id sid tid token lemma pos cord-313499-8ijbesl8 1 1 key key JJ cord-313499-8ijbesl8 1 2 : : : cord-313499-8ijbesl8 1 3 cord-313499 cord-313499 NN cord-313499-8ijbesl8 1 4 - - HYPH cord-313499-8ijbesl8 1 5 8ijbesl8 8ijbesl8 CD cord-313499-8ijbesl8 1 6 authors author NNS cord-313499-8ijbesl8 1 7 : : : cord-313499-8ijbesl8 1 8 Stowell Stowell NNP cord-313499-8ijbesl8 1 9 , , , cord-313499-8ijbesl8 1 10 Sean Sean NNP cord-313499-8ijbesl8 1 11 ; ; : cord-313499-8ijbesl8 1 12 Guarner Guarner NNP cord-313499-8ijbesl8 1 13 , , , cord-313499-8ijbesl8 1 14 Jeannette Jeannette NNP cord-313499-8ijbesl8 1 15 title title NN cord-313499-8ijbesl8 1 16 : : : cord-313499-8ijbesl8 1 17 Role role NN cord-313499-8ijbesl8 1 18 of of IN cord-313499-8ijbesl8 1 19 serology serology NN cord-313499-8ijbesl8 1 20 in in IN cord-313499-8ijbesl8 1 21 the the DT cord-313499-8ijbesl8 1 22 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 1 23 pandemic pandemic NN cord-313499-8ijbesl8 1 24 date date NN cord-313499-8ijbesl8 1 25 : : : cord-313499-8ijbesl8 1 26 2020 2020 CD cord-313499-8ijbesl8 1 27 - - HYPH cord-313499-8ijbesl8 1 28 05 05 CD cord-313499-8ijbesl8 1 29 - - HYPH cord-313499-8ijbesl8 1 30 01 01 CD cord-313499-8ijbesl8 1 31 journal journal NN cord-313499-8ijbesl8 1 32 : : : cord-313499-8ijbesl8 2 1 Clin Clin NNP cord-313499-8ijbesl8 2 2 Infect infect VB cord-313499-8ijbesl8 2 3 Dis Dis NNP cord-313499-8ijbesl8 2 4 DOI doi NN cord-313499-8ijbesl8 2 5 : : : cord-313499-8ijbesl8 2 6 10.1093 10.1093 CD cord-313499-8ijbesl8 2 7 / / SYM cord-313499-8ijbesl8 2 8 cid cid NNP cord-313499-8ijbesl8 2 9 / / SYM cord-313499-8ijbesl8 2 10 ciaa510 ciaa510 NNP cord-313499-8ijbesl8 2 11 sha sha NNP cord-313499-8ijbesl8 2 12 : : : cord-313499-8ijbesl8 3 1 d8673db0439823ec6aab0ef13f470e04fd064e10 d8673db0439823ec6aab0ef13f470e04fd064e10 UH cord-313499-8ijbesl8 3 2 doc_id doc_id CD cord-313499-8ijbesl8 4 1 : : : cord-313499-8ijbesl8 4 2 313499 313499 CD cord-313499-8ijbesl8 4 3 cord_uid cord_uid FW cord-313499-8ijbesl8 4 4 : : : cord-313499-8ijbesl8 5 1 8ijbesl8 8ijbesl8 CD cord-313499-8ijbesl8 5 2 nan nan NNP cord-313499-8ijbesl8 6 1 In in IN cord-313499-8ijbesl8 6 2 this this DT cord-313499-8ijbesl8 6 3 issue issue NN cord-313499-8ijbesl8 6 4 of of IN cord-313499-8ijbesl8 6 5 Clinical clinical JJ cord-313499-8ijbesl8 6 6 Infections Infections NNPS cord-313499-8ijbesl8 6 7 Diseases Diseases NNPS cord-313499-8ijbesl8 6 8 , , , cord-313499-8ijbesl8 6 9 F F NNP cord-313499-8ijbesl8 6 10 Xiang Xiang NNP cord-313499-8ijbesl8 6 11 et et NNP cord-313499-8ijbesl8 6 12 al al NNP cord-313499-8ijbesl8 6 13 present present VB cord-313499-8ijbesl8 6 14 a a DT cord-313499-8ijbesl8 6 15 serologic serologic JJ cord-313499-8ijbesl8 6 16 study study NN cord-313499-8ijbesl8 6 17 of of IN cord-313499-8ijbesl8 6 18 85 85 CD cord-313499-8ijbesl8 6 19 nucleic nucleic JJ cord-313499-8ijbesl8 6 20 acid acid NN cord-313499-8ijbesl8 6 21 test test NN cord-313499-8ijbesl8 6 22 ( ( -LRB- cord-313499-8ijbesl8 6 23 NAT NAT NNP cord-313499-8ijbesl8 6 24 ) ) -RRB- cord-313499-8ijbesl8 6 25 SARS SARS NNP cord-313499-8ijbesl8 6 26 - - HYPH cord-313499-8ijbesl8 6 27 CoV-2 CoV-2 NNP cord-313499-8ijbesl8 6 28 positive positive JJ cord-313499-8ijbesl8 6 29 patients patient NNS cord-313499-8ijbesl8 6 30 and and CC cord-313499-8ijbesl8 6 31 24 24 CD cord-313499-8ijbesl8 6 32 NAT NAT NNP cord-313499-8ijbesl8 6 33 negative negative JJ cord-313499-8ijbesl8 6 34 patients patient NNS cord-313499-8ijbesl8 6 35 who who WP cord-313499-8ijbesl8 6 36 had have VBD cord-313499-8ijbesl8 6 37 symptoms symptom NNS cord-313499-8ijbesl8 6 38 suspicious suspicious JJ cord-313499-8ijbesl8 6 39 for for IN cord-313499-8ijbesl8 6 40 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 6 41 1 1 CD cord-313499-8ijbesl8 6 42 . . . cord-313499-8ijbesl8 7 1 Sixty Sixty NNP cord-313499-8ijbesl8 7 2 controls control NNS cord-313499-8ijbesl8 7 3 were be VBD cord-313499-8ijbesl8 7 4 also also RB cord-313499-8ijbesl8 7 5 evaluated evaluate VBN cord-313499-8ijbesl8 7 6 and and CC cord-313499-8ijbesl8 7 7 included include VBD cord-313499-8ijbesl8 7 8 healthy healthy JJ cord-313499-8ijbesl8 7 9 healthcare healthcare NN cord-313499-8ijbesl8 7 10 staff staff NN cord-313499-8ijbesl8 7 11 and and CC cord-313499-8ijbesl8 7 12 patients patient NNS cord-313499-8ijbesl8 7 13 with with IN cord-313499-8ijbesl8 7 14 a a DT cord-313499-8ijbesl8 7 15 variety variety NN cord-313499-8ijbesl8 7 16 of of IN cord-313499-8ijbesl8 7 17 diseases disease NNS cord-313499-8ijbesl8 7 18 from from IN cord-313499-8ijbesl8 7 19 bacterial bacterial JJ cord-313499-8ijbesl8 7 20 pneumonia pneumonia NN cord-313499-8ijbesl8 7 21 to to IN cord-313499-8ijbesl8 7 22 lung lung NN cord-313499-8ijbesl8 7 23 cancer cancer NN cord-313499-8ijbesl8 7 24 . . . cord-313499-8ijbesl8 8 1 Serological serological JJ cord-313499-8ijbesl8 8 2 testing testing NN cord-313499-8ijbesl8 8 3 consisted consist VBD cord-313499-8ijbesl8 8 4 of of IN cord-313499-8ijbesl8 8 5 an an DT cord-313499-8ijbesl8 8 6 enzyme enzyme NN cord-313499-8ijbesl8 8 7 linked link VBN cord-313499-8ijbesl8 8 8 immunosorbent immunosorbent JJ cord-313499-8ijbesl8 8 9 assay assay NN cord-313499-8ijbesl8 8 10 designed design VBN cord-313499-8ijbesl8 8 11 to to TO cord-313499-8ijbesl8 8 12 detect detect VB cord-313499-8ijbesl8 8 13 IgM IgM NNP cord-313499-8ijbesl8 8 14 and and CC cord-313499-8ijbesl8 8 15 IgG IgG NNP cord-313499-8ijbesl8 8 16 antibodies antibody NNS cord-313499-8ijbesl8 8 17 against against IN cord-313499-8ijbesl8 8 18 the the DT cord-313499-8ijbesl8 8 19 N N NNP cord-313499-8ijbesl8 8 20 protein protein NN cord-313499-8ijbesl8 8 21 of of IN cord-313499-8ijbesl8 8 22 SARS SARS NNP cord-313499-8ijbesl8 8 23 - - HYPH cord-313499-8ijbesl8 8 24 CoV-2 CoV-2 NNP cord-313499-8ijbesl8 8 25 . . . cord-313499-8ijbesl8 9 1 Serial serial JJ cord-313499-8ijbesl8 9 2 examination examination NN cord-313499-8ijbesl8 9 3 of of IN cord-313499-8ijbesl8 9 4 COVID-19 covid-19 JJ cord-313499-8ijbesl8 9 5 patients patient NNS cord-313499-8ijbesl8 9 6 resulted result VBD cord-313499-8ijbesl8 9 7 in in IN cord-313499-8ijbesl8 9 8 IgM IgM NNP cord-313499-8ijbesl8 9 9 seroreactivity seroreactivity NN cord-313499-8ijbesl8 9 10 by by IN cord-313499-8ijbesl8 9 11 day day NN cord-313499-8ijbesl8 9 12 4 4 CD cord-313499-8ijbesl8 9 13 post post NN cord-313499-8ijbesl8 9 14 symptom symptom NN cord-313499-8ijbesl8 9 15 onset onset NN cord-313499-8ijbesl8 9 16 , , , cord-313499-8ijbesl8 9 17 which which WDT cord-313499-8ijbesl8 9 18 peaked peak VBD cord-313499-8ijbesl8 9 19 by by IN cord-313499-8ijbesl8 9 20 day day NN cord-313499-8ijbesl8 9 21 9 9 CD cord-313499-8ijbesl8 9 22 . . . cord-313499-8ijbesl8 10 1 In in IN cord-313499-8ijbesl8 10 2 contrast contrast NN cord-313499-8ijbesl8 10 3 , , , cord-313499-8ijbesl8 10 4 IgG IgG NNP cord-313499-8ijbesl8 10 5 sharply sharply RB cord-313499-8ijbesl8 10 6 increased increase VBD cord-313499-8ijbesl8 10 7 12 12 CD cord-313499-8ijbesl8 10 8 days day NNS cord-313499-8ijbesl8 10 9 after after IN cord-313499-8ijbesl8 10 10 symptom symptom NN cord-313499-8ijbesl8 