id author title date pages extension mime words sentences flesch summary cache txt cord-351348-lzo0dz7z Gu, Silan Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza 2020-06-04 .txt text/plain 1994 147 50 METHODS: We conducted a cross-sectional study of 30 COVID-19 patients, 24 influenza A (H1N1) patients, and 30 matched healthy controls (HC) to identify differences in the gut microbiota by 16S ribosomal RNA (rRNA) gene V3-V4 region sequencing. Previous studies indicated that the intestinal flora was closely related to respiratory virus infection and could affect the occurrence and development of diseases through the gut-lung axis [13] . The analysis of group similarities indicated that differences in richness, diversity, A c c e p t e d M a n u s c r i p t and structure of the gut microbiota were not significantly different between general and severe COVID-19 patients (ANOSIM, p=0.426; Supplementary Figure S1 ), indicating that the experimental design was adequate. The gut microbiota signature of COVID-19 and H1N1 patients was analyzed to assess correlations between disease characteristics and the microbiome. ./cache/cord-351348-lzo0dz7z.txt ./txt/cord-351348-lzo0dz7z.txt