id sid tid token lemma pos cord-015493-vf4et613 1 1 key key JJ cord-015493-vf4et613 2 1 : : : cord-015493-vf4et613 2 2 cord-015493-vf4et613 cord-015493-vf4et613 NN cord-015493-vf4et613 2 3 authors author NNS cord-015493-vf4et613 2 4 : : : cord-015493-vf4et613 3 1 Deresinski Deresinski NNP cord-015493-vf4et613 3 2 , , , cord-015493-vf4et613 3 3 Stan Stan NNP cord-015493-vf4et613 3 4 title title NN cord-015493-vf4et613 3 5 : : : cord-015493-vf4et613 4 1 In in IN cord-015493-vf4et613 4 2 the the DT cord-015493-vf4et613 4 3 Literature Literature NNP cord-015493-vf4et613 4 4 date date NN cord-015493-vf4et613 4 5 : : : cord-015493-vf4et613 4 6 2007 2007 CD cord-015493-vf4et613 4 7 - - SYM cord-015493-vf4et613 4 8 10 10 CD cord-015493-vf4et613 4 9 - - SYM cord-015493-vf4et613 4 10 15 15 CD cord-015493-vf4et613 4 11 journal journal NN cord-015493-vf4et613 4 12 : : : cord-015493-vf4et613 5 1 Clin Clin NNP cord-015493-vf4et613 5 2 Infect infect VB cord-015493-vf4et613 5 3 Dis Dis NNP cord-015493-vf4et613 5 4 DOI doi NN cord-015493-vf4et613 5 5 : : : cord-015493-vf4et613 6 1 10.1086/522526 10.1086/522526 CD cord-015493-vf4et613 7 1 sha sha NNP cord-015493-vf4et613 7 2 : : : cord-015493-vf4et613 7 3 a37fb9ea168570a2eff4a857e233312dff92a3bb a37fb9ea168570a2eff4a857e233312dff92a3bb . cord-015493-vf4et613 7 4 doc_id doc_id CD cord-015493-vf4et613 7 5 : : : cord-015493-vf4et613 7 6 15493 15493 CD cord-015493-vf4et613 7 7 cord_uid cord_uid FW cord-015493-vf4et613 7 8 : : : cord-015493-vf4et613 8 1 vf4et613 vf4et613 NNP cord-015493-vf4et613 8 2 nan nan NNP cord-015493-vf4et613 9 1 After after IN cord-015493-vf4et613 9 2 failing fail VBG cord-015493-vf4et613 9 3 to to TO cord-015493-vf4et613 9 4 detect detect VB cord-015493-vf4et613 9 5 nucleic nucleic JJ cord-015493-vf4et613 9 6 acid acid NN cord-015493-vf4et613 9 7 of of IN cord-015493-vf4et613 9 8 known know VBN cord-015493-vf4et613 9 9 respiratory respiratory JJ cord-015493-vf4et613 9 10 viruses virus NNS cord-015493-vf4et613 9 11 in in IN cord-015493-vf4et613 9 12 a a DT cord-015493-vf4et613 9 13 nasopharyngeal nasopharyngeal JJ cord-015493-vf4et613 9 14 aspirate aspirate NN cord-015493-vf4et613 9 15 specimen specimen NN cord-015493-vf4et613 9 16 obtained obtain VBN cord-015493-vf4et613 9 17 from from IN cord-015493-vf4et613 9 18 a a DT cord-015493-vf4et613 9 19 3-year 3-year CD cord-015493-vf4et613 9 20 - - HYPH cord-015493-vf4et613 9 21 old old JJ cord-015493-vf4et613 9 22 child child NN cord-015493-vf4et613 9 23 who who WP cord-015493-vf4et613 9 24 had have VBD cord-015493-vf4et613 9 25 been be VBN cord-015493-vf4et613 9 26 hospitalized hospitalize VBN cord-015493-vf4et613 9 27 in in IN cord-015493-vf4et613 9 28 Brisbane Brisbane NNP cord-015493-vf4et613 9 29 , , , cord-015493-vf4et613 9 30 Australia Australia NNP cord-015493-vf4et613 9 31 , , , cord-015493-vf4et613 9 32 with with IN cord-015493-vf4et613 9 33 pneumonia pneumonia NN cord-015493-vf4et613 9 34 , , , cord-015493-vf4et613 9 35 Gaynor Gaynor NNP cord-015493-vf4et613 9 36 and and CC cord-015493-vf4et613 9 37 colleagues colleague NNS cord-015493-vf4et613 9 38 , , , cord-015493-vf4et613 9 39 in in IN cord-015493-vf4et613 9 40 a a DT cord-015493-vf4et613 9 41 search search NN cord-015493-vf4et613 9 42 for for IN cord-015493-vf4et613 9 43 novel novel JJ cord-015493-vf4et613 9 44 viral viral JJ cord-015493-vf4et613 9 45 pathogens pathogen NNS cord-015493-vf4et613 9 46 , , , cord-015493-vf4et613 9 47 randomly randomly RB cord-015493-vf4et613 9 48 amplified amplify VBD cord-015493-vf4et613 9 49 and and CC cord-015493-vf4et613 9 50 cloned clone VBD cord-015493-vf4et613 9 51 total total JJ cord-015493-vf4et613 9 52 nucleic nucleic JJ cord-015493-vf4et613 9 53 acid acid NN cord-015493-vf4et613 9 54 from from IN cord-015493-vf4et613 9 55 the the DT cord-015493-vf4et613 9 56 specimen specimen NN cord-015493-vf4et613 9 57 . . . cord-015493-vf4et613 10 1 They -PRON- PRP cord-015493-vf4et613 10 2 then then RB cord-015493-vf4et613 10 3 sequenced sequence VBD cord-015493-vf4et613 10 4 a a DT cord-015493-vf4et613 10 5 384well 384well JJ cord-015493-vf4et613 10 6 plate plate NN cord-015493-vf4et613 10 7 of of IN cord-015493-vf4et613 10 8 clones clone NNS cord-015493-vf4et613 10 9 using use VBG cord-015493-vf4et613 10 10 a a DT cord-015493-vf4et613 10 11 universal universal JJ cord-015493-vf4et613 10 12 primer primer NN cord-015493-vf4et613 10 13 . . . cord-015493-vf4et613 11 1 This this DT cord-015493-vf4et613 11 2 yielded yield VBD cord-015493-vf4et613 11 3 multiple multiple JJ cord-015493-vf4et613 11 4 reads read NNS cord-015493-vf4et613 11 5 , , , cord-015493-vf4et613 11 6 6 6 CD cord-015493-vf4et613 11 7 of of IN cord-015493-vf4et613 11 8 which which WDT cord-015493-vf4et613 11 9 were be VBD cord-015493-vf4et613 11 10 of of IN cord-015493-vf4et613 11 11 sequences sequence NNS cord-015493-vf4et613 11 12 of of IN cord-015493-vf4et613 11 13 a a DT cord-015493-vf4et613 11 14 single single JJ cord-015493-vf4et613 11 15 virus virus NN cord-015493-vf4et613 11 16 . . . cord-015493-vf4et613 12 1 Further further JJ cord-015493-vf4et613 12 2 evaluation evaluation NN cord-015493-vf4et613 12 3 of of IN cord-015493-vf4et613 12 4 these these DT cord-015493-vf4et613 12 5 sequences sequence NNS cord-015493-vf4et613 12 6 demonstrated demonstrate VBD cord-015493-vf4et613 12 7 homology homology NN cord-015493-vf4et613 12 8 ( ( -LRB- cord-015493-vf4et613 12 9 albeit albeit RB cord-015493-vf4et613 12 10 limited limited JJ cord-015493-vf4et613 12 11 ) ) -RRB- cord-015493-vf4et613 12 12 to to IN cord-015493-vf4et613 12 13 known know VBN cord-015493-vf4et613 12 14 polyomaviruses polyomaviruse NNS cord-015493-vf4et613 12 15 , , , cord-015493-vf4et613 12 16 with with IN cord-015493-vf4et613 12 17 the the DT cord-015493-vf4et613 12 18 closest close JJS cord-015493-vf4et613 12 19 relationship relationship NN cord-015493-vf4et613 12 20 being be VBG cord-015493-vf4et613 12 21 to to IN cord-015493-vf4et613 12 22 KI KI NNP cord-015493-vf4et613 12 23 , , , cord-015493-vf4et613 12 24 a a DT cord-015493-vf4et613 12 25 polyomavirus polyomavirus NN cord-015493-vf4et613 12 26 that that WDT cord-015493-vf4et613 12 27 had have VBD cord-015493-vf4et613 12 28 recently recently RB cord-015493-vf4et613 12 29 been be VBN cord-015493-vf4et613 12 30 recovered recover VBN cord-015493-vf4et613 12 31 from from IN cord-015493-vf4et613 12 32 respiratory respiratory JJ cord-015493-vf4et613 12 33 tract tract NN cord-015493-vf4et613 12 34 samples sample NNS cord-015493-vf4et613 12 35 from from IN cord-015493-vf4et613 12 36 individuals individual NNS cord-015493-vf4et613 12 37 with with IN cord-015493-vf4et613 12 38 respiratory respiratory JJ cord-015493-vf4et613 12 39 symptoms symptom NNS cord-015493-vf4et613 12 40 [ [ -LRB- cord-015493-vf4et613 12 41 1 1 CD cord-015493-vf4et613 12 42 ] ] -RRB- cord-015493-vf4et613 12 43 . . . cord-015493-vf4et613 13 1 The the DT cord-015493-vf4et613 13 2 newly newly RB cord-015493-vf4et613 13 3 discovered discover VBN cord-015493-vf4et613 13 4 virus virus NN cord-015493-vf4et613 13 5 was be VBD cord-015493-vf4et613 13 6 designated designate VBN cord-015493-vf4et613 13 7 WU WU NNP cord-015493-vf4et613 13 8 , , , cord-015493-vf4et613 13 9 in in IN cord-015493-vf4et613 13 10 keeping keep VBG cord-015493-vf4et613 13 11 with with IN cord-015493-vf4et613 13 12 the the DT cord-015493-vf4et613 13 13 practice practice NN cord-015493-vf4et613 13 14 of of IN cord-015493-vf4et613 13 15 naming name VBG cord-015493-vf4et613 13 16 polyomaviruses polyomaviruse NNS cord-015493-vf4et613 13 17 with with IN cord-015493-vf4et613 13 18 2-letter 2-letter CD cord-015493-vf4et613 13 19 designations designation NNS cord-015493-vf4et613 13 20 ( ( -LRB- cord-015493-vf4et613 13 21 e.g. e.g. RB cord-015493-vf4et613 13 22 , , , cord-015493-vf4et613 13 23 KI KI NNP cord-015493-vf4et613 13 24 , , , cord-015493-vf4et613 13 25 JC JC NNP cord-015493-vf4et613 13 26 , , , cord-015493-vf4et613 13 27 and and CC cord-015493-vf4et613 13 28 BK BK NNP cord-015493-vf4et613 13 29 ) ) -RRB- cord-015493-vf4et613 13 30 . . . cord-015493-vf4et613 14 1 Phylogenetic phylogenetic JJ cord-015493-vf4et613 14 2 analysis analysis NN cord-015493-vf4et613 14 3 demonstrated demonstrate VBD cord-015493-vf4et613 14 4 that that IN cord-015493-vf4et613 14 5 WU WU NNP cord-015493-vf4et613 14 6 and and CC cord-015493-vf4et613 14 7 KI KI NNP cord-015493-vf4et613 14 8 are be VBP cord-015493-vf4et613 14 9 divergent divergent JJ cord-015493-vf4et613 14 10 from from IN cord-015493-vf4et613 14 11 other other JJ cord-015493-vf4et613 14 12 known know VBN cord-015493-vf4et613 14 13 polyomaviruses polyomaviruse NNS cord-015493-vf4et613 14 14 and and CC cord-015493-vf4et613 14 15 define define VB cord-015493-vf4et613 14 16 a a DT cord-015493-vf4et613 14 17 novel novel JJ cord-015493-vf4et613 14 18 branch branch NN cord-015493-vf4et613 14 19 within within IN cord-015493-vf4et613 14 20 this this DT cord-015493-vf4et613 14 21 family family NN cord-015493-vf4et613 14 22 . . . cord-015493-vf4et613 15 1 WU WU NNP cord-015493-vf4et613 15 2 was be VBD cord-015493-vf4et613 15 3 detected detect VBN cord-015493-vf4et613 15 4 by by IN cord-015493-vf4et613 15 5 PCR PCR NNP cord-015493-vf4et613 15 6 in in IN cord-015493-vf4et613 15 7 37 37 CD cord-015493-vf4et613 15 8 ( ( -LRB- cord-015493-vf4et613 15 9 3.0 3.0 CD cord-015493-vf4et613 15 10 % % NN cord-015493-vf4et613 15 11 ) ) -RRB- cord-015493-vf4et613 15 12 of of IN cord-015493-vf4et613 15 13 1245 1245 CD cord-015493-vf4et613 15 14 respiratory