10 11 onset onset NN cord-313499-8ijbesl8 10 12 ; ; : cord-313499-8ijbesl8 10 13 all all DT cord-313499-8ijbesl8 10 14 NAT NAT NNP cord-313499-8ijbesl8 10 15 positive positive JJ cord-313499-8ijbesl8 10 16 patients patient NNS cord-313499-8ijbesl8 10 17 were be VBD cord-313499-8ijbesl8 10 18 positive positive JJ cord-313499-8ijbesl8 10 19 for for IN cord-313499-8ijbesl8 10 20 IgG IgG NNP cord-313499-8ijbesl8 11 1 30 30 CD cord-313499-8ijbesl8 11 2 days day NNS cord-313499-8ijbesl8 11 3 post post VBP cord-313499-8ijbesl8 11 4 symptom symptom NN cord-313499-8ijbesl8 11 5 onset onset NN cord-313499-8ijbesl8 11 6 . . . cord-313499-8ijbesl8 12 1 In in IN cord-313499-8ijbesl8 12 2 patients patient NNS cord-313499-8ijbesl8 12 3 with with IN cord-313499-8ijbesl8 12 4 suspected suspect VBN cord-313499-8ijbesl8 12 5 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 12 6 who who WP cord-313499-8ijbesl8 12 7 tested test VBD cord-313499-8ijbesl8 12 8 NAT NAT NNP cord-313499-8ijbesl8 12 9 negative negative JJ cord-313499-8ijbesl8 12 10 , , , cord-313499-8ijbesl8 12 11 IgM IgM NNP cord-313499-8ijbesl8 12 12 antibodies antibody NNS cord-313499-8ijbesl8 12 13 were be VBD cord-313499-8ijbesl8 12 14 detected detect VBN cord-313499-8ijbesl8 12 15 in in IN cord-313499-8ijbesl8 12 16 87.5 87.5 CD cord-313499-8ijbesl8 12 17 % % NN cord-313499-8ijbesl8 12 18 and and CC cord-313499-8ijbesl8 12 19 IgG IgG NNP cord-313499-8ijbesl8 12 20 was be VBD cord-313499-8ijbesl8 12 21 present present JJ cord-313499-8ijbesl8 12 22 in in IN cord-313499-8ijbesl8 12 23 70.8 70.8 CD cord-313499-8ijbesl8 12 24 % % NN cord-313499-8ijbesl8 12 25 . . . cord-313499-8ijbesl8 13 1 In in IN cord-313499-8ijbesl8 13 2 contrast contrast NN cord-313499-8ijbesl8 13 3 , , , cord-313499-8ijbesl8 13 4 only only RB cord-313499-8ijbesl8 13 5 3 3 CD cord-313499-8ijbesl8 13 6 individuals individual NNS cord-313499-8ijbesl8 13 7 in in IN cord-313499-8ijbesl8 13 8 the the DT cord-313499-8ijbesl8 13 9 control control NN cord-313499-8ijbesl8 13 10 group group NN cord-313499-8ijbesl8 13 11 tested test VBD cord-313499-8ijbesl8 13 12 positive positive JJ cord-313499-8ijbesl8 13 13 for for IN cord-313499-8ijbesl8 13 14 IgG IgG NNP cord-313499-8ijbesl8 13 15 but but CC cord-313499-8ijbesl8 13 16 IgM IgM NNP cord-313499-8ijbesl8 13 17 positivity positivity NNP cord-313499-8ijbesl8 13 18 was be VBD cord-313499-8ijbesl8 13 19 not not RB cord-313499-8ijbesl8 13 20 observed observe VBN cord-313499-8ijbesl8 13 21 . . . cord-313499-8ijbesl8 14 1 The the DT cord-313499-8ijbesl8 14 2 authors author NNS cord-313499-8ijbesl8 14 3 calculated calculate VBD cord-313499-8ijbesl8 14 4 a a DT cord-313499-8ijbesl8 14 5 sensitivity sensitivity NN cord-313499-8ijbesl8 14 6 for for IN cord-313499-8ijbesl8 14 7 diagnosis diagnosis NN cord-313499-8ijbesl8 14 8 of of IN cord-313499-8ijbesl8 14 9 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 14 10 using use VBG cord-313499-8ijbesl8 14 11 IgM IgM NNP cord-313499-8ijbesl8 14 12 of of IN cord-313499-8ijbesl8 14 13 77.3 77.3 CD cord-313499-8ijbesl8 14 14 % % NN cord-313499-8ijbesl8 14 15 and and CC cord-313499-8ijbesl8 14 16 a a DT cord-313499-8ijbesl8 14 17 specificity specificity NN cord-313499-8ijbesl8 14 18 of of IN cord-313499-8ijbesl8 14 19 100 100 CD cord-313499-8ijbesl8 14 20 % % NN cord-313499-8ijbesl8 14 21 while while IN cord-313499-8ijbesl8 14 22 for for IN cord-313499-8ijbesl8 14 23 IgG igg NN cord-313499-8ijbesl8 14 24 the the DT cord-313499-8ijbesl8 14 25 sensitivity sensitivity NN cord-313499-8ijbesl8 14 26 was be VBD cord-313499-8ijbesl8 14 27 higher high JJR cord-313499-8ijbesl8 14 28 at at IN cord-313499-8ijbesl8 14 29 83.3 83.3 CD cord-313499-8ijbesl8 14 30 % % NN cord-313499-8ijbesl8 14 31 and and CC cord-313499-8ijbesl8 14 32 the the DT cord-313499-8ijbesl8 14 33 specificity specificity NN cord-313499-8ijbesl8 14 34 was be VBD cord-313499-8ijbesl8 14 35 95 95 CD cord-313499-8ijbesl8 14 36 % % NN cord-313499-8ijbesl8 14 37 . . . cord-313499-8ijbesl8 15 1 This this DT cord-313499-8ijbesl8 15 2 article article NN cord-313499-8ijbesl8 15 3 highlights highlight VBZ cord-313499-8ijbesl8 15 4 a a DT cord-313499-8ijbesl8 15 5 fundamental fundamental JJ cord-313499-8ijbesl8 15 6 challenge challenge NN cord-313499-8ijbesl8 15 7 clinicians clinician NNS cord-313499-8ijbesl8 15 8 face face VBP cord-313499-8ijbesl8 16 1 when when WRB cord-313499-8ijbesl8 16 2 patients patient NNS cord-313499-8ijbesl8 16 3 present present JJ cord-313499-8ijbesl8 16 4 with with IN cord-313499-8ijbesl8 16 5 COVID-19 covid-19 JJ cord-313499-8ijbesl8 16 6 symptoms symptom NNS cord-313499-8ijbesl8 16 7 yet yet RB cord-313499-8ijbesl8 16 8 are be VBP cord-313499-8ijbesl8 16 9 NAT NAT NNP cord-313499-8ijbesl8 16 10 negative negative JJ cord-313499-8ijbesl8 16 11 , , , cord-313499-8ijbesl8 16 12 sometimes sometimes RB cord-313499-8ijbesl8 16 13 even even RB cord-313499-8ijbesl8 16 14 with with IN cord-313499-8ijbesl8 16 15 repeated repeat VBN cord-313499-8ijbesl8 16 16 NAT NAT NNP cord-313499-8ijbesl8 16 17 testing testing NN cord-313499-8ijbesl8 16 18 . . . cord-313499-8ijbesl8 17 1 As as IN cord-313499-8ijbesl8 17 2 laboratory laboratory NN cord-313499-8ijbesl8 17 3 medicine medicine NN cord-313499-8ijbesl8 17 4 physicians physician NNS cord-313499-8ijbesl8 17 5 , , , cord-313499-8ijbesl8 17 6 we -PRON- PRP cord-313499-8ijbesl8 17 7 understand understand VBP cord-313499-8ijbesl8 17 8 this this DT cord-313499-8ijbesl8 17 9 dilemma dilemma NN cord-313499-8ijbesl8 17 10 and and CC cord-313499-8ijbesl8 17 11 know know VB cord-313499-8ijbesl8 17 12 that that IN cord-313499-8ijbesl8 17 13 preanalytical preanalytical JJ cord-313499-8ijbesl8 17 14 variables variable NNS cord-313499-8ijbesl8 17 15 can can MD cord-313499-8ijbesl8 17 16 frequently frequently RB cord-313499-8ijbesl8 17 17 underlie underlie VB cord-313499-8ijbesl8 17 18 inaccurate inaccurate JJ cord-313499-8ijbesl8 17 19 results result NNS cord-313499-8ijbesl8 17 20 for for IN cord-313499-8ijbesl8 17 21 all all DT cord-313499-8ijbesl8 17 22 tests test NNS cord-313499-8ijbesl8 17 23 . . . cord-313499-8ijbesl8 18 1 In in IN cord-313499-8ijbesl8 18 2 the the DT cord-313499-8ijbesl8 18 3 case case NN cord-313499-8ijbesl8 18 4 of of IN cord-313499-8ijbesl8 18 5 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 18 6 NAT NAT NNP cord-313499-8ijbesl8 18 7 , , , cord-313499-8ijbesl8 18 8 preanalytical preanalytical JJ cord-313499-8ijbesl8 18 9 variables variable NNS cord-313499-8ijbesl8 18 10 can can MD cord-313499-8ijbesl8 18 11 include include VB cord-313499-8ijbesl8 18 12 , , , cord-313499-8ijbesl8 18 13 but but CC cord-313499-8ijbesl8 18 14 are be VBP cord-313499-8ijbesl8 18 15 not not RB cord-313499-8ijbesl8 18 16 limited limited JJ cord-313499-8ijbesl8 18 17 to to IN cord-313499-8ijbesl8 18 18 , , , cord-313499-8ijbesl8 18 19 inconsistency inconsistency NN cord-313499-8ijbesl8 18 20 in in IN cord-313499-8ijbesl8 18 21 obtaining obtain VBG cord-313499-8ijbesl8 18 22 nasopharyngeal nasopharyngeal JJ cord-313499-8ijbesl8 18 23 swabs swab NNS cord-313499-8ijbesl8 18 24 , , , cord-313499-8ijbesl8 