id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-322448-s04e6po9	Gadsby, Naomi J.	Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia	2016-04-01		.txt	text/plain	4371	206	34	Sputum (96%) or endotracheal aspirate (4%) specimens were cultured as per routine practice and also tested with fast multiplex real-time polymerase-chain reaction (PCR) assays for 26 respiratory bacteria and viruses. Comprehensive molecular testing of single lower respiratory tract (LRT) specimens achieved pathogen detection in 87% of CAP patients compared with 39% with culture-based methods. Comprehensive molecular testing significantly improves pathogen detection in CAP, particularly in antimicrobial-exposed patients, and requires only a single LRT specimen. The development of multiplex real-time polymerase-chain reaction (PCR) assays currently enables a respiratory specimen to be rapidly screened for a wide range of viral and atypical bacterial pathogens in a small number of reactions [10] [11] [12] [13] [14] [15] . As our study focused on testing sputum by molecular methods, our high level of pathogen detection for typical bacteria may not be directly comparable to results from other recent studies in hospitalized adult CAP.	./cache/cord-322448-s04e6po9.txt	./txt/cord-322448-s04e6po9.txt