id author title date pages extension mime words sentences flesch summary cache txt cord-267942-ykl2xy7y Stiers, Michiel Successful ventilation of two animals with a single ventilator: individualized shared ventilator setup in an in vivo model 2020-08-27 .txt text/plain 1016 61 51 We have developed a modified shared ventilator design that allows for individualization of tidal volumes and driving pressures, positive end-expiratory pressure (PEEP), and inspired oxygen fraction (FiO 2 ) [6] , which can thus substantially individualize the delivered breaths, removing the need of pairing (see Fig. 1 ). We have now successfully used this ventilator setup in an in vivo model in a pair of ventilated sheep with different lung compliance, further supporting the potential of this shared ventilator setup as a lifesaving intervention in a crisis setting. We demonstrated the potential to modulate delivered tidal volumes and pressures, PEEP and FiO 2 in a shared ventilator setup in this in vivo model. This setup has allowed to safely ventilate a pair of animals with different lung compliance with a single ventilator, while monitoring and adjusting individual airway pressures and tidal volumes. ./cache/cord-267942-ykl2xy7y.txt ./txt/cord-267942-ykl2xy7y.txt