18 25 the the DT cord-313499-8ijbesl8 18 26 different different JJ cord-313499-8ijbesl8 18 27 swabs swab NNS cord-313499-8ijbesl8 18 28 and and CC cord-313499-8ijbesl8 18 29 transport transport NN cord-313499-8ijbesl8 18 30 media medium NNS cord-313499-8ijbesl8 18 31 used use VBN cord-313499-8ijbesl8 18 32 , , , cord-313499-8ijbesl8 18 33 time time NN cord-313499-8ijbesl8 18 34 and and CC cord-313499-8ijbesl8 18 35 temperature temperature NN cord-313499-8ijbesl8 18 36 of of IN cord-313499-8ijbesl8 18 37 specimen specimen JJ cord-313499-8ijbesl8 18 38 transport transport NN cord-313499-8ijbesl8 18 39 , , , cord-313499-8ijbesl8 18 40 and and CC cord-313499-8ijbesl8 18 41 possible possible JJ cord-313499-8ijbesl8 18 42 inhibitors inhibitor NNS cord-313499-8ijbesl8 18 43 to to IN cord-313499-8ijbesl8 18 44 nucleic nucleic JJ cord-313499-8ijbesl8 18 45 acid acid NN cord-313499-8ijbesl8 18 46 detection detection NN cord-313499-8ijbesl8 18 47 in in IN cord-313499-8ijbesl8 18 48 the the DT cord-313499-8ijbesl8 18 49 sample sample NN cord-313499-8ijbesl8 18 50 . . . cord-313499-8ijbesl8 19 1 In in IN cord-313499-8ijbesl8 19 2 addition addition NN cord-313499-8ijbesl8 19 3 , , , cord-313499-8ijbesl8 19 4 there there EX cord-313499-8ijbesl8 19 5 are be VBP cord-313499-8ijbesl8 19 6 likely likely JJ cord-313499-8ijbesl8 19 7 analytical analytical JJ cord-313499-8ijbesl8 19 8 variables variable NNS cord-313499-8ijbesl8 19 9 that that WDT cord-313499-8ijbesl8 19 10 can can MD cord-313499-8ijbesl8 19 11 be be VB cord-313499-8ijbesl8 19 12 explained explain VBN cord-313499-8ijbesl8 19 13 by by IN cord-313499-8ijbesl8 19 14 inherent inherent JJ cord-313499-8ijbesl8 19 15 differences difference NNS cord-313499-8ijbesl8 19 16 in in IN cord-313499-8ijbesl8 19 17 the the DT cord-313499-8ijbesl8 19 18 ability ability NN cord-313499-8ijbesl8 19 19 of of IN cord-313499-8ijbesl8 19 20 various various JJ cord-313499-8ijbesl8 19 21 NAT NAT NNP cord-313499-8ijbesl8 19 22 platforms platform NNS cord-313499-8ijbesl8 19 23 to to TO cord-313499-8ijbesl8 19 24 detect detect VB cord-313499-8ijbesl8 19 25 SARS SARS NNP cord-313499-8ijbesl8 19 26 - - HYPH cord-313499-8ijbesl8 19 27 CoV-2 CoV-2 NNP cord-313499-8ijbesl8 19 28 . . . cord-313499-8ijbesl8 20 1 Importantly importantly RB cord-313499-8ijbesl8 20 2 , , , cord-313499-8ijbesl8 20 3 a a DT cord-313499-8ijbesl8 20 4 lack lack NN cord-313499-8ijbesl8 20 5 of of IN cord-313499-8ijbesl8 20 6 understanding understanding NN cord-313499-8ijbesl8 20 7 regarding regard VBG cord-313499-8ijbesl8 20 8 the the DT cord-313499-8ijbesl8 20 9 frequency frequency NN cord-313499-8ijbesl8 20 10 and and CC cord-313499-8ijbesl8 20 11 variability variability NN cord-313499-8ijbesl8 20 12 of of IN cord-313499-8ijbesl8 20 13 viral viral JJ cord-313499-8ijbesl8 20 14 shedding shedding NN cord-313499-8ijbesl8 20 15 in in IN cord-313499-8ijbesl8 20 16 patients patient NNS cord-313499-8ijbesl8 20 17 with with IN cord-313499-8ijbesl8 20 18 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 20 19 also also RB cord-313499-8ijbesl8 20 20 makes make VBZ cord-313499-8ijbesl8 20 21 it -PRON- PRP cord-313499-8ijbesl8 20 22 difficult difficult JJ cord-313499-8ijbesl8 20 23 to to TO cord-313499-8ijbesl8 20 24 decipher decipher VB cord-313499-8ijbesl8 20 25 how how WRB cord-313499-8ijbesl8 20 26 these these DT cord-313499-8ijbesl8 20 27 variables variable NNS cord-313499-8ijbesl8 20 28 may may MD cord-313499-8ijbesl8 20 29 also also RB cord-313499-8ijbesl8 20 30 contribute contribute VB cord-313499-8ijbesl8 20 31 to to IN cord-313499-8ijbesl8 20 32 false false JJ cord-313499-8ijbesl8 20 33 negative negative JJ cord-313499-8ijbesl8 20 34 results result NNS cord-313499-8ijbesl8 20 35 . . . cord-313499-8ijbesl8 21 1 Although although IN cord-313499-8ijbesl8 21 2 NAT NAT NNP cord-313499-8ijbesl8 21 3 diagnostic diagnostic JJ cord-313499-8ijbesl8 21 4 testing testing NN cord-313499-8ijbesl8 21 5 continues continue VBZ cord-313499-8ijbesl8 21 6 to to TO cord-313499-8ijbesl8 21 7 become become VB cord-313499-8ijbesl8 21 8 a a DT cord-313499-8ijbesl8 21 9 common common JJ cord-313499-8ijbesl8 21 10 approach approach NN cord-313499-8ijbesl8 21 11 to to IN cord-313499-8ijbesl8 21 12 diagnosing diagnose VBG cord-313499-8ijbesl8 21 13 infectious infectious JJ cord-313499-8ijbesl8 21 14 diseases disease NNS cord-313499-8ijbesl8 21 15 in in IN cord-313499-8ijbesl8 21 16 general general JJ cord-313499-8ijbesl8 21 17 , , , cord-313499-8ijbesl8 21 18 serology serology NN cord-313499-8ijbesl8 21 19 preceded precede VBD cord-313499-8ijbesl8 21 20 NAT NAT NNP cord-313499-8ijbesl8 21 21 testing testing NN cord-313499-8ijbesl8 21 22 by by IN cord-313499-8ijbesl8 21 23 many many JJ cord-313499-8ijbesl8 21 24 decades decade NNS cord-313499-8ijbesl8 21 25 and and CC cord-313499-8ijbesl8 21 26 still still RB cord-313499-8ijbesl8 21 27 serves serve VBZ cord-313499-8ijbesl8 21 28 as as IN cord-313499-8ijbesl8 21 29 the the DT cord-313499-8ijbesl8 21 30 primary primary JJ cord-313499-8ijbesl8 21 31 diagnostic diagnostic JJ cord-313499-8ijbesl8 21 32 tool tool NN cord-313499-8ijbesl8 21 33 for for IN cord-313499-8ijbesl8 21 34 many many JJ cord-313499-8ijbesl8 21 35 diseases disease NNS cord-313499-8ijbesl8 21 36 , , , cord-313499-8ijbesl8 21 37 including include VBG cord-313499-8ijbesl8 21 38 HIV HIV NNP cord-313499-8ijbesl8 21 39 , , , cord-313499-8ijbesl8 21 40 hepatitis hepatitis NN cord-313499-8ijbesl8 21 41 B B NNP cord-313499-8ijbesl8 21 42 and and CC cord-313499-8ijbesl8 21 43 C. C. NNP cord-313499-8ijbesl8 22 1 This this DT cord-313499-8ijbesl8 22 2 is be VBZ cord-313499-8ijbesl8 22 3 in in IN cord-313499-8ijbesl8 22 4 part part NN cord-313499-8ijbesl8 22 5 due due JJ cord-313499-8ijbesl8 22 6 to to TO cord-313499-8ijbesl8 22 7 cost cost VB cord-313499-8ijbesl8 22 8 and and CC cord-313499-8ijbesl8 22 9 because because IN cord-313499-8ijbesl8 22 10 NAT NAT NNP cord-313499-8ijbesl8 22 11 testing testing NN cord-313499-8ijbesl8 22 12 remains remain VBZ cord-313499-8ijbesl8 22 13 less less RBR cord-313499-8ijbesl8 22 14 sensitive sensitive JJ cord-313499-8ijbesl8 22 15 for for IN cord-313499-8ijbesl8 22 16 some some DT cord-313499-8ijbesl8 22 17 pathogens pathogen NNS cord-313499-8ijbesl8 22 18 , , , cord-313499-8ijbesl8 22 19 as as IN cord-313499-8ijbesl8 22 20 occurs occur VBZ cord-313499-8ijbesl8 22 21 in in IN cord-313499-8ijbesl8 22 22 syphilis syphili NNS cord-313499-8ijbesl8 22 23 . . . cord-313499-8ijbesl8 23 1 Different different JJ cord-313499-8ijbesl8 23 2 strategies strategy NNS cord-313499-8ijbesl8 23 3 are be VBP cord-313499-8ijbesl8 23 4 used use VBN cord-313499-8ijbesl8 23 5 for for IN cord-313499-8ijbesl8 23 6 diagnosis diagnosis NN cord-313499-8ijbesl8 23 7 by by IN cord-313499-8ijbesl8 23 8 serological serological JJ cord-313499-8ijbesl8 23 9 methods method NNS cord-313499-8ijbesl8 23 10 , , , cord-313499-8ijbesl8 23 11 for for IN cord-313499-8ijbesl8 23 12 example example NN cord-313499-8ijbesl8 23 13 , , , cord-313499-8ijbesl8 23 14 in in IN cord-313499-8ijbesl8 23 15 leptospirosis leptospirosis NN