id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291941-9a4tt4f7	Barber-Axthelm, Isaac M.	Understanding the Role of Mucosal-Associated Invariant T-Cells in Non-human Primate Models of HIV Infection	2020-08-18		.txt	text/plain	5258	252	43	Herein, we discuss the current state of MAIT cell characterization in NHPs [which has focused on rhesus macaques (RM), pigtail macaques (PTM), and Mauritian cynomolgus macaques (MCM)] and the changes in MAIT cell populations that occur during simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infection, which are the critical animal models for HIV infection. MAIT cells are consistently maintained at low frequencies in secondary lymphoid organs (lymph nodes and spleen) compared to the peripheral blood, in both humans and NHPs. This is attributed to the relative lack of CCR7 and CD62L expression, both required for lymphoid tissue homing, on peripheral MAIT cells [reviewed in Kurioka et al. The lack of MAIT cell depletion during acute infection is consistent with what has been observed in humans during initial HIV infection and emphasizes the importance of the NHP-SIV/SHIV model to study MAIT cell dynamics during peracute infection.	./cache/cord-291941-9a4tt4f7.txt	./txt/cord-291941-9a4tt4f7.txt