id sid tid token lemma pos cord-266696-w9sb038q 1 1 key key JJ cord-266696-w9sb038q 1 2 : : : cord-266696-w9sb038q 1 3 cord-266696-w9sb038q cord-266696-w9sb038q NN cord-266696-w9sb038q 1 4 authors author NNS cord-266696-w9sb038q 1 5 : : : cord-266696-w9sb038q 1 6 Zhou Zhou NNP cord-266696-w9sb038q 1 7 , , , cord-266696-w9sb038q 1 8 Yi Yi NNP cord-266696-w9sb038q 1 9 - - HYPH cord-266696-w9sb038q 1 10 Hua Hua NNP cord-266696-w9sb038q 1 11 ; ; : cord-266696-w9sb038q 1 12 Chen Chen NNP cord-266696-w9sb038q 1 13 , , , cord-266696-w9sb038q 2 1 Zhaochun Zhaochun NNP cord-266696-w9sb038q 2 2 title title NN cord-266696-w9sb038q 2 3 : : : cord-266696-w9sb038q 2 4 Is be VBZ cord-266696-w9sb038q 2 5 the the DT cord-266696-w9sb038q 2 6 Immune Immune NNP cord-266696-w9sb038q 2 7 System System NNP cord-266696-w9sb038q 3 1 Impaired impair VBN cord-266696-w9sb038q 3 2 in in IN cord-266696-w9sb038q 3 3 Patients patient NNS cord-266696-w9sb038q 3 4 with with IN cord-266696-w9sb038q 3 5 Severe severe JJ cord-266696-w9sb038q 3 6 Acute acute JJ cord-266696-w9sb038q 3 7 Respiratory respiratory JJ cord-266696-w9sb038q 3 8 Syndrome syndrome NN cord-266696-w9sb038q 3 9 ? ? . cord-266696-w9sb038q 4 1 date date NN cord-266696-w9sb038q 4 2 : : : cord-266696-w9sb038q 4 3 2004 2004 CD cord-266696-w9sb038q 4 4 - - HYPH cord-266696-w9sb038q 4 5 03 03 CD cord-266696-w9sb038q 4 6 - - SYM cord-266696-w9sb038q 4 7 15 15 CD cord-266696-w9sb038q 4 8 journal journal NN cord-266696-w9sb038q 4 9 : : : cord-266696-w9sb038q 5 1 Clin Clin NNP cord-266696-w9sb038q 5 2 Infect infect VB cord-266696-w9sb038q 5 3 Dis Dis NNP cord-266696-w9sb038q 5 4 DOI doi NN cord-266696-w9sb038q 5 5 : : : cord-266696-w9sb038q 6 1 10.1086/382081 10.1086/382081 CD cord-266696-w9sb038q 6 2 sha sha NNP cord-266696-w9sb038q 6 3 : : : cord-266696-w9sb038q 7 1 a5fe2af5585837597fc2e2be7b101b23214824c8 a5fe2af5585837597fc2e2be7b101b23214824c8 NNP cord-266696-w9sb038q 8 1 doc_id doc_id CD cord-266696-w9sb038q 9 1 : : : cord-266696-w9sb038q 9 2 266696 266696 CD cord-266696-w9sb038q 9 3 cord_uid cord_uid NNS cord-266696-w9sb038q 9 4 : : : cord-266696-w9sb038q 10 1 w9sb038q w9sb038q NNP cord-266696-w9sb038q 10 2 nan nan NNP cord-266696-w9sb038q 10 3 Severe Severe NNP cord-266696-w9sb038q 10 4 Acute acute JJ cord-266696-w9sb038q 10 5 Respiratory Respiratory NNP cord-266696-w9sb038q 10 6 Syndrome syndrome NN cord-266696-w9sb038q 10 7 ? ? . cord-266696-w9sb038q 11 1 Sir Sir NNP cord-266696-w9sb038q 11 2 - - HYPH cord-266696-w9sb038q 11 3 Cui Cui NNP cord-266696-w9sb038q 11 4 et et FW cord-266696-w9sb038q 11 5 al al NNP cord-266696-w9sb038q 11 6 . . . cord-266696-w9sb038q 12 1 [ [ -LRB- cord-266696-w9sb038q 12 2 1 1 LS cord-266696-w9sb038q 12 3 ] ] -RRB- cord-266696-w9sb038q 12 4 recently recently RB cord-266696-w9sb038q 12 5 described describe VBD cord-266696-w9sb038q 12 6 pronounced pronounce VBN cord-266696-w9sb038q 12 7 lymphopenia lymphopenia NNP cord-266696-w9sb038q 12 8 and and CC cord-266696-w9sb038q 12 9 low low JJ cord-266696-w9sb038q 12 10 counts count NNS cord-266696-w9sb038q 12 11 of of IN cord-266696-w9sb038q 12 12 CD4 CD4 NNP cord-266696-w9sb038q 12 13 + + CC cord-266696-w9sb038q 12 14 cells cell NNS cord-266696-w9sb038q 12 15 , , , cord-266696-w9sb038q 13 1 CD8 CD8 NNP cord-266696-w9sb038q 13 2 + + CC cord-266696-w9sb038q 13 3 cells cell NNS cord-266696-w9sb038q 13 4 , , , cord-266696-w9sb038q 13 5 and and CC cord-266696-w9sb038q 13 6 B b NN cord-266696-w9sb038q 13 7 cells cell NNS cord-266696-w9sb038q 13 8 in in IN cord-266696-w9sb038q 13 9 patients patient NNS cord-266696-w9sb038q 13 10 with with IN cord-266696-w9sb038q 13 11 severe severe JJ cord-266696-w9sb038q 13 12 acute acute JJ cord-266696-w9sb038q 13 13 respiratory respiratory JJ cord-266696-w9sb038q 13 14 syndrome syndrome NN cord-266696-w9sb038q 13 15 ( ( -LRB- cord-266696-w9sb038q 13 16 SARS SARS NNP cord-266696-w9sb038q 13 17 ) ) -RRB- cord-266696-w9sb038q 13 18 . . . cord-266696-w9sb038q 14 1 On on IN cord-266696-w9sb038q 14 2 the the DT cord-266696-w9sb038q 14 3 basis basis NN cord-266696-w9sb038q 14 4 of of IN cord-266696-w9sb038q 14 5 these these DT cord-266696-w9sb038q 14 6 low low JJ cord-266696-w9sb038q 14 7 cell cell NN cord-266696-w9sb038q 14 8 counts count NNS cord-266696-w9sb038q 14 9 , , , cord-266696-w9sb038q 14 10 Cui Cui NNP cord-266696-w9sb038q 14 11 et et FW cord-266696-w9sb038q 14 12 al al NNP cord-266696-w9sb038q 14 13 . . . cord-266696-w9sb038q 15 1 [ [ -LRB- cord-266696-w9sb038q 15 2 1 1 CD cord-266696-w9sb038q 15 3 ] ] -RRB- cord-266696-w9sb038q 15 4 suggested suggest VBD cord-266696-w9sb038q 15 5 that that IN cord-266696-w9sb038q 15 6 SARS SARS NNP cord-266696-w9sb038q 15 7 coronavirus coronavirus NN cord-266696-w9sb038q 15 8 ( ( -LRB- cord-266696-w9sb038q 15 9 SARS SARS NNP cord-266696-w9sb038q 15 10 - - HYPH cord-266696-w9sb038q 15 11 CoV CoV NNP cord-266696-w9sb038q 15 12 ) ) -RRB- cord-266696-w9sb038q 15 13 might may MD cord-266696-w9sb038q 15 14 damage damage VB cord-266696-w9sb038q 15 15 lymphocytes lymphocyte NNS cord-266696-w9sb038q 15 16 and and CC cord-266696-w9sb038q 15 17 concluded conclude VBD cord-266696-w9sb038q 15 18 that that IN cord-266696-w9sb038q 15 19 the the DT cord-266696-w9sb038q 15 20 immune immune JJ cord-266696-w9sb038q 15 21 system system NN cord-266696-w9sb038q 15 22 was be VBD cord-266696-w9sb038q 15 23 impaired impair VBN cord-266696-w9sb038q 15 24 during during IN cord-266696-w9sb038q 15 25 the the DT cord-266696-w9sb038q 15 26 course course NN cord-266696-w9sb038q 15 27 of of IN cord-266696-w9sb038q 15 28 SARS SARS NNP cord-266696-w9sb038q 15 29 . . . cord-266696-w9sb038q 16 1 However however RB cord-266696-w9sb038q 16 2 , , , cord-266696-w9sb038q 16 3 Cui Cui NNP cord-266696-w9sb038q 16 4 et et FW cord-266696-w9sb038q 16 5 al al NNP cord-266696-w9sb038q 16 6 . . . cord-266696-w9sb038q 17 1 [ [ -LRB- cord-266696-w9sb038q 17 2 1 1 CD cord-266696-w9sb038q 17 3 ] ] -RRB- cord-266696-w9sb038q 17 4 did do VBD cord-266696-w9sb038q 17 5 not not RB cord-266696-w9sb038q 17 6 provide provide VB cord-266696-w9sb038q 17 7 direct direct JJ cord-266696-w9sb038q 17 8 evidence evidence NN cord-266696-w9sb038q 17 9 to to TO cord-266696-w9sb038q 17 10 support support VB cord-266696-w9sb038q 17 11 their -PRON- PRP$ cord-266696-w9sb038q 17 12 hypothesis hypothesis NN cord-266696-w9sb038q 17 13 . . . cord-266696-w9sb038q 18 1 Low low JJ cord-266696-w9sb038q 18 2 counts count NNS cord-266696-w9sb038q 18 3 of of IN cord-266696-w9sb038q 18 4 both both DT cord-266696-w9sb038q 18 5 CD4 CD4 NNP cord-266696-w9sb038q 18 6 + + CC cord-266696-w9sb038q 18 7 and and CC cord-266696-w9sb038q 18 8 CD8 CD8 NNP cord-266696-w9sb038q 18 9 + + CC cord-266696-w9sb038q 18 10 cells cell NNS cord-266696-w9sb038q 18 11 in in IN cord-266696-w9sb038q 18 12 the the DT cord-266696-w9sb038q 18 13 peripheral peripheral JJ cord-266696-w9sb038q 18 14 circulation circulation NN cord-266696-w9sb038q 18 15 do do VBP cord-266696-w9sb038q 18 16 not not RB cord-266696-w9sb038q 18 17 always always RB cord-266696-w9sb038q 18 18 indicate indicate VB cord-266696-w9sb038q 18 19 that that IN cord-266696-w9sb038q 18 20 the the DT cord-266696-w9sb038q 18 21 immune immune JJ cord-266696-w9sb038q 18 22 system system NN cord-266696-w9sb038q 18 23 is be VBZ cord-266696-w9sb038q 18 24 impaired impair VBN cord-266696-w9sb038q 18 25 : : : cord-266696-w9sb038q 18 26 redistribution redistribution NN cord-266696-w9sb038q 18 27 of of IN cord-266696-w9sb038q 18 28 lymphocytes lymphocyte NNS cord-266696-w9sb038q 18 29 among among IN cord-266696-w9sb038q 18 30 peripheral peripheral JJ cord-266696-w9sb038q 18 31 and and CC cord-266696-w9sb038q 18 32 secondary secondary JJ cord-266696-w9sb038q 18 33 lymphoid lymphoid JJ cord-266696-w9sb038q 18 34 organs organ NNS cord-266696-w9sb038q 18 35 and and CC cord-266696-w9sb038q 