cord-313499-8ijbesl8 23 16 a a DT cord-313499-8ijbesl8 23 17 fourfold fourfold JJ cord-313499-8ijbesl8 23 18 increase increase NN cord-313499-8ijbesl8 23 19 in in IN cord-313499-8ijbesl8 23 20 IgG igg NN cord-313499-8ijbesl8 23 21 in in IN cord-313499-8ijbesl8 23 22 convalescent convalescent JJ cord-313499-8ijbesl8 23 23 versus versus IN cord-313499-8ijbesl8 23 24 acute acute JJ cord-313499-8ijbesl8 23 25 serum serum NN cord-313499-8ijbesl8 23 26 frequently frequently RB cord-313499-8ijbesl8 23 27 helps help VBZ cord-313499-8ijbesl8 23 28 determine determine VB cord-313499-8ijbesl8 23 29 the the DT cord-313499-8ijbesl8 23 30 diagnosis diagnosis NN cord-313499-8ijbesl8 23 31 . . . cord-313499-8ijbesl8 24 1 In in IN cord-313499-8ijbesl8 24 2 contrast contrast NN cord-313499-8ijbesl8 24 3 , , , cord-313499-8ijbesl8 24 4 to to TO cord-313499-8ijbesl8 24 5 diagnose diagnose VB cord-313499-8ijbesl8 24 6 dengue dengue NN cord-313499-8ijbesl8 24 7 or or CC cord-313499-8ijbesl8 24 8 American american JJ cord-313499-8ijbesl8 24 9 trypanosomiasis trypanosomiasis NN cord-313499-8ijbesl8 24 10 , , , cord-313499-8ijbesl8 24 11 NAT NAT NNP cord-313499-8ijbesl8 24 12 is be VBZ cord-313499-8ijbesl8 24 13 most most RBS cord-313499-8ijbesl8 24 14 likely likely JJ cord-313499-8ijbesl8 24 15 to to TO cord-313499-8ijbesl8 24 16 be be VB cord-313499-8ijbesl8 24 17 informative informative JJ cord-313499-8ijbesl8 24 18 during during IN cord-313499-8ijbesl8 24 19 acute acute JJ cord-313499-8ijbesl8 24 20 disease disease NN cord-313499-8ijbesl8 24 21 while while IN cord-313499-8ijbesl8 24 22 serology serology NN cord-313499-8ijbesl8 24 23 is be VBZ cord-313499-8ijbesl8 24 24 helpful helpful JJ cord-313499-8ijbesl8 24 25 at at IN cord-313499-8ijbesl8 24 26 later later JJ cord-313499-8ijbesl8 24 27 stages stage NNS cord-313499-8ijbesl8 24 28 . . . cord-313499-8ijbesl8 25 1 In in IN cord-313499-8ijbesl8 25 2 the the DT cord-313499-8ijbesl8 25 3 case case NN cord-313499-8ijbesl8 25 4 of of IN cord-313499-8ijbesl8 25 5 the the DT cord-313499-8ijbesl8 25 6 2003 2003 CD cord-313499-8ijbesl8 25 7 - - SYM cord-313499-8ijbesl8 25 8 04 04 CD cord-313499-8ijbesl8 25 9 SARS SARS NNP cord-313499-8ijbesl8 25 10 - - HYPH cord-313499-8ijbesl8 25 11 CoV CoV NNP cord-313499-8ijbesl8 25 12 outbreak outbreak NN cord-313499-8ijbesl8 25 13 , , , cord-313499-8ijbesl8 25 14 serology serology NN cord-313499-8ijbesl8 25 15 was be VBD cord-313499-8ijbesl8 25 16 primarily primarily RB cord-313499-8ijbesl8 25 17 an an DT cord-313499-8ijbesl8 25 18 epidemiological epidemiological JJ cord-313499-8ijbesl8 25 19 tool tool NN cord-313499-8ijbesl8 25 20 that that WDT cord-313499-8ijbesl8 25 21 could could MD cord-313499-8ijbesl8 25 22 help help VB cord-313499-8ijbesl8 25 23 determine determine VB cord-313499-8ijbesl8 25 24 the the DT cord-313499-8ijbesl8 25 25 number number NN cord-313499-8ijbesl8 25 26 of of IN cord-313499-8ijbesl8 25 27 silent silent JJ cord-313499-8ijbesl8 25 28 infections infection NNS cord-313499-8ijbesl8 25 29 , , , cord-313499-8ijbesl8 25 30 how how WRB cord-313499-8ijbesl8 25 31 the the DT cord-313499-8ijbesl8 25 32 disease disease NN cord-313499-8ijbesl8 25 33 progressed progress VBD cord-313499-8ijbesl8 25 34 , , , cord-313499-8ijbesl8 25 35 defining define VBG cord-313499-8ijbesl8 25 36 transmission transmission NN cord-313499-8ijbesl8 25 37 patterns pattern NNS cord-313499-8ijbesl8 25 38 , , , cord-313499-8ijbesl8 25 39 and and CC cord-313499-8ijbesl8 25 40 the the DT cord-313499-8ijbesl8 25 41 possible possible JJ cord-313499-8ijbesl8 25 42 origin origin NN cord-313499-8ijbesl8 25 43 of of IN cord-313499-8ijbesl8 25 44 the the DT cord-313499-8ijbesl8 25 45 virus virus NN cord-313499-8ijbesl8 25 46 itself -PRON- PRP cord-313499-8ijbesl8 25 47 2 2 CD cord-313499-8ijbesl8 25 48 . . . cord-313499-8ijbesl8 26 1 In in IN cord-313499-8ijbesl8 26 2 the the DT cord-313499-8ijbesl8 26 3 case case NN cord-313499-8ijbesl8 26 4 of of IN cord-313499-8ijbesl8 26 5 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 26 6 , , , cord-313499-8ijbesl8 26 7 while while IN cord-313499-8ijbesl8 26 8 serological serological JJ cord-313499-8ijbesl8 26 9 analysis analysis NN cord-313499-8ijbesl8 26 10 may may MD cord-313499-8ijbesl8 26 11 be be VB cord-313499-8ijbesl8 26 12 helpful helpful JJ cord-313499-8ijbesl8 26 13 in in IN cord-313499-8ijbesl8 26 14 examining examine VBG cord-313499-8ijbesl8 26 15 exposure exposure NN cord-313499-8ijbesl8 26 16 , , , cord-313499-8ijbesl8 26 17 such such JJ cord-313499-8ijbesl8 26 18 approaches approach NNS cord-313499-8ijbesl8 26 19 can can MD cord-313499-8ijbesl8 26 20 be be VB cord-313499-8ijbesl8 26 21 more more RBR cord-313499-8ijbesl8 26 22 challenging challenging JJ cord-313499-8ijbesl8 26 23 to to TO cord-313499-8ijbesl8 26 24 interpret interpret VB cord-313499-8ijbesl8 26 25 in in IN cord-313499-8ijbesl8 26 26 patients patient NNS cord-313499-8ijbesl8 26 27 with with IN cord-313499-8ijbesl8 26 28 acute acute JJ cord-313499-8ijbesl8 26 29 infection infection NN cord-313499-8ijbesl8 26 30 . . . cord-313499-8ijbesl8 27 1 Significant significant JJ cord-313499-8ijbesl8 27 2 variability variability NN cord-313499-8ijbesl8 27 3 in in IN cord-313499-8ijbesl8 27 4 the the DT cord-313499-8ijbesl8 27 5 kinetics kinetic NNS cord-313499-8ijbesl8 27 6 and and CC cord-313499-8ijbesl8 27 7 magnitude magnitude NN cord-313499-8ijbesl8 27 8 of of IN cord-313499-8ijbesl8 27 9 the the DT cord-313499-8ijbesl8 27 10 serological serological JJ cord-313499-8ijbesl8 27 11 response response NN cord-313499-8ijbesl8 27 12 , , , cord-313499-8ijbesl8 27 13 especially especially RB cord-313499-8ijbesl8 27 14 early early RB cord-313499-8ijbesl8 27 15 in in IN cord-313499-8ijbesl8 27 16 infection infection NN cord-313499-8ijbesl8 27 17 , , , cord-313499-8ijbesl8 27 18 could could MD cord-313499-8ijbesl8 27 19 contribute contribute VB cord-313499-8ijbesl8 27 20 to to IN cord-313499-8ijbesl8 27 21 false false JJ cord-313499-8ijbesl8 27 22 negative negative JJ cord-313499-8ijbesl8 27 23 results result NNS cord-313499-8ijbesl8 27 24 . . . cord-313499-8ijbesl8 28 1 In in IN cord-313499-8ijbesl8 28 2 addition addition NN cord-313499-8ijbesl8 28 3 , , , cord-313499-8ijbesl8 28 4 while while IN cord-313499-8ijbesl8 28 5 both both CC cord-313499-8ijbesl8 28 6 NAT NAT NNP cord-313499-8ijbesl8 28 7 and and CC cord-313499-8ijbesl8 28 8 serological serological JJ cord-313499-8ijbesl8 28 9 assays assay NNS cord-313499-8ijbesl8 28 10 can can MD cord-313499-8ijbesl8 28 11 suffer suffer VB cord-313499-8ijbesl8 28 12 from from IN cord-313499-8ijbesl8 28 13 inadequate inadequate JJ cord-313499-8ijbesl8 28 14 analytical analytical JJ cord-313499-8ijbesl8 28 15 sensitivity sensitivity NN cord-313499-8ijbesl8 28 16 , , , cord-313499-8ijbesl8 28 17 a a DT cord-313499-8ijbesl8 28 18 broader broad JJR cord-313499-8ijbesl8 28 19 range range NN cord-313499-8ijbesl8 28 20 of of IN cord-313499-8ijbesl8 28 21 factors factor NNS cord-313499-8ijbesl8 28 22 can can MD cord-313499-8ijbesl8 28 23 influence influence VB cord-313499-8ijbesl8 28 24 the the DT cord-313499-8ijbesl8 