id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-339934-g6ufz29l	Yu, Hai-qiong	Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients	2020-05-13		.txt	text/plain	993	55	45	In the case of respiratory infection, while IgM and IgG isotypes have been the primary emphasis in characterizing immunity, mucosal and systemic IgA responses that may play a critical role in the disease pathogenesis, have received much less attention. This pattern of humoral immune response is different in case of SARS-CoV infection, in which IgM and IgA showed similar chronological profiles in terms of both seroconversion time and antibody titres [5] , in line with the knowledge that viremia is common in SARS. Upregulated IgA production may be the result of increased levels of TGF-β and IL-10 that promote antibody switching in SARS-CoV-2 infection. Considering the roles of mucosal and systemic IgA in COVID-19, inducing IgA production, e.g. using Lactoferrin to activate canonical TGF-β signaling [13] , or retinoic acid to enhance lactoferrin-induced IgA responses [14] , has been proposed as novel therapies for severe COVID-19.	./cache/cord-339934-g6ufz29l.txt	./txt/cord-339934-g6ufz29l.txt