 powerful powerful JJ cord-328289-3h3kmjlz 102 15 activators activator NNS cord-328289-3h3kmjlz 102 16 of of IN cord-328289-3h3kmjlz 102 17 the the DT cord-328289-3h3kmjlz 102 18 hypothalamic hypothalamic JJ cord-328289-3h3kmjlz 102 19 - - HYPH cord-328289-3h3kmjlz 102 20 pituitary pituitary NN cord-328289-3h3kmjlz 102 21 - - HYPH cord-328289-3h3kmjlz 102 22 adrenocortical adrenocortical NN cord-328289-3h3kmjlz 102 23 ( ( -LRB- cord-328289-3h3kmjlz 102 24 HPA HPA NNP cord-328289-3h3kmjlz 102 25 ) ) -RRB- cord-328289-3h3kmjlz 102 26 axis axis NN cord-328289-3h3kmjlz 102 27 ( ( -LRB- cord-328289-3h3kmjlz 102 28 Dantzer Dantzer NNP cord-328289-3h3kmjlz 102 29 , , , cord-328289-3h3kmjlz 102 30 2018 2018 CD cord-328289-3h3kmjlz 102 31 ) ) -RRB- cord-328289-3h3kmjlz 102 32 . . . cord-328289-3h3kmjlz 103 1 The the DT cord-328289-3h3kmjlz 103 2 HPA HPA NNP cord-328289-3h3kmjlz 103 3 axis axis NN cord-328289-3h3kmjlz 103 4 is be VBZ cord-328289-3h3kmjlz 103 5 central central JJ cord-328289-3h3kmjlz 103 6 to to IN cord-328289-3h3kmjlz 103 7 the the DT cord-328289-3h3kmjlz 103 8 regulation regulation NN cord-328289-3h3kmjlz 103 9 of of IN cord-328289-3h3kmjlz 103 10 systemic systemic JJ cord-328289-3h3kmjlz 103 11 immune immune JJ cord-328289-3h3kmjlz 103 12 activity activity NN cord-328289-3h3kmjlz 103 13 and and CC cord-328289-3h3kmjlz 103 14 is be VBZ cord-328289-3h3kmjlz 103 15 activated activate VBN cord-328289-3h3kmjlz 103 16 by by IN cord-328289-3h3kmjlz 103 17 BBB BBB NNP cord-328289-3h3kmjlz 103 18 dysfunction dysfunction NN cord-328289-3h3kmjlz 103 19 and and CC cord-328289-3h3kmjlz 103 20 neurovascular neurovascular JJ cord-328289-3h3kmjlz 103 21 inflammation inflammation NN cord-328289-3h3kmjlz 103 22 ( ( -LRB- cord-328289-3h3kmjlz 103 23 Dantzer Dantzer NNP cord-328289-3h3kmjlz 103 24 , , , cord-328289-3h3kmjlz 103 25 2018 2018 CD cord-328289-3h3kmjlz 103 26 ) ) -RRB- cord-328289-3h3kmjlz 103 27 . . . cord-328289-3h3kmjlz 104 1 As as IN cord-328289-3h3kmjlz 104 2 mentioned mention VBN cord-328289-3h3kmjlz 104 3 above above RB cord-328289-3h3kmjlz 104 4 , , , cord-328289-3h3kmjlz 104 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 104 6 is be VBZ cord-328289-3h3kmjlz 104 7 associated associate VBN cord-328289-3h3kmjlz 104 8 with with IN cord-328289-3h3kmjlz 104 9 immunosuppression immunosuppression NN cord-328289-3h3kmjlz 104 10 and and CC cord-328289-3h3kmjlz 104 11 lymphopenia lymphopenia NNP cord-328289-3h3kmjlz 104 12 . . . cord-328289-3h3kmjlz 105 1 In in IN cord-328289-3h3kmjlz 105 2 stroke stroke NN cord-328289-3h3kmjlz 105 3 and and CC cord-328289-3h3kmjlz 105 4 brain brain NN cord-328289-3h3kmjlz 105 5 trauma trauma NN cord-328289-3h3kmjlz 105 6 adrenergic adrenergic NN cord-328289-3h3kmjlz 105 7 stress stress NN cord-328289-3h3kmjlz 105 8 involving involve VBG cord-328289-3h3kmjlz 105 9 βadrenergic βadrenergic NNP cord-328289-3h3kmjlz 105 10 receptors receptor NNS cord-328289-3h3kmjlz 105 11 results result NNS cord-328289-3h3kmjlz 105 12 in in IN cord-328289-3h3kmjlz 105 13 massive massive JJ cord-328289-3h3kmjlz 105 14 systemic systemic JJ cord-328289-3h3kmjlz 105 15 immunosuppression immunosuppression NN cord-328289-3h3kmjlz 105 16 . . . cord-328289-3h3kmjlz 106 1 The the DT cord-328289-3h3kmjlz 106 2 mechanisms mechanism NNS cord-328289-3h3kmjlz 106 3 of of IN cord-328289-3h3kmjlz 106 4 these these DT cord-328289-3h3kmjlz 106 5 effects effect NNS cord-328289-3h3kmjlz 106 6 involve involve VBP cord-328289-3h3kmjlz 106 7 activation activation NN cord-328289-3h3kmjlz 106 8 of of IN cord-328289-3h3kmjlz 106 9 the the DT cord-328289-3h3kmjlz 106 10 HPA HPA NNP cord-328289-3h3kmjlz 106 11 , , , cord-328289-3h3kmjlz 106 12 leading lead VBG cord-328289-3h3kmjlz 106 13 to to IN cord-328289-3h3kmjlz 106 14 the the DT cord-328289-3h3kmjlz 106 15 release release NN cord-328289-3h3kmjlz 106 16 of of IN cord-328289-3h3kmjlz 106 17 norepinephrine norepinephrine NN cord-328289-3h3kmjlz 106 18 and and CC cord-328289-3h3kmjlz 106 19 glucocorticoids glucocorticoid NNS cord-328289-3h3kmjlz 106 20 . . . cord-328289-3h3kmjlz 107 1 These these DT cord-328289-3h3kmjlz 107 2 mediators mediator NNS cord-328289-3h3kmjlz 107 3 act act VBP cord-328289-3h3kmjlz 107 4 synergistically synergistically RB cord-328289-3h3kmjlz 107 5 to to TO cord-328289-3h3kmjlz 107 6 induce induce VB cord-328289-3h3kmjlz 107 7 splenic splenic JJ cord-328289-3h3kmjlz 107 8 atrophy atrophy NN cord-328289-3h3kmjlz 107 9 , , , cord-328289-3h3kmjlz 107 10 T t NN cord-328289-3h3kmjlz 107 11 cell cell NN cord-328289-3h3kmjlz 107 12 apoptosis apoptosis NN cord-328289-3h3kmjlz 107 13 , , , cord-328289-3h3kmjlz 107 14 and and CC cord-328289-3h3kmjlz 107 15 NK NK NNP cord-328289-3h3kmjlz 107 16 cell cell NN cord-328289-3h3kmjlz 107 17 deficiency deficiency NN cord-328289-3h3kmjlz 107 18 . . . cord-328289-3h3kmjlz 108 1 In in IN cord-328289-3h3kmjlz 108 2 the the DT cord-328289-3h3kmjlz 108 3 bone bone NN cord-328289-3h3kmjlz 108 4 marrow marrow NN cord-328289-3h3kmjlz 108 5 , , , cord-328289-3h3kmjlz 108 6 tyrosine tyrosine NN cord-328289-3h3kmjlz 108 7 hydroxylase hydroxylase NN cord-328289-3h3kmjlz 108 8 and and CC cord-328289-3h3kmjlz 108 9 norepinephrine norepinephrine NN cord-328289-3h3kmjlz 108 10 trigger trigger NN cord-328289-3h3kmjlz 108 11 a a DT cord-328289-3h3kmjlz 108 12 response response NN cord-328289-3h3kmjlz 108 13 in in IN cord-328289-3h3kmjlz 108 14 mesenchymal mesenchymal JJ cord-328289-3h3kmjlz 108 15 stromal stromal JJ cord-328289-3h3kmjlz 108 16 cells cell NNS cord-328289-3h3kmjlz 108 17 , , , cord-328289-3h3kmjlz 108 18 most most RBS cord-328289-3h3kmjlz 108 19 likely likely JJ cord-328289-3h3kmjlz 108 20 through through IN cord-328289-3h3kmjlz 108 21 β3adrenergic β3adrenergic NNP cord-328289-3h3kmjlz 108 22 receptors receptor NNS cord-328289-3h3kmjlz 108 23 , , , cord-328289-3h3kmjlz 108 24 resulting result VBG cord-328289-3h3kmjlz 108 25 in in IN cord-328289-3h3kmjlz 108 26 a a DT cord-328289-3h3kmjlz 108 27 reduction reduction NN cord-328289-3h3kmjlz 108 28 of of IN cord-328289-3h3kmjlz 108 29 cell cell NN cord-328289-3h3kmjlz 108 30 retention retention NN cord-328289-3h3kmjlz 108 31 . . . cord-328289-3h3kmjlz 109 1 Downregulation Downregulation NNP cord-328289-3h3kmjlz 109 2 of of IN cord-328289-3h3kmjlz 109 3 these these DT cord-328289-3h3kmjlz 109 4 factors factor NNS cord-328289-3h3kmjlz 109 5 , , , cord-328289-3h3kmjlz 109 6 in in IN cord-328289-3h3kmjlz 109 7 concert concert NN cord-328289-3h3kmjlz 109 8 with with IN cord-328289-3h3kmjlz 109 9 calprotectin calprotectin NNP cord-328289-3h3kmjlz 109 10 release release NN cord-328289-3h3kmjlz 109 11 from from IN cord-328289-3h3kmjlz 109 12 damaged damaged JJ cord-328289-3h3kmjlz 109 13 lungs lung NNS cord-328289-3h3kmjlz 109 14 , , , cord-328289-3h3kmjlz 109 15 may may MD cord-328289-3h3kmjlz 109 16 increases increase VBZ cord-328289-3h3kmjlz 109 17 hematopoietic hematopoietic JJ cord-328289-3h3kmjlz 109 18 stem stem NN cord-328289-3h3kmjlz 109 19 cell cell NN cord-328289-3h3kmjlz 109 20 proliferation proliferation NN cord-328289-3h3kmjlz 109 21 skewed skewed JJ cord-328289-3h3kmjlz 109 22 towards towards IN cord-328289-3h3kmjlz 109 23 the the DT cord-328289-3h3kmjlz 109 24 myeloid myeloid JJ cord-328289-3h3kmjlz 109 25 lineage lineage NN cord-328289-3h3kmjlz 109 26 ( ( -LRB- cord-328289-3h3kmjlz 109 27 emergency emergency NN cord-328289-3h3kmjlz 109 28 myelopoiesis myelopoiesis NN cord-328289-3h3kmjlz 109 29 ) ) -RRB- cord-328289-3h3kmjlz 110 1 ( ( -LRB- cord-328289-3h3kmjlz 110 2 Schulte Schulte NNP cord-328289-3h3kmjlz 110 3 - - HYPH cord-328289-3h3kmjlz 110 4 Schrepping Schrepping NNP cord-328289-3h3kmjlz 110 5 et et FW cord-328289-3h3kmjlz 110 6 al al NNP cord-328289-3h3kmjlz 110 7 . . . cord-328289-3h3kmjlz 111 1 , , , cord-328289-3h3kmjlz 111 2 2020 2020 CD cord-328289-3h3kmjlz 111 3 ; ; : cord-328289-3h3kmjlz 111 4 Silvin Silvin NNP cord-328289-3h3kmjlz 111 5 et et NNP cord-328289-3h3kmjlz 111 6 al al NNP cord-328289-3h3kmjlz 111 7 . . NNP cord-328289-3h3kmjlz 111 8 , , , cord-328289-3h3kmjlz 111 9 2020 2020 CD cord-328289-3h3kmjlz 111 10 ) ) -RRB- cord-328289-3h3kmjlz 111 11 , , , cord-328289-3h3kmjlz 111 12 which which WDT cord-328289-3h3kmjlz 111 13 results result VBZ cord-328289-3h3kmjlz 111 14 in in IN cord-328289-3h3kmjlz 111 15 lymphopenia lymphopenia NNP cord-328289-3h3kmjlz 111 16 and and CC cord-328289-3h3kmjlz 111 17 neutrophilia neutrophilia NNP cord-328289-3h3kmjlz 111 18 , , , cord-328289-3h3kmjlz 111 19 two two CD cord-328289-3h3kmjlz 111 20 key key JJ cord-328289-3h3kmjlz 111 21 hematological hematological JJ cord-328289-3h3kmjlz 111 22 features feature NNS cord-328289-3h3kmjlz 111 23 of of IN cord-328289-3h3kmjlz 111 24 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 111 25 ( ( -LRB- cord-328289-3h3kmjlz 111 26 Chen Chen NNP cord-328289-3h3kmjlz 111 27 et et NNP cord-328289-3h3kmjlz 111 28 al al NNP cord-328289-3h3kmjlz 111 29 . . . cord-328289-3h3kmjlz 112 1 , , , cord-328289-3h3kmjlz 112 2 2020a 2020a CD cord-328289-3h3kmjlz 112 3 ; ; : cord-328289-3h3kmjlz 112 4 Moriguchi Moriguchi NNP cord-328289-3h3kmjlz 112 5 et et NNP cord-328289-3h3kmjlz 112 6 al al NNP cord-328289-3h3kmjlz 112 7 . . NNP cord-328289-3h3kmjlz 112 8 , , , cord-328289-3h3kmjlz 112 9 2020 2020 CD cord-328289-3h3kmjlz 113 1 ; ; : cord-328289-3h3kmjlz 113 2 Qin Qin NNP cord-328289-3h3kmjlz 113 3 et et FW cord-328289-3h3kmjlz 113 4 al al NNP cord-328289-3h3kmjlz 113 5 . . NNP cord-328289-3h3kmjlz 113 6 , , , cord-328289-3h3kmjlz 113 7 2020 2020 CD cord-328289-3h3kmjlz 113 8 ) ) -RRB- cord-328289-3h3kmjlz 114 1 ( ( -LRB- cord-328289-3h3kmjlz 114 2 Figure figure NN cord-328289-3h3kmjlz 114 3 3 3 CD cord-328289-3h3kmjlz 114 4 ) ) -RRB- cord-328289-3h3kmjlz 114 5 . . . cord-328289-3h3kmjlz 115 1 Importantly importantly RB cord-328289-3h3kmjlz 115 2 , , , cord-328289-3h3kmjlz 115 3 in in IN cord-328289-3h3kmjlz 115 4 SARS SARS NNP cord-328289-3h3kmjlz 115 5 , , , cord-328289-3h3kmjlz 115 6 HPA HPA NNP cord-328289-3h3kmjlz 115 7 activation activation NN cord-328289-3h3kmjlz 115 8 and and CC cord-328289-3h3kmjlz 115 9 glucocorticoid glucocorticoid NN cord-328289-3h3kmjlz 115 10 levels level NNS cord-328289-3h3kmjlz 115 11 are be VBP cord-328289-3h3kmjlz 115 12 correlated correlate VBN cord-328289-3h3kmjlz 115 13 with with IN cord-328289-3h3kmjlz 115 14 neutrophilia neutrophilia NNP cord-328289-3h3kmjlz 115 15 and and CC cord-328289-3h3kmjlz 115 16 lymphopenia lymphopenia NNP cord-328289-3h3kmjlz 115 17 ( ( -LRB- cord-328289-3h3kmjlz 115 18 Panesar Panesar NNP cord-328289-3h3kmjlz 115 19 et et NNP cord-328289-3h3kmjlz 115 20 al al NNP cord-328289-3h3kmjlz 115 21 . . NNP cord-328289-3h3kmjlz 115 22 , , , cord-328289-3h3kmjlz 115 23 2004 2004 CD cord-328289-3h3kmjlz 115 24 ) ) -RRB- cord-328289-3h3kmjlz 115 25 . . . cord-328289-3h3kmjlz 116 1 Hypercoagulable hypercoagulable JJ cord-328289-3h3kmjlz 116 2 state state NN cord-328289-3h3kmjlz 116 3 : : : cord-328289-3h3kmjlz 117 1 Another another DT cord-328289-3h3kmjlz 117 2 key key JJ cord-328289-3h3kmjlz 117 3 feature feature NN cord-328289-3h3kmjlz 117 4 of of IN cord-328289-3h3kmjlz 117 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 117 6 is be VBZ cord-328289-3h3kmjlz 117 7 a a DT cord-328289-3h3kmjlz 117 8 profound profound JJ cord-328289-3h3kmjlz 117 9 coagulopathy coagulopathy NN cord-328289-3h3kmjlz 117 10 responsible responsible JJ cord-328289-3h3kmjlz 117 11 for for IN cord-328289-3h3kmjlz 117 12 some some DT cord-328289-3h3kmjlz 117 13 of of IN cord-328289-3h3kmjlz 117 14 the the DT cord-328289-3h3kmjlz 117 15 most most RBS cord-328289-3h3kmjlz 117 16 frequent frequent JJ cord-328289-3h3kmjlz 117 17 and and CC cord-328289-3h3kmjlz 117 18 harmful harmful JJ cord-328289-3h3kmjlz 117 19 complications complication NNS cord-328289-3h3kmjlz 117 20 of of IN cord-328289-3h3kmjlz 117 21 the the DT cord-328289-3h3kmjlz 117 22 disease disease NN cord-328289-3h3kmjlz 117 23 . . . cord-328289-3h3kmjlz 118 1 In in IN cord-328289-3h3kmjlz 118 2 a a DT cord-328289-3h3kmjlz 118 3 multicenter multicenter JJ cord-328289-3h3kmjlz 118 4 study study NN cord-328289-3h3kmjlz 118 5 , , , cord-328289-3h3kmjlz 118 6 88 88 CD cord-328289-3h3kmjlz 118 7 % % NN cord-328289-3h3kmjlz 118 8 of of IN cord-328289-3h3kmjlz 118 9 patients patient NNS cord-328289-3h3kmjlz 118 10 exhibited exhibit VBD cord-328289-3h3kmjlz 118 11 evidence evidence NN cord-328289-3h3kmjlz 118 12 of of IN cord-328289-3h3kmjlz 118 13 a a DT cord-328289-3h3kmjlz 118 14 hypercoagulable hypercoagulable JJ cord-328289-3h3kmjlz 118 15 state state NN cord-328289-3h3kmjlz 118 16 ( ( -LRB- cord-328289-3h3kmjlz 118 17 Helms Helms NNP cord-328289-3h3kmjlz 118 18 et et NNP cord-328289-3h3kmjlz 118 19 al al NNP cord-328289-3h3kmjlz 118 20 . . NNP cord-328289-3h3kmjlz 118 21 , , , cord-328289-3h3kmjlz 118 22 2020b 2020b CD cord-328289-3h3kmjlz 118 23 ) ) -RRB- cord-328289-3h3kmjlz 118 24 . . . cord-328289-3h3kmjlz 119 1 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 119 2 coagulopathy coagulopathy NNP cord-328289-3h3kmjlz 119 3 is be VBZ cord-328289-3h3kmjlz 119 4 characterized characterize VBN cord-328289-3h3kmjlz 119 5 by by IN cord-328289-3h3kmjlz 119 6 a a DT cord-328289-3h3kmjlz 119 7 distinctive distinctive JJ cord-328289-3h3kmjlz 119 8 pro pro JJ cord-328289-3h3kmjlz 119 9 - - JJ cord-328289-3h3kmjlz 119 10 coagulant coagulant JJ cord-328289-3h3kmjlz 119 11 state state NN cord-328289-3h3kmjlz 119 12 with with IN cord-328289-3h3kmjlz 119 13 increased increase VBN cord-328289-3h3kmjlz 119 14 cloth cloth NN cord-328289-3h3kmjlz 119 15 strength strength NN cord-328289-3h3kmjlz 119 16 , , , cord-328289-3h3kmjlz 119 17 increased increase VBN cord-328289-3h3kmjlz 119 18 D d NN cord-328289-3h3kmjlz 119 19 - - HYPH cord-328289-3h3kmjlz 119 20 dimers dimer NNS cord-328289-3h3kmjlz 119 21 ( ( -LRB- cord-328289-3h3kmjlz 119 22 fibrin fibrin NN cord-328289-3h3kmjlz 119 23 breakdown breakdown NN cord-328289-3h3kmjlz 119 24 products product NNS cord-328289-3h3kmjlz 119 25 indicative indicative JJ cord-328289-3h3kmjlz 119 26 of of IN cord-328289-3h3kmjlz 119 27 intravascular intravascular JJ cord-328289-3h3kmjlz 119 28 thrombosis thrombosis NN cord-328289-3h3kmjlz 119 29 ) ) -RRB- cord-328289-3h3kmjlz 119 30 , , , cord-328289-3h3kmjlz 119 31 and and CC cord-328289-3h3kmjlz 119 32 increased increase VBN cord-328289-3h3kmjlz 119 33 fibrinogen fibrinogen NN cord-328289-3h3kmjlz 119 34 , , , cord-328289-3h3kmjlz 119 35 without without IN cord-328289-3h3kmjlz 119 36 significant significant JJ cord-328289-3h3kmjlz 119 37 changes change NNS cord-328289-3h3kmjlz 119 38 in in IN cord-328289-3h3kmjlz 119 39 the the DT cord-328289-3h3kmjlz 119 40 number number NN cord-328289-3h3kmjlz 119 41 of of IN cord-328289-3h3kmjlz 119 42 platelets platelet NNS cord-328289-3h3kmjlz 119 43 or or CC cord-328289-3h3kmjlz 119 44 prolongation prolongation NN cord-328289-3h3kmjlz 119 45 of of IN cord-328289-3h3kmjlz 119 46 clotting clot VBG cord-328289-3h3kmjlz 119 47 time time NN cord-328289-3h3kmjlz 119 48 parameters parameter NNS cord-328289-3h3kmjlz 119 49 ( ( -LRB- cord-328289-3h3kmjlz 119 50 Helms Helms NNP cord-328289-3h3kmjlz 119 51 et et NNP cord-328289-3h3kmjlz 119 52 al al NNP cord-328289-3h3kmjlz 119 53 . . NNP cord-328289-3h3kmjlz 119 54 , , , cord-328289-3h3kmjlz 119 55 2020b 2020b CD cord-328289-3h3kmjlz 119 56 ) ) -RRB- cord-328289-3h3kmjlz 119 57 . . . cord-328289-3h3kmjlz 120 1 Coagulopathy Coagulopathy NNP cord-328289-3h3kmjlz 120 2 and and CC cord-328289-3h3kmjlz 120 3 thrombosis thrombosis NN cord-328289-3h3kmjlz 120 4 may may MD cord-328289-3h3kmjlz 120 5 start start VB cord-328289-3h3kmjlz 120 6 in in IN cord-328289-3h3kmjlz 120 7 the the DT cord-328289-3h3kmjlz 120 8 lungs lung NNS cord-328289-3h3kmjlz 120 9 and and CC cord-328289-3h3kmjlz 120 10 other other JJ cord-328289-3h3kmjlz 120 11 infected infected JJ cord-328289-3h3kmjlz 120 12 organs organ NNS cord-328289-3h3kmjlz 120 13 with with IN cord-328289-3h3kmjlz 120 14 endothelial endothelial JJ cord-328289-3h3kmjlz 120 15 damage damage NN cord-328289-3h3kmjlz 120 16 , , , cord-328289-3h3kmjlz 120 17 complement complement NN cord-328289-3h3kmjlz 120 18 activation activation NN cord-328289-3h3kmjlz 120 19 , , , cord-328289-3h3kmjlz 120 20 the the DT cord-328289-3h3kmjlz 120 21 procoagulant procoagulant JJ cord-328289-3h3kmjlz 120 22 action action NN cord-328289-3h3kmjlz 120 23 of of IN cord-328289-3h3kmjlz 120 24 IL-6 IL-6 NNP cord-328289-3h3kmjlz 120 25 , , , cord-328289-3h3kmjlz 120 26 and and CC cord-328289-3h3kmjlz 120 27 neutrophil neutrophil NN cord-328289-3h3kmjlz 120 28 recruitment recruitment NN cord-328289-3h3kmjlz 120 29 ( ( -LRB- cord-328289-3h3kmjlz 120 30 Goshua Goshua NNP cord-328289-3h3kmjlz 120 31 et et NNP cord-328289-3h3kmjlz 120 32 al al NNP cord-328289-3h3kmjlz 120 33 . . . cord-328289-3h3kmjlz 121 1 , , , cord-328289-3h3kmjlz 121 2 2020 2020 CD cord-328289-3h3kmjlz 121 3 ; ; : cord-328289-3h3kmjlz 121 4 Ramlall Ramlall NNP cord-328289-3h3kmjlz 121 5 et et NNP cord-328289-3h3kmjlz 121 6 al al NNP cord-328289-3h3kmjlz 121 7 . . NNP cord-328289-3h3kmjlz 121 8 , , , cord-328289-3h3kmjlz 121 9 2020 2020 CD cord-328289-3h3kmjlz 121 10 ) ) -RRB- cord-328289-3h3kmjlz 121 11 . . . cord-328289-3h3kmjlz 122 1 In in IN cord-328289-3h3kmjlz 122 2 turn turn NN cord-328289-3h3kmjlz 122 3 , , , cord-328289-3h3kmjlz 122 4 neutrophils neutrophil NNS cord-328289-3h3kmjlz 122 5 release release VBP cord-328289-3h3kmjlz 122 6 extracellular extracellular JJ cord-328289-3h3kmjlz 122 7 traps trap NNS cord-328289-3h3kmjlz 122 8 ( ( -LRB- cord-328289-3h3kmjlz 122 9 NETs NETs NNP cord-328289-3h3kmjlz 122 10 ) ) -RRB- cord-328289-3h3kmjlz 122 11 in in IN cord-328289-3h3kmjlz 122 12 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 122 13 ( ( -LRB- cord-328289-3h3kmjlz 122 14 Middleton Middleton NNP cord-328289-3h3kmjlz 122 15 et et NNP cord-328289-3h3kmjlz 122 16 al al NNP cord-328289-3h3kmjlz 122 17 . . NNP cord-328289-3h3kmjlz 122 18 , , , cord-328289-3h3kmjlz 122 19 2020 2020 CD cord-328289-3h3kmjlz 122 20 ) ) -RRB- cord-328289-3h3kmjlz 122 21 , , , cord-328289-3h3kmjlz 122 22 a a DT cord-328289-3h3kmjlz 122 23 lattice lattice NN cord-328289-3h3kmjlz 122 24 of of IN cord-328289-3h3kmjlz 122 25 chromatin chromatin NN cord-328289-3h3kmjlz 122 26 and and CC cord-328289-3h3kmjlz 122 27 histones histone NNS cord-328289-3h3kmjlz 122 28 that that WDT cord-328289-3h3kmjlz 122 29 activates activate VBZ cord-328289-3h3kmjlz 122 30 clotting clotting NN cord-328289-3h3kmjlz 122 31 , , , cord-328289-3h3kmjlz 122 32 which which WDT cord-328289-3h3kmjlz 122 33 contributes contribute VBZ cord-328289-3h3kmjlz 122 34 to to IN cord-328289-3h3kmjlz 122 35 intravascular intravascular JJ cord-328289-3h3kmjlz 122 36 thrombosis thrombosis NN cord-328289-3h3kmjlz 122 37 by by IN cord-328289-3h3kmjlz 122 38 trapping trap VBG cord-328289-3h3kmjlz 122 39 cells cell NNS cord-328289-3h3kmjlz 122 40 and and CC cord-328289-3h3kmjlz 122 41 platelets platelet NNS cord-328289-3h3kmjlz 122 42 in in IN cord-328289-3h3kmjlz 122 43 many many JJ cord-328289-3h3kmjlz 122 44 organs organ NNS cord-328289-3h3kmjlz 122 45 including include VBG cord-328289-3h3kmjlz 122 46 the the DT cord-328289-3h3kmjlz 122 47 brain brain NN cord-328289-3h3kmjlz 122 48 . . . cord-328289-3h3kmjlz 123 1 Systemic systemic JJ cord-328289-3h3kmjlz 123 2 organ organ NN cord-328289-3h3kmjlz 123 3 failure failure NN cord-328289-3h3kmjlz 123 4 : : : cord-328289-3h3kmjlz 123 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 123 6 also also RB cord-328289-3h3kmjlz 123 7 damages damage VBZ cord-328289-3h3kmjlz 123 8 other other JJ cord-328289-3h3kmjlz 123 9 organs organ NNS cord-328289-3h3kmjlz 123 10 . . . cord-328289-3h3kmjlz 124 1 Metabolic metabolic JJ cord-328289-3h3kmjlz 124 2 and and CC cord-328289-3h3kmjlz 124 3 pathological pathological JJ cord-328289-3h3kmjlz 124 4 evidence evidence NN cord-328289-3h3kmjlz 124 5 of of IN cord-328289-3h3kmjlz 124 6 damage damage NN cord-328289-3h3kmjlz 124 7 to to IN cord-328289-3h3kmjlz 124 8 the the DT cord-328289-3h3kmjlz 124 9 kidney kidney NN cord-328289-3h3kmjlz 124 10 , , , cord-328289-3h3kmjlz 124 11 heart heart NN cord-328289-3h3kmjlz 124 12 , , , cord-328289-3h3kmjlz 124 13 liver liver NN cord-328289-3h3kmjlz 124 14 , , , cord-328289-3h3kmjlz 124 15 gastrointestinal gastrointestinal JJ cord-328289-3h3kmjlz 124 16 tract tract NN cord-328289-3h3kmjlz 124 17 , , , cord-328289-3h3kmjlz 124 18 and and CC cord-328289-3h3kmjlz 124 19 endocrine endocrine JJ cord-328289-3h3kmjlz 124 20 organs organ NNS cord-328289-3h3kmjlz 124 21 has have VBZ cord-328289-3h3kmjlz 124 22 been be VBN cord-328289-3h3kmjlz 124 23 provided provide VBN cord-328289-3h3kmjlz 124 24 Inciardi Inciardi NNP cord-328289-3h3kmjlz 124 25 et et NNP cord-328289-3h3kmjlz 124 26 al al NNP cord-328289-3h3kmjlz 124 27 . . NNP cord-328289-3h3kmjlz 124 28 , , , cord-328289-3h3kmjlz 124 29 2020 2020 CD cord-328289-3h3kmjlz 124 30 ; ; : cord-328289-3h3kmjlz 124 31 Pal Pal NNP cord-328289-3h3kmjlz 124 32 and and CC cord-328289-3h3kmjlz 124 33 Banerjee Banerjee NNP cord-328289-3h3kmjlz 124 34 , , , cord-328289-3h3kmjlz 124 35 2020 2020 CD cord-328289-3h3kmjlz 124 36 ; ; : cord-328289-3h3kmjlz 124 37 Pan Pan NNP cord-328289-3h3kmjlz 124 38 et et NNP cord-328289-3h3kmjlz 124 39 al al NNP cord-328289-3h3kmjlz 124 40 . . NNP cord-328289-3h3kmjlz 124 41 , , , cord-328289-3h3kmjlz 124 42 2020 2020 CD cord-328289-3h3kmjlz 124 43 ; ; : cord-328289-3h3kmjlz 124 44 Su Su NNP cord-328289-3h3kmjlz 124 45 et et FW cord-328289-3h3kmjlz 124 46 al al NNP cord-328289-3h3kmjlz 124 47 . . NNP cord-328289-3h3kmjlz 124 48 , , , cord-328289-3h3kmjlz 124 49 2020 2020 CD cord-328289-3h3kmjlz 124 50 ) ) -RRB- cord-328289-3h3kmjlz 124 51 . . . cord-328289-3h3kmjlz 125 1 The the DT cord-328289-3h3kmjlz 125 2 resulting result VBG cord-328289-3h3kmjlz 125 3 systemic systemic JJ cord-328289-3h3kmjlz 125 4 metabolic metabolic JJ cord-328289-3h3kmjlz 125 5 changes change NNS cord-328289-3h3kmjlz 125 6 , , , cord-328289-3h3kmjlz 125 7 including include VBG cord-328289-3h3kmjlz 125 8 water water NN cord-328289-3h3kmjlz 125 9 and and CC cord-328289-3h3kmjlz 125 10 electrolyte electrolyte JJ cord-328289-3h3kmjlz 125 11 imbalance imbalance NN cord-328289-3h3kmjlz 125 12 , , , cord-328289-3h3kmjlz 125 13 hormonal hormonal JJ cord-328289-3h3kmjlz 125 14 dysfunction dysfunction NN cord-328289-3h3kmjlz 125 15 , , , cord-328289-3h3kmjlz 125 16 and and CC cord-328289-3h3kmjlz 125 17 accumulation accumulation NN cord-328289-3h3kmjlz 125 18 of of IN cord-328289-3h3kmjlz 125 19 toxic toxic JJ cord-328289-3h3kmjlz 125 20 metabolites metabolite NNS cord-328289-3h3kmjlz 125 21 , , , cord-328289-3h3kmjlz 125 22 could could MD cord-328289-3h3kmjlz 125 23 also also RB cord-328289-3h3kmjlz 125 24 contribute contribute VB cord-328289-3h3kmjlz 125 25 to to IN cord-328289-3h3kmjlz 125 26 some some DT cord-328289-3h3kmjlz 125 27 of of IN cord-328289-3h3kmjlz 125 28 the the DT cord-328289-3h3kmjlz 125 29 more more RBR cord-328289-3h3kmjlz 125 30 non non JJ cord-328289-3h3kmjlz 125 31 - - JJ cord-328289-3h3kmjlz 125 32 specific specific JJ cord-328289-3h3kmjlz 125 33 nervous nervous JJ cord-328289-3h3kmjlz 125 34 system system NN cord-328289-3h3kmjlz 125 35 manifestations manifestation NNS cord-328289-3h3kmjlz 125 36 of of IN cord-328289-3h3kmjlz 125 37 the the DT cord-328289-3h3kmjlz 125 38 disease disease NN cord-328289-3h3kmjlz 125 39 , , , cord-328289-3h3kmjlz 125 40 like like IN cord-328289-3h3kmjlz 125 41 confusion confusion NN cord-328289-3h3kmjlz 125 42 , , , cord-328289-3h3kmjlz 125 43 agitation agitation NN cord-328289-3h3kmjlz 125 44 , , , cord-328289-3h3kmjlz 125 45 headache headache NN cord-328289-3h3kmjlz 125 46 etc etc FW cord-328289-3h3kmjlz 125 47 . . . cord-328289-3h3kmjlz 126 1 Cardiac cardiac JJ cord-328289-3h3kmjlz 126 2 involvement involvement NN cord-328289-3h3kmjlz 126 3 could could MD cord-328289-3h3kmjlz 126 4 impact impact VB cord-328289-3h3kmjlz 126 5 the the DT cord-328289-3h3kmjlz 126 6 brain brain NN cord-328289-3h3kmjlz 126 7 by by IN cord-328289-3h3kmjlz 126 8 reducing reduce VBG cord-328289-3h3kmjlz 126 9 cerebral cerebral JJ cord-328289-3h3kmjlz 126 10 perfusion perfusion NN cord-328289-3h3kmjlz 126 11 or or CC cord-328289-3h3kmjlz 126 12 , , , cord-328289-3h3kmjlz 126 13 as as IN cord-328289-3h3kmjlz 126 14 discussed discuss VBN cord-328289-3h3kmjlz 126 15 in in IN cord-328289-3h3kmjlz 126 16 the the DT cord-328289-3h3kmjlz 126 17 next next JJ cord-328289-3h3kmjlz 126 18 section section NN cord-328289-3h3kmjlz 126 19 , , , cord-328289-3h3kmjlz 126 20 could could MD cord-328289-3h3kmjlz 126 21 be be VB cord-328289-3h3kmjlz 126 22 an an DT cord-328289-3h3kmjlz 126 23 embolic embolic JJ cord-328289-3h3kmjlz 126 24 source source NN cord-328289-3h3kmjlz 126 25 leading lead VBG cord-328289-3h3kmjlz 126 26 to to IN cord-328289-3h3kmjlz 126 27 ischemic ischemic JJ cord-328289-3h3kmjlz 126 28 strokes stroke NNS cord-328289-3h3kmjlz 126 29 . . . cord-328289-3h3kmjlz 127 1 Numerous numerous JJ cord-328289-3h3kmjlz 127 2 neurological neurological JJ cord-328289-3h3kmjlz 127 3 abnormalities abnormality NNS cord-328289-3h3kmjlz 127 4 have have VBP cord-328289-3h3kmjlz 127 5 been be VBN cord-328289-3h3kmjlz 127 6 described describe VBN cord-328289-3h3kmjlz 127 7 in in IN cord-328289-3h3kmjlz 127 8 patients patient NNS cord-328289-3h3kmjlz 127 9 with with IN cord-328289-3h3kmjlz 127 10 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 127 11 . . . cord-328289-3h3kmjlz 128 1 These these DT cord-328289-3h3kmjlz 128 2 involve involve VBP cord-328289-3h3kmjlz 128 3 the the DT cord-328289-3h3kmjlz 128 4 central central JJ cord-328289-3h3kmjlz 128 5 and and CC cord-328289-3h3kmjlz 128 6 peripheral peripheral JJ cord-328289-3h3kmjlz 128 7 nervous nervous JJ cord-328289-3h3kmjlz 128 8 system system NN cord-328289-3h3kmjlz 128 9 , , , cord-328289-3h3kmjlz 128 10 range range VBP cord-328289-3h3kmjlz 128 11 from from IN cord-328289-3h3kmjlz 128 12 mild mild JJ cord-328289-3h3kmjlz 128 13 to to IN cord-328289-3h3kmjlz 128 14 fatal fatal JJ cord-328289-3h3kmjlz 128 15 , , , cord-328289-3h3kmjlz 128 16 and and CC cord-328289-3h3kmjlz 128 17 can can MD cord-328289-3h3kmjlz 128 18 occur occur VB cord-328289-3h3kmjlz 128 19 in in IN cord-328289-3h3kmjlz 128 20 patients patient NNS cord-328289-3h3kmjlz 128 21 with with IN cord-328289-3h3kmjlz 128 22 severe severe JJ cord-328289-3h3kmjlz 128 23 or or CC cord-328289-3h3kmjlz 128 24 otherwise otherwise RB cord-328289-3h3kmjlz 128 25 asymptomatic asymptomatic JJ cord-328289-3h3kmjlz 128 26 SARS SARS NNP cord-328289-3h3kmjlz 128 27 - - HYPH cord-328289-3h3kmjlz 128 28 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 128 29 infection infection NN cord-328289-3h3kmjlz 128 30 . . . cord-328289-3h3kmjlz 129 1 Neurological neurological JJ cord-328289-3h3kmjlz 129 2 abnormalities abnormality NNS cord-328289-3h3kmjlz 129 3 have have VBP cord-328289-3h3kmjlz 129 4 been be VBN cord-328289-3h3kmjlz 129 5 described describe VBN cord-328289-3h3kmjlz 129 6 in in IN cord-328289-3h3kmjlz 129 7 approximately approximately RB cord-328289-3h3kmjlz 129 8 30 30 CD cord-328289-3h3kmjlz 129 9 % % NN cord-328289-3h3kmjlz 129 10 of of IN cord-328289-3h3kmjlz 129 11 patients patient NNS cord-328289-3h3kmjlz 129 12 who who WP cord-328289-3h3kmjlz 129 13 required require VBD cord-328289-3h3kmjlz 129 14 hospitalization hospitalization NN cord-328289-3h3kmjlz 129 15 for for IN cord-328289-3h3kmjlz 129 16 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 129 17 , , , cord-328289-3h3kmjlz 129 18 45 45 CD cord-328289-3h3kmjlz 129 19 % % NN cord-328289-3h3kmjlz 129 20 of of IN cord-328289-3h3kmjlz 129 21 those those DT cord-328289-3h3kmjlz 129 22 with with IN cord-328289-3h3kmjlz 129 23 severe severe JJ cord-328289-3h3kmjlz 129 24 respiratory respiratory JJ cord-328289-3h3kmjlz 129 25 illness illness NN cord-328289-3h3kmjlz 129 26 , , , cord-328289-3h3kmjlz 129 27 and and CC cord-328289-3h3kmjlz 129 28 85 85 CD cord-328289-3h3kmjlz 129 29 % % NN cord-328289-3h3kmjlz 129 30 of of IN cord-328289-3h3kmjlz 129 31 those those DT cord-328289-3h3kmjlz 129 32 with with IN cord-328289-3h3kmjlz 129 33 ARDS ARDS NNP cord-328289-3h3kmjlz 129 34 ( ( -LRB- cord-328289-3h3kmjlz 129 35 Helms Helms NNP cord-328289-3h3kmjlz 129 36 et et NNP cord-328289-3h3kmjlz 129 37 al al NNP cord-328289-3h3kmjlz 129 38 . . NNP cord-328289-3h3kmjlz 129 39 , , , cord-328289-3h3kmjlz 129 40 2020a 2020a CD cord-328289-3h3kmjlz 129 41 ; ; : cord-328289-3h3kmjlz 129 42 Mao Mao NNP cord-328289-3h3kmjlz 129 43 et et NNP cord-328289-3h3kmjlz 129 44 al al NNP cord-328289-3h3kmjlz 129 45 . . NNP cord-328289-3h3kmjlz 129 46 , , , cord-328289-3h3kmjlz 129 47 2020 2020 CD cord-328289-3h3kmjlz 129 48 ) ) -RRB- cord-328289-3h3kmjlz 129 49 . . . cord-328289-3h3kmjlz 130 1 In in IN cord-328289-3h3kmjlz 130 2 patients patient NNS cord-328289-3h3kmjlz 130 3 with with IN cord-328289-3h3kmjlz 130 4 mild mild JJ cord-328289-3h3kmjlz 130 5 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 130 6 neurological neurological JJ cord-328289-3h3kmjlz 130 7 symptoms symptom NNS cord-328289-3h3kmjlz 130 8 are be VBP cord-328289-3h3kmjlz 130 9 mostly mostly RB cord-328289-3h3kmjlz 130 10 confined confine VBN cord-328289-3h3kmjlz 130 11 to to IN cord-328289-3h3kmjlz 130 12 nonspecific nonspecific JJ cord-328289-3h3kmjlz 130 13 abnormalities abnormality NNS cord-328289-3h3kmjlz 130 14 such such JJ cord-328289-3h3kmjlz 130 15 as as IN cord-328289-3h3kmjlz 130 16 malaise malaise NN cord-328289-3h3kmjlz 130 17 , , , cord-328289-3h3kmjlz 130 18 dizziness dizziness NN cord-328289-3h3kmjlz 130 19 , , , cord-328289-3h3kmjlz 130 20 headache headache NN cord-328289-3h3kmjlz 130 21 , , , cord-328289-3h3kmjlz 130 22 and and CC cord-328289-3h3kmjlz 130 23 loss loss NN cord-328289-3h3kmjlz 130 24 of of IN cord-328289-3h3kmjlz 130 25 smell smell NN cord-328289-3h3kmjlz 130 26 and and CC cord-328289-3h3kmjlz 130 27 taste taste NN cord-328289-3h3kmjlz 