18 36 migration migration NN cord-266696-w9sb038q 18 37 of of IN cord-266696-w9sb038q 18 38 these these DT cord-266696-w9sb038q 18 39 cells cell NNS cord-266696-w9sb038q 18 40 to to IN cord-266696-w9sb038q 18 41 inflamed inflamed JJ cord-266696-w9sb038q 18 42 tissues tissue NNS cord-266696-w9sb038q 18 43 caused cause VBN cord-266696-w9sb038q 18 44 by by IN cord-266696-w9sb038q 18 45 infections infection NNS cord-266696-w9sb038q 18 46 may may MD cord-266696-w9sb038q 18 47 also also RB cord-266696-w9sb038q 18 48 result result VB cord-266696-w9sb038q 18 49 in in IN cord-266696-w9sb038q 18 50 lymphopenia lymphopenia NNP cord-266696-w9sb038q 18 51 . . . cord-266696-w9sb038q 19 1 Postthymus Postthymus NNP cord-266696-w9sb038q 19 2 naive naive JJ cord-266696-w9sb038q 19 3 T t NN cord-266696-w9sb038q 19 4 cells cell NNS cord-266696-w9sb038q 19 5 do do VBP cord-266696-w9sb038q 19 6 not not RB cord-266696-w9sb038q 19 7 reside reside VB cord-266696-w9sb038q 19 8 in in IN cord-266696-w9sb038q 19 9 any any DT cord-266696-w9sb038q 19 10 single single JJ cord-266696-w9sb038q 19 11 lymphoid lymphoid JJ cord-266696-w9sb038q 19 12 organ organ NN cord-266696-w9sb038q 19 13 but but CC cord-266696-w9sb038q 19 14 , , , cord-266696-w9sb038q 19 15 rather rather RB cord-266696-w9sb038q 19 16 , , , cord-266696-w9sb038q 19 17 circulate circulate VBP cord-266696-w9sb038q 19 18 continuously continuously RB cord-266696-w9sb038q 19 19 between between IN cord-266696-w9sb038q 19 20 blood blood NN cord-266696-w9sb038q 19 21 and and CC cord-266696-w9sb038q 19 22 lymph lymph NN cord-266696-w9sb038q 19 23 through through IN cord-266696-w9sb038q 19 24 a a DT cord-266696-w9sb038q 19 25 specialized specialized JJ cord-266696-w9sb038q 19 26 T t NN cord-266696-w9sb038q 19 27 cell cell NN cord-266696-w9sb038q 19 28 zone zone NN cord-266696-w9sb038q 19 29 in in IN cord-266696-w9sb038q 19 30 secondary secondary JJ cord-266696-w9sb038q 19 31 lymphoid lymphoid JJ cord-266696-w9sb038q 19 32 tissues tissue NNS cord-266696-w9sb038q 19 33 , , , cord-266696-w9sb038q 19 34 which which WDT cord-266696-w9sb038q 19 35 forms form VBZ cord-266696-w9sb038q 19 36 part part NN cord-266696-w9sb038q 19 37 of of IN cord-266696-w9sb038q 19 38 the the DT cord-266696-w9sb038q 19 39 " " `` cord-266696-w9sb038q 19 40 recirculating recirculate VBG cord-266696-w9sb038q 19 41 lymphocyte lymphocyte NN cord-266696-w9sb038q 19 42 pool pool NN cord-266696-w9sb038q 19 43 . . . cord-266696-w9sb038q 19 44 " " '' cord-266696-w9sb038q 20 1 Neither neither CC cord-266696-w9sb038q 20 2 splenectomy splenectomy NN cord-266696-w9sb038q 20 3 nor nor CC cord-266696-w9sb038q 20 4 ablation ablation NN cord-266696-w9sb038q 20 5 of of IN cord-266696-w9sb038q 20 6 bone bone NN cord-266696-w9sb038q 20 7 marrow marrow NN cord-266696-w9sb038q 20 8 by by IN cord-266696-w9sb038q 20 9 radioactive radioactive JJ cord-266696-w9sb038q 20 10 isotope isotope NN cord-266696-w9sb038q 20 11 therapy therapy NN cord-266696-w9sb038q 20 12 reduces reduce VBZ cord-266696-w9sb038q 20 13 the the DT cord-266696-w9sb038q 20 14 number number NN cord-266696-w9sb038q 20 15 of of IN cord-266696-w9sb038q 20 16 lymphocytes lymphocyte NNS cord-266696-w9sb038q 20 17 , , , cord-266696-w9sb038q 20 18 and and CC cord-266696-w9sb038q 20 19 thymectomy thymectomy VBD cord-266696-w9sb038q 20 20 in in IN cord-266696-w9sb038q 20 21 adult adult NN cord-266696-w9sb038q 20 22 mice mouse NNS cord-266696-w9sb038q 20 23 causes cause VBZ cord-266696-w9sb038q 20 24 only only RB cord-266696-w9sb038q 20 25 a a DT cord-266696-w9sb038q 20 26 very very RB cord-266696-w9sb038q 20 27 slow slow JJ cord-266696-w9sb038q 20 28 decrease decrease NN cord-266696-w9sb038q 20 29 in in IN cord-266696-w9sb038q 20 30 the the DT cord-266696-w9sb038q 20 31 size size NN cord-266696-w9sb038q 20 32 of of IN cord-266696-w9sb038q 20 33 the the DT cord-266696-w9sb038q 20 34 recirculating recirculate VBG cord-266696-w9sb038q 20 35 lymphocyte lymphocyte NN cord-266696-w9sb038q 20 36 pool pool NN cord-266696-w9sb038q 20 37 . . . cord-266696-w9sb038q 21 1 These these DT cord-266696-w9sb038q 21 2 findings finding NNS cord-266696-w9sb038q 21 3 suggest suggest VBP cord-266696-w9sb038q 21 4 that that IN cord-266696-w9sb038q 21 5 splenic splenic JJ cord-266696-w9sb038q 21 6 atrophy atrophy NN cord-266696-w9sb038q 21 7 and and CC cord-266696-w9sb038q 21 8 pathological pathological JJ cord-266696-w9sb038q 21 9 changes change NNS cord-266696-w9sb038q 21 10 in in IN cord-266696-w9sb038q 21 11 lymph lymph NN cord-266696-w9sb038q 21 12 nodes node NNS cord-266696-w9sb038q 21 13 observed observe VBN cord-266696-w9sb038q 21 14 in in IN cord-266696-w9sb038q 21 15 patients patient NNS cord-266696-w9sb038q 21 16 with with IN cord-266696-w9sb038q 21 17 SARS SARS NNP cord-266696-w9sb038q 21 18 [ [ -LRB- cord-266696-w9sb038q 21 19 2 2 CD cord-266696-w9sb038q 21 20 ] ] -RRB- cord-266696-w9sb038q 21 21 [ [ -LRB- cord-266696-w9sb038q 21 22 3 3 CD cord-266696-w9sb038q 21 23 ] ] -RRB- cord-266696-w9sb038q 21 24 [ [ -LRB- cord-266696-w9sb038q 21 25 4 4 CD cord-266696-w9sb038q 21 26 ] ] -RRB- cord-266696-w9sb038q 21 27 were be VBD cord-266696-w9sb038q 21 28 not not RB cord-266696-w9sb038q 21 29 the the DT cord-266696-w9sb038q 21 30 causes cause NNS cord-266696-w9sb038q 21 31 of of IN cord-266696-w9sb038q 21 32 lymphopenia lymphopenia NNP cord-266696-w9sb038q 21 33 . . . cord-266696-w9sb038q 22 1 Although although IN cord-266696-w9sb038q 22 2 SARS SARS NNP cord-266696-w9sb038q 22 3 - - HYPH cord-266696-w9sb038q 22 4 CoV CoV NNP cord-266696-w9sb038q 22 5 RNA RNA NNP cord-266696-w9sb038q 22 6 was be VBD cord-266696-w9sb038q 22 7 detected detect VBN cord-266696-w9sb038q 22 8 in in IN cord-266696-w9sb038q 22 9 PBMCs pbmc NNS cord-266696-w9sb038q 22 10 obtained obtain VBN cord-266696-w9sb038q 22 11 from from IN cord-266696-w9sb038q 22 12 patients patient NNS cord-266696-w9sb038q 22 13 with with IN cord-266696-w9sb038q 22 14 SARS SARS NNP cord-266696-w9sb038q 22 15 [ [ -LRB- cord-266696-w9sb038q 22 16 5 5 CD cord-266696-w9sb038q 22 17 ] ] -RRB- cord-266696-w9sb038q 22 18 , , , cord-266696-w9sb038q 22 19 no no DT cord-266696-w9sb038q 22 20 SARS SARS NNP cord-266696-w9sb038q 22 21 - - HYPH cord-266696-w9sb038q 22 22 CoV CoV NNP cord-266696-w9sb038q 22 23 was be VBD cord-266696-w9sb038q 22 24 recovered recover VBN cord-266696-w9sb038q 22 25 from from IN cord-266696-w9sb038q 22 26 splenic splenic JJ cord-266696-w9sb038q 22 27 , , , cord-266696-w9sb038q 22 28 lymphatic lymphatic NN cord-266696-w9sb038q 22 29 , , , cord-266696-w9sb038q 22 30 and and CC cord-266696-w9sb038q 22 31 bone bone NN cord-266696-w9sb038q 22 32 marrow marrow NN cord-266696-w9sb038q 22 33 specimens specimen NNS cord-266696-w9sb038q 22 34 obtained obtain VBN cord-266696-w9sb038q 22 35 from from IN cord-266696-w9sb038q 22 36 patients patient NNS cord-266696-w9sb038q 22 37 with with IN cord-266696-w9sb038q 22 38 fatal fatal JJ cord-266696-w9sb038q 22 39 cases case NNS cord-266696-w9sb038q 22 40 [ [ -LRB- cord-266696-w9sb038q 22 41 3 3 CD cord-266696-w9sb038q 22 42 ] ] -RRB- cord-266696-w9sb038q 22 43 . . . cord-266696-w9sb038q 23 1 This this DT cord-266696-w9sb038q 23 2 finding finding NN cord-266696-w9sb038q 23 3 indicated indicate VBD cord-266696-w9sb038q 23 4 that that IN cord-266696-w9sb038q 23 5 the the DT cord-266696-w9sb038q 23 6 pathological pathological JJ cord-266696-w9sb038q 23 7 presentations presentation NNS cord-266696-w9sb038q 23 8 in in IN cord-266696-w9sb038q 23 9 lymphoid lymphoid JJ cord-266696-w9sb038q 23 10 organs organ NNS cord-266696-w9sb038q 23 11 were be VBD cord-266696-w9sb038q 23 12 unlikely unlikely JJ cord-266696-w9sb038q 23 13 to to TO cord-266696-w9sb038q 23 14 have have VB cord-266696-w9sb038q 23 15 been be VBN cord-266696-w9sb038q 23 16 directly directly RB cord-266696-w9sb038q 23 17 caused