respiratory JJ cord-015493-vf4et613 15 15 specimens specimen NNS cord-015493-vf4et613 15 16 collected collect VBN cord-015493-vf4et613 15 17 in in IN cord-015493-vf4et613 15 18 Brisbane Brisbane NNP cord-015493-vf4et613 15 19 in in IN cord-015493-vf4et613 15 20 2003 2003 CD cord-015493-vf4et613 15 21 and and CC cord-015493-vf4et613 15 22 in in IN cord-015493-vf4et613 15 23 5 5 CD cord-015493-vf4et613 15 24 ( ( -LRB- cord-015493-vf4et613 15 25 1.2 1.2 CD cord-015493-vf4et613 15 26 % % NN cord-015493-vf4et613 15 27 ) ) -RRB- cord-015493-vf4et613 15 28 of of IN cord-015493-vf4et613 15 29 410 410 CD cord-015493-vf4et613 15 30 upper upper JJ cord-015493-vf4et613 15 31 respiratory respiratory JJ cord-015493-vf4et613 15 32 samples sample NNS cord-015493-vf4et613 15 33 collected collect VBN cord-015493-vf4et613 15 34 in in IN cord-015493-vf4et613 15 35 St. St. NNP cord-015493-vf4et613 15 36 Louis Louis NNP cord-015493-vf4et613 15 37 , , , cord-015493-vf4et613 15 38 Missouri Missouri NNP cord-015493-vf4et613 15 39 , , , cord-015493-vf4et613 15 40 as as RB cord-015493-vf4et613 15 41 well well RB cord-015493-vf4et613 15 42 as as IN cord-015493-vf4et613 15 43 in in IN cord-015493-vf4et613 15 44 1 1 CD cord-015493-vf4et613 15 45 of of IN cord-015493-vf4et613 15 46 480 480 CD cord-015493-vf4et613 15 47 bronchoalveolar bronchoalveolar JJ cord-015493-vf4et613 15 48 lavage lavage NN cord-015493-vf4et613 15 49 samples sample NNS cord-015493-vf4et613 15 50 obtained obtain VBN cord-015493-vf4et613 15 51 mostly mostly RB cord-015493-vf4et613 15 52 from from IN cord-015493-vf4et613 15 53 adults adult NNS cord-015493-vf4et613 15 54 , , , cord-015493-vf4et613 15 55 also also RB cord-015493-vf4et613 15 56 in in IN cord-015493-vf4et613 15 57 St. St. NNP cord-015493-vf4et613 15 58 Louis Louis NNP cord-015493-vf4et613 15 59 . . . cord-015493-vf4et613 16 1 In in IN cord-015493-vf4et613 16 2 Brisbane Brisbane NNP cord-015493-vf4et613 16 3 , , , cord-015493-vf4et613 16 4 the the DT cord-015493-vf4et613 16 5 samples sample NNS cord-015493-vf4et613 16 6 yielding yield VBG cord-015493-vf4et613 16 7 WU WU NNP cord-015493-vf4et613 16 8 were be VBD cord-015493-vf4et613 16 9 obtained obtain VBN cord-015493-vf4et613 16 10 from from IN cord-015493-vf4et613 16 11 individuals individual NNS cord-015493-vf4et613 16 12 aged age VBN cord-015493-vf4et613 16 13 from from IN cord-015493-vf4et613 16 14 4 4 CD cord-015493-vf4et613 16 15 months month NNS cord-015493-vf4et613 16 16 to to IN cord-015493-vf4et613 16 17 53 53 CD cord-015493-vf4et613 16 18 years year NNS cord-015493-vf4et613 16 19 , , , cord-015493-vf4et613 16 20 although although IN cord-015493-vf4et613 16 21 33 33 CD cord-015493-vf4et613 16 22 of of IN cord-015493-vf4et613 16 23 the the DT cord-015493-vf4et613 16 24 37 37 CD cord-015493-vf4et613 16 25 specimens specimen NNS cord-015493-vf4et613 16 26 were be VBD cord-015493-vf4et613 16 27 obtained obtain VBN cord-015493-vf4et613 16 28 from from IN cord-015493-vf4et613 16 29 persons person NNS cord-015493-vf4et613 16 30 aged age VBN cord-015493-vf4et613 16 31 р3 р3 NN cord-015493-vf4et613 16 32 years year NNS cord-015493-vf4et613 16 33 . . . cord-015493-vf4et613 17 1 At at RB cord-015493-vf4et613 17 2 least least JJS cord-015493-vf4et613 17 3 3 3 CD cord-015493-vf4et613 17 4 of of IN cord-015493-vf4et613 17 5 the the DT cord-015493-vf4et613 17 6 4 4 CD cord-015493-vf4et613 17 7 adults adult NNS cord-015493-vf4et613 17 8 in in IN cord-015493-vf4et613 17 9 whom whom WP cord-015493-vf4et613 17 10 WU WU NNP cord-015493-vf4et613 17 11 was be VBD cord-015493-vf4et613 17 12 detected detect VBN cord-015493-vf4et613 17 13 were be VBD cord-015493-vf4et613 17 14 signifi signifi NNP cord-015493-vf4et613 17 15 - - HYPH cord-015493-vf4et613 17 16 cantly cantly RB cord-015493-vf4et613 17 17 immunocompromised immunocompromised JJ cord-015493-vf4et613 17 18 , , , cord-015493-vf4et613 17 19 and and CC cord-015493-vf4et613 17 20 the the DT cord-015493-vf4et613 17 21 fourth fourth JJ cord-015493-vf4et613 17 22 had have VBD cord-015493-vf4et613 17 23 cirrhosis cirrhosis NN cord-015493-vf4et613 17 24 and and CC cord-015493-vf4et613 17 25 was be VBD cord-015493-vf4et613 17 26 undergoing undergo VBG cord-015493-vf4et613 17 27 mechanically mechanically RB cord-015493-vf4et613 17 28 ventilation ventilation NN cord-015493-vf4et613 17 29 . . . cord-015493-vf4et613 18 1 WU WU NNP cord-015493-vf4et613 18 2 was be VBD cord-015493-vf4et613 18 3 the the DT cord-015493-vf4et613 18 4 only only JJ cord-015493-vf4et613 18 5 virus virus NN cord-015493-vf4et613 18 6 recovered recover VBN cord-015493-vf4et613 18 7 from from IN cord-015493-vf4et613 18 8 12 12 CD cord-015493-vf4et613 18 9 patients patient NNS cord-015493-vf4et613 18 10 , , , cord-015493-vf4et613 18 11 whereas whereas IN cord-015493-vf4et613 18 12 at at RB cord-015493-vf4et613 18 13 least least JJS cord-015493-vf4et613 18 14 1 1 CD cord-015493-vf4et613 18 15 additional additional JJ cord-015493-vf4et613 18 16 virus virus NN cord-015493-vf4et613 18 17 was be VBD cord-015493-vf4et613 18 18 detected detect VBN cord-015493-vf4et613 18 19 in in IN cord-015493-vf4et613 18 20 the the DT cord-015493-vf4et613 18 21 other other JJ cord-015493-vf4et613 18 22 25 25 CD cord-015493-vf4et613 18 23 patients patient NNS cord-015493-vf4et613 18 24 ; ; : cord-015493-vf4et613 18 25 these these DT cord-015493-vf4et613 18 26 included include VBN cord-015493-vf4et613 18 27 rhinovirus rhinovirus NN cord-015493-vf4et613 18 28 ( ( -LRB- cord-015493-vf4et613 18 29 in in IN cord-015493-vf4et613 18 30 15 15 CD cord-015493-vf4et613 18 31 patients patient NNS cord-015493-vf4et613 18 32 ) ) -RRB- cord-015493-vf4et613 18 33 and and CC cord-015493-vf4et613 18 34 human human JJ cord-015493-vf4et613 18 35 bocavirus bocavirus NNP cord-015493-vf4et613 18 36 ( ( -LRB- cord-015493-vf4et613 18 37 in in IN cord-015493-vf4et613 18 38 10 10 CD cord-015493-vf4et613 18 39 patients patient NNS cord-015493-vf4et613 18 40 ) ) -RRB- cord-015493-vf4et613 18 41 . . . cord-015493-vf4et613 19 1 Three three CD cord-015493-vf4et613 19 2 viruses virus NNS cord-015493-vf4et613 19 3 were be VBD cord-015493-vf4et613 19 4 detected detect VBN cord-015493-vf4et613 19 5 in in IN cord-015493-vf4et613 19 6 6 6 CD cord-015493-vf4et613 19 7 samples sample NNS cord-015493-vf4et613 19 8 , , , cord-015493-vf4et613 19 9 and and CC cord-015493-vf4et613 19 10 1 1 CD cord-015493-vf4et613 19 11 sample sample NN cord-015493-vf4et613 19 12 contained contain VBN cord-015493-vf4et613 19 13 4 4 CD cord-015493-vf4et613 19 14 viruses virus NNS cord-015493-vf4et613 19 15 ( ( -LRB- cord-015493-vf4et613 19 16 WU WU NNP cord-015493-vf4et613 19 17 , , , cord-015493-vf4et613 19 18 bocavirus bocavirus NNP cord-015493-vf4et613 19 19 , , , cord-015493-vf4et613 19 20 rhinovirus rhinovirus NN cord-015493-vf4et613 19 21 , , , cord-015493-vf4et613 19 22 and and CC cord-015493-vf4et613 19 23 adenovirus adenovirus NN cord-015493-vf4et613 19 24 ) ) -RRB- cord-015493-vf4et613 19 25 . . . cord-015493-vf4et613 20 1 All all DT cord-015493-vf4et613 20 2 6 6 CD cord-015493-vf4et613 20 3 samples sample NNS cord-015493-vf4et613 20 4 from from IN cord-015493-vf4et613 20 5 St. St. NNP cord-015493-vf4et613 20 6 Louis Louis NNP cord-015493-vf4et613 20 7 that that WDT cord-015493-vf4et613 20 8 contained contain VBD cord-015493-vf4et613 20 9 WU WU NNP cord-015493-vf4et613 20 10 yielded yield VBD cord-015493-vf4et613 20 11 evidence evidence NN cord-015493-vf4et613 20 12 of of IN cord-015493-vf4et613 20 13 the the DT cord-015493-vf4et613 20 14 presence presence NN cord-015493-vf4et613 20 15 of of IN cord-015493-vf4et613 20 16 an an DT cord-015493-vf4et613 20 17 additional additional JJ cord-015493-vf4et613 20 18 virus virus NN cord-015493-vf4et613 20 19 . . . cord-015493-vf4et613 21 1 Overall overall RB cord-015493-vf4et613 21 2 , , , cord-015493-vf4et613 21 3 72 72 CD cord-015493-vf4et613 21 4 % % NN cord-015493-vf4et613 21 5 of of IN cord-015493-vf4et613 21 6 the the DT cord-015493-vf4et613 21 7 samples sample NNS cord-015493-vf4et613 21 8 that that WDT cord-015493-vf4et613 21 9 contained contain VBD cord-015493-vf4et613 21 10 WU WU NNP cord-015493-vf4et613 21 11 had have VBD cord-015493-vf4et613 21 12 evidence evidence NN cord-015493-vf4et613 21 13 of of IN cord-015493-vf4et613 21 14 coinfection coinfection NN cord-015493-vf4et613 21 15 with with IN cord-015493-vf4et613 21 16 у1 у1 JJ cord-015493-vf4et613 21 17 additional additional JJ cord-015493-vf4et613 21 18 virus virus NN cord-015493-vf4et613 21 19 . . . cord-015493-vf4et613 22 1 Because because IN cord-015493-vf4et613 22 2 the the DT cord-015493-vf4et613 22 3 BK BK NNP cord-015493-vf4et613 22 4 and and CC cord-015493-vf4et613 22 5 JC JC NNP cord-015493-vf4et613 22 6 polyomaviruses polyomaviruse NNS cord-015493-vf4et613 22 7 are be VBP cord-015493-vf4et613 22 8 commonly commonly RB cord-015493-vf4et613 22 9 found find VBN cord-015493-vf4et613 22 10 in in IN cord-015493-vf4et613 22 11 urine urine NN cord-015493-vf4et613 22 12 specimens specimen NNS cord-015493-vf4et613 22 13 , , , cord-015493-vf4et613 22 14 501 501 CD cord-015493-vf4et613 22 15 urine urine NN cord-015493-vf4et613 22 16 samples sample NNS cord-015493-vf4et613 22 17 obtained obtain VBN cord-015493-vf4et613 22 18 from from IN cord-015493-vf4et613 22 19 renal renal JJ cord-015493-vf4et613 22 20 transplant transplant NN cord-015493-vf4et613 22 21 recipients recipient NNS cord-015493-vf4et613 22 22 in in IN cord-015493-vf4et613 22 23 St. St. NNP cord-015493-vf4et613 22 24 Louis Louis NNP