131 1 ( ( -LRB- cord-328289-3h3kmjlz 131 2 Mao Mao NNP cord-328289-3h3kmjlz 131 3 et et NNP cord-328289-3h3kmjlz 131 4 al al NNP cord-328289-3h3kmjlz 131 5 . . NNP cord-328289-3h3kmjlz 131 6 , , , cord-328289-3h3kmjlz 131 7 2020 2020 CD cord-328289-3h3kmjlz 131 8 ) ) -RRB- cord-328289-3h3kmjlz 131 9 , , , cord-328289-3h3kmjlz 131 10 routinely routinely RB cord-328289-3h3kmjlz 131 11 observed observe VBN cord-328289-3h3kmjlz 131 12 in in IN cord-328289-3h3kmjlz 131 13 respiratory respiratory JJ cord-328289-3h3kmjlz 131 14 virus virus NN cord-328289-3h3kmjlz 131 15 infections infection NNS cord-328289-3h3kmjlz 131 16 such such JJ cord-328289-3h3kmjlz 131 17 as as IN cord-328289-3h3kmjlz 131 18 the the DT cord-328289-3h3kmjlz 131 19 influenza influenza NN cord-328289-3h3kmjlz 131 20 ( ( -LRB- cord-328289-3h3kmjlz 131 21 Chow Chow NNP cord-328289-3h3kmjlz 131 22 et et FW cord-328289-3h3kmjlz 131 23 al al NNP cord-328289-3h3kmjlz 131 24 . . NNP cord-328289-3h3kmjlz 131 25 , , , cord-328289-3h3kmjlz 131 26 2019 2019 CD cord-328289-3h3kmjlz 131 27 ) ) -RRB- cord-328289-3h3kmjlz 131 28 . . . cord-328289-3h3kmjlz 132 1 While while IN cord-328289-3h3kmjlz 132 2 serious serious JJ cord-328289-3h3kmjlz 132 3 neurological neurological JJ cord-328289-3h3kmjlz 132 4 complications complication NNS cord-328289-3h3kmjlz 132 5 have have VBP cord-328289-3h3kmjlz 132 6 been be VBN cord-328289-3h3kmjlz 132 7 reported report VBN cord-328289-3h3kmjlz 132 8 in in IN cord-328289-3h3kmjlz 132 9 patients patient NNS cord-328289-3h3kmjlz 132 10 with with IN cord-328289-3h3kmjlz 132 11 otherwise otherwise RB cord-328289-3h3kmjlz 132 12 mild mild JJ cord-328289-3h3kmjlz 132 13 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 132 14 ( ( -LRB- cord-328289-3h3kmjlz 132 15 Oxley Oxley NNP cord-328289-3h3kmjlz 132 16 et et NNP cord-328289-3h3kmjlz 132 17 al al NNP cord-328289-3h3kmjlz 132 18 . . NNP cord-328289-3h3kmjlz 132 19 , , , cord-328289-3h3kmjlz 132 20 2020 2020 CD cord-328289-3h3kmjlz 132 21 ) ) -RRB- cord-328289-3h3kmjlz 132 22 , , , cord-328289-3h3kmjlz 132 23 the the DT cord-328289-3h3kmjlz 132 24 most most RBS cord-328289-3h3kmjlz 132 25 severe severe JJ cord-328289-3h3kmjlz 132 26 complications complication NNS cord-328289-3h3kmjlz 132 27 occur occur VBP cord-328289-3h3kmjlz 132 28 in in IN cord-328289-3h3kmjlz 132 29 critically critically RB cord-328289-3h3kmjlz 132 30 ill ill JJ cord-328289-3h3kmjlz 132 31 patients patient NNS cord-328289-3h3kmjlz 132 32 and and CC cord-328289-3h3kmjlz 132 33 are be VBP cord-328289-3h3kmjlz 132 34 associated associate VBN cord-328289-3h3kmjlz 132 35 with with IN cord-328289-3h3kmjlz 132 36 significantly significantly RB cord-328289-3h3kmjlz 132 37 higher high JJR cord-328289-3h3kmjlz 132 38 mortality mortality NN cord-328289-3h3kmjlz 132 39 Yaghi Yaghi NNP cord-328289-3h3kmjlz 132 40 et et FW cord-328289-3h3kmjlz 132 41 al al NNP cord-328289-3h3kmjlz 132 42 . . NNP cord-328289-3h3kmjlz 132 43 , , , cord-328289-3h3kmjlz 132 44 2020 2020 CD cord-328289-3h3kmjlz 132 45 ) ) -RRB- cord-328289-3h3kmjlz 132 46 . . . cord-328289-3h3kmjlz 133 1 Encephalopathy encephalopathy NN cord-328289-3h3kmjlz 133 2 and and CC cord-328289-3h3kmjlz 133 3 encephalitis encephalitis NN cord-328289-3h3kmjlz 133 4 : : . cord-328289-3h3kmjlz 134 1 Alterations alteration NNS cord-328289-3h3kmjlz 134 2 in in IN cord-328289-3h3kmjlz 134 3 mental mental JJ cord-328289-3h3kmjlz 134 4 status status NN cord-328289-3h3kmjlz 134 5 ( ( -LRB- cord-328289-3h3kmjlz 134 6 confusion confusion NN cord-328289-3h3kmjlz 134 7 , , , cord-328289-3h3kmjlz 134 8 disorientation disorientation NN cord-328289-3h3kmjlz 134 9 , , , cord-328289-3h3kmjlz 134 10 agitation agitation NN cord-328289-3h3kmjlz 134 11 , , , cord-328289-3h3kmjlz 134 12 somnolence somnolence NN cord-328289-3h3kmjlz 134 13 ) ) -RRB- cord-328289-3h3kmjlz 134 14 , , , cord-328289-3h3kmjlz 134 15 collectively collectively RB cord-328289-3h3kmjlz 134 16 defined define VBN cord-328289-3h3kmjlz 134 17 as as IN cord-328289-3h3kmjlz 134 18 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 134 19 , , , cord-328289-3h3kmjlz 134 20 have have VBP cord-328289-3h3kmjlz 134 21 been be VBN cord-328289-3h3kmjlz 134 22 consistently consistently RB cord-328289-3h3kmjlz 134 23 reported report VBN cord-328289-3h3kmjlz 134 24 in in IN cord-328289-3h3kmjlz 134 25 various various JJ cord-328289-3h3kmjlz 134 26 cohorts cohort NNS cord-328289-3h3kmjlz 134 27 with with IN cord-328289-3h3kmjlz 134 28 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 134 29 . . . cord-328289-3h3kmjlz 135 1 Altered alter VBN cord-328289-3h3kmjlz 135 2 mental mental JJ cord-328289-3h3kmjlz 135 3 status status NN cord-328289-3h3kmjlz 135 4 occurs occur VBZ cord-328289-3h3kmjlz 135 5 rarely rarely RB cord-328289-3h3kmjlz 135 6 ( ( -LRB- cord-328289-3h3kmjlz 135 7 < < NNP cord-328289-3h3kmjlz 135 8 5 5 CD cord-328289-3h3kmjlz 135 9 % % NN cord-328289-3h3kmjlz 135 10 ) ) -RRB- cord-328289-3h3kmjlz 135 11 even even RB cord-328289-3h3kmjlz 135 12 in in IN cord-328289-3h3kmjlz 135 13 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 135 14 patients patient NNS cord-328289-3h3kmjlz 135 15 requiring require VBG cord-328289-3h3kmjlz 135 16 hospitalization hospitalization NN cord-328289-3h3kmjlz 135 17 for for IN cord-328289-3h3kmjlz 135 18 respiratory respiratory JJ cord-328289-3h3kmjlz 135 19 illness illness NN cord-328289-3h3kmjlz 135 20 ( ( -LRB- cord-328289-3h3kmjlz 135 21 Mao Mao NNP cord-328289-3h3kmjlz 135 22 et et NNP cord-328289-3h3kmjlz 135 23 al al NNP cord-328289-3h3kmjlz 135 24 . . NNP cord-328289-3h3kmjlz 135 25 , , , cord-328289-3h3kmjlz 135 26 2020 2020 CD cord-328289-3h3kmjlz 135 27 ) ) -RRB- cord-328289-3h3kmjlz 135 28 , , , cord-328289-3h3kmjlz 135 29 but but CC cord-328289-3h3kmjlz 135 30 affects affect VBZ cord-328289-3h3kmjlz 135 31 the the DT cord-328289-3h3kmjlz 135 32 majority majority NN cord-328289-3h3kmjlz 135 33 of of IN cord-328289-3h3kmjlz 135 34 critically critically RB cord-328289-3h3kmjlz 135 35 ill ill JJ cord-328289-3h3kmjlz 135 36 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 135 37 patients patient NNS cord-328289-3h3kmjlz 135 38 with with IN cord-328289-3h3kmjlz 135 39 ARDS ARDS NNP cord-328289-3h3kmjlz 135 40 ( ( -LRB- cord-328289-3h3kmjlz 135 41 Helms Helms NNP cord-328289-3h3kmjlz 135 42 et et NNP cord-328289-3h3kmjlz 135 43 al al NNP cord-328289-3h3kmjlz 135 44 . . NNP cord-328289-3h3kmjlz 135 45 , , , cord-328289-3h3kmjlz 135 46 2020a 2020a CD cord-328289-3h3kmjlz 135 47 ) ) -RRB- cord-328289-3h3kmjlz 135 48 . . . cord-328289-3h3kmjlz 136 1 A a DT cord-328289-3h3kmjlz 136 2 key key JJ cord-328289-3h3kmjlz 136 3 question question NN cord-328289-3h3kmjlz 136 4 is be VBZ cord-328289-3h3kmjlz 136 5 whether whether IN cord-328289-3h3kmjlz 136 6 this this DT cord-328289-3h3kmjlz 136 7 alteration alteration NN cord-328289-3h3kmjlz 136 8 in in IN cord-328289-3h3kmjlz 136 9 mental mental JJ cord-328289-3h3kmjlz 136 10 status status NN cord-328289-3h3kmjlz 136 11 represents represent VBZ cord-328289-3h3kmjlz 136 12 an an DT cord-328289-3h3kmjlz 136 13 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 136 14 caused cause VBN cord-328289-3h3kmjlz 136 15 by by IN cord-328289-3h3kmjlz 136 16 systemic systemic JJ cord-328289-3h3kmjlz 136 17 illness illness NN cord-328289-3h3kmjlz 136 18 or or CC cord-328289-3h3kmjlz 136 19 an an DT cord-328289-3h3kmjlz 136 20 encephalitis encephalitis NN cord-328289-3h3kmjlz 136 21 directly directly RB cord-328289-3h3kmjlz 136 22 caused cause VBN cord-328289-3h3kmjlz 136 23 by by IN cord-328289-3h3kmjlz 136 24 the the DT cord-328289-3h3kmjlz 136 25 SARS SARS NNP cord-328289-3h3kmjlz 136 26 - - HYPH cord-328289-3h3kmjlz 136 27 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 136 28 virus virus NN cord-328289-3h3kmjlz 136 29 itself -PRON- PRP cord-328289-3h3kmjlz 136 30 . . . cord-328289-3h3kmjlz 137 1 Several several JJ cord-328289-3h3kmjlz 137 2 cases case NNS cord-328289-3h3kmjlz 137 3 have have VBP cord-328289-3h3kmjlz 137 4 been be VBN cord-328289-3h3kmjlz 137 5 reported report VBN cord-328289-3h3kmjlz 137 6 of of IN cord-328289-3h3kmjlz 137 7 COVID-19 covid-19 CD cord-328289-3h3kmjlz 137 8 patients patient NNS cord-328289-3h3kmjlz 137 9 ( ( -LRB- cord-328289-3h3kmjlz 137 10 Efe Efe NNP cord-328289-3h3kmjlz 137 11 et et NNP cord-328289-3h3kmjlz 137 12 al al NNP cord-328289-3h3kmjlz 137 13 . . NNP cord-328289-3h3kmjlz 137 14 , , , cord-328289-3h3kmjlz 137 15 2020 2020 CD cord-328289-3h3kmjlz 137 16 ; ; : cord-328289-3h3kmjlz 137 17 Farhadian Farhadian NNP cord-328289-3h3kmjlz 137 18 et et NNP cord-328289-3h3kmjlz 137 19 al al NNP cord-328289-3h3kmjlz 137 20 . . NNP cord-328289-3h3kmjlz 137 21 , , , cord-328289-3h3kmjlz 137 22 2020 2020 CD cord-328289-3h3kmjlz 137 23 ; ; : cord-328289-3h3kmjlz 137 24 Huang Huang NNP cord-328289-3h3kmjlz 137 25 et et NNP cord-328289-3h3kmjlz 137 26 al al NNP cord-328289-3h3kmjlz 137 27 . . . cord-328289-3h3kmjlz 138 1 , , , cord-328289-3h3kmjlz 138 2 2020b 2020b CD cord-328289-3h3kmjlz 138 3 ; ; : cord-328289-3h3kmjlz 138 4 Moriguchi Moriguchi NNP cord-328289-3h3kmjlz 138 5 et et NNP cord-328289-3h3kmjlz 138 6 al al NNP cord-328289-3h3kmjlz 138 7 . . . cord-328289-3h3kmjlz 139 1 , , , cord-328289-3h3kmjlz 139 2 2020 2020 CD cord-328289-3h3kmjlz 139 3 ; ; : cord-328289-3h3kmjlz 139 4 Pilotto Pilotto NNP cord-328289-3h3kmjlz 139 5 et et NNP cord-328289-3h3kmjlz 139 6 al al NNP cord-328289-3h3kmjlz 139 7 . . NNP cord-328289-3h3kmjlz 139 8 , , , cord-328289-3h3kmjlz 139 9 2020 2020 CD cord-328289-3h3kmjlz 139 10 ) ) -RRB- cord-328289-3h3kmjlz 139 11 who who WP cord-328289-3h3kmjlz 139 12 appear appear VBP cord-328289-3h3kmjlz 139 13 to to TO cord-328289-3h3kmjlz 139 14 meet meet VB cord-328289-3h3kmjlz 139 15 established established JJ cord-328289-3h3kmjlz 139 16 diagnostic diagnostic JJ cord-328289-3h3kmjlz 139 17 criteria criterion NNS cord-328289-3h3kmjlz 139 18 for for IN cord-328289-3h3kmjlz 139 19 infectious infectious JJ cord-328289-3h3kmjlz 139 20 encephalitis encephaliti NNS cord-328289-3h3kmjlz 139 21 , , , cord-328289-3h3kmjlz 139 22 which which WDT cord-328289-3h3kmjlz 139 23 include include VBP cord-328289-3h3kmjlz 139 24 altered alter VBN cord-328289-3h3kmjlz 139 25 mental mental JJ cord-328289-3h3kmjlz 139 26 status status NN cord-328289-3h3kmjlz 139 27 , , , cord-328289-3h3kmjlz 139 28 fever fever NN cord-328289-3h3kmjlz 139 29 , , , cord-328289-3h3kmjlz 139 30 seizures seizure NNS cord-328289-3h3kmjlz 139 31 , , , cord-328289-3h3kmjlz 139 32 white white JJ cord-328289-3h3kmjlz 139 33 blood blood NN cord-328289-3h3kmjlz 139 34 cells cell NNS cord-328289-3h3kmjlz 139 35 in in IN cord-328289-3h3kmjlz 139 36 the the DT cord-328289-3h3kmjlz 139 37 CSF CSF NNP cord-328289-3h3kmjlz 139 38 , , , cord-328289-3h3kmjlz 139 39 and and CC cord-328289-3h3kmjlz 139 40 focal focal JJ cord-328289-3h3kmjlz 139 41 brain brain NN cord-328289-3h3kmjlz 139 42 abnormalities abnormality NNS cord-328289-3h3kmjlz 139 43 on on IN cord-328289-3h3kmjlz 139 44 neuroimaging neuroimage VBG cord-328289-3h3kmjlz 139 45 ( ( -LRB- cord-328289-3h3kmjlz 139 46 Venkatesan Venkatesan NNP cord-328289-3h3kmjlz 139 47 et et FW cord-328289-3h3kmjlz 139 48 al al NNP cord-328289-3h3kmjlz 139 49 . . NNP cord-328289-3h3kmjlz 139 50 , , , cord-328289-3h3kmjlz 139 51 2013 2013 CD cord-328289-3h3kmjlz 139 52 ) ) -RRB- cord-328289-3h3kmjlz 139 53 . . . cord-328289-3h3kmjlz 140 1 In in IN cord-328289-3h3kmjlz 140 2 at at RB cord-328289-3h3kmjlz 140 3 least least RBS cord-328289-3h3kmjlz 140 4 two two CD cord-328289-3h3kmjlz 140 5 reported report VBN cord-328289-3h3kmjlz 140 6 cases case NNS cord-328289-3h3kmjlz 140 7 , , , cord-328289-3h3kmjlz 140 8 SARS SARS NNP cord-328289-3h3kmjlz 140 9 - - HYPH cord-328289-3h3kmjlz 140 10 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 140 11 was be VBD cord-328289-3h3kmjlz 140 12 detected detect VBN cord-328289-3h3kmjlz 140 13 in in IN cord-328289-3h3kmjlz 140 14 the the DT cord-328289-3h3kmjlz 140 15 CSF CSF NNP cord-328289-3h3kmjlz 140 16 ( ( -LRB- cord-328289-3h3kmjlz 140 17 Huang Huang NNP cord-328289-3h3kmjlz 140 18 et et NNP cord-328289-3h3kmjlz 140 19 al al NNP cord-328289-3h3kmjlz 140 20 . . NNP cord-328289-3h3kmjlz 140 21 , , , cord-328289-3h3kmjlz 140 22 2020b 2020b CD cord-328289-3h3kmjlz 140 23 ; ; : cord-328289-3h3kmjlz 140 24 Moriguchi Moriguchi NNP cord-328289-3h3kmjlz 140 25 et et NNP cord-328289-3h3kmjlz 140 26 al al NNP cord-328289-3h3kmjlz 140 27 . . NNP cord-328289-3h3kmjlz 140 28 , , , cord-328289-3h3kmjlz 140 29 2020 2020 CD cord-328289-3h3kmjlz 140 30 ) ) -RRB- cord-328289-3h3kmjlz 141 1 although although IN cord-328289-3h3kmjlz 141 2 , , , cord-328289-3h3kmjlz 141 3 as as IN cord-328289-3h3kmjlz 141 4 discussed discuss VBN cord-328289-3h3kmjlz 141 5 in in IN cord-328289-3h3kmjlz 141 6 the the DT cord-328289-3h3kmjlz 141 7 previous previous JJ cord-328289-3h3kmjlz 141 8 section section NN cord-328289-3h3kmjlz 141 9 ( ( -LRB- cord-328289-3h3kmjlz 141 10 Nervous nervous JJ cord-328289-3h3kmjlz 141 11 system system NN cord-328289-3h3kmjlz 141 12 invasion invasion NN cord-328289-3h3kmjlz 141 13 ) ) -RRB- cord-328289-3h3kmjlz 141 14 , , , cord-328289-3h3kmjlz 141 15 only only RB cord-328289-3h3kmjlz 141 16 modest modest JJ cord-328289-3h3kmjlz 141 17 amounts amount NNS cord-328289-3h3kmjlz 141 18 of of IN cord-328289-3h3kmjlz 141 19 viral viral JJ cord-328289-3h3kmjlz 141 20 RNA RNA NNP cord-328289-3h3kmjlz 141 21 were be VBD cord-328289-3h3kmjlz 141 22 detected detect VBN cord-328289-3h3kmjlz 141 23 . . . cord-328289-3h3kmjlz 142 1 In in IN cord-328289-3h3kmjlz 142 2 at at RB cord-328289-3h3kmjlz 142 3 least least RBS cord-328289-3h3kmjlz 142 4 one one CD cord-328289-3h3kmjlz 142 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 142 6 case case NN cord-328289-3h3kmjlz 142 7 , , , cord-328289-3h3kmjlz 142 8 the the DT cord-328289-3h3kmjlz 142 9 diagnosis diagnosis NN cord-328289-3h3kmjlz 142 10 of of IN cord-328289-3h3kmjlz 142 11 temporal temporal JJ cord-328289-3h3kmjlz 142 12 lobe lobe NN cord-328289-3h3kmjlz 142 13 encephalitis encephalitis NNP cord-328289-3h3kmjlz 142 14 was be VBD cord-328289-3h3kmjlz 142 15 confirmed confirm VBN cord-328289-3h3kmjlz 142 16 by by IN cord-328289-3h3kmjlz 142 17 biopsy biopsy NN cord-328289-3h3kmjlz 142 18 which which WDT cord-328289-3h3kmjlz 142 19 showed show VBD cord-328289-3h3kmjlz 142 20 perivascular perivascular JJ cord-328289-3h3kmjlz 142 21 lymphocytic lymphocytic JJ cord-328289-3h3kmjlz 142 22 infiltrates infiltrate VBZ cord-328289-3h3kmjlz 142 23 and and CC cord-328289-3h3kmjlz 142 24 hypoxic hypoxic JJ cord-328289-3h3kmjlz 142 25 neuronal neuronal JJ cord-328289-3h3kmjlz 142 26 damage damage NN cord-328289-3h3kmjlz 143 1 ( ( -LRB- cord-328289-3h3kmjlz 143 2 Efe Efe NNP cord-328289-3h3kmjlz 143 3 et et NNP cord-328289-3h3kmjlz 143 4 al al NNP cord-328289-3h3kmjlz 143 5 . . NNP cord-328289-3h3kmjlz 143 6 , , , cord-328289-3h3kmjlz 143 7 2020 2020 CD cord-328289-3h3kmjlz 143 8 ) ) -RRB- cord-328289-3h3kmjlz 143 9 , , , cord-328289-3h3kmjlz 143 10 but but CC cord-328289-3h3kmjlz 143 11 the the DT cord-328289-3h3kmjlz 143 12 presence presence NN cord-328289-3h3kmjlz 143 13 of of IN cord-328289-3h3kmjlz 143 14 SARS SARS NNP cord-328289-3h3kmjlz 143 15 - - HYPH cord-328289-3h3kmjlz 143 16 CoV2 CoV2 NNS cord-328289-3h3kmjlz 143 17 or or CC cord-328289-3h3kmjlz 143 18 other other JJ cord-328289-3h3kmjlz 143 19 viruses virus NNS cord-328289-3h3kmjlz 143 20 in in IN cord-328289-3h3kmjlz 143 21 brain brain NN cord-328289-3h3kmjlz 143 22 or or CC cord-328289-3h3kmjlz 143 23 CSF CSF NNP cord-328289-3h3kmjlz 143 24 was be VBD cord-328289-3h3kmjlz 143 25 not not RB cord-328289-3h3kmjlz 143 26 documented document VBN cord-328289-3h3kmjlz 143 27 . . . cord-328289-3h3kmjlz 144 1 Indeed indeed RB cord-328289-3h3kmjlz 144 2 , , , cord-328289-3h3kmjlz 144 3 most most JJS cord-328289-3h3kmjlz 144 4 samples sample NNS cord-328289-3h3kmjlz 144 5 of of IN cord-328289-3h3kmjlz 144 6 CSF CSF NNP cord-328289-3h3kmjlz 144 7 in in IN cord-328289-3h3kmjlz 144 8 patients patient NNS cord-328289-3h3kmjlz 144 9 with with IN cord-328289-3h3kmjlz 144 10 neurological neurological JJ cord-328289-3h3kmjlz 144 11 abnormalities abnormality NNS cord-328289-3h3kmjlz 144 12 in in IN cord-328289-3h3kmjlz 144 13 the the DT cord-328289-3h3kmjlz 144 14 setting setting NN cord-328289-3h3kmjlz 144 15 of of IN cord-328289-3h3kmjlz 144 16 COVID-19 COVID-19 , cord-328289-3h3kmjlz 144 17 have have VBP cord-328289-3h3kmjlz 144 18 not not RB cord-328289-3h3kmjlz 144 19 revealed reveal VBN cord-328289-3h3kmjlz 144 20 evidence evidence NN cord-328289-3h3kmjlz 144 21 of of IN cord-328289-3h3kmjlz 144 22 SARS SARS NNP cord-328289-3h3kmjlz 144 23 - - HYPH cord-328289-3h3kmjlz 144 24 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 144 25 ( ( -LRB- cord-328289-3h3kmjlz 144 26 Kandemirli Kandemirli NNP cord-328289-3h3kmjlz 144 27 et et FW cord-328289-3h3kmjlz 144 28 al al NNP cord-328289-3h3kmjlz 144 29 . . NNP cord-328289-3h3kmjlz 144 30 , , , cord-328289-3h3kmjlz 144 31 2020 2020 CD cord-328289-3h3kmjlz 144 32 ) ) -RRB- cord-328289-3h3kmjlz 144 33 and and CC cord-328289-3h3kmjlz 144 34 most most JJS cord-328289-3h3kmjlz 144 35 samples sample NNS cord-328289-3h3kmjlz 144 36 of of IN cord-328289-3h3kmjlz 144 37 brain brain NN cord-328289-3h3kmjlz 144 38 tissue tissue NN cord-328289-3h3kmjlz 144 39 from from IN cord-328289-3h3kmjlz 144 40 autopsies autopsy NNS cord-328289-3h3kmjlz 144 41 of of IN cord-328289-3h3kmjlz 144 42 COVID-19 covid-19 CD cord-328289-3h3kmjlz 144 43 patients patient NNS cord-328289-3h3kmjlz 144 44 have have VBP cord-328289-3h3kmjlz 144 45 not not RB cord-328289-3h3kmjlz 144 46 revealed reveal VBN cord-328289-3h3kmjlz 144 47 evidence evidence NN cord-328289-3h3kmjlz 144 48 of of IN cord-328289-3h3kmjlz 144 49 encephalitis encephalitis JJ cord-328289-3h3kmjlz 144 50 ( ( -LRB- cord-328289-3h3kmjlz 144 51 see see VB cord-328289-3h3kmjlz 144 52 Nervous nervous JJ cord-328289-3h3kmjlz 144 53 system system NN cord-328289-3h3kmjlz 144 54 invasion invasion NN cord-328289-3h3kmjlz 144 55 ) ) -RRB- cord-328289-3h3kmjlz 144 56 . . . cord-328289-3h3kmjlz 145 1 Besides besides IN cord-328289-3h3kmjlz 145 2 encephalitis encephalitis NN cord-328289-3h3kmjlz 145 3 , , , cord-328289-3h3kmjlz 145 4 most most JJS cord-328289-3h3kmjlz 145 5 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 145 6 patients patient NNS cord-328289-3h3kmjlz 145 7 have have VBP cord-328289-3h3kmjlz 145 8 other other JJ cord-328289-3h3kmjlz 145 9 reasons reason NNS cord-328289-3h3kmjlz 145 10 for for IN cord-328289-3h3kmjlz 145 11 their -PRON- PRP$ cord-328289-3h3kmjlz 145 12 altered altered JJ cord-328289-3h3kmjlz 145 13 mental mental JJ cord-328289-3h3kmjlz 145 14 status status NN cord-328289-3h3kmjlz 145 15 . . . cord-328289-3h3kmjlz 146 1 Delirium delirium NN cord-328289-3h3kmjlz 146 2 , , , cord-328289-3h3kmjlz 146 3 confusional confusional JJ cord-328289-3h3kmjlz 146 4 states state NNS cord-328289-3h3kmjlz 146 5 , , , cord-328289-3h3kmjlz 146 6 and and CC cord-328289-3h3kmjlz 146 7 coma coma NN cord-328289-3h3kmjlz 146 8 appear appear VBP cord-328289-3h3kmjlz 146 9 most most RBS cord-328289-3h3kmjlz 146 10 common common JJ cord-328289-3h3kmjlz 146 11 in in IN cord-328289-3h3kmjlz 146 12 COVID-19-related covid-19-related JJ cord-328289-3h3kmjlz 146 13 critical critical JJ cord-328289-3h3kmjlz 146 14 illness illness NN cord-328289-3h3kmjlz 146 15 ( ( -LRB- cord-328289-3h3kmjlz 146 16 Helms Helms NNP cord-328289-3h3kmjlz 146 17 et et NNP cord-328289-3h3kmjlz 146 18 al al NNP cord-328289-3h3kmjlz 146 19 . . NNP cord-328289-3h3kmjlz 146 20 , , , cord-328289-3h3kmjlz 146 21 2020a 2020a CD cord-328289-3h3kmjlz 146 22 ; ; : cord-328289-3h3kmjlz 147 1 Mao Mao NNP cord-328289-3h3kmjlz 147 2 et et NNP cord-328289-3h3kmjlz 147 3 al al NNP cord-328289-3h3kmjlz 147 4 . . . cord-328289-3h3kmjlz 148 1 , , , cord-328289-3h3kmjlz 148 2 2020 2020 CD cord-328289-3h3kmjlz 148 3 ; ; : cord-328289-3h3kmjlz 148 4 Rogers Rogers NNP cord-328289-3h3kmjlz 148 5 et et NNP cord-328289-3h3kmjlz 148 6 al al NNP cord-328289-3h3kmjlz 148 7 . . NNP cord-328289-3h3kmjlz 148 8 , , , cord-328289-3h3kmjlz 148 9 2020 2020 CD cord-328289-3h3kmjlz 148 10 ) ) -RRB- cord-328289-3h3kmjlz 148 11 , , , cord-328289-3h3kmjlz 148 12 which which WDT cord-328289-3h3kmjlz 148 13 is be VBZ cord-328289-3h3kmjlz 148 14 often often RB cord-328289-3h3kmjlz 148 15 marked mark VBN cord-328289-3h3kmjlz 148 16 by by IN cord-328289-3h3kmjlz 148 17 hypoxia hypoxia NN cord-328289-3h3kmjlz 148 18 , , , cord-328289-3h3kmjlz 148 19 hypotension hypotension NN cord-328289-3h3kmjlz 148 20 , , , cord-328289-3h3kmjlz 148 21 renal renal JJ cord-328289-3h3kmjlz 148 22 failure failure NN cord-328289-3h3kmjlz 148 23 , , , cord-328289-3h3kmjlz 149 1 the the DT cord-328289-3h3kmjlz 149 2 need need NN cord-328289-3h3kmjlz 149 3 for for IN cord-328289-3h3kmjlz 149 4 heavy heavy JJ cord-328289-3h3kmjlz 149 5 doses dose NNS cord-328289-3h3kmjlz 149 6 of of IN cord-328289-3h3kmjlz 149 7 sedatives sedative NNS cord-328289-3h3kmjlz 149 8 , , , cord-328289-3h3kmjlz 149 9 and and CC cord-328289-3h3kmjlz 149 10 prolonged prolong VBN cord-328289-3h3kmjlz 149 11 immobility immobility NN cord-328289-3h3kmjlz 149 12 and and CC cord-328289-3h3kmjlz 149 13 isolation isolation NN cord-328289-3h3kmjlz 149 14 ( ( -LRB- cord-328289-3h3kmjlz 149 15 Cummings Cummings NNP cord-328289-3h3kmjlz 149 16 et et FW cord-328289-3h3kmjlz 149 17 al al NNP cord-328289-3h3kmjlz 149 18 . . . cord-328289-3h3kmjlz 150 1 , , , cord-328289-3h3kmjlz 150 2 2020)-all 2020)-all CD cord-328289-3h3kmjlz 150 3 factors factor NNS cord-328289-3h3kmjlz 150 4 well well RB cord-328289-3h3kmjlz 150 5 known know VBN cord-328289-3h3kmjlz 150 6 to to TO cord-328289-3h3kmjlz 150 7 cause cause VB cord-328289-3h3kmjlz 150 8 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 150 9 ( ( -LRB- cord-328289-3h3kmjlz 150 10 Maas Maas NNP cord-328289-3h3kmjlz 150 11 , , , cord-328289-3h3kmjlz 150 12 2020 2020 CD cord-328289-3h3kmjlz 150 13 ) ) -RRB- cord-328289-3h3kmjlz 150 14 . . . cord-328289-3h3kmjlz 151 1 The the DT cord-328289-3h3kmjlz 151 2 rarity rarity NN cord-328289-3h3kmjlz 151 3 of of IN cord-328289-3h3kmjlz 151 4 cases case NNS cord-328289-3h3kmjlz 151 5 clinically clinically RB cord-328289-3h3kmjlz 151 6 consistent consistent JJ cord-328289-3h3kmjlz 151 7 with with IN cord-328289-3h3kmjlz 151 8 encephalitis encephalitis NN cord-328289-3h3kmjlz 151 9 , , , cord-328289-3h3kmjlz 151 10 the the DT cord-328289-3h3kmjlz 151 11 paucity paucity NN cord-328289-3h3kmjlz 151 12 of of IN cord-328289-3h3kmjlz 151 13 histopathological histopathological JJ cord-328289-3h3kmjlz 151 14 evidence evidence NN cord-328289-3h3kmjlz 151 15 of of IN cord-328289-3h3kmjlz 151 16 encephalitis encephalitis NN cord-328289-3h3kmjlz 151 17 , , , cord-328289-3h3kmjlz 151 18 and and CC cord-328289-3h3kmjlz 151 19 the the DT cord-328289-3h3kmjlz 151 20 many many JJ cord-328289-3h3kmjlz 151 21 alternative alternative JJ cord-328289-3h3kmjlz 151 22 explanations explanation NNS cord-328289-3h3kmjlz 151 23 for for IN cord-328289-3h3kmjlz 151 24 the the DT cord-328289-3h3kmjlz 151 25 altered altered JJ cord-328289-3h3kmjlz 151 26 mental mental JJ cord-328289-3h3kmjlz 151 27 status status NN cord-328289-3h3kmjlz 151 28 suggest suggest VBP cord-328289-3h3kmjlz 151 29 that that IN cord-328289-3h3kmjlz 151 30 SARS SARS NNP cord-328289-3h3kmjlz 151 31 - - HYPH cord-328289-3h3kmjlz 151 32 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 151 33 brain brain NN cord-328289-3h3kmjlz 151 34 invasion invasion NN cord-328289-3h3kmjlz 151 35 is be VBZ cord-328289-3h3kmjlz 151 36 a a DT cord-328289-3h3kmjlz 151 37 possible possible JJ cord-328289-3h3kmjlz 151 38 but but CC cord-328289-3h3kmjlz 151 39 rare rare JJ cord-328289-3h3kmjlz 151 40 cause cause NN cord-328289-3h3kmjlz 151 41 of of IN cord-328289-3h3kmjlz 151 42 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 151 43 . . . cord-328289-3h3kmjlz 152 1 Ischemic ischemic JJ cord-328289-3h3kmjlz 152 2 stroke stroke NN cord-328289-3h3kmjlz 152 3 : : : cord-328289-3h3kmjlz 152 4 Stroke stroke NN cord-328289-3h3kmjlz 152 5 is be VBZ cord-328289-3h3kmjlz 152 6 not not RB cord-328289-3h3kmjlz 152 7 uncommon uncommon JJ cord-328289-3h3kmjlz 152 8 among among IN cord-328289-3h3kmjlz 152 9 patients patient NNS cord-328289-3h3kmjlz 152 10 hospitalized hospitalize VBN cord-328289-3h3kmjlz 152 11 with with IN cord-328289-3h3kmjlz 152 12 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 152 13 , , , cord-328289-3h3kmjlz 152 14 with with IN cord-328289-3h3kmjlz 152 15 reported report VBN cord-328289-3h3kmjlz 152 16 rates rate NNS cord-328289-3h3kmjlz 152 17 ranging range VBG cord-328289-3h3kmjlz 152 18 from from IN cord-328289-3h3kmjlz 152 19 1 1 CD cord-328289-3h3kmjlz 152 20 - - SYM cord-328289-3h3kmjlz 152 21 3 3 CD cord-328289-3h3kmjlz 152 22 % % NN cord-328289-3h3kmjlz 152 23 in in IN cord-328289-3h3kmjlz 152 24 hospitalized hospitalize VBN cord-328289-3h3kmjlz 152 25 patients patient NNS cord-328289-3h3kmjlz 152 26 and and CC cord-328289-3h3kmjlz 152 27 up up IN cord-328289-3h3kmjlz 152 28 to to TO cord-328289-3h3kmjlz 152 29 6 6 CD cord-328289-3h3kmjlz 152 30 % % NN cord-328289-3h3kmjlz 152 31 of of IN cord-328289-3h3kmjlz 152 32 critically critically RB cord-328289-3h3kmjlz 152 33 ill ill JJ cord-328289-3h3kmjlz 152 34 patients patient NNS cord-328289-3h3kmjlz 152 35 ( ( -LRB- cord-328289-3h3kmjlz 152 36 Mao Mao NNP cord-328289-3h3kmjlz 152 37 et et NNP cord-328289-3h3kmjlz 152 38 al al NNP cord-328289-3h3kmjlz 152 39 . . NNP cord-328289-3h3kmjlz 152 40 , , , cord-328289-3h3kmjlz 152 41 2020 2020 CD cord-328289-3h3kmjlz 152 42 ; ; : cord-328289-3h3kmjlz 152 43 Merkler Merkler NNP cord-328289-3h3kmjlz 152 44 et et NNP cord-328289-3h3kmjlz 152 45 al al NNP cord-328289-3h3kmjlz 152 46 . . NNP cord-328289-3h3kmjlz 152 47 , , , cord-328289-3h3kmjlz 152 48 2020 2020 CD cord-328289-3h3kmjlz 152 49 ; ; . cord-328289-3h3kmjlz 153 1 Yaghi Yaghi NNP cord-328289-3h3kmjlz 153 2 et et NNP cord-328289-3h3kmjlz 153 3 al al NNP cord-328289-3h3kmjlz 153 4 . . NNP cord-328289-3h3kmjlz 153 5 , , , cord-328289-3h3kmjlz 153 6 2020 2020 CD cord-328289-3h3kmjlz 153 7 ) ) -RRB- cord-328289-3h3kmjlz 153 8 , , , cord-328289-3h3kmjlz 153 9 7-fold 7-fold CD cord-328289-3h3kmjlz 153 10 higher high JJR cord-328289-3h3kmjlz 153 11 than than IN cord-328289-3h3kmjlz 153 12 in in IN cord-328289-3h3kmjlz 153 13 patients patient NNS cord-328289-3h3kmjlz 153 14 hospitalized hospitalize VBN cord-328289-3h3kmjlz 153 15 with with IN cord-328289-3h3kmjlz 153 16 influenza influenza NN cord-328289-3h3kmjlz 153 17 even even RB cord-328289-3h3kmjlz 153 18 after after IN cord-328289-3h3kmjlz 153 19 adjustment adjustment NN cord-328289-3h3kmjlz 153 20 for for IN cord-328289-3h3kmjlz 153 21 illness illness NN cord-328289-3h3kmjlz 153 22 severity severity NN cord-328289-3h3kmjlz 153 23 . . . cord-328289-3h3kmjlz 154 1 Early early JJ cord-328289-3h3kmjlz 154 2 case case NN cord-328289-3h3kmjlz 154 3 reports report NNS cord-328289-3h3kmjlz 154 4 described describe VBD cord-328289-3h3kmjlz 154 5 unusual unusual JJ cord-328289-3h3kmjlz 154 6 embolic embolic JJ cord-328289-3h3kmjlz 154 7 strokes stroke NNS cord-328289-3h3kmjlz 154 8 in in IN cord-328289-3h3kmjlz 154 9 otherwise otherwise RB cord-328289-3h3kmjlz 154 10 young young JJ cord-328289-3h3kmjlz 154 11 healthy healthy JJ cord-328289-3h3kmjlz 154 12 individuals individual NNS cord-328289-3h3kmjlz 154 13 with with IN cord-328289-3h3kmjlz 154 14 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 154 15 ( ( -LRB- cord-328289-3h3kmjlz 154 16 Oxley Oxley NNP cord-328289-3h3kmjlz 154 17 et et NNP cord-328289-3h3kmjlz 154 18 al al NNP cord-328289-3h3kmjlz 154 19 . . NNP cord-328289-3h3kmjlz 154 20 , , , cord-328289-3h3kmjlz 154 21 2020 2020 CD cord-328289-3h3kmjlz 154 22 ) ) -RRB- cord-328289-3h3kmjlz 154 23 , , , cord-328289-3h3kmjlz 154 24 but but CC cord-328289-3h3kmjlz 154 25 in in IN cord-328289-3h3kmjlz 154 26 subsequent subsequent JJ cord-328289-3h3kmjlz 154 27 case case NN cord-328289-3h3kmjlz 154 28 series series NN cord-328289-3h3kmjlz 154 29 patients patient NNS cord-328289-3h3kmjlz 154 30 were be VBD cord-328289-3h3kmjlz 154 31 generally generally RB cord-328289-3h3kmjlz 154 32 older old JJR cord-328289-3h3kmjlz 154 33 and and CC cord-328289-3h3kmjlz 154 34 had have VBD cord-328289-3h3kmjlz 154 35 numerous numerous JJ cord-328289-3h3kmjlz 154 36 vascular vascular JJ cord-328289-3h3kmjlz 154 37 comorbidities comorbiditie NNS cord-328289-3h3kmjlz 154 38 ( ( -LRB- cord-328289-3h3kmjlz 154 39 Lodigiani Lodigiani NNP cord-328289-3h3kmjlz 154 40 et et NNP cord-328289-3h3kmjlz 154 41 al al NNP cord-328289-3h3kmjlz 154 42 . . NNP cord-328289-3h3kmjlz 154 43 , , , cord-328289-3h3kmjlz 154 44 2020 2020 CD cord-328289-3h3kmjlz 154 45 ) ) -RRB- cord-328289-3h3kmjlz 154 46 . . . cord-328289-3h3kmjlz 155 1 Therefore therefore RB cord-328289-3h3kmjlz 155 2 , , , cord-328289-3h3kmjlz 155 3 it -PRON- PRP cord-328289-3h3kmjlz 155 4 remains remain VBZ cord-328289-3h3kmjlz 155 5 unclear unclear JJ cord-328289-3h3kmjlz 155 6 whether whether IN cord-328289-3h3kmjlz 155 7 these these DT cord-328289-3h3kmjlz 155 8 strokes stroke NNS cord-328289-3h3kmjlz 155 9 were be VBD cord-328289-3h3kmjlz 155 10 caused cause VBN cord-328289-3h3kmjlz 155 11 by by IN cord-328289-3h3kmjlz 155 12 SARS SARS NNP cord-328289-3h3kmjlz 155 13 - - HYPH cord-328289-3h3kmjlz 155 14 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 155 15 or or CC cord-328289-3h3kmjlz 155 16 represented represent VBD cord-328289-3h3kmjlz 155 17 the the DT cord-328289-3h3kmjlz 155 18 background background NN cord-328289-3h3kmjlz 155 19 incidence incidence NN cord-328289-3h3kmjlz 155 20 of of IN cord-328289-3h3kmjlz 155 21 stroke stroke NN cord-328289-3h3kmjlz 155 22 in in IN cord-328289-3h3kmjlz 155 23 this this DT cord-328289-3h3kmjlz 155 24 high high JJ cord-328289-3h3kmjlz 155 25 - - HYPH cord-328289-3h3kmjlz 