cause VBN cord-266696-w9sb038q 23 18 by by IN cord-266696-w9sb038q 23 19 the the DT cord-266696-w9sb038q 23 20 virus virus NN cord-266696-w9sb038q 23 21 . . . cord-266696-w9sb038q 24 1 If if IN cord-266696-w9sb038q 24 2 SARS SARS NNP cord-266696-w9sb038q 24 3 - - HYPH cord-266696-w9sb038q 24 4 CoV CoV NNP cord-266696-w9sb038q 24 5 was be VBD cord-266696-w9sb038q 24 6 directly directly RB cord-266696-w9sb038q 24 7 detrimental detrimental JJ cord-266696-w9sb038q 24 8 to to IN cord-266696-w9sb038q 24 9 lymphocytes lymphocyte NNS cord-266696-w9sb038q 24 10 , , , cord-266696-w9sb038q 24 11 the the DT cord-266696-w9sb038q 24 12 damage damage NN cord-266696-w9sb038q 24 13 should should MD cord-266696-w9sb038q 24 14 start start VB cord-266696-w9sb038q 24 15 at at IN cord-266696-w9sb038q 24 16 the the DT cord-266696-w9sb038q 24 17 beginning beginning NN cord-266696-w9sb038q 24 18 of of IN cord-266696-w9sb038q 24 19 infection infection NN cord-266696-w9sb038q 24 20 and and CC cord-266696-w9sb038q 24 21 continue continue VB cord-266696-w9sb038q 24 22 through through IN cord-266696-w9sb038q 24 23 the the DT cord-266696-w9sb038q 24 24 incubation incubation NN cord-266696-w9sb038q 24 25 period period NN cord-266696-w9sb038q 24 26 , , , cord-266696-w9sb038q 24 27 resulting result VBG cord-266696-w9sb038q 24 28 in in IN cord-266696-w9sb038q 24 29 a a DT cord-266696-w9sb038q 24 30 decreased decreased JJ cord-266696-w9sb038q 24 31 lymphocyte lymphocyte NN cord-266696-w9sb038q 24 32 count count NN cord-266696-w9sb038q 24 33 after after IN cord-266696-w9sb038q 24 34 the the DT cord-266696-w9sb038q 24 35 onset onset NN cord-266696-w9sb038q 24 36 of of IN cord-266696-w9sb038q 24 37 SARS SARS NNP cord-266696-w9sb038q 24 38 . . . cord-266696-w9sb038q 25 1 However however RB cord-266696-w9sb038q 25 2 , , , cord-266696-w9sb038q 25 3 although although IN cord-266696-w9sb038q 25 4 most most JJS cord-266696-w9sb038q 25 5 patients patient NNS cord-266696-w9sb038q 25 6 had have VBD cord-266696-w9sb038q 25 7 mild mild JJ cord-266696-w9sb038q 25 8 to to TO cord-266696-w9sb038q 25 9 moderate moderate JJ cord-266696-w9sb038q 25 10 decreased decreased JJ cord-266696-w9sb038q 25 11 lymphocyte lymphocyte NN cord-266696-w9sb038q 25 12 counts count NNS cord-266696-w9sb038q 25 13 during during IN cord-266696-w9sb038q 25 14 the the DT cord-266696-w9sb038q 25 15 early early JJ cord-266696-w9sb038q 25 16 phase phase NN cord-266696-w9sb038q 25 17 of of IN cord-266696-w9sb038q 25 18 illness illness NN cord-266696-w9sb038q 25 19 [ [ -LRB- cord-266696-w9sb038q 25 20 6 6 CD cord-266696-w9sb038q 25 21 , , , cord-266696-w9sb038q 25 22 7 7 CD cord-266696-w9sb038q 25 23 ] ] -RRB- cord-266696-w9sb038q 25 24 , , , cord-266696-w9sb038q 25 25 many many JJ cord-266696-w9sb038q 25 26 patients patient NNS cord-266696-w9sb038q 25 27 had have VBD cord-266696-w9sb038q 25 28 normal normal JJ cord-266696-w9sb038q 25 29 lymphocyte lymphocyte NN cord-266696-w9sb038q 25 30 counts count NNS cord-266696-w9sb038q 25 31 at at IN cord-266696-w9sb038q 25 32 the the DT cord-266696-w9sb038q 25 33 onset onset NN cord-266696-w9sb038q 25 34 of of IN cord-266696-w9sb038q 25 35 symptoms symptom NNS cord-266696-w9sb038q 25 36 , , , cord-266696-w9sb038q 25 37 and and CC cord-266696-w9sb038q 25 38 some some DT cord-266696-w9sb038q 25 39 even even RB cord-266696-w9sb038q 25 40 had have VBD cord-266696-w9sb038q 25 41 increased increase VBN cord-266696-w9sb038q 25 42 CD4 CD4 NNP cord-266696-w9sb038q 25 43 + + CC cord-266696-w9sb038q 25 44 and and CC cord-266696-w9sb038q 25 45 CD8 CD8 NNP cord-266696-w9sb038q 25 46 + + CC cord-266696-w9sb038q 25 47 cell cell NN cord-266696-w9sb038q 25 48 counts count NNS cord-266696-w9sb038q 25 49 during during IN cord-266696-w9sb038q 25 50 the the DT cord-266696-w9sb038q 25 51 first first JJ cord-266696-w9sb038q 25 52 week week NN cord-266696-w9sb038q 25 53 of of IN cord-266696-w9sb038q 25 54 illness illness NN cord-266696-w9sb038q 25 55 [ [ -LRB- cord-266696-w9sb038q 25 56 3 3 CD cord-266696-w9sb038q 25 57 ] ] -RRB- cord-266696-w9sb038q 25 58 . . . cord-266696-w9sb038q 26 1 Clinically clinically RB cord-266696-w9sb038q 26 2 , , , cord-266696-w9sb038q 26 3 there there EX cord-266696-w9sb038q 26 4 is be VBZ cord-266696-w9sb038q 26 5 no no DT cord-266696-w9sb038q 26 6 evidence evidence NN cord-266696-w9sb038q 26 7 that that IN cord-266696-w9sb038q 26 8 the the DT cord-266696-w9sb038q 26 9 onset onset NN cord-266696-w9sb038q 26 10 of of IN cord-266696-w9sb038q 26 11 SARS SARS NNP cord-266696-w9sb038q 26 12 is be VBZ cord-266696-w9sb038q 26 13 associated associate VBN cord-266696-w9sb038q 26 14 with with IN cord-266696-w9sb038q 26 15 impairment impairment NN cord-266696-w9sb038q 26 16 of of IN cord-266696-w9sb038q 26 17 the the DT cord-266696-w9sb038q 26 18 immune immune JJ cord-266696-w9sb038q 26 19 system system NN cord-266696-w9sb038q 26 20 . . . cord-266696-w9sb038q 27 1 SARS SARS NNP cord-266696-w9sb038q 27 2 is be VBZ cord-266696-w9sb038q 27 3 characterized characterize VBN cord-266696-w9sb038q 27 4 by by IN cord-266696-w9sb038q 27 5 respiratory respiratory JJ cord-266696-w9sb038q 27 6 symptoms symptom NNS cord-266696-w9sb038q 27 7 and and CC cord-266696-w9sb038q 27 8 signs sign NNS cord-266696-w9sb038q 27 9 correlated correlate VBN cord-266696-w9sb038q 27 10 with with IN cord-266696-w9sb038q 27 11 pulmonary pulmonary JJ cord-266696-w9sb038q 27 12 lesions lesion NNS cord-266696-w9sb038q 27 13 caused cause VBN cord-266696-w9sb038q 27 14 by by IN cord-266696-w9sb038q 27 15 SARS SARS NNP cord-266696-w9sb038q 27 16 - - HYPH cord-266696-w9sb038q 27 17 CoV CoV NNP cord-266696-w9sb038q 27 18 infection infection NN cord-266696-w9sb038q 27 19 . . . cord-266696-w9sb038q 28 1 At at IN cord-266696-w9sb038q 28 2 the the DT cord-266696-w9sb038q 28 3 time time NN cord-266696-w9sb038q 28 4 of of IN cord-266696-w9sb038q 28 5 writing writing NN cord-266696-w9sb038q 28 6 , , , cord-266696-w9sb038q 28 7 no no DT cord-266696-w9sb038q 28 8 report report NN cord-266696-w9sb038q 28 9 has have VBZ cord-266696-w9sb038q 28 10 shown show VBN cord-266696-w9sb038q 28 11 that that IN cord-266696-w9sb038q 28 12 the the DT cord-266696-w9sb038q 28 13 initial initial JJ cord-266696-w9sb038q 28 14 manifestation manifestation NN cord-266696-w9sb038q 28 15 of of IN cord-266696-w9sb038q 28 16 SARS SARS NNP cord-266696-w9sb038q 28 17 is be VBZ cord-266696-w9sb038q 28 18 caused cause VBN cord-266696-w9sb038q 28 19 by by IN cord-266696-w9sb038q 28 20 immunosuppression immunosuppression NN cord-266696-w9sb038q 28 21 ( ( -LRB- cord-266696-w9sb038q 28 22 e.g. e.g. RB cord-266696-w9sb038q 28 23 , , , cord-266696-w9sb038q 28 24 AIDS AIDS NNP cord-266696-w9sb038q 28 25 ) ) -RRB- cord-266696-w9sb038q 28 26 , , , cord-266696-w9sb038q 28 27 and and CC cord-266696-w9sb038q 28 28 only only RB cord-266696-w9sb038q 28 29 a a DT cord-266696-w9sb038q 28 30 small small JJ cord-266696-w9sb038q 28 31 portion portion NN cord-266696-w9sb038q 28 32 of of IN cord-266696-w9sb038q 28 33 the the DT cord-266696-w9sb038q 28 34 patients patient NNS cord-266696-w9sb038q 28 35 have have VBP cord-266696-w9sb038q 28 36 had have VBN cord-266696-w9sb038q 28 37 secondary secondary JJ cord-266696-w9sb038q 28 38 bacterial bacterial JJ cord-266696-w9sb038q 28 39 infections infection NNS cord-266696-w9sb038q 28 40 - - : cord-266696-w9sb038q 28 41 which which WDT cord-266696-w9sb038q 28 42 were be VBD cord-266696-w9sb038q 28 43 easily easily RB cord-266696-w9sb038q 28 44 treatable treatable JJ cord-266696-w9sb038q 28 45 - - : cord-266696-w9sb038q 28 46 during during IN cord-266696-w9sb038q 28 47 the the DT cord-266696-w9sb038q 28 48 late late JJ cord-266696-w9sb038q 28 49 course course NN cord-266696-w9sb038q 28 50 of of IN cord-266696-w9sb038q 28 51 illness illness NN cord-266696-w9sb038q 28 52 , , , cord-266696-w9sb038q 