id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319774-mkz7z38o	Hou, Dongni	High-Throughput Sequencing-Based Immune Repertoire Study during Infectious Disease	2016-08-31		.txt	text/plain	6126	310	36	The selectivity of the adaptive immune response is based on the enormous diversity of T and B cell antigen-specific receptors. During the past two decades, however, technical advances in high-throughput sequencing (HTS), also known as next-generation sequencing (NGS), along with evolving bioinformatic and statistical tools, have provided a new approach capable of analyzing the immune repertoire at the single sequence level. The depth and comprehensiveness of high-throughput immune repertoire sequencing are greater than ever, and the enormous sequencing data of disease-specific TCR/BCR clones provide great potential for the revealing dynamic changes in clonality during infectious states. Decrease in the overall diversity of the immune repertoire have been observed after various antigen exposures, including HIV, influenza, and human herpes virus, which implies expansion of particular T/B cell clones (67, 88, 92, 93) . Pairing the heavy and light chains as an integrated antibody has been another challenge for HTS-based immune repertoire analysis.	./cache/cord-319774-mkz7z38o.txt	./txt/cord-319774-mkz7z38o.txt