id author title date pages extension mime words sentences flesch summary cache txt cord-269363-drjj705k Nenchev, Vladislav Optimal quarantine control of an infectious outbreak 2020-07-28 .txt text/plain 4232 267 58 An issue of practical concern for many disease outbreaks without an available vaccine, such as for SARS-CoV-2 as of June 2020, is minimizing the overall quarantine effort or the final outbreak size, while respecting control and capacity constraints on the current number of infections. Upon an outbreak of a previously unknown disease, better model parameter estimates can be obtained as more data becomes available, and the induced optimization problem can be recomputed in a data-driven receding horizon manner to improve actions. In this work, the goal is to obtain an optimal quarantine control policy u ( t ), t ∈ [0, t f ] for a fixed final time t f , that minimizes a weighted combination of the total number of infections and the overall number of quarantined individuals at time t f . ./cache/cord-269363-drjj705k.txt ./txt/cord-269363-drjj705k.txt