28 53 despite despite IN cord-266696-w9sb038q 28 54 receipt receipt NN cord-266696-w9sb038q 28 55 of of IN cord-266696-w9sb038q 28 56 corticosteroid corticosteroid NN cord-266696-w9sb038q 28 57 treatment treatment NN cord-266696-w9sb038q 28 58 [ [ -LRB- cord-266696-w9sb038q 28 59 8 8 CD cord-266696-w9sb038q 28 60 ] ] -RRB- cord-266696-w9sb038q 28 61 . . . cord-266696-w9sb038q 29 1 The the DT cord-266696-w9sb038q 29 2 effectiveness effectiveness NN cord-266696-w9sb038q 29 3 of of IN cord-266696-w9sb038q 29 4 corticosteroid corticosteroid NN cord-266696-w9sb038q 29 5 therapy therapy NN cord-266696-w9sb038q 29 6 in in IN cord-266696-w9sb038q 29 7 stopping stop VBG cord-266696-w9sb038q 29 8 the the DT cord-266696-w9sb038q 29 9 progression progression NN cord-266696-w9sb038q 29 10 of of IN cord-266696-w9sb038q 29 11 pulmonary pulmonary JJ cord-266696-w9sb038q 29 12 lesions lesion NNS cord-266696-w9sb038q 29 13 in in IN cord-266696-w9sb038q 29 14 patients patient NNS cord-266696-w9sb038q 29 15 with with IN cord-266696-w9sb038q 29 16 SARS SARS NNP cord-266696-w9sb038q 29 17 also also RB cord-266696-w9sb038q 29 18 suggests suggest VBZ cord-266696-w9sb038q 29 19 that that IN cord-266696-w9sb038q 29 20 SARS SARS NNP cord-266696-w9sb038q 29 21 is be VBZ cord-266696-w9sb038q 29 22 not not RB cord-266696-w9sb038q 29 23 associated associate VBN cord-266696-w9sb038q 29 24 with with IN cord-266696-w9sb038q 29 25 the the DT cord-266696-w9sb038q 29 26 impairment impairment NN cord-266696-w9sb038q 29 27 of of IN cord-266696-w9sb038q 29 28 the the DT cord-266696-w9sb038q 29 29 immune immune JJ cord-266696-w9sb038q 29 30 system system NN cord-266696-w9sb038q 29 31 but but CC cord-266696-w9sb038q 29 32 is be VBZ cord-266696-w9sb038q 29 33 associated associate VBN cord-266696-w9sb038q 29 34 with with IN cord-266696-w9sb038q 29 35 immunopathological immunopathological JJ cord-266696-w9sb038q 29 36 damage damage NN cord-266696-w9sb038q 29 37 [ [ -LRB- cord-266696-w9sb038q 29 38 9 9 CD cord-266696-w9sb038q 29 39 ] ] -RRB- cord-266696-w9sb038q 29 40 . . . cord-266696-w9sb038q 30 1 Cui Cui NNP cord-266696-w9sb038q 30 2 et et FW cord-266696-w9sb038q 30 3 al al NNP cord-266696-w9sb038q 30 4 . . . cord-266696-w9sb038q 31 1 [ [ -LRB- cord-266696-w9sb038q 31 2 1 1 LS cord-266696-w9sb038q 31 3 ] ] -RRB- cord-266696-w9sb038q 31 4 also also RB cord-266696-w9sb038q 31 5 found find VBD cord-266696-w9sb038q 31 6 that that IN cord-266696-w9sb038q 31 7 76 76 CD cord-266696-w9sb038q 31 8 % % NN cord-266696-w9sb038q 31 9 of of IN cord-266696-w9sb038q 31 10 patients patient NNS cord-266696-w9sb038q 31 11 with with IN cord-266696-w9sb038q 31 12 SARS SARS NNP cord-266696-w9sb038q 31 13 had have VBD cord-266696-w9sb038q 31 14 a a DT cord-266696-w9sb038q 31 15 low low JJ cord-266696-w9sb038q 31 16 B b NN cord-266696-w9sb038q 31 17 cell cell NN cord-266696-w9sb038q 31 18 count count NN cord-266696-w9sb038q 31 19 . . . cord-266696-w9sb038q 32 1 However however RB cord-266696-w9sb038q 32 2 , , , cord-266696-w9sb038q 32 3 the the DT cord-266696-w9sb038q 32 4 immune immune JJ cord-266696-w9sb038q 32 5 function function NN cord-266696-w9sb038q 32 6 of of IN cord-266696-w9sb038q 32 7 B b NN cord-266696-w9sb038q 32 8 cells cell NNS cord-266696-w9sb038q 32 9 in in IN cord-266696-w9sb038q 32 10 patients patient NNS cord-266696-w9sb038q 32 11 with with IN cord-266696-w9sb038q 32 12 SARS SARS NNP cord-266696-w9sb038q 32 13 appeared appear VBD cord-266696-w9sb038q 32 14 not not RB cord-266696-w9sb038q 32 15 to to TO cord-266696-w9sb038q 32 16 have have VB cord-266696-w9sb038q 32 17 been be VBN cord-266696-w9sb038q 32 18 impaired impair VBN cord-266696-w9sb038q 32 19 , , , cord-266696-w9sb038q 32 20 because because IN cord-266696-w9sb038q 32 21 specific specific JJ cord-266696-w9sb038q 32 22 anti anti JJ cord-266696-w9sb038q 32 23 - - JJ cord-266696-w9sb038q 32 24 SARS SARS NNP cord-266696-w9sb038q 32 25 - - HYPH cord-266696-w9sb038q 32 26 CoV CoV NNP cord-266696-w9sb038q 32 27 was be VBD cord-266696-w9sb038q 32 28 detected detect VBN cord-266696-w9sb038q 32 29 as as RB cord-266696-w9sb038q 32 30 early early RB cord-266696-w9sb038q 32 31 as as IN cord-266696-w9sb038q 32 32 day day NN cord-266696-w9sb038q 32 33 10 10 CD cord-266696-w9sb038q 32 34 after after IN cord-266696-w9sb038q 32 35 the the DT cord-266696-w9sb038q 32 36 onset onset NN cord-266696-w9sb038q 32 37 of of IN cord-266696-w9sb038q 32 38 illness illness NN cord-266696-w9sb038q 32 39 [ [ -LRB- cord-266696-w9sb038q 32 40 8 8 CD cord-266696-w9sb038q 32 41 ] ] -RRB- cord-266696-w9sb038q 32 42 , , . cord-266696-w9sb038q 33 1 93%-100 93%-100 CD cord-266696-w9sb038q 33 2 % % NN cord-266696-w9sb038q 33 3 of of IN cord-266696-w9sb038q 33 4 the the DT cord-266696-w9sb038q 33 5 patients patient NNS cord-266696-w9sb038q 33 6 had have VBD cord-266696-w9sb038q 33 7 seroconversion seroconversion NN cord-266696-w9sb038q 33 8 to to IN cord-266696-w9sb038q 33 9 anti anti JJ cord-266696-w9sb038q 33 10 - - JJ cord-266696-w9sb038q 33 11 SARS SARS NNP cord-266696-w9sb038q 33 12 - - HYPH cord-266696-w9sb038q 33 13 CoV CoV NNP cord-266696-w9sb038q 33 14 after after IN cord-266696-w9sb038q 33 15 week week NN cord-266696-w9sb038q 33 16 3 3 CD cord-266696-w9sb038q 33 17 [ [ -LRB- cord-266696-w9sb038q 33 18 8 8 CD cord-266696-w9sb038q 33 19 , , , cord-266696-w9sb038q 33 20 10 10 CD cord-266696-w9sb038q 33 21 ] ] -RRB- cord-266696-w9sb038q 33 22 , , , cord-266696-w9sb038q 33 23 and and CC cord-266696-w9sb038q 33 24 the the DT cord-266696-w9sb038q 33 25 level level NN cord-266696-w9sb038q 33 26 of of IN cord-266696-w9sb038q 33 27 specific specific JJ cord-266696-w9sb038q 33 28 IgG igg NN cord-266696-w9sb038q 33 29 remained remain VBD cord-266696-w9sb038q 33 30 high high JJ cord-266696-w9sb038q 33 31 for for IN cord-266696-w9sb038q 33 32 at at RB cord-266696-w9sb038q 33 33 least least JJS cord-266696-w9sb038q 33 34 3 3 CD cord-266696-w9sb038q 33 35 months month NNS cord-266696-w9sb038q 33 36 [ [ -LRB- cord-266696-w9sb038q 33 37 10 10 CD cord-266696-w9sb038q 33 38 ] ] -RRB- cord-266696-w9sb038q 33 39 . . . cord-266696-w9sb038q 34 1 In in IN cord-266696-w9sb038q 34 2 conclusion conclusion NN cord-266696-w9sb038q 34 3 , , , cord-266696-w9sb038q 34 4 although although IN cord-266696-w9sb038q 34 5 lymphopenia lymphopenia NNP cord-266696-w9sb038q 34 6 does do VBZ cord-266696-w9sb038q 34 7 occur occur VB cord-266696-w9sb038q 34 8 in in IN cord-266696-w9sb038q 34 9 patients patient NNS cord-266696-w9sb038q 34 10 with with IN cord-266696-w9sb038q 34 11 SARS SARS NNP cord-266696-w9sb038q 34 12 , , , cord-266696-w9sb038q 34 13 no no DT cord-266696-w9sb038q 34 14 evidence evidence NN cord-266696-w9sb038q 34 15 supports support VBZ cord-266696-w9sb038q 34 16 the the DT cord-266696-w9sb038q 34 17 position position NN cord-266696-w9sb038q 34 18 that that IN cord-266696-w9sb038q 34 19 SARS SARS NNP cord-266696-w9sb038q 34 20 - - HYPH cord-266696-w9sb038q 34 21 CoV CoV NNP cord-266696-w9sb038q 34 22 damages damage NNS cord-266696-w9sb038q 34 23 lymphocytes lymphocyte NNS cord-266696-w9sb038q 34 24 . . . cord-266696-w9sb038q 35 1 Humoral Humoral NNP cord-266696-w9sb038q 35 2 immune immune JJ cord-266696-w9sb038q 35 3 response response NN cord-266696-w9sb038q 35 4 to to IN cord-266696-w9sb038q 35 5 SARS SARS NNP cord-266696-w9sb038q 35 6 - - HYPH cord-266696-w9sb038q 35 7 CoV CoV NNP cord-266696-w9sb038q 35 8 is be VBZ cord-266696-w9sb038q 35 9 not not RB cord-266696-w9sb038q 35 10 damaged damage VBN cord-266696-w9sb038q 35 11 in in IN cord-266696-w9sb038q 35 12 patients patient NNS cord-266696-w9sb038q 35 13 with with IN cord-266696-w9sb038q 35 14 SARS SARS NNP cord-266696-w9sb038q 35 15 . . . cord-266696-w9sb038q 36 1 Before before IN cord-266696-w9sb038q 36 2 in in IN cord-266696-w9sb038q 36 3 vitro vitro FW cord-266696-w9sb038q 