id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348144-t0chpsuh	Lucas, Alexander H.	Carbohydrate Moieties as Vaccine Candidates	2005-09-01		.txt	text/plain	5556	238	29	We discuss the cellular basis of carbohydrate immunity, newly identified glycotope processing pathways and recognition capabilities, and the synthetic and microarray technologies that are being developed that will permit new experimental approaches to carbohydrate vaccine development and the exploration of the interaction of the immune system with self and nonself glycans. It has long been known that bactericidal and/or opsonic antibodies directed against capsular polysaccharide (PS) glycotopes protect against invasive diseases caused by encapsulated bacteria, and, accordingly, vaccine development has focused on the elicitation of these antibody specificities. Purified microbial PS vaccines have been in use for 140 years, but they have proven to be variably immunogenic and variably efficacious in protecting susceptible populations against invasive meningococcal, pneumococcal, and Haemophilus influenzae type b (Hib) diseases [1, 2] . Significant variation in serotype-specific immunogenicity of the sevenvalent Streptococcus pneumoniae capsular polysaccharide-CRM197 conjugate vaccine occurs despite vigorous T cell help induced by the carrier protein	./cache/cord-348144-t0chpsuh.txt	./txt/cord-348144-t0chpsuh.txt