id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305966-a61v2615	Pourani, Mohammad Reza	CD147 inhibitors as a treatment for melanoma: promising agents against SARS‐CoV‐2 infection	2020-10-24		.txt	text/plain	529	52	53	1 The CD147 protein (known as basigin) is a transmembrane protein that has recently been suggested as a potential receptor for SARS-CoV-2. 2 Recent studies have reported that the spike protein of SARS-CoV-2 attaches to host cells via angiotensin-converting enzyme-2 (ACE-2) and CD147 receptors. 3 In fact, recent studies have suggested CD147 as a novel tumor marker in the early diagnosis of some cancers like head and neck squamous cell carcinoma and hepatocellular carcinoma. 8 In conclusion, considering the possible role of CD147 in the pathogenesis of COVID-19, CD147 inhibitors may be considered as promising treatments for SARS-CoV-2 infection. CD147 as a target for COVID-19 treatment: suggested effects of azithromycin and stem cell engagement CD147-targeted siRNA in A375 malignant melanoma cells induces the phosphorylation of EGFR and downregulates cdc25C and MEK phosphorylation Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression FDA approved drugs with pharmacotherapeutic potential for SARS CoV-2 (COVID-19) therapy	./cache/cord-305966-a61v2615.txt	./txt/cord-305966-a61v2615.txt