id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275561-9f1las3y	Wielders, C. C. H.	Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms	2015-01-11		.txt	text/plain	3895	192	46	title: Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms Single nucleotide polymorphisms (SNPs) in the IFNG (rs2430561/rs1861493), STAT1 (rs1914408), and VDR (rs2228570) genes were determined in 85 patients from the 2007 Dutch acute Q fever outbreak, and a symptom score was calculated. burnetii antigens ≥1:64 (indirect immunofluorescence assay, IFA; Focus Diagnostics, Cypress, CA, USA)], based on available questionnaire data (self-reported symptoms), including no more than one person per household, and giving consent for the investigation of genetic differences. This study investigated the association of four SNPs in several immune response genes with susceptibility to and severity of self-reported symptoms in acute C. In conclusion, a significant difference was found for the IFNG rs1861493 SNP between persons with a mild or more severe presentation of acute Q fever, which was not confirmed in a second study population.	./cache/cord-275561-9f1las3y.txt	./txt/cord-275561-9f1las3y.txt