id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304626-ffao7vka	Mellors, Jack	Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics	2020-07-09		.txt	text/plain	11744	539	34	A better understanding of this virus-host interplay and its contribution to pathogenesis has previously led to: the identification of genetic factors which influence viral infection and disease outcome, the development of novel antivirals, and the production of safer, more effective vaccines. Infected host cells which present viral antigens on the cell surface membrane can activate the classical pathway, as the antigens bind IgM/IgG to induce complement dependent cytotoxicity (CDC). Non-neutralizing antibodies can still bind the viral target with the potential to cross-link with Fc receptors, or activate complement and interact with complement receptors, to enhance viral infection of host cells (241) . Use of the non-neutralizing influenza virus M2 extracellular vaccine in mice required functional C3 to confer protection and induce effective humoral and cell-mediated immune responses (245) .	./cache/cord-304626-ffao7vka.txt	./txt/cord-304626-ffao7vka.txt