id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006302-pnnkfid0	Ioakeimidou, A.	Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction	2017-04-28		.txt	text/plain	2944	160	51	We studied the follow-up changes of circulating vasoactive peptides and cytokines until the improvement or the worsening of a patient and progression into specific organ dysfunctions. In a prospective study, concentrations of tumor necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8, IL-10, interferon-gamma (IFNγ), endocan and angiopoietin-2 (Ang-2) were measured in serum by an enzyme immunoassay in 175 patients at baseline; this was repeated within 24 h upon progression into new organ dysfunction (n = 141) or improvement (n = 34). Our aims were to monitor the changes of circulating levels of pro-inflammatory and antiinflammatory cytokines and of vasoactive peptides of critically ill patients at well-defined time-points of the clinical course and to understand how these changes mediate progression to organ dysfunction in an individualized way. When pair-wise comparisons between baseline and follow-up measurements were done within the subgroups of patients developing new organ dysfunctions, it was found that the only parameters significantly changing were endocan and Ang-2.	./cache/cord-006302-pnnkfid0.txt	./txt/cord-006302-pnnkfid0.txt