36 4 and and CC cord-266696-w9sb038q 36 5 in in IN cord-266696-w9sb038q 36 6 vivo vivo NNP cord-266696-w9sb038q 36 7 cellular cellular JJ cord-266696-w9sb038q 36 8 immune immune JJ cord-266696-w9sb038q 36 9 responses response NNS cord-266696-w9sb038q 36 10 are be VBP cord-266696-w9sb038q 36 11 investigated investigate VBN cord-266696-w9sb038q 36 12 , , , cord-266696-w9sb038q 36 13 it -PRON- PRP cord-266696-w9sb038q 36 14 would would MD cord-266696-w9sb038q 36 15 be be VB cord-266696-w9sb038q 36 16 cautious cautious JJ cord-266696-w9sb038q 36 17 to to TO cord-266696-w9sb038q 36 18 conclude conclude VB cord-266696-w9sb038q 36 19 that that IN cord-266696-w9sb038q 36 20 the the DT cord-266696-w9sb038q 36 21 immune immune JJ cord-266696-w9sb038q 36 22 system system NN cord-266696-w9sb038q 36 23 is be VBZ cord-266696-w9sb038q 36 24 impaired impair VBN cord-266696-w9sb038q 36 25 in in IN cord-266696-w9sb038q 36 26 patients patient NNS cord-266696-w9sb038q 36 27 with with IN cord-266696-w9sb038q 36 28 SARS SARS NNP cord-266696-w9sb038q 36 29 . . . cord-266696-w9sb038q 37 1 [ [ -LRB- cord-266696-w9sb038q 37 2 3 3 CD cord-266696-w9sb038q 37 3 ] ] -RRB- cord-266696-w9sb038q 37 4 demonstrated demonstrate VBD cord-266696-w9sb038q 37 5 that that IN cord-266696-w9sb038q 37 6 , , , cord-266696-w9sb038q 37 7 in in IN cord-266696-w9sb038q 37 8 patients patient NNS cord-266696-w9sb038q 37 9 with with IN cord-266696-w9sb038q 37 10 SARS SARS NNP cord-266696-w9sb038q 37 11 , , , cord-266696-w9sb038q 37 12 lymphopenia lymphopenia NNP cord-266696-w9sb038q 37 13 was be VBD cord-266696-w9sb038q 37 14 observed observe VBN cord-266696-w9sb038q 37 15 in in IN cord-266696-w9sb038q 37 16 various various JJ cord-266696-w9sb038q 37 17 lymphoid lymphoid JJ cord-266696-w9sb038q 37 18 organs organ NNS cord-266696-w9sb038q 37 19 , , , cord-266696-w9sb038q 37 20 there there EX cord-266696-w9sb038q 37 21 were be VBD cord-266696-w9sb038q 37 22 scanty scanty JJ cord-266696-w9sb038q 37 23 numbers number NNS cord-266696-w9sb038q 37 24 of of IN cord-266696-w9sb038q 37 25 lymphocytes lymphocyte NNS cord-266696-w9sb038q 37 26 in in IN cord-266696-w9sb038q 37 27 exudates exudate NNS cord-266696-w9sb038q 37 28 from from IN cord-266696-w9sb038q 37 29 inflamed inflamed JJ cord-266696-w9sb038q 37 30 lungs lung NNS cord-266696-w9sb038q 37 31 , , , cord-266696-w9sb038q 37 32 and and CC cord-266696-w9sb038q 37 33 lymphocytosis lymphocytosis NNP cord-266696-w9sb038q 37 34 was be VBD cord-266696-w9sb038q 37 35 not not RB cord-266696-w9sb038q 37 36 found find VBN cord-266696-w9sb038q 37 37 in in IN cord-266696-w9sb038q 37 38 any any DT cord-266696-w9sb038q 37 39 organs organ NNS cord-266696-w9sb038q 37 40 . . . cord-266696-w9sb038q 38 1 In in IN cord-266696-w9sb038q 38 2 another another DT cord-266696-w9sb038q 38 3 article article NN cord-266696-w9sb038q 38 4 [ [ -LRB- cord-266696-w9sb038q 38 5 4 4 CD cord-266696-w9sb038q 38 6 ] ] -RRB- cord-266696-w9sb038q 38 7 cited cite VBN cord-266696-w9sb038q 38 8 by by IN cord-266696-w9sb038q 38 9 Zhou Zhou NNP cord-266696-w9sb038q 38 10 and and CC cord-266696-w9sb038q 38 11 Chen Chen NNP cord-266696-w9sb038q 38 12 [ [ -LRB- cord-266696-w9sb038q 38 13 1 1 CD cord-266696-w9sb038q 38 14 ] ] -RRB- cord-266696-w9sb038q 38 15 , , , cord-266696-w9sb038q 38 16 hemorrhagic hemorrhagic JJ cord-266696-w9sb038q 38 17 necrosis necrosis NN cord-266696-w9sb038q 38 18 and and CC cord-266696-w9sb038q 38 19 attenuation attenuation NN cord-266696-w9sb038q 38 20 of of IN cord-266696-w9sb038q 38 21 lymphocytes lymphocyte NNS cord-266696-w9sb038q 38 22 were be VBD cord-266696-w9sb038q 38 23 also also RB cord-266696-w9sb038q 38 24 evident evident JJ cord-266696-w9sb038q 38 25 in in IN cord-266696-w9sb038q 38 26 lymph lymph NN cord-266696-w9sb038q 38 27 nodes node NNS cord-266696-w9sb038q 38 28 and and CC cord-266696-w9sb038q 38 29 spleen spleen NN cord-266696-w9sb038q 38 30 specimens specimen NNS cord-266696-w9sb038q 38 31 obtained obtain VBN cord-266696-w9sb038q 38 32 from from IN cord-266696-w9sb038q 38 33 patients patient NNS cord-266696-w9sb038q 38 34 with with IN cord-266696-w9sb038q 38 35 SARS SARS NNP cord-266696-w9sb038q 38 36 , , , cord-266696-w9sb038q 38 37 which which WDT cord-266696-w9sb038q 38 38 is be VBZ cord-266696-w9sb038q 38 39 direct direct JJ cord-266696-w9sb038q 38 40 evidence evidence NN cord-266696-w9sb038q 38 41 of of IN cord-266696-w9sb038q 38 42 damaged damaged JJ cord-266696-w9sb038q 38 43 immune immune JJ cord-266696-w9sb038q 38 44 organs organ NNS cord-266696-w9sb038q 38 45 and and CC cord-266696-w9sb038q 38 46 tissues tissue NNS cord-266696-w9sb038q 38 47 in in IN cord-266696-w9sb038q 38 48 patients patient NNS cord-266696-w9sb038q 38 49 with with IN cord-266696-w9sb038q 38 50 SARS SARS NNP cord-266696-w9sb038q 38 51 . . . cord-266696-w9sb038q 39 1 On on IN cord-266696-w9sb038q 39 2 the the DT cord-266696-w9sb038q 39 3 basis basis NN cord-266696-w9sb038q 39 4 of of IN cord-266696-w9sb038q 39 5 these these DT cord-266696-w9sb038q 39 6 findings finding NNS cord-266696-w9sb038q 39 7 , , , cord-266696-w9sb038q 39 8 Lang Lang NNP cord-266696-w9sb038q 39 9 et et NNP cord-266696-w9sb038q 39 10 al al NNP cord-266696-w9sb038q 39 11 . . . cord-266696-w9sb038q 40 1 [ [ -LRB- cord-266696-w9sb038q 40 2 4 4 CD cord-266696-w9sb038q 40 3 ] ] -RRB- cord-266696-w9sb038q 40 4 concluded conclude VBD cord-266696-w9sb038q 40 5 that that IN cord-266696-w9sb038q 40 6 the the DT cord-266696-w9sb038q 40 7 severe severe JJ cord-266696-w9sb038q 40 8 damage damage NN cord-266696-w9sb038q 40 9 to to IN cord-266696-w9sb038q 40 10 the the DT cord-266696-w9sb038q 40 11 pulmonary pulmonary JJ cord-266696-w9sb038q 40 12 and and CC cord-266696-w9sb038q 40 13 immunological immunological JJ cord-266696-w9sb038q 40 14 systems system NNS cord-266696-w9sb038q 40 15 was be VBD cord-266696-w9sb038q 40 16 responsible responsible JJ cord-266696-w9sb038q 40 17 for for IN cord-266696-w9sb038q 40 18 the the DT cord-266696-w9sb038q 40 19 clinical clinical JJ cord-266696-w9sb038q 40 20 features feature NNS cord-266696-w9sb038q 40 21 of of IN cord-266696-w9sb038q 40 22 SARS SARS NNP cord-266696-w9sb038q 40 23 and and CC cord-266696-w9sb038q 40 24 might may MD cord-266696-w9sb038q 40 25 result result VB cord-266696-w9sb038q 40 26 in in IN cord-266696-w9sb038q 40 27 patient patient JJ cord-266696-w9sb038q 40 28 death death NN cord-266696-w9sb038q 40 29 [ [ -LRB- cord-266696-w9sb038q 40 30 4 4 CD cord-266696-w9sb038q 40 31 ] ] -RRB- cord-266696-w9sb038q 40 32 . . . cord-266696-w9sb038q 41 1 Ding Ding NNP cord-266696-w9sb038q 41 2 et et FW cord-266696-w9sb038q 41 3 al al NNP cord-266696-w9sb038q 41 4 . . . cord-266696-w9sb038q 42 1 [ [ -LRB- cord-266696-w9sb038q 42 2 5 5 CD cord-266696-w9sb038q 42 3 ] ] -RRB- cord-266696-w9sb038q 42 4 reached reach VBD cord-266696-w9sb038q 42 5 the the DT cord-266696-w9sb038q 42 6 same same JJ cord-266696-w9sb038q 42 7 conclusion conclusion NN cord-266696-w9sb038q 42 8 . . . cord-266696-w9sb038q 43 1 They -PRON- PRP cord-266696-w9sb038q 43 2 note note VBP cord-266696-w9sb038q 43 3 that that IN cord-266696-w9sb038q 43 4 " " `` cord-266696-w9sb038q 43 5 SARS SARS NNP cord-266696-w9sb038q 43 6 is be VBZ cord-266696-w9sb038q 43 7 a a DT cord-266696-w9sb038q 43 8 systemic systemic JJ cord-266696-w9sb038q 43 9 disease disease NN cord-266696-w9sb038q 43 10 that that WDT cord-266696-w9sb038q 43 11 injures injure VBZ cord-266696-w9sb038q 43 12 many many JJ cord-266696-w9sb038q 43 13 organs organ NNS cord-266696-w9sb038q 43 14 . . . cord-266696-w9sb038q 44 1 The the DT cord-266696-w9sb038q 44 2 lungs lung NNS cord-266696-w9sb038q 44 3 , , , cord-266696-w9sb038q 44 4 immune immune JJ cord-266696-w9sb038q 44 5 organs organ NNS cord-266696-w9sb038q 44 6 , , , cord-266696-w9sb038q 44 7 and and CC cord-266696-w9sb038q 44 8 systemic