id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001674-tp4o7fxx	Oliveira, Cláudia C.	Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome	2015-06-05		.txt	text/plain	6630	347	46	An exception is the C-terminal peptide of the endoplasmic reticulum (ER)-membrane-spanning ceramide synthase Trh4 that is surprisingly liberated by the signal peptide peptidase (SPP), the proteolytic enzyme involved in cleaving leader sequences. This intramembrane proteolysis by SPP is thought to be important for the clearance of the ER membrane by removing small protein remnants anchored at FIGURE 1 | Classical and alternative pathways for MHC class I presentation. Furin-processed antigens targeted to the secretory route were presented by MHC class I at the cell surface and could elicit functional CD8 T-cell responses in vivo in a TAP-independent fashion (75, 81) . Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway A transporter associated with antigen-processing independent vacuolar pathway for the MHC class I-mediated presentation of endogenous transmembrane proteins	./cache/cord-001674-tp4o7fxx.txt	./txt/cord-001674-tp4o7fxx.txt