id author title date pages extension mime words sentences flesch summary cache txt cord-333943-9d93na7s Jeong, Han Eol Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study 2020-07-27 .txt text/plain 3387 218 47 title: Association between NSAIDs use and adverse clinical outcomes among adults hospitalized with COVID-19 in South Korea: A nationwide study BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) may exacerbate COVID-19 and worsen associated outcomes by upregulating the enzyme that SARS-CoV-2 binds to enter cells. [1, 2] Concerns exist that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may exacerbate COVID-19 by upregulating angiotensin-converting enzyme 2 (ACE2) expressions, [3, 4] the enzyme which SARS-CoV-2 binds to enter cells. This cohort study therefore aimed to examine the association between NSAIDs use, compared to non-use, and worsened clinical outcomes among adults hospitalized with A c c e p t e d M a n u s c r i p t page | 5 COVID-19 using South Korea's nationwide healthcare database containing all COVID-19 patients. To our knowledge, this is the first population-based study conducted using all hospitalized patients with COVID-19 to assess the association between NSAID use and COVID-19 related outcomes. ./cache/cord-333943-9d93na7s.txt ./txt/cord-333943-9d93na7s.txt