28 25 sensitivity sensitivity NN cord-313499-8ijbesl8 28 26 and and CC cord-313499-8ijbesl8 28 27 specificity specificity NN cord-313499-8ijbesl8 28 28 of of IN cord-313499-8ijbesl8 28 29 serological serological JJ cord-313499-8ijbesl8 28 30 tests test NNS cord-313499-8ijbesl8 28 31 , , , cord-313499-8ijbesl8 28 32 including include VBG cord-313499-8ijbesl8 28 33 a a DT cord-313499-8ijbesl8 28 34 variety variety NN cord-313499-8ijbesl8 28 35 of of IN cord-313499-8ijbesl8 28 36 platform platform NN cord-313499-8ijbesl8 28 37 design design NN cord-313499-8ijbesl8 28 38 considerations consideration NNS cord-313499-8ijbesl8 28 39 such such JJ cord-313499-8ijbesl8 28 40 as as IN cord-313499-8ijbesl8 28 41 the the DT cord-313499-8ijbesl8 28 42 antigen antigen NN cord-313499-8ijbesl8 28 43 coating coating NN cord-313499-8ijbesl8 28 44 density density NN cord-313499-8ijbesl8 28 45 , , , cord-313499-8ijbesl8 28 46 dilution dilution NN cord-313499-8ijbesl8 28 47 matrix matrix NN cord-313499-8ijbesl8 28 48 considerations consideration NNS cord-313499-8ijbesl8 28 49 and and CC cord-313499-8ijbesl8 28 50 the the DT cord-313499-8ijbesl8 28 51 actual actual JJ cord-313499-8ijbesl8 28 52 serum serum NN cord-313499-8ijbesl8 28 53 dilution dilution NN cord-313499-8ijbesl8 28 54 employed employ VBN cord-313499-8ijbesl8 28 55 . . . cord-313499-8ijbesl8 29 1 Challenges challenge NNS cord-313499-8ijbesl8 29 2 with with IN cord-313499-8ijbesl8 29 3 false false JJ cord-313499-8ijbesl8 29 4 positives positive NNS cord-313499-8ijbesl8 29 5 can can MD cord-313499-8ijbesl8 29 6 also also RB cord-313499-8ijbesl8 29 7 limit limit VB cord-313499-8ijbesl8 29 8 the the DT cord-313499-8ijbesl8 29 9 value value NN cord-313499-8ijbesl8 29 10 of of IN cord-313499-8ijbesl8 29 11 serological serological JJ cord-313499-8ijbesl8 29 12 tests test NNS cord-313499-8ijbesl8 29 13 . . . cord-313499-8ijbesl8 30 1 Cross cross NN cord-313499-8ijbesl8 30 2 - - NN cord-313499-8ijbesl8 30 3 reactivity reactivity NN cord-313499-8ijbesl8 30 4 with with IN cord-313499-8ijbesl8 30 5 other other JJ cord-313499-8ijbesl8 30 6 strains strain NNS cord-313499-8ijbesl8 30 7 of of IN cord-313499-8ijbesl8 30 8 coronavirus coronavirus NN cord-313499-8ijbesl8 30 9 2 2 CD cord-313499-8ijbesl8 30 10 , , , cord-313499-8ijbesl8 30 11 in in IN cord-313499-8ijbesl8 30 12 addition addition NN cord-313499-8ijbesl8 30 13 to to IN cord-313499-8ijbesl8 30 14 other other JJ cord-313499-8ijbesl8 30 15 pathogens pathogen NNS cord-313499-8ijbesl8 30 16 altogether altogether RB cord-313499-8ijbesl8 30 17 , , , cord-313499-8ijbesl8 30 18 can can MD cord-313499-8ijbesl8 30 19 limit limit VB cord-313499-8ijbesl8 30 20 their -PRON- PRP$ cord-313499-8ijbesl8 30 21 accuracy accuracy NN cord-313499-8ijbesl8 30 22 . . . cord-313499-8ijbesl8 31 1 Consistent consistent JJ cord-313499-8ijbesl8 31 2 with with IN cord-313499-8ijbesl8 31 3 this this DT cord-313499-8ijbesl8 31 4 , , , cord-313499-8ijbesl8 31 5 during during IN cord-313499-8ijbesl8 31 6 the the DT cord-313499-8ijbesl8 31 7 2003 2003 CD cord-313499-8ijbesl8 31 8 - - SYM cord-313499-8ijbesl8 31 9 04 04 CD cord-313499-8ijbesl8 31 10 SARS SARS NNP cord-313499-8ijbesl8 31 11 - - HYPH cord-313499-8ijbesl8 31 12 CoV CoV NNP cord-313499-8ijbesl8 31 13 outbreak outbreak NN cord-313499-8ijbesl8 31 14 , , , cord-313499-8ijbesl8 31 15 various various JJ cord-313499-8ijbesl8 31 16 serological serological JJ cord-313499-8ijbesl8 31 17 assays assay NNS cord-313499-8ijbesl8 31 18 demonstrated demonstrate VBD cord-313499-8ijbesl8 31 19 cross cross NN cord-313499-8ijbesl8 31 20 - - NN cord-313499-8ijbesl8 31 21 reactivity reactivity NN cord-313499-8ijbesl8 31 22 in in IN cord-313499-8ijbesl8 31 23 assays assay NNS cord-313499-8ijbesl8 31 24 that that WDT cord-313499-8ijbesl8 31 25 used use VBD cord-313499-8ijbesl8 31 26 whole whole JJ cord-313499-8ijbesl8 31 27 virus virus NN cord-313499-8ijbesl8 31 28 in in IN cord-313499-8ijbesl8 31 29 addition addition NN cord-313499-8ijbesl8 31 30 to to IN cord-313499-8ijbesl8 31 31 the the DT cord-313499-8ijbesl8 31 32 N n CD cord-313499-8ijbesl8 31 33 protein protein NN cord-313499-8ijbesl8 31 34 . . . cord-313499-8ijbesl8 32 1 As as IN cord-313499-8ijbesl8 32 2 a a DT cord-313499-8ijbesl8 32 3 result result NN cord-313499-8ijbesl8 32 4 , , , cord-313499-8ijbesl8 32 5 false false JJ cord-313499-8ijbesl8 32 6 positive positive JJ cord-313499-8ijbesl8 32 7 serological serological JJ cord-313499-8ijbesl8 32 8 results result NNS cord-313499-8ijbesl8 32 9 , , , cord-313499-8ijbesl8 32 10 which which WDT cord-313499-8ijbesl8 32 11 can can MD cord-313499-8ijbesl8 32 12 be be VB cord-313499-8ijbesl8 32 13 particularly particularly RB cord-313499-8ijbesl8 32 14 challenging challenging JJ cord-313499-8ijbesl8 32 15 with with IN cord-313499-8ijbesl8 32 16 IgM IgM NNP cord-313499-8ijbesl8 32 17 antibodies antibody NNS cord-313499-8ijbesl8 32 18 , , , cord-313499-8ijbesl8 32 19 can can MD cord-313499-8ijbesl8 32 20 make make VB cord-313499-8ijbesl8 32 21 it -PRON- PRP cord-313499-8ijbesl8 32 22 difficult difficult JJ cord-313499-8ijbesl8 32 23 to to TO cord-313499-8ijbesl8 32 24 accurately accurately RB cord-313499-8ijbesl8 32 25 interpret interpret VB cord-313499-8ijbesl8 32 26 findings finding NNS cord-313499-8ijbesl8 32 27 . . . cord-313499-8ijbesl8 33 1 Despite despite IN cord-313499-8ijbesl8 33 2 these these DT cord-313499-8ijbesl8 33 3 considerations consideration NNS cord-313499-8ijbesl8 33 4 , , , cord-313499-8ijbesl8 33 5 the the DT cord-313499-8ijbesl8 33 6 results result NNS cord-313499-8ijbesl8 33 7 of of IN cord-313499-8ijbesl8 33 8 this this DT cord-313499-8ijbesl8 33 9 manuscript manuscript NN cord-313499-8ijbesl8 33 10 suggest suggest VBP cord-313499-8ijbesl8 33 11 repeat repeat VB cord-313499-8ijbesl8 33 12 serological serological JJ cord-313499-8ijbesl8 33 13 testing testing NN cord-313499-8ijbesl8 33 14 may may MD cord-313499-8ijbesl8 33 15 be be VB cord-313499-8ijbesl8 33 16 informative informative JJ cord-313499-8ijbesl8 33 17 in in IN cord-313499-8ijbesl8 33 18 the the DT cord-313499-8ijbesl8 33 19 acute acute JJ cord-313499-8ijbesl8 33 20 setting setting NN cord-313499-8ijbesl8 33 21 , , , cord-313499-8ijbesl8 33 22 especially especially RB cord-313499-8ijbesl8 33 23 in in IN cord-313499-8ijbesl8 33 24 patients patient NNS cord-313499-8ijbesl8 33 25 who who WP cord-313499-8ijbesl8 33 26 continue continue VBP cord-313499-8ijbesl8 33 27 to to TO cord-313499-8ijbesl8 33 28 follow follow VB cord-313499-8ijbesl8 33 29 a a DT cord-313499-8ijbesl8 33 30 COVID-19-like COVID-19-like NNP cord-313499-8ijbesl8 33 31 disease disease NN cord-313499-8ijbesl8 33 32 course course NN cord-313499-8ijbesl8 33 33 despite despite IN cord-313499-8ijbesl8 33 34 NAT NAT NNP cord-313499-8ijbesl8 33 35 negativity negativity NN cord-313499-8ijbesl8 33 36 . . . cord-313499-8ijbesl8 34 1 The the DT cord-313499-8ijbesl8 34 2 blood blood NN cord-313499-8ijbesl8 34 3 donation donation NN cord-313499-8ijbesl8 34 4 industry industry NN cord-313499-8ijbesl8 34 5 has have VBZ cord-313499-8ijbesl8 34 6 used use VBN