cord-015493-vf4et613 22 25 and and CC cord-015493-vf4et613 22 26 226 226 CD cord-015493-vf4et613 22 27 samples sample NNS cord-015493-vf4et613 22 28 obtained obtain VBN cord-015493-vf4et613 22 29 from from IN cord-015493-vf4et613 22 30 patients patient NNS cord-015493-vf4et613 22 31 in in IN cord-015493-vf4et613 22 32 Brisbane Brisbane NNP cord-015493-vf4et613 22 33 were be VBD cord-015493-vf4et613 22 34 screened screen VBN cord-015493-vf4et613 22 35 by by IN cord-015493-vf4et613 22 36 PCR PCR NNP cord-015493-vf4et613 22 37 ; ; : cord-015493-vf4et613 22 38 none none NN cord-015493-vf4et613 22 39 contained contain VBD cord-015493-vf4et613 22 40 WU WU NNP cord-015493-vf4et613 22 41 . . . cord-015493-vf4et613 23 1 These these DT cord-015493-vf4et613 23 2 findings finding NNS cord-015493-vf4et613 23 3 suggest suggest VBP cord-015493-vf4et613 23 4 - - : cord-015493-vf4et613 23 5 but but CC cord-015493-vf4et613 23 6 do do VBP cord-015493-vf4et613 23 7 not not RB cord-015493-vf4et613 23 8 prove prove VB cord-015493-vf4et613 23 9 - - : cord-015493-vf4et613 23 10 that that IN cord-015493-vf4et613 23 11 this this DT cord-015493-vf4et613 23 12 novel novel JJ cord-015493-vf4et613 23 13 polyomavirus polyomavirus NNP cord-015493-vf4et613 23 14 has have VBZ cord-015493-vf4et613 23 15 a a DT cord-015493-vf4et613 23 16 role role NN cord-015493-vf4et613 23 17 in in IN cord-015493-vf4et613 23 18 respiratory respiratory JJ cord-015493-vf4et613 23 19 tract tract NN cord-015493-vf4et613 23 20 infection infection NN cord-015493-vf4et613 23 21 . . . cord-015493-vf4et613 24 1 The the DT cord-015493-vf4et613 24 2 very very RB cord-015493-vf4et613 24 3 high high JJ cord-015493-vf4et613 24 4 frequency frequency NN cord-015493-vf4et613 24 5 of of IN cord-015493-vf4et613 24 6 detection detection NN cord-015493-vf4et613 24 7 of of IN cord-015493-vf4et613 24 8 additional additional JJ cord-015493-vf4et613 24 9 viruses virus NNS cord-015493-vf4et613 24 10 , , , cord-015493-vf4et613 24 11 which which WDT cord-015493-vf4et613 24 12 were be VBD cord-015493-vf4et613 24 13 detected detect VBN cord-015493-vf4et613 24 14 in in IN cord-015493-vf4et613 24 15 almost almost RB cord-015493-vf4et613 24 16 three three CD cord-015493-vf4et613 24 17 - - HYPH cord-015493-vf4et613 24 18 fourths fourth NNS cord-015493-vf4et613 24 19 of of IN cord-015493-vf4et613 24 20 the the DT cord-015493-vf4et613 24 21 patients patient NNS cord-015493-vf4et613 24 22 , , , cord-015493-vf4et613 24 23 complicates complicate VBZ cord-015493-vf4et613 24 24 the the DT cord-015493-vf4et613 24 25 analysis analysis NN cord-015493-vf4et613 24 26 . . . cord-015493-vf4et613 25 1 Nonetheless nonetheless RB cord-015493-vf4et613 25 2 , , , cord-015493-vf4et613 25 3 the the DT cord-015493-vf4et613 25 4 frequency frequency NN cord-015493-vf4et613 25 5 of of IN cord-015493-vf4et613 25 6 its -PRON- PRP$ cord-015493-vf4et613 25 7 detection detection NN cord-015493-vf4et613 25 8 in in IN cord-015493-vf4et613 25 9 individuals individual NNS cord-015493-vf4et613 25 10 ( ( -LRB- cord-015493-vf4et613 25 11 especially especially RB cord-015493-vf4et613 25 12 young young JJ cord-015493-vf4et613 25 13 children child NNS cord-015493-vf4et613 25 14 with with IN cord-015493-vf4et613 25 15 respiratory respiratory JJ cord-015493-vf4et613 25 16 symptoms symptom NNS cord-015493-vf4et613 25 17 ) ) -RRB- cord-015493-vf4et613 25 18 in in IN cord-015493-vf4et613 25 19 2 2 CD cord-015493-vf4et613 25 20 geographically geographically RB cord-015493-vf4et613 25 21 distinct distinct JJ cord-015493-vf4et613 25 22 areas area NNS cord-015493-vf4et613 25 23 highly highly RB cord-015493-vf4et613 25 24 suggests suggest VBZ cord-015493-vf4et613 25 25 that that IN cord-015493-vf4et613 25 26 it -PRON- PRP cord-015493-vf4et613 25 27 is be VBZ cord-015493-vf4et613 25 28 a a DT cord-015493-vf4et613 25 29 cause cause NN cord-015493-vf4et613 25 30 of of IN cord-015493-vf4et613 25 31 human human JJ cord-015493-vf4et613 25 32 disease disease NN cord-015493-vf4et613 25 33 . . . cord-015493-vf4et613 26 1 In in IN cord-015493-vf4et613 26 2 the the DT cord-015493-vf4et613 26 3 meantime meantime NN cord-015493-vf4et613 26 4 , , , cord-015493-vf4et613 26 5 we -PRON- PRP cord-015493-vf4et613 26 6 can can MD cord-015493-vf4et613 26 7 expect expect VB cord-015493-vf4et613 26 8 the the DT cord-015493-vf4et613 26 9 continued continue VBN cord-015493-vf4et613 26 10 identification identification NN cord-015493-vf4et613 26 11 of of IN cord-015493-vf4et613 26 12 additional additional JJ cord-015493-vf4et613 26 13 novel novel NN cord-015493-vf4et613 26 14 viruses virus NNS cord-015493-vf4et613 26 15 as as IN cord-015493-vf4et613 26 16 candidate candidate NN cord-015493-vf4et613 26 17 human human JJ cord-015493-vf4et613 26 18 respiratory respiratory JJ cord-015493-vf4et613 26 19 pathogens pathogen NNS cord-015493-vf4et613 26 20 and and CC cord-015493-vf4et613 26 21 can can MD cord-015493-vf4et613 26 22 add add VB cord-015493-vf4et613 26 23 WU WU NNP cord-015493-vf4et613 26 24 , , , cord-015493-vf4et613 26 25 along along IN cord-015493-vf4et613 26 26 with with IN cord-015493-vf4et613 26 27 the the DT cord-015493-vf4et613 26 28 recently recently RB cord-015493-vf4et613 26 29 identified identify VBN cord-015493-vf4et613 26 30 rhinovirus rhinovirus NN cord-015493-vf4et613 26 31 HRV HRV NNP cord-015493-vf4et613 26 32 - - HYPH cord-015493-vf4et613 26 33 QPM QPM NNP cord-015493-vf4et613 26 34 [ [ -LRB- cord-015493-vf4et613 26 35 2 2 CD cord-015493-vf4et613 26 36 ] ] -RRB- cord-015493-vf4et613 26 37 , , , cord-015493-vf4et613 26 38 to to IN cord-015493-vf4et613 26 39 the the DT cord-015493-vf4et613 26 40 list list NN cord-015493-vf4et613 26 41 of of IN cord-015493-vf4et613 26 42 viruses virus NNS cord-015493-vf4et613 26 43 identified identify VBN cord-015493-vf4et613 26 44 in in IN cord-015493-vf4et613 26 45 respiratory respiratory JJ cord-015493-vf4et613 26 46 tract tract NN cord-015493-vf4et613 26 47 specimens specimen NNS cord-015493-vf4et613 26 48 since since IN cord-015493-vf4et613 26 49 2001 2001 CD cord-015493-vf4et613 26 50 : : : cord-015493-vf4et613 26 51 human human NNP cord-015493-vf4et613 26 52 metapneumovirus metapneumovirus NNP cord-015493-vf4et613 26 53 , , , cord-015493-vf4et613 26 54 severe severe JJ cord-015493-vf4et613 26 55 acute acute JJ cord-015493-vf4et613 26 56 respiratory respiratory JJ cord-015493-vf4et613 26 57 syndrome syndrome NN cord-015493-vf4et613 26 58 coronavirus coronavirus NN cord-015493-vf4et613 26 59 , , , cord-015493-vf4et613 26 60 coronaviruses coronaviruse NNS cord-015493-vf4et613 26 61 NL63 NL63 NNP cord-015493-vf4et613 26 62 and and CC cord-015493-vf4et613 26 63 HKU1 HKU1 NNP cord-015493-vf4et613 26 64 , , , cord-015493-vf4et613 26 65 human human JJ cord-015493-vf4et613 26 66 bocavirus bocavirus NN cord-015493-vf4et613 26 67 , , , cord-015493-vf4et613 26 68 KI KI NNP cord-015493-vf4et613 26 69 polyomavirus polyomavirus NNP cord-015493-vf4et613 26 70 , , , cord-015493-vf4et613 26 71 and and CC cord-015493-vf4et613 26 72 now now RB cord-015493-vf4et613 26 73 HRV HRV NNP cord-015493-vf4et613 26 74 - - HYPH cord-015493-vf4et613 26 75 QPM QPM NNP cord-015493-vf4et613 26 76 ( ( -LRB- cord-015493-vf4et613 26 77 rhinovirus rhinovirus NN cord-015493-vf4et613 26 78 ) ) -RRB- cord-015493-vf4et613 26 79 and and CC cord-015493-vf4et613 26 80 WU WU NNP cord-015493-vf4et613 26 81 polyomavirus polyomavirus NNP cord-015493-vf4et613 26 82 . . . cord-015493-vf4et613 27 1 Ruhe Ruhe NNP cord-015493-vf4et613 27 2 JJ JJ NNP cord-015493-vf4et613 27 3 , , , cord-015493-vf4et613 27 4 Menon Menon NNP cord-015493-vf4et613 27 5 A. A. NNP cord-015493-vf4et613 27 6 Tetracyclines Tetracyclines NNP cord-015493-vf4et613 27 7 as as IN cord-015493-vf4et613 27 8 an an DT cord-015493-vf4et613 27 9 oral oral JJ cord-015493-vf4et613 27 10 treatment treatment NN cord-015493-vf4et613 27 11 option option NN cord-015493-vf4et613 27 12 for for IN cord-015493-vf4et613 27 13 patients patient NNS cord-015493-vf4et613 27 14 with with IN cord-015493-vf4et613 27 15 community community NN cord-015493-vf4et613 27 16 - - HYPH cord-015493-vf4et613 27 17 onset onset NN cord-015493-vf4et613 27 18 methicillin methicillin NN cord-015493-vf4et613 27 19 - - HYPH cord-015493-vf4et613 27 20 resistant resistant JJ cord-015493-vf4et613 27 21 Staphylococcus Staphylococcus NNP cord-015493-vf4et613 27 22 aureus aureus NN cord-015493-vf4et613 27 23 skin skin NN cord-015493-vf4et613 27 24 and and CC cord-015493-vf4et613 27 25 soft soft JJ cord-015493-vf4et613 27 26 - - HYPH cord-015493-vf4et613 27 27 tissue tissue NN cord-015493-vf4et613 27 28 infections infection NNS cord-015493-vf4et613 27 29 . . . cord-015493-vf4et613 28 1 Antimicrob Antimicrob NNP cord-015493-vf4et613 28 2 Agents Agents NNPS cord-015493-vf4et613 28 3 Chemother Chemother NNP cord-015493-vf4et613 28 4 2007 2007 CD cord-015493-vf4et613 28 5 ; ; : cord-015493-vf4et613 28 6 51:3298 51:3298 CD cord-015493-vf4et613 28 7 - - SYM cord-015493-vf4et613 28 8 303 303 CD cord-015493-vf4et613 28 9 . . . cord-015493-vf4et613 29 1 The the DT cord-015493-vf4et613 29 2 role role NN cord-015493-vf4et613 29 3 of of IN cord-015493-vf4et613 29 4 antibiotics antibiotic NNS cord-015493-vf4et613 29 5 in in IN cord-015493-vf4et613 29 6 the the DT cord-015493-vf4et613 29 7 treatment treatment NN cord-015493-vf4et613 29 8 of of IN cord-015493-vf4et613 29 9 uncomplicated uncomplicated JJ cord-015493-vf4et613 29 10 SSTI SSTI NNP cord-015493-vf4et613 29 11 due due IN cord-015493-vf4et613 29 12 to to IN