155 26 risk risk NN cord-328289-3h3kmjlz 155 27 populations population NNS cord-328289-3h3kmjlz 155 28 that that WDT cord-328289-3h3kmjlz 155 29 also also RB cord-328289-3h3kmjlz 155 30 happened happen VBD cord-328289-3h3kmjlz 155 31 to to TO cord-328289-3h3kmjlz 155 32 be be VB cord-328289-3h3kmjlz 155 33 infected infect VBN cord-328289-3h3kmjlz 155 34 at at IN cord-328289-3h3kmjlz 155 35 the the DT cord-328289-3h3kmjlz 155 36 time time NN cord-328289-3h3kmjlz 155 37 . . . cord-328289-3h3kmjlz 156 1 It -PRON- PRP cord-328289-3h3kmjlz 156 2 is be VBZ cord-328289-3h3kmjlz 156 3 plausible plausible JJ cord-328289-3h3kmjlz 156 4 that that IN cord-328289-3h3kmjlz 156 5 SARS SARS NNP cord-328289-3h3kmjlz 156 6 - - HYPH cord-328289-3h3kmjlz 156 7 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 156 8 infection infection NN cord-328289-3h3kmjlz 156 9 does do VBZ cord-328289-3h3kmjlz 156 10 play play VB cord-328289-3h3kmjlz 156 11 some some DT cord-328289-3h3kmjlz 156 12 role role NN cord-328289-3h3kmjlz 156 13 in in IN cord-328289-3h3kmjlz 156 14 causing cause VBG cord-328289-3h3kmjlz 156 15 stroke stroke NN cord-328289-3h3kmjlz 156 16 , , , cord-328289-3h3kmjlz 156 17 given give VBN cord-328289-3h3kmjlz 156 18 that that IN cord-328289-3h3kmjlz 156 19 infections infection NNS cord-328289-3h3kmjlz 156 20 in in IN cord-328289-3h3kmjlz 156 21 general general JJ cord-328289-3h3kmjlz 156 22 increases increase NNS cord-328289-3h3kmjlz 156 23 stroke stroke NN cord-328289-3h3kmjlz 156 24 risk risk NN cord-328289-3h3kmjlz 156 25 . . . cord-328289-3h3kmjlz 157 1 The the DT cord-328289-3h3kmjlz 157 2 COVID-19-related covid-19-related JJ cord-328289-3h3kmjlz 157 3 hypercoagulability hypercoagulability NN cord-328289-3h3kmjlz 157 4 would would MD cord-328289-3h3kmjlz 157 5 be be VB cord-328289-3h3kmjlz 157 6 expected expect VBN cord-328289-3h3kmjlz 157 7 to to TO cord-328289-3h3kmjlz 157 8 increase increase VB cord-328289-3h3kmjlz 157 9 susceptibility susceptibility NN cord-328289-3h3kmjlz 157 10 to to IN cord-328289-3h3kmjlz 157 11 cerebrovascular cerebrovascular JJ cord-328289-3h3kmjlz 157 12 events event NNS cord-328289-3h3kmjlz 157 13 , , , cord-328289-3h3kmjlz 157 14 as as IN cord-328289-3h3kmjlz 157 15 reported report VBN cord-328289-3h3kmjlz 157 16 in in IN cord-328289-3h3kmjlz 157 17 an an DT cord-328289-3h3kmjlz 157 18 autopsy autopsy JJ cord-328289-3h3kmjlz 157 19 series series NN cord-328289-3h3kmjlz 157 20 in in IN cord-328289-3h3kmjlz 157 21 which which WDT cord-328289-3h3kmjlz 157 22 widespread widespread JJ cord-328289-3h3kmjlz 157 23 microthrombi microthrombi NN cord-328289-3h3kmjlz 157 24 and and CC cord-328289-3h3kmjlz 157 25 patches patch NNS cord-328289-3h3kmjlz 157 26 of of IN cord-328289-3h3kmjlz 157 27 infarction infarction NN cord-328289-3h3kmjlz 157 28 were be VBD cord-328289-3h3kmjlz 157 29 observed observe VBN cord-328289-3h3kmjlz 157 30 some some DT cord-328289-3h3kmjlz 157 31 brains brain NNS cord-328289-3h3kmjlz 157 32 ( ( -LRB- cord-328289-3h3kmjlz 157 33 Bryce Bryce NNP cord-328289-3h3kmjlz 157 34 et et NNP cord-328289-3h3kmjlz 157 35 al al NNP cord-328289-3h3kmjlz 157 36 . . NNP cord-328289-3h3kmjlz 157 37 , , , cord-328289-3h3kmjlz 157 38 2020 2020 CD cord-328289-3h3kmjlz 157 39 ) ) -RRB- cord-328289-3h3kmjlz 157 40 . . . cord-328289-3h3kmjlz 158 1 Patients patient NNS cord-328289-3h3kmjlz 158 2 with with IN cord-328289-3h3kmjlz 158 3 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 158 4 may may MD cord-328289-3h3kmjlz 158 5 be be VB cord-328289-3h3kmjlz 158 6 at at IN cord-328289-3h3kmjlz 158 7 risk risk NN cord-328289-3h3kmjlz 158 8 of of IN cord-328289-3h3kmjlz 158 9 cardioembolic cardioembolic NNP cord-328289-3h3kmjlz 158 10 stroke stroke NN cord-328289-3h3kmjlz 158 11 . . . cord-328289-3h3kmjlz 159 1 Acute acute JJ cord-328289-3h3kmjlz 159 2 cardiac cardiac JJ cord-328289-3h3kmjlz 159 3 injury injury NN cord-328289-3h3kmjlz 159 4 and and CC cord-328289-3h3kmjlz 159 5 clinically clinically RB cord-328289-3h3kmjlz 159 6 significant significant JJ cord-328289-3h3kmjlz 159 7 arrhythmias arrhythmia NNS cord-328289-3h3kmjlz 159 8 have have VBP cord-328289-3h3kmjlz 159 9 been be VBN cord-328289-3h3kmjlz 159 10 reported report VBN cord-328289-3h3kmjlz 159 11 in in IN cord-328289-3h3kmjlz 159 12 approximately approximately RB cord-328289-3h3kmjlz 159 13 10 10 CD cord-328289-3h3kmjlz 159 14 % % NN cord-328289-3h3kmjlz 159 15 of of IN cord-328289-3h3kmjlz 159 16 hospitalized hospitalize VBN cord-328289-3h3kmjlz 159 17 COVID-19 covid-19 CD cord-328289-3h3kmjlz 159 18 patients patient NNS cord-328289-3h3kmjlz 159 19 and and CC cord-328289-3h3kmjlz 159 20 20 20 CD cord-328289-3h3kmjlz 159 21 - - SYM cord-328289-3h3kmjlz 159 22 40 40 CD cord-328289-3h3kmjlz 159 23 % % NN cord-328289-3h3kmjlz 159 24 of of IN cord-328289-3h3kmjlz 159 25 those those DT cord-328289-3h3kmjlz 159 26 requiring require VBG cord-328289-3h3kmjlz 159 27 intensive intensive JJ cord-328289-3h3kmjlz 159 28 care care NN cord-328289-3h3kmjlz 160 1 Huang Huang NNP cord-328289-3h3kmjlz 160 2 et et NNP cord-328289-3h3kmjlz 160 3 al al NNP cord-328289-3h3kmjlz 160 4 . . . cord-328289-3h3kmjlz 161 1 , , , cord-328289-3h3kmjlz 161 2 2020a 2020a CD cord-328289-3h3kmjlz 161 3 ; ; : cord-328289-3h3kmjlz 161 4 Wang Wang NNP cord-328289-3h3kmjlz 161 5 et et NNP cord-328289-3h3kmjlz 161 6 al al NNP cord-328289-3h3kmjlz 161 7 . . NNP cord-328289-3h3kmjlz 161 8 , , , cord-328289-3h3kmjlz 161 9 2020a 2020a CD cord-328289-3h3kmjlz 161 10 ) ) -RRB- cord-328289-3h3kmjlz 161 11 . . . cord-328289-3h3kmjlz 162 1 SARS SARS NNP cord-328289-3h3kmjlz 162 2 - - HYPH cord-328289-3h3kmjlz 162 3 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 162 4 infection infection NN cord-328289-3h3kmjlz 162 5 may may MD cord-328289-3h3kmjlz 162 6 rarely rarely RB cord-328289-3h3kmjlz 162 7 cause cause VB cord-328289-3h3kmjlz 162 8 myocarditis myocarditis NN cord-328289-3h3kmjlz 162 9 and and CC cord-328289-3h3kmjlz 162 10 heart heart NN cord-328289-3h3kmjlz 162 11 failure failure NN cord-328289-3h3kmjlz 162 12 even even RB cord-328289-3h3kmjlz 162 13 in in IN cord-328289-3h3kmjlz 162 14 the the DT cord-328289-3h3kmjlz 162 15 absence absence NN cord-328289-3h3kmjlz 162 16 of of IN cord-328289-3h3kmjlz 162 17 significant significant JJ cord-328289-3h3kmjlz 162 18 pulmonary pulmonary JJ cord-328289-3h3kmjlz 162 19 involvement involvement NN cord-328289-3h3kmjlz 163 1 ( ( -LRB- cord-328289-3h3kmjlz 163 2 Inciardi Inciardi NNP cord-328289-3h3kmjlz 163 3 et et NNP cord-328289-3h3kmjlz 163 4 al al NNP cord-328289-3h3kmjlz 163 5 . . NNP cord-328289-3h3kmjlz 163 6 , , , cord-328289-3h3kmjlz 163 7 2020 2020 CD cord-328289-3h3kmjlz 163 8 ) ) -RRB- cord-328289-3h3kmjlz 163 9 . . . cord-328289-3h3kmjlz 164 1 Myocardial myocardial JJ cord-328289-3h3kmjlz 164 2 injury injury NN cord-328289-3h3kmjlz 164 3 and and CC cord-328289-3h3kmjlz 164 4 arrhythmias arrhythmia NNS cord-328289-3h3kmjlz 164 5 , , , cord-328289-3h3kmjlz 164 6 such such JJ cord-328289-3h3kmjlz 164 7 as as IN cord-328289-3h3kmjlz 164 8 atrial atrial JJ cord-328289-3h3kmjlz 164 9 fibrillation fibrillation NN cord-328289-3h3kmjlz 164 10 , , , cord-328289-3h3kmjlz 164 11 in in IN cord-328289-3h3kmjlz 164 12 the the DT cord-328289-3h3kmjlz 164 13 setting setting NN cord-328289-3h3kmjlz 164 14 of of IN cord-328289-3h3kmjlz 164 15 severe severe JJ cord-328289-3h3kmjlz 164 16 infection infection NN cord-328289-3h3kmjlz 164 17 may may MD cord-328289-3h3kmjlz 164 18 result result VB cord-328289-3h3kmjlz 164 19 in in IN cord-328289-3h3kmjlz 164 20 cardiac cardiac JJ cord-328289-3h3kmjlz 164 21 embolism embolism NN cord-328289-3h3kmjlz 164 22 and and CC cord-328289-3h3kmjlz 164 23 brain brain NN cord-328289-3h3kmjlz 164 24 infarction infarction NN cord-328289-3h3kmjlz 164 25 ( ( -LRB- cord-328289-3h3kmjlz 164 26 Inciardi Inciardi NNP cord-328289-3h3kmjlz 164 27 et et NNP cord-328289-3h3kmjlz 164 28 al al NNP cord-328289-3h3kmjlz 164 29 . . NNP cord-328289-3h3kmjlz 164 30 , , , cord-328289-3h3kmjlz 164 31 2020 2020 CD cord-328289-3h3kmjlz 164 32 ) ) -RRB- cord-328289-3h3kmjlz 164 33 . . . cord-328289-3h3kmjlz 165 1 A a DT cord-328289-3h3kmjlz 165 2 substantial substantial JJ cord-328289-3h3kmjlz 165 3 proportion proportion NN cord-328289-3h3kmjlz 165 4 of of IN cord-328289-3h3kmjlz 165 5 critically critically RB cord-328289-3h3kmjlz 165 6 ill ill JJ cord-328289-3h3kmjlz 165 7 patients patient NNS cord-328289-3h3kmjlz 165 8 with with IN cord-328289-3h3kmjlz 165 9 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 165 10 may may MD cord-328289-3h3kmjlz 165 11 also also RB cord-328289-3h3kmjlz 165 12 develop develop VB cord-328289-3h3kmjlz 165 13 secondary secondary JJ cord-328289-3h3kmjlz 165 14 bacteremia bacteremia NN cord-328289-3h3kmjlz 165 15 in in IN cord-328289-3h3kmjlz 165 16 addition addition NN cord-328289-3h3kmjlz 165 17 to to IN cord-328289-3h3kmjlz 165 18 the the DT cord-328289-3h3kmjlz 165 19 primary primary JJ cord-328289-3h3kmjlz 165 20 viral viral JJ cord-328289-3h3kmjlz 165 21 illness illness NN cord-328289-3h3kmjlz 165 22 . . . cord-328289-3h3kmjlz 166 1 In in IN cord-328289-3h3kmjlz 166 2 one one CD cord-328289-3h3kmjlz 166 3 case case NN cord-328289-3h3kmjlz 166 4 series series NN cord-328289-3h3kmjlz 166 5 , , , cord-328289-3h3kmjlz 166 6 approximately approximately RB cord-328289-3h3kmjlz 166 7 10 10 CD cord-328289-3h3kmjlz 166 8 % % NN cord-328289-3h3kmjlz 166 9 of of IN cord-328289-3h3kmjlz 166 10 patients patient NNS cord-328289-3h3kmjlz 166 11 requiring require VBG cord-328289-3h3kmjlz 166 12 mechanical mechanical JJ cord-328289-3h3kmjlz 166 13 ventilation ventilation NN cord-328289-3h3kmjlz 166 14 had have VBD cord-328289-3h3kmjlz 166 15 bacteremia bacteremia NN cord-328289-3h3kmjlz 166 16 , , , cord-328289-3h3kmjlz 166 17 which which WDT cord-328289-3h3kmjlz 166 18 increases increase VBZ cord-328289-3h3kmjlz 166 19 the the DT cord-328289-3h3kmjlz 166 20 risk risk NN cord-328289-3h3kmjlz 166 21 of of IN cord-328289-3h3kmjlz 166 22 stroke stroke NN cord-328289-3h3kmjlz 166 23 by by IN cord-328289-3h3kmjlz 166 24 over over IN cord-328289-3h3kmjlz 166 25 20 20 CD cord-328289-3h3kmjlz 166 26 folds fold NNS cord-328289-3h3kmjlz 166 27 ( ( -LRB- cord-328289-3h3kmjlz 166 28 Dalager Dalager NNP cord-328289-3h3kmjlz 166 29 - - HYPH cord-328289-3h3kmjlz 166 30 Pedersen Pedersen NNP cord-328289-3h3kmjlz 166 31 et et NNP cord-328289-3h3kmjlz 166 32 al al NNP cord-328289-3h3kmjlz 166 33 . . NNP cord-328289-3h3kmjlz 166 34 , , , cord-328289-3h3kmjlz 166 35 2014 2014 CD cord-328289-3h3kmjlz 166 36 ) ) -RRB- cord-328289-3h3kmjlz 166 37 . . . cord-328289-3h3kmjlz 167 1 Septic septic JJ cord-328289-3h3kmjlz 167 2 emboli embolus NNS cord-328289-3h3kmjlz 167 3 to to IN cord-328289-3h3kmjlz 167 4 the the DT cord-328289-3h3kmjlz 167 5 brain brain NN cord-328289-3h3kmjlz 167 6 often often RB cord-328289-3h3kmjlz 167 7 result result VBP cord-328289-3h3kmjlz 167 8 in in IN cord-328289-3h3kmjlz 167 9 bleeding bleeding NN cord-328289-3h3kmjlz 167 10 and and CC cord-328289-3h3kmjlz 167 11 in in IN cord-328289-3h3kmjlz 167 12 a a DT cord-328289-3h3kmjlz 167 13 postmortem postmortem JJ cord-328289-3h3kmjlz 167 14 magnetic magnetic JJ cord-328289-3h3kmjlz 167 15 resonance resonance NN cord-328289-3h3kmjlz 167 16 imaging imaging NN cord-328289-3h3kmjlz 167 17 study10 study10 CD cord-328289-3h3kmjlz 167 18 % % NN cord-328289-3h3kmjlz 167 19 of of IN cord-328289-3h3kmjlz 167 20 brains brain NNS cord-328289-3h3kmjlz 167 21 had have VBD cord-328289-3h3kmjlz 167 22 evidence evidence NN cord-328289-3h3kmjlz 167 23 of of IN cord-328289-3h3kmjlz 167 24 hemorrhage hemorrhage NN cord-328289-3h3kmjlz 168 1 ( ( -LRB- cord-328289-3h3kmjlz 168 2 Coolen Coolen NNP cord-328289-3h3kmjlz 168 3 et et NNP cord-328289-3h3kmjlz 168 4 al al NNP cord-328289-3h3kmjlz 168 5 . . NNP cord-328289-3h3kmjlz 168 6 , , , cord-328289-3h3kmjlz 168 7 2020 2020 CD cord-328289-3h3kmjlz 168 8 ) ) -RRB- cord-328289-3h3kmjlz 169 1 .Taken .taken CD cord-328289-3h3kmjlz 170 1 together together RB cord-328289-3h3kmjlz 170 2 , , , cord-328289-3h3kmjlz 170 3 these these DT cord-328289-3h3kmjlz 170 4 clinical clinical JJ cord-328289-3h3kmjlz 170 5 findings finding NNS cord-328289-3h3kmjlz 170 6 suggest suggest VBP cord-328289-3h3kmjlz 170 7 that that IN cord-328289-3h3kmjlz 170 8 SARS SARS NNP cord-328289-3h3kmjlz 170 9 - - HYPH cord-328289-3h3kmjlz 170 10 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 170 11 may may MD cord-328289-3h3kmjlz 170 12 adversely adversely RB cord-328289-3h3kmjlz 170 13 affect affect VB cord-328289-3h3kmjlz 170 14 the the DT cord-328289-3h3kmjlz 170 15 brain brain NN cord-328289-3h3kmjlz 170 16 via via IN cord-328289-3h3kmjlz 170 17 multiple multiple JJ cord-328289-3h3kmjlz 170 18 pathophysiological pathophysiological JJ cord-328289-3h3kmjlz 170 19 pathways pathway NNS cord-328289-3h3kmjlz 170 20 that that WDT cord-328289-3h3kmjlz 170 21 culminate culminate VBP cord-328289-3h3kmjlz 170 22 in in IN cord-328289-3h3kmjlz 170 23 vascular vascular JJ cord-328289-3h3kmjlz 170 24 brain brain NN cord-328289-3h3kmjlz 170 25 injury injury NN cord-328289-3h3kmjlz 170 26 . . . cord-328289-3h3kmjlz 171 1 Post post JJ cord-328289-3h3kmjlz 171 2 - - JJ cord-328289-3h3kmjlz 171 3 infectious infectious JJ cord-328289-3h3kmjlz 171 4 neurological neurological JJ cord-328289-3h3kmjlz 171 5 complications complication NNS cord-328289-3h3kmjlz 171 6 : : : cord-328289-3h3kmjlz 171 7 SARS SARS NNP cord-328289-3h3kmjlz 171 8 - - HYPH cord-328289-3h3kmjlz 171 9 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 171 10 unleashes unleash VBZ cord-328289-3h3kmjlz 171 11 a a DT cord-328289-3h3kmjlz 171 12 dysregulated dysregulate VBN cord-328289-3h3kmjlz 171 13 systemic systemic JJ cord-328289-3h3kmjlz 171 14 immune immune JJ cord-328289-3h3kmjlz 171 15 response response NN cord-328289-3h3kmjlz 171 16 ( ( -LRB- cord-328289-3h3kmjlz 171 17 see see VB cord-328289-3h3kmjlz 171 18 Systemic systemic JJ cord-328289-3h3kmjlz 171 19 inflammation inflammation NN cord-328289-3h3kmjlz 171 20 and and CC cord-328289-3h3kmjlz 171 21 immune immune JJ cord-328289-3h3kmjlz 171 22 dysregulation dysregulation NN cord-328289-3h3kmjlz 171 23 ) ) -RRB- cord-328289-3h3kmjlz 171 24 , , , cord-328289-3h3kmjlz 171 25 which which WDT cord-328289-3h3kmjlz 171 26 can can MD cord-328289-3h3kmjlz 171 27 have have VB cord-328289-3h3kmjlz 171 28 delayed delay VBN cord-328289-3h3kmjlz 171 29 effects effect NNS cord-328289-3h3kmjlz 171 30 on on IN cord-328289-3h3kmjlz 171 31 the the DT cord-328289-3h3kmjlz 171 32 nervous nervous JJ cord-328289-3h3kmjlz 171 33 system system NN cord-328289-3h3kmjlz 171 34 . . . cord-328289-3h3kmjlz 172 1 These these DT cord-328289-3h3kmjlz 172 2 immune immune NN cord-328289-3h3kmjlz 172 3 - - HYPH cord-328289-3h3kmjlz 172 4 mediated mediate VBN cord-328289-3h3kmjlz 172 5 manifestations manifestation NNS cord-328289-3h3kmjlz 172 6 involve involve VBP cord-328289-3h3kmjlz 172 7 both both CC cord-328289-3h3kmjlz 172 8 the the DT cord-328289-3h3kmjlz 172 9 central central JJ cord-328289-3h3kmjlz 172 10 and and CC cord-328289-3h3kmjlz 172 11 peripheral peripheral JJ cord-328289-3h3kmjlz 172 12 nervous nervous JJ cord-328289-3h3kmjlz 172 13 system system NN cord-328289-3h3kmjlz 172 14 and and CC cord-328289-3h3kmjlz 172 15 occur occur VBP cord-328289-3h3kmjlz 172 16 typically typically RB cord-328289-3h3kmjlz 172 17 after after IN cord-328289-3h3kmjlz 172 18 the the DT cord-328289-3h3kmjlz 172 19 acute acute JJ cord-328289-3h3kmjlz 172 20 phase phase NN cord-328289-3h3kmjlz 172 21 of of IN cord-328289-3h3kmjlz 172 22 the the DT cord-328289-3h3kmjlz 172 23 infection infection NN cord-328289-3h3kmjlz 172 24 subsides subside VBZ cord-328289-3h3kmjlz 172 25 . . . cord-328289-3h3kmjlz 173 1 In in IN cord-328289-3h3kmjlz 173 2 the the DT cord-328289-3h3kmjlz 173 3 CNS CNS NNP cord-328289-3h3kmjlz 173 4 , , , cord-328289-3h3kmjlz 173 5 reported report VBD cord-328289-3h3kmjlz 173 6 cases case NNS cord-328289-3h3kmjlz 173 7 in in IN cord-328289-3h3kmjlz 173 8 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 173 9 resemble resemble JJ cord-328289-3h3kmjlz 173 10 classic classic JJ cord-328289-3h3kmjlz 173 11 post post JJ cord-328289-3h3kmjlz 173 12 - - JJ cord-328289-3h3kmjlz 173 13 infectious infectious JJ cord-328289-3h3kmjlz 173 14 inflammatory inflammatory JJ cord-328289-3h3kmjlz 173 15 conditions condition NNS cord-328289-3h3kmjlz 173 16 such such JJ cord-328289-3h3kmjlz 173 17 as as IN cord-328289-3h3kmjlz 173 18 acute acute JJ cord-328289-3h3kmjlz 173 19 disseminated disseminate VBN cord-328289-3h3kmjlz 173 20 encephalomyelitis encephalomyelitis NN cord-328289-3h3kmjlz 173 21 ( ( -LRB- cord-328289-3h3kmjlz 173 22 Parsons Parsons NNP cord-328289-3h3kmjlz 173 23 et et NNP cord-328289-3h3kmjlz 173 24 al al NNP cord-328289-3h3kmjlz 173 25 . . NNP cord-328289-3h3kmjlz 173 26 , , , cord-328289-3h3kmjlz 173 27 2020 2020 CD cord-328289-3h3kmjlz 173 28 ) ) -RRB- cord-328289-3h3kmjlz 173 29 and and CC cord-328289-3h3kmjlz 173 30 acute acute JJ cord-328289-3h3kmjlz 173 31 necrotizing necrotize VBG cord-328289-3h3kmjlz 173 32 hemorrhagic hemorrhagic JJ cord-328289-3h3kmjlz 173 33 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 173 34 ( ( -LRB- cord-328289-3h3kmjlz 173 35 Poyiadji Poyiadji NNP cord-328289-3h3kmjlz 173 36 et et FW cord-328289-3h3kmjlz 173 37 al al NNP cord-328289-3h3kmjlz 173 38 . . NNP cord-328289-3h3kmjlz 173 39 , , , cord-328289-3h3kmjlz 173 40 2020 2020 CD cord-328289-3h3kmjlz 173 41 ) ) -RRB- cord-328289-3h3kmjlz 173 42 . . . cord-328289-3h3kmjlz 174 1 Peripherally peripherally RB cord-328289-3h3kmjlz 174 2 , , , cord-328289-3h3kmjlz 174 3 several several JJ cord-328289-3h3kmjlz 174 4 cases case NNS cord-328289-3h3kmjlz 174 5 of of IN cord-328289-3h3kmjlz 174 6 Guillain Guillain NNP cord-328289-3h3kmjlz 174 7 - - HYPH cord-328289-3h3kmjlz 174 8 Barre Barre NNP cord-328289-3h3kmjlz 174 9 syndrome syndrome NN cord-328289-3h3kmjlz 174 10 , , , cord-328289-3h3kmjlz 174 11 a a DT cord-328289-3h3kmjlz 174 12 neuropathy neuropathy NN cord-328289-3h3kmjlz 174 13 caused cause VBN cord-328289-3h3kmjlz 174 14 by by IN cord-328289-3h3kmjlz 174 15 an an DT cord-328289-3h3kmjlz 174 16 immune immune JJ cord-328289-3h3kmjlz 174 17 attack attack NN cord-328289-3h3kmjlz 174 18 on on IN cord-328289-3h3kmjlz 174 19 peripheral peripheral JJ cord-328289-3h3kmjlz 174 20 nerves nerve NNS cord-328289-3h3kmjlz 174 21 , , , cord-328289-3h3kmjlz 174 22 have have VBP cord-328289-3h3kmjlz 174 23 been be VBN cord-328289-3h3kmjlz 174 24 reported report VBN cord-328289-3h3kmjlz 174 25 in in IN cord-328289-3h3kmjlz 174 26 patients patient NNS cord-328289-3h3kmjlz 174 27 with with IN cord-328289-3h3kmjlz 174 28 recent recent JJ cord-328289-3h3kmjlz 174 29 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 174 30 ( ( -LRB- cord-328289-3h3kmjlz 174 31 Toscano Toscano NNP cord-328289-3h3kmjlz 174 32 et et NNP cord-328289-3h3kmjlz 174 33 al al NNP cord-328289-3h3kmjlz 174 34 . . NNP cord-328289-3h3kmjlz 174 35 , , , cord-328289-3h3kmjlz 174 36 2020 2020 CD cord-328289-3h3kmjlz 174 37 ) ) -RRB- cord-328289-3h3kmjlz 174 38 . . . cord-328289-3h3kmjlz 175 1 Most most RBS cord-328289-3h3kmjlz 175 2 reported report VBN cord-328289-3h3kmjlz 175 3 cases case NNS cord-328289-3h3kmjlz 175 4 describe describe VBP cord-328289-3h3kmjlz 175 5 classic classic JJ cord-328289-3h3kmjlz 175 6 features feature NNS cord-328289-3h3kmjlz 175 7 of of IN cord-328289-3h3kmjlz 175 8 this this DT cord-328289-3h3kmjlz 175 9 syndrome syndrome NN cord-328289-3h3kmjlz 175 10 , , , cord-328289-3h3kmjlz 175 11 such such JJ cord-328289-3h3kmjlz 175 12 as as IN cord-328289-3h3kmjlz 175 13 generalized generalize VBN cord-328289-3h3kmjlz 175 14 weakness weakness NN cord-328289-3h3kmjlz 175 15 , , , cord-328289-3h3kmjlz 175 16 evidence evidence NN cord-328289-3h3kmjlz 175 17 of of IN cord-328289-3h3kmjlz 175 18 demyelination demyelination NN cord-328289-3h3kmjlz 175 19 on on IN cord-328289-3h3kmjlz 175 20 nerve nerve NN cord-328289-3h3kmjlz 175 21 conduction conduction NN cord-328289-3h3kmjlz 175 22 studies study NNS cord-328289-3h3kmjlz 175 23 and and CC cord-328289-3h3kmjlz 175 24 elevated elevated JJ cord-328289-3h3kmjlz 175 25 proteins protein NNS cord-328289-3h3kmjlz 175 26 without without IN cord-328289-3h3kmjlz 175 27 white white JJ cord-328289-3h3kmjlz 175 28 blood blood NN cord-328289-3h3kmjlz 175 29 cells cell NNS cord-328289-3h3kmjlz 175 30 in in IN cord-328289-3h3kmjlz 175 31 CSF CSF NNP cord-328289-3h3kmjlz 175 32 ( ( -LRB- cord-328289-3h3kmjlz 175 33 Toscano Toscano NNP cord-328289-3h3kmjlz 175 34 et et NNP cord-328289-3h3kmjlz 175 35 al al NNP cord-328289-3h3kmjlz 175 36 . . NNP cord-328289-3h3kmjlz 175 37 , , , cord-328289-3h3kmjlz 175 38 2020 2020 CD cord-328289-3h3kmjlz 175 39 ) ) -RRB- cord-328289-3h3kmjlz 175 40 . . . cord-328289-3h3kmjlz 176 1 The the DT cord-328289-3h3kmjlz 176 2 Miller Miller NNP cord-328289-3h3kmjlz 176 3 - - HYPH cord-328289-3h3kmjlz 176 4 Fisher Fisher NNP cord-328289-3h3kmjlz 176 5 variant variant NN cord-328289-3h3kmjlz 176 6 of of IN cord-328289-3h3kmjlz 176 7 Guillain Guillain NNP cord-328289-3h3kmjlz 176 8 - - HYPH cord-328289-3h3kmjlz 176 9 Barre Barre NNP cord-328289-3h3kmjlz 176 10 syndrome syndrome NN cord-328289-3h3kmjlz 176 11 , , , cord-328289-3h3kmjlz 176 12 characterized characterize VBN cord-328289-3h3kmjlz 176 13 by by IN cord-328289-3h3kmjlz 176 14 cranial cranial JJ cord-328289-3h3kmjlz 176 15 nerve nerve NN cord-328289-3h3kmjlz 176 16 involvement involvement NN cord-328289-3h3kmjlz 176 17 , , , cord-328289-3h3kmjlz 176 18 has have VBZ cord-328289-3h3kmjlz 176 19 also also RB cord-328289-3h3kmjlz 176 20 been be VBN cord-328289-3h3kmjlz 176 21 reported report VBN cord-328289-3h3kmjlz 176 22 , , , cord-328289-3h3kmjlz 176 23 including include VBG cord-328289-3h3kmjlz 176 24 at at RB cord-328289-3h3kmjlz 176 25 least least RBS cord-328289-3h3kmjlz 176 26 one one CD cord-328289-3h3kmjlz 176 27 case case NN cord-328289-3h3kmjlz 176 28 with with IN cord-328289-3h3kmjlz 176 29 detectable detectable JJ cord-328289-3h3kmjlz 176 30 anti anti JJ cord-328289-3h3kmjlz 176 31 - - JJ cord-328289-3h3kmjlz 176 32 ganglioside ganglioside JJ cord-328289-3h3kmjlz 176 33 antibodies antibody NNS cord-328289-3h3kmjlz 176 34 suggesting suggest VBG cord-328289-3h3kmjlz 176 35 an an DT cord-328289-3h3kmjlz 176 36 immune immune JJ cord-328289-3h3kmjlz 176 37 attack attack NN cord-328289-3h3kmjlz 176 38 on on IN cord-328289-3h3kmjlz 176 39 the the DT cord-328289-3h3kmjlz 176 40 peripheral peripheral JJ cord-328289-3h3kmjlz 176 41 nerves nerve NNS cord-328289-3h3kmjlz 176 42 ( ( -LRB- cord-328289-3h3kmjlz 176 43 Gutierrez Gutierrez NNP cord-328289-3h3kmjlz 176 44 - - HYPH cord-328289-3h3kmjlz 176 45 Ortiz Ortiz NNP cord-328289-3h3kmjlz 176 46 et et NNP cord-328289-3h3kmjlz 176 47 al al NNP cord-328289-3h3kmjlz 176 48 . . NNP cord-328289-3h3kmjlz 176 49 , , , cord-328289-3h3kmjlz 176 50 2020 2020 CD cord-328289-3h3kmjlz 176 51 ) ) -RRB- cord-328289-3h3kmjlz 176 52 . . . cord-328289-3h3kmjlz 177 1 SARS SARS NNP cord-328289-3h3kmjlz 177 2 - - HYPH cord-328289-3h3kmjlz 177 3 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 177 4 was be VBD cord-328289-3h3kmjlz 177 5 not not RB cord-328289-3h3kmjlz 177 6 detected detect VBN cord-328289-3h3kmjlz 177 7 in in IN cord-328289-3h3kmjlz 177 8 any any DT cord-328289-3h3kmjlz 177 9 of of IN cord-328289-3h3kmjlz 177 10 the the DT cord-328289-3h3kmjlz 177 11 CSF CSF NNP cord-328289-3h3kmjlz 177 12 samples sample NNS cord-328289-3h3kmjlz 177 13 ( ( -LRB- cord-328289-3h3kmjlz 177 14 Toscano Toscano NNP cord-328289-3h3kmjlz 177 15 et et NNP cord-328289-3h3kmjlz 177 16 al al NNP cord-328289-3h3kmjlz 177 17 . . NNP cord-328289-3h3kmjlz 177 18 , , , cord-328289-3h3kmjlz 177 19 2020 2020 CD cord-328289-3h3kmjlz 177 20 ) ) -RRB- cord-328289-3h3kmjlz 177 21 , , , cord-328289-3h3kmjlz 177 22 supporting support VBG cord-328289-3h3kmjlz 177 23 an an DT cord-328289-3h3kmjlz 177 24 immune immune JJ cord-328289-3h3kmjlz 177 25 mechanism mechanism NN cord-328289-3h3kmjlz 177 26 rather rather RB cord-328289-3h3kmjlz 177 27 than than IN cord-328289-3h3kmjlz 177 28 direct direct JJ cord-328289-3h3kmjlz 177 29 infection infection NN cord-328289-3h3kmjlz 177 30 . . . cord-328289-3h3kmjlz 178 1 Intensive intensive JJ cord-328289-3h3kmjlz 178 2 care care NN cord-328289-3h3kmjlz 178 3 related relate VBD cord-328289-3h3kmjlz 178 4 neurological neurological JJ cord-328289-3h3kmjlz 178 5 manifestations manifestation NNS cord-328289-3h3kmjlz 178 6 : : : cord-328289-3h3kmjlz 179 1 The the DT cord-328289-3h3kmjlz 179 2 relatively relatively RB cord-328289-3h3kmjlz 179 3 high high JJ cord-328289-3h3kmjlz 179 4 frequency frequency NN cord-328289-3h3kmjlz 179 5 of of IN cord-328289-3h3kmjlz 179 6 altered altered JJ cord-328289-3h3kmjlz 179 7 mental mental JJ cord-328289-3h3kmjlz 179 8 status status NN cord-328289-3h3kmjlz 179 9 in in IN cord-328289-3h3kmjlz 179 10 hospitalized hospitalize VBN cord-328289-3h3kmjlz 179 11 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 179 12 patients patient NNS cord-328289-3h3kmjlz 179 13 is be VBZ cord-328289-3h3kmjlz 179 14 congruent congruent JJ cord-328289-3h3kmjlz 179 15 with with IN cord-328289-3h3kmjlz 179 16 the the DT cord-328289-3h3kmjlz 179 17 severity severity NN cord-328289-3h3kmjlz 179 18 of of IN cord-328289-3h3kmjlz 179 19 their -PRON- PRP$ cord-328289-3h3kmjlz 179 20 illness illness NN cord-328289-3h3kmjlz 179 21 . . . cord-328289-3h3kmjlz 180 1 Most most RBS cord-328289-3h3kmjlz 180 2 critically critically RB cord-328289-3h3kmjlz 180 3 ill ill JJ cord-328289-3h3kmjlz 181 1 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 181 2 patients patient NNS cord-328289-3h3kmjlz 181 3 require require VBP cord-328289-3h3kmjlz 181 4 mechanical mechanical JJ cord-328289-3h3kmjlz 181 5 ventilation ventilation NN cord-328289-3h3kmjlz 182 1 ( ( -LRB- cord-328289-3h3kmjlz 182 2 Cummings Cummings NNP cord-328289-3h3kmjlz 182 3 et et FW cord-328289-3h3kmjlz 182 4 al al NNP cord-328289-3h3kmjlz 182 5 . . NNP cord-328289-3h3kmjlz 182 6 , , , cord-328289-3h3kmjlz 182 7 2020 2020 CD cord-328289-3h3kmjlz 182 8 ) ) -RRB- cord-328289-3h3kmjlz 182 9 and and CC cord-328289-3h3kmjlz 182 10 an an DT cord-328289-3h3kmjlz 182 11 agitated agitated JJ cord-328289-3h3kmjlz 182 12 confusional confusional JJ cord-328289-3h3kmjlz 182 13 state state NN cord-328289-3h3kmjlz 182 14 ( ( -LRB- cord-328289-3h3kmjlz 182 15 delirium delirium NN cord-328289-3h3kmjlz 182 16 ) ) -RRB- cord-328289-3h3kmjlz 182 17 occurs occur VBZ cord-328289-3h3kmjlz 182 18 in in IN cord-328289-3h3kmjlz 182 19 more more JJR cord-328289-3h3kmjlz 182 20 than than IN cord-328289-3h3kmjlz 182 21 80 80 CD cord-328289-3h3kmjlz 182 22 % % NN cord-328289-3h3kmjlz 182 23 of of IN cord-328289-3h3kmjlz 182 24 mechanically mechanically RB cord-328289-3h3kmjlz 182 25 ventilated ventilate VBN cord-328289-3h3kmjlz 182 26 patients patient NNS cord-328289-3h3kmjlz 182 27 in in IN cord-328289-3h3kmjlz 182 28 intensive intensive JJ cord-328289-3h3kmjlz 182 29 care care NN cord-328289-3h3kmjlz 182 30 units unit NNS cord-328289-3h3kmjlz 183 1 ( ( -LRB- cord-328289-3h3kmjlz 183 2 Ely Ely NNP cord-328289-3h3kmjlz 183 3 et et NNP cord-328289-3h3kmjlz 183 4 al al NNP cord-328289-3h3kmjlz 183 5 . . NNP cord-328289-3h3kmjlz 183 6 , , , cord-328289-3h3kmjlz 183 7 2001 2001 CD cord-328289-3h3kmjlz 183 8 ) ) -RRB- cord-328289-3h3kmjlz 183 9 . . . cord-328289-3h3kmjlz 184 1 Patients patient NNS cord-328289-3h3kmjlz 184 2 with with IN cord-328289-3h3kmjlz 184 3 ARDS ARDS NNP cord-328289-3h3kmjlz 184 4 , , , cord-328289-3h3kmjlz 184 5 which which WDT cord-328289-3h3kmjlz 184 6 frequently frequently RB cord-328289-3h3kmjlz 184 7 complicates complicate VBZ cord-328289-3h3kmjlz 184 8 severe severe JJ cord-328289-3h3kmjlz 184 9 COVID-19 covid-19 NN cord-328289-3h3kmjlz 184 10 , , , cord-328289-3h3kmjlz 184 11 are be VBP cord-328289-3h3kmjlz 184 12 at at IN cord-328289-3h3kmjlz 184 13 particularly particularly RB cord-328289-3h3kmjlz 184 14 high high JJ cord-328289-3h3kmjlz 184 15 risk risk NN cord-328289-3h3kmjlz 184 16 of of IN cord-328289-3h3kmjlz 184 17 delirium delirium NN cord-328289-3h3kmjlz 184 18 , , , cord-328289-3h3kmjlz 184 19 likely likely RB cord-328289-3h3kmjlz 184 20 because because IN cord-328289-3h3kmjlz 184 21 of of IN cord-328289-3h3kmjlz 184 22 hypoxemia hypoxemia NN cord-328289-3h3kmjlz 184 23 heavy heavy JJ cord-328289-3h3kmjlz 184 24 doses dose NNS cord-328289-3h3kmjlz 184 25 of of IN cord-328289-3h3kmjlz 184 26 sedatives sedative NNS cord-328289-3h3kmjlz 184 27 , , , cord-328289-3h3kmjlz 184 28 administration administration NN cord-328289-3h3kmjlz 184 29 of of IN cord-328289-3h3kmjlz 184 30 paralytic paralytic JJ cord-328289-3h3kmjlz 184 31 agents agent NNS cord-328289-3h3kmjlz 184 32 or or CC cord-328289-3h3kmjlz 184 33 other other JJ cord-328289-3h3kmjlz 184 34 causes cause NNS cord-328289-3h3kmjlz 184 35 ( ( -LRB- cord-328289-3h3kmjlz 185 1 Hopkins Hopkins NNP cord-328289-3h3kmjlz 185 2 et et NNP cord-328289-3h3kmjlz 185 3 al al NNP cord-328289-3h3kmjlz 185 4 . . . cord-328289-3h3kmjlz 186 1 , , , cord-328289-3h3kmjlz 186 2 2005 2005 CD cord-328289-3h3kmjlz 186 3 ; ; : cord-328289-3h3kmjlz 186 4 Ouimet Ouimet NNP cord-328289-3h3kmjlz 186 5 et et NNP cord-328289-3h3kmjlz 186 6 al al NNP cord-328289-3h3kmjlz 186 7 . . NNP cord-328289-3h3kmjlz 186 8 , , , cord-328289-3h3kmjlz 186 9 2007 2007 CD cord-328289-3h3kmjlz 186 10 ) ) -RRB- cord-328289-3h3kmjlz 186 11 . . . cord-328289-3h3kmjlz 187 1 Comparison comparison NN cord-328289-3h3kmjlz 187 2 with with IN cord-328289-3h3kmjlz 187 3 other other JJ cord-328289-3h3kmjlz 187 4 viral viral JJ cord-328289-3h3kmjlz 187 5 respiratory respiratory JJ cord-328289-3h3kmjlz 187 6 infections infection NNS cord-328289-3h3kmjlz 187 7 : : : cord-328289-3h3kmjlz 188 1 Many many JJ cord-328289-3h3kmjlz 188 2 neurological neurological JJ cord-328289-3h3kmjlz 188 3 abnormalities abnormality NNS