cord-313499-8ijbesl8 34 7 the the DT cord-313499-8ijbesl8 34 8 approach approach NN cord-313499-8ijbesl8 34 9 of of IN cord-313499-8ijbesl8 34 10 coupling couple VBG cord-313499-8ijbesl8 34 11 the the DT cord-313499-8ijbesl8 34 12 potential potential JJ cord-313499-8ijbesl8 34 13 limitations limitation NNS cord-313499-8ijbesl8 34 14 and and CC cord-313499-8ijbesl8 34 15 strengths strength NNS cord-313499-8ijbesl8 34 16 of of IN cord-313499-8ijbesl8 34 17 NAT NAT NNP cord-313499-8ijbesl8 34 18 and and CC cord-313499-8ijbesl8 34 19 serological serological JJ cord-313499-8ijbesl8 34 20 assays assay NNS cord-313499-8ijbesl8 34 21 to to TO cord-313499-8ijbesl8 34 22 detect detect VB cord-313499-8ijbesl8 34 23 pathogens pathogen NNS cord-313499-8ijbesl8 34 24 in in IN cord-313499-8ijbesl8 34 25 blood blood NN cord-313499-8ijbesl8 34 26 . . . cord-313499-8ijbesl8 35 1 A a DT cord-313499-8ijbesl8 35 2 similar similar JJ cord-313499-8ijbesl8 35 3 approach approach NN cord-313499-8ijbesl8 35 4 could could MD cord-313499-8ijbesl8 35 5 increase increase VB cord-313499-8ijbesl8 35 6 the the DT cord-313499-8ijbesl8 35 7 overall overall JJ cord-313499-8ijbesl8 35 8 likelihood likelihood NN cord-313499-8ijbesl8 35 9 of of IN cord-313499-8ijbesl8 35 10 identifying identify VBG cord-313499-8ijbesl8 35 11 COVID-19 COVID-19 , cord-313499-8ijbesl8 35 12 infected infected JJ cord-313499-8ijbesl8 35 13 patients patient NNS cord-313499-8ijbesl8 35 14 as as IN cord-313499-8ijbesl8 35 15 shown show VBN cord-313499-8ijbesl8 35 16 by by IN cord-313499-8ijbesl8 35 17 F F NNP cord-313499-8ijbesl8 35 18 Xiang Xiang NNP cord-313499-8ijbesl8 35 19 et et NNP cord-313499-8ijbesl8 35 20 al al NNP cord-313499-8ijbesl8 35 21 1 1 CD cord-313499-8ijbesl8 35 22 . . . cord-313499-8ijbesl8 36 1 While while IN cord-313499-8ijbesl8 36 2 the the DT cord-313499-8ijbesl8 36 3 results result NNS cord-313499-8ijbesl8 36 4 presented present VBN cord-313499-8ijbesl8 36 5 in in IN cord-313499-8ijbesl8 36 6 this this DT cord-313499-8ijbesl8 36 7 study study NN cord-313499-8ijbesl8 36 8 provide provide VBP cord-313499-8ijbesl8 36 9 some some DT cord-313499-8ijbesl8 36 10 insight insight NN cord-313499-8ijbesl8 36 11 into into IN cord-313499-8ijbesl8 36 12 how how WRB cord-313499-8ijbesl8 36 13 to to TO cord-313499-8ijbesl8 36 14 possibly possibly RB cord-313499-8ijbesl8 36 15 incorporate incorporate VB cord-313499-8ijbesl8 36 16 serological serological JJ cord-313499-8ijbesl8 36 17 testing testing NN cord-313499-8ijbesl8 36 18 into into IN cord-313499-8ijbesl8 36 19 the the DT cord-313499-8ijbesl8 36 20 workup workup NN cord-313499-8ijbesl8 36 21 of of IN cord-313499-8ijbesl8 36 22 acutely acutely RB cord-313499-8ijbesl8 36 23 ill ill JJ cord-313499-8ijbesl8 36 24 patients patient NNS cord-313499-8ijbesl8 36 25 , , , cord-313499-8ijbesl8 36 26 especially especially RB cord-313499-8ijbesl8 36 27 if if IN cord-313499-8ijbesl8 36 28 NAT NAT NNP cord-313499-8ijbesl8 36 29 test test NN cord-313499-8ijbesl8 36 30 results result NNS cord-313499-8ijbesl8 36 31 are be VBP cord-313499-8ijbesl8 36 32 negative negative JJ cord-313499-8ijbesl8 36 33 , , , cord-313499-8ijbesl8 36 34 how how WRB cord-313499-8ijbesl8 36 35 serology serology NN cord-313499-8ijbesl8 36 36 will will MD cord-313499-8ijbesl8 36 37 be be VB cord-313499-8ijbesl8 36 38 employed employ VBN cord-313499-8ijbesl8 36 39 in in IN cord-313499-8ijbesl8 36 40 screening screen VBG cord-313499-8ijbesl8 36 41 asymptomatic asymptomatic JJ cord-313499-8ijbesl8 36 42 individuals individual NNS cord-313499-8ijbesl8 36 43 or or CC cord-313499-8ijbesl8 36 44 patients patient NNS cord-313499-8ijbesl8 36 45 who who WP cord-313499-8ijbesl8 36 46 never never RB cord-313499-8ijbesl8 36 47 underwent undergo VBD cord-313499-8ijbesl8 36 48 NAT NAT NNP cord-313499-8ijbesl8 36 49 testing testing NN cord-313499-8ijbesl8 36 50 during during IN cord-313499-8ijbesl8 36 51 acute acute JJ cord-313499-8ijbesl8 36 52 infection infection NN cord-313499-8ijbesl8 36 53 still still RB cord-313499-8ijbesl8 36 54 remains remain VBZ cord-313499-8ijbesl8 36 55 unclear unclear JJ cord-313499-8ijbesl8 36 56 . . . cord-313499-8ijbesl8 37 1 For for IN cord-313499-8ijbesl8 37 2 example example NN cord-313499-8ijbesl8 37 3 , , , cord-313499-8ijbesl8 37 4 if if IN cord-313499-8ijbesl8 37 5 someone someone NN cord-313499-8ijbesl8 37 6 is be VBZ cord-313499-8ijbesl8 37 7 found find VBN cord-313499-8ijbesl8 37 8 to to TO cord-313499-8ijbesl8 37 9 be be VB cord-313499-8ijbesl8 37 10 serologically serologically RB cord-313499-8ijbesl8 37 11 positive positive JJ cord-313499-8ijbesl8 37 12 , , , cord-313499-8ijbesl8 37 13 should should MD cord-313499-8ijbesl8 37 14 a a DT cord-313499-8ijbesl8 37 15 follow follow VB cord-313499-8ijbesl8 37 16 up up RP cord-313499-8ijbesl8 37 17 NAT NAT NNP cord-313499-8ijbesl8 37 18 test test NN cord-313499-8ijbesl8 37 19 be be VB cord-313499-8ijbesl8 37 20 performed perform VBN cord-313499-8ijbesl8 37 21 to to TO cord-313499-8ijbesl8 37 22 determine determine VB cord-313499-8ijbesl8 37 23 if if IN cord-313499-8ijbesl8 37 24 the the DT cord-313499-8ijbesl8 37 25 individual individual NN cord-313499-8ijbesl8 37 26 is be VBZ cord-313499-8ijbesl8 37 27 shedding shed VBG cord-313499-8ijbesl8 37 28 virus virus NN cord-313499-8ijbesl8 37 29 ? ? . cord-313499-8ijbesl8 38 1 Furthermore furthermore RB cord-313499-8ijbesl8 38 2 , , , cord-313499-8ijbesl8 38 3 the the DT cord-313499-8ijbesl8 38 4 extent extent NN cord-313499-8ijbesl8 38 5 to to TO cord-313499-8ijbesl8 38 6 which which WDT cord-313499-8ijbesl8 38 7 COVID-19 covid-19 NN cord-313499-8ijbesl8 38 8 seroreactivity seroreactivity NN cord-313499-8ijbesl8 38 9 reflects reflect VBZ cord-313499-8ijbesl8 38 10 actual actual JJ cord-313499-8ijbesl8 38 11 immunity immunity NN cord-313499-8ijbesl8 38 12 also also RB cord-313499-8ijbesl8 38 13 represents represent VBZ cord-313499-8ijbesl8 38 14 an an DT cord-313499-8ijbesl8 38 15 outstanding outstanding JJ cord-313499-8ijbesl8 38 16 question question NN cord-313499-8ijbesl8 38 17 . . . cord-313499-8ijbesl8 39 1 While while IN cord-313499-8ijbesl8 39 2 established establish VBN cord-313499-8ijbesl8 39 3 seroreactive seroreactive JJ cord-313499-8ijbesl8 39 4 corollaries corollary NNS cord-313499-8ijbesl8 39 5 with with IN cord-313499-8ijbesl8 39 6 actual actual JJ cord-313499-8ijbesl8 39 7 immunity immunity NN cord-313499-8ijbesl8 39 8 exist exist VBP cord-313499-8ijbesl8 39 9 , , , cord-313499-8ijbesl8 39 10 such such JJ cord-313499-8ijbesl8 39 11 as as IN cord-313499-8ijbesl8 39 12 antibodies antibody NNS cord-313499-8ijbesl8 39 13 against against IN cord-313499-8ijbesl8 39 14 hepatitis hepatitis NNP cord-313499-8ijbesl8 39 15 B B NNP cord-313499-8ijbesl8 39 16 surface surface NN cord-313499-8ijbesl8 39 17 antigen antigen NN cord-313499-8ijbesl8 39 18 , , , cord-313499-8ijbesl8 39 19 these these DT cord-313499-8ijbesl8 39 20 were be VBD cord-313499-8ijbesl8 39 21 developed develop VBN cord-313499-8ijbesl8 39 22 over over IN cord-313499-8ijbesl8 39 23 long long JJ cord-313499-8ijbesl8 39 24 periods period NNS