id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007296-q9rn75qb	Muether, Philipp S.	Variant Effect of First- and Second-Generation Antihistamines as Clues to Their Mechanism of Action on the Sneeze Reflex in the Common Cold	2001-11-01		.txt	text/plain	2975	163	46	Treatment with first-generation antihistamines reduces sneezing, rhinorrhea, nasal mucus weight, and, in some instances, cough in subjects with experimental or natural colds; however, treatment with second-generation antihistamines has not been effective for these complaints in trials in subjects with natural colds. The effectiveness of first-generation antihistamines in blocking sneezing in colds may be due primarily to neuropharmacological manipulation of histaminic and muscarinic receptors in the medulla. Also, treatment with first-generation antihistamines is highly effective in reducing sneezing in subjects with experimental and natural colds [3] [4] [5] . Therefore, it would be desirable to confirm the results of the natural cold studies by testing a second-generation antihistamine in the rhinovirus challenge model, which provides more precision in the measurement of sneezing. Although the study was originally designed to determine whether loratadine by down-regulating expression of intercellular adhesion molecule-1 (ICAM-1) on nasal epithelial cells reduces rhinovirus infection rates, it provides heretoforemissing information on the results of testing a second-generation antihistamine in the virus challenge mode.	./cache/cord-007296-q9rn75qb.txt	./txt/cord-007296-q9rn75qb.txt