cord-015493-vf4et613 29 13 community community NN cord-015493-vf4et613 29 14 - - HYPH cord-015493-vf4et613 29 15 acquired acquire VBN cord-015493-vf4et613 29 16 MRSA MRSA NNP cord-015493-vf4et613 29 17 has have VBZ cord-015493-vf4et613 29 18 been be VBN cord-015493-vf4et613 29 19 a a DT cord-015493-vf4et613 29 20 matter matter NN cord-015493-vf4et613 29 21 of of IN cord-015493-vf4et613 29 22 dispute dispute NN cord-015493-vf4et613 29 23 . . . cord-015493-vf4et613 30 1 Early early JJ cord-015493-vf4et613 30 2 reports report NNS cord-015493-vf4et613 30 3 suggested suggest VBD cord-015493-vf4et613 30 4 that that IN cord-015493-vf4et613 30 5 incision incision NN cord-015493-vf4et613 30 6 and and CC cord-015493-vf4et613 30 7 drainage drainage NN cord-015493-vf4et613 30 8 of of IN cord-015493-vf4et613 30 9 cutaneous cutaneous JJ cord-015493-vf4et613 30 10 abscesses abscess NNS cord-015493-vf4et613 30 11 due due JJ cord-015493-vf4et613 30 12 to to IN cord-015493-vf4et613 30 13 community community NN cord-015493-vf4et613 30 14 - - HYPH cord-015493-vf4et613 30 15 acquired acquire VBN cord-015493-vf4et613 30 16 MRSA MRSA NNP cord-015493-vf4et613 30 17 was be VBD cord-015493-vf4et613 30 18 sufficient sufficient JJ cord-015493-vf4et613 30 19 , , , cord-015493-vf4et613 30 20 at at IN cord-015493-vf4et613 30 21 least least JJS cord-015493-vf4et613 30 22 for for IN cord-015493-vf4et613 30 23 abscesses abscess NNS cord-015493-vf4et613 30 24 of of IN cord-015493-vf4et613 30 25 relatively relatively RB cord-015493-vf4et613 30 26 small small JJ cord-015493-vf4et613 30 27 size size NN cord-015493-vf4et613 30 28 . . . cord-015493-vf4et613 31 1 Newer new JJR cord-015493-vf4et613 31 2 , , , cord-015493-vf4et613 31 3 more more RBR cord-015493-vf4et613 31 4 convincing convincing JJ cord-015493-vf4et613 31 5 evidence evidence NN cord-015493-vf4et613 31 6 , , , cord-015493-vf4et613 31 7 however however RB cord-015493-vf4et613 31 8 , , , cord-015493-vf4et613 31 9 appears appear VBZ cord-015493-vf4et613 31 10 to to TO cord-015493-vf4et613 31 11 indicate indicate VB cord-015493-vf4et613 31 12 that that IN cord-015493-vf4et613 31 13 antibiotic antibiotic JJ cord-015493-vf4et613 31 14 treatment treatment NN cord-015493-vf4et613 31 15 does do VBZ cord-015493-vf4et613 31 16 matter matter NN cord-015493-vf4et613 31 17 . . . cord-015493-vf4et613 32 1 Ruhe Ruhe NNP cord-015493-vf4et613 32 2 and and CC cord-015493-vf4et613 32 3 colleagues colleague NNS cord-015493-vf4et613 32 4 retrospectively retrospectively RB cord-015493-vf4et613 32 5 examined examine VBD cord-015493-vf4et613 32 6 the the DT cord-015493-vf4et613 32 7 records record NNS cord-015493-vf4et613 32 8 of of IN cord-015493-vf4et613 32 9 282 282 CD cord-015493-vf4et613 32 10 patients patient NNS cord-015493-vf4et613 32 11 with with IN cord-015493-vf4et613 32 12 282 282 CD cord-015493-vf4et613 32 13 episodes episode NNS cord-015493-vf4et613 32 14 of of IN cord-015493-vf4et613 32 15 SSTI SSTI NNP cord-015493-vf4et613 32 16 due due IN cord-015493-vf4et613 32 17 to to IN cord-015493-vf4et613 32 18 MRSA MRSA NNP cord-015493-vf4et613 32 19 who who WP cord-015493-vf4et613 32 20 presented present VBD cord-015493-vf4et613 32 21 either either CC cord-015493-vf4et613 32 22 to to IN cord-015493-vf4et613 32 23 the the DT cord-015493-vf4et613 32 24 emergency emergency NN cord-015493-vf4et613 32 25 department department NN cord-015493-vf4et613 32 26 or or CC cord-015493-vf4et613 32 27 to to IN cord-015493-vf4et613 32 28 the the DT cord-015493-vf4et613 32 29 outpatient outpatient NN cord-015493-vf4et613 32 30 clinic clinic NN cord-015493-vf4et613 32 31 at at IN cord-015493-vf4et613 32 32 2 2 CD cord-015493-vf4et613 32 33 medical medical JJ cord-015493-vf4et613 32 34 centers center NNS cord-015493-vf4et613 32 35 during during IN cord-015493-vf4et613 32 36 the the DT cord-015493-vf4et613 32 37 period period NN cord-015493-vf4et613 32 38 2002 2002 CD cord-015493-vf4et613 32 39 - - SYM cord-015493-vf4et613 32 40 2007 2007 CD cord-015493-vf4et613 32 41 . . . cord-015493-vf4et613 33 1 Three three CD cord-015493-vf4et613 33 2 - - HYPH cord-015493-vf4et613 33 3 fourths fourth NNS cord-015493-vf4et613 33 4 of of IN cord-015493-vf4et613 33 5 patients patient NNS cord-015493-vf4et613 33 6 had have VBD cord-015493-vf4et613 33 7 abscesses abscess NNS cord-015493-vf4et613 33 8 , , , cord-015493-vf4et613 33 9 13 13 CD cord-015493-vf4et613 33 10 % % NN cord-015493-vf4et613 33 11 had have VBD cord-015493-vf4et613 33 12 furuncles furuncle NNS cord-015493-vf4et613 33 13 or or CC cord-015493-vf4et613 33 14 carbuncles carbuncle NNS cord-015493-vf4et613 33 15 , , , cord-015493-vf4et613 33 16 and and CC cord-015493-vf4et613 33 17 12 12 CD cord-015493-vf4et613 33 18 % % NN cord-015493-vf4et613 33 19 had have VBD cord-015493-vf4et613 33 20 cellulitis cellulitis NN cord-015493-vf4et613 33 21 with with IN cord-015493-vf4et613 33 22 a a DT cord-015493-vf4et613 33 23 purulent purulent JJ cord-015493-vf4et613 33 24 focus focus NN cord-015493-vf4et613 33 25 . . . cord-015493-vf4et613 34 1 The the DT cord-015493-vf4et613 34 2 median median JJ cord-015493-vf4et613 34 3 lesion lesion NN cord-015493-vf4et613 34 4 maximum maximum JJ cord-015493-vf4et613 34 5 diameter diameter NN cord-015493-vf4et613 34 6 was be VBD cord-015493-vf4et613 34 7 4 4 CD cord-015493-vf4et613 34 8 cm cm NN cord-015493-vf4et613 34 9 ( ( -LRB- cord-015493-vf4et613 34 10 range range NN cord-015493-vf4et613 34 11 , , , cord-015493-vf4et613 34 12 3 3 CD cord-015493-vf4et613 34 13 - - SYM cord-015493-vf4et613 34 14 5 5 CD cord-015493-vf4et613 34 15 cm cm NN cord-015493-vf4et613 34 16 ) ) -RRB- cord-015493-vf4et613 34 17 . . . cord-015493-vf4et613 35 1 Incision incision NN cord-015493-vf4et613 35 2 and and CC cord-015493-vf4et613 35 3 drainage drainage NN cord-015493-vf4et613 35 4 procedures procedure NNS cord-015493-vf4et613 35 5 were be VBD cord-015493-vf4et613 35 6 performed perform VBN cord-015493-vf4et613 35 7 for for IN cord-015493-vf4et613 35 8 91 91 CD cord-015493-vf4et613 35 9 % % NN cord-015493-vf4et613 35 10 of of IN cord-015493-vf4et613 35 11 episodes episode NNS cord-015493-vf4et613 35 12 with with IN cord-015493-vf4et613 35 13 abscess abscess NN cord-015493-vf4et613 35 14 , , , cord-015493-vf4et613 35 15 furuncles furuncle NNS cord-015493-vf4et613 35 16 , , , cord-015493-vf4et613 35 17 or or CC cord-015493-vf4et613 35 18 carbuncles carbuncle NNS cord-015493-vf4et613 35 19 and and CC cord-015493-vf4et613 35 20 for for IN cord-015493-vf4et613 35 21 66 66 CD cord-015493-vf4et613 35 22 % % NN cord-015493-vf4et613 35 23 of of IN cord-015493-vf4et613 35 24 the the DT cord-015493-vf4et613 35 25 other other JJ cord-015493-vf4et613 35 26 episodes episode NNS cord-015493-vf4et613 35 27 . . . cord-015493-vf4et613 36 1 For for IN cord-015493-vf4et613 36 2 90 90 CD cord-015493-vf4et613 36 3 episodes episode NNS cord-015493-vf4et613 36 4 ( ( -LRB- cord-015493-vf4et613 36 5 32 32 CD cord-015493-vf4et613 36 6 % % NN cord-015493-vf4et613 36 7 ) ) -RRB- cord-015493-vf4et613 36 8 , , , cord-015493-vf4et613 36 9 patients patient NNS cord-015493-vf4et613 36 10 received receive VBD cord-015493-vf4et613 36 11 doxycycline doxycycline NNP cord-015493-vf4et613 36 12 ( ( -LRB- cord-015493-vf4et613 36 13 ) ) -RRB- cord-015493-vf4et613 36 14 or or CC cord-015493-vf4et613 36 15 n n NN cord-015493-vf4et613 36 16 p p NN cord-015493-vf4et613 36 17 87 87 CD cord-015493-vf4et613 36 18 minocycline minocycline NNP cord-015493-vf4et613 36 19 ( ( -LRB- cord-015493-vf4et613 36 20 ) ) -RRB- cord-015493-vf4et613 36 21 , , , cord-015493-vf4et613 36 22 whereas whereas IN cord-015493-vf4et613 36 23 a a DT cord-015493-vf4et613 36 24 b b NN cord-015493-vf4et613 36 25 - - HYPH cord-015493-vf4et613 36 26 lactam lactam NN cord-015493-vf4et613 36 27 n n NN cord-015493-vf4et613 36 28 p p NN cord-015493-vf4et613 36 29 3 3 CD cord-015493-vf4et613 36 30 antibiotic antibiotic NN cord-015493-vf4et613 36 31 was be VBD cord-015493-vf4et613 36 32 provided provide VBN cord-015493-vf4et613 36 33 for for IN cord-015493-vf4et613 36 34 the the DT cord-015493-vf4et613 36 35 remaining remain VBG cord-015493-vf4et613 36 36 episodes episode NNS cord-015493-vf4et613 36 37 . . . cord-015493-vf4et613 37 1 During during IN cord-015493-vf4et613 37 2 the the DT cord-015493-vf4et613 37 3 years year NNS cord-015493-vf4et613 37 4 of of IN cord-015493-vf4et613 37 5 the the DT cord-015493-vf4et613 37 6 study study NN cord-015493-vf4et613 37 7 , , , cord-015493-vf4et613 37 8 94%-96 94%-96 CD cord-015493-vf4et613 37 9 % % NN cord-015493-vf4et613 37 10 of of IN cord-015493-vf4et613 37 11 isolates isolate NNS cord-015493-vf4et613 37 12 were be VBD cord-015493-vf4et613 37 13 found find VBN cord-015493-vf4et613 37 14 to to TO cord-015493-vf4et613 37 15 be be VB cord-015493-vf4et613 37 16 susceptible susceptible JJ cord-015493-vf4et613 37 17 to to IN cord-015493-vf4et613 37 18 tetracycline tetracycline NNP cord-015493-vf4et613 37 19 . . . cord-015493-vf4et613 38 1 Ten ten CD cord-015493-vf4et613 38 2 percent percent NN cord-015493-vf4et613 38 3 of of IN cord-015493-vf4et613 38 4 patients patient NNS cord-015493-vf4et613 38 5 experienced experience VBD cord-015493-vf4et613 38 6 treatment treatment NN cord-015493-vf4et613 38 7 failure failure NN cord-015493-vf4et613 38 8 , , , cord-015493-vf4et613 38 9 with with IN cord-015493-vf4et613 38 10 23 23 CD cord-015493-vf4et613 38 11 requiring require VBG cord-015493-vf4et613 38 12 a a DT cord-015493-vf4et613 38 13 second second JJ cord-015493-vf4et613 38 14 incision incision