id author title date pages extension mime words sentences flesch summary cache txt cord-324707-9ld73wv1 Mitjà, Oriol Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial 2020-07-16 .txt text/plain 4268 263 54 Study outcomes were the reduction of viral RNA load in nasopharyngeal swabs up to 7 days after treatment start, patient disease progression using the WHO scale up to 28 days, and time to complete resolution of symptoms. Adult patients aged 18 years or more were eligible if they had mild symptoms of Covid-19 (i.e., fever, acute cough, shortness of breath, sudden olfactory or gustatory loss, or influenza-like-illness) for less than five days before enrollment, were non-hospitalized, and had a positive PCR test for SARS-CoV-2 in the baseline nasopharyngeal swab. We estimated that a sample size of 280 patients would provide the trial with 80% power to detect a difference of 0.5 log 10 in the mean reduction of SARS-CoV-2 viral load at a two-sided significance level of α = 0.05, assuming an expected standard deviation of 1.5 [23] . ./cache/cord-324707-9ld73wv1.txt ./txt/cord-324707-9ld73wv1.txt