id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003724-705h5l06	Di Lullo, Giulia	Identification of a Novel Non-desmoglein Autoantigen in Pemphigus Vulgaris	2019-06-19		.txt	text/plain	4132	191	38	Pemphigus vulgaris (PV) is an autoimmune bullous disease of the skin and mucous membranes characterized by the presence of circulating and tissue-bound autoantibodies against keratinocyte cell surface antigens, specifically desmoglein (Dsg) 1 and 3. The existence of both pathogenic and non-pathogenic anti-Dsg autoAbs has recently been underscored by isolation of human monoclonal antibodies (hMabs) from pemphigus patients. Then, considering that previous studies demonstrated the ability of intact autoAbs to enter living cells (8, 16, 17) , we addressed the potential pathogenicity of α-catenin-specific Mab PVF144 by evaluating its acantholytic activity in an in vitro keratinocyte dissociation assay. Further studies are needed: (i) to evaluate whether PVF144 may act synergistically with anti-Dsg antibodies using more informative approaches, such as in vitro organ culture or in vivo models; (ii) to assess the possible role of anti-α-catenin autoAbs in pemphigus initiation and evolution in vivo; and (iii) to characterize this novel antigen as a possible target of epitope spreading phenomena in PV.	./cache/cord-003724-705h5l06.txt	./txt/cord-003724-705h5l06.txt