id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010959-sigw7yxk	Lampejo, Temi	Influenza and antiviral resistance: an overview	2020-02-13		.txt	text/plain	4490	211	40	Resistance to neuraminidase inhibitors has remained at low levels to date and the majority of resistance is seen in influenza A H1N1 pdm09 infected immunocompromised individuals receiving oseltamivir but is also seen less frequently with influenza A H3N2 and B. This potential for vast genetic variability within influenza viruses and their highly error-prone RNA dependent RNA polymerase does raise concerns regarding the possible emergence of treatment resistant strains and generates further questions regarding their viral fitness and transmissibility as well as which strategies to employ in rapidly identifying and effectively treating these resistance variants. Neuraminidase inhibitor susceptibility testing should be considered particularly in young children and immunocompromised patients being treated with a neuraminidase inhibitor for influenza (especially H1N1 pdm09), who are not responding to treatment and/or have persistently high viral loads (low cycle threshold values using RT-PCR) and/or exposed to a suspected or confirmed resistant case.	./cache/cord-010959-sigw7yxk.txt	./txt/cord-010959-sigw7yxk.txt