id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314872-njlgggzq	Kornilov, Sergey A.	Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19	2020-07-22		.txt	text/plain	1365	74	48	We interrogated the associations between plasma concentrations of sACE2 and biomarkers of metabolic syndrome (body mass index, BMI; blood pressure; glycemic markers; and lipid levels), adiposity (plasma leptin and serum adiponectin), inflammation (high-sensitivity Creactive protein, hsCRP, white blood cell count, and interleukin-8), and liver damage (alanine aminotransferase, aspartate transaminase, and gamma-glutamyltransferase, GGT) in a large cohort of participants in a commercial wellness program who had undergone comprehensive multi-omic profiling (N = 2051; 1238 women and 813 men, aged 22 to 87 years, M = 47.3, SD = 11.71) (see [5] for details). BMI, body mass index; MAP, mean arterial blood pressure; HbA1c, glycohemoglobin A1c; HOMA-IR, homeostatic model assessment of insulin resistance; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; IL-8, interleukin 8; hsCRP, high-sensitivity C-reactive protein; ALAT, alanine aminotransferase; ASAT, aspartate transaminase; GGT, gamma-glutamyl-transferase Individuals who met World Health Organization's diagnostic criteria for metabolic syndrome (MetS) (N = 171) displayed elevated plasma sACE2 levels compared to controls (N = 1880; P = 4.7 × 10 − 5 ); the effect was stronger in men (P int = 8.9 × 10 − 5 ).	./cache/cord-314872-njlgggzq.txt	./txt/cord-314872-njlgggzq.txt