id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-313431-swkcdvx8	Becerra-Diaz, Mireya	Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung	2020-08-07		.txt	text/plain	14972	789	40	The opposite effects seen in different inflammatory contexts highlight the need for a deeper and broader study of the androgen/ARmediated modulation of monocytes and macrophages, as these cells participate in both the initial and late phases of immune responses in a variety of diseases. Studies of androgen receptor function in human monocytes and macrophages have focused primarily on the roles of male sex and sex hormones in promoting atherosclerotic foam cell formation (196) and inhibiting cutaneous wound healing (186, 215) . There is a paucity of literature regarding how introducing or depleting exogenous sex hormones (such as in female-to-male transgender individuals receiving testosterone supplementation or women with estrogen blockade) affects the function of blood monocytes and lung macrophages in men and women with asthma. Modulation of monocyte and macrophage function mediated by the interaction of androgen and AR has been examined mostly by correlative studies in humans following lifespan changes in sex hormones or using hormonal manipulation in mouse models of lung disease.	./cache/cord-313431-swkcdvx8.txt	./txt/cord-313431-swkcdvx8.txt