cord-328289-3h3kmjlz 188 4 seen see VBN cord-328289-3h3kmjlz 188 5 in in IN cord-328289-3h3kmjlz 188 6 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 188 7 mirror mirror NN cord-328289-3h3kmjlz 188 8 those those DT cord-328289-3h3kmjlz 188 9 of of IN cord-328289-3h3kmjlz 188 10 other other JJ cord-328289-3h3kmjlz 188 11 viral viral JJ cord-328289-3h3kmjlz 188 12 respiratory respiratory JJ cord-328289-3h3kmjlz 188 13 illnesses illness NNS cord-328289-3h3kmjlz 188 14 . . . cord-328289-3h3kmjlz 189 1 All all DT cord-328289-3h3kmjlz 189 2 of of IN cord-328289-3h3kmjlz 189 3 the the DT cord-328289-3h3kmjlz 189 4 reported report VBN cord-328289-3h3kmjlz 189 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 189 6 related related JJ cord-328289-3h3kmjlz 189 7 post post JJ cord-328289-3h3kmjlz 189 8 - - JJ cord-328289-3h3kmjlz 189 9 infectious infectious JJ cord-328289-3h3kmjlz 189 10 inflammatory inflammatory JJ cord-328289-3h3kmjlz 189 11 conditions condition NNS cord-328289-3h3kmjlz 189 12 of of IN cord-328289-3h3kmjlz 189 13 the the DT cord-328289-3h3kmjlz 189 14 nervous nervous JJ cord-328289-3h3kmjlz 189 15 system system NN cord-328289-3h3kmjlz 189 16 , , , cord-328289-3h3kmjlz 189 17 such such JJ cord-328289-3h3kmjlz 189 18 as as IN cord-328289-3h3kmjlz 189 19 Guillain Guillain NNP cord-328289-3h3kmjlz 189 20 - - HYPH cord-328289-3h3kmjlz 189 21 Barre Barre NNP cord-328289-3h3kmjlz 189 22 syndrome syndrome NN cord-328289-3h3kmjlz 189 23 , , , cord-328289-3h3kmjlz 189 24 acute acute JJ cord-328289-3h3kmjlz 189 25 necrotizing necrotize VBG cord-328289-3h3kmjlz 189 26 hemorrhagic hemorrhagic JJ cord-328289-3h3kmjlz 189 27 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 189 28 and and CC cord-328289-3h3kmjlz 189 29 acute acute JJ cord-328289-3h3kmjlz 189 30 disseminated disseminate VBN cord-328289-3h3kmjlz 189 31 encephalomyelitis encephalomyelitis NN cord-328289-3h3kmjlz 189 32 , , , cord-328289-3h3kmjlz 189 33 are be VBP cord-328289-3h3kmjlz 189 34 classically classically RB cord-328289-3h3kmjlz 189 35 seen see VBN cord-328289-3h3kmjlz 189 36 after after IN cord-328289-3h3kmjlz 189 37 infections infection NNS cord-328289-3h3kmjlz 189 38 , , , cord-328289-3h3kmjlz 189 39 including include VBG cord-328289-3h3kmjlz 189 40 other other JJ cord-328289-3h3kmjlz 189 41 coronaviruses coronaviruse NNS cord-328289-3h3kmjlz 189 42 ( ( -LRB- cord-328289-3h3kmjlz 189 43 Gerges Gerges NNP cord-328289-3h3kmjlz 189 44 Harb Harb NNP cord-328289-3h3kmjlz 189 45 et et NNP cord-328289-3h3kmjlz 189 46 al al NNP cord-328289-3h3kmjlz 189 47 . . NNP cord-328289-3h3kmjlz 189 48 , , , cord-328289-3h3kmjlz 189 49 2020 2020 CD cord-328289-3h3kmjlz 189 50 ) ) -RRB- cord-328289-3h3kmjlz 189 51 . . . cord-328289-3h3kmjlz 190 1 Influenza influenza NN cord-328289-3h3kmjlz 190 2 is be VBZ cord-328289-3h3kmjlz 190 3 occasionally occasionally RB cord-328289-3h3kmjlz 190 4 associated associate VBN cord-328289-3h3kmjlz 190 5 with with IN cord-328289-3h3kmjlz 190 6 an an DT cord-328289-3h3kmjlz 190 7 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 190 8 or or CC cord-328289-3h3kmjlz 190 9 full full JJ cord-328289-3h3kmjlz 190 10 blown blow VBN cord-328289-3h3kmjlz 190 11 encephalitis encephalitis RB cord-328289-3h3kmjlz 190 12 , , , cord-328289-3h3kmjlz 190 13 with with IN cord-328289-3h3kmjlz 190 14 evidence evidence NN cord-328289-3h3kmjlz 190 15 of of IN cord-328289-3h3kmjlz 190 16 influenza influenza NN cord-328289-3h3kmjlz 190 17 virus virus NN cord-328289-3h3kmjlz 190 18 in in IN cord-328289-3h3kmjlz 190 19 the the DT cord-328289-3h3kmjlz 190 20 cerebrospinal cerebrospinal JJ cord-328289-3h3kmjlz 190 21 fluid fluid NN cord-328289-3h3kmjlz 190 22 ( ( -LRB- cord-328289-3h3kmjlz 190 23 Surtees Surtees NNP cord-328289-3h3kmjlz 190 24 and and CC cord-328289-3h3kmjlz 190 25 DeSousa DeSousa NNP cord-328289-3h3kmjlz 190 26 , , , cord-328289-3h3kmjlz 190 27 2006 2006 CD cord-328289-3h3kmjlz 190 28 ) ) -RRB- cord-328289-3h3kmjlz 190 29 . . . cord-328289-3h3kmjlz 191 1 Comparing compare VBG cord-328289-3h3kmjlz 191 2 the the DT cord-328289-3h3kmjlz 191 3 large large JJ cord-328289-3h3kmjlz 191 4 numbers number NNS cord-328289-3h3kmjlz 191 5 of of IN cord-328289-3h3kmjlz 191 6 patients patient NNS cord-328289-3h3kmjlz 191 7 infected infect VBN cord-328289-3h3kmjlz 191 8 by by IN cord-328289-3h3kmjlz 191 9 SARS SARS NNP cord-328289-3h3kmjlz 191 10 - - HYPH cord-328289-3h3kmjlz 191 11 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 191 12 worldwide worldwide RB cord-328289-3h3kmjlz 191 13 and and CC cord-328289-3h3kmjlz 191 14 the the DT cord-328289-3h3kmjlz 191 15 relative relative JJ cord-328289-3h3kmjlz 191 16 paucity paucity NN cord-328289-3h3kmjlz 191 17 of of IN cord-328289-3h3kmjlz 191 18 reported report VBN cord-328289-3h3kmjlz 191 19 encephalitis encephalitis JJ cord-328289-3h3kmjlz 191 20 cases case NNS cord-328289-3h3kmjlz 191 21 , , , cord-328289-3h3kmjlz 191 22 SARS SARS NNP cord-328289-3h3kmjlz 191 23 - - HYPH cord-328289-3h3kmjlz 191 24 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 191 25 seems seem VBZ cord-328289-3h3kmjlz 191 26 more more RBR cord-328289-3h3kmjlz 191 27 similar similar JJ cord-328289-3h3kmjlz 191 28 to to IN cord-328289-3h3kmjlz 191 29 other other JJ cord-328289-3h3kmjlz 191 30 common common JJ cord-328289-3h3kmjlz 191 31 respiratory respiratory JJ cord-328289-3h3kmjlz 191 32 viral viral JJ cord-328289-3h3kmjlz 191 33 pathogens pathogen NNS cord-328289-3h3kmjlz 191 34 like like IN cord-328289-3h3kmjlz 191 35 influenza influenza NN cord-328289-3h3kmjlz 191 36 than than IN cord-328289-3h3kmjlz 191 37 to to IN cord-328289-3h3kmjlz 191 38 neurotropic neurotropic NNP cord-328289-3h3kmjlz 191 39 pathogens pathogen NNS cord-328289-3h3kmjlz 191 40 that that WDT cord-328289-3h3kmjlz 191 41 target target VBP cord-328289-3h3kmjlz 191 42 specifically specifically RB cord-328289-3h3kmjlz 191 43 the the DT cord-328289-3h3kmjlz 191 44 brain brain NN cord-328289-3h3kmjlz 191 45 , , , cord-328289-3h3kmjlz 191 46 such such JJ cord-328289-3h3kmjlz 191 47 as as IN cord-328289-3h3kmjlz 191 48 the the DT cord-328289-3h3kmjlz 191 49 herpes herpes NNP cord-328289-3h3kmjlz 191 50 simplex simplex NNP cord-328289-3h3kmjlz 191 51 virus virus NN cord-328289-3h3kmjlz 191 52 . . . cord-328289-3h3kmjlz 192 1 In in IN cord-328289-3h3kmjlz 192 2 general general JJ cord-328289-3h3kmjlz 192 3 , , , cord-328289-3h3kmjlz 192 4 however however RB cord-328289-3h3kmjlz 192 5 , , , cord-328289-3h3kmjlz 192 6 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 192 7 is be VBZ cord-328289-3h3kmjlz 192 8 more more RBR cord-328289-3h3kmjlz 192 9 debilitating debilitating JJ cord-328289-3h3kmjlz 192 10 than than IN cord-328289-3h3kmjlz 192 11 other other JJ cord-328289-3h3kmjlz 192 12 common common JJ cord-328289-3h3kmjlz 192 13 viral viral JJ cord-328289-3h3kmjlz 192 14 respiratory respiratory JJ cord-328289-3h3kmjlz 192 15 illnesses illness NNS cord-328289-3h3kmjlz 192 16 . . . cord-328289-3h3kmjlz 193 1 Physicians physician NNS cord-328289-3h3kmjlz 193 2 have have VBP cord-328289-3h3kmjlz 193 3 been be VBN cord-328289-3h3kmjlz 193 4 struck strike VBN cord-328289-3h3kmjlz 193 5 by by IN cord-328289-3h3kmjlz 193 6 the the DT cord-328289-3h3kmjlz 193 7 frequency frequency NN cord-328289-3h3kmjlz 193 8 of of IN cord-328289-3h3kmjlz 193 9 thrombotic thrombotic JJ cord-328289-3h3kmjlz 193 10 complications complication NNS cord-328289-3h3kmjlz 193 11 observed observe VBN cord-328289-3h3kmjlz 193 12 in in IN cord-328289-3h3kmjlz 193 13 critically critically RB cord-328289-3h3kmjlz 193 14 ill ill JJ cord-328289-3h3kmjlz 193 15 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 193 16 patients patient NNS cord-328289-3h3kmjlz 193 17 , , , cord-328289-3h3kmjlz 193 18 to to IN cord-328289-3h3kmjlz 193 19 the the DT cord-328289-3h3kmjlz 193 20 point point NN cord-328289-3h3kmjlz 193 21 that that IN cord-328289-3h3kmjlz 193 22 some some DT cord-328289-3h3kmjlz 193 23 hospitals hospital NNS cord-328289-3h3kmjlz 193 24 instituted institute VBD cord-328289-3h3kmjlz 193 25 protocols protocol NNS cord-328289-3h3kmjlz 193 26 for for IN cord-328289-3h3kmjlz 193 27 empiric empiric JJ cord-328289-3h3kmjlz 193 28 , , , cord-328289-3h3kmjlz 193 29 high high JJ cord-328289-3h3kmjlz 193 30 - - HYPH cord-328289-3h3kmjlz 193 31 dose dose NN cord-328289-3h3kmjlz 193 32 anticoagulation anticoagulation NN cord-328289-3h3kmjlz 193 33 in in IN cord-328289-3h3kmjlz 193 34 patients patient NNS cord-328289-3h3kmjlz 193 35 with with IN cord-328289-3h3kmjlz 193 36 elevated elevated JJ cord-328289-3h3kmjlz 193 37 D d NN cord-328289-3h3kmjlz 193 38 - - HYPH cord-328289-3h3kmjlz 193 39 dimer dimer NN cord-328289-3h3kmjlz 193 40 levels level NNS cord-328289-3h3kmjlz 193 41 ( ( -LRB- cord-328289-3h3kmjlz 193 42 Paranjpe Paranjpe NNP cord-328289-3h3kmjlz 193 43 et et NNP cord-328289-3h3kmjlz 193 44 al al NNP cord-328289-3h3kmjlz 193 45 . . NNP cord-328289-3h3kmjlz 193 46 , , , cord-328289-3h3kmjlz 193 47 2020 2020 CD cord-328289-3h3kmjlz 193 48 ) ) -RRB- cord-328289-3h3kmjlz 193 49 . . . cord-328289-3h3kmjlz 194 1 Emerging emerge VBG cord-328289-3h3kmjlz 194 2 data datum NNS cord-328289-3h3kmjlz 194 3 seem seem VBP cord-328289-3h3kmjlz 194 4 to to TO cord-328289-3h3kmjlz 194 5 confirm confirm VB cord-328289-3h3kmjlz 194 6 this this DT cord-328289-3h3kmjlz 194 7 observation observation NN cord-328289-3h3kmjlz 194 8 : : : cord-328289-3h3kmjlz 194 9 in in IN cord-328289-3h3kmjlz 194 10 one one CD cord-328289-3h3kmjlz 194 11 multicenter multicenter JJ cord-328289-3h3kmjlz 194 12 study study NN cord-328289-3h3kmjlz 194 13 , , , cord-328289-3h3kmjlz 194 14 patients patient NNS cord-328289-3h3kmjlz 194 15 with with IN cord-328289-3h3kmjlz 194 16 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 194 17 and and CC cord-328289-3h3kmjlz 194 18 acute acute JJ cord-328289-3h3kmjlz 194 19 respiratory respiratory JJ cord-328289-3h3kmjlz 194 20 distress distress NN cord-328289-3h3kmjlz 194 21 syndrome syndrome NN cord-328289-3h3kmjlz 194 22 had have VBD cord-328289-3h3kmjlz 194 23 twice twice PDT cord-328289-3h3kmjlz 194 24 the the DT cord-328289-3h3kmjlz 194 25 incidence incidence NN cord-328289-3h3kmjlz 194 26 of of IN cord-328289-3h3kmjlz 194 27 thrombotic thrombotic JJ cord-328289-3h3kmjlz 194 28 complications complication NNS cord-328289-3h3kmjlz 194 29 compared compare VBN cord-328289-3h3kmjlz 194 30 to to IN cord-328289-3h3kmjlz 194 31 a a DT cord-328289-3h3kmjlz 194 32 matched match VBN cord-328289-3h3kmjlz 194 33 cohort cohort NN cord-328289-3h3kmjlz 194 34 with with IN cord-328289-3h3kmjlz 194 35 ARDS ARDS NNP cord-328289-3h3kmjlz 194 36 from from IN cord-328289-3h3kmjlz 194 37 other other JJ cord-328289-3h3kmjlz 194 38 causes cause NNS cord-328289-3h3kmjlz 194 39 ( ( -LRB- cord-328289-3h3kmjlz 194 40 Helms Helms NNP cord-328289-3h3kmjlz 194 41 et et NNP cord-328289-3h3kmjlz 194 42 al al NNP cord-328289-3h3kmjlz 194 43 . . NNP cord-328289-3h3kmjlz 194 44 , , , cord-328289-3h3kmjlz 194 45 2020b 2020b CD cord-328289-3h3kmjlz 194 46 ) ) -RRB- cord-328289-3h3kmjlz 194 47 . . . cord-328289-3h3kmjlz 195 1 This this DT cord-328289-3h3kmjlz 195 2 also also RB cord-328289-3h3kmjlz 195 3 applies apply VBZ cord-328289-3h3kmjlz 195 4 to to IN cord-328289-3h3kmjlz 195 5 thrombotic thrombotic JJ cord-328289-3h3kmjlz 195 6 complications complication NNS cord-328289-3h3kmjlz 195 7 affecting affect VBG cord-328289-3h3kmjlz 195 8 the the DT cord-328289-3h3kmjlz 195 9 brain brain NN cord-328289-3h3kmjlz 195 10 , , , cord-328289-3h3kmjlz 195 11 since since IN cord-328289-3h3kmjlz 195 12 the the DT cord-328289-3h3kmjlz 195 13 proportion proportion NN cord-328289-3h3kmjlz 195 14 of of IN cord-328289-3h3kmjlz 195 15 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 195 16 related related JJ cord-328289-3h3kmjlz 195 17 hospitalizations hospitalization NNS cord-328289-3h3kmjlz 195 18 complicated complicate VBN cord-328289-3h3kmjlz 195 19 by by IN cord-328289-3h3kmjlz 195 20 stroke stroke NN cord-328289-3h3kmjlz 195 21 seems seem VBZ cord-328289-3h3kmjlz 195 22 much much RB cord-328289-3h3kmjlz 195 23 higher high JJR cord-328289-3h3kmjlz 195 24 than than IN cord-328289-3h3kmjlz 195 25 that that DT cord-328289-3h3kmjlz 195 26 seen see VBN cord-328289-3h3kmjlz 195 27 in in IN cord-328289-3h3kmjlz 195 28 influenza influenza NN cord-328289-3h3kmjlz 195 29 . . . cord-328289-3h3kmjlz 196 1 Based base VBN cord-328289-3h3kmjlz 196 2 on on IN cord-328289-3h3kmjlz 196 3 neuroinflammation neuroinflammation NN cord-328289-3h3kmjlz 196 4 - - HYPH cord-328289-3h3kmjlz 196 5 associated associate VBN cord-328289-3h3kmjlz 196 6 abnormalities abnormality NNS cord-328289-3h3kmjlz 196 7 in in IN cord-328289-3h3kmjlz 196 8 the the DT cord-328289-3h3kmjlz 196 9 clotting clotting NN cord-328289-3h3kmjlz 196 10 cascade cascade NN cord-328289-3h3kmjlz 196 11 in in IN cord-328289-3h3kmjlz 196 12 brain brain NN cord-328289-3h3kmjlz 196 13 ( ( -LRB- cord-328289-3h3kmjlz 196 14 Han Han NNP cord-328289-3h3kmjlz 196 15 et et NNP cord-328289-3h3kmjlz 196 16 al al NNP cord-328289-3h3kmjlz 196 17 . . NNP cord-328289-3h3kmjlz 196 18 , , , cord-328289-3h3kmjlz 196 19 2008 2008 CD cord-328289-3h3kmjlz 196 20 ) ) -RRB- cord-328289-3h3kmjlz 196 21 , , , cord-328289-3h3kmjlz 196 22 activated activate VBD cord-328289-3h3kmjlz 196 23 protein protein NN cord-328289-3h3kmjlz 196 24 C c NN cord-328289-3h3kmjlz 196 25 or or CC cord-328289-3h3kmjlz 196 26 thrombin thrombin NN cord-328289-3h3kmjlz 196 27 inhibitors inhibitor NNS cord-328289-3h3kmjlz 196 28 could could MD cord-328289-3h3kmjlz 196 29 also also RB cord-328289-3h3kmjlz 196 30 be be VB cord-328289-3h3kmjlz 196 31 of of IN cord-328289-3h3kmjlz 196 32 therapeutic therapeutic JJ cord-328289-3h3kmjlz 196 33 value value NN cord-328289-3h3kmjlz 196 34 . . . cord-328289-3h3kmjlz 197 1 The the DT cord-328289-3h3kmjlz 197 2 findings finding NNS cord-328289-3h3kmjlz 197 3 reviewed review VBN cord-328289-3h3kmjlz 197 4 above above RB cord-328289-3h3kmjlz 197 5 indicate indicate VBP cord-328289-3h3kmjlz 197 6 that that IN cord-328289-3h3kmjlz 197 7 neurological neurological JJ cord-328289-3h3kmjlz 197 8 manifestations manifestation NNS cord-328289-3h3kmjlz 197 9 are be VBP cord-328289-3h3kmjlz 197 10 common common JJ cord-328289-3h3kmjlz 197 11 in in IN cord-328289-3h3kmjlz 197 12 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 197 13 and and CC cord-328289-3h3kmjlz 197 14 constitute constitute VBP cord-328289-3h3kmjlz 197 15 a a DT cord-328289-3h3kmjlz 197 16 defining define VBG cord-328289-3h3kmjlz 197 17 aspect aspect NN cord-328289-3h3kmjlz 197 18 of of IN cord-328289-3h3kmjlz 197 19 the the DT cord-328289-3h3kmjlz 197 20 symptomatology symptomatology NN cord-328289-3h3kmjlz 197 21 of of IN cord-328289-3h3kmjlz 197 22 the the DT cord-328289-3h3kmjlz 197 23 disease disease NN cord-328289-3h3kmjlz 197 24 . . . cord-328289-3h3kmjlz 198 1 A a DT cord-328289-3h3kmjlz 198 2 caveat caveat NN cord-328289-3h3kmjlz 198 3 is be VBZ cord-328289-3h3kmjlz 198 4 that that IN cord-328289-3h3kmjlz 198 5 most most RBS cord-328289-3h3kmjlz 198 6 clinical clinical JJ cord-328289-3h3kmjlz 198 7 data data NN cord-328289-3h3kmjlz 198 8 is be VBZ cord-328289-3h3kmjlz 198 9 derived derive VBN cord-328289-3h3kmjlz 198 10 from from IN cord-328289-3h3kmjlz 198 11 case case NN cord-328289-3h3kmjlz 198 12 series series NN cord-328289-3h3kmjlz 198 13 on on IN cord-328289-3h3kmjlz 198 14 patients patient NNS cord-328289-3h3kmjlz 198 15 ill ill JJ cord-328289-3h3kmjlz 198 16 enough enough RB cord-328289-3h3kmjlz 198 17 to to TO cord-328289-3h3kmjlz 198 18 require require VB cord-328289-3h3kmjlz 198 19 hospitalization hospitalization NN cord-328289-3h3kmjlz 198 20 at at IN cord-328289-3h3kmjlz 198 21 tertiary tertiary JJ cord-328289-3h3kmjlz 198 22 care care NN cord-328289-3h3kmjlz 198 23 centers center NNS cord-328289-3h3kmjlz 198 24 , , , cord-328289-3h3kmjlz 198 25 providing provide VBG cord-328289-3h3kmjlz 198 26 a a DT cord-328289-3h3kmjlz 198 27 biased biased JJ cord-328289-3h3kmjlz 198 28 representation representation NN cord-328289-3h3kmjlz 198 29 of of IN cord-328289-3h3kmjlz 198 30 the the DT cord-328289-3h3kmjlz 198 31 frequency frequency NN cord-328289-3h3kmjlz 198 32 and and CC cord-328289-3h3kmjlz 198 33 type type NN cord-328289-3h3kmjlz 198 34 of of IN cord-328289-3h3kmjlz 198 35 the the DT cord-328289-3h3kmjlz 198 36 neurological neurological JJ cord-328289-3h3kmjlz 198 37 manifestations manifestation NNS cord-328289-3h3kmjlz 198 38 . . . cord-328289-3h3kmjlz 199 1 Similarly similarly RB cord-328289-3h3kmjlz 199 2 , , , cord-328289-3h3kmjlz 199 3 basic basic JJ cord-328289-3h3kmjlz 199 4 science science NN cord-328289-3h3kmjlz 199 5 investigations investigation NNS cord-328289-3h3kmjlz 199 6 exploring explore VBG cord-328289-3h3kmjlz 199 7 the the DT cord-328289-3h3kmjlz 199 8 mechanism mechanism NN cord-328289-3h3kmjlz 199 9 of of IN cord-328289-3h3kmjlz 199 10 disease disease NN cord-328289-3h3kmjlz 199 11 have have VBP cord-328289-3h3kmjlz 199 12 largely largely RB cord-328289-3h3kmjlz 199 13 emphasized emphasize VBN cord-328289-3h3kmjlz 199 14 concepts concept NNS cord-328289-3h3kmjlz 199 15 and and CC cord-328289-3h3kmjlz 199 16 findings finding NNS cord-328289-3h3kmjlz 199 17 that that WDT cord-328289-3h3kmjlz 199 18 emerged emerge VBD cord-328289-3h3kmjlz 199 19 from from IN cord-328289-3h3kmjlz 199 20 other other JJ cord-328289-3h3kmjlz 199 21 coronaviruses coronaviruse NNS cord-328289-3h3kmjlz 199 22 , , , cord-328289-3h3kmjlz 199 23 and and CC cord-328289-3h3kmjlz 199 24 there there EX cord-328289-3h3kmjlz 199 25 is be VBZ cord-328289-3h3kmjlz 199 26 limited limit VBN cord-328289-3h3kmjlz 199 27 new new JJ cord-328289-3h3kmjlz 199 28 data datum NNS cord-328289-3h3kmjlz 199 29 on on IN cord-328289-3h3kmjlz 199 30 the the DT cord-328289-3h3kmjlz 199 31 interaction interaction NN cord-328289-3h3kmjlz 199 32 of of IN cord-328289-3h3kmjlz 199 33 SARS SARS NNP cord-328289-3h3kmjlz 199 34 - - HYPH cord-328289-3h3kmjlz 199 35 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 199 36 with with IN cord-328289-3h3kmjlz 199 37 the the DT cord-328289-3h3kmjlz 199 38 brain brain NN cord-328289-3h3kmjlz 199 39 and and CC cord-328289-3h3kmjlz 199 40 its -PRON- PRP$ cord-328289-3h3kmjlz 199 41 vasculature vasculature NN cord-328289-3h3kmjlz 199 42 . . . cord-328289-3h3kmjlz 200 1 Therefore therefore RB cord-328289-3h3kmjlz 200 2 , , , cord-328289-3h3kmjlz 200 3 conclusions conclusion NNS cord-328289-3h3kmjlz 200 4 based base VBN cord-328289-3h3kmjlz 200 5 of of IN cord-328289-3h3kmjlz 200 6 existing exist VBG cord-328289-3h3kmjlz 200 7 literature literature NN cord-328289-3h3kmjlz 200 8 have have VBP cord-328289-3h3kmjlz 200 9 to to TO cord-328289-3h3kmjlz 200 10 be be VB cord-328289-3h3kmjlz 200 11 considered consider VBN cord-328289-3h3kmjlz 200 12 preliminary preliminary JJ cord-328289-3h3kmjlz 200 13 and and CC cord-328289-3h3kmjlz 200 14 subject subject JJ cord-328289-3h3kmjlz 200 15 to to IN cord-328289-3h3kmjlz 200 16 further further JJ cord-328289-3h3kmjlz 200 17 scrutiny scrutiny NN cord-328289-3h3kmjlz 200 18 , , , cord-328289-3h3kmjlz 200 19 verification verification NN cord-328289-3h3kmjlz 200 20 and and CC cord-328289-3h3kmjlz 200 21 validation validation NN cord-328289-3h3kmjlz 200 22 . . . cord-328289-3h3kmjlz 201 1 Here here RB cord-328289-3h3kmjlz 201 2 are be VBP cord-328289-3h3kmjlz 201 3 some some DT cord-328289-3h3kmjlz 201 4 of of IN cord-328289-3h3kmjlz 201 5 the the DT cord-328289-3h3kmjlz 201 6 outstanding outstanding JJ cord-328289-3h3kmjlz 201 7 questions question NNS cord-328289-3h3kmjlz 201 8 : : : cord-328289-3h3kmjlz 201 9 Do do VB cord-328289-3h3kmjlz 201 10 the the DT cord-328289-3h3kmjlz 201 11 neurological neurological JJ cord-328289-3h3kmjlz 201 12 manifestations manifestation NNS cord-328289-3h3kmjlz 201 13 of of IN cord-328289-3h3kmjlz 201 14 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 201 15 reflect reflect VBP cord-328289-3h3kmjlz 201 16 brain brain NN cord-328289-3h3kmjlz 201 17 invasion invasion NN cord-328289-3h3kmjlz 201 18 ? ? . cord-328289-3h3kmjlz 202 1 The the DT cord-328289-3h3kmjlz 202 2 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 202 3 is be VBZ cord-328289-3h3kmjlz 202 4 most most RBS cord-328289-3h3kmjlz 202 5 likely likely RB cord-328289-3h3kmjlz 202 6 a a DT cord-328289-3h3kmjlz 202 7 consequence consequence NN cord-328289-3h3kmjlz 202 8 of of IN cord-328289-3h3kmjlz 202 9 systemic systemic JJ cord-328289-3h3kmjlz 202 10 factors factor NNS cord-328289-3h3kmjlz 202 11 , , , cord-328289-3h3kmjlz 202 12 such such JJ cord-328289-3h3kmjlz 202 13 as as IN cord-328289-3h3kmjlz 202 14 cytokine cytokine JJ cord-328289-3h3kmjlz 202 15 sickness sickness NN cord-328289-3h3kmjlz 202 16 , , , cord-328289-3h3kmjlz 202 17 hypoxia hypoxia NN cord-328289-3h3kmjlz 202 18 and and CC cord-328289-3h3kmjlz 202 19 metabolic metabolic JJ cord-328289-3h3kmjlz 202 20 dysfunction dysfunction NN cord-328289-3h3kmjlz 202 21 due due IN cord-328289-3h3kmjlz 202 22 to to IN cord-328289-3h3kmjlz 202 23 peripheral peripheral JJ cord-328289-3h3kmjlz 202 24 organ organ NN cord-328289-3h3kmjlz 202 25 failure failure NN cord-328289-3h3kmjlz 202 26 , , , cord-328289-3h3kmjlz 202 27 while while IN cord-328289-3h3kmjlz 202 28 the the DT cord-328289-3h3kmjlz 202 29 strokes stroke NNS cord-328289-3h3kmjlz 202 30 seem seem VBP cord-328289-3h3kmjlz 202 31 to to TO cord-328289-3h3kmjlz 202 32 be be VB cord-328289-3h3kmjlz 202 33 related relate VBN cord-328289-3h3kmjlz 202 34 more more JJR cord-328289-3h3kmjlz 202 35 to to IN cord-328289-3h3kmjlz 202 36 hypercoagulability hypercoagulability NN cord-328289-3h3kmjlz 202 37 and and CC cord-328289-3h3kmjlz 202 38 endothelial endothelial JJ cord-328289-3h3kmjlz 202 39 injury injury NN cord-328289-3h3kmjlz 202 40 than than IN cord-328289-3h3kmjlz 202 41 to to IN cord-328289-3h3kmjlz 202 42 SARS SARS NNP cord-328289-3h3kmjlz 202 43 - - HYPH cord-328289-3h3kmjlz 202 44 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 202 45 vasculitis vasculitis NN cord-328289-3h3kmjlz 202 46 affecting affect VBG cord-328289-3h3kmjlz 202 47 brain brain NN cord-328289-3h3kmjlz 202 48 vessels vessel NNS cord-328289-3h3kmjlz 202 49 . . . cord-328289-3h3kmjlz 203 1 The the DT cord-328289-3h3kmjlz 203 2 loss loss NN cord-328289-3h3kmjlz 203 3 of of IN cord-328289-3h3kmjlz 203 4 taste taste NN cord-328289-3h3kmjlz 203 5 and and CC cord-328289-3h3kmjlz 203 6 smell smell NN cord-328289-3h3kmjlz 203 7 has have VBZ cord-328289-3h3kmjlz 203 8 been be VBN cord-328289-3h3kmjlz 203 9 attributed attribute VBN cord-328289-3h3kmjlz 203 10 to to IN cord-328289-3h3kmjlz 203 11 invasion invasion NN cord-328289-3h3kmjlz 203 12 of of IN cord-328289-3h3kmjlz 203 13 the the DT cord-328289-3h3kmjlz 203 14 olfactory olfactory JJ cord-328289-3h3kmjlz 203 15 neural neural JJ cord-328289-3h3kmjlz 203 16 system system NN cord-328289-3h3kmjlz 203 17 , , , cord-328289-3h3kmjlz 203 18 but but CC cord-328289-3h3kmjlz 203 19 consistent consistent JJ cord-328289-3h3kmjlz 203 20 evidence evidence NN cord-328289-3h3kmjlz 203 21 is be VBZ cord-328289-3h3kmjlz 203 22 lacking lack VBG cord-328289-3h3kmjlz 203 23 . . . cord-328289-3h3kmjlz 204 1 In in IN cord-328289-3h3kmjlz 204 2 some some DT cord-328289-3h3kmjlz 204 3 cases case NNS cord-328289-3h3kmjlz 204 4 , , , cord-328289-3h3kmjlz 204 5 the the DT cord-328289-3h3kmjlz 204 6 possibility possibility NN cord-328289-3h3kmjlz 204 7 of of IN cord-328289-3h3kmjlz 204 8 a a DT cord-328289-3h3kmjlz 204 9 SARS SARS NNP cord-328289-3h3kmjlz 204 10 - - HYPH cord-328289-3h3kmjlz 204 11 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 204 12 encephalitis encephalitis RB cord-328289-3h3kmjlz 204 13 could could MD cord-328289-3h3kmjlz 204 14 not not RB cord-328289-3h3kmjlz 204 15 be be VB cord-328289-3h3kmjlz 204 16 ruled rule VBN cord-328289-3h3kmjlz 204 17 out out RP cord-328289-3h3kmjlz 204 18 based base VBN cord-328289-3h3kmjlz 204 19 on on IN cord-328289-3h3kmjlz 204 20 the the DT cord-328289-3h3kmjlz 204 21 potential potential NN cord-328289-3h3kmjlz 204 22 for for IN cord-328289-3h3kmjlz 204 23 the the DT cord-328289-3h3kmjlz 204 24 virus virus NN cord-328289-3h3kmjlz 204 25 to to TO cord-328289-3h3kmjlz 204 26 infect infect VB cord-328289-3h3kmjlz 204 27 neurons neuron NNS cord-328289-3h3kmjlz 204 28 ( ( -LRB- cord-328289-3h3kmjlz 204 29 Song Song NNP cord-328289-3h3kmjlz 204 30 et et FW cord-328289-3h3kmjlz 204 31 al al NNP cord-328289-3h3kmjlz 204 32 . . NNP cord-328289-3h3kmjlz 204 33 , , , cord-328289-3h3kmjlz 204 34 2020 2020 CD cord-328289-3h3kmjlz 204 35 ) ) -RRB- cord-328289-3h3kmjlz 204 36 , , , cord-328289-3h3kmjlz 204 37 but but CC cord-328289-3h3kmjlz 204 38 definitive definitive JJ cord-328289-3h3kmjlz 204 39 clinical clinical JJ cord-328289-3h3kmjlz 204 40 and and CC cord-328289-3h3kmjlz 204 41 pathological pathological JJ cord-328289-3h3kmjlz 204 42 evidence evidence NN cord-328289-3h3kmjlz 204 43 of of IN cord-328289-3h3kmjlz 204 44 neurotropism neurotropism NN cord-328289-3h3kmjlz 204 45 is be VBZ cord-328289-3h3kmjlz 204 46 lacking lack VBG cord-328289-3h3kmjlz 204 47 . . . cord-328289-3h3kmjlz 205 1 A a DT cord-328289-3h3kmjlz 205 2 major major JJ cord-328289-3h3kmjlz 205 3 problem problem NN cord-328289-3h3kmjlz 205 4 is be VBZ cord-328289-3h3kmjlz 205 5 that that IN cord-328289-3h3kmjlz 205 6 the the DT cord-328289-3h3kmjlz 205 7 molecular molecular JJ cord-328289-3h3kmjlz 205 8 mechanisms mechanism NNS cord-328289-3h3kmjlz 205 9 of of IN cord-328289-3h3kmjlz 205 10 cellular cellular JJ cord-328289-3h3kmjlz 205 11 entry entry NN cord-328289-3h3kmjlz 205 12 for for IN cord-328289-3h3kmjlz 205 13 SARS SARS NNP cord-328289-3h3kmjlz 205 14 - - HYPH cord-328289-3h3kmjlz 205 15 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 205 16 are be VBP cord-328289-3h3kmjlz 205 17 not not RB cord-328289-3h3kmjlz 205 18 entirely entirely RB cord-328289-3h3kmjlz 205 19 clear clear JJ cord-328289-3h3kmjlz 205 20 . . . cord-328289-3h3kmjlz 206 1 While while IN cord-328289-3h3kmjlz 206 2 ACE2 ACE2 NNP cord-328289-3h3kmjlz 206 3 is be VBZ cord-328289-3h3kmjlz 206 4 thought think VBN cord-328289-3h3kmjlz 206 5 to to TO cord-328289-3h3kmjlz 206 6 be be VB cord-328289-3h3kmjlz 206 7 the the DT cord-328289-3h3kmjlz 206 8 main main JJ cord-328289-3h3kmjlz 206 9 receptors receptor NNS cord-328289-3h3kmjlz 206 10 in in IN cord-328289-3h3kmjlz 206 11 some some DT cord-328289-3h3kmjlz 206 12 cell cell NN cord-328289-3h3kmjlz 206 13 types type NNS cord-328289-3h3kmjlz 206 14 , , , cord-328289-3h3kmjlz 206 15 its -PRON- PRP$ cord-328289-3h3kmjlz 206 16 expression expression NN cord-328289-3h3kmjlz 206 17 levels level NNS cord-328289-3h3kmjlz 206 18 do do VBP cord-328289-3h3kmjlz 206 19 not not RB cord-328289-3h3kmjlz 206 20 seem seem VB cord-328289-3h3kmjlz 206 21 to to TO cord-328289-3h3kmjlz 206 22 correlate correlate VB cord-328289-3h3kmjlz 206 23 with with IN cord-328289-3h3kmjlz 206 24 the the DT cord-328289-3h3kmjlz 206 25 infectivity infectivity NN cord-328289-3h3kmjlz 206 26 potential potential NN cord-328289-3h3kmjlz 206 27 . . . cord-328289-3h3kmjlz 207 1 For for IN cord-328289-3h3kmjlz 207 2 example example NN cord-328289-3h3kmjlz 207 3 , , , cord-328289-3h3kmjlz 207 4 the the DT cord-328289-3h3kmjlz 207 5 virus virus NN cord-328289-3h3kmjlz 207 6 gains gain VBZ cord-328289-3h3kmjlz 207 7 access access NN cord-328289-3h3kmjlz 207 8 to to IN cord-328289-3h3kmjlz 207 9 human human JJ cord-328289-3h3kmjlz 207 10 pluripotent pluripotent JJ cord-328289-3h3kmjlz 207 11 stem stem NN cord-328289-3h3kmjlz 207 12 cell cell NN cord-328289-3h3kmjlz 207 13 - - HYPH cord-328289-3h3kmjlz 207 14 derived derive VBN cord-328289-3h3kmjlz 207 15 dopaminergic dopaminergic JJ cord-328289-3h3kmjlz 207 16 neurons neuron NNS cord-328289-3h3kmjlz 207 17 despite despite IN cord-328289-3h3kmjlz 207 18 low low JJ cord-328289-3h3kmjlz 207 19 levels level NNS cord-328289-3h3kmjlz 207 20 of of IN cord-328289-3h3kmjlz 207 21 ACE2 ACE2 NNP cord-328289-3h3kmjlz 207 22 . . . cord-328289-3h3kmjlz 208 1 Systematic systematic JJ cord-328289-3h3kmjlz 208 2 investigation investigation NN cord-328289-3h3kmjlz 208 3 of of IN cord-328289-3h3kmjlz 208 4 non non JJ cord-328289-3h3kmjlz 208 5 - - JJ cord-328289-3h3kmjlz 208 6 canonical canonical JJ cord-328289-3h3kmjlz 208 7 docking docking NN cord-328289-3h3kmjlz 208 8 and and CC cord-328289-3h3kmjlz 208 9 accessory accessory NN cord-328289-3h3kmjlz 208 10 proteins protein NNS cord-328289-3h3kmjlz 208 11 for for IN cord-328289-3h3kmjlz 208 12 SARS SARS NNP cord-328289-3h3kmjlz 208 13 - - HYPH cord-328289-3h3kmjlz 208 14 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 208 15 ( ( -LRB- cord-328289-3h3kmjlz 208 16 Figures figure NNS cord-328289-3h3kmjlz 208 17 1 1 CD cord-328289-3h3kmjlz 208 18 , , , cord-328289-3h3kmjlz 208 19 S1 S1 NNP cord-328289-3h3kmjlz 208 20 ) ) -RRB- cord-328289-3h3kmjlz 208 21 , , , cord-328289-3h3kmjlz 208 22 their -PRON- PRP$ cord-328289-3h3kmjlz 208 23 cellular cellular JJ cord-328289-3h3kmjlz 208 24 localization localization NN cord-328289-3h3kmjlz 208 25 and and CC cord-328289-3h3kmjlz 208 26 function function NN cord-328289-3h3kmjlz 208 27 in in IN cord-328289-3h3kmjlz 208 28 human human JJ cord-328289-3h3kmjlz 208 29 neurons neuron NNS cord-328289-3h3kmjlz 208 30 , , , cord-328289-3h3kmjlz 208 31 glia glia NN cord-328289-3h3kmjlz 208 32 and and CC cord-328289-3h3kmjlz 208 33 vascular vascular JJ cord-328289-3h3kmjlz 208 34 cells cell NNS cord-328289-3h3kmjlz 208 35 would would MD cord-328289-3h3kmjlz 208 36 help help VB cord-328289-3h3kmjlz 208 37 address address VB cord-328289-3h3kmjlz 208 38 this this DT cord-328289-3h3kmjlz 208 39 question question NN cord-328289-3h3kmjlz 208 40 . . . cord-328289-3h3kmjlz 209 1 Does do VBZ cord-328289-3h3kmjlz 209 2 the the DT cord-328289-3h3kmjlz 209 3 brain brain NN cord-328289-3h3kmjlz 209 4 contribute contribute VB cord-328289-3h3kmjlz 209 5 to to IN cord-328289-3h3kmjlz 209 6 the the DT