systemic JJ cord-266696-w9sb038q 44 9 small small JJ cord-266696-w9sb038q 44 10 vessels vessel NNS cord-266696-w9sb038q 44 11 are be VBP cord-266696-w9sb038q 44 12 the the DT cord-266696-w9sb038q 44 13 main main JJ cord-266696-w9sb038q 44 14 targets target NNS cord-266696-w9sb038q 44 15 of of IN cord-266696-w9sb038q 44 16 virus virus NN cord-266696-w9sb038q 44 17 attack attack NN cord-266696-w9sb038q 44 18 so so IN cord-266696-w9sb038q 44 19 that that IN cord-266696-w9sb038q 44 20 extensive extensive JJ cord-266696-w9sb038q 44 21 consolidation consolidation NN cord-266696-w9sb038q 44 22 of of IN cord-266696-w9sb038q 44 23 the the DT cord-266696-w9sb038q 44 24 lung lung NN cord-266696-w9sb038q 44 25 , , , cord-266696-w9sb038q 44 26 diffuse diffuse VB cord-266696-w9sb038q 44 27 alveolar alveolar JJ cord-266696-w9sb038q 44 28 damage damage NN cord-266696-w9sb038q 44 29 with with IN cord-266696-w9sb038q 44 30 hy hy NNP cord-266696-w9sb038q 44 31 - - HYPH cord-266696-w9sb038q 44 32 aline aline NNP cord-266696-w9sb038q 44 33 membrane membrane NN cord-266696-w9sb038q 44 34 formation formation NN cord-266696-w9sb038q 44 35 , , , cord-266696-w9sb038q 44 36 respiratory respiratory JJ cord-266696-w9sb038q 44 37 distress distress NN cord-266696-w9sb038q 44 38 , , , cord-266696-w9sb038q 44 39 and and CC cord-266696-w9sb038q 44 40 decreased decrease VBD cord-266696-w9sb038q 44 41 immune immune JJ cord-266696-w9sb038q 44 42 function function NN cord-266696-w9sb038q 44 43 are be VBP cord-266696-w9sb038q 44 44 the the DT cord-266696-w9sb038q 44 45 main main JJ cord-266696-w9sb038q 44 46 causes cause NNS cord-266696-w9sb038q 44 47 of of IN cord-266696-w9sb038q 44 48 death death NN cord-266696-w9sb038q 44 49 " " '' cord-266696-w9sb038q 44 50 [ [ -LRB- cord-266696-w9sb038q 44 51 5 5 CD cord-266696-w9sb038q 44 52 , , , cord-266696-w9sb038q 44 53 p. p. NN cord-266696-w9sb038q 44 54 282 282 CD cord-266696-w9sb038q 44 55 ] ] -RRB- cord-266696-w9sb038q 44 56 . . . cord-266696-w9sb038q 45 1 At at IN cord-266696-w9sb038q 45 2 the the DT cord-266696-w9sb038q 45 3 time time NN cord-266696-w9sb038q 45 4 of of IN cord-266696-w9sb038q 45 5 writing writing NN cord-266696-w9sb038q 45 6 , , , cord-266696-w9sb038q 45 7 there there EX cord-266696-w9sb038q 45 8 is be VBZ cord-266696-w9sb038q 45 9 still still RB cord-266696-w9sb038q 45 10 no no DT cord-266696-w9sb038q 45 11 evidence evidence NN cord-266696-w9sb038q 45 12 to to TO cord-266696-w9sb038q 45 13 support support VB cord-266696-w9sb038q 45 14 the the DT cord-266696-w9sb038q 45 15 view view NN cord-266696-w9sb038q 45 16 of of IN cord-266696-w9sb038q 45 17 Zhou Zhou NNP cord-266696-w9sb038q 45 18 and and CC cord-266696-w9sb038q 45 19 Chen Chen NNP cord-266696-w9sb038q 45 20 [ [ -LRB- cord-266696-w9sb038q 45 21 1 1 CD cord-266696-w9sb038q 45 22 ] ] -RRB- cord-266696-w9sb038q 45 23 that that IN cord-266696-w9sb038q 45 24 lymphopenia lymphopenia NNP cord-266696-w9sb038q 45 25 is be VBZ cord-266696-w9sb038q 45 26 due due JJ cord-266696-w9sb038q 45 27 to to IN cord-266696-w9sb038q 45 28 the the DT cord-266696-w9sb038q 45 29 redistribution redistribution NN cord-266696-w9sb038q 45 30 and and CC cord-266696-w9sb038q 45 31 migration migration NN cord-266696-w9sb038q 45 32 of of IN cord-266696-w9sb038q 45 33 lymphocytes lymphocyte NNS cord-266696-w9sb038q 45 34 . . . cord-266696-w9sb038q 46 1 With with IN cord-266696-w9sb038q 46 2 respect respect NN cord-266696-w9sb038q 46 3 to to IN cord-266696-w9sb038q 46 4 the the DT cord-266696-w9sb038q 46 5 expression expression NN cord-266696-w9sb038q 46 6 of of IN cord-266696-w9sb038q 46 7 lymphocytes lymphocyte NNS cord-266696-w9sb038q 46 8 and and CC cord-266696-w9sb038q 46 9 their -PRON- PRP$ cord-266696-w9sb038q 46 10 subsets subset NNS cord-266696-w9sb038q 46 11 , , , cord-266696-w9sb038q 46 12 Li Li NNP cord-266696-w9sb038q 46 13 et et NNP cord-266696-w9sb038q 46 14 al al NNP cord-266696-w9sb038q 46 15 . . . cord-266696-w9sb038q 47 1 [ [ -LRB- cord-266696-w9sb038q 47 2 6 6 CD cord-266696-w9sb038q 47 3 ] ] -RRB- cord-266696-w9sb038q 47 4 arrived arrive VBD cord-266696-w9sb038q 47 5 at at IN cord-266696-w9sb038q 47 6 a a DT cord-266696-w9sb038q 47 7 conclusion conclusion NN cord-266696-w9sb038q 47 8 identical identical JJ cord-266696-w9sb038q 47 9 to to IN cord-266696-w9sb038q 47 10 the the DT cord-266696-w9sb038q 47 11 one one NN cord-266696-w9sb038q 47 12 we -PRON- PRP cord-266696-w9sb038q 47 13 reported report VBD cord-266696-w9sb038q 47 14 [ [ -LRB- cord-266696-w9sb038q 47 15 7 7 CD cord-266696-w9sb038q 47 16 ] ] -RRB- cord-266696-w9sb038q 47 17 . . . cord-266696-w9sb038q 48 1 Therefore therefore RB cord-266696-w9sb038q 48 2 , , , cord-266696-w9sb038q 48 3 we -PRON- PRP cord-266696-w9sb038q 48 4 believe believe VBP cord-266696-w9sb038q 48 5 that that IN cord-266696-w9sb038q 48 6 the the DT cord-266696-w9sb038q 48 7 hypothesis hypothesis NN cord-266696-w9sb038q 48 8 that that IN cord-266696-w9sb038q 48 9 SARS SARS NNP cord-266696-w9sb038q 48 10 - - HYPH cord-266696-w9sb038q 48 11 CoV CoV NNP cord-266696-w9sb038q 48 12 may may MD cord-266696-w9sb038q 48 13 damage damage VB cord-266696-w9sb038q 48 14 the the DT cord-266696-w9sb038q 48 15 immune immune JJ cord-266696-w9sb038q 48 16 system system NN cord-266696-w9sb038q 48 17 might may MD cord-266696-w9sb038q 48 18 be be VB cord-266696-w9sb038q 48 19 supported support VBN cord-266696-w9sb038q 48 20 by by IN cord-266696-w9sb038q 48 21 recently recently RB cord-266696-w9sb038q 48 22 published publish VBN cord-266696-w9sb038q 48 23 studies study NNS cord-266696-w9sb038q 48 24 . . . cord-266696-w9sb038q 49 1 We -PRON- PRP cord-266696-w9sb038q 49 2 believe believe VBP cord-266696-w9sb038q 49 3 that that IN cord-266696-w9sb038q 49 4 Zhou Zhou NNP cord-266696-w9sb038q 49 5 and and CC cord-266696-w9sb038q 49 6 Chen Chen NNP cord-266696-w9sb038q 49 7 [ [ -LRB- cord-266696-w9sb038q 49 8 1 1 LS cord-266696-w9sb038q 49 9 ] ] -RRB- cord-266696-w9sb038q 49 10 need need VB cord-266696-w9sb038q 49 11 more more JJR cord-266696-w9sb038q 49 12 data datum NNS cord-266696-w9sb038q 49 13 to to TO cord-266696-w9sb038q 49 14 support support VB cord-266696-w9sb038q 49 15 their -PRON- PRP$ cord-266696-w9sb038q 49 16 conclusion conclusion NN cord-266696-w9sb038q 49 17 that that IN cord-266696-w9sb038q 49 18 the the DT cord-266696-w9sb038q 49 19 immune immune JJ cord-266696-w9sb038q 49 20 function function NN cord-266696-w9sb038q 49 21 of of IN cord-266696-w9sb038q 49 22 B b NN cord-266696-w9sb038q 49 23 cells cell NNS cord-266696-w9sb038q 49 24 in in IN cord-266696-w9sb038q 49 25 our -PRON- PRP$ cord-266696-w9sb038q 49 26 patients patient NNS cord-266696-w9sb038q 49 27 appeared appear VBD cord-266696-w9sb038q 49 28 not not RB cord-266696-w9sb038q 49 29 to to TO cord-266696-w9sb038q 49 30 be be VB cord-266696-w9sb038q 49 31 impaired impair VBN cord-266696-w9sb038q 49 32 because because IN cord-266696-w9sb038q 49 33 specific specific JJ cord-266696-w9sb038q 49 34 anti anti JJ cord-266696-w9sb038q 49 35 - - JJ cord-266696-w9sb038q 49 36 SARS SARS NNP cord-266696-w9sb038q 49 37 - - HYPH cord-266696-w9sb038q 49 38 CoV CoV NNP cord-266696-w9sb038q 49 39 could could MD cord-266696-w9sb038q 49 40 be be VB cord-266696-w9sb038q 49 41 detected detect VBN cord-266696-w9sb038q 49 42 as as RB cord-266696-w9sb038q 49 43 early early RB cord-266696-w9sb038q 49 44 as as IN cord-266696-w9sb038q 49 45 10 10 CD cord-266696-w9sb038q 49 46 days day NNS cord-266696-w9sb038q 49 47 after after IN cord-266696-w9sb038q 49 48 the the DT cord-266696-w9sb038q 49 49 onset onset NN cord-266696-w9sb038q 49 50 of of IN cord-266696-w9sb038q 49 51 illness illness NN cord-266696-w9sb038q 49 52 . . . cord-266696-w9sb038q 50 1 Although although IN cord-266696-w9sb038q 50 2 anti anti JJ cord-266696-w9sb038q 50 3 - - JJ cord-266696-w9sb038q 50 4 SARS