id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003091-uvfppirt	Gornati, Laura	Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines	2018-06-27		.txt	text/plain	9424	460	40	Taking advantage of new adjuvants, innovative ags-delivery carriers and targeting strategies, it is now feasible to optimize the activation and ag presentation processes by the specific DCs subset that is the most effective in the initiation of the adaptive response needed in a given context. Indeed, MF59, an oil-in-water emulsion adjuvant, that allows long-lasting ag retention in draining LN and enhanced ag uptake by LN-resident DCs, promotes robust humoral responses via follicular DC activation (43) and CD4 + T cell immunity induction (44) . In addition to the use of NPs, targeting DC-specific receptors has become an attractive strategy for vaccine development due to the enforced efficiency of immune responses when compared to generic-delivering approaches. Moreover, vaccines based on the filamentous bacteriophage fd presenting an αDEC-205 scFv, efficiently induce DCs maturation via the activation of the TLR9-MyD88 pathway (144) , without adjuvants and further elicit potent antitumor responses when compared to non-tailored ag delivery (145) .	./cache/cord-003091-uvfppirt.txt	./txt/cord-003091-uvfppirt.txt