cord-328289-3h3kmjlz 209 7 immune immune JJ cord-328289-3h3kmjlz 209 8 dysregulation dysregulation NN cord-328289-3h3kmjlz 209 9 ? ? . cord-328289-3h3kmjlz 210 1 SARS SARS NNP cord-328289-3h3kmjlz 210 2 - - HYPH cord-328289-3h3kmjlz 210 3 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 210 4 and and CC cord-328289-3h3kmjlz 210 5 inflammatory inflammatory JJ cord-328289-3h3kmjlz 210 6 mediators mediator NNS cord-328289-3h3kmjlz 210 7 may may MD cord-328289-3h3kmjlz 210 8 gain gain VB cord-328289-3h3kmjlz 210 9 access access NN cord-328289-3h3kmjlz 210 10 to to IN cord-328289-3h3kmjlz 210 11 the the DT cord-328289-3h3kmjlz 210 12 median median JJ cord-328289-3h3kmjlz 210 13 eminence eminence NN cord-328289-3h3kmjlz 210 14 and and CC cord-328289-3h3kmjlz 210 15 activate activate VBP cord-328289-3h3kmjlz 210 16 hypothalamic hypothalamic JJ cord-328289-3h3kmjlz 210 17 neurohumoral neurohumoral JJ cord-328289-3h3kmjlz 210 18 pathways pathway NNS cord-328289-3h3kmjlz 210 19 that that WDT cord-328289-3h3kmjlz 210 20 mediate mediate VBP cord-328289-3h3kmjlz 210 21 immune immune JJ cord-328289-3h3kmjlz 210 22 dysregulation dysregulation NN cord-328289-3h3kmjlz 210 23 through through IN cord-328289-3h3kmjlz 210 24 the the DT cord-328289-3h3kmjlz 210 25 adrenergic adrenergic NN cord-328289-3h3kmjlz 210 26 system system NN cord-328289-3h3kmjlz 210 27 , , , cord-328289-3h3kmjlz 210 28 as as IN cord-328289-3h3kmjlz 210 29 described describe VBN cord-328289-3h3kmjlz 210 30 in in IN cord-328289-3h3kmjlz 210 31 other other JJ cord-328289-3h3kmjlz 210 32 brain brain NN cord-328289-3h3kmjlz 210 33 diseases disease NNS cord-328289-3h3kmjlz 210 34 ( ( -LRB- cord-328289-3h3kmjlz 210 35 Figure figure NN cord-328289-3h3kmjlz 210 36 3 3 CD cord-328289-3h3kmjlz 210 37 ) ) -RRB- cord-328289-3h3kmjlz 210 38 . . . cord-328289-3h3kmjlz 211 1 Considering consider VBG cord-328289-3h3kmjlz 211 2 the the DT cord-328289-3h3kmjlz 211 3 importance importance NN cord-328289-3h3kmjlz 211 4 of of IN cord-328289-3h3kmjlz 211 5 the the DT cord-328289-3h3kmjlz 211 6 immune immune JJ cord-328289-3h3kmjlz 211 7 dysregulation dysregulation NN cord-328289-3h3kmjlz 211 8 in in IN cord-328289-3h3kmjlz 211 9 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 211 10 severity severity NN cord-328289-3h3kmjlz 211 11 and and CC cord-328289-3h3kmjlz 211 12 outcome outcome NN cord-328289-3h3kmjlz 211 13 , , , cord-328289-3h3kmjlz 211 14 a a DT cord-328289-3h3kmjlz 211 15 better well JJR cord-328289-3h3kmjlz 211 16 understanding understanding NN cord-328289-3h3kmjlz 211 17 of of IN cord-328289-3h3kmjlz 211 18 the the DT cord-328289-3h3kmjlz 211 19 contribution contribution NN cord-328289-3h3kmjlz 211 20 of of IN cord-328289-3h3kmjlz 211 21 the the DT cord-328289-3h3kmjlz 211 22 hypothalamus hypothalamus NN cord-328289-3h3kmjlz 211 23 may may MD cord-328289-3h3kmjlz 211 24 suggest suggest VB cord-328289-3h3kmjlz 211 25 pharmacological pharmacological JJ cord-328289-3h3kmjlz 211 26 approaches approach NNS cord-328289-3h3kmjlz 211 27 to to TO cord-328289-3h3kmjlz 211 28 dampen dampen VB cord-328289-3h3kmjlz 211 29 the the DT cord-328289-3h3kmjlz 211 30 immune immune JJ cord-328289-3h3kmjlz 211 31 dysregulation dysregulation NN cord-328289-3h3kmjlz 211 32 . . . cord-328289-3h3kmjlz 212 1 Does do VBZ cord-328289-3h3kmjlz 212 2 the the DT cord-328289-3h3kmjlz 212 3 brain brain NN cord-328289-3h3kmjlz 212 4 contribute contribute VB cord-328289-3h3kmjlz 212 5 to to IN cord-328289-3h3kmjlz 212 6 respiratory respiratory JJ cord-328289-3h3kmjlz 212 7 failure failure NN cord-328289-3h3kmjlz 212 8 and and CC cord-328289-3h3kmjlz 212 9 hypertension hypertension NN cord-328289-3h3kmjlz 212 10 ? ? . cord-328289-3h3kmjlz 213 1 Similarly similarly RB cord-328289-3h3kmjlz 213 2 , , , cord-328289-3h3kmjlz 213 3 entry entry NN cord-328289-3h3kmjlz 213 4 of of IN cord-328289-3h3kmjlz 213 5 the the DT cord-328289-3h3kmjlz 213 6 virus virus NN cord-328289-3h3kmjlz 213 7 and/or and/or CC cord-328289-3h3kmjlz 213 8 proinflammatory proinflammatory JJ cord-328289-3h3kmjlz 213 9 molecules molecule NNS cord-328289-3h3kmjlz 213 10 through through IN cord-328289-3h3kmjlz 213 11 the the DT cord-328289-3h3kmjlz 213 12 subfornical subfornical JJ cord-328289-3h3kmjlz 213 13 organ organ NN cord-328289-3h3kmjlz 213 14 and and CC cord-328289-3h3kmjlz 213 15 the the DT cord-328289-3h3kmjlz 213 16 area area NN cord-328289-3h3kmjlz 213 17 postrema postrema NNP cord-328289-3h3kmjlz 213 18 could could MD cord-328289-3h3kmjlz 213 19 also also RB cord-328289-3h3kmjlz 213 20 affect affect VB cord-328289-3h3kmjlz 213 21 brainstem brainstem NNP cord-328289-3h3kmjlz 213 22 autonomic autonomic JJ cord-328289-3h3kmjlz 213 23 pathways pathway NNS cord-328289-3h3kmjlz 213 24 controlling control VBG cord-328289-3h3kmjlz 213 25 blood blood NN cord-328289-3h3kmjlz 213 26 pressure pressure NN cord-328289-3h3kmjlz 213 27 and and CC cord-328289-3h3kmjlz 213 28 breathing breathing NN cord-328289-3h3kmjlz 213 29 ( ( -LRB- cord-328289-3h3kmjlz 213 30 Kaur Kaur NNP cord-328289-3h3kmjlz 213 31 and and CC cord-328289-3h3kmjlz 213 32 Ling Ling NNP cord-328289-3h3kmjlz 213 33 , , , cord-328289-3h3kmjlz 213 34 2017 2017 CD cord-328289-3h3kmjlz 213 35 ) ) -RRB- cord-328289-3h3kmjlz 213 36 . . . cord-328289-3h3kmjlz 214 1 Alterations alteration NNS cord-328289-3h3kmjlz 214 2 in in IN cord-328289-3h3kmjlz 214 3 blood blood NN cord-328289-3h3kmjlz 214 4 pressure pressure NN cord-328289-3h3kmjlz 214 5 , , , cord-328289-3h3kmjlz 214 6 both both CC cord-328289-3h3kmjlz 214 7 hypertension hypertension NN cord-328289-3h3kmjlz 214 8 and and CC cord-328289-3h3kmjlz 214 9 severe severe JJ cord-328289-3h3kmjlz 214 10 hypotension hypotension NN cord-328289-3h3kmjlz 214 11 in in IN cord-328289-3h3kmjlz 214 12 critically critically RB cord-328289-3h3kmjlz 214 13 patients patient NNS cord-328289-3h3kmjlz 214 14 , , , cord-328289-3h3kmjlz 214 15 are be VBP cord-328289-3h3kmjlz 214 16 highly highly RB cord-328289-3h3kmjlz 214 17 prevalent prevalent JJ cord-328289-3h3kmjlz 214 18 in in IN cord-328289-3h3kmjlz 214 19 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 214 20 . . . cord-328289-3h3kmjlz 215 1 Furthermore furthermore RB cord-328289-3h3kmjlz 215 2 , , , cord-328289-3h3kmjlz 215 3 it -PRON- PRP cord-328289-3h3kmjlz 215 4 has have VBZ cord-328289-3h3kmjlz 215 5 been be VBN cord-328289-3h3kmjlz 215 6 suggested suggest VBN cord-328289-3h3kmjlz 215 7 that that IN cord-328289-3h3kmjlz 215 8 involvement involvement NN cord-328289-3h3kmjlz 215 9 of of IN cord-328289-3h3kmjlz 215 10 brainstem brainstem NN cord-328289-3h3kmjlz 215 11 respiratory respiratory JJ cord-328289-3h3kmjlz 215 12 nuclei nucleus NNS cord-328289-3h3kmjlz 215 13 may may MD cord-328289-3h3kmjlz 215 14 contribute contribute VB cord-328289-3h3kmjlz 215 15 to to IN cord-328289-3h3kmjlz 215 16 the the DT cord-328289-3h3kmjlz 215 17 respiratory respiratory JJ cord-328289-3h3kmjlz 215 18 failure failure NN cord-328289-3h3kmjlz 215 19 , , , cord-328289-3h3kmjlz 215 20 but but CC cord-328289-3h3kmjlz 215 21 no no DT cord-328289-3h3kmjlz 215 22 alterations alteration NNS cord-328289-3h3kmjlz 215 23 in in IN cord-328289-3h3kmjlz 215 24 respiratory respiratory JJ cord-328289-3h3kmjlz 215 25 centers center NNS cord-328289-3h3kmjlz 215 26 or or CC cord-328289-3h3kmjlz 215 27 chemoreceptors chemoreceptor NNS cord-328289-3h3kmjlz 215 28 ( ( -LRB- cord-328289-3h3kmjlz 215 29 carotid carotid JJ cord-328289-3h3kmjlz 215 30 bodies body NNS cord-328289-3h3kmjlz 215 31 ) ) -RRB- cord-328289-3h3kmjlz 215 32 was be VBD cord-328289-3h3kmjlz 215 33 observed observe VBN cord-328289-3h3kmjlz 215 34 at at IN cord-328289-3h3kmjlz 215 35 autopsy autopsy NN cord-328289-3h3kmjlz 215 36 in in IN cord-328289-3h3kmjlz 215 37 a a DT cord-328289-3h3kmjlz 215 38 patient patient NN cord-328289-3h3kmjlz 215 39 with with IN cord-328289-3h3kmjlz 215 40 respiratory respiratory JJ cord-328289-3h3kmjlz 215 41 dysregulation dysregulation NN cord-328289-3h3kmjlz 215 42 ( ( -LRB- cord-328289-3h3kmjlz 215 43 Kantonen Kantonen NNP cord-328289-3h3kmjlz 215 44 et et FW cord-328289-3h3kmjlz 215 45 al al NNP cord-328289-3h3kmjlz 215 46 . . NNP cord-328289-3h3kmjlz 215 47 , , , cord-328289-3h3kmjlz 215 48 2020 2020 CD cord-328289-3h3kmjlz 215 49 ) ) -RRB- cord-328289-3h3kmjlz 215 50 . . . cord-328289-3h3kmjlz 216 1 To to IN cord-328289-3h3kmjlz 216 2 date date NN cord-328289-3h3kmjlz 216 3 , , , cord-328289-3h3kmjlz 216 4 evidence evidence NN cord-328289-3h3kmjlz 216 5 of of IN cord-328289-3h3kmjlz 216 6 central central JJ cord-328289-3h3kmjlz 216 7 autonomic autonomic JJ cord-328289-3h3kmjlz 216 8 involvement involvement NN cord-328289-3h3kmjlz 216 9 is be VBZ cord-328289-3h3kmjlz 216 10 lacking lack VBG cord-328289-3h3kmjlz 216 11 . . . cord-328289-3h3kmjlz 217 1 What what WP cord-328289-3h3kmjlz 217 2 are be VBP cord-328289-3h3kmjlz 217 3 the the DT cord-328289-3h3kmjlz 217 4 long long JJ cord-328289-3h3kmjlz 217 5 - - HYPH cord-328289-3h3kmjlz 217 6 term term NN cord-328289-3h3kmjlz 217 7 neurological neurological JJ cord-328289-3h3kmjlz 217 8 and and CC cord-328289-3h3kmjlz 217 9 neuropsychiatric neuropsychiatric JJ cord-328289-3h3kmjlz 217 10 consequences consequence NNS cord-328289-3h3kmjlz 217 11 of of IN cord-328289-3h3kmjlz 217 12 COVID-19 covid-19 NN cord-328289-3h3kmjlz 217 13 ? ? . cord-328289-3h3kmjlz 218 1 Respiratory respiratory JJ cord-328289-3h3kmjlz 218 2 virus virus NN cord-328289-3h3kmjlz 218 3 infections infection NNS cord-328289-3h3kmjlz 218 4 are be VBP cord-328289-3h3kmjlz 218 5 associated associate VBN cord-328289-3h3kmjlz 218 6 with with IN cord-328289-3h3kmjlz 218 7 neurological neurological JJ cord-328289-3h3kmjlz 218 8 and and CC cord-328289-3h3kmjlz 218 9 psychiatric psychiatric JJ cord-328289-3h3kmjlz 218 10 sequelae sequela NNS cord-328289-3h3kmjlz 218 11 , , , cord-328289-3h3kmjlz 218 12 including include VBG cord-328289-3h3kmjlz 218 13 Parkinsonism parkinsonism NN cord-328289-3h3kmjlz 218 14 , , , cord-328289-3h3kmjlz 218 15 dementia dementia NN cord-328289-3h3kmjlz 218 16 , , , cord-328289-3h3kmjlz 218 17 depression depression NN cord-328289-3h3kmjlz 218 18 , , , cord-328289-3h3kmjlz 218 19 post post JJ cord-328289-3h3kmjlz 218 20 - - JJ cord-328289-3h3kmjlz 218 21 traumatic traumatic JJ cord-328289-3h3kmjlz 218 22 stress stress NN cord-328289-3h3kmjlz 218 23 disorder disorder NN cord-328289-3h3kmjlz 218 24 and and CC cord-328289-3h3kmjlz 218 25 anxiety anxiety NN cord-328289-3h3kmjlz 218 26 ( ( -LRB- cord-328289-3h3kmjlz 218 27 Limphaibool Limphaibool NNP cord-328289-3h3kmjlz 218 28 et et NNP cord-328289-3h3kmjlz 218 29 al al NNP cord-328289-3h3kmjlz 218 30 . . NNP cord-328289-3h3kmjlz 218 31 , , , cord-328289-3h3kmjlz 218 32 2019 2019 CD cord-328289-3h3kmjlz 218 33 ; ; : cord-328289-3h3kmjlz 218 34 Rogers Rogers NNP cord-328289-3h3kmjlz 218 35 et et NNP cord-328289-3h3kmjlz 218 36 al al NNP cord-328289-3h3kmjlz 218 37 . . NNP cord-328289-3h3kmjlz 218 38 , , , cord-328289-3h3kmjlz 218 39 2020 2020 CD cord-328289-3h3kmjlz 218 40 ) ) -RRB- cord-328289-3h3kmjlz 218 41 . . . cord-328289-3h3kmjlz 219 1 Brain brain NN cord-328289-3h3kmjlz 219 2 infection infection NN cord-328289-3h3kmjlz 219 3 is be VBZ cord-328289-3h3kmjlz 219 4 not not RB cord-328289-3h3kmjlz 219 5 required require VBN cord-328289-3h3kmjlz 219 6 for for IN cord-328289-3h3kmjlz 219 7 these these DT cord-328289-3h3kmjlz 219 8 long long JJ cord-328289-3h3kmjlz 219 9 - - HYPH cord-328289-3h3kmjlz 219 10 term term NN cord-328289-3h3kmjlz 219 11 effects effect NNS cord-328289-3h3kmjlz 219 12 . . . cord-328289-3h3kmjlz 220 1 Inflammation inflammation NN cord-328289-3h3kmjlz 220 2 and and CC cord-328289-3h3kmjlz 220 3 cytokine cytokine NN cord-328289-3h3kmjlz 220 4 elevation elevation NN cord-328289-3h3kmjlz 220 5 in in IN cord-328289-3h3kmjlz 220 6 sepsis sepsis NN cord-328289-3h3kmjlz 220 7 survivors survivor NNS cord-328289-3h3kmjlz 220 8 are be VBP cord-328289-3h3kmjlz 220 9 linked link VBN cord-328289-3h3kmjlz 220 10 to to IN cord-328289-3h3kmjlz 220 11 subsequent subsequent JJ cord-328289-3h3kmjlz 220 12 hippocampal hippocampal JJ cord-328289-3h3kmjlz 220 13 atrophy atrophy NN cord-328289-3h3kmjlz 220 14 and and CC cord-328289-3h3kmjlz 220 15 cognitive cognitive JJ cord-328289-3h3kmjlz 220 16 impairment impairment NN cord-328289-3h3kmjlz 221 1 ( ( -LRB- cord-328289-3h3kmjlz 221 2 Iwashyna Iwashyna NNP cord-328289-3h3kmjlz 221 3 et et NNP cord-328289-3h3kmjlz 221 4 al al NNP cord-328289-3h3kmjlz 221 5 . . NNP cord-328289-3h3kmjlz 221 6 , , , cord-328289-3h3kmjlz 221 7 2010 2010 CD cord-328289-3h3kmjlz 221 8 ) ) -RRB- cord-328289-3h3kmjlz 221 9 . . . cord-328289-3h3kmjlz 222 1 Experimental experimental JJ cord-328289-3h3kmjlz 222 2 studies study NNS cord-328289-3h3kmjlz 222 3 suggest suggest VBP cord-328289-3h3kmjlz 222 4 a a DT cord-328289-3h3kmjlz 222 5 link link NN cord-328289-3h3kmjlz 222 6 between between IN cord-328289-3h3kmjlz 222 7 activation activation NN cord-328289-3h3kmjlz 222 8 of of IN cord-328289-3h3kmjlz 222 9 the the DT cord-328289-3h3kmjlz 222 10 NLRP3 NLRP3 NNP cord-328289-3h3kmjlz 222 11 inflammasome inflammasome NNP cord-328289-3h3kmjlz 222 12 , , , cord-328289-3h3kmjlz 222 13 which which WDT cord-328289-3h3kmjlz 222 14 may may MD cord-328289-3h3kmjlz 222 15 occur occur VB cord-328289-3h3kmjlz 222 16 in in IN cord-328289-3h3kmjlz 222 17 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 222 18 , , , cord-328289-3h3kmjlz 222 19 and and CC cord-328289-3h3kmjlz 222 20 Alzheimer Alzheimer NNP cord-328289-3h3kmjlz 222 21 J J NNP cord-328289-3h3kmjlz 222 22 o o NN cord-328289-3h3kmjlz 222 23 u u NN cord-328289-3h3kmjlz 222 24 r r NN cord-328289-3h3kmjlz 222 25 n n NN cord-328289-3h3kmjlz 222 26 a a DT cord-328289-3h3kmjlz 222 27 l l NN cord-328289-3h3kmjlz 222 28 P p NN cord-328289-3h3kmjlz 222 29 r r NN cord-328289-3h3kmjlz 222 30 e e NN cord-328289-3h3kmjlz 222 31 -p -p NN cord-328289-3h3kmjlz 222 32 r r NN cord-328289-3h3kmjlz 222 33 o o NN cord-328289-3h3kmjlz 223 1 o o UH cord-328289-3h3kmjlz 223 2 f f NN cord-328289-3h3kmjlz 223 3 pathology pathology NN cord-328289-3h3kmjlz 224 1 ( ( -LRB- cord-328289-3h3kmjlz 224 2 Ising Ising NNP cord-328289-3h3kmjlz 224 3 et et NNP cord-328289-3h3kmjlz 224 4 al al NNP cord-328289-3h3kmjlz 224 5 . . NNP cord-328289-3h3kmjlz 224 6 , , , cord-328289-3h3kmjlz 224 7 2019 2019 CD cord-328289-3h3kmjlz 224 8 ) ) -RRB- cord-328289-3h3kmjlz 224 9 . . . cord-328289-3h3kmjlz 225 1 ARDS ARDS NNP cord-328289-3h3kmjlz 225 2 survivors survivor NNS cord-328289-3h3kmjlz 225 3 also also RB cord-328289-3h3kmjlz 225 4 exhibit exhibit VBP cord-328289-3h3kmjlz 225 5 increased increase VBN cord-328289-3h3kmjlz 225 6 incidence incidence NN cord-328289-3h3kmjlz 225 7 of of IN cord-328289-3h3kmjlz 225 8 long long JJ cord-328289-3h3kmjlz 225 9 - - HYPH cord-328289-3h3kmjlz 225 10 term term NN cord-328289-3h3kmjlz 225 11 depression depression NN cord-328289-3h3kmjlz 225 12 , , , cord-328289-3h3kmjlz 225 13 anxiety anxiety NN cord-328289-3h3kmjlz 225 14 and and CC cord-328289-3h3kmjlz 225 15 cognitive cognitive JJ cord-328289-3h3kmjlz 225 16 impairment impairment NN cord-328289-3h3kmjlz 225 17 ( ( -LRB- cord-328289-3h3kmjlz 225 18 Hopkins Hopkins NNP cord-328289-3h3kmjlz 225 19 et et NNP cord-328289-3h3kmjlz 225 20 al al NNP cord-328289-3h3kmjlz 225 21 . . NNP cord-328289-3h3kmjlz 225 22 , , , cord-328289-3h3kmjlz 225 23 2005 2005 CD cord-328289-3h3kmjlz 225 24 ) ) -RRB- cord-328289-3h3kmjlz 225 25 . . . cord-328289-3h3kmjlz 226 1 Whether whether IN cord-328289-3h3kmjlz 226 2 these these DT cord-328289-3h3kmjlz 226 3 late late JJ cord-328289-3h3kmjlz 226 4 manifestations manifestation NNS cord-328289-3h3kmjlz 226 5 are be VBP cord-328289-3h3kmjlz 226 6 related relate VBN cord-328289-3h3kmjlz 226 7 to to IN cord-328289-3h3kmjlz 226 8 non non JJ cord-328289-3h3kmjlz 226 9 - - JJ cord-328289-3h3kmjlz 226 10 resolving resolve VBG cord-328289-3h3kmjlz 226 11 inflammation inflammation NN cord-328289-3h3kmjlz 226 12 or or CC cord-328289-3h3kmjlz 226 13 a a DT cord-328289-3h3kmjlz 226 14 low low JJ cord-328289-3h3kmjlz 226 15 - - HYPH cord-328289-3h3kmjlz 226 16 grade grade NN cord-328289-3h3kmjlz 226 17 immune immune JJ cord-328289-3h3kmjlz 226 18 process process NN cord-328289-3h3kmjlz 226 19 driven drive VBN cord-328289-3h3kmjlz 226 20 by by IN cord-328289-3h3kmjlz 226 21 molecular molecular JJ cord-328289-3h3kmjlz 226 22 mimicry mimicry NN cord-328289-3h3kmjlz 226 23 or or CC cord-328289-3h3kmjlz 226 24 dysregulated dysregulate VBN cord-328289-3h3kmjlz 226 25 adaptive adaptive JJ cord-328289-3h3kmjlz 226 26 immunity immunity NN cord-328289-3h3kmjlz 226 27 remains remain VBZ cord-328289-3h3kmjlz 226 28 to to TO cord-328289-3h3kmjlz 226 29 be be VB cord-328289-3h3kmjlz 226 30 established establish VBN cord-328289-3h3kmjlz 226 31 . . . cord-328289-3h3kmjlz 227 1 Chronic chronic JJ cord-328289-3h3kmjlz 227 2 damage damage NN cord-328289-3h3kmjlz 227 3 to to IN cord-328289-3h3kmjlz 227 4 systemic systemic JJ cord-328289-3h3kmjlz 227 5 organs organ NNS cord-328289-3h3kmjlz 227 6 can can MD cord-328289-3h3kmjlz 227 7 also also RB cord-328289-3h3kmjlz 227 8 harm harm VB cord-328289-3h3kmjlz 227 9 the the DT cord-328289-3h3kmjlz 227 10 brain brain NN cord-328289-3h3kmjlz 227 11 through through IN cord-328289-3h3kmjlz 227 12 chronic chronic JJ cord-328289-3h3kmjlz 227 13 hypoxia hypoxia NN cord-328289-3h3kmjlz 227 14 , , , cord-328289-3h3kmjlz 227 15 metabolic metabolic JJ cord-328289-3h3kmjlz 227 16 dysfunction dysfunction NN cord-328289-3h3kmjlz 227 17 and and CC cord-328289-3h3kmjlz 227 18 hormonal hormonal JJ cord-328289-3h3kmjlz 227 19 dysregulation dysregulation NN cord-328289-3h3kmjlz 227 20 . . . cord-328289-3h3kmjlz 228 1 Based base VBN cord-328289-3h3kmjlz 228 2 on on IN cord-328289-3h3kmjlz 228 3 these these DT cord-328289-3h3kmjlz 228 4 considerations consideration NNS cord-328289-3h3kmjlz 228 5 , , , cord-328289-3h3kmjlz 228 6 significant significant JJ cord-328289-3h3kmjlz 228 7 long long JJ cord-328289-3h3kmjlz 228 8 - - HYPH cord-328289-3h3kmjlz 228 9 term term NN cord-328289-3h3kmjlz 228 10 neurological neurological JJ cord-328289-3h3kmjlz 228 11 and and CC cord-328289-3h3kmjlz 228 12 psychiatric psychiatric JJ cord-328289-3h3kmjlz 228 13 sequelae sequela NNS cord-328289-3h3kmjlz 228 14 have have VBP cord-328289-3h3kmjlz 228 15 to to TO cord-328289-3h3kmjlz 228 16 be be VB cord-328289-3h3kmjlz 228 17 anticipated anticipate VBN cord-328289-3h3kmjlz 228 18 in in IN cord-328289-3h3kmjlz 228 19 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 228 20 , , , cord-328289-3h3kmjlz 228 21 especially especially RB cord-328289-3h3kmjlz 228 22 in in IN cord-328289-3h3kmjlz 228 23 survivors survivor NNS cord-328289-3h3kmjlz 228 24 of of IN cord-328289-3h3kmjlz 228 25 severe severe JJ cord-328289-3h3kmjlz 228 26 disease disease NN cord-328289-3h3kmjlz 228 27 . . . cord-328289-3h3kmjlz 229 1 Experimental experimental JJ cord-328289-3h3kmjlz 229 2 models model NNS cord-328289-3h3kmjlz 230 1 : : : cord-328289-3h3kmjlz 230 2 Models model NNS cord-328289-3h3kmjlz 230 3 would would MD cord-328289-3h3kmjlz 230 4 help help VB cord-328289-3h3kmjlz 230 5 address address VB cord-328289-3h3kmjlz 230 6 these these DT cord-328289-3h3kmjlz 230 7 outstanding outstanding JJ cord-328289-3h3kmjlz 230 8 questions question NNS cord-328289-3h3kmjlz 230 9 and and CC cord-328289-3h3kmjlz 230 10 facilitate facilitate VB cord-328289-3h3kmjlz 230 11 therapeutic therapeutic JJ cord-328289-3h3kmjlz 230 12 development development NN cord-328289-3h3kmjlz 230 13 . . . cord-328289-3h3kmjlz 231 1 Unfortunately unfortunately RB cord-328289-3h3kmjlz 231 2 , , , cord-328289-3h3kmjlz 231 3 mice mouse NNS cord-328289-3h3kmjlz 231 4 , , , cord-328289-3h3kmjlz 231 5 the the DT cord-328289-3h3kmjlz 231 6 most most RBS cord-328289-3h3kmjlz 231 7 popular popular JJ cord-328289-3h3kmjlz 231 8 laboratory laboratory NN cord-328289-3h3kmjlz 231 9 animals animal NNS cord-328289-3h3kmjlz 231 10 , , , cord-328289-3h3kmjlz 231 11 are be VBP cord-328289-3h3kmjlz 231 12 not not RB cord-328289-3h3kmjlz 231 13 susceptible susceptible JJ cord-328289-3h3kmjlz 231 14 to to IN cord-328289-3h3kmjlz 231 15 SARS SARS NNP cord-328289-3h3kmjlz 231 16 - - HYPH cord-328289-3h3kmjlz 231 17 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 231 18 due due JJ cord-328289-3h3kmjlz 231 19 to to IN cord-328289-3h3kmjlz 231 20 differences difference NNS cord-328289-3h3kmjlz 231 21 between between IN cord-328289-3h3kmjlz 231 22 mouse mouse NN cord-328289-3h3kmjlz 231 23 and and CC cord-328289-3h3kmjlz 231 24 human human JJ cord-328289-3h3kmjlz 231 25 ACE2 ACE2 NNP cord-328289-3h3kmjlz 231 26 ( ( -LRB- cord-328289-3h3kmjlz 231 27 Lakdawala Lakdawala NNP cord-328289-3h3kmjlz 231 28 and and CC cord-328289-3h3kmjlz 231 29 Menachery Menachery NNP cord-328289-3h3kmjlz 231 30 , , , cord-328289-3h3kmjlz 231 31 2020 2020 CD cord-328289-3h3kmjlz 231 32 ) ) -RRB- cord-328289-3h3kmjlz 231 33 . . . cord-328289-3h3kmjlz 232 1 Mice mouse NNS cord-328289-3h3kmjlz 232 2 expressing express VBG cord-328289-3h3kmjlz 232 3 human human JJ cord-328289-3h3kmjlz 232 4 ACE2 ACE2 NNP cord-328289-3h3kmjlz 232 5 have have VBP cord-328289-3h3kmjlz 232 6 been be VBN cord-328289-3h3kmjlz 232 7 developed develop VBN cord-328289-3h3kmjlz 232 8 and and CC cord-328289-3h3kmjlz 232 9 show show VB cord-328289-3h3kmjlz 232 10 evidence evidence NN cord-328289-3h3kmjlz 232 11 of of IN cord-328289-3h3kmjlz 232 12 brain brain NN cord-328289-3h3kmjlz 232 13 infection infection NN cord-328289-3h3kmjlz 232 14 , , , cord-328289-3h3kmjlz 232 15 but but CC cord-328289-3h3kmjlz 232 16 only only RB cord-328289-3h3kmjlz 232 17 minimal minimal JJ cord-328289-3h3kmjlz 232 18 symptoms symptom NNS cord-328289-3h3kmjlz 232 19 of of IN cord-328289-3h3kmjlz 232 20 disease disease NN cord-328289-3h3kmjlz 232 21 ( ( -LRB- cord-328289-3h3kmjlz 232 22 Song Song NNP cord-328289-3h3kmjlz 232 23 et et FW cord-328289-3h3kmjlz 232 24 al al NNP cord-328289-3h3kmjlz 232 25 . . NNP cord-328289-3h3kmjlz 232 26 , , , cord-328289-3h3kmjlz 232 27 2020 2020 CD cord-328289-3h3kmjlz 232 28 ) ) -RRB- cord-328289-3h3kmjlz 232 29 . . . cord-328289-3h3kmjlz 233 1 Hamsters hamster NNS cord-328289-3h3kmjlz 233 2 , , , cord-328289-3h3kmjlz 233 3 ferrets ferret NNS cord-328289-3h3kmjlz 233 4 , , , cord-328289-3h3kmjlz 233 5 cats cat NNS cord-328289-3h3kmjlz 233 6 and and CC cord-328289-3h3kmjlz 233 7 non non JJ cord-328289-3h3kmjlz 233 8 - - JJ cord-328289-3h3kmjlz 233 9 human human JJ cord-328289-3h3kmjlz 233 10 primates primate NNS cord-328289-3h3kmjlz 233 11 could could MD cord-328289-3h3kmjlz 233 12 be be VB cord-328289-3h3kmjlz 233 13 more more RBR cord-328289-3h3kmjlz 233 14 viable viable JJ cord-328289-3h3kmjlz 233 15 models model NNS cord-328289-3h3kmjlz 233 16 ( ( -LRB- cord-328289-3h3kmjlz 233 17 Lakdawala Lakdawala NNP cord-328289-3h3kmjlz 233 18 and and CC cord-328289-3h3kmjlz 233 19 Menachery Menachery NNP cord-328289-3h3kmjlz 233 20 , , , cord-328289-3h3kmjlz 233 21 2020 2020 CD cord-328289-3h3kmjlz 233 22 ) ) -RRB- cord-328289-3h3kmjlz 233 23 . . . cord-328289-3h3kmjlz 234 1 Reproducing reproduce VBG cord-328289-3h3kmjlz 234 2 the the DT cord-328289-3h3kmjlz 234 3 systemic systemic JJ cord-328289-3h3kmjlz 234 4 effects effect NNS cord-328289-3h3kmjlz 234 5 of of IN cord-328289-3h3kmjlz 234 6 the the DT cord-328289-3h3kmjlz 234 7 disease disease NN cord-328289-3h3kmjlz 234 8 would would MD cord-328289-3h3kmjlz 234 9 be be VB cord-328289-3h3kmjlz 234 10 critical critical JJ cord-328289-3h3kmjlz 234 11 for for IN cord-328289-3h3kmjlz 234 12 studying study VBG cord-328289-3h3kmjlz 234 13 the the DT cord-328289-3h3kmjlz 234 14 neurological neurological JJ cord-328289-3h3kmjlz 234 15 aspects aspect NNS cord-328289-3h3kmjlz 234 16 of of IN cord-328289-3h3kmjlz 234 17 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 234 18 . . . cord-328289-3h3kmjlz 235 1 In in IN cord-328289-3h3kmjlz 235 2 vitro vitro FW cord-328289-3h3kmjlz 235 3 approaches approach NNS cord-328289-3h3kmjlz 235 4 involving involve VBG cord-328289-3h3kmjlz 235 5 human human JJ cord-328289-3h3kmjlz 235 6 pluripotent pluripotent JJ cord-328289-3h3kmjlz 235 7 stem stem NN cord-328289-3h3kmjlz 235 8 cells cell NNS cord-328289-3h3kmjlz 235 9 organoids organoid NNS cord-328289-3h3kmjlz 235 10 and and CC cord-328289-3h3kmjlz 235 11 co co NNS cord-328289-3h3kmjlz 235 12 - - NNS cord-328289-3h3kmjlz 235 13 cultures culture NNS cord-328289-3h3kmjlz 235 14 are be VBP cord-328289-3h3kmjlz 235 15 useful useful JJ cord-328289-3h3kmjlz 235 16 to to TO cord-328289-3h3kmjlz 235 17 examine examine VB cord-328289-3h3kmjlz 235 18 infectious infectious JJ cord-328289-3h3kmjlz 235 19 mechanisms mechanism NNS cord-328289-3h3kmjlz 235 20 in in IN cord-328289-3h3kmjlz 235 21 brain brain NN cord-328289-3h3kmjlz 235 22 cells cell NNS cord-328289-3h3kmjlz 236 1 ( ( -LRB- cord-328289-3h3kmjlz 236 2 Song Song NNP cord-328289-3h3kmjlz 236 3 et et FW cord-328289-3h3kmjlz 236 4 al al NNP cord-328289-3h3kmjlz 236 5 . . NNP cord-328289-3h3kmjlz 236 6 , , , cord-328289-3h3kmjlz 236 7 2020 2020 CD cord-328289-3h3kmjlz 236 8 ; ; . cord-328289-3h3kmjlz 237 1 Yang Yang NNP cord-328289-3h3kmjlz 237 2 et et NNP cord-328289-3h3kmjlz 237 3 al al NNP cord-328289-3h3kmjlz 237 4 . . NNP cord-328289-3h3kmjlz 237 5 , , , cord-328289-3h3kmjlz 237 6 2020 2020 CD cord-328289-3h3kmjlz 237 7 ) ) -RRB- cord-328289-3h3kmjlz 237 8 , , , cord-328289-3h3kmjlz 237 9 but but CC cord-328289-3h3kmjlz 237 10 do do VBP cord-328289-3h3kmjlz 237 11 not not RB cord-328289-3h3kmjlz 237 12 provide provide VB cord-328289-3h3kmjlz 237 13 insight insight NN cord-328289-3h3kmjlz 237 14 into into IN cord-328289-3h3kmjlz 237 15 the the DT cord-328289-3h3kmjlz 237 16 harmful harmful JJ cord-328289-3h3kmjlz 237 17 systemic systemic JJ cord-328289-3h3kmjlz 237 18 effects effect NNS cord-328289-3h3kmjlz 237 19 . . . cord-328289-3h3kmjlz 238 1 Therefore therefore RB cord-328289-3h3kmjlz 238 2 , , , cord-328289-3h3kmjlz 238 3 there there EX cord-328289-3h3kmjlz 238 4 is be VBZ cord-328289-3h3kmjlz 238 5 a a DT cord-328289-3h3kmjlz 238 6 pressing press VBG cord-328289-3h3kmjlz 238 7 need need NN cord-328289-3h3kmjlz 238 8 to to TO cord-328289-3h3kmjlz 238 9 develop develop VB cord-328289-3h3kmjlz 238 10 animal animal NN cord-328289-3h3kmjlz 238 11 models model NNS cord-328289-3h3kmjlz 238 12 that that WDT cord-328289-3h3kmjlz 238 13 are be VBP cord-328289-3h3kmjlz 238 14 amenable amenable JJ cord-328289-3h3kmjlz 238 15 to to TO cord-328289-3h3kmjlz 238 16 investigate investigate VB cord-328289-3h3kmjlz 238 17 not not RB cord-328289-3h3kmjlz 238 18 only only RB cord-328289-3h3kmjlz 238 19 the the DT cord-328289-3h3kmjlz 238 20 effects effect NNS cord-328289-3h3kmjlz 238 21 of of IN cord-328289-3h3kmjlz 238 22 SARS SARS NNP cord-328289-3h3kmjlz 238 23 - - HYPH cord-328289-3h3kmjlz 238 24 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 238 25 on on IN cord-328289-3h3kmjlz 238 26 brain brain NN cord-328289-3h3kmjlz 238 27 cells cell NNS cord-328289-3h3kmjlz 238 28 , , , cord-328289-3h3kmjlz 238 29 but but CC cord-328289-3h3kmjlz 238 30 also also RB cord-328289-3h3kmjlz 238 31 the the DT cord-328289-3h3kmjlz 238 32 systemic systemic JJ cord-328289-3h3kmjlz 238 33 effects effect NNS cord-328289-3h3kmjlz 238 34 of of IN cord-328289-3h3kmjlz 238 35 the the DT cord-328289-3h3kmjlz 238 36 infection infection NN cord-328289-3h3kmjlz 238 37 and and CC cord-328289-3h3kmjlz 238 38 the the DT cord-328289-3h3kmjlz 238 39 long long JJ cord-328289-3h3kmjlz 238 40 - - HYPH cord-328289-3h3kmjlz 238 41 term term NN cord-328289-3h3kmjlz 238 42 neuropsychiatric neuropsychiatric JJ cord-328289-3h3kmjlz 238 43 consequences consequence NNS cord-328289-3h3kmjlz 238 44 . . . cord-328289-3h3kmjlz 239 1 Therapeutic therapeutic JJ cord-328289-3h3kmjlz 239 2 considerations consideration NNS cord-328289-3h3kmjlz 239 3 : : : cord-328289-3h3kmjlz 239 4 Until until IN cord-328289-3h3kmjlz 239 5 safe safe JJ cord-328289-3h3kmjlz 239 6 and and CC cord-328289-3h3kmjlz 239 7 effective effective JJ cord-328289-3h3kmjlz 239 8 vaccines vaccine NNS cord-328289-3h3kmjlz 239 9 are be VBP cord-328289-3h3kmjlz 239 10 developed develop VBN cord-328289-3h3kmjlz 239 11 , , , cord-328289-3h3kmjlz 239 12 therapeutic therapeutic JJ cord-328289-3h3kmjlz 239 13 efforts effort NNS cord-328289-3h3kmjlz 239 14 have have VBP cord-328289-3h3kmjlz 239 15 to to TO cord-328289-3h3kmjlz 239 16 focus focus VB cord-328289-3h3kmjlz 239 17 on on IN cord-328289-3h3kmjlz 239 18 antiviral antiviral JJ cord-328289-3h3kmjlz 239 19 agents agent NNS cord-328289-3h3kmjlz 239 20 and and CC cord-328289-3h3kmjlz 239 21 on on IN cord-328289-3h3kmjlz 239 22 how how WRB cord-328289-3h3kmjlz 239 23 to to TO cord-328289-3h3kmjlz 239 24 best best RB cord-328289-3h3kmjlz 239 25 manage manage VB cord-328289-3h3kmjlz 239 26 respiratory respiratory JJ cord-328289-3h3kmjlz 239 27 insufficiency insufficiency NN cord-328289-3h3kmjlz 239 28 , , , cord-328289-3h3kmjlz 239 29 organ organ NN cord-328289-3h3kmjlz 239 30 failure failure NN cord-328289-3h3kmjlz 239 31 , , , cord-328289-3h3kmjlz 239 32 hypercoagulable hypercoagulable JJ cord-328289-3h3kmjlz 239 33 state state NN cord-328289-3h3kmjlz 239 34 and and CC cord-328289-3h3kmjlz 239 35 immune immune JJ cord-328289-3h3kmjlz 239 36 dysregulation dysregulation NN cord-328289-3h3kmjlz 239 37 . . . cord-328289-3h3kmjlz 240 1 There there EX cord-328289-3h3kmjlz 240 2 is be VBZ cord-328289-3h3kmjlz 240 3 no no DT cord-328289-3h3kmjlz 240 4 specific specific JJ cord-328289-3h3kmjlz 240 5 treatment treatment NN cord-328289-3h3kmjlz 240 6 for for IN cord-328289-3h3kmjlz 240 7 the the DT cord-328289-3h3kmjlz 240 8 neurological neurological JJ cord-328289-3h3kmjlz 240 9 manifestations manifestation NNS cord-328289-3h3kmjlz 240 10 , , , cord-328289-3h3kmjlz 240 11 which which WDT cord-328289-3h3kmjlz 240 12 are be VBP cord-328289-3h3kmjlz 240 13 managed manage VBN cord-328289-3h3kmjlz 240 14 according accord VBG cord-328289-3h3kmjlz 240 