id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304487-ycvu5l5f	Wertheim, Joel O	A glimpse into the origins of genetic diversity in SARS-CoV-2	2020-03-04		.txt	text/plain	1202	74	43	Evolution tinkers with these viruses in bats, and the epidemiological consequences are seen both in pathogenic zoonotic diseases (e.g., SARS, MERS, and COVID-19) and in the less-virulent circulating coronaviruses causing common colds. Molecular epidemiology can use the genetic variation of SARS-CoV-2 to trace its history and better understand clusters of transmission. However, deep-sequencing of viral genomes from 7 patients (including this probable transmission pair), the authors detect substantial variation in the number and frequency of minority variants within different individuals. The evolutionary history of MERS-CoV in its intermediate host, camels, is littered with recombination events [6] . However, as the number of infections increases and the circulating viruses become more genetically distinct, natural selection will become more efficient, making viral adaptation more of a possibility. For now, SARS-CoV-2 genetic variation is likely evolutionarily inconsequential and will be more important for facilitating molecular epidemiology in tracing the origins of novel clusters of viral infection.	./cache/cord-304487-ycvu5l5f.txt	./txt/cord-304487-ycvu5l5f.txt