id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303968-ikr6eeov	Perinel, Sophie	Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients	2020-04-07		.txt	text/plain	1933	125	61	Apart from the ongoing clinical evaluation of the efficacy of HCQ, little information is available concerning the modalities of administration of this drug for Intensive Care Unit (ICU) patients, especially in the context of COVID-19. M a n u s c r i p t Treatment Patients received 200 mg of oral HCQ, three times daily, as suggested by a recent study [9] . To more clearly understand HCQ PK and the effect of the dosing regimen, a simulation based on a PK population study in patients with rheumatoid arthritis was performed [2] . In this study, we demonstrated that the 200 mg three times daily dosing regimen is inappropriate to reach a supposed target blood level of 1 -2 mg/L in this population. This regimen could constitute an appropriate option, although the results of our study suggest that 800 mg once daily on the first day can more rapidly reach therapeutic levels in ICU patients.	./cache/cord-303968-ikr6eeov.txt	./txt/cord-303968-ikr6eeov.txt