SARS NNP cord-266696-w9sb038q 50 5 - - HYPH cord-266696-w9sb038q 50 6 CoV CoV NNP cord-266696-w9sb038q 50 7 was be VBD cord-266696-w9sb038q 50 8 observed observe VBN cord-266696-w9sb038q 50 9 in in IN cord-266696-w9sb038q 50 10 patients patient NNS cord-266696-w9sb038q 50 11 with with IN cord-266696-w9sb038q 50 12 SARS SARS NNP cord-266696-w9sb038q 50 13 , , , cord-266696-w9sb038q 50 14 it -PRON- PRP cord-266696-w9sb038q 50 15 was be VBD cord-266696-w9sb038q 50 16 not not RB cord-266696-w9sb038q 50 17 proper proper JJ cord-266696-w9sb038q 50 18 to to TO cord-266696-w9sb038q 50 19 conclude conclude VB cord-266696-w9sb038q 50 20 that that IN cord-266696-w9sb038q 50 21 B b NN cord-266696-w9sb038q 50 22 cells cell NNS cord-266696-w9sb038q 50 23 in in IN cord-266696-w9sb038q 50 24 these these DT cord-266696-w9sb038q 50 25 patients patient NNS cord-266696-w9sb038q 50 26 were be VBD cord-266696-w9sb038q 50 27 unimpaired unimpaired JJ cord-266696-w9sb038q 50 28 , , , cord-266696-w9sb038q 50 29 because because IN cord-266696-w9sb038q 50 30 the the DT cord-266696-w9sb038q 50 31 extent extent NN cord-266696-w9sb038q 50 32 of of IN cord-266696-w9sb038q 50 33 impairment impairment NN cord-266696-w9sb038q 50 34 might may MD cord-266696-w9sb038q 50 35 be be VB cord-266696-w9sb038q 50 36 different different JJ cord-266696-w9sb038q 50 37 and and CC cord-266696-w9sb038q 50 38 because because IN cord-266696-w9sb038q 50 39 the the DT cord-266696-w9sb038q 50 40 function function NN cord-266696-w9sb038q 50 41 of of IN cord-266696-w9sb038q 50 42 B b NN cord-266696-w9sb038q 50 43 cells cell NNS cord-266696-w9sb038q 50 44 was be VBD cord-266696-w9sb038q 50 45 not not RB cord-266696-w9sb038q 50 46 limited limit VBN cord-266696-w9sb038q 50 47 to to IN cord-266696-w9sb038q 50 48 the the DT cord-266696-w9sb038q 50 49 production production NN cord-266696-w9sb038q 50 50 of of IN cord-266696-w9sb038q 50 51 antibody antibody NN cord-266696-w9sb038q 50 52 . . . cord-266696-w9sb038q 51 1 The the DT cord-266696-w9sb038q 51 2 fact fact NN cord-266696-w9sb038q 51 3 that that IN cord-266696-w9sb038q 51 4 76 76 CD cord-266696-w9sb038q 51 5 % % NN cord-266696-w9sb038q 51 6 of of IN cord-266696-w9sb038q 51 7 our -PRON- PRP$ cord-266696-w9sb038q 51 8 patients patient NNS cord-266696-w9sb038q 51 9 with with IN cord-266696-w9sb038q 51 10 SARS SARS NNP cord-266696-w9sb038q 51 11 had have VBD cord-266696-w9sb038q 51 12 low low JJ cord-266696-w9sb038q 51 13 B b NN cord-266696-w9sb038q 51 14 cell cell NN cord-266696-w9sb038q 51 15 counts count NNS cord-266696-w9sb038q 51 16 could could MD cord-266696-w9sb038q 51 17 imply imply VB cord-266696-w9sb038q 51 18 that that IN cord-266696-w9sb038q 51 19 B b NN cord-266696-w9sb038q 51 20 cells cell NNS cord-266696-w9sb038q 51 21 were be VBD cord-266696-w9sb038q 51 22 damaged damage VBN cord-266696-w9sb038q 51 23 by by IN cord-266696-w9sb038q 51 24 SARS SARS NNP cord-266696-w9sb038q 51 25 - - HYPH cord-266696-w9sb038q 51 26 CoV CoV NNP cord-266696-w9sb038q 51 27 , , , cord-266696-w9sb038q 51 28 although although IN cord-266696-w9sb038q 51 29 the the DT cord-266696-w9sb038q 51 30 damage damage NN cord-266696-w9sb038q 51 31 was be VBD cord-266696-w9sb038q 51 32 not not RB cord-266696-w9sb038q 51 33 too too RB cord-266696-w9sb038q 51 34 severe severe JJ cord-266696-w9sb038q 51 35 to to TO cord-266696-w9sb038q 51 36 affect affect VB cord-266696-w9sb038q 51 37 the the DT cord-266696-w9sb038q 51 38 production production NN cord-266696-w9sb038q 51 39 of of IN cord-266696-w9sb038q 51 40 antibody antibody NN cord-266696-w9sb038q 51 41 . . . cord-266696-w9sb038q 52 1 There there EX cord-266696-w9sb038q 52 2 are be VBP cord-266696-w9sb038q 52 3 still still RB cord-266696-w9sb038q 52 4 too too RB cord-266696-w9sb038q 52 5 many many JJ cord-266696-w9sb038q 52 6 unanswered unanswered JJ cord-266696-w9sb038q 52 7 questions question NNS cord-266696-w9sb038q 52 8 about about IN cord-266696-w9sb038q 52 9 SARS SARS NNP cord-266696-w9sb038q 52 10 . . . cord-266696-w9sb038q 53 1 Although although IN cord-266696-w9sb038q 53 2 the the DT cord-266696-w9sb038q 53 3 incidence incidence NN cord-266696-w9sb038q 53 4 of of IN cord-266696-w9sb038q 53 5 SARS SARS NNP cord-266696-w9sb038q 53 6 has have VBZ cord-266696-w9sb038q 53 7 subsided subside VBN cord-266696-w9sb038q 53 8 in in IN cord-266696-w9sb038q 53 9 Beijing Beijing NNP cord-266696-w9sb038q 53 10 , , , cord-266696-w9sb038q 53 11 more more JJR cord-266696-w9sb038q 53 12 investigations investigation NNS cord-266696-w9sb038q 53 13 are be VBP cord-266696-w9sb038q 53 14 underway underway JJ cord-266696-w9sb038q 53 15 . . . cord-266696-w9sb038q 54 1 We -PRON- PRP cord-266696-w9sb038q 54 2 welcome welcome VBP cord-266696-w9sb038q 54 3 different different JJ cord-266696-w9sb038q 54 4 opinions opinion NNS cord-266696-w9sb038q 54 5 and and CC cord-266696-w9sb038q 54 6 suggestions suggestion NNS cord-266696-w9sb038q 54 7 as as IN cord-266696-w9sb038q 54 8 we -PRON- PRP cord-266696-w9sb038q 54 9 continue continue VBP cord-266696-w9sb038q 54 10 our -PRON- PRP$ cord-266696-w9sb038q 54 11 research research NN cord-266696-w9sb038q 54 12 . . . cord-266696-w9sb038q 55 1 Expression expression NN cord-266696-w9sb038q 55 2 of of IN cord-266696-w9sb038q 55 3 lymphocytes lymphocyte NNS cord-266696-w9sb038q 55 4 and and CC cord-266696-w9sb038q 55 5 lymphocyte lymphocyte NN cord-266696-w9sb038q 55 6 subsets subset NNS cord-266696-w9sb038q 55 7 in in IN cord-266696-w9sb038q 55 8 patients patient NNS cord-266696-w9sb038q 55 9 with with IN cord-266696-w9sb038q 55 10 severe severe JJ cord-266696-w9sb038q 55 11 acute acute JJ cord-266696-w9sb038q 55 12 respiratory respiratory JJ cord-266696-w9sb038q 55 13 syndrome syndrome NN cord-266696-w9sb038q 56 1 The the DT cord-266696-w9sb038q 56 2 clinical clinical JJ cord-266696-w9sb038q 56 3 pathology pathology NN cord-266696-w9sb038q 56 4 of of IN cord-266696-w9sb038q 56 5 severe severe JJ cord-266696-w9sb038q 56 6 acute acute JJ cord-266696-w9sb038q 56 7 respiratory respiratory JJ cord-266696-w9sb038q 56 8 syndrome syndrome NN cord-266696-w9sb038q 56 9 ( ( -LRB- cord-266696-w9sb038q 56 10 SARS SARS NNP cord-266696-w9sb038q 56 11 ) ) -RRB- cord-266696-w9sb038q 56 12 : : : cord-266696-w9sb038q 57 1 a a DT cord-266696-w9sb038q 57 2 report report NN cord-266696-w9sb038q 57 3 from from IN cord-266696-w9sb038q 57 4 China China NNP cord-266696-w9sb038q 57 5 Haematological Haematological NNP cord-266696-w9sb038q 57 6 manifestations manifestation NNS cord-266696-w9sb038q 57 7 in in IN cord-266696-w9sb038q 57 8 patients patient NNS cord-266696-w9sb038q 57 9 with with IN cord-266696-w9sb038q 57 10 severe severe JJ cord-266696-w9sb038q 57 11 acute acute JJ cord-266696-w9sb038q 57 12 respiratory respiratory JJ cord-266696-w9sb038q 57 13 syndrome syndrome NN cord-266696-w9sb038q 57 14 : : : cord-266696-w9sb038q 57 15 retrospective retrospective JJ cord-266696-w9sb038q 57 16 analysis analysis NN cord-266696-w9sb038q 58 1 Pathological pathological JJ cord-266696-w9sb038q 58 2 study study NN cord-266696-w9sb038q 58 3 on on IN cord-266696-w9sb038q 58 4 severe severe JJ cord-266696-w9sb038q 58 5 acute acute JJ cord-266696-w9sb038q 58 6 respiratory respiratory JJ cord-266696-w9sb038q 58 7 syndrome syndrome NN cord-266696-w9sb038q 58 8 SARS SARS NNP cord-266696-w9sb038q 58 9 - - HYPH cord-266696-w9sb038q 58 10 coronavirus coronavirus NN cord-266696-w9sb038q 58 11 replicates replicate VBZ cord-266696-w9sb038q 58 12 in in IN cord-266696-w9sb038q 58 13 mononuclear mononuclear JJ cord-266696-w9sb038q 58 14 cells cell NNS cord-266696-w9sb038q 58 15 of of IN cord-266696-w9sb038q 58 16 peripheral peripheral JJ cord-266696-w9sb038q 58 17 blood blood NN cord-266696-w9sb038q 58 18 ( ( -LRB- cord-266696-w9sb038q 58 19 PBMCs pbmc NNS cord-266696-w9sb038q 58 20 ) ) -RRB- cord-266696-w9sb038q 