NN cord-015493-vf4et613 38 15 and and CC cord-015493-vf4et613 38 16 drainage drainage NN cord-015493-vf4et613 38 17 procedure procedure NN cord-015493-vf4et613 38 18 and and CC cord-015493-vf4et613 38 19 5 5 CD cord-015493-vf4et613 38 20 requiring require VBG cord-015493-vf4et613 38 21 hospital hospital NN cord-015493-vf4et613 38 22 admission admission NN cord-015493-vf4et613 38 23 . . . cord-015493-vf4et613 39 1 In in IN cord-015493-vf4et613 39 2 contrast contrast NN cord-015493-vf4et613 39 3 to to IN cord-015493-vf4et613 39 4 previous previous JJ cord-015493-vf4et613 39 5 reports report NNS cord-015493-vf4et613 39 6 , , , cord-015493-vf4et613 39 7 the the DT cord-015493-vf4et613 39 8 size size NN cord-015493-vf4et613 39 9 of of IN cord-015493-vf4et613 39 10 the the DT cord-015493-vf4et613 39 11 lesion lesion NN cord-015493-vf4et613 39 12 was be VBD cord-015493-vf4et613 39 13 not not RB cord-015493-vf4et613 39 14 associated associate VBN cord-015493-vf4et613 39 15 with with IN cord-015493-vf4et613 39 16 outcome outcome NN cord-015493-vf4et613 39 17 . . . cord-015493-vf4et613 40 1 Logistic logistic JJ cord-015493-vf4et613 40 2 regression regression NN cord-015493-vf4et613 40 3 analysis analysis NN cord-015493-vf4et613 40 4 identified identify VBD cord-015493-vf4et613 40 5 receipt receipt NN cord-015493-vf4et613 40 6 of of IN cord-015493-vf4et613 40 7 a a DT cord-015493-vf4et613 40 8 b b NN cord-015493-vf4et613 40 9 - - HYPH cord-015493-vf4et613 40 10 lactam lactam NNS cord-015493-vf4et613 40 11 antibiotic antibiotic NN cord-015493-vf4et613 40 12 as as IN cord-015493-vf4et613 40 13 the the DT cord-015493-vf4et613 40 14 only only JJ cord-015493-vf4et613 40 15 clinical clinical JJ cord-015493-vf4et613 40 16 predictor predictor NN cord-015493-vf4et613 40 17 of of IN cord-015493-vf4et613 40 18 treatment treatment NN cord-015493-vf4et613 40 19 failure failure NN cord-015493-vf4et613 40 20 ( ( -LRB- cord-015493-vf4et613 40 21 adjusted adjust VBN cord-015493-vf4et613 40 22 OR or CC cord-015493-vf4et613 40 23 , , , cord-015493-vf4et613 40 24 3.94 3.94 CD cord-015493-vf4et613 40 25 ; ; : cord-015493-vf4et613 40 26 95 95 CD cord-015493-vf4et613 40 27 % % NN cord-015493-vf4et613 40 28 CI ci NN cord-015493-vf4et613 40 29 , , , cord-015493-vf4et613 40 30 1.28 1.28 CD cord-015493-vf4et613 40 31 - - SYM cord-015493-vf4et613 40 32 12.15 12.15 CD cord-015493-vf4et613 40 33 ) ) -RRB- cord-015493-vf4et613 40 34 . . . cord-015493-vf4et613 41 1 Subgroup subgroup NN cord-015493-vf4et613 41 2 analysis analysis NN cord-015493-vf4et613 41 3 that that WDT cord-015493-vf4et613 41 4 included include VBD cord-015493-vf4et613 41 5 only only RB cord-015493-vf4et613 41 6 the the DT cord-015493-vf4et613 41 7 225 225 CD cord-015493-vf4et613 41 8 episodes episode NNS cord-015493-vf4et613 41 9 in in IN cord-015493-vf4et613 41 10 which which WDT cord-015493-vf4et613 41 11 incision incision NN cord-015493-vf4et613 41 12 and and CC cord-015493-vf4et613 41 13 drainage drainage NN cord-015493-vf4et613 41 14 were be VBD cord-015493-vf4et613 41 15 performed perform VBN cord-015493-vf4et613 41 16 at at IN cord-015493-vf4et613 41 17 presentation presentation NN cord-015493-vf4et613 41 18 confirmed confirm VBD cord-015493-vf4et613 41 19 that that IN cord-015493-vf4et613 41 20 blactam blactam NNP cord-015493-vf4et613 41 21 antibiotic antibiotic JJ cord-015493-vf4et613 41 22 therapy therapy NN cord-015493-vf4et613 41 23 was be VBD cord-015493-vf4et613 41 24 significantly significantly RB cord-015493-vf4et613 41 25 associated associate VBN cord-015493-vf4et613 41 26 with with IN cord-015493-vf4et613 41 27 treatment treatment NN cord-015493-vf4et613 41 28 failure failure NN cord-015493-vf4et613 41 29 . . . cord-015493-vf4et613 42 1 These these DT cord-015493-vf4et613 42 2 results result NNS cord-015493-vf4et613 42 3 are be VBP cord-015493-vf4et613 42 4 consistent consistent JJ cord-015493-vf4et613 42 5 with with IN cord-015493-vf4et613 42 6 those those DT cord-015493-vf4et613 42 7 of of IN cord-015493-vf4et613 42 8 several several JJ cord-015493-vf4et613 42 9 other other JJ cord-015493-vf4et613 42 10 recent recent JJ cord-015493-vf4et613 42 11 studies study NNS cord-015493-vf4et613 42 12 that that WDT cord-015493-vf4et613 42 13 have have VBP cord-015493-vf4et613 42 14 found find VBN cord-015493-vf4et613 42 15 that that IN cord-015493-vf4et613 42 16 administration administration NN cord-015493-vf4et613 42 17 of of IN cord-015493-vf4et613 42 18 an an DT cord-015493-vf4et613 42 19 antibiotic antibiotic NN cord-015493-vf4et613 42 20 that that WDT cord-015493-vf4et613 42 21 inhibits inhibit VBZ cord-015493-vf4et613 42 22 the the DT cord-015493-vf4et613 42 23 growth growth NN cord-015493-vf4et613 42 24 of of IN cord-015493-vf4et613 42 25 MRSA MRSA NNP cord-015493-vf4et613 42 26 improves improve VBZ cord-015493-vf4et613 42 27 outcomes outcome NNS cord-015493-vf4et613 42 28 , , , cord-015493-vf4et613 42 29 even even RB cord-015493-vf4et613 42 30 in in IN cord-015493-vf4et613 42 31 patients patient NNS cord-015493-vf4et613 42 32 who who WP cord-015493-vf4et613 42 33 have have VBP cord-015493-vf4et613 42 34 undergone undergo VBN cord-015493-vf4et613 42 35 incision incision NN cord-015493-vf4et613 42 36 and and CC cord-015493-vf4et613 42 37 drainage drainage NN cord-015493-vf4et613 42 38 . . . cord-015493-vf4et613 43 1 For for IN cord-015493-vf4et613 43 2 example example NN cord-015493-vf4et613 43 3 , , , cord-015493-vf4et613 43 4 in in IN cord-015493-vf4et613 43 5 a a DT cord-015493-vf4et613 43 6 similar similar JJ cord-015493-vf4et613 43 7 retrospective retrospective JJ cord-015493-vf4et613 43 8 study study NN cord-015493-vf4et613 43 9 of of IN cord-015493-vf4et613 43 10 531 531 CD cord-015493-vf4et613 43 11 episodes episode NNS cord-015493-vf4et613 43 12 of of IN cord-015493-vf4et613 43 13 community community NN cord-015493-vf4et613 43 14 - - HYPH cord-015493-vf4et613 43 15 acquired acquire VBN cord-015493-vf4et613 43 16 MRSA MRSA NNP cord-015493-vf4et613 43 17 SSTI SSTI NNP cord-015493-vf4et613 43 18 , , , cord-015493-vf4et613 43 19 most most JJS cord-015493-vf4et613 43 20 of of IN cord-015493-vf4et613 43 21 which which WDT cord-015493-vf4et613 43 22 were be VBD cord-015493-vf4et613 43 23 treated treat VBN cord-015493-vf4et613 43 24 with with IN cord-015493-vf4et613 43 25 incision incision NN cord-015493-vf4et613 43 26 and and CC cord-015493-vf4et613 43 27 drainage drainage NN cord-015493-vf4et613 43 28 , , , cord-015493-vf4et613 43 29 Ruhe Ruhe NNP cord-015493-vf4et613 43 30 et et NNP cord-015493-vf4et613 43 31 al al NNP cord-015493-vf4et613 43 32 . . . cord-015493-vf4et613 44 1 [ [ -LRB- cord-015493-vf4et613 44 2 1 1 LS cord-015493-vf4et613 44 3 ] ] -RRB- cord-015493-vf4et613 44 4 found find VBD cord-015493-vf4et613 44 5 treatment treatment NN cord-015493-vf4et613 44 6 failure failure NN cord-015493-vf4et613 44 7 rates rate NNS cord-015493-vf4et613 44 8 of of IN cord-015493-vf4et613 44 9 5 5 CD cord-015493-vf4et613 44 10 % % NN cord-015493-vf4et613 44 11 among among IN cord-015493-vf4et613 44 12 patients patient NNS cord-015493-vf4et613 44 13 who who WP cord-015493-vf4et613 44 14 received receive VBD cord-015493-vf4et613 44 15 an an DT cord-015493-vf4et613 44 16 antibiotic antibiotic JJ cord-015493-vf4et613 44 17 active active JJ cord-015493-vf4et613 44 18 against against IN cord-015493-vf4et613 44 19 the the DT cord-015493-vf4et613 44 20 pathogen pathogen NN cord-015493-vf4et613 44 21 and and CC cord-015493-vf4et613 44 22 13 13 CD cord-015493-vf4et613 44 23 % % NN cord-015493-vf4et613 44 24 among among IN cord-015493-vf4et613 44 25 those those DT cord-015493-vf4et613 44 26 who who WP cord-015493-vf4et613 44 27 received receive VBD cord-015493-vf4et613 44 28 an an DT cord-015493-vf4et613 44 29 antibiotic antibiotic NN cord-015493-vf4et613 44 30 without without IN cord-015493-vf4et613 44 31 activity activity NN cord-015493-vf4et613 44 32 ( ( -LRB- cord-015493-vf4et613 44 33 ) ) -RRB- cord-015493-vf4et613 44 34 . . . cord-015493-vf4et613 45 1 There there EX cord-015493-vf4et613 45 2 has have VBZ cord-015493-vf4et613 45 3 been be VBN cord-015493-vf4et613 45 4 little little JJ cord-015493-vf4et613 45 5 P p NN cord-015493-vf4et613 45 6 p p NN cord-015493-vf4et613 45 7 .01 .01 CD cord-015493-vf4et613 45 8 study study NN cord-015493-vf4et613 45 9 of of IN cord-015493-vf4et613 45 10 which which WDT cord-015493-vf4et613 45 11 antibiotic antibiotic JJ cord-015493-vf4et613 45 12 with with IN cord-015493-vf4et613 45 13 activity activity NN cord-015493-vf4et613 45 14 against against IN cord-015493-vf4et613 45 15 MRSA MRSA NNP cord-015493-vf4et613 45 16 is be VBZ cord-015493-vf4et613 45 17 optimum optimum JJ cord-015493-vf4et613 45 18 . . . cord-015493-vf4et613 46 1 Although although IN cord-015493-vf4et613 46 2 Ruhe Ruhe NNP cord-015493-vf4et613 46 3 and and CC cord-015493-vf4et613 46 4 colleagues colleague NNS cord-015493-vf4et613 46 5 provide provide VBP cord-015493-vf4et613 46 6 evidence evidence NN cord-015493-vf4et613 46 7 of of IN cord-015493-vf4et613 46 8 the the DT cord-015493-vf4et613 46 9 benefit benefit NN cord-015493-vf4et613 46 10 of of IN cord-015493-vf4et613 46 11 doxycyline doxycyline NN cord-015493-vf4et613 46 12 for for IN cord-015493-vf4et613 46 13 the the DT cord-015493-vf4et613 46 14 treatment treatment NN cord-015493-vf4et613 46 15 of of IN cord-015493-vf4et613 46 16 SSTI SSTI NNP cord-015493-vf4et613 46 17 due due IN cord-015493-vf4et613 46 18 to to IN cord-015493-vf4et613 46 19 antibioticsusceptible antibioticsusceptible