id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000647-uofygmeu	Stäger, Simona	CD8(+) T Cells in Leishmania Infections: Friends or Foes?	2012-01-24		.txt	text/plain	6676	307	46	However, since CTLs have been www.frontiersin.org observed in various mouse models and also in human patients, a possible protective role for Leishmania-specific cytotoxic T cells should not be excluded. major infection became less important also because of the strong evidence that Th1 cells were the primary cells involved in mediating protection against cutaneous leishmaniasis (Reiner and Locksley, 1995; Louis et al., 1998; Sacks and Noben-Trauth, 2002) . Vaccination of humans with heat-killed Leishmania or recombinant parasite proteins has so far failed to induce long-term immunity and only recovery from natural or experimental infection has provided proper protection. Pilot studies in the murine model of VL have also demonstrated that adoptive transfer of antigen-specific CD8 + T cells (Polley et al., 2006) or reactivation of CD8 + T cell responses through a therapeutic vaccine (Joshi et al., 2009) results in the control of parasite growth.	./cache/cord-000647-uofygmeu.txt	./txt/cord-000647-uofygmeu.txt