id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-032234-pfr4l1v9	Poloni, Chad	Evaluating Immune Dysregulation in Patients With COVID-19 Requires a More Accurate Definition of the CD45RA(+) T-cell Phenotype	2020-06-04		.txt	text/plain	679	42	49	The recently published study conducted in Wuhan, China, by Qin et al indicated dysregulation of the immune response specifically related to T lymphocytes, suggesting that they are highly involved in the pathophysiology of COVID-19 [1] . T-cell dysregulation is a major contributor to age-related changes of the immune system in the elderly, where T-cell responses become defective. Qin et al sought to characterize the T-lymphocyte responses in COVID-19, with aims to differentiate between nonsevere and severe cases. The Wuhan study also identified several differences in T-cell populations between the severe and nonsevere COVID-19 cases. This terminally differentiated T-cell population has been associated with immune dysregulation in the elderly and is further characterized by low CD28 and increased CD57 expression [9] . Improved characterization of terminally differentiated CD45RA + T cells, along with screening for IRP positivity, may be beneficial in identifying those with potential for severe COVID-19.	./cache/cord-032234-pfr4l1v9.txt	./txt/cord-032234-pfr4l1v9.txt