cord-313499-8ijbesl8 39 25 of of IN cord-313499-8ijbesl8 39 26 time time NN cord-313499-8ijbesl8 39 27 . . . cord-313499-8ijbesl8 40 1 Furthermore furthermore RB cord-313499-8ijbesl8 40 2 , , , cord-313499-8ijbesl8 40 3 which which WDT cord-313499-8ijbesl8 40 4 populations population NNS cord-313499-8ijbesl8 40 5 would would MD cord-313499-8ijbesl8 40 6 most most RBS cord-313499-8ijbesl8 40 7 benefit benefit VB cord-313499-8ijbesl8 40 8 from from IN cord-313499-8ijbesl8 40 9 COVID-19 covid-19 JJ cord-313499-8ijbesl8 40 10 serological serological JJ cord-313499-8ijbesl8 40 11 testing testing NN cord-313499-8ijbesl8 40 12 remains remain VBZ cord-313499-8ijbesl8 40 13 unknown unknown JJ cord-313499-8ijbesl8 40 14 . . . cord-313499-8ijbesl8 41 1 Several several JJ cord-313499-8ijbesl8 41 2 populations population NNS cord-313499-8ijbesl8 41 3 may may MD cord-313499-8ijbesl8 41 4 be be VB cord-313499-8ijbesl8 41 5 good good JJ cord-313499-8ijbesl8 41 6 candidates candidate NNS cord-313499-8ijbesl8 41 7 : : : cord-313499-8ijbesl8 41 8 1 1 CD cord-313499-8ijbesl8 41 9 . . . cord-313499-8ijbesl8 42 1 Patients patient NNS cord-313499-8ijbesl8 42 2 that that WDT cord-313499-8ijbesl8 42 3 have have VBP cord-313499-8ijbesl8 42 4 had have VBN cord-313499-8ijbesl8 42 5 COVID-19 COVID-19 VBN cord-313499-8ijbesl8 42 6 compatible compatible JJ cord-313499-8ijbesl8 42 7 symptoms symptom NNS cord-313499-8ijbesl8 42 8 but but CC cord-313499-8ijbesl8 42 9 have have VBP cord-313499-8ijbesl8 42 10 been be VBN cord-313499-8ijbesl8 42 11 NAT NAT NNP cord-313499-8ijbesl8 42 12 negative negative JJ cord-313499-8ijbesl8 42 13 ( ( -LRB- cord-313499-8ijbesl8 42 14 as as IN cord-313499-8ijbesl8 42 15 outlined outline VBN cord-313499-8ijbesl8 42 16 in in IN cord-313499-8ijbesl8 42 17 the the DT cord-313499-8ijbesl8 42 18 present present JJ cord-313499-8ijbesl8 42 19 study study NN cord-313499-8ijbesl8 42 20 1 1 CD cord-313499-8ijbesl8 42 21 ) ) -RRB- cord-313499-8ijbesl8 42 22 . . . cord-313499-8ijbesl8 43 1 2 2 LS cord-313499-8ijbesl8 43 2 . . . cord-313499-8ijbesl8 44 1 Populations population NNS cord-313499-8ijbesl8 44 2 in in IN cord-313499-8ijbesl8 44 3 general general JJ cord-313499-8ijbesl8 44 4 to to TO cord-313499-8ijbesl8 44 5 define define VB cord-313499-8ijbesl8 44 6 the the DT cord-313499-8ijbesl8 44 7 degree degree NN cord-313499-8ijbesl8 44 8 of of IN cord-313499-8ijbesl8 44 9 community community NN cord-313499-8ijbesl8 44 10 exposure exposure NN cord-313499-8ijbesl8 44 11 which which WDT cord-313499-8ijbesl8 44 12 may may MD cord-313499-8ijbesl8 44 13 help help VB cord-313499-8ijbesl8 44 14 define define VB cord-313499-8ijbesl8 44 15 the the DT cord-313499-8ijbesl8 44 16 R r NN cord-313499-8ijbesl8 44 17 null null NN cord-313499-8ijbesl8 44 18 and and CC cord-313499-8ijbesl8 44 19 mortality mortality NN cord-313499-8ijbesl8 44 20 rate rate NN cord-313499-8ijbesl8 44 21 . . . cord-313499-8ijbesl8 45 1 3 3 LS cord-313499-8ijbesl8 45 2 . . . cord-313499-8ijbesl8 46 1 Frontline frontline JJ cord-313499-8ijbesl8 46 2 healthcare healthcare NN cord-313499-8ijbesl8 46 3 workers worker NNS cord-313499-8ijbesl8 46 4 to to TO cord-313499-8ijbesl8 46 5 likewise likewise RB cord-313499-8ijbesl8 46 6 define define VB cord-313499-8ijbesl8 46 7 exposure exposure NN cord-313499-8ijbesl8 46 8 . . . cord-313499-8ijbesl8 47 1 Additional additional JJ cord-313499-8ijbesl8 47 2 testing testing NN cord-313499-8ijbesl8 47 3 , , , cord-313499-8ijbesl8 47 4 such such JJ cord-313499-8ijbesl8 47 5 as as IN cord-313499-8ijbesl8 47 6 NAT NAT NNP cord-313499-8ijbesl8 47 7 testing testing NN cord-313499-8ijbesl8 47 8 , , , cord-313499-8ijbesl8 47 9 may may MD cord-313499-8ijbesl8 47 10 be be VB cord-313499-8ijbesl8 47 11 warranted warrant VBN cord-313499-8ijbesl8 47 12 in in IN cord-313499-8ijbesl8 47 13 serological serological JJ cord-313499-8ijbesl8 47 14 positive positive JJ cord-313499-8ijbesl8 47 15 individuals individual NNS cord-313499-8ijbesl8 47 16 to to TO cord-313499-8ijbesl8 47 17 determine determine VB cord-313499-8ijbesl8 47 18 potential potential JJ cord-313499-8ijbesl8 47 19 risk risk NN cord-313499-8ijbesl8 47 20 for for IN cord-313499-8ijbesl8 47 21 infecting infect VBG cord-313499-8ijbesl8 47 22 others other NNS cord-313499-8ijbesl8 47 23 . . . cord-313499-8ijbesl8 48 1 It -PRON- PRP cord-313499-8ijbesl8 48 2 is be VBZ cord-313499-8ijbesl8 48 3 important important JJ cord-313499-8ijbesl8 48 4 to to TO cord-313499-8ijbesl8 48 5 reiterate reiterate VB cord-313499-8ijbesl8 48 6 that that IN cord-313499-8ijbesl8 48 7 it -PRON- PRP cord-313499-8ijbesl8 48 8 is be VBZ cord-313499-8ijbesl8 48 9 unknown unknown JJ cord-313499-8ijbesl8 48 10 the the DT cord-313499-8ijbesl8 48 11 extent extent NN cord-313499-8ijbesl8 48 12 to to TO cord-313499-8ijbesl8 48 13 which which WDT cord-313499-8ijbesl8 48 14 antibody antibody NN cord-313499-8ijbesl8 48 15 positivity positivity NN cord-313499-8ijbesl8 48 16 translates translate VBZ cord-313499-8ijbesl8 48 17 to to IN cord-313499-8ijbesl8 48 18 actual actual JJ cord-313499-8ijbesl8 48 19 immunity immunity NN cord-313499-8ijbesl8 48 20 . . . cord-313499-8ijbesl8 49 1 4 4 LS cord-313499-8ijbesl8 49 2 . . . cord-313499-8ijbesl8 50 1 Convalescent convalescent JJ cord-313499-8ijbesl8 50 2 patients patient NNS cord-313499-8ijbesl8 50 3 that that WDT cord-313499-8ijbesl8 50 4 want want VBP cord-313499-8ijbesl8 50 5 to to TO cord-313499-8ijbesl8 50 6 donate donate VB cord-313499-8ijbesl8 50 7 plasma plasma NN cord-313499-8ijbesl8 50 8 for for IN cord-313499-8ijbesl8 50 9 patients patient NNS cord-313499-8ijbesl8 50 10 suffering suffer VBG cord-313499-8ijbesl8 50 11 from from IN cord-313499-8ijbesl8 50 12 infection infection NN cord-313499-8ijbesl8 50 13 . . . cord-313499-8ijbesl8 51 1 Further further JJ cord-313499-8ijbesl8 51 2 testing testing NN cord-313499-8ijbesl8 51 3 to to TO cord-313499-8ijbesl8 51 4 define define VB cord-313499-8ijbesl8 51 5 optimal optimal JJ cord-313499-8ijbesl8 51 6 titer titer NN cord-313499-8ijbesl8 51 7 and and CC cord-313499-8ijbesl8 51 8 overall overall JJ cord-313499-8ijbesl8 51 9 neutralizing neutralize VBG cord-313499-8ijbesl8 51 10 activity activity NN cord-313499-8ijbesl8 51 11 will will MD cord-313499-8ijbesl8 51 12 be be VB cord-313499-8ijbesl8 51 13 needed need VBN cord-313499-8ijbesl8 51 14 . . . cord-313499-8ijbesl8 52 1 In in IN cord-313499-8ijbesl8 52 2 short short JJ cord-313499-8ijbesl8 52 3 , , , cord-313499-8ijbesl8 52 4 the the DT cord-313499-8ijbesl8 52 5 article article NN cord-313499-8ijbesl8 52 6 of of IN cord-313499-8ijbesl8 52 7 F F NNP cord-313499-8ijbesl8 52 8 Xiang Xiang NNP cord-313499-8ijbesl8 52 9 et et NNP cord-313499-8ijbesl8 52 10 al al NNP cord-313499-8ijbesl8 52 11 . . NNP cord-313499-8ijbesl8 52 12 is be VBZ cord-313499-8ijbesl8 52 13 a a DT cord-313499-8ijbesl8 52 14 first first JJ cord-313499-8ijbesl8 52 15 step step NN cord-313499-8ijbesl8 52 16 to to TO cord-313499-8ijbesl8 52 17 better better RB cord-313499-8ijbesl8 52 18 understand understand VB cord-313499-8ijbesl8 52 19 the the DT cord-313499-8ijbesl8 52 20 antibody antibody NN