id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265855-zf52vl11	Mayor-Ibarguren, Ander	A Hypothesis for the Possible Role of Zinc in the Immunological Pathways Related to COVID-19 Infection	2020-07-10		.txt	text/plain	5324	283	47	Zinc deficiency may increase ACE-2 receptor activity on type 2 pneumocytes and other cells that are infected by SARS-COV-2, mainly in the lower respiratory tract. Although there are no specific data regarding zinc in this pathway for SARS-CoV-2, zinc may limit infection through upregulation of IFN-alpha production and an increase in its antiviral activity (77, 78) . Thus, patients with IL-6-174 GG polymorphism (C-carriers) may be susceptible to developing a severe infection due to SARS-CoV-2, leading to an increase in IL-6 levels that produce a cytokine storm related to impaired zinc homeostasis. We believe there is enough evidence to further investigate how zinc status or homeostasis is involved in the pathogenesis of severe illness produced by SARS-CoV-2 infection, and its potential role as an active treatment should be assessed in clinical trials.	./cache/cord-265855-zf52vl11.txt	./txt/cord-265855-zf52vl11.txt