JJ cord-015493-vf4et613 46 20 MRSA MRSA NNP cord-015493-vf4et613 46 21 , , , cord-015493-vf4et613 46 22 alternative alternative JJ cord-015493-vf4et613 46 23 antibiotic antibiotic JJ cord-015493-vf4et613 46 24 choices choice NNS cord-015493-vf4et613 46 25 may may MD cord-015493-vf4et613 46 26 be be VB cord-015493-vf4et613 46 27 considered consider VBN cord-015493-vf4et613 46 28 . . . cord-015493-vf4et613 47 1 In in IN cord-015493-vf4et613 47 2 a a DT cord-015493-vf4et613 47 3 small small JJ cord-015493-vf4et613 47 4 , , , cord-015493-vf4et613 47 5 prospective prospective JJ cord-015493-vf4et613 47 6 , , , cord-015493-vf4et613 47 7 open open JJ cord-015493-vf4et613 47 8 - - HYPH cord-015493-vf4et613 47 9 label label NN cord-015493-vf4et613 47 10 trial trial NN cord-015493-vf4et613 47 11 , , , cord-015493-vf4et613 47 12 outpatients outpatient NNS cord-015493-vf4et613 47 13 with with IN cord-015493-vf4et613 47 14 SSTI SSTI NNP cord-015493-vf4et613 47 15 were be VBD cord-015493-vf4et613 47 16 randomized randomize VBN cord-015493-vf4et613 47 17 to to TO cord-015493-vf4et613 47 18 receive receive VB cord-015493-vf4et613 47 19 treatment treatment NN cord-015493-vf4et613 47 20 with with IN cord-015493-vf4et613 47 21 either either CC cord-015493-vf4et613 47 22 trimethoprim trimethoprim NNP cord-015493-vf4et613 47 23 - - HYPH cord-015493-vf4et613 47 24 sulfamethoxazole sulfamethoxazole NNP cord-015493-vf4et613 47 25 ( ( -LRB- cord-015493-vf4et613 47 26 160 160 CD cord-015493-vf4et613 47 27 mg/800 mg/800 NNP cord-015493-vf4et613 47 28 mg mg NNP cord-015493-vf4et613 47 29 ) ) -RRB- cord-015493-vf4et613 47 30 or or CC cord-015493-vf4et613 47 31 doxycycline doxycycline NNP cord-015493-vf4et613 47 32 ( ( -LRB- cord-015493-vf4et613 47 33 100 100 CD cord-015493-vf4et613 47 34 mg mg NNP cord-015493-vf4et613 47 35 ) ) -RRB- cord-015493-vf4et613 47 36 , , , cord-015493-vf4et613 47 37 each each DT cord-015493-vf4et613 47 38 given give VBN cord-015493-vf4et613 47 39 twice twice RB cord-015493-vf4et613 47 40 daily daily RB cord-015493-vf4et613 47 41 for for IN cord-015493-vf4et613 47 42 7 7 CD cord-015493-vf4et613 47 43 days day NNS cord-015493-vf4et613 47 44 [ [ -LRB- cord-015493-vf4et613 47 45 2 2 CD cord-015493-vf4et613 47 46 ] ] -RRB- cord-015493-vf4et613 47 47 . . . cord-015493-vf4et613 48 1 Although although IN cord-015493-vf4et613 48 2 there there EX cord-015493-vf4et613 48 3 was be VBD cord-015493-vf4et613 48 4 not not RB cord-015493-vf4et613 48 5 a a DT cord-015493-vf4et613 48 6 statistically statistically RB cord-015493-vf4et613 48 7 significant significant JJ cord-015493-vf4et613 48 8 difference difference NN cord-015493-vf4et613 48 9 in in IN cord-015493-vf4et613 48 10 outcome outcome NN cord-015493-vf4et613 48 11 , , , cord-015493-vf4et613 48 12 all all DT cord-015493-vf4et613 48 13 3 3 CD cord-015493-vf4et613 48 14 treatment treatment NN cord-015493-vf4et613 48 15 failures failure NNS cord-015493-vf4et613 48 16 occurred occur VBD cord-015493-vf4et613 48 17 among among IN cord-015493-vf4et613 48 18 the the DT cord-015493-vf4et613 48 19 14 14 CD cord-015493-vf4et613 48 20 patients patient NNS cord-015493-vf4et613 48 21 who who WP cord-015493-vf4et613 48 22 received receive VBD cord-015493-vf4et613 48 23 trimethoprim trimethoprim NNP cord-015493-vf4et613 48 24 - - HYPH cord-015493-vf4et613 48 25 sulfamethoxazole sulfamethoxazole NNP cord-015493-vf4et613 48 26 , , , cord-015493-vf4et613 48 27 for for IN cord-015493-vf4et613 48 28 a a DT cord-015493-vf4et613 48 29 treat treat NN cord-015493-vf4et613 48 30 - - HYPH cord-015493-vf4et613 48 31 ment ment NN cord-015493-vf4et613 48 32 failure failure NN cord-015493-vf4et613 48 33 rate rate NN cord-015493-vf4et613 48 34 of of IN cord-015493-vf4et613 48 35 21 21 CD cord-015493-vf4et613 48 36 % % NN cord-015493-vf4et613 48 37 . . . cord-015493-vf4et613 49 1 The the DT cord-015493-vf4et613 49 2 optimal optimal JJ cord-015493-vf4et613 49 3 antibiotic antibiotic JJ cord-015493-vf4et613 49 4 choice choice NN cord-015493-vf4et613 49 5 thus thus RB cord-015493-vf4et613 49 6 awaits await VBZ cord-015493-vf4et613 49 7 results result NNS cord-015493-vf4et613 49 8 of of IN cord-015493-vf4et613 49 9 future future JJ cord-015493-vf4et613 49 10 clinical clinical JJ cord-015493-vf4et613 49 11 trials trial NNS cord-015493-vf4et613 49 12 with with IN cord-015493-vf4et613 49 13 sample sample NN cord-015493-vf4et613 49 14 sizes size NNS cord-015493-vf4et613 49 15 sufficient sufficient JJ cord-015493-vf4et613 49 16 to to TO cord-015493-vf4et613 49 17 allow allow VB cord-015493-vf4et613 49 18 for for IN cord-015493-vf4et613 49 19 definitive definitive JJ cord-015493-vf4et613 49 20 answers answer NNS cord-015493-vf4et613 49 21 . . . cord-015493-vf4et613 50 1 One one CD cord-015493-vf4et613 50 2 problem problem NN cord-015493-vf4et613 50 3 , , , cord-015493-vf4et613 50 4 however however RB cord-015493-vf4et613 50 5 , , , cord-015493-vf4et613 50 6 is be VBZ cord-015493-vf4et613 50 7 that that IN cord-015493-vf4et613 50 8 community community NN cord-015493-vf4et613 50 9 - - HYPH cord-015493-vf4et613 50 10 acquired acquire VBN cord-015493-vf4et613 50 11 MRSA MRSA NNP cord-015493-vf4et613 50 12 is be VBZ cord-015493-vf4et613 50 13 a a DT cord-015493-vf4et613 50 14 moving move VBG cord-015493-vf4et613 50 15 target target NN cord-015493-vf4et613 50 16 , , , cord-015493-vf4et613 50 17 and and CC cord-015493-vf4et613 50 18 that that IN cord-015493-vf4et613 50 19 , , , cord-015493-vf4et613 50 20 in in IN cord-015493-vf4et613 50 21 some some DT cord-015493-vf4et613 50 22 geographical geographical JJ cord-015493-vf4et613 50 23 areas area NNS cord-015493-vf4et613 50 24 , , , cord-015493-vf4et613 50 25 it -PRON- PRP cord-015493-vf4et613 50 26 has have VBZ cord-015493-vf4et613 50 27 acquired acquire VBN cord-015493-vf4et613 50 28 additional additional JJ cord-015493-vf4et613 50 29 antibiotic antibiotic JJ cord-015493-vf4et613 50 30 - - HYPH cord-015493-vf4et613 50 31 resistance resistance NN cord-015493-vf4et613 50 32 determinants determinant NNS cord-015493-vf4et613 50 33 . . . cord-015493-vf4et613 51 1 An an DT cord-015493-vf4et613 51 2 additional additional JJ cord-015493-vf4et613 51 3 factor factor NN cord-015493-vf4et613 51 4 that that WDT cord-015493-vf4et613 51 5 must must MD cord-015493-vf4et613 51 6 be be VB cord-015493-vf4et613 51 7 considered consider VBN cord-015493-vf4et613 51 8 in in IN cord-015493-vf4et613 51 9 future future JJ cord-015493-vf4et613 51 10 trials trial NNS cord-015493-vf4et613 51 11 is be VBZ cord-015493-vf4et613 51 12 the the DT cord-015493-vf4et613 51 13 potential potential JJ cord-015493-vf4et613 51 14 benefit benefit NN cord-015493-vf4et613 51 15 of of IN cord-015493-vf4et613 51 16 effective effective JJ cord-015493-vf4et613 51 17 antibiotic antibiotic JJ cord-015493-vf4et613 51 18 therapy therapy NN cord-015493-vf4et613 51 19 on on IN cord-015493-vf4et613 51 20 the the DT cord-015493-vf4et613 51 21 prevention prevention NN cord-015493-vf4et613 51 22 or or CC cord-015493-vf4et613 51 23 delay delay NN cord-015493-vf4et613 51 24 of of IN cord-015493-vf4et613 51 25 recurrences recurrence NNS cord-015493-vf4et613 51 26 of of IN cord-015493-vf4et613 51 27 infection infection NN cord-015493-vf4et613 51 28 . . . cord-015493-vf4et613 52 1 Identification identification NN cord-015493-vf4et613 52 2 of of IN cord-015493-vf4et613 52 3 a a DT cord-015493-vf4et613 52 4 third third JJ cord-015493-vf4et613 52 5 human human JJ cord-015493-vf4et613 52 6 polyomavirus polyomavirus JJ cord-015493-vf4et613 52 7 Characterization characterization NN cord-015493-vf4et613 52 8 of of IN cord-015493-vf4et613 52 9 a a DT cord-015493-vf4et613 52 10 newly newly RB cord-015493-vf4et613 52 11 identified identify VBN cord-015493-vf4et613 52 12 human human JJ cord-015493-vf4et613 52 13 rhinovirus rhinovirus NN cord-015493-vf4et613 52 14 , , , cord-015493-vf4et613 52 15 HRV HRV NNP cord-015493-vf4et613 52 16 - - HYPH cord-015493-vf4et613 52 17 QPM QPM NNP cord-015493-vf4et613 52 18 , , , cord-015493-vf4et613 52 19 discovered discover VBN cord-015493-vf4et613 52 20 in in IN cord-015493-vf4et613 52 21 infants infant NNS cord-015493-vf4et613 52 22 with with IN cord-015493-vf4et613 52 23 bronchiolitis bronchiolitis NN cord-015493-vf4et613 52 24 Community community NN cord-015493-vf4et613 52 25 - - HYPH cord-015493-vf4et613 52 26 onset onset NN cord-015493-vf4et613 52 27 methicillin methicillin NN cord-015493-vf4et613 52 28 - - HYPH cord-015493-vf4et613 52 29 resistant resistant JJ cord-015493-vf4et613 52 30 Staphylococcus Staphylococcus NNP cord-015493-vf4et613 52 31 aureus aureus NN cord-015493-vf4et613 52 32 skin skin NN cord-015493-vf4et613 52 33 and and CC cord-015493-vf4et613 52 34 soft soft JJ cord-015493-vf4et613 52 35 - - HYPH cord-015493-vf4et613 52 36 tissue tissue NN cord-015493-vf4et613 52 37 infections infection NNS cord-015493-vf4et613 52 38 : : : cord-015493-vf4et613 52 39 impact impact NN cord-015493-vf4et613 52 40 of of IN cord-015493-vf4et613 52 41 antimicrobial antimicrobial JJ cord-015493-vf4et613 52 42 therapy therapy NN cord-015493-vf4et613 52 43 on on IN cord-015493-vf4et613 52 44 outcome outcome NN cord-015493-vf4et613 52 45 Prospective prospective JJ cord-015493-vf4et613 52 46 randomized randomized JJ cord-015493-vf4et613 52 47 trial trial NN cord-015493-vf4et613 52 48 of of IN cord-015493-vf4et613 52 49 empiric empiric JJ cord-015493-vf4et613 52 50 therapy therapy NN cord-015493-vf4et613 52 51 with with IN cord-015493-vf4et613 52 52 trimethoprim trimethoprim