cord-313499-8ijbesl8 52 21 response response NN cord-313499-8ijbesl8 52 22 against against IN cord-313499-8ijbesl8 52 23 SARS SARS NNP cord-313499-8ijbesl8 52 24 - - HYPH cord-313499-8ijbesl8 52 25 CoV-2 CoV-2 NNP cord-313499-8ijbesl8 52 26 and and CC cord-313499-8ijbesl8 52 27 in in IN cord-313499-8ijbesl8 52 28 so so RB cord-313499-8ijbesl8 52 29 doing do VBG cord-313499-8ijbesl8 52 30 provides provide VBZ cord-313499-8ijbesl8 52 31 important important JJ cord-313499-8ijbesl8 52 32 insight insight NN cord-313499-8ijbesl8 52 33 into into IN cord-313499-8ijbesl8 52 34 the the DT cord-313499-8ijbesl8 52 35 possible possible JJ cord-313499-8ijbesl8 52 36 characteristics characteristic NNS cord-313499-8ijbesl8 52 37 and and CC cord-313499-8ijbesl8 52 38 use use NN cord-313499-8ijbesl8 52 39 of of IN cord-313499-8ijbesl8 52 40 serological serological JJ cord-313499-8ijbesl8 52 41 tests test NNS cord-313499-8ijbesl8 52 42 in in IN cord-313499-8ijbesl8 52 43 this this DT cord-313499-8ijbesl8 52 44 ongoing ongoing JJ cord-313499-8ijbesl8 52 45 pandemic pandemic NN cord-313499-8ijbesl8 52 46 . . . cord-313499-8ijbesl8 53 1 However however RB cord-313499-8ijbesl8 53 2 , , , cord-313499-8ijbesl8 53 3 as as IN cord-313499-8ijbesl8 53 4 other other JJ cord-313499-8ijbesl8 53 5 serological serological JJ cord-313499-8ijbesl8 53 6 tests test NNS cord-313499-8ijbesl8 53 7 are be VBP cord-313499-8ijbesl8 53 8 developed develop VBN cord-313499-8ijbesl8 53 9 , , , cord-313499-8ijbesl8 53 10 the the DT cord-313499-8ijbesl8 53 11 analytical analytical JJ cord-313499-8ijbesl8 53 12 parameters parameter NNS cord-313499-8ijbesl8 53 13 of of IN cord-313499-8ijbesl8 53 14 each each DT cord-313499-8ijbesl8 53 15 of of IN cord-313499-8ijbesl8 53 16 these these DT cord-313499-8ijbesl8 53 17 tests test NNS cord-313499-8ijbesl8 53 18 will will MD cord-313499-8ijbesl8 53 19 likely likely RB cord-313499-8ijbesl8 53 20 differ differ VB cord-313499-8ijbesl8 53 21 , , , cord-313499-8ijbesl8 53 22 making make VBG cord-313499-8ijbesl8 53 23 it -PRON- PRP cord-313499-8ijbesl8 53 24 difficult difficult JJ cord-313499-8ijbesl8 53 25 to to TO cord-313499-8ijbesl8 53 26 fully fully RB cord-313499-8ijbesl8 53 27 extrapolate extrapolate VB cord-313499-8ijbesl8 53 28 these these DT cord-313499-8ijbesl8 53 29 findings finding NNS cord-313499-8ijbesl8 53 30 to to IN cord-313499-8ijbesl8 53 31 additional additional JJ cord-313499-8ijbesl8 53 32 serological serological JJ cord-313499-8ijbesl8 53 33 tests test NNS cord-313499-8ijbesl8 53 34 as as IN cord-313499-8ijbesl8 53 35 they -PRON- PRP cord-313499-8ijbesl8 53 36 become become VBP cord-313499-8ijbesl8 53 37 available available JJ cord-313499-8ijbesl8 53 38 . . . cord-313499-8ijbesl8 54 1 Additional additional JJ cord-313499-8ijbesl8 54 2 studies study NNS cord-313499-8ijbesl8 54 3 will will MD cord-313499-8ijbesl8 54 4 therefore therefore RB cord-313499-8ijbesl8 54 5 be be VB cord-313499-8ijbesl8 54 6 needed need VBN cord-313499-8ijbesl8 54 7 to to TO cord-313499-8ijbesl8 54 8 fully fully RB cord-313499-8ijbesl8 54 9 characterize characterize VB cord-313499-8ijbesl8 54 10 serological serological JJ cord-313499-8ijbesl8 54 11 platforms platform NNS cord-313499-8ijbesl8 54 12 that that WDT cord-313499-8ijbesl8 54 13 are be VBP cord-313499-8ijbesl8 54 14 rapidly rapidly RB cord-313499-8ijbesl8 54 15 becoming become VBG cord-313499-8ijbesl8 54 16 available available JJ cord-313499-8ijbesl8 54 17 , , , cord-313499-8ijbesl8 54 18 both both CC cord-313499-8ijbesl8 54 19 with with IN cord-313499-8ijbesl8 54 20 respect respect NN cord-313499-8ijbesl8 54 21 to to IN cord-313499-8ijbesl8 54 22 their -PRON- PRP$ cord-313499-8ijbesl8 54 23 analytical analytical JJ cord-313499-8ijbesl8 54 24 parameters parameter NNS cord-313499-8ijbesl8 54 25 and and CC cord-313499-8ijbesl8 54 26 the the DT cord-313499-8ijbesl8 54 27 role role NN cord-313499-8ijbesl8 54 28 they -PRON- PRP cord-313499-8ijbesl8 54 29 may may MD cord-313499-8ijbesl8 54 30 play play VB cord-313499-8ijbesl8 54 31 in in IN cord-313499-8ijbesl8 54 32 diagnosing diagnose VBG cord-313499-8ijbesl8 54 33 and and CC cord-313499-8ijbesl8 54 34 screening screen VBG cord-313499-8ijbesl8 54 35 individuals individual NNS cord-313499-8ijbesl8 54 36 for for IN cord-313499-8ijbesl8 54 37 COVID-19 covid-19 NN cord-313499-8ijbesl8 54 38 . . . cord-313499-8ijbesl8 55 1 However however RB cord-313499-8ijbesl8 55 2 , , , cord-313499-8ijbesl8 55 3 regardless regardless RB cord-313499-8ijbesl8 55 4 of of IN cord-313499-8ijbesl8 55 5 these these DT cord-313499-8ijbesl8 55 6 considerations consideration NNS cord-313499-8ijbesl8 55 7 , , , cord-313499-8ijbesl8 55 8 this this DT cord-313499-8ijbesl8 55 9 study study NN cord-313499-8ijbesl8 55 10 provides provide VBZ cord-313499-8ijbesl8 55 11 important important JJ cord-313499-8ijbesl8 55 12 insight insight NN cord-313499-8ijbesl8 55 13 into into IN cord-313499-8ijbesl8 55 14 the the DT cord-313499-8ijbesl8 55 15 seroreactivity seroreactivity NN cord-313499-8ijbesl8 55 16 of of IN cord-313499-8ijbesl8 55 17 patients patient NNS cord-313499-8ijbesl8 55 18 with with IN cord-313499-8ijbesl8 55 19 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 55 20 in in IN cord-313499-8ijbesl8 55 21 general general JJ cord-313499-8ijbesl8 55 22 that that WDT cord-313499-8ijbesl8 55 23 will will MD cord-313499-8ijbesl8 55 24 surely surely RB cord-313499-8ijbesl8 55 25 guide guide VB cord-313499-8ijbesl8 55 26 additional additional JJ cord-313499-8ijbesl8 55 27 test test NN cord-313499-8ijbesl8 55 28 development development NN cord-313499-8ijbesl8 55 29 and and CC cord-313499-8ijbesl8 55 30 use use NN cord-313499-8ijbesl8 55 31 of of IN cord-313499-8ijbesl8 55 32 serological serological JJ cord-313499-8ijbesl8 55 33 testing testing NN cord-313499-8ijbesl8 55 34 moving move VBG cord-313499-8ijbesl8 55 35 forward forward RB cord-313499-8ijbesl8 55 36 . . . cord-313499-8ijbesl8 56 1 Neither neither DT cord-313499-8ijbesl8 56 2 author author NN cord-313499-8ijbesl8 56 3 has have VBZ cord-313499-8ijbesl8 56 4 any any DT cord-313499-8ijbesl8 56 5 potential potential JJ cord-313499-8ijbesl8 56 6 conflicts conflict NNS cord-313499-8ijbesl8 56 7 to to TO cord-313499-8ijbesl8 56 8 disclose disclose VB cord-313499-8ijbesl8 56 9 . . . cord-313499-8ijbesl8 57 1 Antibody antibody NN cord-313499-8ijbesl8 57 2 detection detection NN cord-313499-8ijbesl8 57 3 and and CC cord-313499-8ijbesl8 57 4 dynamic dynamic JJ cord-313499-8ijbesl8 57 5 characteristics characteristic NNS cord-313499-8ijbesl8 57 6 in in IN cord-313499-8ijbesl8 57 7 patients patient NNS cord-313499-8ijbesl8 57 8 with with IN cord-313499-8ijbesl8 57 9 COVID-19 COVID-19 NNP cord-313499-8ijbesl8 57 10 Serological serological JJ cord-313499-8ijbesl8 57 11 assays assay NNS cord-313499-8ijbesl8 57 12 for for IN cord-313499-8ijbesl8 57 13 emerging emerge VBG cord-313499-8ijbesl8 57 14 coronaviruses coronaviruse NNS cord-313499-8ijbesl8 57 15 : : : cord-313499-8ijbesl8 57 16 Challenges challenge NNS cord-313499-8ijbesl8 57 17 and and CC cord-313499-8ijbesl8 57 18 pitfalls pitfall NNS