15 to to IN cord-328289-3h3kmjlz 240 16 standard standard JJ cord-328289-3h3kmjlz 240 17 protocols protocol NNS cord-328289-3h3kmjlz 240 18 . . . cord-328289-3h3kmjlz 241 1 However however RB cord-328289-3h3kmjlz 241 2 , , , cord-328289-3h3kmjlz 241 3 since since IN cord-328289-3h3kmjlz 241 4 the the DT cord-328289-3h3kmjlz 241 5 neurological neurological JJ cord-328289-3h3kmjlz 241 6 complications complication NNS cord-328289-3h3kmjlz 241 7 emerge emerge VBP cord-328289-3h3kmjlz 241 8 mainly mainly RB cord-328289-3h3kmjlz 241 9 in in IN cord-328289-3h3kmjlz 241 10 severe severe JJ cord-328289-3h3kmjlz 241 11 systemic systemic JJ cord-328289-3h3kmjlz 241 12 disease disease NN cord-328289-3h3kmjlz 241 13 , , , cord-328289-3h3kmjlz 241 14 minimizing minimize VBG cord-328289-3h3kmjlz 241 15 hypoxia hypoxia NN cord-328289-3h3kmjlz 241 16 and and CC cord-328289-3h3kmjlz 241 17 protecting protect VBG cord-328289-3h3kmjlz 241 18 the the DT cord-328289-3h3kmjlz 241 19 brain brain NN cord-328289-3h3kmjlz 241 20 from from IN cord-328289-3h3kmjlz 241 21 cytokines cytokine NNS cord-328289-3h3kmjlz 241 22 , , , cord-328289-3h3kmjlz 241 23 DAMPs damp NNS cord-328289-3h3kmjlz 241 24 , , , cord-328289-3h3kmjlz 241 25 PAMPs pamp NNS cord-328289-3h3kmjlz 241 26 and and CC cord-328289-3h3kmjlz 241 27 thromboembolic thromboembolic JJ cord-328289-3h3kmjlz 241 28 complications complication NNS cord-328289-3h3kmjlz 241 29 are be VBP cord-328289-3h3kmjlz 241 30 important important JJ cord-328289-3h3kmjlz 241 31 therapeutic therapeutic JJ cord-328289-3h3kmjlz 241 32 goals goal NNS cord-328289-3h3kmjlz 241 33 . . . cord-328289-3h3kmjlz 242 1 Immunosuppression Immunosuppression NNP cord-328289-3h3kmjlz 242 2 with with IN cord-328289-3h3kmjlz 242 3 steroids steroid NNS cord-328289-3h3kmjlz 242 4 improves improve VBZ cord-328289-3h3kmjlz 242 5 mortality mortality NN cord-328289-3h3kmjlz 242 6 in in IN cord-328289-3h3kmjlz 242 7 patients patient NNS cord-328289-3h3kmjlz 242 8 with with IN cord-328289-3h3kmjlz 242 9 severe severe JJ cord-328289-3h3kmjlz 242 10 disease disease NN cord-328289-3h3kmjlz 242 11 , , , cord-328289-3h3kmjlz 242 12 but but CC cord-328289-3h3kmjlz 242 13 not not RB cord-328289-3h3kmjlz 242 14 in in IN cord-328289-3h3kmjlz 242 15 those those DT cord-328289-3h3kmjlz 242 16 with with IN cord-328289-3h3kmjlz 242 17 milder mild JJR cord-328289-3h3kmjlz 242 18 forms form NNS cord-328289-3h3kmjlz 242 19 ( ( -LRB- cord-328289-3h3kmjlz 242 20 Hayden Hayden NNP cord-328289-3h3kmjlz 242 21 , , , cord-328289-3h3kmjlz 242 22 2020 2020 CD cord-328289-3h3kmjlz 242 23 ) ) -RRB- cord-328289-3h3kmjlz 242 24 . . . cord-328289-3h3kmjlz 243 1 Furthermore furthermore RB cord-328289-3h3kmjlz 243 2 , , , cord-328289-3h3kmjlz 243 3 more more RBR cord-328289-3h3kmjlz 243 4 nuanced nuanced JJ cord-328289-3h3kmjlz 243 5 approaches approach NNS cord-328289-3h3kmjlz 243 6 to to TO cord-328289-3h3kmjlz 243 7 counteract counteract VB cord-328289-3h3kmjlz 243 8 the the DT cord-328289-3h3kmjlz 243 9 immune immune JJ cord-328289-3h3kmjlz 243 10 dysregulation dysregulation NN cord-328289-3h3kmjlz 243 11 , , , cord-328289-3h3kmjlz 243 12 such such JJ cord-328289-3h3kmjlz 243 13 as as IN cord-328289-3h3kmjlz 243 14 targeting target VBG cord-328289-3h3kmjlz 243 15 specific specific JJ cord-328289-3h3kmjlz 243 16 cytokines cytokine NNS cord-328289-3h3kmjlz 243 17 or or CC cord-328289-3h3kmjlz 243 18 inflammatory inflammatory JJ cord-328289-3h3kmjlz 243 19 pathways pathway NNS cord-328289-3h3kmjlz 243 20 are be VBP cord-328289-3h3kmjlz 243 21 also also RB cord-328289-3h3kmjlz 243 22 being be VBG cord-328289-3h3kmjlz 243 23 tested test VBN cord-328289-3h3kmjlz 244 1 ( ( -LRB- cord-328289-3h3kmjlz 244 2 Vabret Vabret NNP cord-328289-3h3kmjlz 244 3 et et NNP cord-328289-3h3kmjlz 244 4 al al NNP cord-328289-3h3kmjlz 244 5 . . NNP cord-328289-3h3kmjlz 244 6 , , , cord-328289-3h3kmjlz 244 7 2020 2020 CD cord-328289-3h3kmjlz 244 8 ) ) -RRB- cord-328289-3h3kmjlz 244 9 . . . cord-328289-3h3kmjlz 245 1 Whether whether IN cord-328289-3h3kmjlz 245 2 these these DT cord-328289-3h3kmjlz 245 3 interventions intervention NNS cord-328289-3h3kmjlz 245 4 reduce reduce VBP cord-328289-3h3kmjlz 245 5 the the DT cord-328289-3h3kmjlz 245 6 short short JJ cord-328289-3h3kmjlz 245 7 - - HYPH cord-328289-3h3kmjlz 245 8 and and CC cord-328289-3h3kmjlz 245 9 long long JJ cord-328289-3h3kmjlz 245 10 - - HYPH cord-328289-3h3kmjlz 245 11 term term NN cord-328289-3h3kmjlz 245 12 neurological neurological JJ cord-328289-3h3kmjlz 245 13 and and CC cord-328289-3h3kmjlz 245 14 psychiatric psychiatric JJ cord-328289-3h3kmjlz 245 15 complications complication NNS cord-328289-3h3kmjlz 245 16 remain remain VBP cord-328289-3h3kmjlz 245 17 to to TO cord-328289-3h3kmjlz 245 18 be be VB cord-328289-3h3kmjlz 245 19 established establish VBN cord-328289-3h3kmjlz 245 20 . . . cord-328289-3h3kmjlz 246 1 In in IN cord-328289-3h3kmjlz 246 2 conclusion conclusion NN cord-328289-3h3kmjlz 246 3 , , , cord-328289-3h3kmjlz 246 4 the the DT cord-328289-3h3kmjlz 246 5 neurological neurological JJ cord-328289-3h3kmjlz 246 6 manifestations manifestation NNS cord-328289-3h3kmjlz 246 7 of of IN cord-328289-3h3kmjlz 246 8 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 246 9 constitute constitute VBP cord-328289-3h3kmjlz 246 10 a a DT cord-328289-3h3kmjlz 246 11 major major JJ cord-328289-3h3kmjlz 246 12 public public JJ cord-328289-3h3kmjlz 246 13 health health NN cord-328289-3h3kmjlz 246 14 challenge challenge NN cord-328289-3h3kmjlz 246 15 not not RB cord-328289-3h3kmjlz 246 16 only only RB cord-328289-3h3kmjlz 246 17 for for IN cord-328289-3h3kmjlz 246 18 the the DT cord-328289-3h3kmjlz 246 19 acute acute JJ cord-328289-3h3kmjlz 246 20 effects effect NNS cord-328289-3h3kmjlz 246 21 on on IN cord-328289-3h3kmjlz 246 22 the the DT cord-328289-3h3kmjlz 246 23 brain brain NN cord-328289-3h3kmjlz 246 24 , , , cord-328289-3h3kmjlz 246 25 but but CC cord-328289-3h3kmjlz 246 26 also also RB cord-328289-3h3kmjlz 246 27 for for IN cord-328289-3h3kmjlz 246 28 the the DT cord-328289-3h3kmjlz 246 29 long long JJ cord-328289-3h3kmjlz 246 30 - - HYPH cord-328289-3h3kmjlz 246 31 term term NN cord-328289-3h3kmjlz 246 32 harm harm NN cord-328289-3h3kmjlz 246 33 to to IN cord-328289-3h3kmjlz 246 34 brain brain NN cord-328289-3h3kmjlz 246 35 health health NN cord-328289-3h3kmjlz 246 36 that that WDT cord-328289-3h3kmjlz 246 37 may may MD cord-328289-3h3kmjlz 246 38 ensue ensue VB cord-328289-3h3kmjlz 246 39 . . . cord-328289-3h3kmjlz 247 1 These these DT cord-328289-3h3kmjlz 247 2 delayed delay VBN cord-328289-3h3kmjlz 247 3 manifestations manifestation NNS cord-328289-3h3kmjlz 247 4 are be VBP cord-328289-3h3kmjlz 247 5 anticipated anticipate VBN cord-328289-3h3kmjlz 247 6 to to TO cord-328289-3h3kmjlz 247 7 be be VB cord-328289-3h3kmjlz 247 8 significant significant JJ cord-328289-3h3kmjlz 247 9 since since IN cord-328289-3h3kmjlz 247 10 they -PRON- PRP cord-328289-3h3kmjlz 247 11 are be VBP cord-328289-3h3kmjlz 247 12 likely likely JJ cord-328289-3h3kmjlz 247 13 to to TO cord-328289-3h3kmjlz 247 14 also also RB cord-328289-3h3kmjlz 247 15 affect affect VB cord-328289-3h3kmjlz 247 16 patients patient NNS cord-328289-3h3kmjlz 247 17 who who WP cord-328289-3h3kmjlz 247 18 did do VBD cord-328289-3h3kmjlz 247 19 not not RB cord-328289-3h3kmjlz 247 20 show show VB cord-328289-3h3kmjlz 247 21 neurological neurological JJ cord-328289-3h3kmjlz 247 22 symptoms symptom NNS cord-328289-3h3kmjlz 247 23 in in IN cord-328289-3h3kmjlz 247 24 the the DT cord-328289-3h3kmjlz 247 25 acute acute JJ cord-328289-3h3kmjlz 247 26 phase phase NN cord-328289-3h3kmjlz 247 27 . . . cord-328289-3h3kmjlz 248 1 Therefore therefore RB cord-328289-3h3kmjlz 248 2 , , , cord-328289-3h3kmjlz 248 3 clinical clinical JJ cord-328289-3h3kmjlz 248 4 and and CC cord-328289-3h3kmjlz 248 5 laboratory laboratory NN cord-328289-3h3kmjlz 248 6 efforts effort NNS cord-328289-3h3kmjlz 248 7 aiming aim VBG cord-328289-3h3kmjlz 248 8 to to TO cord-328289-3h3kmjlz 248 9 elucidate elucidate VB cord-328289-3h3kmjlz 248 10 the the DT cord-328289-3h3kmjlz 248 11 mechanisms mechanism NNS cord-328289-3h3kmjlz 248 12 of of IN cord-328289-3h3kmjlz 248 13 the the DT cord-328289-3h3kmjlz 248 14 acute acute JJ cord-328289-3h3kmjlz 248 15 effects effect NNS cord-328289-3h3kmjlz 248 16 on on IN cord-328289-3h3kmjlz 248 17 the the DT cord-328289-3h3kmjlz 248 18 brain brain NN cord-328289-3h3kmjlz 248 19 of of IN cord-328289-3h3kmjlz 248 20 SARS SARS NNP cord-328289-3h3kmjlz 248 21 - - HYPH cord-328289-3h3kmjlz 248 22 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 248 23 need need VB cord-328289-3h3kmjlz 248 24 to to TO cord-328289-3h3kmjlz 248 25 be be VB cord-328289-3h3kmjlz 248 26 coupled couple VBN cord-328289-3h3kmjlz 248 27 with with IN cord-328289-3h3kmjlz 248 28 investigations investigation NNS cord-328289-3h3kmjlz 248 29 on on IN cord-328289-3h3kmjlz 248 30 the the DT cord-328289-3h3kmjlz 248 31 deleterious deleterious JJ cord-328289-3h3kmjlz 248 32 delayed delay VBN cord-328289-3h3kmjlz 248 33 neuropsychiatric neuropsychiatric JJ cord-328289-3h3kmjlz 248 34 sequelae sequela NNS cord-328289-3h3kmjlz 248 35 of of IN cord-328289-3h3kmjlz 248 36 the the DT cord-328289-3h3kmjlz 248 37 infection infection NN cord-328289-3h3kmjlz 248 38 . . . cord-328289-3h3kmjlz 249 1 These these DT cord-328289-3h3kmjlz 249 2 efforts effort NNS cord-328289-3h3kmjlz 249 3 should should MD cord-328289-3h3kmjlz 249 4 be be VB cord-328289-3h3kmjlz 249 5 driven drive VBN cord-328289-3h3kmjlz 249 6 by by IN cord-328289-3h3kmjlz 249 7 a a DT cord-328289-3h3kmjlz 249 8 close close JJ cord-328289-3h3kmjlz 249 9 cooperation cooperation NN cord-328289-3h3kmjlz 249 10 between between IN cord-328289-3h3kmjlz 249 11 clinical clinical JJ cord-328289-3h3kmjlz 249 12 and and CC cord-328289-3h3kmjlz 249 13 basic basic JJ cord-328289-3h3kmjlz 249 14 scientists scientist NNS cord-328289-3h3kmjlz 249 15 and and CC cord-328289-3h3kmjlz 249 16 take take VB cord-328289-3h3kmjlz 249 17 advantage advantage NN cord-328289-3h3kmjlz 249 18 of of IN cord-328289-3h3kmjlz 249 19 the the DT cord-328289-3h3kmjlz 249 20 wealth wealth NN cord-328289-3h3kmjlz 249 21 of of IN cord-328289-3h3kmjlz 249 22 clinicalepidemiological clinicalepidemiological NNP cord-328289-3h3kmjlz 249 23 data datum NNS cord-328289-3h3kmjlz 249 24 and and CC cord-328289-3h3kmjlz 249 25 biological biological JJ cord-328289-3h3kmjlz 249 26 specimens specimen NNS cord-328289-3h3kmjlz 249 27 that that WDT cord-328289-3h3kmjlz 249 28 are be VBP cord-328289-3h3kmjlz 249 29 accumulating accumulate VBG cord-328289-3h3kmjlz 249 30 worldwide worldwide RB cord-328289-3h3kmjlz 249 31 . . . cord-328289-3h3kmjlz 250 1 Considering consider VBG cord-328289-3h3kmjlz 250 2 that that IN cord-328289-3h3kmjlz 250 3 COVID-19 covid-19 NN cord-328289-3h3kmjlz 250 4 is be VBZ cord-328289-3h3kmjlz 250 5 still still RB cord-328289-3h3kmjlz 250 6 raging rage VBG cord-328289-3h3kmjlz 250 7 in in IN cord-328289-3h3kmjlz 250 8 many many JJ cord-328289-3h3kmjlz 250 9 countries country NNS cord-328289-3h3kmjlz 250 10 , , , cord-328289-3h3kmjlz 250 11 including include VBG cord-328289-3h3kmjlz 250 12 the the DT cord-328289-3h3kmjlz 250 13 US US NNP cord-328289-3h3kmjlz 250 14 , , , cord-328289-3h3kmjlz 250 15 and and CC cord-328289-3h3kmjlz 250 16 that that IN cord-328289-3h3kmjlz 250 17 there there EX cord-328289-3h3kmjlz 250 18 might may MD cord-328289-3h3kmjlz 250 19 be be VB cord-328289-3h3kmjlz 250 20 a a DT cord-328289-3h3kmjlz 250 21 seasonal seasonal JJ cord-328289-3h3kmjlz 250 22 resurgence resurgence NN cord-328289-3h3kmjlz 250 23 of of IN cord-328289-3h3kmjlz 250 24 infection infection NN cord-328289-3h3kmjlz 250 25 , , , cord-328289-3h3kmjlz 250 26 it -PRON- PRP cord-328289-3h3kmjlz 250 27 is be VBZ cord-328289-3h3kmjlz 250 28 imperative imperative JJ cord-328289-3h3kmjlz 250 29 that that IN cord-328289-3h3kmjlz 250 30 a a DT cord-328289-3h3kmjlz 250 31 such such JJ cord-328289-3h3kmjlz 250 32 a a DT cord-328289-3h3kmjlz 250 33 concerted concerted JJ cord-328289-3h3kmjlz 250 34 effort effort NN cord-328289-3h3kmjlz 250 35 is be VBZ cord-328289-3h3kmjlz 250 36 implemented implement VBN cord-328289-3h3kmjlz 250 37 swiftly swiftly RB cord-328289-3h3kmjlz 250 38 and and CC cord-328289-3h3kmjlz 250 39 on on IN cord-328289-3h3kmjlz 250 40 a a DT cord-328289-3h3kmjlz 250 41 large large JJ cord-328289-3h3kmjlz 250 42 scale scale NN cord-328289-3h3kmjlz 250 43 . . . cord-328289-3h3kmjlz 251 1 Dr. Dr. NNP cord-328289-3h3kmjlz 251 2 Iadecola Iadecola NNP cord-328289-3h3kmjlz 251 3 serves serve VBZ cord-328289-3h3kmjlz 251 4 on on IN cord-328289-3h3kmjlz 251 5 the the DT cord-328289-3h3kmjlz 251 6 Scientific Scientific NNP cord-328289-3h3kmjlz 251 7 Advisory Advisory NNP cord-328289-3h3kmjlz 251 8 Board Board NNP cord-328289-3h3kmjlz 251 9 of of IN cord-328289-3h3kmjlz 251 10 Broadview Broadview NNP cord-328289-3h3kmjlz 251 11 Ventures Ventures NNPS cord-328289-3h3kmjlz 251 12 . . . cord-328289-3h3kmjlz 252 1 Dr. Dr. NNP cord-328289-3h3kmjlz 252 2 Kamel Kamel NNP cord-328289-3h3kmjlz 252 3 serves serve VBZ cord-328289-3h3kmjlz 252 4 as as IN cord-328289-3h3kmjlz 252 5 co co NN cord-328289-3h3kmjlz 252 6 - - NN cord-328289-3h3kmjlz 252 7 PI pi NN cord-328289-3h3kmjlz 252 8 for for IN cord-328289-3h3kmjlz 252 9 the the DT cord-328289-3h3kmjlz 252 10 NIH NIH NNP cord-328289-3h3kmjlz 252 11 - - HYPH cord-328289-3h3kmjlz 252 12 funded fund VBN cord-328289-3h3kmjlz 252 13 ARCADIA ARCADIA NNP cord-328289-3h3kmjlz 252 14 trial trial NN cord-328289-3h3kmjlz 252 15 ( ( -LRB- cord-328289-3h3kmjlz 252 16 NINDS NINDS NNP cord-328289-3h3kmjlz 252 17 U01NS095869 U01NS095869 NNP cord-328289-3h3kmjlz 252 18 ) ) -RRB- cord-328289-3h3kmjlz 252 19 which which WDT cord-328289-3h3kmjlz 252 20 receives receive VBZ cord-328289-3h3kmjlz 252 21 in in IN cord-328289-3h3kmjlz 252 22 - - HYPH cord-328289-3h3kmjlz 252 23 kind kind NN cord-328289-3h3kmjlz 252 24 study study NN cord-328289-3h3kmjlz 252 25 drug drug NN cord-328289-3h3kmjlz 252 26 from from IN cord-328289-3h3kmjlz 252 27 the the DT cord-328289-3h3kmjlz 252 28 BMS BMS NNP cord-328289-3h3kmjlz 252 29 - - HYPH cord-328289-3h3kmjlz 252 30 Pfizer Pfizer NNP cord-328289-3h3kmjlz 252 31 Alliance Alliance NNP cord-328289-3h3kmjlz 252 32 for for IN cord-328289-3h3kmjlz 252 33 Eliquis Eliquis NNP cord-328289-3h3kmjlz 252 34 ® ® . cord-328289-3h3kmjlz 252 35 and and CC cord-328289-3h3kmjlz 252 36 ancillary ancillary JJ cord-328289-3h3kmjlz 252 37 study study NN cord-328289-3h3kmjlz 252 38 support support NN cord-328289-3h3kmjlz 252 39 from from IN cord-328289-3h3kmjlz 252 40 Roche Roche NNP cord-328289-3h3kmjlz 252 41 Diagnostics Diagnostics NNP cord-328289-3h3kmjlz 252 42 , , , cord-328289-3h3kmjlz 252 43 serves serve VBZ cord-328289-3h3kmjlz 252 44 as as IN cord-328289-3h3kmjlz 252 45 Deputy Deputy NNP cord-328289-3h3kmjlz 252 46 Editor Editor NNP cord-328289-3h3kmjlz 252 47 for for IN cord-328289-3h3kmjlz 252 48 JAMA JAMA NNP cord-328289-3h3kmjlz 252 49 Neurology Neurology NNP cord-328289-3h3kmjlz 252 50 , , , cord-328289-3h3kmjlz 252 51 serves serve VBZ cord-328289-3h3kmjlz 252 52 as as IN cord-328289-3h3kmjlz 252 53 a a DT cord-328289-3h3kmjlz 252 54 steering steering NN cord-328289-3h3kmjlz 252 55 committee committee NN cord-328289-3h3kmjlz 252 56 member member NN cord-328289-3h3kmjlz 252 57 of of IN cord-328289-3h3kmjlz 252 58 Medtronic Medtronic NNP cord-328289-3h3kmjlz 252 59 's 's POS cord-328289-3h3kmjlz 252 60 Stroke Stroke NNP cord-328289-3h3kmjlz 252 61 AF AF NNP cord-328289-3h3kmjlz 252 62 trial trial NN cord-328289-3h3kmjlz 252 63 ( ( -LRB- cord-328289-3h3kmjlz 252 64 uncompensated uncompensated JJ cord-328289-3h3kmjlz 252 65 ) ) -RRB- cord-328289-3h3kmjlz 252 66 , , , cord-328289-3h3kmjlz 252 67 serves serve VBZ cord-328289-3h3kmjlz 252 68 on on IN cord-328289-3h3kmjlz 252 69 an an DT cord-328289-3h3kmjlz 252 70 endpoint endpoint NN cord-328289-3h3kmjlz 252 71 adjudication adjudication NN cord-328289-3h3kmjlz 252 72 committee committee NN cord-328289-3h3kmjlz 252 73 for for IN cord-328289-3h3kmjlz 252 74 a a DT cord-328289-3h3kmjlz 252 75 trial trial NN cord-328289-3h3kmjlz 252 76 of of IN cord-328289-3h3kmjlz 252 77 empagliflozin empagliflozin NNP cord-328289-3h3kmjlz 252 78 for for IN cord-328289-3h3kmjlz 252 79 Boehringer Boehringer NNP cord-328289-3h3kmjlz 252 80 - - HYPH cord-328289-3h3kmjlz 252 81 Ingelheim Ingelheim NNP cord-328289-3h3kmjlz 252 82 , , , cord-328289-3h3kmjlz 252 83 and and CC cord-328289-3h3kmjlz 252 84 has have VBZ cord-328289-3h3kmjlz 252 85 served serve VBN cord-328289-3h3kmjlz 252 86 on on IN cord-328289-3h3kmjlz 252 87 an an DT cord-328289-3h3kmjlz 252 88 advisory advisory JJ cord-328289-3h3kmjlz 252 89 board board NN cord-328289-3h3kmjlz 252 90 for for IN cord-328289-3h3kmjlz 252 91 Roivant Roivant NNP cord-328289-3h3kmjlz 252 92 Sciences Sciences NNP cord-328289-3h3kmjlz 252 93 related relate VBN cord-328289-3h3kmjlz 252 94 to to IN cord-328289-3h3kmjlz 252 95 Factor Factor NNP cord-328289-3h3kmjlz 252 96 XI XI NNP cord-328289-3h3kmjlz 252 97 inhibition inhibition NN cord-328289-3h3kmjlz 252 98 . . . cord-328289-3h3kmjlz 253 1 Dr. Dr. NNP cord-328289-3h3kmjlz 253 2 Anrather Anrather NNP cord-328289-3h3kmjlz 253 3 has have VBZ cord-328289-3h3kmjlz 253 4 no no DT cord-328289-3h3kmjlz 253 5 conflict conflict NN cord-328289-3h3kmjlz 253 6 of of IN cord-328289-3h3kmjlz 253 7 interests interest NNS cord-328289-3h3kmjlz 253 8 to to TO cord-328289-3h3kmjlz 253 9 declare declare VB cord-328289-3h3kmjlz 253 10 . . . cord-328289-3h3kmjlz 254 1 J J NNP cord-328289-3h3kmjlz 254 2 o o NN cord-328289-3h3kmjlz 254 3 u u NN cord-328289-3h3kmjlz 254 4 r r NN cord-328289-3h3kmjlz 254 5 n n NN cord-328289-3h3kmjlz 254 6 a a DT cord-328289-3h3kmjlz 254 7 l l NN cord-328289-3h3kmjlz 254 8 P p NN cord-328289-3h3kmjlz 254 9 r r NN cord-328289-3h3kmjlz 254 10 e e NN cord-328289-3h3kmjlz 254 11 -p -p NN cord-328289-3h3kmjlz 255 1 r r NN cord-328289-3h3kmjlz 255 2 o o NN cord-328289-3h3kmjlz 255 3 o o NN cord-328289-3h3kmjlz 255 4 f f NN cord-328289-3h3kmjlz 256 1 In in IN cord-328289-3h3kmjlz 256 2 a a DT cord-328289-3h3kmjlz 256 3 single single JJ cord-328289-3h3kmjlz 256 4 nuclear nuclear JJ cord-328289-3h3kmjlz 256 5 RNA rna NN cord-328289-3h3kmjlz 256 6 - - HYPH cord-328289-3h3kmjlz 256 7 seq seq NN cord-328289-3h3kmjlz 256 8 profile profile NN cord-328289-3h3kmjlz 256 9 of of IN cord-328289-3h3kmjlz 256 10 human human JJ cord-328289-3h3kmjlz 256 11 cortical cortical JJ cord-328289-3h3kmjlz 256 12 brain brain NN cord-328289-3h3kmjlz 256 13 tissue tissue NN cord-328289-3h3kmjlz 256 14 ( ( -LRB- cord-328289-3h3kmjlz 256 15 https://celltypes.brain-map.org https://celltypes.brain-map.org NN cord-328289-3h3kmjlz 256 16 ) ) -RRB- cord-328289-3h3kmjlz 257 1 ( ( -LRB- cord-328289-3h3kmjlz 257 2 Hodge Hodge NNP cord-328289-3h3kmjlz 257 3 et et NNP cord-328289-3h3kmjlz 257 4 al al NNP cord-328289-3h3kmjlz 257 5 . . NNP cord-328289-3h3kmjlz 257 6 , , , cord-328289-3h3kmjlz 257 7 2019 2019 CD cord-328289-3h3kmjlz 257 8 ) ) -RRB- cord-328289-3h3kmjlz 258 1 there there EX cord-328289-3h3kmjlz 258 2 was be VBD cord-328289-3h3kmjlz 258 3 no no DT cord-328289-3h3kmjlz 258 4 evidence evidence NN cord-328289-3h3kmjlz 258 5 of of IN cord-328289-3h3kmjlz 258 6 ACE2 ACE2 NNP cord-328289-3h3kmjlz 258 7 expression expression NN cord-328289-3h3kmjlz 258 8 in in IN cord-328289-3h3kmjlz 258 9 any any DT cord-328289-3h3kmjlz 258 10 brain brain NN cord-328289-3h3kmjlz 258 11 cell cell NN cord-328289-3h3kmjlz 258 12 type type NN cord-328289-3h3kmjlz 258 13 . . . cord-328289-3h3kmjlz 259 1 Basigin Basigin NNP cord-328289-3h3kmjlz 259 2 ( ( -LRB- cord-328289-3h3kmjlz 259 3 BSG BSG NNP cord-328289-3h3kmjlz 259 4 ) ) -RRB- cord-328289-3h3kmjlz 259 5 was be VBD cord-328289-3h3kmjlz 259 6 prominently prominently RB cord-328289-3h3kmjlz 259 7 expressed express VBN cord-328289-3h3kmjlz 259 8 in in IN cord-328289-3h3kmjlz 259 9 pericytes pericyte NNS cord-328289-3h3kmjlz 259 10 and and CC cord-328289-3h3kmjlz 259 11 endothelial endothelial JJ cord-328289-3h3kmjlz 259 12 cells cell NNS cord-328289-3h3kmjlz 259 13 , , , cord-328289-3h3kmjlz 259 14 while while IN cord-328289-3h3kmjlz 259 15 neuropilin-1 neuropilin-1 NNP cord-328289-3h3kmjlz 259 16 ( ( -LRB- cord-328289-3h3kmjlz 259 17 NRP1 NRP1 NNP cord-328289-3h3kmjlz 259 18 ) ) -RRB- cord-328289-3h3kmjlz 259 19 was be VBD cord-328289-3h3kmjlz 259 20 detected detect VBN cord-328289-3h3kmjlz 259 21 in in IN cord-328289-3h3kmjlz 259 22 endothelial endothelial JJ cord-328289-3h3kmjlz 259 23 cells cell NNS cord-328289-3h3kmjlz 259 24 and and CC cord-328289-3h3kmjlz 259 25 in in IN cord-328289-3h3kmjlz 259 26 several several JJ cord-328289-3h3kmjlz 259 27 classes class NNS cord-328289-3h3kmjlz 259 28 of of IN cord-328289-3h3kmjlz 259 29 excitatory excitatory JJ cord-328289-3h3kmjlz 259 30 neurons neuron NNS cord-328289-3h3kmjlz 259 31 . . . cord-328289-3h3kmjlz 260 1 Low low JJ cord-328289-3h3kmjlz 260 2 expression expression NN cord-328289-3h3kmjlz 260 3 of of IN cord-328289-3h3kmjlz 260 4 TMPRSS11A tmprss11a NN cord-328289-3h3kmjlz 260 5 and and CC cord-328289-3h3kmjlz 260 6 FURIN FURIN NNP cord-328289-3h3kmjlz 260 7 was be VBD cord-328289-3h3kmjlz 260 8 found find VBN cord-328289-3h3kmjlz 260 9 in in IN cord-328289-3h3kmjlz 260 10 neurons neuron NNS cord-328289-3h3kmjlz 260 11 , , , cord-328289-3h3kmjlz 260 12 while while IN cord-328289-3h3kmjlz 260 13 CSTB CSTB NNP cord-328289-3h3kmjlz 260 14 was be VBD cord-328289-3h3kmjlz 260 15 moderately moderately RB cord-328289-3h3kmjlz 260 16 expressed express VBN cord-328289-3h3kmjlz 260 17 in in IN cord-328289-3h3kmjlz 260 18 most most JJS cord-328289-3h3kmjlz 260 19 cell cell NN cord-328289-3h3kmjlz 260 20 types type NNS cord-328289-3h3kmjlz 260 21 with with IN cord-328289-3h3kmjlz 260 22 the the DT cord-328289-3h3kmjlz 260 23 exception exception NN cord-328289-3h3kmjlz 260 24 of of IN cord-328289-3h3kmjlz 260 25 astrocytes astrocyte NNS cord-328289-3h3kmjlz 260 26 and and CC cord-328289-3h3kmjlz 260 27 oligodendrocytes oligodendrocyte NNS cord-328289-3h3kmjlz 260 28 and and CC cord-328289-3h3kmjlz 260 29 their -PRON- PRP$ cord-328289-3h3kmjlz 260 30 precursors precursor NNS cord-328289-3h3kmjlz 260 31 . . . cord-328289-3h3kmjlz 261 1 Endothelial endothelial JJ cord-328289-3h3kmjlz 261 2 cells cell NNS cord-328289-3h3kmjlz 261 3 and and CC cord-328289-3h3kmjlz 261 4 pericytes pericyte NNS cord-328289-3h3kmjlz 261 5 also also RB cord-328289-3h3kmjlz 261 6 express express VBP cord-328289-3h3kmjlz 261 7 lymphocyte lymphocyte NN cord-328289-3h3kmjlz 261 8 antigen antigen NNP cord-328289-3h3kmjlz 261 9 6 6 CD cord-328289-3h3kmjlz 261 10 family family NN cord-328289-3h3kmjlz 261 11 member member NN cord-328289-3h3kmjlz 261 12 E E NNP cord-328289-3h3kmjlz 261 13 ( ( -LRB- cord-328289-3h3kmjlz 261 14 LY6E LY6E NNP cord-328289-3h3kmjlz 261 15 ) ) -RRB- cord-328289-3h3kmjlz 261 16 , , , cord-328289-3h3kmjlz 261 17 and and CC cord-328289-3h3kmjlz 261 18 the the DT cord-328289-3h3kmjlz 261 19 interferon interferon NN cord-328289-3h3kmjlz 261 20 ( ( -LRB- cord-328289-3h3kmjlz 261 21 IFN)-induced ifn)-induce VBN cord-328289-3h3kmjlz 261 22 transmembrane transmembrane NN cord-328289-3h3kmjlz 261 23 proteins-1 proteins-1 NNP cord-328289-3h3kmjlz 261 24 and and CC cord-328289-3h3kmjlz 261 25 3 3 CD cord-328289-3h3kmjlz 261 26 ( ( -LRB- cord-328289-3h3kmjlz 261 27 IFITM1 ifitm1 UH cord-328289-3h3kmjlz 261 28 , , , cord-328289-3h3kmjlz 261 29 IFITM3 IFITM3 '' cord-328289-3h3kmjlz 261 30 ) ) -RRB- cord-328289-3h3kmjlz 261 31 , , , cord-328289-3h3kmjlz 261 32 that that WDT cord-328289-3h3kmjlz 261 33 have have VBP cord-328289-3h3kmjlz 261 34 been be VBN cord-328289-3h3kmjlz 261 35 shown show VBN cord-328289-3h3kmjlz 261 36 to to TO cord-328289-3h3kmjlz 261 37 restrict restrict VB cord-328289-3h3kmjlz 261 38 SARS SARS NNP cord-328289-3h3kmjlz 261 39 - - HYPH cord-328289-3h3kmjlz 261 40 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 261 41 cell cell NN cord-328289-3h3kmjlz 261 42 entry entry NN cord-328289-3h3kmjlz 262 1 ( ( -LRB- cord-328289-3h3kmjlz 262 2 Hachim Hachim NNP cord-328289-3h3kmjlz 262 3 et et NNP cord-328289-3h3kmjlz 262 4 al al NNP cord-328289-3h3kmjlz 262 5 . . NNP cord-328289-3h3kmjlz 262 6 , , , cord-328289-3h3kmjlz 262 7 2020 2020 CD cord-328289-3h3kmjlz 262 8 ; ; : cord-328289-3h3kmjlz 262 9 Pfaender Pfaender NNP cord-328289-3h3kmjlz 262 10 et et NNP cord-328289-3h3kmjlz 262 11 al al NNP cord-328289-3h3kmjlz 262 12 . . NNP cord-328289-3h3kmjlz 262 13 , , , cord-328289-3h3kmjlz 262 14 2020 2020 CD cord-328289-3h3kmjlz 262 15 ; ; . cord-328289-3h3kmjlz 263 1 Zhao Zhao NNP cord-328289-3h3kmjlz 263 2 et et NNP cord-328289-3h3kmjlz 263 3 al al NNP cord-328289-3h3kmjlz 263 4 . . NNP cord-328289-3h3kmjlz 263 5 , , , cord-328289-3h3kmjlz 263 6 2020 2020 CD cord-328289-3h3kmjlz 263 7 ) ) -RRB- cord-328289-3h3kmjlz 263 8 . . . cord-328289-3h3kmjlz 264 1 IFN IFN NNP cord-328289-3h3kmjlz 264 2 type type NN cord-328289-3h3kmjlz 264 3 I -PRON- PRP cord-328289-3h3kmjlz 264 4 receptors receptor NNS cord-328289-3h3kmjlz 264 5 ( ( -LRB- cord-328289-3h3kmjlz 264 6 IFNRA1 IFNRA1 NNP cord-328289-3h3kmjlz 264 7 and and CC cord-328289-3h3kmjlz 264 8 IFNRA2 IFNRA2 NNP cord-328289-3h3kmjlz 264 9 ) ) -RRB- cord-328289-3h3kmjlz 264 10 showed show VBD cord-328289-3h3kmjlz 264 11 higher high JJR cord-328289-3h3kmjlz 264 12 expression expression NN cord-328289-3h3kmjlz 264 13 in in IN cord-328289-3h3kmjlz 264 14 endothelial endothelial JJ cord-328289-3h3kmjlz 264 15 cells cell NNS cord-328289-3h3kmjlz 264 16 than than IN cord-328289-3h3kmjlz 264 17 other other JJ cord-328289-3h3kmjlz 264 18 cell cell NN cord-328289-3h3kmjlz 264 19 types type NNS cord-328289-3h3kmjlz 264 20 . . . cord-328289-3h3kmjlz 265 1 Cell cell NN cord-328289-3h3kmjlz 265 2 cluster cluster NN cord-328289-3h3kmjlz 265 3 annotations annotation NNS cord-328289-3h3kmjlz 265 4 are be VBP cord-328289-3h3kmjlz 265 5 from from IN cord-328289-3h3kmjlz 265 6 ( ( -LRB- cord-328289-3h3kmjlz 265 7 Hodge Hodge NNP cord-328289-3h3kmjlz 265 8 et et NNP cord-328289-3h3kmjlz 265 9 al al NNP cord-328289-3h3kmjlz 265 10 . . NNP cord-328289-3h3kmjlz 265 11 , , , cord-328289-3h3kmjlz 265 12 2019 2019 CD cord-328289-3h3kmjlz 265 13 ) ) -RRB- cord-328289-3h3kmjlz 265 14 . . . cord-328289-3h3kmjlz 266 1 CPM CPM NNP cord-328289-3h3kmjlz 266 2 , , , cord-328289-3h3kmjlz 266 3 transcript transcript NN cord-328289-3h3kmjlz 266 4 counts count VBZ cord-328289-3h3kmjlz 266 5 per per IN cord-328289-3h3kmjlz 266 6 million million CD cord-328289-3h3kmjlz 266 7 within within IN cord-328289-3h3kmjlz 266 8 the the DT cord-328289-3h3kmjlz 266 9 cell cell NN cord-328289-3h3kmjlz 266 10 cluster cluster NN cord-328289-3h3kmjlz 266 11 ; ; : cord-328289-3h3kmjlz 266 12 FracCellExpr fraccellexpr JJ cord-328289-3h3kmjlz 266 13 , , , cord-328289-3h3kmjlz 266 14 fraction fraction NN cord-328289-3h3kmjlz 266 15 of of IN cord-328289-3h3kmjlz 266 16 cells cell NNS cord-328289-3h3kmjlz 266 17 in in IN cord-328289-3h3kmjlz 266 18 which which WDT cord-328289-3h3kmjlz 266 19 the the DT cord-328289-3h3kmjlz 266 20 transcript transcript NN cord-328289-3h3kmjlz 266 21 is be VBZ cord-328289-3h3kmjlz 266 22 detected detect VBN cord-328289-3h3kmjlz 266 23 . . . cord-328289-3h3kmjlz 267 1 Circulating circulate VBG cord-328289-3h3kmjlz 267 2 virus virus NN cord-328289-3h3kmjlz 267 3 , , , cord-328289-3h3kmjlz 267 4 cytokines cytokine NNS cord-328289-3h3kmjlz 267 5 , , , cord-328289-3h3kmjlz 267 6 DAMPs damp NNS cord-328289-3h3kmjlz 267 7 and and CC cord-328289-3h3kmjlz 267 8 PAMPs pamp NNS cord-328289-3h3kmjlz 267 9 could could MD cord-328289-3h3kmjlz 267 10 act act VB cord-328289-3h3kmjlz 267 11 on on IN cord-328289-3h3kmjlz 267 12 endothelial endothelial JJ cord-328289-3h3kmjlz 267 13 cells cell NNS cord-328289-3h3kmjlz 267 14 leading lead VBG cord-328289-3h3kmjlz 267 15 to to IN cord-328289-3h3kmjlz 267 16 inflammation inflammation NN cord-328289-3h3kmjlz 267 17 and and CC cord-328289-3h3kmjlz 267 18 opening opening NN cord-328289-3h3kmjlz 267 19 of of IN cord-328289-3h3kmjlz 267 20 the the DT cord-328289-3h3kmjlz 267 21 BBB BBB NNP cord-328289-3h3kmjlz 267 22 . . . cord-328289-3h3kmjlz 268 1 Once once RB cord-328289-3h3kmjlz 268 2 in in IN cord-328289-3h3kmjlz 268 3 the the DT cord-328289-3h3kmjlz 268 4 perivascular perivascular JJ cord-328289-3h3kmjlz 268 5 space space NN cord-328289-3h3kmjlz 268 6 and and CC cord-328289-3h3kmjlz 268 7 these these DT cord-328289-3h3kmjlz 268 8 factors factor NNS cord-328289-3h3kmjlz 268 9 could could MD cord-328289-3h3kmjlz 268 10 induce induce VB cord-328289-3h3kmjlz 268 11 inflammation inflammation NN cord-328289-3h3kmjlz 268 12 in in IN cord-328289-3h3kmjlz 268 13 vascular vascular JJ cord-328289-3h3kmjlz 268 14 mural mural NN cord-328289-3h3kmjlz 268 15 cells cell NNS cord-328289-3h3kmjlz 268 16 and and CC cord-328289-3h3kmjlz 268 17 brain brain NN cord-328289-3h3kmjlz 268 18 resident resident NN cord-328289-3h3kmjlz 268 19 myeloid myeloid NN cord-328289-3h3kmjlz 268 20 cells cell NNS cord-328289-3h3kmjlz 268 21 ( ( -LRB- cord-328289-3h3kmjlz 268 22 microglia microglia NNS cord-328289-3h3kmjlz 268 23 and and CC cord-328289-3h3kmjlz 268 24 macrophages macrophage NNS cord-328289-3h3kmjlz 268 25 ) ) -RRB- cord-328289-3h3kmjlz 268 26 . . . cord-328289-3h3kmjlz 269 1 The the DT cord-328289-3h3kmjlz 269 2 resulting result VBG cord-328289-3h3kmjlz 269 3 cytokine cytokine NN cord-328289-3h3kmjlz 269 4 production production NN cord-328289-3h3kmjlz 269 5 could could MD cord-328289-3h3kmjlz 269 6 affect affect VB cord-328289-3h3kmjlz 269 7 neuron neuron NN cord-328289-3h3kmjlz 269 8 neuronal neuronal JJ cord-328289-3h3kmjlz 269 9 function function NN cord-328289-3h3kmjlz 269 10 leading lead VBG cord-328289-3h3kmjlz 269 11 to to IN cord-328289-3h3kmjlz 269 12 the the DT cord-328289-3h3kmjlz 269 13 cytokine cytokine NN cord-328289-3h3kmjlz 269 14 sickness sickness NN cord-328289-3h3kmjlz 269 15 , , , cord-328289-3h3kmjlz 269 16 a a DT cord-328289-3h3kmjlz 269 17 potential potential JJ cord-328289-3h3kmjlz 269 18 cause cause NN cord-328289-3h3kmjlz 269 19 of of IN cord-328289-3h3kmjlz 269 20 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 269 21 in in IN cord-328289-3h3kmjlz 269 22 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 269 23 . . . cord-328289-3h3kmjlz 270 1 Cytokine Cytokine NNP cord-328289-3h3kmjlz 270 2 and and CC cord-328289-3h3kmjlz 270 3 SARS SARS NNP cord-328289-3h3kmjlz 270 4 - - HYPH cord-328289-3h3kmjlz 270 5 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 270 6 entry entry NN cord-328289-3h3kmjlz 270 7 into into IN cord-328289-3h3kmjlz 270 8 the the DT cord-328289-3h3kmjlz 270 9 median median JJ cord-328289-3h3kmjlz 270 10 eminence eminence NN cord-328289-3h3kmjlz 270 11 of of IN cord-328289-3h3kmjlz 270 12 the the DT cord-328289-3h3kmjlz 270 13 hypothalamus hypothalamus NN cord-328289-3h3kmjlz 270 14 could could MD cord-328289-3h3kmjlz 270 15 lead lead VB cord-328289-3h3kmjlz 270 16 to to IN cord-328289-3h3kmjlz 270 17 activation activation NN cord-328289-3h3kmjlz 270 18 of of IN cord-328289-3h3kmjlz 270 19 the the DT cord-328289-3h3kmjlz 270 20 autonomic autonomic JJ cord-328289-3h3kmjlz 270 21 nervous nervous JJ cord-328289-3h3kmjlz 270 22 system system NN cord-328289-3h3kmjlz 270 23 and and CC cord-328289-3h3kmjlz 270 24 release release NN cord-328289-3h3kmjlz 270 25 of of IN cord-328289-3h3kmjlz 270 26 adrenal adrenal JJ cord-328289-3h3kmjlz 270 27 catecholamines catecholamine NNS cord-328289-3h3kmjlz 270 28 and and CC cord-328289-3h3kmjlz 270 29 steroids steroid NNS cord-328289-3h3kmjlz 270 30 . . . cord-328289-3h3kmjlz 271 1 In in IN cord-328289-3h3kmjlz 271 2 analogy analogy NN cord-328289-3h3kmjlz 271 3 with with IN cord-328289-3h3kmjlz 271 4 stroke stroke NN cord-328289-3h3kmjlz 271 5 , , , cord-328289-3h3kmjlz 271 6 brain brain NN cord-328289-3h3kmjlz 271 7 trauma trauma NN cord-328289-3h3kmjlz 271 8 and and CC cord-328289-3h3kmjlz 271 9 myocardial myocardial JJ cord-328289-3h3kmjlz 271 10 infarction infarction NN cord-328289-3h3kmjlz 271 11 , , , cord-328289-3h3kmjlz 271 12 these these DT cord-328289-3h3kmjlz 271 13 neurohumoral neurohumoral JJ cord-328289-3h3kmjlz 271 14 effectors effector NNS cord-328289-3h3kmjlz 271 15 could could MD cord-328289-3h3kmjlz 271 16 act act VB cord-328289-3h3kmjlz 271 17 on on IN cord-328289-3h3kmjlz 271 18 the the DT cord-328289-3h3kmjlz 271 19 bone bone NN cord-328289-3h3kmjlz 271 20 marrow marrow NN cord-328289-3h3kmjlz 271 21 to to TO cord-328289-3h3kmjlz 271 22 release release NN cord-328289-3h3kmjlz 271 23 of of IN cord-328289-3h3kmjlz 271 24 immunosuppressor immunosuppressor NNP cord-328289-3h3kmjlz 271 25 neutrophils neutrophil NNS cord-328289-3h3kmjlz 271 26 and and CC cord-328289-3h3kmjlz 271 27 myeloid myeloid NN cord-328289-3h3kmjlz 271 28 cells cell NNS cord-328289-3h3kmjlz 271 29 ( ( -LRB- cord-328289-3h3kmjlz 271 30 emergency emergency NN cord-328289-3h3kmjlz 271 31 myelopoiesis myelopoiesis NN cord-328289-3h3kmjlz 271 32 ) ) -RRB- cord-328289-3h3kmjlz 271 33 , , , cord-328289-3h3kmjlz 271 34 as as IN cord-328289-3h3kmjlz 271 35 described describe VBN cord-328289-3h3kmjlz 271 36 in in IN cord-328289-3h3kmjlz 271 37 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 271 38 ( ( -LRB- cord-328289-3h3kmjlz 271 39 Schulte Schulte NNP cord-328289-3h3kmjlz 271 40 - - HYPH cord-328289-3h3kmjlz 271 41 Schrepping Schrepping NNP cord-328289-3h3kmjlz 271 42 et et FW cord-328289-3h3kmjlz 271 43 al al NNP cord-328289-3h3kmjlz 271 44 . . NNP cord-328289-3h3kmjlz 271 45 , , , cord-328289-3h3kmjlz 271 46 2020 2020 CD cord-328289-3h3kmjlz 271 47 ) ) -RRB- cord-328289-3h3kmjlz 271 48 , , , cord-328289-3h3kmjlz 271 49 leading lead VBG cord-328289-3h3kmjlz 271 50 to to IN cord-328289-3h3kmjlz 271 51 immunosuppression immunosuppression NN cord-328289-3h3kmjlz 271 52 and and CC cord-328289-3h3kmjlz 271 53 lymphopenia lymphopenia NNP cord-328289-3h3kmjlz 271 54 . . . cord-328289-3h3kmjlz 272 1 In in IN cord-328289-3h3kmjlz 272 2 addition addition NN cord-328289-3h3kmjlz 272 3 , , , cord-328289-3h3kmjlz 272 4 release release NN cord-328289-3h3kmjlz 272 5 of of IN cord-328289-3h3kmjlz 272 6 calprotectin calprotectin NNS cord-328289-3h3kmjlz 272 7 and and CC cord-328289-3h3kmjlz 272 8 cytokines cytokine NNS cord-328289-3h3kmjlz 272 9 from from IN cord-328289-3h3kmjlz 272 10 damaged damaged JJ cord-328289-3h3kmjlz 272 11 lungs lung NNS cord-328289-3h3kmjlz 272 12 could could MD cord-328289-3h3kmjlz 272 13 also also RB cord-328289-3h3kmjlz 272 14 contribute contribute VB cord-328289-3h3kmjlz 272 15 to to IN cord-328289-3h3kmjlz 272 16 emergency emergency NN cord-328289-3h3kmjlz 272 17 myelopoiesis myelopoiesis NN cord-328289-3h3kmjlz 272 18 ( ( -LRB- cord-328289-3h3kmjlz 272 19 Silvin Silvin NNP cord-328289-3h3kmjlz 272 20 et et NNP cord-328289-3h3kmjlz 272 21 al al NNP cord-328289-3h3kmjlz 272 22 . . NNP cord-328289-3h3kmjlz 272 23 , , , cord-328289-3h3kmjlz 272 24 2020 2020 CD cord-328289-3h3kmjlz 272 25 ) ) -RRB- cord-328289-3h3kmjlz 272 26 . . . cord-328289-3h3kmjlz 273 1 J J NNP cord-328289-3h3kmjlz 273 2 o o NN cord-328289-3h3kmjlz 273 3 u u NN cord-328289-3h3kmjlz 273 4 r r NN cord-328289-3h3kmjlz 273 5 n n NN cord-328289-3h3kmjlz 273 6 a a DT cord-328289-3h3kmjlz 273 7 l l NN cord-328289-3h3kmjlz 273 8 P p NN cord-328289-3h3kmjlz 273 9 r r NN cord-328289-3h3kmjlz 273 10 e e NN cord-328289-3h3kmjlz 273 11 -p -p NN cord-328289-3h3kmjlz 274 1 r r NNP cord-328289-3h3kmjlz 274 2 o o NN cord-328289-3h3kmjlz 274 3 o o NN cord-328289-3h3kmjlz 274 4 f f NN cord-328289-3h3kmjlz 274 5 eTOC etoc NN cord-328289-3h3kmjlz 274 6 : : : cord-328289-3h3kmjlz 275 1 Iadecola Iadecola NNP cord-328289-3h3kmjlz 275 2 et et NNP cord-328289-3h3kmjlz 275 3 al al NNP cord-328289-3h3kmjlz 275 4 . . . cord-328289-3h3kmjlz 276 1 , , , cord-328289-3h3kmjlz 276 2 review review VB cord-328289-3h3kmjlz 276 3 and and CC cord-328289-3h3kmjlz 276 4 discuss discuss VB cord-328289-3h3kmjlz 276 5 the the DT cord-328289-3h3kmjlz 276 6 acute acute JJ cord-328289-3h3kmjlz 276 7 and and CC cord-328289-3h3kmjlz 276 8 chronic chronic JJ cord-328289-3h3kmjlz 276 9 neurological neurological JJ cord-328289-3h3kmjlz 276 10 consequences consequence NNS cord-328289-3h3kmjlz 276 11 of of IN cord-328289-3h3kmjlz 276 12 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 276 13 , , , cord-328289-3h3kmjlz 276 14 potential potential JJ cord-328289-3h3kmjlz 276 15 mechanisms mechanism NNS cord-328289-3h3kmjlz 276 16 for for IN cord-328289-3h3kmjlz 276 17 neuropathogenesis neuropathogenesis NN cord-328289-3h3kmjlz 276 18 and and CC cord-328289-3h3kmjlz 276 19 the the DT cord-328289-3h3kmjlz 276 20 outstanding outstanding JJ cord-328289-3h3kmjlz 276 21 questions question NNS cord-328289-3h3kmjlz 276 22 to to TO cord-328289-3h3kmjlz 276 23 minimize minimize VB cord-328289-3h3kmjlz 276 24 its -PRON- PRP$ cord-328289-3h3kmjlz 276 25 harmful harmful JJ cord-328289-3h3kmjlz 276 26 nervous nervous JJ cord-328289-3h3kmjlz 276 27 system system NN cord-328289-3h3kmjlz 276 28 involvement involvement NN cord-328289-3h3kmjlz 276 29 . . . cord-328289-3h3kmjlz 277 1 J J NNP cord-328289-3h3kmjlz 277 2 o o NN cord-328289-3h3kmjlz 277 3 u u NN cord-328289-3h3kmjlz 277 4 r r NN cord-328289-3h3kmjlz 277 5 n n NN cord-328289-3h3kmjlz 277 6 a a DT cord-328289-3h3kmjlz 277 7 l l NN cord-328289-3h3kmjlz 277 8 P p NN cord-328289-3h3kmjlz 277 9 r r NN cord-328289-3h3kmjlz 277 10 e e NN cord-328289-3h3kmjlz 277 11 -p -p NN cord-328289-3h3kmjlz 278 1 r r NN cord-328289-3h3kmjlz 278 2 o o NN cord-328289-3h3kmjlz 278 3 o o NN cord-328289-3h3kmjlz 278 4 f f NN cord-328289-3h3kmjlz 278 5 ACE2 ACE2 NNP cord-328289-3h3kmjlz 278 6 _SP cord-328289-3h3kmjlz 279 1 BSG BSG NNP cord-328289-3h3kmjlz 279 2 _SP cord-328289-3h3kmjlz 280 1 NRP1 NRP1 NNP cord-328289-3h3kmjlz 280 2 _SP cord-328289-3h3kmjlz 281 1 TMPRSS2 TMPRSS2 NNP cord-328289-3h3kmjlz 281 2 _SP cord-328289-3h3kmjlz 282 1 TMPRSS11A TMPRSS11A NNP cord-328289-3h3kmjlz 282 2 _SP cord-328289-3h3kmjlz 283 1 TMPRSS11B TMPRSS11B NNS cord-328289-3h3kmjlz 283 2 _SP cord-328289-3h3kmjlz 283 3 FURIN FURIN NNP cord-328289-3h3kmjlz 283 4 _SP cord-328289-3h3kmjlz 283 5 CTSB CTSB NNP cord-328289-3h3kmjlz 283 6 _SP cord-328289-3h3kmjlz 283 7 CTSL CTSL NNP cord-328289-3h3kmjlz 283 8 _SP cord-328289-3h3kmjlz 284 1 LY6E LY6E NNP cord-328289-3h3kmjlz 284 2 _SP cord-328289-3h3kmjlz 285 1 IFITM1 IFITM1 NNP cord-328289-3h3kmjlz 285 2 _SP cord-328289-3h3kmjlz 286 1 IFITM2 IFITM2 NNP cord-328289-3h3kmjlz 286 2 _SP cord-328289-3h3kmjlz 287 1 IFITM3 IFITM3 NNP cord-328289-3h3kmjlz 287 2 _SP cord-328289-3h3kmjlz 288 1 IFNAR1 IFNAR1 NNP cord-328289-3h3kmjlz 288 2 _SP cord-328289-3h3kmjlz 289 1 IFNAR2 IFNAR2 NNP cord-328289-3h3kmjlz 289 2 _SP cord-328289-3h3kmjlz 290 1 SARS SARS NNP cord-328289-3h3kmjlz 290 2 coronavirus coronavirus NN cord-328289-3h3kmjlz 290 3 spike spike NN cord-328289-3h3kmjlz 290 4 protein protein NN cord-328289-3h3kmjlz 290 5 - - HYPH cord-328289-3h3kmjlz 290 6 induced induce VBN cord-328289-3h3kmjlz 290 7 innate innate JJ cord-328289-3h3kmjlz 290 8 immune immune JJ cord-328289-3h3kmjlz 290 9 response response NN cord-328289-3h3kmjlz 290 10 occurs occur VBZ cord-328289-3h3kmjlz 290 11 via via IN cord-328289-3h3kmjlz 290 12 activation activation NN cord-328289-3h3kmjlz 290 13 of of IN cord-328289-3h3kmjlz 290 14 the the DT cord-328289-3h3kmjlz 290 15 NF NF NNP cord-328289-3h3kmjlz 290 16 - - HYPH cord-328289-3h3kmjlz 290 17 kappaB kappaB NNP cord-328289-3h3kmjlz 290 18 pathway pathway NN cord-328289-3h3kmjlz 290 19 in in IN cord-328289-3h3kmjlz 290 20 human human JJ cord-328289-3h3kmjlz 290 21 monocyte monocyte NNP cord-328289-3h3kmjlz 290 22 macrophages macrophage NNS cord-328289-3h3kmjlz 290 23 in in IN cord-328289-3h3kmjlz 290 24 vitro vitro FW cord-328289-3h3kmjlz 291 1 Axonal Axonal NNP cord-328289-3h3kmjlz 291 2 Transport Transport NNP cord-328289-3h3kmjlz 291 3 Enables enable VBZ cord-328289-3h3kmjlz 291 4 Neuron Neuron NNP cord-328289-3h3kmjlz 291 5 - - HYPH cord-328289-3h3kmjlz 291 6 to to IN cord-328289-3h3kmjlz 291 7 - - HYPH cord-328289-3h3kmjlz 291 8 Neuron Neuron NNP cord-328289-3h3kmjlz 291 9 Propagation Propagation NNP cord-328289-3h3kmjlz 291 10 of of IN cord-328289-3h3kmjlz 291 11 Human Human NNP cord-328289-3h3kmjlz 291 12 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 291 13 OC43 OC43 NNP cord-328289-3h3kmjlz 291 14 COVID-19-Associated COVID-19-Associated NNP cord-328289-3h3kmjlz 291 15 Encephalitis encephalitis RB cord-328289-3h3kmjlz 291 16 Mimicking mimic VBG cord-328289-3h3kmjlz 291 17 Glial glial JJ cord-328289-3h3kmjlz 291 18 Tumor tumor NN cord-328289-3h3kmjlz 291 19 Delirium delirium NN cord-328289-3h3kmjlz 291 20 in in IN cord-328289-3h3kmjlz 291 21 mechanically mechanically RB cord-328289-3h3kmjlz 291 22 ventilated ventilate VBN cord-328289-3h3kmjlz 291 23 patients patient NNS cord-328289-3h3kmjlz 291 24 : : : cord-328289-3h3kmjlz 291 25 validity validity NN cord-328289-3h3kmjlz 291 26 and and CC cord-328289-3h3kmjlz 291 27 reliability reliability NN cord-328289-3h3kmjlz 291 28 of of IN cord-328289-3h3kmjlz 291 29 the the DT cord-328289-3h3kmjlz 291 30 confusion confusion NN cord-328289-3h3kmjlz 291 31 assessment assessment NN cord-328289-3h3kmjlz 291 32 method method NN cord-328289-3h3kmjlz 291 33 for for IN cord-328289-3h3kmjlz 291 34 the the DT cord-328289-3h3kmjlz 291 35 intensive intensive JJ cord-328289-3h3kmjlz 291 36 care care NN cord-328289-3h3kmjlz 291 37 unit unit NN cord-328289-3h3kmjlz 291 38 ( ( -LRB- cord-328289-3h3kmjlz 291 39 CAM CAM NNP cord-328289-3h3kmjlz 291 40 - - HYPH cord-328289-3h3kmjlz 291 41 ICU ICU NNP cord-328289-3h3kmjlz 291 42 ) ) -RRB- cord-328289-3h3kmjlz 292 1 The the DT cord-328289-3h3kmjlz 292 2 movers mover NNS cord-328289-3h3kmjlz 292 3 and and CC cord-328289-3h3kmjlz 292 4 shapers shaper NNS cord-328289-3h3kmjlz 292 5 in in IN cord-328289-3h3kmjlz 292 6 immune immune JJ cord-328289-3h3kmjlz 292 7 privilege privilege NN cord-328289-3h3kmjlz 292 8 of of IN cord-328289-3h3kmjlz 292 9 the the DT cord-328289-3h3kmjlz 292 10 CNS CNS NNP cord-328289-3h3kmjlz 292 11 Neuroimmune Neuroimmune NNP cord-328289-3h3kmjlz 292 12 Axes Axes NNPS cord-328289-3h3kmjlz 292 13 of of IN cord-328289-3h3kmjlz 292 14 the the DT cord-328289-3h3kmjlz 292 15 Blood Blood NNP cord-328289-3h3kmjlz 292 16 - - HYPH cord-328289-3h3kmjlz 292 17 Brain Brain NNP cord-328289-3h3kmjlz 292 18 Barriers Barriers NNPS cord-328289-3h3kmjlz 292 19 and and CC cord-328289-3h3kmjlz 292 20 Blood blood NN cord-328289-3h3kmjlz 292 21 - - HYPH cord-328289-3h3kmjlz 292 22 Brain Brain NNP cord-328289-3h3kmjlz 292 23 Interfaces Interfaces NNPS cord-328289-3h3kmjlz 292 24 : : : cord-328289-3h3kmjlz 292 25 Bases basis NNS cord-328289-3h3kmjlz 292 26 for for IN cord-328289-3h3kmjlz 292 27 Physiological physiological JJ cord-328289-3h3kmjlz 292 28 Regulation Regulation NNP cord-328289-3h3kmjlz 292 29 , , , cord-328289-3h3kmjlz 292 30 Disease Disease NNP cord-328289-3h3kmjlz 292 31 States States NNP cord-328289-3h3kmjlz 292 32 , , , cord-328289-3h3kmjlz 292 33 and and CC cord-328289-3h3kmjlz 292 34 Pharmacological Pharmacological NNP cord-328289-3h3kmjlz 292 35 Interventions Interventions NNPS cord-328289-3h3kmjlz 292 36 Acute acute JJ cord-328289-3h3kmjlz 292 37 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 292 38 with with IN cord-328289-3h3kmjlz 292 39 elevated elevated JJ cord-328289-3h3kmjlz 292 40 CSF CSF NNP cord-328289-3h3kmjlz 292 41 inflammatory inflammatory JJ cord-328289-3h3kmjlz 292 42 markers marker NNS cord-328289-3h3kmjlz 292 43 as as IN cord-328289-3h3kmjlz 292 44 the the DT cord-328289-3h3kmjlz 292 45 initial initial JJ cord-328289-3h3kmjlz 292 46 presentation presentation NN cord-328289-3h3kmjlz 292 47 of of IN cord-328289-3h3kmjlz 292 48 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 292 49 SARS SARS NNP cord-328289-3h3kmjlz 292 50 , , , cord-328289-3h3kmjlz 292 51 MERS MERS NNP cord-328289-3h3kmjlz 292 52 and and CC cord-328289-3h3kmjlz 292 53 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 292 54 : : : cord-328289-3h3kmjlz 292 55 clinical clinical JJ cord-328289-3h3kmjlz 292 56 manifestations manifestation NNS cord-328289-3h3kmjlz 292 57 and and CC cord-328289-3h3kmjlz 292 58 organsystem organsystem NN cord-328289-3h3kmjlz 292 59 complications complication NNS cord-328289-3h3kmjlz 292 60 : : : cord-328289-3h3kmjlz 292 61 a a DT cord-328289-3h3kmjlz 292 62 mini mini JJ cord-328289-3h3kmjlz 292 63 review review NN cord-328289-3h3kmjlz 292 64 Endotheliopathy Endotheliopathy NNP cord-328289-3h3kmjlz 292 65 in in IN cord-328289-3h3kmjlz 292 66 COVID-19-associated covid-19-associated JJ cord-328289-3h3kmjlz 292 67 coagulopathy coagulopathy NN cord-328289-3h3kmjlz 292 68 : : : cord-328289-3h3kmjlz 292 69 evidence evidence NN cord-328289-3h3kmjlz 292 70 from from IN cord-328289-3h3kmjlz 292 71 a a DT cord-328289-3h3kmjlz 292 72 single single JJ cord-328289-3h3kmjlz 292 73 - - HYPH cord-328289-3h3kmjlz 292 74 centre centre NN cord-328289-3h3kmjlz 292 75 , , , cord-328289-3h3kmjlz 292 76 cross cross JJ cord-328289-3h3kmjlz 292 77 - - JJ cord-328289-3h3kmjlz 292 78 sectional sectional JJ cord-328289-3h3kmjlz 292 79 study study NN cord-328289-3h3kmjlz 292 80 Clinical Clinical NNP cord-328289-3h3kmjlz 292 81 Characteristics Characteristics NNPS cord-328289-3h3kmjlz 292 82 of of IN cord-328289-3h3kmjlz 292 83 Covid-19 covid-19 NN cord-328289-3h3kmjlz 292 84 in in IN cord-328289-3h3kmjlz 292 85 Baseline Baseline NNP cord-328289-3h3kmjlz 292 86 Characteristics Characteristics NNP cord-328289-3h3kmjlz 292 87 and and CC cord-328289-3h3kmjlz 292 88 Outcomes Outcomes NNPS cord-328289-3h3kmjlz 292 89 of of IN cord-328289-3h3kmjlz 292 90 1591 1591 CD cord-328289-3h3kmjlz 292 91 Patients patient NNS cord-328289-3h3kmjlz 292 92 Infected infect VBN cord-328289-3h3kmjlz 292 93 With with IN cord-328289-3h3kmjlz 292 94 SARS SARS NNP cord-328289-3h3kmjlz 292 95 - - HYPH cord-328289-3h3kmjlz 292 96 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 293 1 Admitted admit VBN cord-328289-3h3kmjlz 293 2 to to IN cord-328289-3h3kmjlz 293 3 ICUs ICUs NNP cord-328289-3h3kmjlz 293 4 of of IN cord-328289-3h3kmjlz 293 5 the the DT cord-328289-3h3kmjlz 293 6 Lombardy Lombardy NNP cord-328289-3h3kmjlz 293 7 Region Region NNP cord-328289-3h3kmjlz 293 8 Miller Miller NNP cord-328289-3h3kmjlz 293 9 Fisher Fisher NNP cord-328289-3h3kmjlz 293 10 syndrome syndrome NN cord-328289-3h3kmjlz 293 11 and and CC cord-328289-3h3kmjlz 293 12 polyneuritis polyneuritis NNP cord-328289-3h3kmjlz 293 13 cranialis cranialis NNP cord-328289-3h3kmjlz 293 14 in in IN cord-328289-3h3kmjlz 293 15 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 293 16 Interferon Interferon NNP cord-328289-3h3kmjlz 293 17 - - HYPH cord-328289-3h3kmjlz 293 18 Induced induce VBN cord-328289-3h3kmjlz 293 19 Transmembrane Transmembrane NNP cord-328289-3h3kmjlz 293 20 Protein Protein NNP cord-328289-3h3kmjlz 293 21 ( ( -LRB- cord-328289-3h3kmjlz 293 22 IFITM3 IFITM3 NNP cord-328289-3h3kmjlz 293 23 ) ) -RRB- cord-328289-3h3kmjlz 293 24 Is be VBZ cord-328289-3h3kmjlz 293 25 Upregulated Upregulated NNP cord-328289-3h3kmjlz 293 26 Explicitly explicitly RB cord-328289-3h3kmjlz 293 27 in in IN cord-328289-3h3kmjlz 293 28 SARS SARS NNP cord-328289-3h3kmjlz 293 29 - - HYPH cord-328289-3h3kmjlz 293 30 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 294 1 Infected infected JJ cord-328289-3h3kmjlz 294 2 Lung Lung NNP cord-328289-3h3kmjlz 294 3 Epithelial epithelial NN cord-328289-3h3kmjlz 294 4 Cells cell NNS cord-328289-3h3kmjlz 294 5 Tissue tissue NN cord-328289-3h3kmjlz 294 6 distribution distribution NN cord-328289-3h3kmjlz 294 7 of of IN cord-328289-3h3kmjlz 294 8 ACE2 ACE2 NNP cord-328289-3h3kmjlz 294 9 protein protein NN cord-328289-3h3kmjlz 294 10 , , , cord-328289-3h3kmjlz 294 11 the the DT cord-328289-3h3kmjlz 294 12 functional functional JJ cord-328289-3h3kmjlz 294 13 receptor receptor NN cord-328289-3h3kmjlz 294 14 for for IN cord-328289-3h3kmjlz 294 15 SARS SARS NNP cord-328289-3h3kmjlz 294 16 coronavirus coronavirus NN cord-328289-3h3kmjlz 294 17 . . . cord-328289-3h3kmjlz 295 1 A a DT cord-328289-3h3kmjlz 295 2 first first JJ cord-328289-3h3kmjlz 295 3 step step NN cord-328289-3h3kmjlz 295 4 in in IN cord-328289-3h3kmjlz 295 5 understanding understand VBG cord-328289-3h3kmjlz 295 6 SARS SARS NNP cord-328289-3h3kmjlz 295 7 pathogenesis pathogenesis NN cord-328289-3h3kmjlz 295 8 Proteomic Proteomic NNP cord-328289-3h3kmjlz 295 9 analysis analysis NN cord-328289-3h3kmjlz 295 10 of of IN cord-328289-3h3kmjlz 295 11 active active JJ cord-328289-3h3kmjlz 295 12 multiple multiple JJ cord-328289-3h3kmjlz 295 13 sclerosis sclerosis NN cord-328289-3h3kmjlz 295 14 lesions lesion NNS cord-328289-3h3kmjlz 295 15 reveals reveal VBZ cord-328289-3h3kmjlz 295 16 therapeutic therapeutic JJ cord-328289-3h3kmjlz 295 17 targets target NNS cord-328289-3h3kmjlz 295 18 Effect effect NN cord-328289-3h3kmjlz 295 19 of of IN cord-328289-3h3kmjlz 295 20 Dexamethasone Dexamethasone NNP cord-328289-3h3kmjlz 295 21 in in IN cord-328289-3h3kmjlz 295 22 Hospitalized Hospitalized NNP cord-328289-3h3kmjlz 295 23 Patients Patients NNP cord-328289-3h3kmjlz 295 24 with with IN cord-328289-3h3kmjlz 295 25 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 295 26 -Preliminary -Preliminary NNP cord-328289-3h3kmjlz 295 27 Pericyte Pericyte NNP cord-328289-3h3kmjlz 295 28 - - HYPH cord-328289-3h3kmjlz 295 29 specific specific JJ cord-328289-3h3kmjlz 295 30 vascular vascular JJ cord-328289-3h3kmjlz 295 31 expression expression NN cord-328289-3h3kmjlz 295 32 of of IN cord-328289-3h3kmjlz 295 33 SARS SARS NNP cord-328289-3h3kmjlz 295 34 - - HYPH cord-328289-3h3kmjlz 295 35 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 295 36 receptor receptor NN cord-328289-3h3kmjlz 295 37 ACE2-implications ace2-implication NNS cord-328289-3h3kmjlz 295 38 for for IN cord-328289-3h3kmjlz 295 39 microvascular microvascular JJ cord-328289-3h3kmjlz 295 40 inflammation inflammation NN cord-328289-3h3kmjlz 295 41 Neurologic neurologic NN cord-328289-3h3kmjlz 295 42 Features Features NNPS cord-328289-3h3kmjlz 295 43 in in IN cord-328289-3h3kmjlz 295 44 Severe severe JJ cord-328289-3h3kmjlz 295 45 SARS SARS NNP cord-328289-3h3kmjlz 295 46 - - HYPH cord-328289-3h3kmjlz 295 47 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 295 48 Infection Infection NNP cord-328289-3h3kmjlz 295 49 High high JJ cord-328289-3h3kmjlz 295 50 risk risk NN cord-328289-3h3kmjlz 295 51 of of IN cord-328289-3h3kmjlz 295 52 thrombosis thrombosis NN cord-328289-3h3kmjlz 295 53 in in IN cord-328289-3h3kmjlz 295 54 patients patient NNS cord-328289-3h3kmjlz 295 55 with with IN cord-328289-3h3kmjlz 295 56 severe severe JJ cord-328289-3h3kmjlz 295 57 SARS SARS NNP cord-328289-3h3kmjlz 295 58 - - HYPH cord-328289-3h3kmjlz 295 59 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 295 60 infection infection NN cord-328289-3h3kmjlz 295 61 : : : cord-328289-3h3kmjlz 296 1 a a DT cord-328289-3h3kmjlz 296 2 multicenter multicenter JJ cord-328289-3h3kmjlz 296 3 prospective prospective JJ cord-328289-3h3kmjlz 296 4 cohort cohort NN cord-328289-3h3kmjlz 296 5 study study NN cord-328289-3h3kmjlz 296 6 Conserved conserved JJ cord-328289-3h3kmjlz 296 7 cell cell NN cord-328289-3h3kmjlz 296 8 types type NNS cord-328289-3h3kmjlz 296 9 with with IN cord-328289-3h3kmjlz 296 10 divergent divergent JJ cord-328289-3h3kmjlz 296 11 features feature NNS cord-328289-3h3kmjlz 296 12 in in IN cord-328289-3h3kmjlz 296 13 human human NN cord-328289-3h3kmjlz 296 14 versus versus IN cord-328289-3h3kmjlz 296 15 mouse mouse NN cord-328289-3h3kmjlz 296 16 cortex cortex NNP cord-328289-3h3kmjlz 296 17 SARS SARS NNP cord-328289-3h3kmjlz 296 18 - - HYPH cord-328289-3h3kmjlz 296 19 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 296 20 Cell Cell NNP cord-328289-3h3kmjlz 296 21 Entry entry NN cord-328289-3h3kmjlz 296 22 Depends depend VBZ cord-328289-3h3kmjlz 296 23 on on IN cord-328289-3h3kmjlz 296 24 ACE2 ACE2 NNP cord-328289-3h3kmjlz 296 25 and and CC cord-328289-3h3kmjlz 296 26 TMPRSS2 TMPRSS2 NNP cord-328289-3h3kmjlz 296 27 and and CC cord-328289-3h3kmjlz 296 28 Is be VBZ cord-328289-3h3kmjlz 296 29 Blocked block VBN cord-328289-3h3kmjlz 296 30 by by IN cord-328289-3h3kmjlz 296 31 a a DT cord-328289-3h3kmjlz 296 32 Clinically clinically RB cord-328289-3h3kmjlz 296 33 Proven prove VBN cord-328289-3h3kmjlz 296 34 Protease protease NN cord-328289-3h3kmjlz 296 35 Inhibitor Inhibitor NNP cord-328289-3h3kmjlz 296 36 Two two CD cord-328289-3h3kmjlz 296 37 - - HYPH cord-328289-3h3kmjlz 296 38 year year NN cord-328289-3h3kmjlz 296 39 cognitive cognitive JJ cord-328289-3h3kmjlz 296 40 , , , cord-328289-3h3kmjlz 296 41 emotional emotional JJ cord-328289-3h3kmjlz 296 42 , , , cord-328289-3h3kmjlz 296 43 and and CC cord-328289-3h3kmjlz 296 44 quality quality NN cord-328289-3h3kmjlz 296 45 - - HYPH cord-328289-3h3kmjlz 296 46 of of IN cord-328289-3h3kmjlz 296 47 - - HYPH cord-328289-3h3kmjlz 296 48 life life NN cord-328289-3h3kmjlz 296 49 outcomes outcome NNS cord-328289-3h3kmjlz 296 50 in in IN cord-328289-3h3kmjlz 296 51 acute acute JJ cord-328289-3h3kmjlz 296 52 respiratory respiratory JJ cord-328289-3h3kmjlz 296 53 distress distress NN cord-328289-3h3kmjlz 296 54 syndrome syndrome NN cord-328289-3h3kmjlz 296 55 Clinical clinical JJ cord-328289-3h3kmjlz 296 56 features feature NNS cord-328289-3h3kmjlz 296 57 of of IN cord-328289-3h3kmjlz 296 58 patients patient NNS cord-328289-3h3kmjlz 296 59 infected infect VBN cord-328289-3h3kmjlz 296 60 with with IN cord-328289-3h3kmjlz 296 61 2019 2019 CD cord-328289-3h3kmjlz 296 62 novel novel JJ cord-328289-3h3kmjlz 296 63 coronavirus coronavirus NN cord-328289-3h3kmjlz 296 64 in in IN cord-328289-3h3kmjlz 296 65 Wuhan Wuhan NNP cord-328289-3h3kmjlz 296 66 SARS SARS NNP cord-328289-3h3kmjlz 296 67 - - HYPH cord-328289-3h3kmjlz 296 68 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 297 1 Detected detect VBN cord-328289-3h3kmjlz 297 2 in in IN cord-328289-3h3kmjlz 297 3 Cerebrospinal Cerebrospinal NNP cord-328289-3h3kmjlz 297 4 Fluid Fluid NNP cord-328289-3h3kmjlz 297 5 by by IN cord-328289-3h3kmjlz 297 6 PCR PCR NNP cord-328289-3h3kmjlz 297 7 in in IN cord-328289-3h3kmjlz 297 8 a a DT cord-328289-3h3kmjlz 297 9 Case Case NNP cord-328289-3h3kmjlz 297 10 of of IN cord-328289-3h3kmjlz 297 11 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 297 12 Encephalitis Encephalitis NNP cord-328289-3h3kmjlz 297 13 Immune Immune NNP cord-328289-3h3kmjlz 297 14 responses response NNS cord-328289-3h3kmjlz 297 15 to to IN cord-328289-3h3kmjlz 297 16 stroke stroke VB cord-328289-3h3kmjlz 297 17 : : : cord-328289-3h3kmjlz 297 18 mechanisms mechanism NNS cord-328289-3h3kmjlz 297 19 , , , cord-328289-3h3kmjlz 297 20 modulation modulation NN cord-328289-3h3kmjlz 297 21 , , , cord-328289-3h3kmjlz 297 22 and and CC cord-328289-3h3kmjlz 297 23 therapeutic therapeutic JJ cord-328289-3h3kmjlz 297 24 potential potential JJ cord-328289-3h3kmjlz 297 25 Characteristics characteristic NNS cord-328289-3h3kmjlz 297 26 and and CC cord-328289-3h3kmjlz 297 27 outcomes outcome NNS cord-328289-3h3kmjlz 297 28 of of IN cord-328289-3h3kmjlz 297 29 patients patient NNS cord-328289-3h3kmjlz 297 30 hospitalized hospitalize VBN cord-328289-3h3kmjlz 297 31 for for IN cord-328289-3h3kmjlz 297 32 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 297 33 and and CC cord-328289-3h3kmjlz 297 34 cardiac cardiac JJ cord-328289-3h3kmjlz 297 35 disease disease NN cord-328289-3h3kmjlz 297 36 in in IN cord-328289-3h3kmjlz 298 1 Northern Northern NNP cord-328289-3h3kmjlz 298 2 Italy Italy NNP cord-328289-3h3kmjlz 298 3 NLRP3 nlrp3 NN cord-328289-3h3kmjlz 298 4 inflammasome inflammasome NNP cord-328289-3h3kmjlz 298 5 activation activation NN cord-328289-3h3kmjlz 298 6 drives drive VBZ cord-328289-3h3kmjlz 298 7 tau tau NNP cord-328289-3h3kmjlz 298 8 pathology pathology NNP cord-328289-3h3kmjlz 298 9 Long long JJ cord-328289-3h3kmjlz 298 10 - - HYPH cord-328289-3h3kmjlz 298 11 term term NN cord-328289-3h3kmjlz 298 12 cognitive cognitive JJ cord-328289-3h3kmjlz 298 13 impairment impairment NN cord-328289-3h3kmjlz 298 14 and and CC cord-328289-3h3kmjlz 298 15 functional functional JJ cord-328289-3h3kmjlz 298 16 disability disability NN cord-328289-3h3kmjlz 298 17 among among IN cord-328289-3h3kmjlz 298 18 survivors survivor NNS cord-328289-3h3kmjlz 298 19 of of IN cord-328289-3h3kmjlz 298 20 severe severe JJ cord-328289-3h3kmjlz 298 21 sepsis sepsis NN cord-328289-3h3kmjlz 298 22 Brain Brain NNP cord-328289-3h3kmjlz 298 23 MRI MRI NNP cord-328289-3h3kmjlz 298 24 Findings Findings NNP cord-328289-3h3kmjlz 298 25 in in IN cord-328289-3h3kmjlz 298 26 Patients patient NNS cord-328289-3h3kmjlz 298 27 in in IN cord-328289-3h3kmjlz 298 28 the the DT cord-328289-3h3kmjlz 298 29 Intensive Intensive NNP cord-328289-3h3kmjlz 298 30 Care Care NNP cord-328289-3h3kmjlz 298 31 Unit Unit NNP cord-328289-3h3kmjlz 298 32 with with IN cord-328289-3h3kmjlz 298 33 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 298 34 Infection Infection NNP cord-328289-3h3kmjlz 298 35 . . . cord-328289-3h3kmjlz 299 1 Radiology Radiology NNP cord-328289-3h3kmjlz 299 2 Neuropathologic Neuropathologic NNP cord-328289-3h3kmjlz 299 3 features feature NNS cord-328289-3h3kmjlz 299 4 of of IN cord-328289-3h3kmjlz 299 5 four four CD cord-328289-3h3kmjlz 299 6 autopsied autopsie VBN cord-328289-3h3kmjlz 299 7 COVID-19 covid-19 CD cord-328289-3h3kmjlz 299 8 patients patient NNS cord-328289-3h3kmjlz 300 1 The the DT cord-328289-3h3kmjlz 300 2 circumventricular circumventricular JJ cord-328289-3h3kmjlz 300 3 organs organ NNS cord-328289-3h3kmjlz 301 1 The the DT cord-328289-3h3kmjlz 301 2 search search NN cord-328289-3h3kmjlz 301 3 for for IN cord-328289-3h3kmjlz 301 4 a a DT cord-328289-3h3kmjlz 301 5 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 301 6 animal animal NN cord-328289-3h3kmjlz 301 7 model model NN cord-328289-3h3kmjlz 301 8 Integrative Integrative NNP cord-328289-3h3kmjlz 301 9 single single JJ cord-328289-3h3kmjlz 301 10 - - HYPH cord-328289-3h3kmjlz 301 11 cell cell NN cord-328289-3h3kmjlz 301 12 analysis analysis NN cord-328289-3h3kmjlz 301 13 of of IN cord-328289-3h3kmjlz 301 14 transcriptional transcriptional JJ cord-328289-3h3kmjlz 301 15 and and CC cord-328289-3h3kmjlz 301 16 epigenetic epigenetic JJ cord-328289-3h3kmjlz 301 17 states state NNS cord-328289-3h3kmjlz 301 18 in in IN cord-328289-3h3kmjlz 301 19 the the DT cord-328289-3h3kmjlz 301 20 human human JJ cord-328289-3h3kmjlz 301 21 adult adult NN cord-328289-3h3kmjlz 301 22 brain brain NN cord-328289-3h3kmjlz 302 1 The the DT cord-328289-3h3kmjlz 302 2 neuroinvasive neuroinvasive JJ cord-328289-3h3kmjlz 302 3 potential potential NN cord-328289-3h3kmjlz 302 4 of of IN cord-328289-3h3kmjlz 302 5 SARS SARS NNP cord-328289-3h3kmjlz 302 6 - - HYPH cord-328289-3h3kmjlz 302 7 CoV2 CoV2 NNP cord-328289-3h3kmjlz 302 8 may may MD cord-328289-3h3kmjlz 302 9 play play VB cord-328289-3h3kmjlz 302 10 a a DT cord-328289-3h3kmjlz 302 11 role role NN cord-328289-3h3kmjlz 302 12 in in IN cord-328289-3h3kmjlz 302 13 the the DT cord-328289-3h3kmjlz 302 14 respiratory respiratory JJ cord-328289-3h3kmjlz 302 15 failure failure NN cord-328289-3h3kmjlz 302 16 of of IN cord-328289-3h3kmjlz 302 17 COVID-19 covid-19 JJ cord-328289-3h3kmjlz 302 18 patients patient NNS cord-328289-3h3kmjlz 302 19 Infectious Infectious NNP cord-328289-3h3kmjlz 302 20 Etiologies Etiologies NNPS cord-328289-3h3kmjlz 302 21 of of IN cord-328289-3h3kmjlz 302 22 Parkinsonism Parkinsonism NNP cord-328289-3h3kmjlz 302 23 : : : cord-328289-3h3kmjlz 303 1 Pathomechanisms Pathomechanisms NNP cord-328289-3h3kmjlz 303 2 and and CC cord-328289-3h3kmjlz 303 3 Clinical Clinical NNP cord-328289-3h3kmjlz 303 4 Implications Implications NNPS cord-328289-3h3kmjlz 303 5 Clinical clinical JJ cord-328289-3h3kmjlz 303 6 and and CC cord-328289-3h3kmjlz 303 7 biochemical biochemical