NNP cord-015493-vf4et613 52 53 - - HYPH cord-015493-vf4et613 52 54 sulfamethoxazole sulfamethoxazole NNP cord-015493-vf4et613 52 55 or or CC cord-015493-vf4et613 52 56 doxycycline doxycycline NN cord-015493-vf4et613 52 57 for for IN cord-015493-vf4et613 52 58 outpatient outpatient NN cord-015493-vf4et613 52 59 skin skin NN cord-015493-vf4et613 52 60 and and CC cord-015493-vf4et613 52 61 soft soft JJ cord-015493-vf4et613 52 62 tissue tissue NN cord-015493-vf4et613 52 63 infections infection NNS cord-015493-vf4et613 52 64 in in IN cord-015493-vf4et613 52 65 an an DT cord-015493-vf4et613 52 66 area area NN cord-015493-vf4et613 52 67 of of IN cord-015493-vf4et613 52 68 high high JJ cord-015493-vf4et613 52 69 prevalence prevalence NN cord-015493-vf4et613 52 70 of of IN cord-015493-vf4et613 52 71 methicillin methicillin NN cord-015493-vf4et613 52 72 - - HYPH cord-015493-vf4et613 52 73 resistant resistant JJ cord-015493-vf4et613 52 74 Staphylococcus Staphylococcus NNP cord-015493-vf4et613 52 75 aureus aureus NN cord-015493-vf4et613 53 1 In in IN cord-015493-vf4et613 53 2 the the DT cord-015493-vf4et613 53 3 literature literature NN cord-015493-vf4et613 53 4 : : : cord-015493-vf4et613 53 5 Chlamydia Chlamydia NNP cord-015493-vf4et613 53 6 trachomatis trachomatis NN cord-015493-vf4et613 53 7 finds find VBZ cord-015493-vf4et613 53 8 a a DT cord-015493-vf4et613 53 9 way way NN cord-015493-vf4et613 53 10 to to TO cord-015493-vf4et613 53 11 evade evade VB cord-015493-vf4et613 53 12 diagnosis diagnosis NN cord-015493-vf4et613 53 13 Screening screening NN cord-015493-vf4et613 53 14 for for IN cord-015493-vf4et613 53 15 chlamydial chlamydial JJ cord-015493-vf4et613 53 16 infection infection NN cord-015493-vf4et613 53 17 : : : cord-015493-vf4et613 53 18 US US NNP cord-015493-vf4et613 53 19 Preventive Preventive NNP cord-015493-vf4et613 53 20 Services Services NNPS cord-015493-vf4et613 53 21 Task Task NNP cord-015493-vf4et613 53 22 Force Force NNP cord-015493-vf4et613 53 23 Recommendation Recommendation NNP cord-015493-vf4et613 53 24 Statement Statement NNP cord-015493-vf4et613 54 1 The the DT cord-015493-vf4et613 54 2 most most RBS cord-015493-vf4et613 54 3 frequently frequently RB cord-015493-vf4et613 54 4 reported report VBN cord-015493-vf4et613 54 5 notifiable notifiable JJ cord-015493-vf4et613 54 6 disease disease NN cord-015493-vf4et613 54 7 in in IN cord-015493-vf4et613 54 8 the the DT cord-015493-vf4et613 54 9 United United NNP cord-015493-vf4et613 54 10 States States NNP cord-015493-vf4et613 54 11 is be VBZ cord-015493-vf4et613 54 12 infection infection NN cord-015493-vf4et613 54 13 with with IN cord-015493-vf4et613 54 14 Chlamydia Chlamydia NNP cord-015493-vf4et613 54 15 trachomatis trachomatis NN cord-015493-vf4et613 54 16 , , , cord-015493-vf4et613 54 17 with with IN cord-015493-vf4et613 54 18 Neisseria Neisseria NNP cord-015493-vf4et613 54 19 gonorrhoeae gonorrhoeae NNP cord-015493-vf4et613 54 20 infection infection NN cord-015493-vf4et613 54 21 placing place VBG cord-015493-vf4et613 54 22 second second RB cord-015493-vf4et613 54 23 . . . cord-015493-vf4et613 55 1 Urine urine NN cord-015493-vf4et613 55 2 specimens specimen NNS cord-015493-vf4et613 55 3 were be VBD cord-015493-vf4et613 55 4 obtained obtain VBN cord-015493-vf4et613 55 5 from from IN cord-015493-vf4et613 55 6 6632 6632 CD cord-015493-vf4et613 55 7 participants participant NNS cord-015493-vf4et613 55 8 ( ( -LRB- cord-015493-vf4et613 55 9 age age NN cord-015493-vf4et613 55 10 , , , cord-015493-vf4et613 55 11 14 14 CD cord-015493-vf4et613 55 12 - - SYM cord-015493-vf4et613 55 13 39 39 CD cord-015493-vf4et613 55 14 years year NNS cord-015493-vf4et613 55 15 ) ) -RRB- cord-015493-vf4et613 55 16 during during IN cord-015493-vf4et613 55 17 the the DT cord-015493-vf4et613 55 18 period period NN cord-015493-vf4et613 55 19 1999 1999 CD cord-015493-vf4et613 55 20 - - SYM cord-015493-vf4et613 55 21 2002 2002 CD cord-015493-vf4et613 55 22 in in IN cord-015493-vf4et613 55 23 the the DT cord-015493-vf4et613 55 24 National National NNP cord-015493-vf4et613 55 25 Health Health NNP cord-015493-vf4et613 55 26 and and CC cord-015493-vf4et613 55 27 Examination Examination NNP cord-015493-vf4et613 55 28 Survey Survey NNP cord-015493-vf4et613 55 29 ; ; , cord-015493-vf4et613 55 30 ligase ligase NN cord-015493-vf4et613 55 31 chain chain NN cord-015493-vf4et613 55 32 reaction reaction NN cord-015493-vf4et613 55 33 detected detect VBD cord-015493-vf4et613 55 34 a a DT cord-015493-vf4et613 55 35 prevalence prevalence NN cord-015493-vf4et613 55 36 of of IN cord-015493-vf4et613 55 37 chlamydial chlamydial JJ cord-015493-vf4et613 55 38 infection infection NN cord-015493-vf4et613 55 39 of of IN cord-015493-vf4et613 55 40 2.2 2.2 CD cord-015493-vf4et613 55 41 % % NN cord-015493-vf4et613 55 42 ( ( -LRB- cord-015493-vf4et613 55 43 95 95 CD cord-015493-vf4et613 55 44 % % NN cord-015493-vf4et613 55 45 CI CI NNP cord-015493-vf4et613 55 46 , , , cord-015493-vf4et613 55 47 1.8%-2.8 1.8%-2.8 CD cord-015493-vf4et613 55 48 % % NN cord-015493-vf4et613 55 49 ) ) -RRB- cord-015493-vf4et613 55 50 and and CC cord-015493-vf4et613 55 51 a a DT cord-015493-vf4et613 55 52 prevalence prevalence NN cord-015493-vf4et613 55 53 of of IN cord-015493-vf4et613 55 54 gonorrheal gonorrheal JJ cord-015493-vf4et613 55 55 infection infection NN cord-015493-vf4et613 55 56 of of IN cord-015493-vf4et613 55 57 0.24 0.24 CD cord-015493-vf4et613 55 58 % % NN cord-015493-vf4et613 55 59 ( ( -LRB- cord-015493-vf4et613 55 60 95 95 CD cord-015493-vf4et613 55 61 % % NN cord-015493-vf4et613 55 62 CI CI NNP cord-015493-vf4et613 55 63 , , , cord-015493-vf4et613 55 64 0.16%-0.38 0.16%-0.38 CD cord-015493-vf4et613 55 65 % % NN cord-015493-vf4et613 55 66 ) ) -RRB- cord-015493-vf4et613 55 67 . . . cord-015493-vf4et613 56 1 The the DT cord-015493-vf4et613 56 2 prevalence prevalence NN cord-015493-vf4et613 56 3 of of IN cord-015493-vf4et613 56 4 chlamydial chlamydial JJ cord-015493-vf4et613 56 5 infection infection NN cord-015493-vf4et613 56 6 was be VBD cord-015493-vf4et613 56 7 similar similar JJ cord-015493-vf4et613 56 8 in in IN cord-015493-vf4et613 56 9 male male JJ cord-015493-vf4et613 56 10 and and CC cord-015493-vf4et613 56 11 female female JJ cord-015493-vf4et613 56 12 subjects subject NNS cord-015493-vf4et613 56 13 but but CC cord-015493-vf4et613 56 14 peaked peak VBD cord-015493-vf4et613 56 15 at at IN cord-015493-vf4et613 56 16 the the DT cord-015493-vf4et613 56 17 ages age NNS cord-015493-vf4et613 56 18 of of IN cord-015493-vf4et613 56 19 14 14 CD cord-015493-vf4et613 56 20 - - SYM cord-015493-vf4et613 56 21 19 19 CD cord-015493-vf4et613 56 22 years year NNS cord-015493-vf4et613 56 23 in in IN cord-015493-vf4et613 56 24 female female JJ cord-015493-vf4et613 56 25 subjects subject NNS cord-015493-vf4et613 56 26 and and CC cord-015493-vf4et613 56 27 14 14 CD cord-015493-vf4et613 56 28 - - SYM cord-015493-vf4et613 56 29 29 29 CD cord-015493-vf4et613 56 30 years year NNS cord-015493-vf4et613 56 31 in in IN cord-015493-vf4et613 56 32 male male JJ cord-015493-vf4et613 56 33 subjects subject NNS cord-015493-vf4et613 56 34 . . . cord-015493-vf4et613 57 1 The the DT cord-015493-vf4et613 57 2 prevalence prevalence NN cord-015493-vf4et613 57 3 was be VBD cord-015493-vf4et613 57 4 higher high JJR cord-015493-vf4et613 57 5 among among IN cord-015493-vf4et613 57 6 non non JJ cord-015493-vf4et613 57 7 - - JJ cord-015493-vf4et613 57 8 Hispanic hispanic JJ cord-015493-vf4et613 57 9 black black JJ cord-015493-vf4et613 57 10 sub sub NN cord-015493-vf4et613 57 11 - - JJ cord-015493-vf4et613 57 12 jects ject NNS cord-015493-vf4et613 57 13 ( ( -LRB- cord-015493-vf4et613 57 14 6.4 6.4 CD cord-015493-vf4et613 57 15 % % NN cord-015493-vf4et613 57 16 ) ) -RRB- cord-015493-vf4et613 57 17 than than IN cord-015493-vf4et613 57 18 among among IN cord-015493-vf4et613 57 19 non non JJ cord-015493-vf4et613 57 20 - - JJ cord-015493-vf4et613 57 21 Hispanic hispanic JJ cord-015493-vf4et613 57 22 white white JJ cord-015493-vf4et613 57 23 subjects subject NNS cord-015493-vf4et613 57 24 ( ( -LRB- cord-015493-vf4et613 57 25 1.5 1.5 CD cord-015493-vf4et613 57 26 % % NN cord-015493-vf4et613 57 27 ) ) -RRB- cord-015493-vf4et613 57 28 . . . cord-015493-vf4et613 58 1 The the DT cord-015493-vf4et613 58 2 prevalence prevalence NN cord-015493-vf4et613 58 3 of of IN cord-015493-vf4et613 58 4 gonorrheal gonorrheal NN cord-015493-vf4et613 58 5 infection infection NN cord-015493-vf4et613 58 6 was be VBD cord-015493-vf4et613 58 7 also also RB cord-015493-vf4et613 58 8 higher high JJR cord-015493-vf4et613 58 9 in in IN cord-015493-vf4et613 58 10 non non JJ cord-015493-vf4et613 58 11 - - JJ cord-015493-vf4et613 58 12 Hispanic hispanic JJ cord-015493-vf4et613 58 13 blacks black NNS cord-015493-vf4et613 58 14 ( ( -LRB- cord-015493-vf4et613 58 15 1.2 1.2 CD cord-015493-vf4et613 58 16 % % NN cord-015493-vf4et613 58 17 vs. vs. CC cord-015493-vf4et613 58 18 0.07 0.07 CD cord-015493-vf4et613 58 19 % % NN cord-015493-vf4et613 58 20 ) ) -RRB- cord-015493-vf4et613 58 21 . . . cord-015493-vf4et613 59 1 Forty forty CD cord-015493-vf4et613 59 2 - - HYPH cord-015493-vf4et613 59 3 six six CD cord-015493-vf4et613 59 4 percent percent NN cord-015493-vf4et613 59 5 of of IN cord-015493-vf4et613 59 6 individuals individual NNS cord-015493-vf4et613 59 7 with with IN cord-015493-vf4et613 59 8 gonorrheal gonorrheal JJ cord-015493-vf4et613 59 9 infection infection NN cord-015493-vf4et613 59 10 were be VBD cord-015493-vf4et613 59 11 coinfected coinfecte VBN cord-015493-vf4et613 