id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268781-6l74rrlm	Poh, Chek Meng	Multiplex Screening Assay for Identifying Cytotoxic CD8(+) T Cell Epitopes	2020-03-11		.txt	text/plain	6116	312	50	Besides, our results from human PBMCs and three independent infectious animal models (MERS, influenza and malaria) further reveal that IFNγ expression by epitope-specific CD8 + T cells does not always correlate with their cell-killing potential, highlighting the need for using cytotoxicity assays in specific contexts (e.g., evaluating vaccine candidates). Besides, our results from human PBMCs and three independent infectious animal models (MERS, influenza and malaria) further reveal that IFNγ expression by epitope-specific CD8 + T cells does not always correlate with their cell-killing potential, highlighting the need for using cytotoxicity assays in specific contexts (e.g., evaluating vaccine candidates). Splenocytes from vaccinated mice challenged by a lethal PR8 infection were used to measure epitope-specific CD8 T cell effector functions through direct (in vivo cytotoxicity) and indirect (IFNγ-ICS) assays.	./cache/cord-268781-6l74rrlm.txt	./txt/cord-268781-6l74rrlm.txt