id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005057-deq5tv1d	Bergström, T.	Neurovirulence of herpes simplex virus types 1 and 2 isolates in diseases of the central nervous system	1990		.txt	text/plain	3487	163	48	Herpes simplex virus (HSV) isolates derived from the central nervous system of ten patients with HSV-1-induced encephalitis, one patient with multiple sclerosis, and 14 patients with HSV-2-induced meningitis were investigated for neurovirulence by assaying the LD(50) after nose and intracerebral (i.c.) inoculation of mice. Vahlne t Herpes simplex virus (HSV) isolates derived from the central nervous system of ten patients with HSV-l-induced encephalitis, one patient with multiple sclerosis, and 14 patients with HSV-2-induced meningitis were investigated for neurovirnlence by assaying the LDs0 after nose and intracerebrai (i.c.) inoculation of mice. No correlation between high neurovirulence (defined as low LDs0 for both routes of infection) and replication in cell cultures of neuronal and non-neuronal cell lines was found, but the weakly neuruvirulent HSV-1 strain isolated from a patient with multiple sclerosis gave low replication yields.	./cache/cord-005057-deq5tv1d.txt	./txt/cord-005057-deq5tv1d.txt