id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353344-tzyu6j6n	van Berkel, Miranda	Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?	2020-10-06		.txt	text/plain	1082	78	53	PCT appears to increase in COVID patients with severe disease and/or in those presenting with secondary bacterial infections [6] . The use of biomarkers to predict secondary infections in ICU patients warrants reappraisal in times of COVID-19. We demonstrate that COVID-19 patients who do not develop a bacterial infection present with high initial CRP levels and lowmoderate PCT levels that gradually decrease over time. Furthermore, our data show that, during ICU admission, PCT levels of > 1.00 μg/L rule in, whereas concentrations of < 0.25 μg/L rule out secondary bacterial infections with good predictive values. As CRP is consistently elevated, this biomarker does not have predictive value for bacterial infections in the initial phase of COVID-19. b Serial values of PCT (left panel) and CRP (right panel) in patients (n = 33) with COVID-19 who did develop (n = 33) or did not (n = 33) develop a secondary infection.	./cache/cord-353344-tzyu6j6n.txt	./txt/cord-353344-tzyu6j6n.txt