JJ cord-328289-3h3kmjlz 303 8 indexes index NNS cord-328289-3h3kmjlz 303 9 from from IN cord-328289-3h3kmjlz 303 10 2019-nCoV 2019-ncov CD cord-328289-3h3kmjlz 303 11 infected infect VBN cord-328289-3h3kmjlz 303 12 patients patient NNS cord-328289-3h3kmjlz 303 13 linked link VBN cord-328289-3h3kmjlz 303 14 to to IN cord-328289-3h3kmjlz 303 15 viral viral JJ cord-328289-3h3kmjlz 303 16 loads load NNS cord-328289-3h3kmjlz 303 17 and and CC cord-328289-3h3kmjlz 303 18 lung lung NN cord-328289-3h3kmjlz 303 19 injury injury NN cord-328289-3h3kmjlz 303 20 Venous venous JJ cord-328289-3h3kmjlz 303 21 and and CC cord-328289-3h3kmjlz 303 22 arterial arterial JJ cord-328289-3h3kmjlz 303 23 thromboembolic thromboembolic JJ cord-328289-3h3kmjlz 303 24 complications complication NNS cord-328289-3h3kmjlz 303 25 in in IN cord-328289-3h3kmjlz 303 26 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 303 27 patients patient NNS cord-328289-3h3kmjlz 303 28 admitted admit VBD cord-328289-3h3kmjlz 303 29 to to IN cord-328289-3h3kmjlz 303 30 an an DT cord-328289-3h3kmjlz 303 31 academic academic JJ cord-328289-3h3kmjlz 303 32 hospital hospital NN cord-328289-3h3kmjlz 303 33 in in IN cord-328289-3h3kmjlz 303 34 Critical Critical NNP cord-328289-3h3kmjlz 303 35 Medical Medical NNP cord-328289-3h3kmjlz 303 36 Illness Illness NNP cord-328289-3h3kmjlz 303 37 and and CC cord-328289-3h3kmjlz 303 38 the the DT cord-328289-3h3kmjlz 303 39 Nervous Nervous NNP cord-328289-3h3kmjlz 303 40 System System NNP cord-328289-3h3kmjlz 303 41 Neurologic Neurologic NNP cord-328289-3h3kmjlz 303 42 Manifestations manifestation NNS cord-328289-3h3kmjlz 303 43 of of IN cord-328289-3h3kmjlz 303 44 Hospitalized Hospitalized NNP cord-328289-3h3kmjlz 303 45 Patients Patients NNP cord-328289-3h3kmjlz 303 46 With with IN cord-328289-3h3kmjlz 303 47 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 303 48 Disease Disease NNP cord-328289-3h3kmjlz 303 49 Pathological pathological JJ cord-328289-3h3kmjlz 303 50 inflammation inflammation NN cord-328289-3h3kmjlz 303 51 in in IN cord-328289-3h3kmjlz 303 52 patients patient NNS cord-328289-3h3kmjlz 303 53 with with IN cord-328289-3h3kmjlz 303 54 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 303 55 : : : cord-328289-3h3kmjlz 303 56 a a DT cord-328289-3h3kmjlz 303 57 key key JJ cord-328289-3h3kmjlz 303 58 role role NN cord-328289-3h3kmjlz 303 59 for for IN cord-328289-3h3kmjlz 303 60 monocytes monocyte NNS cord-328289-3h3kmjlz 303 61 and and CC cord-328289-3h3kmjlz 303 62 macrophages macrophage NNS cord-328289-3h3kmjlz 303 63 Risk risk NN cord-328289-3h3kmjlz 303 64 of of IN cord-328289-3h3kmjlz 303 65 Ischemic Ischemic NNP cord-328289-3h3kmjlz 303 66 Stroke Stroke NNP cord-328289-3h3kmjlz 303 67 in in IN cord-328289-3h3kmjlz 303 68 Patients Patients NNP cord-328289-3h3kmjlz 303 69 With with IN cord-328289-3h3kmjlz 303 70 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 303 71 Disease Disease NNP cord-328289-3h3kmjlz 303 72 2019 2019 CD cord-328289-3h3kmjlz 303 73 ( ( -LRB- cord-328289-3h3kmjlz 303 74 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 303 75 ) ) -RRB- cord-328289-3h3kmjlz 303 76 vs vs IN cord-328289-3h3kmjlz 303 77 Patients patient NNS cord-328289-3h3kmjlz 303 78 With with IN cord-328289-3h3kmjlz 304 1 Influenza Influenza NNP cord-328289-3h3kmjlz 304 2 Neutrophil Neutrophil NNP cord-328289-3h3kmjlz 304 3 Extracellular Extracellular NNP cord-328289-3h3kmjlz 304 4 Traps trap NNS cord-328289-3h3kmjlz 304 5 ( ( -LRB- cord-328289-3h3kmjlz 304 6 NETs net NNS cord-328289-3h3kmjlz 304 7 ) ) -RRB- cord-328289-3h3kmjlz 304 8 Contribute contribute VB cord-328289-3h3kmjlz 304 9 to to IN cord-328289-3h3kmjlz 304 10 Immunothrombosis Immunothrombosis NNP cord-328289-3h3kmjlz 304 11 in in IN cord-328289-3h3kmjlz 304 12 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 304 13 Acute Acute NNP cord-328289-3h3kmjlz 304 14 Respiratory Respiratory NNP cord-328289-3h3kmjlz 304 15 Distress Distress NNP cord-328289-3h3kmjlz 304 16 Syndrome Syndrome NNP cord-328289-3h3kmjlz 305 1 A a DT cord-328289-3h3kmjlz 305 2 first first JJ cord-328289-3h3kmjlz 305 3 case case NN cord-328289-3h3kmjlz 305 4 of of IN cord-328289-3h3kmjlz 305 5 meningitis meningitis NN cord-328289-3h3kmjlz 305 6 / / SYM cord-328289-3h3kmjlz 305 7 encephalitis encephalitis NN cord-328289-3h3kmjlz 305 8 associated associate VBN cord-328289-3h3kmjlz 305 9 with with IN cord-328289-3h3kmjlz 305 10 SARS SARS NNP cord-328289-3h3kmjlz 305 11 - - HYPH cord-328289-3h3kmjlz 305 12 Coronavirus-2 Coronavirus-2 NNP cord-328289-3h3kmjlz 306 1 The the DT cord-328289-3h3kmjlz 306 2 hypothalamus hypothalamus NN cord-328289-3h3kmjlz 306 3 as as IN cord-328289-3h3kmjlz 306 4 a a DT cord-328289-3h3kmjlz 306 5 hub hub NN cord-328289-3h3kmjlz 306 6 for for IN cord-328289-3h3kmjlz 306 7 SARS SARS NNP cord-328289-3h3kmjlz 306 8 - - HYPH cord-328289-3h3kmjlz 306 9 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 306 10 brain brain NN cord-328289-3h3kmjlz 306 11 infection infection NN cord-328289-3h3kmjlz 306 12 and and CC cord-328289-3h3kmjlz 306 13 pathogenesis pathogenesis NN cord-328289-3h3kmjlz 306 14 Incidence incidence NN cord-328289-3h3kmjlz 306 15 , , , cord-328289-3h3kmjlz 306 16 risk risk NN cord-328289-3h3kmjlz 306 17 factors factor NNS cord-328289-3h3kmjlz 306 18 and and CC cord-328289-3h3kmjlz 306 19 consequences consequence NNS cord-328289-3h3kmjlz 306 20 of of IN cord-328289-3h3kmjlz 306 21 ICU ICU NNP cord-328289-3h3kmjlz 306 22 delirium delirium NN cord-328289-3h3kmjlz 306 23 Large large JJ cord-328289-3h3kmjlz 306 24 - - HYPH cord-328289-3h3kmjlz 306 25 Vessel Vessel NNP cord-328289-3h3kmjlz 306 26 Stroke Stroke NNP cord-328289-3h3kmjlz 306 27 as as IN cord-328289-3h3kmjlz 306 28 a a DT cord-328289-3h3kmjlz 306 29 Presenting Presenting NNP cord-328289-3h3kmjlz 306 30 Feature feature NN cord-328289-3h3kmjlz 306 31 of of IN cord-328289-3h3kmjlz 306 32 Covid-19 covid-19 NN cord-328289-3h3kmjlz 306 33 in in IN cord-328289-3h3kmjlz 306 34 the the DT cord-328289-3h3kmjlz 306 35 Young Young NNP cord-328289-3h3kmjlz 307 1 COVID-19 covid-19 VB cord-328289-3h3kmjlz 307 2 and and CC cord-328289-3h3kmjlz 307 3 the the DT cord-328289-3h3kmjlz 307 4 endocrine endocrine NN cord-328289-3h3kmjlz 307 5 system system NN cord-328289-3h3kmjlz 307 6 : : : cord-328289-3h3kmjlz 307 7 exploring explore VBG cord-328289-3h3kmjlz 307 8 the the DT cord-328289-3h3kmjlz 307 9 unexplored unexplored JJ cord-328289-3h3kmjlz 307 10 Clinical Clinical NNP cord-328289-3h3kmjlz 307 11 Characteristics characteristic NNS cord-328289-3h3kmjlz 307 12 of of IN cord-328289-3h3kmjlz 307 13 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 307 14 Patients Patients NNPS cord-328289-3h3kmjlz 307 15 With with IN cord-328289-3h3kmjlz 307 16 Digestive digestive JJ cord-328289-3h3kmjlz 307 17 Symptoms symptom NNS cord-328289-3h3kmjlz 307 18 in in IN cord-328289-3h3kmjlz 307 19 Hubei Hubei NNP cord-328289-3h3kmjlz 307 20 , , , cord-328289-3h3kmjlz 307 21 China China NNP cord-328289-3h3kmjlz 307 22 : : : cord-328289-3h3kmjlz 307 23 A a DT cord-328289-3h3kmjlz 307 24 Descriptive descriptive JJ cord-328289-3h3kmjlz 307 25 , , , cord-328289-3h3kmjlz 307 26 Cross Cross NNP cord-328289-3h3kmjlz 307 27 - - HYPH cord-328289-3h3kmjlz 307 28 Sectional Sectional NNP cord-328289-3h3kmjlz 307 29 , , , cord-328289-3h3kmjlz 307 30 Multicenter Multicenter NNP cord-328289-3h3kmjlz 307 31 Study Study NNP cord-328289-3h3kmjlz 307 32 Lymphopenia Lymphopenia NNP cord-328289-3h3kmjlz 307 33 and and CC cord-328289-3h3kmjlz 307 34 neutrophilia neutrophilia NNP cord-328289-3h3kmjlz 307 35 in in IN cord-328289-3h3kmjlz 307 36 SARS SARS NNP cord-328289-3h3kmjlz 307 37 are be VBP cord-328289-3h3kmjlz 307 38 related relate VBN cord-328289-3h3kmjlz 307 39 to to IN cord-328289-3h3kmjlz 307 40 the the DT cord-328289-3h3kmjlz 307 41 prevailing prevail VBG cord-328289-3h3kmjlz 307 42 serum serum NN cord-328289-3h3kmjlz 307 43 cortisol cortisol NN cord-328289-3h3kmjlz 307 44 Central central JJ cord-328289-3h3kmjlz 307 45 nervous nervous JJ cord-328289-3h3kmjlz 307 46 system system NN cord-328289-3h3kmjlz 307 47 involvement involvement NN cord-328289-3h3kmjlz 307 48 by by IN cord-328289-3h3kmjlz 307 49 severe severe JJ cord-328289-3h3kmjlz 307 50 acute acute JJ cord-328289-3h3kmjlz 307 51 respiratory respiratory JJ cord-328289-3h3kmjlz 307 52 syndrome syndrome NN cord-328289-3h3kmjlz 307 53 coronavirus-2 coronavirus-2 NN cord-328289-3h3kmjlz 308 1 ( ( -LRB- cord-328289-3h3kmjlz 308 2 SARS SARS NNP cord-328289-3h3kmjlz 308 3 - - HYPH cord-328289-3h3kmjlz 308 4 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 308 5 ) ) -RRB- cord-328289-3h3kmjlz 308 6 Association Association NNP cord-328289-3h3kmjlz 308 7 of of IN cord-328289-3h3kmjlz 308 8 Treatment Treatment NNP cord-328289-3h3kmjlz 308 9 Dose Dose NNP cord-328289-3h3kmjlz 308 10 Anticoagulation Anticoagulation NNP cord-328289-3h3kmjlz 308 11 With with IN cord-328289-3h3kmjlz 308 12 In in IN cord-328289-3h3kmjlz 308 13 - - HYPH cord-328289-3h3kmjlz 308 14 Hospital Hospital NNP cord-328289-3h3kmjlz 308 15 Survival survival NN cord-328289-3h3kmjlz 308 16 Among among IN cord-328289-3h3kmjlz 308 17 Hospitalized hospitalize VBN cord-328289-3h3kmjlz 308 18 Patients patient NNS cord-328289-3h3kmjlz 308 19 With with IN cord-328289-3h3kmjlz 309 1 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 309 2 Inflammation Inflammation NNP cord-328289-3h3kmjlz 309 3 , , , cord-328289-3h3kmjlz 309 4 Autoimmunity Autoimmunity NNP cord-328289-3h3kmjlz 309 5 , , , cord-328289-3h3kmjlz 309 6 Infection infection NN cord-328289-3h3kmjlz 309 7 , , , cord-328289-3h3kmjlz 309 8 and and CC cord-328289-3h3kmjlz 309 9 Stroke stroke NN cord-328289-3h3kmjlz 309 10 : : : cord-328289-3h3kmjlz 309 11 Epidemiology Epidemiology NNP cord-328289-3h3kmjlz 309 12 and and CC cord-328289-3h3kmjlz 309 13 Lessons Lessons NNPS cord-328289-3h3kmjlz 309 14 From from IN cord-328289-3h3kmjlz 309 15 Therapeutic therapeutic JJ cord-328289-3h3kmjlz 309 16 Intervention Intervention NNP cord-328289-3h3kmjlz 309 17 COVID-19-associated covid-19-associated JJ cord-328289-3h3kmjlz 309 18 acute acute JJ cord-328289-3h3kmjlz 309 19 disseminated disseminate VBN cord-328289-3h3kmjlz 309 20 encephalomyelitis encephalomyelitis NN cord-328289-3h3kmjlz 309 21 ( ( -LRB- cord-328289-3h3kmjlz 309 22 ADEM ADEM NNP cord-328289-3h3kmjlz 309 23 ) ) -RRB- cord-328289-3h3kmjlz 310 1 LY6E LY6E NNP cord-328289-3h3kmjlz 310 2 impairs impair VBZ cord-328289-3h3kmjlz 310 3 coronavirus coronavirus NN cord-328289-3h3kmjlz 310 4 fusion fusion NN cord-328289-3h3kmjlz 310 5 and and CC cord-328289-3h3kmjlz 310 6 confers confer VBZ cord-328289-3h3kmjlz 310 7 immune immune JJ cord-328289-3h3kmjlz 310 8 control control NN cord-328289-3h3kmjlz 310 9 of of IN cord-328289-3h3kmjlz 310 10 viral viral JJ cord-328289-3h3kmjlz 310 11 disease disease NN cord-328289-3h3kmjlz 310 12 . . . cord-328289-3h3kmjlz 311 1 bioRxiv biorxiv RB cord-328289-3h3kmjlz 312 1 Steroid steroid NN cord-328289-3h3kmjlz 312 2 - - HYPH cord-328289-3h3kmjlz 312 3 Responsive Responsive NNP cord-328289-3h3kmjlz 312 4 Encephalitis Encephalitis NNP cord-328289-3h3kmjlz 312 5 in in IN cord-328289-3h3kmjlz 312 6 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 312 7 Disease Disease NNP cord-328289-3h3kmjlz 313 1 The the DT cord-328289-3h3kmjlz 313 2 Spectrum Spectrum NNP cord-328289-3h3kmjlz 313 3 of of IN cord-328289-3h3kmjlz 313 4 Neurologic Neurologic NNP cord-328289-3h3kmjlz 313 5 Disease Disease NNP cord-328289-3h3kmjlz 313 6 in in IN cord-328289-3h3kmjlz 313 7 the the DT cord-328289-3h3kmjlz 313 8 Severe severe JJ cord-328289-3h3kmjlz 313 9 Acute acute JJ cord-328289-3h3kmjlz 313 10 Respiratory Respiratory NNP cord-328289-3h3kmjlz 313 11 Syndrome Syndrome NNP cord-328289-3h3kmjlz 313 12 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 313 13 2 2 CD cord-328289-3h3kmjlz 313 14 Pandemic Pandemic NNP cord-328289-3h3kmjlz 313 15 Infection infection NN cord-328289-3h3kmjlz 313 16 : : : cord-328289-3h3kmjlz 313 17 Neurologists neurologist NNS cord-328289-3h3kmjlz 313 18 Move move VBP cord-328289-3h3kmjlz 313 19 to to IN cord-328289-3h3kmjlz 313 20 the the DT cord-328289-3h3kmjlz 313 21 Frontlines Frontlines NNPS cord-328289-3h3kmjlz 313 22 Magnetic Magnetic NNP cord-328289-3h3kmjlz 313 23 Resonance Resonance NNP cord-328289-3h3kmjlz 313 24 Imaging Imaging NNP cord-328289-3h3kmjlz 313 25 Alteration Alteration NNP cord-328289-3h3kmjlz 313 26 of of IN cord-328289-3h3kmjlz 313 27 the the DT cord-328289-3h3kmjlz 313 28 Brain Brain NNP cord-328289-3h3kmjlz 313 29 in in IN cord-328289-3h3kmjlz 313 30 a a DT cord-328289-3h3kmjlz 313 31 Patient patient NN cord-328289-3h3kmjlz 313 32 With with IN cord-328289-3h3kmjlz 313 33 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 313 34 Disease Disease NNP cord-328289-3h3kmjlz 313 35 2019 2019 CD cord-328289-3h3kmjlz 313 36 ( ( -LRB- cord-328289-3h3kmjlz 313 37 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 313 38 ) ) -RRB- cord-328289-3h3kmjlz 313 39 and and CC cord-328289-3h3kmjlz 313 40 Anosmia Anosmia NNP cord-328289-3h3kmjlz 313 41 COVID-19-associated covid-19-associate VBD cord-328289-3h3kmjlz 313 42 Acute acute JJ cord-328289-3h3kmjlz 313 43 Hemorrhagic Hemorrhagic NNP cord-328289-3h3kmjlz 313 44 Necrotizing Necrotizing NNP cord-328289-3h3kmjlz 313 45 Encephalopathy encephalopathy NN cord-328289-3h3kmjlz 313 46 : : : cord-328289-3h3kmjlz 313 47 Imaging imaging NN cord-328289-3h3kmjlz 313 48 Features Features NNPS cord-328289-3h3kmjlz 313 49 Dysregulation Dysregulation NNP cord-328289-3h3kmjlz 313 50 of of IN cord-328289-3h3kmjlz 313 51 Immune Immune NNP cord-328289-3h3kmjlz 313 52 Response response NN cord-328289-3h3kmjlz 313 53 in in IN cord-328289-3h3kmjlz 313 54 Patients patient NNS cord-328289-3h3kmjlz 313 55 With with IN cord-328289-3h3kmjlz 313 56 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 313 57 Immune Immune NNP cord-328289-3h3kmjlz 313 58 complement complement NN cord-328289-3h3kmjlz 313 59 and and CC cord-328289-3h3kmjlz 313 60 coagulation coagulation NN cord-328289-3h3kmjlz 313 61 dysfunction dysfunction NN cord-328289-3h3kmjlz 313 62 in in IN cord-328289-3h3kmjlz 313 63 adverse adverse JJ cord-328289-3h3kmjlz 313 64 outcomes outcome NNS cord-328289-3h3kmjlz 313 65 of of IN cord-328289-3h3kmjlz 313 66 SARS SARS NNP cord-328289-3h3kmjlz 313 67 - - HYPH cord-328289-3h3kmjlz 313 68 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 313 69 infection infection NN cord-328289-3h3kmjlz 313 70 Neuropathology Neuropathology NNP cord-328289-3h3kmjlz 313 71 of of IN cord-328289-3h3kmjlz 313 72 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 313 73 : : : cord-328289-3h3kmjlz 313 74 a a DT cord-328289-3h3kmjlz 313 75 spectrum spectrum NN cord-328289-3h3kmjlz 313 76 of of IN cord-328289-3h3kmjlz 313 77 vascular vascular JJ cord-328289-3h3kmjlz 313 78 and and CC cord-328289-3h3kmjlz 313 79 acute acute JJ cord-328289-3h3kmjlz 313 80 disseminated disseminate VBN cord-328289-3h3kmjlz 313 81 encephalomyelitis encephalomyelitis NN cord-328289-3h3kmjlz 313 82 ( ( -LRB- cord-328289-3h3kmjlz 313 83 ADEM)-like ADEM)-like NNP cord-328289-3h3kmjlz 313 84 pathology pathology NN cord-328289-3h3kmjlz 313 85 Psychiatric psychiatric JJ cord-328289-3h3kmjlz 313 86 and and CC cord-328289-3h3kmjlz 313 87 neuropsychiatric neuropsychiatric JJ cord-328289-3h3kmjlz 313 88 presentations presentation NNS cord-328289-3h3kmjlz 313 89 associated associate VBN cord-328289-3h3kmjlz 313 90 with with IN cord-328289-3h3kmjlz 313 91 severe severe JJ cord-328289-3h3kmjlz 313 92 coronavirus coronavirus NN cord-328289-3h3kmjlz 313 93 infections infection NNS cord-328289-3h3kmjlz 313 94 : : : cord-328289-3h3kmjlz 313 95 a a DT cord-328289-3h3kmjlz 313 96 systematic systematic JJ cord-328289-3h3kmjlz 313 97 review review NN cord-328289-3h3kmjlz 313 98 and and CC cord-328289-3h3kmjlz 313 99 meta meta NNP cord-328289-3h3kmjlz 313 100 - - HYPH cord-328289-3h3kmjlz 313 101 analysis analysis NN cord-328289-3h3kmjlz 313 102 with with IN cord-328289-3h3kmjlz 313 103 comparison comparison NN cord-328289-3h3kmjlz 313 104 to to IN cord-328289-3h3kmjlz 313 105 the the DT cord-328289-3h3kmjlz 313 106 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 313 107 pandemic pandemic NN cord-328289-3h3kmjlz 313 108 Physiologic physiologic JJ cord-328289-3h3kmjlz 313 109 upper upper JJ cord-328289-3h3kmjlz 313 110 limits limit NNS cord-328289-3h3kmjlz 313 111 of of IN cord-328289-3h3kmjlz 313 112 pore pore NN cord-328289-3h3kmjlz 313 113 size size NN cord-328289-3h3kmjlz 313 114 of of IN cord-328289-3h3kmjlz 313 115 different different JJ cord-328289-3h3kmjlz 313 116 blood blood NN cord-328289-3h3kmjlz 313 117 capillary capillary JJ cord-328289-3h3kmjlz 313 118 types type NNS cord-328289-3h3kmjlz 313 119 and and CC cord-328289-3h3kmjlz 313 120 another another DT cord-328289-3h3kmjlz 313 121 perspective perspective NN cord-328289-3h3kmjlz 313 122 on on IN cord-328289-3h3kmjlz 313 123 the the DT cord-328289-3h3kmjlz 313 124 dual dual JJ cord-328289-3h3kmjlz 313 125 pore pore NN cord-328289-3h3kmjlz 313 126 theory theory NN cord-328289-3h3kmjlz 313 127 of of IN cord-328289-3h3kmjlz 313 128 microvascular microvascular JJ cord-328289-3h3kmjlz 313 129 permeability permeability NN cord-328289-3h3kmjlz 313 130 Cell cell NN cord-328289-3h3kmjlz 313 131 entry entry NN cord-328289-3h3kmjlz 313 132 mechanisms mechanism NNS cord-328289-3h3kmjlz 313 133 of of IN cord-328289-3h3kmjlz 313 134 SARS SARS NNP cord-328289-3h3kmjlz 313 135 - - HYPH cord-328289-3h3kmjlz 313 136 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 314 1 Elevated elevated JJ cord-328289-3h3kmjlz 314 2 calprotectin calprotectin NNS cord-328289-3h3kmjlz 314 3 and and CC cord-328289-3h3kmjlz 314 4 abnormal abnormal JJ cord-328289-3h3kmjlz 314 5 myeloid myeloid JJ cord-328289-3h3kmjlz 314 6 cell cell NN cord-328289-3h3kmjlz 314 7 subsets subset NNS cord-328289-3h3kmjlz 314 8 discriminate discriminate VBP cord-328289-3h3kmjlz 314 9 severe severe JJ cord-328289-3h3kmjlz 314 10 from from IN cord-328289-3h3kmjlz 314 11 mild mild JJ cord-328289-3h3kmjlz 314 12 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 314 13 Neuropathological Neuropathological NNP cord-328289-3h3kmjlz 314 14 Features Features NNPS cord-328289-3h3kmjlz 314 15 of of IN cord-328289-3h3kmjlz 314 16 Covid-19 covid-19 JJ cord-328289-3h3kmjlz 314 17 Neuroinvasive Neuroinvasive NNP cord-328289-3h3kmjlz 314 18 potential potential NN cord-328289-3h3kmjlz 314 19 of of IN cord-328289-3h3kmjlz 314 20 SARS SARS NNP cord-328289-3h3kmjlz 314 21 - - HYPH cord-328289-3h3kmjlz 314 22 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 314 23 revealed reveal VBD cord-328289-3h3kmjlz 314 24 in in IN cord-328289-3h3kmjlz 314 25 a a DT cord-328289-3h3kmjlz 314 26 human human JJ cord-328289-3h3kmjlz 314 27 brain brain NN cord-328289-3h3kmjlz 314 28 organoid organoid NN cord-328289-3h3kmjlz 314 29 model model NN cord-328289-3h3kmjlz 314 30 . . . cord-328289-3h3kmjlz 315 1 bioRxiv biorxiv RB cord-328289-3h3kmjlz 316 1 Renal renal JJ cord-328289-3h3kmjlz 316 2 histopathological histopathological JJ cord-328289-3h3kmjlz 316 3 analysis analysis NN cord-328289-3h3kmjlz 316 4 of of IN cord-328289-3h3kmjlz 316 5 26 26 CD cord-328289-3h3kmjlz 316 6 postmortem postmortem JJ cord-328289-3h3kmjlz 316 7 findings finding NNS cord-328289-3h3kmjlz 316 8 of of IN cord-328289-3h3kmjlz 316 9 patients patient NNS cord-328289-3h3kmjlz 316 10 with with IN cord-328289-3h3kmjlz 316 11 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 316 12 in in IN cord-328289-3h3kmjlz 316 13 China China NNP cord-328289-3h3kmjlz 316 14 Influenza Influenza NNP cord-328289-3h3kmjlz 316 15 virus virus NN cord-328289-3h3kmjlz 316 16 associated associate VBN cord-328289-3h3kmjlz 316 17 encephalopathy encephalopathy NN cord-328289-3h3kmjlz 317 1 COVID-19 covid-19 VB cord-328289-3h3kmjlz 317 2 : : : cord-328289-3h3kmjlz 317 3 the the DT cord-328289-3h3kmjlz 317 4 vasculature vasculature NN cord-328289-3h3kmjlz 317 5 unleashed unleash VBN cord-328289-3h3kmjlz 317 6 Breadth Breadth NNP cord-328289-3h3kmjlz 317 7 of of IN cord-328289-3h3kmjlz 317 8 concomitant concomitant JJ cord-328289-3h3kmjlz 317 9 immune immune JJ cord-328289-3h3kmjlz 317 10 responses response NNS cord-328289-3h3kmjlz 317 11 prior prior RB cord-328289-3h3kmjlz 317 12 to to IN cord-328289-3h3kmjlz 317 13 patient patient JJ cord-328289-3h3kmjlz 317 14 recovery recovery NN cord-328289-3h3kmjlz 317 15 : : : cord-328289-3h3kmjlz 317 16 a a DT cord-328289-3h3kmjlz 317 17 case case NN cord-328289-3h3kmjlz 317 18 report report NN cord-328289-3h3kmjlz 317 19 of of IN cord-328289-3h3kmjlz 317 20 non non JJ cord-328289-3h3kmjlz 317 21 - - JJ cord-328289-3h3kmjlz 317 22 severe severe JJ cord-328289-3h3kmjlz 317 23 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 317 24 Guillain Guillain NNP cord-328289-3h3kmjlz 317 25 - - HYPH cord-328289-3h3kmjlz 317 26 Barre Barre NNP cord-328289-3h3kmjlz 317 27 Syndrome Syndrome NNP cord-328289-3h3kmjlz 317 28 Associated Associated NNP cord-328289-3h3kmjlz 317 29 with with IN cord-328289-3h3kmjlz 317 30 SARS SARS NNP cord-328289-3h3kmjlz 317 31 - - HYPH cord-328289-3h3kmjlz 317 32 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 317 33 Immunology Immunology NNP cord-328289-3h3kmjlz 317 34 of of IN cord-328289-3h3kmjlz 317 35 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 317 36 : : : cord-328289-3h3kmjlz 317 37 Current current JJ cord-328289-3h3kmjlz 317 38 State State NNP cord-328289-3h3kmjlz 317 39 of of IN cord-328289-3h3kmjlz 317 40 the the DT cord-328289-3h3kmjlz 317 41 Science Science NNP cord-328289-3h3kmjlz 317 42 Case Case NNP cord-328289-3h3kmjlz 317 43 definitions definition NNS cord-328289-3h3kmjlz 317 44 , , , cord-328289-3h3kmjlz 317 45 diagnostic diagnostic JJ cord-328289-3h3kmjlz 317 46 algorithms algorithm NNS cord-328289-3h3kmjlz 317 47 , , , cord-328289-3h3kmjlz 317 48 and and CC cord-328289-3h3kmjlz 317 49 priorities priority NNS cord-328289-3h3kmjlz 317 50 in in IN cord-328289-3h3kmjlz 317 51 encephalitis encephalitis NN cord-328289-3h3kmjlz 317 52 : : : cord-328289-3h3kmjlz 317 53 consensus consensus NN cord-328289-3h3kmjlz 317 54 statement statement NN cord-328289-3h3kmjlz 317 55 of of IN cord-328289-3h3kmjlz 317 56 the the DT cord-328289-3h3kmjlz 317 57 international international NNP cord-328289-3h3kmjlz 317 58 encephalitis encephalitis NNP cord-328289-3h3kmjlz 317 59 consortium consortium NN cord-328289-3h3kmjlz 317 60 Clinical Clinical NNP cord-328289-3h3kmjlz 317 61 Characteristics characteristic NNS cord-328289-3h3kmjlz 317 62 of of IN cord-328289-3h3kmjlz 317 63 138 138 CD cord-328289-3h3kmjlz 317 64 Hospitalized hospitalize VBN cord-328289-3h3kmjlz 317 65 Patients patient NNS cord-328289-3h3kmjlz 317 66 With with IN cord-328289-3h3kmjlz 317 67 2019 2019 CD cord-328289-3h3kmjlz 317 68 Novel Novel NNP cord-328289-3h3kmjlz 317 69 Coronavirus Coronavirus NNP cord-328289-3h3kmjlz 317 70 - - HYPH cord-328289-3h3kmjlz 317 71 Infected infect VBN cord-328289-3h3kmjlz 317 72 Pneumonia Pneumonia NNP cord-328289-3h3kmjlz 317 73 in in IN cord-328289-3h3kmjlz 317 74 SARS SARS NNP cord-328289-3h3kmjlz 317 75 - - HYPH cord-328289-3h3kmjlz 317 76 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 317 77 invades invade VBZ cord-328289-3h3kmjlz 317 78 host host NN cord-328289-3h3kmjlz 317 79 cells cell NNS cord-328289-3h3kmjlz 317 80 via via IN cord-328289-3h3kmjlz 317 81 a a DT cord-328289-3h3kmjlz 317 82 novel novel JJ cord-328289-3h3kmjlz 317 83 route route NN cord-328289-3h3kmjlz 317 84 : : : cord-328289-3h3kmjlz 317 85 CD147-spike cd147-spike JJ cord-328289-3h3kmjlz 317 86 protein protein NN cord-328289-3h3kmjlz 317 87 Detection Detection NNP cord-328289-3h3kmjlz 317 88 of of IN cord-328289-3h3kmjlz 317 89 SARS SARS NNP cord-328289-3h3kmjlz 317 90 - - HYPH cord-328289-3h3kmjlz 317 91 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 317 92 in in IN cord-328289-3h3kmjlz 317 93 Different different JJ cord-328289-3h3kmjlz 317 94 Types type NNS cord-328289-3h3kmjlz 317 95 of of IN cord-328289-3h3kmjlz 317 96 Clinical clinical JJ cord-328289-3h3kmjlz 317 97 Specimens specimen NNS cord-328289-3h3kmjlz 318 1 Can Can MD cord-328289-3h3kmjlz 318 2 Covid Covid NNP cord-328289-3h3kmjlz 318 3 Damage damage VB cord-328289-3h3kmjlz 318 4 the the DT cord-328289-3h3kmjlz 318 5 Brain Brain NNP cord-328289-3h3kmjlz 318 6 ? ? . cord-328289-3h3kmjlz 319 1 Pathological pathological JJ cord-328289-3h3kmjlz 319 2 findings finding NNS cord-328289-3h3kmjlz 319 3 of of IN cord-328289-3h3kmjlz 319 4 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 319 5 associated associate VBN cord-328289-3h3kmjlz 319 6 with with IN cord-328289-3h3kmjlz 319 7 acute acute JJ cord-328289-3h3kmjlz 319 8 respiratory respiratory JJ cord-328289-3h3kmjlz 319 9 distress distress NN cord-328289-3h3kmjlz 319 10 syndrome syndrome NN cord-328289-3h3kmjlz 319 11 SARS SARS NNP cord-328289-3h3kmjlz 319 12 - - HYPH cord-328289-3h3kmjlz 319 13 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 319 14 and and CC cord-328289-3h3kmjlz 319 15 Stroke Stroke NNP cord-328289-3h3kmjlz 319 16 in in IN cord-328289-3h3kmjlz 319 17 a a DT cord-328289-3h3kmjlz 319 18 New New NNP cord-328289-3h3kmjlz 319 19 York York NNP cord-328289-3h3kmjlz 319 20 Healthcare Healthcare NNP cord-328289-3h3kmjlz 319 21 System System NNP cord-328289-3h3kmjlz 319 22 A A NNP cord-328289-3h3kmjlz 319 23 Human human JJ cord-328289-3h3kmjlz 319 24 Pluripotent pluripotent JJ cord-328289-3h3kmjlz 319 25 Stem Stem NNP cord-328289-3h3kmjlz 319 26 Cell cell NN cord-328289-3h3kmjlz 319 27 - - HYPH cord-328289-3h3kmjlz 319 28 based base VBN cord-328289-3h3kmjlz 319 29 Platform Platform NNP cord-328289-3h3kmjlz 319 30 to to IN cord-328289-3h3kmjlz 319 31 Study study VB cord-328289-3h3kmjlz 320 1 SARS SARS NNP cord-328289-3h3kmjlz 320 2 - - HYPH cord-328289-3h3kmjlz 320 3 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 320 4 Tropism Tropism NNP cord-328289-3h3kmjlz 320 5 and and CC cord-328289-3h3kmjlz 320 6 Model Model NNP cord-328289-3h3kmjlz 320 7 Virus Virus NNP cord-328289-3h3kmjlz 320 8 Infection Infection NNP cord-328289-3h3kmjlz 320 9 in in IN cord-328289-3h3kmjlz 320 10 Human Human NNP cord-328289-3h3kmjlz 320 11 Cells Cells NNPS cord-328289-3h3kmjlz 320 12 and and CC cord-328289-3h3kmjlz 320 13 Organoids Organoids NNP cord-328289-3h3kmjlz 320 14 Encephalitis Encephalitis NNP cord-328289-3h3kmjlz 320 15 as as IN cord-328289-3h3kmjlz 320 16 a a DT cord-328289-3h3kmjlz 320 17 clinical clinical JJ cord-328289-3h3kmjlz 320 18 manifestation manifestation NN cord-328289-3h3kmjlz 320 19 of of IN cord-328289-3h3kmjlz 320 20 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 320 21 LY6E LY6E NNP cord-328289-3h3kmjlz 320 22 Restricts restrict VBZ cord-328289-3h3kmjlz 320 23 the the DT cord-328289-3h3kmjlz 320 24 Entry Entry NNP cord-328289-3h3kmjlz 320 25 of of IN cord-328289-3h3kmjlz 320 26 Human Human NNP cord-328289-3h3kmjlz 320 27 Coronaviruses Coronaviruses NNPS cord-328289-3h3kmjlz 320 28 , , , cord-328289-3h3kmjlz 320 29 Including include VBG cord-328289-3h3kmjlz 320 30 the the DT cord-328289-3h3kmjlz 320 31 Currently currently RB cord-328289-3h3kmjlz 320 32 Pandemic Pandemic NNP cord-328289-3h3kmjlz 320 33 SARS SARS NNP cord-328289-3h3kmjlz 320 34 - - HYPH cord-328289-3h3kmjlz 320 35 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 320 36 Viral viral JJ cord-328289-3h3kmjlz 320 37 load load NN cord-328289-3h3kmjlz 320 38 dynamics dynamic NNS cord-328289-3h3kmjlz 320 39 and and CC cord-328289-3h3kmjlz 320 40 disease disease NN cord-328289-3h3kmjlz 320 41 severity severity NN cord-328289-3h3kmjlz 320 42 in in IN cord-328289-3h3kmjlz 320 43 patients patient NNS cord-328289-3h3kmjlz 320 44 infected infect VBN cord-328289-3h3kmjlz 320 45 with with IN cord-328289-3h3kmjlz 320 46 SARS SARS NNP cord-328289-3h3kmjlz 320 47 - - HYPH cord-328289-3h3kmjlz 320 48 CoV-2 CoV-2 NNP cord-328289-3h3kmjlz 320 49 in in IN cord-328289-3h3kmjlz 320 50 Zhejiang Zhejiang NNP cord-328289-3h3kmjlz 320 51 province province NN cord-328289-3h3kmjlz 321 1 Heightened heighten VBN cord-328289-3h3kmjlz 321 2 Innate Innate NNP cord-328289-3h3kmjlz 321 3 Immune Immune NNP cord-328289-3h3kmjlz 321 4 Responses response NNS cord-328289-3h3kmjlz 321 5 in in IN cord-328289-3h3kmjlz 321 6 the the DT cord-328289-3h3kmjlz 321 7 Respiratory Respiratory NNP cord-328289-3h3kmjlz 321 8 Tract Tract NNP cord-328289-3h3kmjlz 321 9 of of IN cord-328289-3h3kmjlz 321 10 COVID-19 COVID-19 NNP cord-328289-3h3kmjlz 321 11 Patients patient NNS cord-328289-3h3kmjlz 322 1 The the DT cord-328289-3h3kmjlz 322 2 authors author NNS cord-328289-3h3kmjlz 322 3 are be VBP cord-328289-3h3kmjlz 322 4 supported support VBN cord-328289-3h3kmjlz 322 5 by by IN cord-328289-3h3kmjlz 322 6 NIH NIH NNP cord-328289-3h3kmjlz 322 7 grants grant NNS cord-328289-3h3kmjlz 322 8 R01-NS34179 R01-NS34179 NNP cord-328289-3h3kmjlz 322 9 , , , cord-328289-3h3kmjlz 322 10 R01-NS100447 R01-NS100447 NNP cord-328289-3h3kmjlz 322 11 , , , cord-328289-3h3kmjlz 322 12 R37-NS089323 R37-NS089323 NNP cord-328289-3h3kmjlz 322 13 , , , cord-328289-3h3kmjlz 322 14 R01-NS095441 R01-NS095441 NNP cord-328289-3h3kmjlz 322 15 , , , cord-328289-3h3kmjlz 322 16 R01-NS r01-ns NN cord-328289-3h3kmjlz 322 17 / / SYM cord-328289-3h3kmjlz 322 18 HL37853 HL37853 NNP cord-328289-3h3kmjlz 322 19 ( ( -LRB- cord-328289-3h3kmjlz 322 20 CI CI NNP cord-328289-3h3kmjlz 322 21 ) ) -RRB- cord-328289-3h3kmjlz 322 22 , , , cord-328289-3h3kmjlz 322 23 R01NS097443 R01NS097443 NNP cord-328289-3h3kmjlz 322 24 ( ( -LRB- cord-328289-3h3kmjlz 322 25 HK HK NNP cord-328289-3h3kmjlz 322 26 ) ) -RRB- cord-328289-3h3kmjlz 322 27 , , , cord-328289-3h3kmjlz 322 28 NS094507 NS094507 NNP cord-328289-3h3kmjlz 322 29 , , , cord-328289-3h3kmjlz 322 30 NS081179 NS081179 NNP cord-328289-3h3kmjlz 322 31 ( ( -LRB- cord-328289-3h3kmjlz 322 32 JA JA NNP cord-328289-3h3kmjlz 322 33 ) ) -RRB- cord-328289-3h3kmjlz 322 34 , , .