id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279932-bilr71ay	Plotkin, Stanley A	The Value of Human Challenges in Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Development	2020-07-16		.txt	text/plain	1119	61	52	A number of people, including Nguyen et al [1] in this issue and others [2] [3] [4] [5] [6] [7] elsewhere, have proposed the use of human challenge trials as a way of confirming the protective ability of candidate vaccines, in order to allow emergency use in high-risk groups and to facilitate the way to eventual licensure and use in the general population. The idea behind human challenge trials is to recruit young, healthy volunteers who have the lowest chance of serious disease, who would be given vaccine candidates and then be challenged with SARS-CoV-2 in order to determine whether the vaccines protect. Aside from the ethical issues, the principal objection to human challenge trials with SARS-CoV-2 is the absence of a reliable rescue medication for the treatment of serious disease. Evaluating use cases for human challenge trials in accelerating SARS-CoV-2 vaccine development	./cache/cord-279932-bilr71ay.txt	./txt/cord-279932-bilr71ay.txt