id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-030803-6i0e2zkd	Hu, Wan-Chung	A Framework of All Discovered Immunological Pathways and Their Roles for Four Specific Types of Pathogens and Hypersensitivities	2020-08-07		.txt	text/plain	3125	216	49	STAT5a and STAT5b have distinct target genes in immune responses (15) , and STAT5b is the transcription factor that induces Tfh. Tfh can induce B-cells to produce IgM antibodies and IL-21 produced by Tfh facilitates B cell isotype switching to IgG (16, 17) . Type 2 myeloid dendritic cells (CD141+ mDC2) are the antigen presenting cells Eradicable immune responses include TH1, TH2, TH17, and THαβ. Initiation of eradicable immunity also requires innate lymphoid cells to produce the initial cytokines that drive different immunological pathways. THαβ immune responses against self-antigens present as type 2 antibody-dependent cytotoxic hypersensitivity, such as the acute stage of myasthenia gravis or Graves' disease (37) . The effector cells of TH1-like immune responses include suppressive macrophages (M2), ILC1, suppressive CD8 T cells (CD28-CD8+Treg), IgA1producing B-cells, iNKT1 cells, and IFN-γ-/TGF-β-producing CD4 T cells (24, 40, 56) . TH3 immune responses induce type 2 antibody-dependent cytotoxic hypersensitivity, including the chronic stage of Systemic Lupus Erythematosus (SLE) (69) .	./cache/cord-030803-6i0e2zkd.txt	./txt/cord-030803-6i0e2zkd.txt