59 12 with with IN cord-015493-vf4et613 59 13 C. C. NNP cord-015493-vf4et613 59 14 trachomatis trachomatis NN cord-015493-vf4et613 59 15 . . . cord-015493-vf4et613 60 1 It -PRON- PRP cord-015493-vf4et613 60 2 should should MD cord-015493-vf4et613 60 3 be be VB cord-015493-vf4et613 60 4 noted note VBN cord-015493-vf4et613 60 5 that that IN cord-015493-vf4et613 60 6 the the DT cord-015493-vf4et613 60 7 test test NN cord-015493-vf4et613 60 8 used use VBN cord-015493-vf4et613 60 9 in in IN cord-015493-vf4et613 60 10 this this DT cord-015493-vf4et613 60 11 survey survey NN cord-015493-vf4et613 60 12 targets target VBZ cord-015493-vf4et613 60 13 a a DT cord-015493-vf4et613 60 14 portion portion NN cord-015493-vf4et613 60 15 of of IN cord-015493-vf4et613 60 16 a a DT cord-015493-vf4et613 60 17 cryptic cryptic JJ cord-015493-vf4et613 60 18 plasmid plasmid NN cord-015493-vf4et613 60 19 in in IN cord-015493-vf4et613 60 20 C. C. NNP cord-015493-vf4et613 60 21 trachomatis trachomatis NN cord-015493-vf4et613 60 22 that that WDT cord-015493-vf4et613 60 23 has have VBZ cord-015493-vf4et613 60 24 been be VBN cord-015493-vf4et613 60 25 lost lose VBN cord-015493-vf4et613 60 26 by by IN cord-015493-vf4et613 60 27 some some DT cord-015493-vf4et613 60 28 isolates isolate NNS cord-015493-vf4et613 60 29 in in IN cord-015493-vf4et613 60 30 Sweden Sweden NNP cord-015493-vf4et613 60 31 , , , cord-015493-vf4et613 60 32 leading lead VBG cord-015493-vf4et613 60 33 to to IN cord-015493-vf4et613 60 34 false false JJ cord-015493-vf4et613 60 35 - - HYPH cord-015493-vf4et613 60 36 negative negative JJ cord-015493-vf4et613 60 37 results result NNS cord-015493-vf4et613 60 38 [ [ -LRB- cord-015493-vf4et613 60 39 1 1 CD cord-015493-vf4et613 60 40 ] ] -RRB- cord-015493-vf4et613 60 41 . . . cord-015493-vf4et613 61 1 Although although IN cord-015493-vf4et613 61 2 this this DT cord-015493-vf4et613 61 3 is be VBZ cord-015493-vf4et613 61 4 not not RB cord-015493-vf4et613 61 5 likely likely JJ cord-015493-vf4et613 61 6 to to TO cord-015493-vf4et613 61 7 have have VB cord-015493-vf4et613 61 8 affected affect VBN cord-015493-vf4et613 61 9 the the DT cord-015493-vf4et613 61 10 results result NNS cord-015493-vf4et613 61 11 of of IN cord-015493-vf4et613 61 12 this this DT cord-015493-vf4et613 61 13 study study NN cord-015493-vf4et613 61 14 , , , cord-015493-vf4et613 61 15 it -PRON- PRP cord-015493-vf4et613 61 16 is be VBZ cord-015493-vf4et613 61 17 an an DT cord-015493-vf4et613 61 18 issue issue NN cord-015493-vf4et613 61 19 that that WDT cord-015493-vf4et613 61 20 may may MD cord-015493-vf4et613 61 21 have have VB cord-015493-vf4et613 61 22 to to TO cord-015493-vf4et613 61 23 addressed address VBN cord-015493-vf4et613 61 24 in in IN cord-015493-vf4et613 61 25 the the DT cord-015493-vf4et613 61 26 future future NN cord-015493-vf4et613 61 27 . . . cord-015493-vf4et613 62 1 The the DT cord-015493-vf4et613 62 2 authors author NNS cord-015493-vf4et613 62 3 point point VBP cord-015493-vf4et613 62 4 out out RP cord-015493-vf4et613 62 5 that that IN cord-015493-vf4et613 62 6 these these DT cord-015493-vf4et613 62 7 data datum NNS cord-015493-vf4et613 62 8 support support VBP cord-015493-vf4et613 62 9 current current JJ cord-015493-vf4et613 62 10 recommendations recommendation NNS cord-015493-vf4et613 62 11 for for IN cord-015493-vf4et613 62 12 screening screen VBG cord-015493-vf4et613 62 13 sexually sexually RB cord-015493-vf4et613 62 14 active active JJ cord-015493-vf4et613 62 15 females female NNS cord-015493-vf4et613 63 1 aged aged JJ cord-015493-vf4et613 63 2 р25 р25 DT cord-015493-vf4et613 63 3 years year NNS cord-015493-vf4et613 63 4 for for IN cord-015493-vf4et613 63 5 chlamydial chlamydial JJ cord-015493-vf4et613 63 6 infection infection NN cord-015493-vf4et613 63 7 and and CC cord-015493-vf4et613 63 8 for for IN cord-015493-vf4et613 63 9 coadministration coadministration NN cord-015493-vf4et613 63 10 of of IN cord-015493-vf4et613 63 11 treatment treatment NN cord-015493-vf4et613 63 12 for for IN cord-015493-vf4et613 63 13 C. C. NNP cord-015493-vf4et613 63 14 trachomatis trachomatis NN cord-015493-vf4et613 63 15 infection infection NN cord-015493-vf4et613 63 16 in in IN cord-015493-vf4et613 63 17 patients patient NNS cord-015493-vf4et613 63 18 with with IN cord-015493-vf4et613 63 19 gonorrheal gonorrheal JJ cord-015493-vf4et613 63 20 infection infection NN cord-015493-vf4et613 63 21 , , , cord-015493-vf4et613 63 22 unless unless IN cord-015493-vf4et613 63 23 the the DT cord-015493-vf4et613 63 24 former former JJ cord-015493-vf4et613 63 25 has have VBZ cord-015493-vf4et613 63 26 been be VBN cord-015493-vf4et613 63 27 ruled rule VBN cord-015493-vf4et613 63 28 out out RP cord-015493-vf4et613 63 29 [ [ -LRB- cord-015493-vf4et613 63 30 2 2 CD cord-015493-vf4et613 63 31 ] ] -RRB- cord-015493-vf4et613 63 32 . . . cord-015493-vf4et613 64 1 The the DT cord-015493-vf4et613 64 2 following follow VBG cord-015493-vf4et613 64 3 is be VBZ cord-015493-vf4et613 64 4 a a DT cord-015493-vf4et613 64 5 summary summary NN cord-015493-vf4et613 64 6 of of IN cord-015493-vf4et613 64 7 current current JJ cord-015493-vf4et613 64 8 recommendations recommendation NNS cord-015493-vf4et613 64 9 for for IN cord-015493-vf4et613 64 10 screening screen VBG cord-015493-vf4et613 64 11 [ [ -LRB- cord-015493-vf4et613 64 12 2 2 CD cord-015493-vf4et613 64 13 ] ] -RRB- cord-015493-vf4et613 64 14 : : : cord-015493-vf4et613 65 1 • • NNP cord-015493-vf4et613 65 2 Screen screen NN cord-015493-vf4et613 65 3 for for IN cord-015493-vf4et613 65 4 chlamydial chlamydial JJ cord-015493-vf4et613 65 5 infection infection NN cord-015493-vf4et613 65 6 in in IN cord-015493-vf4et613 65 7 all all DT cord-015493-vf4et613 65 8 sexually sexually RB cord-015493-vf4et613 65 9 active active JJ cord-015493-vf4et613 65 10 , , , cord-015493-vf4et613 65 11 nonpregnant nonpregnant JJ cord-015493-vf4et613 65 12 , , , cord-015493-vf4et613 65 13 young young JJ cord-015493-vf4et613 65 14 women woman NNS cord-015493-vf4et613 65 15 ( ( -LRB- cord-015493-vf4et613 65 16 age age NN cord-015493-vf4et613 65 17 , , , cord-015493-vf4et613 65 18 р24 р24 CD cord-015493-vf4et613 65 19 years year NNS cord-015493-vf4et613 65 20 ) ) -RRB- cord-015493-vf4et613 65 21 and and CC cord-015493-vf4et613 65 22 in in IN cord-015493-vf4et613 65 23 older old JJR cord-015493-vf4et613 65 24 , , , cord-015493-vf4et613 65 25 nonpregnant nonpregnant JJ cord-015493-vf4et613 65 26 women woman NNS cord-015493-vf4et613 65 27 who who WP cord-015493-vf4et613 65 28 are be VBP cord-015493-vf4et613 65 29 at at IN cord-015493-vf4et613 65 30 increased increase VBN cord-015493-vf4et613 65 31 risk.• risk.• NNP cord-015493-vf4et613 65 32 Screen Screen NNP cord-015493-vf4et613 65 33 for for IN cord-015493-vf4et613 65 34 chlamydial chlamydial JJ cord-015493-vf4et613 65 35 infection infection NN cord-015493-vf4et613 65 36 in in IN cord-015493-vf4et613 65 37 all all DT cord-015493-vf4et613 65 38 pregnant pregnant JJ cord-015493-vf4et613 65 39 women woman NNS cord-015493-vf4et613 65 40 aged age VBN cord-015493-vf4et613 65 41 р24 р24 NNP cord-015493-vf4et613 65 42 years year NNS cord-015493-vf4et613 65 43 and and CC cord-015493-vf4et613 65 44 in in IN cord-015493-vf4et613 65 45 older old JJR cord-015493-vf4et613 65 46 , , , cord-015493-vf4et613 65 47 pregnant pregnant JJ cord-015493-vf4et613 65 48 women woman NNS cord-015493-vf4et613 65 49 who who WP cord-015493-vf4et613 65 50 are be VBP cord-015493-vf4et613 65 51 at at IN cord-015493-vf4et613 65 52 increased increase VBN cord-015493-vf4et613 65 53 risk.• risk.• NNP cord-015493-vf4et613 65 54 Do do VB cord-015493-vf4et613 65 55 not not RB cord-015493-vf4et613 65 56 routinely routinely RB cord-015493-vf4et613 65 57 screen screen VB cord-015493-vf4et613 65 58 for for IN cord-015493-vf4et613 65 59 chlamydial chlamydial JJ cord-015493-vf4et613 65 60 infection infection NN cord-015493-vf4et613 65 61 in in IN cord-015493-vf4et613 65 62 women woman NNS cord-015493-vf4et613 66 1 aged aged JJ cord-015493-vf4et613 66 2 у25 у25 CD cord-015493-vf4et613 66 3 years year NNS cord-015493-vf4et613 66 4 , , , cord-015493-vf4et613 66 5 regardless regardless RB cord-015493-vf4et613 66 6 of of IN cord-015493-vf4et613 66 7 whether whether IN cord-015493-vf4et613 66 8 they -PRON- PRP cord-015493-vf4et613 66 9 are be VBP cord-015493-vf4et613 66 10 pregnant pregnant JJ cord-015493-vf4et613 66 11 , , , cord-015493-vf4et613 66 12 if if IN cord-015493-vf4et613 66 13 they -PRON- PRP cord-015493-vf4et613 66 14 are be VBP cord-015493-vf4et613 66 15 not not RB cord-015493-vf4et613 66 16 at at IN cord-015493-vf4et613 66 17 increased increase VBN cord-015493-vf4et613 66 18 risk.• risk.• NNP cord-015493-vf4et613 66 19 Current current JJ cord-015493-vf4et613 66 20 evidence evidence NN cord-015493-vf4et613 66 21 is be VBZ cord-015493-vf4et613 66 22 insufficient insufficient JJ cord-015493-vf4et613 66 23 to to TO cord-015493-vf4et613 66 24 assess assess VB cord-015493-vf4et613 66 25 the the DT cord-015493-vf4et613 66 26 balance balance NN cord-015493-vf4et613 66 27 of of IN cord-015493-vf4et613 66 28 benefits benefit NNS cord-015493-vf4et613 66 29 and and CC cord-015493-vf4et613 66 30 harms harm NNS cord-015493-vf4et613 66 31 of of IN cord-015493-vf4et613 66 32 screening screening NN cord-015493-vf4et613 66 33 for for IN cord-015493-vf4et613 66 34 chlamydial chlamydial JJ cord-015493-vf4et613 66 35 infection infection NN cord-015493-vf4et613 66 36 in in IN cord-015493-vf4et613 66 37 men man NNS cord-015493-vf4et613 66 38 . . .