id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-338070-y8zi8iz9	Liu, Wei	Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice	2020-08-31		.txt	text/plain	4108	234	50	This study aimed to explore the effects of PARP-1 inhibitor olaparib on IAV-induced lung injury and the underlying mechanisms. To the expectations, mice in the olaparib group showed higher survival rate compared with that in the IAV group in a dose-dependent manner, indicating that olaparib could powerfully protect against influenza virus challenge in by H&E staining and the quantitative analysis of histological changes in the lung tissues (e) (n = 8 for each group). The detection of cytokine/chemokine in BALF samples at day 6 post-infection showed that IL-6, MCP-1, G-CSF, TNF-α, CXCL1, CXCL10, CCL3, and RANTES were remarkably increased in the IAV group compared with those in the control group, while olaparib treatment significantly reduced the abnormal increased levels of the above cytokine/chemokines, which was similar with the results obtained from lung tissue (Fig. 4a-h) . To explore the mechanisms underlying the protective effect of olaparib against IAV-induced injury to murine lungs, western blot was performed to detect the PARPs, the marker of apoptosis.	./cache/cord-338070-y8zi8iz9.txt	./txt/cord-338070-y8zi8iz9.txt