id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253108-p3wlw5d4	Olson, Brian M.	Interleukin 35: A Key Mediator of Suppression and the Propagation of Infectious Tolerance	2013-10-18		.txt	text/plain	7447	260	36	Following more than a decade of studies aimed at elucidating the mechanisms that mediate Treg activity, interest was rekindled in the mid-1990s with the transformational research of Sakaguchi and colleagues, who specifically identified a population of CD4+CD25+ T cells that had suppressive function, which were coined as naturally occurring thymic-derived Tregs, or natural Abbreviations: APC, antigen-presenting cell; DC, dendritic cell; EAE, experimental autoimmune encephalitis; Ebi3, Epstein-Barr virus-induced gene 3; IL, interleukin; iTreg, induced regulatory T cell; NIMA, non-inherited maternal antigen; NK, natural killer; nTreg, natural regulatory T cell; PAP, prostatic acid phosphatase; TGF, transforming growth factor; Treg, regulatory T cell. When activated in these conditions, iTregs gain potent suppressive functions, inhibiting T-cell proliferation and effector functions in an antigen non-specific fashion, and play a central role in mediating regulation and propagating infectious tolerance in a variety of malignancies, including infectious diseases and cancer.	./cache/cord-253108-p3wlw5d4.txt	./txt/cord-253108-p3wlw5d4.txt