58 21 from from IN cord-266696-w9sb038q 58 22 SARS SARS NNP cord-266696-w9sb038q 58 23 patients patient NNS cord-266696-w9sb038q 58 24 Severe severe JJ cord-266696-w9sb038q 58 25 acute acute JJ cord-266696-w9sb038q 58 26 respiratory respiratory JJ cord-266696-w9sb038q 58 27 syndrome syndrome NN cord-266696-w9sb038q 58 28 ( ( -LRB- cord-266696-w9sb038q 58 29 SARS SARS NNP cord-266696-w9sb038q 58 30 ) ) -RRB- cord-266696-w9sb038q 58 31 in in IN cord-266696-w9sb038q 58 32 Singapore Singapore NNP cord-266696-w9sb038q 58 33 : : : cord-266696-w9sb038q 58 34 clinical clinical JJ cord-266696-w9sb038q 58 35 features feature NNS cord-266696-w9sb038q 58 36 of of IN cord-266696-w9sb038q 58 37 index index NN cord-266696-w9sb038q 58 38 patient patient NN cord-266696-w9sb038q 58 39 and and CC cord-266696-w9sb038q 58 40 initial initial JJ cord-266696-w9sb038q 58 41 contacts contact NNS cord-266696-w9sb038q 58 42 Clinical clinical JJ cord-266696-w9sb038q 58 43 features feature NNS cord-266696-w9sb038q 58 44 and and CC cord-266696-w9sb038q 58 45 short short JJ cord-266696-w9sb038q 58 46 - - HYPH cord-266696-w9sb038q 58 47 term term NN cord-266696-w9sb038q 58 48 outcomes outcome NNS cord-266696-w9sb038q 58 49 of of IN cord-266696-w9sb038q 58 50 144 144 CD cord-266696-w9sb038q 58 51 patients patient NNS cord-266696-w9sb038q 58 52 with with IN cord-266696-w9sb038q 58 53 SARS SARS NNP cord-266696-w9sb038q 58 54 in in IN cord-266696-w9sb038q 58 55 the the DT cord-266696-w9sb038q 58 56 greater great JJR cord-266696-w9sb038q 58 57 Toronto Toronto NNP cord-266696-w9sb038q 58 58 area area NN cord-266696-w9sb038q 58 59 Clinical clinical JJ cord-266696-w9sb038q 58 60 progression progression NN cord-266696-w9sb038q 58 61 and and CC cord-266696-w9sb038q 58 62 viral viral JJ cord-266696-w9sb038q 58 63 load load NN cord-266696-w9sb038q 58 64 in in IN cord-266696-w9sb038q 58 65 a a DT cord-266696-w9sb038q 58 66 community community NN cord-266696-w9sb038q 58 67 outbreak outbreak NN cord-266696-w9sb038q 58 68 of of IN cord-266696-w9sb038q 58 69 coronavirus coronavirus NN cord-266696-w9sb038q 58 70 - - HYPH cord-266696-w9sb038q 58 71 associated associate VBN cord-266696-w9sb038q 58 72 SARS SARS NNP cord-266696-w9sb038q 58 73 pneumonia pneumonia NN cord-266696-w9sb038q 58 74 : : : cord-266696-w9sb038q 58 75 a a DT cord-266696-w9sb038q 58 76 prospective prospective JJ cord-266696-w9sb038q 58 77 study study NN cord-266696-w9sb038q 58 78 Development Development NNP cord-266696-w9sb038q 58 79 of of IN cord-266696-w9sb038q 58 80 a a DT cord-266696-w9sb038q 58 81 standard standard JJ cord-266696-w9sb038q 58 82 treatment treatment NN cord-266696-w9sb038q 58 83 protocol protocol NN cord-266696-w9sb038q 58 84 for for IN cord-266696-w9sb038q 58 85 severe severe JJ cord-266696-w9sb038q 58 86 acute acute JJ cord-266696-w9sb038q 58 87 respiratory respiratory JJ cord-266696-w9sb038q 58 88 syndrome syndrome NN cord-266696-w9sb038q 58 89 Profile profile NN cord-266696-w9sb038q 58 90 of of IN cord-266696-w9sb038q 58 91 specific specific JJ cord-266696-w9sb038q 58 92 antibodies antibody NNS cord-266696-w9sb038q 58 93 to to IN cord-266696-w9sb038q 58 94 the the DT cord-266696-w9sb038q 58 95 SARS SARS NNP cord-266696-w9sb038q 58 96 - - HYPH cord-266696-w9sb038q 58 97 associated associate VBN cord-266696-w9sb038q 58 98 coronavirus coronavirus NN cord-266696-w9sb038q 59 1 Is be VBZ cord-266696-w9sb038q 59 2 the the DT cord-266696-w9sb038q 59 3 immune immune JJ cord-266696-w9sb038q 59 4 system system NN cord-266696-w9sb038q 59 5 impaired impair VBN cord-266696-w9sb038q 59 6 in in IN cord-266696-w9sb038q 59 7 patients patient NNS cord-266696-w9sb038q 59 8 with with IN cord-266696-w9sb038q 59 9 severe severe JJ cord-266696-w9sb038q 59 10 acute acute JJ cord-266696-w9sb038q 59 11 respiratory respiratory JJ cord-266696-w9sb038q 59 12 syndrome syndrome NN cord-266696-w9sb038q 59 13 SARS SARS NNP cord-266696-w9sb038q 59 14 - - HYPH cord-266696-w9sb038q 59 15 coronavirus coronavirus NN cord-266696-w9sb038q 59 16 replicates replicate VBZ cord-266696-w9sb038q 59 17 in in IN cord-266696-w9sb038q 59 18 mononuclear mononuclear JJ cord-266696-w9sb038q 59 19 cells cell NNS cord-266696-w9sb038q 59 20 of of IN cord-266696-w9sb038q 59 21 peripheral peripheral JJ cord-266696-w9sb038q 59 22 blood blood NN cord-266696-w9sb038q 59 23 ( ( -LRB- cord-266696-w9sb038q 59 24 PBMCs pbmc NNS cord-266696-w9sb038q 59 25 ) ) -RRB- cord-266696-w9sb038q 59 26 from from IN cord-266696-w9sb038q 59 27 SARS SARS NNP cord-266696-w9sb038q 59 28 patients patient NNS cord-266696-w9sb038q 60 1 Haematological Haematological NNP cord-266696-w9sb038q 60 2 manifestations manifestation NNS cord-266696-w9sb038q 60 3 in in IN cord-266696-w9sb038q 60 4 patients patient NNS cord-266696-w9sb038q 60 5 with with IN cord-266696-w9sb038q 60 6 severe severe JJ cord-266696-w9sb038q 60 7 acute acute JJ cord-266696-w9sb038q 60 8 respiratory respiratory JJ cord-266696-w9sb038q 60 9 syndrome syndrome NN cord-266696-w9sb038q 60 10 : : : cord-266696-w9sb038q 60 11 retrospective retrospective JJ cord-266696-w9sb038q 60 12 analysis analysis NN cord-266696-w9sb038q 61 1 Pathological pathological JJ cord-266696-w9sb038q 61 2 study study NN cord-266696-w9sb038q 61 3 on on IN cord-266696-w9sb038q 61 4 severe severe JJ cord-266696-w9sb038q 61 5 acute acute JJ cord-266696-w9sb038q 61 6 respiratory respiratory JJ cord-266696-w9sb038q 61 7 syndrome syndrome NN cord-266696-w9sb038q 62 1 The the DT cord-266696-w9sb038q 62 2 clinical clinical JJ cord-266696-w9sb038q 62 3 pathology pathology NN cord-266696-w9sb038q 62 4 of of IN cord-266696-w9sb038q 62 5 severe severe JJ cord-266696-w9sb038q 62 6 acute acute JJ cord-266696-w9sb038q 62 7 respiratory respiratory JJ cord-266696-w9sb038q 62 8 syndrome syndrome NN cord-266696-w9sb038q 62 9 ( ( -LRB- cord-266696-w9sb038q 62 10 SARS SARS NNP cord-266696-w9sb038q 62 11 ) ) -RRB- cord-266696-w9sb038q 62 12 : : : cord-266696-w9sb038q 63 1 a a DT cord-266696-w9sb038q 63 2 report report NN cord-266696-w9sb038q 63 3 from from IN cord-266696-w9sb038q 63 4 China China NNP cord-266696-w9sb038q 63 5 Rapid Rapid NNP cord-266696-w9sb038q 63 6 loss loss NN cord-266696-w9sb038q 63 7 of of IN cord-266696-w9sb038q 63 8 both both DT cord-266696-w9sb038q 63 9 CD4 CD4 NNP cord-266696-w9sb038q 63 10 + + CC cord-266696-w9sb038q 63 11 and and CC cord-266696-w9sb038q 63 12 CD8 CD8 NNP cord-266696-w9sb038q 63 13 + + CC cord-266696-w9sb038q 63 14 T T NNP cord-266696-w9sb038q 63 15 lymphocyte lymphocyte NN cord-266696-w9sb038q 63 16 subsets subset NNS cord-266696-w9sb038q 63 17 during during IN cord-266696-w9sb038q 63 18 the the DT cord-266696-w9sb038q 63 19 acute acute JJ cord-266696-w9sb038q 63 20 phase phase NN cord-266696-w9sb038q 63 21 of of IN cord-266696-w9sb038q 63 22 severe severe JJ cord-266696-w9sb038q 63 23 acute acute JJ cord-266696-w9sb038q 63 24 respiratory respiratory JJ cord-266696-w9sb038q 63 25 syndrome syndrome NN cord-266696-w9sb038q 63 26 Expression expression NN cord-266696-w9sb038q 63 27 of of IN cord-266696-w9sb038q 63 28 lymphocytes lymphocyte NNS cord-266696-w9sb038q 63 29 and and CC cord-266696-w9sb038q 63 30 lymphocyte lymphocyte NN cord-266696-w9sb038q 63 31 subsets subset NNS cord-266696-w9sb038q 63 32 in in IN cord-266696-w9sb038q 63 33 patients patient NNS cord-266696-w9sb038q 63 34 with with IN cord-266696-w9sb038q 63 35 severe severe JJ cord-266696-w9sb038q 63 36 acute acute JJ cord-266696-w9sb038q 63 37 respiratory respiratory JJ cord-266696-w9sb038q 63 38 syndrome syndrome NN cord-266696-w9sb038q 63 39 Beijing Beijing NNP cord-266696-w9sb038q 63 40 , , , cord-266696-w9sb038q 63 41 People People NNPS cord-266696-w9sb038q 63 42 's 's POS cord-266696-w9sb038q 63 43 Republic Republic NNP cord-266696-w9sb038q 63 44 of of IN cord-266696-w9sb038q 63 45 China China NNP