id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-283505-ousbar6c	Horman, William S. J.	The Dynamics of the Ferret Immune Response During H7N9 Influenza Virus Infection	2020-09-24		.txt	text/plain	5896	266	45	To elucidate the cellular immune mechanisms associated with disease severity and progression, we used a ferret model to closely resemble disease outcomes in humans following influenza virus infection. In this study, we aimed to examine the ferret immune response to H7N9 influenza virus infection by analyzing leukocyte population variation associated with disease pathogenesis. While the day 6 ferret which showed worsened disease progression did exhibit the most severe lung pathology, the lack of viral antigen in and around these lesions (Supplementary Figure 1) means they cannot conclusively be classified as being caused by the influenza infection, and thus we are hesitant to classify disease presentation in this ferret as like a high pathogenicity infection based on the histopathology findings regardless of the increase in clinical signs. Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses	./cache/cord-283505-ousbar6c.txt	./txt/cord-283505-ousbar6c.txt