id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318630-h6j7iqbm	Sinha, Sushmita	CD8(+) T-Cells as Immune Regulators of Multiple Sclerosis	2015-12-10		.txt	text/plain	9004	465	50	In our studies, we have shown that cytotoxic/suppressor CD8(+) T-cells are CNS antigen-specific, MHC class I-restricted, IFNγand perforin-dependent, and are able to inhibit disease. iNTRODUCTiON Studies addressing the immunobiology of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) have focused on CD4 + T-cells as the main orchestrators of pathogenesis and regulation. Interestingly, immune deviation can be elicited against myelin antigens (61, 62) , pointing to the potential role for Qa-1-restricted CD8 + T-cells in EAE disease. We have also demonstrated that GA treatment induces CD8 + Treg in mice, and that these CD8 + T-cells are required for GA to be therapeutically effective in ameliorating EAE disease (64) . Furthermore, relapses in MS are associated with significantly lower CNS-specific CD8 + T-cell suppressor ability, while this potential in MS patients during quiescence is similar to healthy donors, suggesting a role with disease activity (5) .	./cache/cord-318630-h6j7iqbm.txt	./txt/cord-318630-h6j7iqbm.txt